Adrenal Gland Hyperfunction malady

NINDS: Cushing's syndrome, also called , is a rare endocrine disorder caused by chronic exposure of the body's tissues to excess levels of cortisol - a hormone naturally produced by the adrenal gland. Exposure to too much cortisol can occur from long-term use of synthetic glucocorticoid hormones to treat inflammatory illnesses. Pituitary adenomas (benign tumors of the pituitary gland) that secrete increased amounts of ACTH ( a substance that controls the release of cortisol) can also spur overproduction of cortisol. Tumors of the adrenal gland and ectopic ACTH syndrome (a condition in which ACTH is produced by various types of potentially malignant tumors that occur in different parts of the body) can cause similar problems with cortisol balance. Common symptoms of Cushing's syndrome include upper body obesity, severe fatigue and muscle weakness, high blood pressure, backache, elevated blood sugar, easy bruising, and bluish-red stretch marks on the skin. In women, there may be increased growth of facial and body hair, and menstrual periods may become irregular or stop completely. Neurological symptoms include difficulties with memory and neuromuscular disorders.³¹

MalaCards: Adrenal Gland Hyperfunction, also known as hypercortisolism, is related to cushing's syndrome and petrositis. An important gene associated with Adrenal Gland Hyperfunction is HSD3B1 (hydroxy-delta-5-steroid dehydrogenase, 3 beta- and steroid delta-isomerase 1), and among its related pathways are Selected targets of CREB1 and Steroid hormone biosynthesis. The drugs fludrocortisone and fludrocortisone acetate and the compounds glucose and creatinine have been mentioned in the context of this disorder. Affiliated tissues include cortex, adrenal gland and skin.

Genetics Home Reference: Cushing disease is caused by elevated levels of a hormone called cortisol, which leads to a wide variety of signs and symptoms. This condition usually occurs in adults between the ages of 20 and 50; however, children may also be affected. The first sign of this condition is usually weight gain around the trunk and in the face. Affected individuals may get stretch marks (striae) on their thighs and abdomen and bruise easily. Individuals with Cushing disease can develop a hump on their upper back caused by abnormal deposits of fat. People with this condition can have muscle weakness, severe tiredness, and progressively thin and brittle bones that are prone to fracture (osteoporosis). They also have a weakened immune system and are at an increased risk of infections. Cushing disease can cause mood disorders such as anxiety, irritability, and depression. This condition can also affect a person's concentration and memory. People with Cushing disease have an increased chance of developing high blood pressure (hypertension) and diabetes. Women with Cushing disease may experience irregular menstruation and have excessive hair growth (hirsutism) on their face, abdomen, and legs. Men with Cushing disease may have erectile dysfunction. Children with Cushing disease typically experience slow growth.¹⁷

Wikipedia: Adrenocortical hyperfunction is a condition where there is an overexpression of products of the adrenal...⁴⁴ more...

Aliases & Descriptions:

adrenal gland hyperfunction 6 30 8 43 hypercortisolism 6 31 32 hyperadrenalism 6 30 disorder of corticoadrenal overactivity 6

adrenocortical hyperfunction 6 hypercortisolism (disorder) 6 overproduction of cortisol 6

Diseases related to adrenal gland hyperfunction by text searches and GeneDecks gene sharing:

(show top 50)    (show all 109)

id	Related Disease	Score	Top Affiliating Genes
1	cushing's syndrome	30.4	PRL, HSD11B2, INS
2	petrositis	27.6	PRL, AVP
3	sinusitis	26.3	PRL, INS, AVP
4	adrenal hyperplasia	26.2	PRL, HSD3B1, HSD11B2, INS, AVP
5	pseudohermaphroditism	12.9	HSD3B1, PRL
6	neurogenic diabetes insipidus	12.9	AVP, PRL
7	panhypopituitarism	12.9	AVP, PRL
8	familial prostate cancer	12.9	PRL, HSD3B1
9	germinoma	12.9	AVP, PRL
10	leydig cell tumor	12.8	PRL, HSD3B1
11	alcohol abuse	12.8	AVP, PRL
12	glucocorticoid resistance	12.7	HSD11B2, PRL
13	sexual disorder	12.6	PRL, INS
14	empty sella syndrome	12.6	INS, PRL
15	sheehan syndrome	12.6	PRL, INS
16	endogenous depression	12.6	PRL, INS
17	pituitary gland disease	12.6	INS, PRL
18	hypothalamic hamartomas	12.6	INS, PRL
19	granulosa cell tumor of the ovary	12.6	INS, PRL
20	combined pituitary hormone deficiency	12.6	INS, PRL
21	androgenetic alopecia	12.6	PRL, INS
22	pituitary hormone deficiency	12.6	PRL, INS
23	fragile x-associated primary ovarian insufficiency	12.6	PRL, INS
24	anovulation	12.6	PRL, INS
25	acanthosis nigricans	12.6	PRL, INS
26	neuroectodermal endocrine syndrome	12.6	PRL, INS
27	polycystic ovary syndrome	12.6	PRL, INS
28	cystinosis	12.6	PRL, INS
29	cluster headache	12.6	PRL, INS
30	gastroparesis	12.6	INS, PRL
31	hemorrhagic fever with renal syndrome	12.6	PRL, INS
32	21-hydroxylase deficiency	12.6	PRL, INS
33	back pain	12.6	INS, PRL
34	anophthalmia	12.5	PRL, INS
35	hyperprolactinemia	12.5	PRL, INS
36	pituitary tumor	12.5	PRL, HSD11B2
37	head injury	12.5	PRL, INS
38	sleep disorder	12.5	PRL, INS
39	bulimia nervosa	12.5	INS, PRL
40	systemic scleroderma	12.5	INS, PRL
41	hypogonadotropism	12.5	PRL, INS
42	rheumatoid arthritis, association with	12.5	INS, PRL
43	adrenocortical carcinoma	12.5	HSD3B1, PRL
44	amenorrhea	12.5	INS, PRL
45	hyperaldosteronism	12.5	HSD11B2, INS
46	klinefelter's syndrome	12.5	PRL, INS
47	end stage renal failure	12.5	INS, PRL
48	schizoaffective disorder	12.4	PRL, INS
49	fibromyalgia	12.4	PRL, INS
50	prolactinoma	12.4	INS, PRL

Approved drugs:

Drug clinical trials:

Inferred drug relations via UMLS/NDF-RT:

^43 28 fludrocortisone, fludrocortisone acetate

MalaCards organs/tissues related to adrenal gland hyperfunction:

²²

Genes related to adrenal gland hyperfunction according to GeneCards:

id	Symbol	Description	Score	GeneCards Section Context
1	HSD3B1	hydroxy-delta-5-steroid dehydrogenase, 3 beta- and steroid delta-isomerase 1	11.0
2	AVP	arginine vasopressin	11.0
3	HSD11B2	hydroxysteroid (11-beta) dehydrogenase 2	11.0
4	INS	insulin	11.0
5	PRL	prolactin	11.0

Pathways related to adrenal gland hyperfunction according to GeneDecks:

id	Pathway	Score	Top Affiliating Genes
1	Selected targets of CREB110	9.1	AVP, INS
2	Steroid hormone biosynthesis20	9.1	HSD11B2, HSD3B1
3	Aldosterone-regulated sodium reabsorption20	8.9	INS, HSD11B2

Compounds related to adrenal gland hyperfunction according to GeneDecks:

(show all 24)

id	Compound	Score	Top Affiliating Genes
1	glucose32	10.2	AVP
2	creatinine32	10.0	HSD11B2
3	17-hydroxyprogesterone32 18	10.7	PRL, HSD3B1
4	3beta-hydroxysteroid32	9.6	HSD11B2, HSD3B1
5	clomiphene citrate32	9.4	INS, PRL
6	cyproteroneacetate32	9.4	INS, PRL
7	melatonin32 42 9 18 9	13.3	AVP, PRL
8	cortisone32 18	10.3	INS, HSD11B2
9	dehydroepiandrosterone sulfate32	9.3	PRL, INS
10	olanzapine32 34 9 18 9	13.3	INS, PRL
11	octreotide32 42 9 9	12.2	INS, PRL
12	nadh32 9 18 9	12.1	AVP, HSD11B2, HSD3B1
13	progesterone32 42 9 18 9	12.9	PRL, HSD3B1, HSD11B2
14	dhea32	8.9	INS, HSD11B2, PRL
15	hydrocortisone32 9 9	10.8	PRL, HSD11B2, INS
16	uric acid32 18	9.8	AVP, INS
17	steroid32	8.7	AVP, HSD11B2, HSD3B1, PRL
18	testosterone32 9 18 9	11.7	INS, HSD3B1, PRL
19	androstenedione32 18	9.4	INS, HSD11B2, HSD3B1, PRL
20	estrogen32	8.3	PRL, HSD3B1, HSD11B2, INS
21	acth32	8.3	PRL, HSD11B2, INS, AVP
22	norepinephrine32 9 18 9	11.3	PRL, HSD11B2, INS, AVP
23	dexamethasone32 42 34 9 9	12.3	PRL, HSD11B2, INS, AVP
24	arginine32	8.3	PRL, HSD11B2, INS, AVP

Cellular components related to adrenal gland hyperfunction according to GeneDecks:

id	Name	GO ID	Score	Top Affiliating Genes
1	secretory granule	GO:030141	9.1	AVP, INS

Biological processes related to adrenal gland hyperfunction according to GeneDecks:

id	Name	GO ID	Score	Top Affiliating Genes
1	female pregnancy	GO:007565	9.3	HSD11B2, PRL
2	glucocorticoid biosynthetic process	GO:006704	9.3	HSD11B2, HSD3B1
3	positive regulation of cell growth	GO:030307	8.8	AVP, INS

Molecular functions related to adrenal gland hyperfunction according to GeneDecks:

id	Name	GO ID	Score	Top Affiliating Genes
1	hormone activity	GO:005179	9.1	INS, PRL