MCID: ADR013
MIFTS: 34

Adrenal Gland Hyperfunction malady

Endocrine category

Summaries for Adrenal Gland Hyperfunction

Sources:
44NINDS, 64Wikipedia, 33MalaCards
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NINDS:44 Cushing's syndrome, also called , is a rare endocrine disorder caused by chronic exposure of the body's tissues to excess levels of cortisol - a hormone naturally produced by the adrenal gland. Exposure to too much cortisol can occur from long-term use of synthetic glucocorticoid hormones to treat inflammatory illnesses. Pituitary adenomas (benign tumors of the pituitary gland) that secrete increased amounts of ACTH ( a substance that controls the release of cortisol) can also spur overproduction of cortisol. Tumors of the adrenal gland and ectopic ACTH syndrome (a condition in which ACTH is produced by various types of potentially malignant tumors that occur in different parts of the body) can cause similar problems with cortisol balance. Common symptoms of Cushing's syndrome include upper body obesity, severe fatigue and muscle weakness, high blood pressure, backache, elevated blood sugar, easy bruising, and bluish-red stretch marks on the skin. In women, there may be increased growth of facial and body hair, and menstrual periods may become irregular or stop completely. Neurological symptoms include difficulties with memory and neuromuscular disorders.

MalaCards: Adrenal Gland Hyperfunction, also known as hypercortisolism, is related to cushing's syndrome and adrenal adenoma. An important gene associated with Adrenal Gland Hyperfunction is AVP (arginine vasopressin), and among its related pathways are Selected targets of CREB1 and Ovarian steroidogenesis. The drugs fludrocortisone and fluorocortisol acetate and the compounds cortisol and cortisone have been mentioned in the context of this disorder. Affiliated tissues include cortex, adrenal gland and skin.

Wikipedia:64 Adrenocortical hyperfunction is a condition where there is an overexpression of products of the adrenal... more...

Aliases & Classifications for Adrenal Gland Hyperfunction

Sources:
8Disease Ontology, 43NIH Rare Diseases, 61UMLS, 44NINDS, 45Novoseek, 57SNOMED-CT, 35MeSH
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Classifications:

Malacards categories (disease lists): (See all malacards categories)
Anatomical: Endocrine


Aliases & Descriptions:

adrenal gland hyperfunction 8 43 61
hypercortisolism 8 44 45
hyperadrenalism 8 43
disorder of corticoadrenal overactivity 8
adrenocortical hyperfunction 8
overproduction of cortisol 8


External Ids:

Disease Ontology8 DOID:3947
MeSH35 D000308

Related Diseases for Adrenal Gland Hyperfunction

Sources:
17GeneCards, 18GeneDecks
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Diseases related to Adrenal Gland Hyperfunction via text searches within MalaCards or GeneCards/GeneDecks gene sharing:

(show top 50)    (show all 73)
idRelated DiseaseScoreTop Affiliating Genes
1cushing's syndrome30.5HSD11B2, PRL
2adrenal adenoma30.2HSD11B2
3hyperandrogenism30.1HSD3B1, PRL, INS
4hyperprolactinemia29.9PRL
5adenoma10.2
6n syndrome10.2
7fatty liver disease10.1
8cortisone reductase deficiency10.1
9neurogenic diabetes insipidus10.0AVP
10congestive heart failure10.0AVP
11germinoma10.0AVP
12eating disorder10.0INS
13acanthosis nigricans10.0INS
14diabetes mellitus10.0INS
15pseudohermaphroditism10.0HSD3B1
16gastroparesis10.0INS
17cholera10.0INS
18hyperaldosteronism10.0HSD11B2
19choriocarcinoma10.0HSD11B2
20leydig cell tumor10.0HSD3B1
21pituitary apoplexy10.0PRL
22empty sella syndrome10.0PRL
23sheehan syndrome10.0PRL
24anorexia nervosa10.0PRL
25duodenal ulcer10.0INS
26pituitary adenoma10.0PRL
27hypogonadotropism10.0PRL
28klinefelter's syndrome10.0PRL
29adrenocortical carcinoma10.0HSD3B1
30adenocarcinoma10.0HSD11B2
31liver cirrhosis10.0AVP, HSD11B2
32insulin resistance10.0HSD11B2, INS
33essential hypertension10.0INS, HSD11B2
34prolactinoma10.0PRL
35proteinuria10.0HSD11B2, INS
36schizoaffective disorder10.0PRL
37glucose intolerance10.0INS
38primary hyperoxaluria10.0INS, AVP
39diabetes insipidus10.0AVP, PRL
40hyperglycemia10.0INS, HSD11B2
41craniopharyngioma10.0PRL, AVP
42hypokalemia10.0HSD11B2, INS
43panhypopituitarism10.0AVP, PRL
44growth hormone deficiency10.0INS, PRL
45pituitary gland disease10.0INS, PRL
46hyperthyroidism10.0INS, PRL
47anovulation10.0INS, PRL
48polycystic ovary syndrome10.0INS, PRL
49pituitary tumors10.0PRL, HSD11B2
50hypertension10.0AVP, INS, HSD11B2

Graphical network of the top 20 diseases related to Adrenal Gland Hyperfunction:



Diseases related to adrenal gland hyperfunction

Clinical Features for Adrenal Gland Hyperfunction

Drugs & Therapeutics for Adrenal Gland Hyperfunction

Sources:
5CenterWatch, 42NIH Clinical Center, 6ClinicalTrials, 61UMLS, 41NDF-RT
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Approved drugs:

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Drug clinical trials:

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Search CenterWatch for Adrenal Gland Hyperfunction

Inferred drug relations via UMLS61/NDF-RT41:

Genetic Tests for Adrenal Gland Hyperfunction

Anatomical Context for Adrenal Gland Hyperfunction

Sources:
33MalaCards
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MalaCards organs/tissues related to Adrenal Gland Hyperfunction:

33
Cortex, Adrenal gland, Skin, Adrenal cortex, Pituitary

Animal Models for Adrenal Gland Hyperfunction or affiliated genes

Sources:
28inGenious Targeting Laboratory
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Publications for Adrenal Gland Hyperfunction

Genetic Variations for Adrenal Gland Hyperfunction

Expression for genes affiliated with Adrenal Gland Hyperfunction

Sources:
1BioGPS, 15Gene Expression Omnibus DataSets
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Expression patterns in normal tissues for genes affiliated with Adrenal Gland Hyperfunction

Search GEO for disease gene expression data for Adrenal Gland Hyperfunction.

Pathways for genes affiliated with Adrenal Gland Hyperfunction

Sources:
12EMD Millipore, 30KEGG, 54Reactome, 38NCBI BioSystems Database
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Compounds for genes affiliated with Adrenal Gland Hyperfunction

Sources:
29IUPHAR, 24HMDB, 45Novoseek, 50PharmGKB, 11DrugBank, 60Tocris Bioscience, 2BitterDB
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Compounds related to Adrenal Gland Hyperfunction according to GeneCards/GeneDecks:

(show all 28)
idCompoundScoreTop Affiliating Genes
1cortisol29 2410.7HSD11B2, HSD3B1
2cortisone45 2410.6INS, HSD11B2
33beta-hydroxysteroid459.6HSD11B2, HSD3B1
4uric acid45 2410.5AVP, INS
5clomiphene citrate459.5INS, PRL
6cyproteroneacetate459.4PRL, INS
717-hydroxyprogesterone45 2410.4HSD3B1, PRL
8dehydroepiandrosterone sulfate459.4INS, PRL
9olanzapine50 45 29 11 2413.3PRL, INS
10melatonin45 60 29 11 2413.3AVP, PRL
11octreotide45 60 29 1112.3INS, PRL
12nadh45 11 2411.2AVP, HSD11B2, HSD3B1
13creatinine459.1AVP, INS, HSD11B2
14mifepristone45 60 29 1112.0PRL, HSD11B2
15dhea458.9INS, PRL, HSD11B2
16hydrocortisone45 2 60 1111.9HSD11B2, PRL, INS
17corticosterone45 60 2410.7PRL, HSD11B2
18cholesterol45 29 11 2411.7HSD3B1, HSD11B2, INS
19testosterone45 60 11 2411.7HSD3B1, PRL, INS
20progesterone45 60 29 11 2412.7PRL, HSD11B2, HSD3B1
21acth458.4HSD11B2, PRL, INS, AVP
22norepinephrine45 11 2410.4HSD11B2, PRL, INS, AVP
23steroid458.4HSD3B1, HSD11B2, PRL, AVP
24dexamethasone45 50 29 1111.4AVP, INS, PRL, HSD11B2
25arginine458.4HSD11B2, PRL, INS, AVP
26androstenedione45 249.4INS, PRL, HSD11B2, HSD3B1
27glucose458.4HSD11B2, PRL, INS, AVP
28estrogen458.3HSD3B1, HSD11B2, PRL, INS

GO Terms for genes affiliated with Adrenal Gland Hyperfunction

Sources:
16Gene Ontology
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Cellular components related to Adrenal Gland Hyperfunction according to GeneCards/GeneDecks:

idNameGO IDScoreTop Affiliating Genes
1secretory granuleGO:0301419.2AVP, PRL

Biological processes related to Adrenal Gland Hyperfunction according to GeneCards/GeneDecks:

idNameGO IDScoreTop Affiliating Genes
1positive regulation of cell growthGO:0303079.4AVP, INS
2glucocorticoid biosynthetic processGO:0067049.3HSD11B2, HSD3B1
3response to ethanolGO:0454719.2AVP, PRL
4female pregnancyGO:0075658.7PRL, HSD11B2

Molecular functions related to Adrenal Gland Hyperfunction according to GeneCards/GeneDecks:

idNameGO IDScoreTop Affiliating Genes
1hormone activityGO:0051799.1INS, PRL

Products for genes affiliated with Adrenal Gland Hyperfunction

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Sources for Adrenal Gland Hyperfunction

3CDC
13ExPASy
14FMA
22GTR
23HGMD
24HMDB
25ICD10
26ICD10 via Orphanet
27ICD9CM
29IUPHAR
30KEGG
35MeSH
36MESH via Orphanet
37MGI
40NCIt
41NDF-RT
44NINDS
45Novoseek
47OMIM
48OMIM via Orphanet
51PubMed
52QIAGEN
58SNOMED-CT via Orphanet
61UMLS
62UMLS via Orphanet