MCID: ADR040
MIFTS: 41

Adrenal Gland Pheochromocytoma

Categories: Endocrine diseases, Cancer diseases

Aliases & Classifications for Adrenal Gland Pheochromocytoma

MalaCards integrated aliases for Adrenal Gland Pheochromocytoma:

Name: Adrenal Gland Pheochromocytoma 12 14
Pheochromocytoma 69

Classifications:



External Ids:

Disease Ontology 12 DOID:0050892
UMLS 69 C0031511

Summaries for Adrenal Gland Pheochromocytoma

Disease Ontology : 12 An adrenal medulla cancer that is characterized by overproduction of adrenaline.

MalaCards based summary : Adrenal Gland Pheochromocytoma, also known as pheochromocytoma, is related to adrenal carcinoma and pheochromocytoma, and has symptoms including tremor, headache and fever. An important gene associated with Adrenal Gland Pheochromocytoma is NOS3 (Nitric Oxide Synthase 3), and among its related pathways/superpathways are PI3K-Akt signaling pathway and Development HGF signaling pathway. The drugs Doxazosin and Phenoxybenzamine have been mentioned in the context of this disorder. Affiliated tissues include adrenal gland, lung and liver, and related phenotypes are Dynamic nuclei (hole, folded or small irregular) and cardiovascular system

Related Diseases for Adrenal Gland Pheochromocytoma

Diseases related to Adrenal Gland Pheochromocytoma via text searches within MalaCards or GeneCards Suite gene sharing:

(show all 12)
# Related Disease Score Top Affiliating Genes
1 adrenal carcinoma 11.2
2 pheochromocytoma 10.0
3 hepatopulmonary syndrome 9.8 AKT1 NOS3
4 mitral valve disease 9.8 AKT1 NOS3
5 glucose metabolism disease 9.7 AKT1 NOS3
6 acquired metabolic disease 9.7 AKT1 NOS3
7 autosomal dominant polycystic kidney disease 9.7 MTOR NOS3
8 estrogen-receptor positive breast cancer 9.6 AKT1 MTOR
9 tuberous sclerosis 9.6 AKT1 MTOR
10 mantle cell lymphoma 9.5 AKT1 MTOR
11 kaposi sarcoma 9.3 AKT1 MTOR
12 body mass index quantitative trait locus 11 9.3 AKT1 MTOR NOS3

Graphical network of the top 20 diseases related to Adrenal Gland Pheochromocytoma:



Diseases related to Adrenal Gland Pheochromocytoma

Symptoms & Phenotypes for Adrenal Gland Pheochromocytoma

UMLS symptoms related to Adrenal Gland Pheochromocytoma:


tremor, headache, fever, chest pain, abdominal pain

GenomeRNAi Phenotypes related to Adrenal Gland Pheochromocytoma according to GeneCards Suite gene sharing:

25
# Description GenomeRNAi Source Accession Score Top Affiliating Genes
1 Dynamic nuclei (hole, folded or small irregular) GR00257-A-1 8.92 AKT1 BNIP3 MTOR NOS3

MGI Mouse Phenotypes related to Adrenal Gland Pheochromocytoma:

43
# Description MGI Source Accession Score Top Affiliating Genes
1 cardiovascular system MP:0005385 9.26 AKT1 BNIP3 MTOR NOS3
2 muscle MP:0005369 8.92 AKT1 BNIP3 MTOR NOS3

Drugs & Therapeutics for Adrenal Gland Pheochromocytoma

Drugs for Adrenal Gland Pheochromocytoma (from DrugBank, HMDB, Dgidb, PharmGKB, IUPHAR, NovoSeek, BitterDB):

(show top 50) (show all 148)
# Name Status Phase Clinical Trials Cas Number PubChem Id
1
Doxazosin Approved Phase 4,Phase 3 74191-85-8 3157
2
Phenoxybenzamine Approved Phase 4,Phase 3,Phase 2 59-96-1 4768
3 Adrenergic Agents Phase 4,Phase 3,Phase 2
4 Adrenergic alpha-1 Receptor Antagonists Phase 4,Phase 3
5 Adrenergic alpha-Antagonists Phase 4,Phase 3,Phase 2
6 Adrenergic Antagonists Phase 4,Phase 3,Phase 2
7 Antihypertensive Agents Phase 4,Phase 3,Phase 2
8 Neurotransmitter Agents Phase 4,Phase 3,Phase 2
9 Vasodilator Agents Phase 4,Phase 3,Phase 2
10
Somatostatin Approved, Investigational Phase 2, Phase 3,Phase 1 38916-34-6, 51110-01-1 53481605
11
Doxorubicin Approved, Investigational Phase 3,Phase 2 23214-92-8 31703
12
Ifosfamide Approved Phase 3 3778-73-2 3690
13
Lenograstim Approved, Investigational Phase 3 135968-09-1
14
Mechlorethamine Approved, Investigational Phase 3 51-75-2 4033
15
Doxil Approved June 1999 Phase 3,Phase 2 31703
16 3-Iodobenzylguanidine Phase 3,Phase 2,Phase 1
17 Radiopharmaceuticals Phase 3,Phase 2,Phase 1
18 Hormone Antagonists Phase 2, Phase 3,Phase 1
19 Hormones Phase 2, Phase 3,Phase 1
20 Hormones, Hormone Substitutes, and Hormone Antagonists Phase 2, Phase 3,Phase 1
21 Alkylating Agents Phase 3,Phase 2,Phase 1
22 Anti-Bacterial Agents Phase 3,Phase 2,Phase 1
23 Antibiotics, Antitubercular Phase 3,Phase 2,Phase 1
24 Isophosphamide mustard Phase 3 0
25 Topoisomerase Inhibitors Phase 3,Phase 2
26
Indinavir Approved Phase 2 150378-17-9 5362440
27
Ritonavir Approved, Investigational Phase 2 155213-67-5 392622
28
Epinephrine Approved, Vet_approved Phase 2 51-43-4 5816
29 Racepinephrine Approved Phase 2 329-65-7
30
Carbidopa Approved Phase 2 28860-95-9 38101 34359
31
Methylprednisolone Approved, Vet_approved Phase 2 83-43-2 6741
32
Prednisolone Approved, Vet_approved Phase 2 50-24-8 5755
33
Sunitinib Approved, Investigational Phase 2 341031-54-7, 557795-19-4 5329102
34
Everolimus Approved Phase 2,Phase 1 159351-69-6 6442177
35
Miconazole Approved, Investigational, Vet_approved Phase 2,Phase 1 22916-47-8 4189
36
Sirolimus Approved, Investigational Phase 2,Phase 1 53123-88-9 46835353 6436030 5284616
37
Iodine Approved, Investigational Phase 1, Phase 2 7553-56-2 807
38
Cisplatin Approved Phase 2 15663-27-1 2767 441203 84093
39
Tamoxifen Approved Phase 2 10540-29-1 2733526
40
Melphalan Approved Phase 2 148-82-3 460612 4053
41
Pancrelipase Approved, Investigational Phase 2 53608-75-6
42
Capecitabine Approved, Investigational Phase 2,Phase 1 154361-50-9 60953
43
Dacarbazine Approved, Investigational Phase 2,Phase 1 4342-03-4 5351166
44
Temozolomide Approved, Investigational Phase 2,Phase 1 85622-93-1 5394
45
Octreotide Approved, Investigational Phase 2,Phase 1 83150-76-9 6400441 383414
46
Lenvatinib Approved, Investigational Phase 2 417716-92-8
47
Azacitidine Approved, Investigational Phase 2 320-67-2 9444
48
nivolumab Approved Phase 2 946414-94-4
49
Pembrolizumab Approved Phase 2 1374853-91-4
50
Axitinib Approved, Investigational Phase 2 319460-85-0 6450551

Interventional clinical trials:

(show top 50) (show all 84)

# Name Status NCT ID Phase Drugs
1 Phenoxybenzamine Versus Doxazosin in PCC Patients Completed NCT01379898 Phase 4 Phenoxybenzamine;Doxazosin
2 Randomized Clinical Trial of Posterior Retroperitoneoscopic Adrenalectomy Versus Lateral Laparoscopic Adrenalectomy Completed NCT01959711 Phase 4
3 123I-MIBG Scintigraphy in Patients Being Evaluated for Neuroendocrine Tumors Unknown status NCT01373736 Phase 3 123I-meta-iodobenzylguanidine
4 Meta-Iodobenzylguanidine (123I mIBG) Scintigraphy in Patients Being Evaluated for Phaeochromocytoma or Neuroblastoma Completed NCT00126412 Phase 3 123I-mIBG (meta-iodobenzylguanidine)
5 Surgery With or Without Chemotherapy in Treating Patients With Soft Tissue Sarcoma Completed NCT00002641 Phase 3 doxorubicin hydrochloride;ifosfamide;isolated perfusion
6 Surgery With or Without Combination Chemotherapy in Treating Patients With Lung Metastases From Soft Tissue Sarcoma Completed NCT00002764 Phase 3 doxorubicin hydrochloride;ifosfamide
7 Safety and Efficacy Study of In-111 Pentetreotide to Treat Neuroendocrine Tumors Completed NCT00442533 Phase 2, Phase 3 Indium-111 pentetreotide
8 Preoperative Alpha Blockade for Pheochromocytoma Recruiting NCT03176693 Phase 3 Phenoxybenzamine;Doxazosin
9 177Lutetium-DOTA-Octreotate Therapy in Somatostatin Receptor-Expressing Neuroendocrine Neoplasms Unknown status NCT01237457 Phase 2 177Lu-DOTATATE
10 External-Beam Radiation Therapy With or Without Indinavir and Ritonavir in Treating Patients With Brain Metastases Unknown status NCT00637637 Phase 2 indinavir sulfate;ritonavir
11 131MIBG to Treat Malignant Pheochromocytoma Completed NCT00028106 Phase 2 [131]I-MIBG;6-[18F]Fluorodopamine;[123]I-MIBG
12 Study Of Sunitinib In Patients With Recurrent Paraganglioma/Pheochromocytoma Completed NCT00843037 Phase 2 Sunitinib
13 A Phase II Study of 131I- Metaiodobenzylguanidine (MIBG) for Treatment of Metastatic or Unresectable Pheochromocytoma and Related Tumors Completed NCT01413503 Phase 2
14 RAD001 in Pheochromocytoma or Nonfunctioning Carcinoid Completed NCT01152827 Phase 2 RAD001
15 Phase 1 Study of Iobenguane (MIBG) I 131 in Patients With Malignant Pheochromocytoma/Paraganglioma Completed NCT00458952 Phase 1, Phase 2 Ultratrace Iobenguane (MIBG) I 131
16 A Broad Multi-histology Phase II Study of the Multi-Kinase Inhibitor R935788 (Fostamatinib Disodium) in Advanced Colorectal, Non-small Cell Lung, Head and Neck Hepatocellular and Renal Cell Carcinomas, and Pheochromocytoma and Thyroid Tumors (Multi-H... Completed NCT00923481 Phase 2 Fostamatinib disodium
17 Combination Chemotherapy and Tamoxifen in Treating Patients With Solid Tumors Completed NCT00002608 Phase 2 cisplatin;doxorubicin hydrochloride;tamoxifen citrate
18 Hepatic Arterial Infusion of Melphalan With Hepatic Perfusion in Treating Patients With Unresectable Liver Cancer Completed NCT00096083 Phase 2 isolated perfusion;melphalan
19 Capecitabine and Temozolomide for Neuroendocrine Cancers Completed NCT00869050 Phase 2 Capecitabine;Temozolomide
20 RAD001 and Erlotinib in Patients With Neuroendocrine Tumors Completed NCT00843531 Phase 2 RAD001;erlotinib
21 Lenvatinib in Treating Patients With Metastatic or Advanced Pheochromocytoma or Paraganglioma That Cannot Be Removed by Surgery Recruiting NCT03008369 Phase 2 Lenvatinib
22 First International Randomized Study in Malignant Progressive Pheochromocytoma and Paraganglioma Recruiting NCT01371201 Phase 2 Sunitinib;Placebo
23 Study to Evaluate the Effects of Cabozantinib in Patients With Unresectable Metastatic Pheochromocytomas and Paragangliomas Recruiting NCT02302833 Phase 2 Cabozantinib
24 Lu-177-DOTATATE (Lutathera) in Therapy of Inoperable Pheochromocytoma/ Paraganglioma Recruiting NCT03206060 Phase 2 Lu-177-DOTATATE;Ga-68-DOTATATE;Amino Acid solution
25 Iodine I 131 Metaiodobenzylguanidine in Treating Patients With Recurrent, Progressive, or Refractory Neuroblastoma or Malignant Pheochromocytoma or Paraganglioma Recruiting NCT00107289 Phase 2
26 A Phase II Trial of the DNA Methyl Transferase Inhibitor, Guadecitabine (SGI-110), in Children and Adults With Wild Type GIST,Pheochromocytoma and Paraganglioma Associated With Succinate Dehydrogenase Deficiency and HLRCC-associated Kidney Cancer Recruiting NCT03165721 Phase 2 SGI-110 (guadecitabine)
27 Phase 2 Study of ONC201 in Neuroendocrine Tumors Recruiting NCT03034200 Phase 2 ONC201
28 MIBG Therapy for Patients With MIBG Avid Tumors Recruiting NCT02378428 Phase 2 MIBG
29 Nivolumab and Ipilimumab in Treating Patients With Rare Tumors Recruiting NCT02834013 Phase 2
30 PEN-221 in Somatostatin Receptor 2 Expressing Advanced Cancers Including Neuroendocrine and Small Cell Lung Cancers Recruiting NCT02936323 Phase 1, Phase 2 PEN-221
31 Study for the Evaluation of Efficacy of Pembrolizumab (MK-3475) in Patients With Rare Tumors Recruiting NCT02721732 Phase 2 Pembrolizumab
32 A Study Evaluating Ultratrace Iobenguane I131 in Patients With Malignant Relapsed/Refractory Pheochromocytoma/Paraganglioma Active, not recruiting NCT00874614 Phase 2
33 Phase II Study of Axitinib (AG-013736) With Evaluation of the VEGF-pathway in Metastatic, Recurrent or Primary Unresectable Pheochromocytoma/Paraganglioma Active, not recruiting NCT01967576 Phase 2 Axitinib (AG-013736)
34 Dovitinib in Neuroendocrine Tumors Active, not recruiting NCT01635907 Phase 2 Dovitinib
35 Pazopanib Hydrochloride in Treating Patients With Advanced or Progressive Malignant Pheochromocytoma or Paraganglioma Terminated NCT01340794 Phase 2 Pazopanib Hydrochloride
36 Internal Radiation Therapy in Treating Patients With Liver Metastases From Neuroendocrine Tumors Terminated NCT00466856 Phase 2 octreotide acetate
37 Parenteral Phenoxybenzamine During Congenital Heart Disease Surgery Withdrawn NCT00770705 Phase 2 Phenoxybenzamine
38 ULTRATRACE Iobenguane I 131 in Patients With Malignant Pheochromocytoma, Paraganglioma, or Metastatic Carcinoid Completed NCT00339131 Phase 1 Ultratrace iobenguane I 131
39 Radiolabeled Octreotide in Treating Children With Advanced or Refractory Solid Tumors Completed NCT00049023 Phase 1
40 Temsirolimus and Vinorelbine Ditartrate in Treating Patients With Unresectable or Metastatic Solid Tumors Completed NCT01155258 Phase 1 temsirolimus;vinorelbine ditartrate
41 Everolimus and Vatalanib in Treating Patients With Advanced Solid Tumors Completed NCT00655655 Phase 1 everolimus;vatalanib
42 Oxaliplatin With Or Without Floxuridine and Leucovorin in Treating Patients With Metastatic Cancer of the Peritoneum Completed NCT00005860 Phase 1 floxuridine;leucovorin calcium;oxaliplatin
43 Indium In 111 Pentetreotide in Treating Patients With Refractory Cancer Terminated NCT00002947 Phase 1
44 Phase I Trial of Vandetanib Combined With 131I-mIBG to Treat Patients With Advanced Phaeochromocytoma and Paraganglioma Withdrawn NCT01941849 Phase 1 Vandetanib
45 Veliparib, Capecitabine, and Temozolomide in Patients With Advanced, Metastatic, and Recurrent Neuroendocrine Tumor Withdrawn NCT02831179 Phase 1 Capecitabine;Temozolomide;Veliparib
46 Comparison of Diagnostic Performances of 68Ga-DOTATATE PET-CT and 18F-FDOPA PET-CT in Paragangliomas and Pheochromocytomas Evaluation Unknown status NCT02186678
47 Evaluation of Plasma Catecholamine Concentration During Surgery Unknown status NCT00948181
48 Quantitative Measurement of Myocardial Perfusion by Cardiac CT in Patients Unknown status NCT02361996
49 Anesthesia Management of Retroperitoneal Adrenalectomies Unknown status NCT00894335
50 Expanded Access Protocol for [123I]mIBG for Patients With Known or Suspected Neuroblastoma Approved for marketing NCT00730444 Iobenguane I 123 Injection

Search NIH Clinical Center for Adrenal Gland Pheochromocytoma

Inferred drug relations via UMLS 69 / NDF-RT 47 :


Genetic Tests for Adrenal Gland Pheochromocytoma

Anatomical Context for Adrenal Gland Pheochromocytoma

MalaCards organs/tissues related to Adrenal Gland Pheochromocytoma:

38
Adrenal Gland, Lung, Liver, Endothelial, Thyroid, Bone, Testes

Publications for Adrenal Gland Pheochromocytoma

Articles related to Adrenal Gland Pheochromocytoma:

# Title Authors Year
1
Amyloid in adrenal gland pheochromocytomas. ( 7545387 )
1995
2
Radiological seminar CCXLXII: CT of adrenal gland pheochromocytoma. ( 2778800 )
1989

Variations for Adrenal Gland Pheochromocytoma

Cosmic variations for Adrenal Gland Pheochromocytoma:

9 (show top 50) (show all 60)
# Cosmic Mut ID Gene Symbol COSMIC Disease Classification
(Primary site, Site subtype, Primary histology, Histology subtype)
Mutation CDS Mutation AA Conf
1 COSM236660 VHL adrenal gland,adrenal gland,pheochromocytoma,NS c.250G>C p.V84L 7
2 COSM17666 VHL adrenal gland,adrenal gland,pheochromocytoma,NS c.593T>C p.L198P 7
3 COSM18097 VHL adrenal gland,adrenal gland,pheochromocytoma,NS c.482G>A p.R161Q 7
4 COSM144975 VHL adrenal gland,adrenal gland,pheochromocytoma,NS c.475A>G p.K159E 7
5 COSM14311 VHL adrenal gland,adrenal gland,pheochromocytoma,NS c.499C>T p.R167W 7
6 COSM100047 VHL adrenal gland,adrenal gland,pheochromocytoma,NS c.389T>G p.V130G 7
7 COSM14283 VHL adrenal gland,adrenal gland,pheochromocytoma,NS c.491A>G p.Q164R 7
8 COSM17662 VHL adrenal gland,adrenal gland,pheochromocytoma,NS c.492G>T p.Q164H 7
9 COSM14321 VHL adrenal gland,adrenal gland,pheochromocytoma,NS c.227T>A p.F76Y 7
10 COSM5885100 VHL adrenal gland,adrenal gland,pheochromocytoma,NS c.250G>A p.V84M 7
11 COSM6444479 VHL adrenal gland,adrenal gland,pheochromocytoma,NS c.260T>C p.V87A 7
12 COSM17982 VHL adrenal gland,adrenal gland,pheochromocytoma,NS c.496G>T p.V166F 7
13 COSM10662 TP53 adrenal gland,adrenal gland,pheochromocytoma,NS c.743G>A p.R248Q 7
14 COSM44914 TP53 adrenal gland,adrenal gland,pheochromocytoma,NS c.349G>C p.G117R 7
15 COSM43678 TP53 adrenal gland,adrenal gland,pheochromocytoma,NS c.305C>T p.T102I 7
16 COSM966 RET adrenal gland,adrenal gland,pheochromocytoma,NS c.1900T>C p.C634R 7
17 COSM965 RET adrenal gland,adrenal gland,pheochromocytoma,NS c.2753T>C p.M918T 7
18 COSM329087 NF1 adrenal gland,adrenal gland,pheochromocytoma,NS c.4558C>T p.Q1520* 7
19 COSM1710108 NF1 adrenal gland,adrenal gland,pheochromocytoma,NS c.7300C>T p.Q2434* 7
20 COSM24441 NF1 adrenal gland,adrenal gland,pheochromocytoma,NS c.3721C>T p.R1241* 7
21 COSM330588 NF1 adrenal gland,adrenal gland,pheochromocytoma,NS c.2409+1G>A p.A776_Q803del 7
22 COSM330587 NF1 adrenal gland,adrenal gland,pheochromocytoma,NS c.205-1G>C p.R69fs*7 7
23 COSM220089 NF1 adrenal gland,adrenal gland,pheochromocytoma,NS c.1885G>A p.Q616fs*4 7
24 COSM329092 NF1 adrenal gland,adrenal gland,pheochromocytoma,NS c.1721+3A>T p.A548fs*13 7
25 COSM30670 NF1 adrenal gland,adrenal gland,pheochromocytoma,NS c.7646C>G p.S2549* 7
26 COSM329090 NF1 adrenal gland,adrenal gland,pheochromocytoma,NS c.226G>T p.E76* 7
27 COSM5885098 NF1 adrenal gland,adrenal gland,pheochromocytoma,NS c.5665G>T p.E1889* 7
28 COSM329093 NF1 adrenal gland,adrenal gland,pheochromocytoma,NS c.1722-1G>A p.? 7
29 COSM329089 NF1 adrenal gland,adrenal gland,pheochromocytoma,NS c.1466A>G p.Y489C 7
30 COSM327926 NF1 adrenal gland,adrenal gland,pheochromocytoma,NS c.3158C>A p.S1053* 7
31 COSM327927 NF1 adrenal gland,adrenal gland,pheochromocytoma,NS c.7582C>T p.Q2528* 7
32 COSM33676 NF1 adrenal gland,adrenal gland,pheochromocytoma,NS c.6855C>A p.Y2285* 7
33 COSM5946188 MET adrenal gland,adrenal gland,pheochromocytoma,NS c.352A>T p.M118L 7
34 COSM707 MET adrenal gland,adrenal gland,pheochromocytoma,NS c.3029C>T p.T1010I 7
35 COSM5967149 MET adrenal gland,adrenal gland,pheochromocytoma,NS c.607T>A p.S203T 7
36 COSM5945788 KMT2D adrenal gland,adrenal gland,pheochromocytoma,NS c.7954C>T p.R2652W 7
37 COSM5945782 KMT2D adrenal gland,adrenal gland,pheochromocytoma,NS c.7393G>A p.G2465S 7
38 COSM5945789 KMT2D adrenal gland,adrenal gland,pheochromocytoma,NS c.14856C>A p.N4952K 7
39 COSM5945787 KMT2D adrenal gland,adrenal gland,pheochromocytoma,NS c.11854C>G p.L3952V 7
40 COSM6342201 KMT2D adrenal gland,adrenal gland,pheochromocytoma,NS c.6797T>C p.F2266S 7
41 COSM5945783 KMT2D adrenal gland,adrenal gland,pheochromocytoma,NS c.14858A>G p.N4953S 7
42 COSM144597 KMT2D adrenal gland,adrenal gland,pheochromocytoma,NS c.7019T>C p.L2340P 7
43 COSM486 HRAS adrenal gland,adrenal gland,pheochromocytoma,NS c.37G>C p.G13R 7
44 COSM499 HRAS adrenal gland,adrenal gland,pheochromocytoma,NS c.182A>G p.Q61R 7
45 COSM496 HRAS adrenal gland,adrenal gland,pheochromocytoma,NS c.181C>A p.Q61K 7
46 COSM1732355 H3F3A adrenal gland,adrenal gland,pheochromocytoma,NS c.103G>T p.G35W 7
47 COSM27887 GNAS adrenal gland,adrenal gland,pheochromocytoma,NS c.601C>T p.R201C 7
48 COSM19176 FGFR1 adrenal gland,adrenal gland,pheochromocytoma,NS c.1638C>A p.N546K 7
49 COSM6188660 EPAS1 adrenal gland,adrenal gland,pheochromocytoma,NS c.1592C>T p.P531L 7
50 COSM6196778 EPAS1 adrenal gland,adrenal gland,pheochromocytoma,NS c.1104G>A p.M368I 7

Expression for Adrenal Gland Pheochromocytoma

Search GEO for disease gene expression data for Adrenal Gland Pheochromocytoma.

Pathways for Adrenal Gland Pheochromocytoma

Pathways related to Adrenal Gland Pheochromocytoma according to GeneCards Suite gene sharing:

(show top 50) (show all 56)
# Super pathways Score Top Affiliating Genes
1
Show member pathways
12.68 AKT1 MTOR NOS3
2
Show member pathways
12.42 AKT1 MTOR NOS3
3
Show member pathways
12.27 AKT1 MTOR NOS3
4
Show member pathways
12.15 AKT1 MTOR NOS3
5
Show member pathways
12.09 AKT1 MTOR NOS3
6
Show member pathways
11.87 AKT1 MTOR NOS3
7 11.86 AKT1 NOS3
8
Show member pathways
11.86 AKT1 BNIP3
9 11.84 AKT1 MTOR
10
Show member pathways
11.84 AKT1 MTOR NOS3
11
Show member pathways
11.81 AKT1 NOS3
12 11.8 AKT1 NOS3
13 11.79 AKT1 MTOR NOS3
14 11.78 AKT1 NOS3
15 11.77 AKT1 MTOR
16 11.75 AKT1 MTOR
17 11.71 AKT1 MTOR
18 11.7 AKT1 NOS3
19 11.68 AKT1 MTOR
20
Show member pathways
11.68 AKT1 MTOR
21 11.68 AKT1 MTOR NOS3
22 11.66 AKT1 NOS3
23 11.65 AKT1 NOS3
24
Show member pathways
11.65 AKT1 NOS3
25
Show member pathways
11.61 AKT1 MTOR
26 11.61 AKT1 MTOR
27
Show member pathways
11.61 AKT1 MTOR
28 11.6 AKT1 BNIP3 MTOR
29
Show member pathways
11.59 AKT1 NOS3
30
Show member pathways
11.56 AKT1 NOS3
31 11.55 AKT1 MTOR
32
Show member pathways
11.53 AKT1 MTOR
33 11.53 AKT1 MTOR
34 11.5 AKT1 MTOR
35 11.49 AKT1 MTOR
36
Show member pathways
11.48 AKT1 MTOR
37 11.47 AKT1 NOS3
38
Show member pathways
11.47 AKT1 MTOR NOS3
39 11.46 AKT1 MTOR
40 11.45 AKT1 MTOR
41 11.45 AKT1 BNIP3
42 11.43 AKT1 MTOR
43 11.42 AKT1 MTOR
44 11.34 AKT1 MTOR
45 11.33 AKT1 MTOR NOS3
46 11.26 AKT1 NOS3
47 11.12 AKT1 MTOR
48 11.12 AKT1 MTOR
49 11.06 AKT1 MTOR
50 11.03 AKT1 MTOR

GO Terms for Adrenal Gland Pheochromocytoma

Biological processes related to Adrenal Gland Pheochromocytoma according to GeneCards Suite gene sharing:

(show all 24)
# Name GO ID Score Top Affiliating Genes
1 cellular response to mechanical stimulus GO:0071260 9.62 AKT1 BNIP3
2 peptidyl-threonine phosphorylation GO:0018107 9.61 AKT1 MTOR
3 positive regulation of endothelial cell proliferation GO:0001938 9.61 AKT1 MTOR
4 positive regulation of smooth muscle cell proliferation GO:0048661 9.6 AKT1 MTOR
5 response to heat GO:0009408 9.59 AKT1 NOS3
6 protein catabolic process GO:0030163 9.58 AKT1 MTOR
7 positive regulation of nitric oxide biosynthetic process GO:0045429 9.58 AKT1 MTOR
8 negative regulation of autophagy GO:0010507 9.57 AKT1 MTOR
9 germ cell development GO:0007281 9.56 AKT1 MTOR
10 positive regulation of blood vessel endothelial cell migration GO:0043536 9.55 AKT1 NOS3
11 activation of protein kinase B activity GO:0032148 9.54 AKT1 MTOR
12 spinal cord development GO:0021510 9.52 AKT1 MTOR
13 lipopolysaccharide-mediated signaling pathway GO:0031663 9.51 AKT1 NOS3
14 regulation of nitric-oxide synthase activity GO:0050999 9.49 AKT1 NOS3
15 regulation of myelination GO:0031641 9.48 AKT1 MTOR
16 TOR signaling GO:0031929 9.46 AKT1 MTOR
17 negative regulation of macroautophagy GO:0016242 9.43 AKT1 MTOR
18 nitric oxide biosynthetic process GO:0006809 9.4 AKT1 NOS3
19 positive regulation of lipid biosynthetic process GO:0046889 9.37 AKT1 MTOR
20 anoikis GO:0043276 9.32 AKT1 MTOR
21 negative regulation of cell size GO:0045792 9.26 AKT1 MTOR
22 response to fluid shear stress GO:0034405 9.16 AKT1 NOS3
23 regulation of glycogen biosynthetic process GO:0005979 8.96 AKT1 MTOR
24 cellular response to hypoxia GO:0071456 8.8 AKT1 BNIP3 MTOR

Sources for Adrenal Gland Pheochromocytoma

3 CDC
7 CNVD
9 Cosmic
10 dbSNP
11 DGIdb
16 ExPASy
18 FMA
27 GO
28 GTR
29 HGMD
30 HMDB
31 HPO
32 ICD10
33 ICD10 via Orphanet
34 ICD9CM
35 IUPHAR
36 KEGG
37 LifeMap
39 MedGen
41 MeSH
42 MESH via Orphanet
43 MGI
45 NCI
46 NCIt
47 NDF-RT
50 NINDS
51 Novoseek
53 OMIM
54 OMIM via Orphanet
58 PubMed
60 QIAGEN
65 SNOMED-CT via HPO
66 SNOMED-CT via Orphanet
67 TGDB
68 Tocris
69 UMLS
70 UMLS via Orphanet
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