MCID: ADR013
MIFTS: 36

Adrenal Gland Hyperfunction malady

Endocrine diseases category

Summaries for Adrenal Gland Hyperfunction

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43NINDS, 63Wikipedia, 32MalaCards
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NINDS:43 Cushing's syndrome, also called , is a rare endocrine disorder caused by chronic exposure of the body's tissues to excess levels of cortisol - a hormone naturally produced by the adrenal gland. Exposure to too much cortisol can occur from long-term use of synthetic glucocorticoid hormones to treat inflammatory illnesses. Pituitary adenomas (benign tumors of the pituitary gland) that secrete increased amounts of ACTH ( a substance that controls the release of cortisol) can also spur overproduction of cortisol. Tumors of the adrenal gland and ectopic ACTH syndrome (a condition in which ACTH is produced by various types of potentially malignant tumors that occur in different parts of the body) can cause similar problems with cortisol balance. Common symptoms of Cushing's syndrome include upper body obesity, severe fatigue and muscle weakness, high blood pressure, backache, elevated blood sugar, easy bruising, and bluish-red stretch marks on the skin. In women, there may be increased growth of facial and body hair, and menstrual periods may become irregular or stop completely. Neurological symptoms include difficulties with memory and neuromuscular disorders.

MalaCards: Adrenal Gland Hyperfunction, also known as hypercortisolism, is related to cushing's syndrome and hyperaldosteronism. An important gene associated with Adrenal Gland Hyperfunction is AVP (arginine vasopressin), and among its related pathways are Selected targets of CREB1 and Ovarian steroidogenesis. The drugs fludrocortisone and fluorocortisol acetate and the compounds cortisol and cortisone have been mentioned in the context of this disorder. Affiliated tissues include adrenal gland, cortex and skin.

Wikipedia:63 Adrenocortical hyperfunction is a condition where there is an overexpression of products of the adrenal... more...

Aliases & Classifications for Adrenal Gland Hyperfunction

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8Disease Ontology, 42NIH Rare Diseases, 43NINDS, 44Novoseek, 60UMLS, 56SNOMED-CT, 34MeSH
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Classifications:

Malacards categories (disease lists): (See all malacards categories)
Anatomical: Endocrine diseases


Aliases & Descriptions:

adrenal gland hyperfunction 8 42 60
hypercortisolism 8 43 44
hyperadrenalism 8 42
disorder of corticoadrenal overactivity 8
adrenocortical hyperfunction 8
overproduction of cortisol 8


External Ids:

Disease Ontology8 DOID:3947
MeSH34 D000308

Related Diseases for Adrenal Gland Hyperfunction

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17GeneCards, 18GeneDecks
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Diseases related to Adrenal Gland Hyperfunction via text searches within MalaCards or GeneCards/GeneDecks gene sharing:

(show top 50)    (show all 78)
idRelated DiseaseScoreTop Affiliating Genes
1cushing's syndrome30.5HSD11B2, PRL
2hyperaldosteronism30.3HSD11B2
3adrenal adenoma30.2HSD11B2
4pituitary adenoma30.0PRL
5hyperandrogenism30.0HSD3B1, PRL, INS
6hyperprolactinemia29.8PRL
7proteinuria29.8HSD11B2, INS
8hypothyroidism29.8AVP, INS, PRL
9adenoma10.2
10fatty liver disease10.1
11liver disease10.1
12neurogenic diabetes insipidus10.0AVP
13congestive heart failure10.0AVP
14germinoma10.0AVP
15eating disorder10.0INS
16acanthosis nigricans10.0INS
17diabetes mellitus10.0INS
18pseudohermaphroditism10.0HSD3B1
19gastroparesis10.0INS
20cholera10.0INS
21choriocarcinoma10.0HSD11B2
22leydig cell tumor10.0HSD3B1
23pituitary apoplexy10.0PRL
24empty sella syndrome10.0PRL
25sheehan syndrome10.0PRL
26anorexia nervosa10.0PRL
27duodenal ulcer10.0INS
28hypogonadotropism10.0PRL
29klinefelter's syndrome10.0PRL
30adrenocortical carcinoma10.0HSD3B1
31adenocarcinoma10.0HSD11B2
32liver cirrhosis10.0AVP, HSD11B2
33insulin resistance10.0HSD11B2, INS
34essential hypertension10.0INS, HSD11B2
35prolactinoma10.0PRL
36schizoaffective disorder10.0PRL
37glucose intolerance10.0INS
38primary hyperoxaluria10.0INS, AVP
39diabetes insipidus10.0AVP, PRL
40hyperglycemia10.0INS, HSD11B2
41craniopharyngioma10.0PRL, AVP
42hypokalemia10.0HSD11B2, INS
43panhypopituitarism10.0AVP, PRL
44growth hormone deficiency10.0INS, PRL
45pituitary gland disease10.0INS, PRL
46hyperthyroidism10.0INS, PRL
47anovulation10.0INS, PRL
48polycystic ovary syndrome10.0INS, PRL
49pituitary tumors10.0PRL, HSD11B2
50hypertension10.0AVP, INS, HSD11B2

Graphical network of the top 20 diseases related to Adrenal Gland Hyperfunction:



Diseases related to adrenal gland hyperfunction

Clinical Features for Adrenal Gland Hyperfunction

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Drugs & Therapeutics for Adrenal Gland Hyperfunction

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Sources:
5CenterWatch, 41NIH Clinical Center, 6ClinicalTrials, 60UMLS, 40NDF-RT
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Approved drugs:

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Drug clinical trials:

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Search CenterWatch for Adrenal Gland Hyperfunction

Inferred drug relations via UMLS60/NDF-RT40:

Genetic Tests for Adrenal Gland Hyperfunction

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Anatomical Context for Adrenal Gland Hyperfunction

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32MalaCards
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MalaCards organs/tissues related to Adrenal Gland Hyperfunction:

32
Adrenal gland, Cortex, Skin, Adrenal cortex, Pituitary

Animal Models for Adrenal Gland Hyperfunction or affiliated genes

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Publications for Adrenal Gland Hyperfunction

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Genetic Variations for Adrenal Gland Hyperfunction

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Expression for genes affiliated with Adrenal Gland Hyperfunction

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1BioGPS, 15Gene Expression Omnibus DataSets
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Expression patterns in normal tissues for genes affiliated with Adrenal Gland Hyperfunction

Search GEO for disease gene expression data for Adrenal Gland Hyperfunction.

Pathways for genes affiliated with Adrenal Gland Hyperfunction

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12EMD Millipore, 29KEGG, 53Reactome, 37NCBI BioSystems Database
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Compounds for genes affiliated with Adrenal Gland Hyperfunction

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Sources:
28IUPHAR, 24HMDB, 44Novoseek, 49PharmGKB, 11DrugBank, 59Tocris Bioscience, 2BitterDB
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Compounds related to Adrenal Gland Hyperfunction according to GeneCards/GeneDecks:

(show all 28)
idCompoundScoreTop Affiliating Genes
1cortisol28 2410.7HSD11B2, HSD3B1
2cortisone44 2410.6HSD11B2, INS
33beta-hydroxysteroid449.6HSD11B2, HSD3B1
4uric acid44 2410.5INS, AVP
5clomiphene citrate449.5PRL, INS
6cyproteroneacetate449.4INS, PRL
717-hydroxyprogesterone44 2410.4HSD3B1, PRL
8dehydroepiandrosterone sulfate449.4INS, PRL
9olanzapine49 44 28 11 2413.3PRL, INS
10melatonin44 59 28 11 2413.3PRL, AVP
11octreotide44 59 28 1112.3INS, PRL
12nadh44 11 2411.2HSD11B2, AVP, HSD3B1
13creatinine449.1HSD11B2, INS, AVP
14mifepristone44 59 28 1112.0HSD11B2, PRL
15dhea448.9HSD11B2, PRL, INS
16hydrocortisone44 2 59 1111.9HSD11B2, PRL, INS
17corticosterone44 59 2410.7PRL, HSD11B2
18cholesterol44 28 11 2411.7INS, HSD11B2, HSD3B1
19testosterone44 59 11 2411.7HSD3B1, PRL, INS
20progesterone44 59 28 11 2412.7HSD11B2, PRL, HSD3B1
21acth448.4INS, HSD11B2, PRL, AVP
22norepinephrine44 11 2410.4AVP, INS, PRL, HSD11B2
23steroid448.4AVP, HSD3B1, PRL, HSD11B2
24dexamethasone44 49 28 1111.4PRL, HSD11B2, INS, AVP
25arginine448.4HSD11B2, PRL, AVP, INS
26androstenedione44 249.4PRL, INS, HSD3B1, HSD11B2
27glucose448.4AVP, INS, HSD11B2, PRL
28estrogen448.3INS, HSD11B2, PRL, HSD3B1

GO Terms for genes affiliated with Adrenal Gland Hyperfunction

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16Gene Ontology
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Cellular components related to Adrenal Gland Hyperfunction according to GeneCards/GeneDecks:

idNameGO IDScoreTop Affiliating Genes
1secretory granuleGO:0301419.2AVP, PRL

Biological processes related to Adrenal Gland Hyperfunction according to GeneCards/GeneDecks:

idNameGO IDScoreTop Affiliating Genes
1positive regulation of cell growthGO:0303079.4AVP, INS
2glucocorticoid biosynthetic processGO:0067049.3HSD11B2, HSD3B1
3response to ethanolGO:0454719.2AVP, PRL
4female pregnancyGO:0075658.7PRL, HSD11B2

Molecular functions related to Adrenal Gland Hyperfunction according to GeneCards/GeneDecks:

idNameGO IDScoreTop Affiliating Genes
1hormone activityGO:0051799.1INS, PRL

Products for genes affiliated with Adrenal Gland Hyperfunction

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Sources for Adrenal Gland Hyperfunction

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3CDC
13ExPASy
14FMA
22GTR
23HGMD
24HMDB
25ICD10
26ICD10 via Orphanet
27ICD9CM
28IUPHAR
29KEGG
34MeSH
35MESH via Orphanet
36MGI
39NCIt
40NDF-RT
43NINDS
44Novoseek
46OMIM
47OMIM via Orphanet
50PubMed
51QIAGEN
57SNOMED-CT via Orphanet
60UMLS
61UMLS via Orphanet