MCID: ADR013
MIFTS: 24

Adrenal Gland Hyperfunction malady

Rare diseases, Endocrine diseases categories

Aliases & Classifications for Adrenal Gland Hyperfunction

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Adrenal Gland Hyperfunction, Aliases & Descriptions:

Name: Adrenal Gland Hyperfunction 9 41 60
Hypercortisolism 9 42 43
Hyperadrenalism 9 41
Disorder of Corticoadrenal Overactivity 9
 
Pituitary-Dependent Cushing's Disease 60
Adrenocortical Hyperfunction 9
Overproduction of Cortisol 9
Cushing Syndrome 60


Classifications:

Malacards categories (disease lists): (See all malacards categories)
Global: Rare diseases
Anatomical: Endocrine diseases


External Ids:

Disease Ontology9 DOID:3947
MeSH33 D000308

Summaries for Adrenal Gland Hyperfunction

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NINDS:42 Cushing's syndrome, also called , is a rare endocrine disorder caused by chronic exposure of the body's tissues to excess levels of cortisol - a hormone naturally produced by the adrenal gland. Exposure to too much cortisol can occur from long-term use of synthetic glucocorticoid hormones to treat inflammatory illnesses. Pituitary adenomas (benign tumors of the pituitary gland) that secrete increased amounts of ACTH ( a substance that controls the release of cortisol) can also spur overproduction of cortisol. Tumors of the adrenal gland and ectopic ACTH syndrome (a condition in which ACTH is produced by various types of potentially malignant tumors that occur in different parts of the body) can cause similar problems with cortisol balance. Common symptoms of Cushing's syndrome include upper body obesity, severe fatigue and muscle weakness, high blood pressure, backache, elevated blood sugar, easy bruising, and bluish-red stretch marks on the skin. In women, there may be increased growth of facial and body hair, and menstrual periods may become irregular or stop completely. Neurological symptoms include difficulties with memory and neuromuscular disorders.

MalaCards based summary: Adrenal Gland Hyperfunction, also known as hypercortisolism, is related to cushing's syndrome and hyperaldosteronism. The drugs aminoglutethimide and mitotane have been mentioned in the context of this disorder. Affiliated tissues include adrenal gland, pituitary and cortex.

Wikipedia:63 Adrenocortical hyperfunction is a condition where there is an overexpression of products of the adrenal... more...

Related Diseases for Adrenal Gland Hyperfunction

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Diseases related to Adrenal Gland Hyperfunction via text searches within MalaCards or GeneCards Suite gene sharing:

(show all 47)
idRelated DiseaseScoreTop Affiliating Genes
1cushing's syndrome10.4
2hyperaldosteronism10.3
3adenoma10.2
4multiple endocrine neoplasia iia10.1
5multiple endocrine neoplasia 110.1
6mccune-albright syndrome, somatic, mosaic10.1
7liver disease10.1
8fatty liver disease10.1
9congenital adrenal hyperplasia10.1
10hyperandrogenism10.1
11adrenal adenoma10.1
12pituitary adenoma10.1
13central serous chorioretinopathy10.1
14cortisone reductase deficiency10.1
15rheumatoid arthritis9.9
16hyperprolactinemia9.9
17pigmented nodular adrenocortical disease, primary, 39.9
18polycythemia vera9.9
19smith-lemli-opitz syndrome9.9
20acth-independent macronodular adrenal hyperplasia9.9
21pheochromocytoma9.9
22obesity9.9
23androgen insensitivity, partial, with or without breast cancer9.9
24arthritis9.9
25hepatitis9.9
26sinusitis9.9
27petrositis9.9
28steatorrhea9.9
29nelson syndrome9.9
30hyperphosphatemia9.9
31primary pigmented nodular adrenocortical disease9.9
32metabolic syndrome x9.9
33conn's syndrome9.9
34diarrhea9.9
35functioning pituitary adenoma9.9
36hypothyroidism9.9
37peptic ulcer disease9.9
38pituitary carcinoma9.9
39polycythemia9.9
40thymoma9.9
41bird-headed dwarfism with progressive ataxia, insulin-resistant diabetes, goiter and primary gonadal insufficiency9.9
42carney triad9.9
43lymphocytic hypophysitis9.9
44patterson pseudoleprechaunism syndrome9.9
45proteinuria9.9
46endotheliitis9.9
47ehlers-danlos syndrome due to tenascin-x deficiency9.9

Graphical network of the top 20 diseases related to Adrenal Gland Hyperfunction:



Diseases related to adrenal gland hyperfunction

Symptoms for Adrenal Gland Hyperfunction

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Drugs & Therapeutics for Adrenal Gland Hyperfunction

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Drug clinical trials:

Search ClinicalTrials for Adrenal Gland Hyperfunction

Search NIH Clinical Center for Adrenal Gland Hyperfunction

Inferred drug relations via UMLS60/NDF-RT39:

Genetic Tests for Adrenal Gland Hyperfunction

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Anatomical Context for Adrenal Gland Hyperfunction

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MalaCards organs/tissues related to Adrenal Gland Hyperfunction:

31
Adrenal gland, Pituitary, Cortex, Skin, Adrenal cortex

Animal Models for Adrenal Gland Hyperfunction or affiliated genes

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Publications for Adrenal Gland Hyperfunction

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Variations for Adrenal Gland Hyperfunction

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Expression for genes affiliated with Adrenal Gland Hyperfunction

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Search GEO for disease gene expression data for Adrenal Gland Hyperfunction.

Pathways for genes affiliated with Adrenal Gland Hyperfunction

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Compounds for genes affiliated with Adrenal Gland Hyperfunction

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GO Terms for genes affiliated with Adrenal Gland Hyperfunction

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Products for genes affiliated with Adrenal Gland Hyperfunction

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  • Antibodies
  • Proteins
  • Lysates
  • Antibodies
  • Proteins
  • Kits and Assays

Sources for Adrenal Gland Hyperfunction

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3CDC
13ExPASy
14FMA
22GTR
23HGMD
24HMDB
25ICD10
26ICD10 via Orphanet
27ICD9CM
28IUPHAR
29KEGG
33MeSH
34MESH via Orphanet
35MGI
38NCIt
39NDF-RT
42NINDS
43Novoseek
45OMIM
46OMIM via Orphanet
50PubMed
51QIAGEN
56SNOMED-CT via Orphanet
60UMLS
61UMLS via Orphanet