MCID: ADR042
MIFTS: 45

Adrenal Hyperplasia, Congenital, Due to 21-Hydroxylase Deficiency malady

Categories: Genetic diseases, Rare diseases, Reproductive diseases, Endocrine diseases, Fetal diseases

Aliases & Classifications for Adrenal Hyperplasia, Congenital, Due to 21-Hydroxylase Deficiency

About this section

Aliases & Descriptions for Adrenal Hyperplasia, Congenital, Due to 21-Hydroxylase Deficiency:

Name: Adrenal Hyperplasia, Congenital, Due to 21-Hydroxylase Deficiency 51 47 12
21-Hydroxylase Deficiency 35 70 47 25 67
21-Hydroxylase-Deficient Congenital Adrenal Hyperplasia 35 23 24
Congenital Adrenal Hyperplasia Due to 21-Hydroxylase Deficiency 47 69
Congenital Adrenal Hyperplasia 1 25 69
Virilizing Adrenal Hyperplasia 23 24
21 Hydroxylase Deficiency 47 26
Cyp21 Deficiency 47 25
Cah1 25 69
Classic Congenital Adrenal Hyperplasia Due to 21-Hydroxylase Deficiency 53
Hyperandrogenism, Nonclassic Type, Due to 21-Hydroxylase Deficiency 51
 
Hyperandrogenism Nonclassic Type Due to 21-Hydroxylase Deficiency 69
Congenital Adrenal Hyperplasia Due to 21 Hydroxylase Deficiency 25
Congenital Adrenal Hyperplasia, 21-Hydroxylase Deficient 24
Adrenal Hyperplasia Type Iii 69
Adrenal Hyperplasia 3 69
Classic 21-Ohd Cah 53
Cah, 21-Ohd 24
21-Ohd Cah 23
21-Ohd 24
Ah-Iii 69
Ah3 69

Characteristics:

Orphanet epidemiological data:

53
classic congenital adrenal hyperplasia due to 21-hydroxylase deficiency:
Inheritance: Autosomal recessive; Prevalence: 1-9/100000 (Europe); Age of onset: Antenatal,Neonatal; Age of death: any age

HPO:

63
adrenal hyperplasia, congenital, due to 21-hydroxylase deficiency:
Inheritance: autosomal recessive inheritance

Classifications:



External Ids:

OMIM51 201910
Orphanet53 ORPHA90794
ICD10 via Orphanet30 E25.0
MeSH38 D000312

Summaries for Adrenal Hyperplasia, Congenital, Due to 21-Hydroxylase Deficiency

About this section
OMIM:51 Congenital adrenal hyperplasia (CAH) results from a deficiency in one or another of the enzymes of cortisol... (201910) more...

MalaCards based summary: Adrenal Hyperplasia, Congenital, Due to 21-Hydroxylase Deficiency, also known as 21-hydroxylase deficiency, is related to classic congenital adrenal hyperplasia due to 21-hydroxylase deficiency and non-classic congenital adrenal hyperplasia due to 21-hydroxylase deficiency, and has symptoms including Array, Array and Array. An important gene associated with Adrenal Hyperplasia, Congenital, Due to 21-Hydroxylase Deficiency is CYP21A2 (Cytochrome P450 Family 21 Subfamily A Member 2). Affiliated tissues include ovary, adrenal gland and adrenal cortex.

UniProtKB/Swiss-Prot:69 Adrenal hyperplasia 3: A form of congenital adrenal hyperplasia, a common recessive disease due to defective synthesis of cortisol. Congenital adrenal hyperplasia is characterized by androgen excess leading to ambiguous genitalia in affected females, rapid somatic growth during childhood in both sexes with premature closure of the epiphyses and short adult stature. Four clinical types: 'salt wasting' (SW, the most severe type), 'simple virilizing' (SV, less severely affected patients), with normal aldosterone biosynthesis, 'non-classic form' or late-onset (NC or LOAH)and 'cryptic' (asymptomatic).

Genetics Home Reference:25 21-hydroxylase deficiency is an inherited disorder that affects the adrenal glands. The adrenal glands are located on top of the kidneys and produce a variety of hormones that regulate many essential functions in the body. In people with 21-hydroxylase deficiency, the adrenal glands produce excess androgens, which are male sex hormones.

NIH Rare Diseases:47 21-hydroxylase-deficiency is a genetic disorder of cortisol biosynthesis. It is caused by mutations in the human 21-hydroxylase gene (CYP21A2). Symptoms of 21-hydroxylase deficiency vary, but can involve salt-wasting crises in infants; ambiguous genitalia in female infants; excessive hair, deep voice, abnormal periods, no periods, and fertility problems in older girls and women; early development of masculine features in boys; and shorter than average adult height, acne, and blood pressure problems. Last updated: 2/22/2010

GeneReviews for NBK1171

Related Diseases for Adrenal Hyperplasia, Congenital, Due to 21-Hydroxylase Deficiency

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Diseases related to Adrenal Hyperplasia, Congenital, Due to 21-Hydroxylase Deficiency via text searches within MalaCards or GeneCards Suite gene sharing:

(show all 39)
idRelated DiseaseScoreTop Affiliating Genes
1classic congenital adrenal hyperplasia due to 21-hydroxylase deficiency12.0
2non-classic congenital adrenal hyperplasia due to 21-hydroxylase deficiency12.0
3classic congenital adrenal hyperplasia due to 21-hydroxylase deficiency, simple virilizing form11.8
4classic congenital adrenal hyperplasia due to 21-hydroxylase deficiency, salt wasting form11.8
53-beta-hydroxysteroid dehydrogenase-deficient congenital adrenal hyperplasia11.0
6adrenal hyperplasia, congenital, due to 11-beta-hydroxylase deficiency10.9
7infertility10.2
8hyperandrogenism10.0
9adrenal rest tumor10.0
10obesity9.9
11acne9.9
12turner syndrome9.9
13pseudohermaphroditism9.9
14adenoma9.9
15osteoporosis9.8
16male infertility9.8
17glucocorticoid-induced osteoporosis9.8
18ovarian disease9.8
19gynecomastia9.8
20cytochrome p450 oxidoreductase deficiency9.8
21precocious puberty9.8
22neuroblastoma9.7
23aromatase deficiency9.7
24androgen insensitivity9.7
25keratoconus9.7
26polycystic ovary syndrome9.7
27lymphoma9.7
28hypospadias9.7
29pyloric stenosis9.7
30gonadal dysgenesis9.7
31mixed gonadal dysgenesis9.7
32leydig cell tumor9.7
33ovarian cyst9.7
34adrenal adenoma9.7
35hyperthyroidism9.7
36polycythemia9.7
37hypopituitarism9.7
38central precocious puberty9.7
39encephalopathy9.7

Comorbidity relations with Adrenal Hyperplasia, Congenital, Due to 21-Hydroxylase Deficiency via Phenotypic Disease Network (PDN):


Hypertension, EssentialDeficiency Anemia
Acute Cystitis

Graphical network of the top 20 diseases related to Adrenal Hyperplasia, Congenital, Due to 21-Hydroxylase Deficiency:



Diseases related to adrenal hyperplasia, congenital, due to 21-hydroxylase deficiency

Symptoms for Adrenal Hyperplasia, Congenital, Due to 21-Hydroxylase Deficiency

About this section

Symptoms by clinical synopsis from OMIM:

201910

Clinical features from OMIM:

201910

Human phenotypes related to Adrenal Hyperplasia, Congenital, Due to 21-Hydroxylase Deficiency:

 53 63 (show all 73)
id Description HPO Frequency Orphanet Frequency HPO Source Accession
1 long penis53 Frequent (79-30%)
2 clitoromegaly53 Frequent (79-30%)
3 ambiguous genitalia, female53 Frequent (79-30%)
4 fused labia minora53 Frequent (79-30%)
5 renal salt wasting63 53 Occasional (29-5%) HP:0000127
6 decreased fertility53 Very frequent (99-80%)
7 abnormality of the vagina53 Frequent (79-30%)
8 polycystic ovaries53 Very frequent (99-80%)
9 aggressive behavior53 Occasional (29-5%)
10 gynecomastia63 53 Occasional (29-5%) HP:0000771
11 hypertension63 53 Frequent (79-30%) HP:0000822
12 adrenogenital syndrome63 53 Very frequent (99-80%) HP:0000840
13 increased circulating renin level53 Very frequent (99-80%)
14 insulin resistance53 Occasional (29-5%)
15 menstrual irregularities53 Very frequent (99-80%)
16 primary adrenal insufficiency53 Very frequent (99-80%)
17 decreased fertility in females53 Frequent (79-30%)
18 osteoporosis53 Very frequent (99-80%)
19 hirsutism53 Very frequent (99-80%)
20 acne53 Frequent (79-30%)
21 abnormality of prenatal development or birth53 Frequent (79-30%)
22 intellectual disability53 Occasional (29-5%)
23 failure to thrive53 Occasional (29-5%)
24 short stature53 Very frequent (99-80%)
25 obesity53 Frequent (79-30%)
26 acidosis53 Very frequent (99-80%)
27 dehydration53 Very frequent (99-80%)
28 neonatal hypoglycemia53 Very frequent (99-80%)
29 vomiting53 Very frequent (99-80%)
30 hyperkalemia53 Very frequent (99-80%)
31 hypotension53 Very frequent (99-80%)
32 accelerated bone age after puberty53 Very frequent (99-80%)
33 hyponatremia53 Very frequent (99-80%)
34 decreased circulating aldosterone level53 Very frequent (99-80%)
35 increased circulating acth level53 Very frequent (99-80%)
36 hypernatriuria53 Very frequent (99-80%)
37 reduced bone mineral density53 Very frequent (99-80%)
38 abnormality of circulating leptin level53 Frequent (79-30%)
39 abnormal oral glucose tolerance53 Frequent (79-30%)
40 aortic root dilatation53 Frequent (79-30%)
41 accelerated skeletal maturation53 Very frequent (99-80%)
42 generalized hyperpigmentation53 Frequent (79-30%)
43 maternal virilization in pregnancy53 Occasional (29-5%)
44 decreased circulating cortisol level53 Very frequent (99-80%)
45 adrenocortical adenoma53 Occasional (29-5%)
46 elevated follicle stimulating hormone53 Very frequent (99-80%)
47 adrenal medullary hypoplasia53 Occasional (29-5%)
48 congenital adrenal hyperplasia53 Very frequent (99-80%)
49 abnormal spermatogenesis53 Frequent (79-30%)
50 enlarged polycystic ovaries53 Very frequent (99-80%)
51 ambiguous genitalia53 Frequent (79-30%)
52 female pseudohermaphroditism53 Occasional (29-5%)
53 hypovolemia53 Very frequent (99-80%)
54 abnormality of hair growth rate53 Very frequent (99-80%)
55 ectopic adrenal gland53 Occasional (29-5%)
56 adrenocorticotropic hormone excess53 Frequent (79-30%)
57 feeding difficulties53 Very frequent (99-80%)
58 elevated luteinizing hormone53 Very frequent (99-80%)
59 decreased fertility in males53 Frequent (79-30%)
60 premature adrenarche53 Very frequent (99-80%)
61 abnormal scrotal rugation53 Frequent (79-30%)
62 hyperpigmented genitalia53 Frequent (79-30%)
63 increased circulating androgen level53 Very frequent (99-80%)
64 female sexual dysfunction53 Frequent (79-30%)
65 early onset of sexual maturation53 Very frequent (99-80%)
66 urogenital sinus anomaly53 Frequent (79-30%)
67 enlarged ovaries53 Very frequent (99-80%)
68 hypospadias63 HP:0000047
69 abnormality of the thorax63 HP:0000765
70 growth abnormality63 HP:0001507
71 hypoglycemia63 HP:0001943
72 fever63 HP:0001945
73 adrenal hyperplasia63 HP:0008221

Drugs & Therapeutics for Adrenal Hyperplasia, Congenital, Due to 21-Hydroxylase Deficiency

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Drugs for Adrenal Hyperplasia, Congenital, Due to 21-Hydroxylase Deficiency (from DrugBank, HMDB, Dgidb, PharmGKB, IUPHAR, NovoSeek, BitterDB):

(show top 50)    (show all 176)
idNameStatusPhaseClinical TrialsCas NumberPubChem Id
1
Hydrocortisoneapproved, vet_approvedPhase 4, Phase 3, Phase 2, Phase 164050-23-75754, 657311
Synonyms:
(11alpha,14beta)-11,17,21-trihydroxypregn-4-ene-3,20-dione
(11beta)-11,17,21-Trihydroxypregn-4-ene-3,20-dione
11-Hydrocortisone
11-beta-Hydrocortisone
11-beta-Hydroxycortisone
11a-Hydroxycorticosterone
11alpha-Hydroxycorticosterone
11b,17,21-Trihydroxyprogesterone
11b-Hydrocortisone
11b-Hydroxycortisone
11beta,17,21-Trihydroxyprogesterone
11beta,17alpha,21-Trihydroxy-4-pregnene-3,20-dione
11beta-Hydrocortisone
11beta-Hydroxycortisone
11beta-hydrocortisone
11β-hydrocortisone
17-Hydroxycorticosterone
17a-Hydroxycorticosterone
17alpha-Hydroxycorticosterone
2v95
4-Pregnen-11beta,17alpha,21-triol-3,20-dione
4-Pregnene-11alpha,21-triol 3,20-dione
4-Pregnene-11b,17a,21-triol-3,20-dione
50-23-7
8056-08-4
80562-38-5
8063-42-1
AC-12902
AC1L1L2B
ACETASOL HC
ACETIC ACID W/ HYDROCORTISONE
AI3-25006
AKOS001582651
Acticort
Acticort (TN)
Aeroseb HC
Aeroseb-HC
Ala-Cort
Ala-Scalp
Alacort
Algicirtis
Alphaderm
Amberin
Anflam
Anti-inflammatory hormone
Anucort
Anucort-HC
Anusol HC
Anusol HC (TN)
Aquacort
Aquanil HC
B48448A1-24BA-47CA-8D9E-43E5BC949386
BPBio1_000544
BRD-K93568044-001-03-1
BSPBio_000494
Balneol-hc
Barseb HC
Basan-Corti
Beta-hc
Bio-0648
C00735
C21H30O5
CCRIS 5854
CHEBI:17650
CHEMBL389621
CID5754
COR-OTICIN
CPD000653523
CaldeCORT Spray
Cetacort
Chronocort
Clear aid
Cleiton
Cobadex
Colocort
Colocort (TN)
Compound F
Compound F (kendall)
Cor-Tar-Quin
Corhydron
Cort-Dome
Cort-Quin
Cortanal
Cortef
Cortef (TN)
Cortenema
Cortesal
Corticreme
Cortifair
Cortifan
Cortifoam
Cortiment
Cortisol
Cortisol alcohol
Cortisol, Hydrocortisone
Cortisolonum
Cortisporin
Cortisporin Otico
Cortispray
Cortizol
Cortolotion
Cortonema
Cortoxide
Cortril
Cremesone
Cremicort-H
Cutisol
Cyclodextrin-encapsulated hydrocortisone
D00088
DB00741
DB07886
Delacort
Derm-Aid
Dermacort
Dermaspray
Dermil
Dermocortal
Dermolate
Dihydrocostisone
Dioderm
Dome-cort
Domolene-HC
Drotic
DuoCort
EINECS 200-020-1
EU-0100594
Ef corlin
Efcorbin
Efcortelan
Efcortelin
Eldecort
Eldercort
Epicort
Epicortisol
Epiderm H
Esiderm H
Evacort
Ficortril
Fiocortril
Flexicort
Foille Insetti
Genacort
Genacort (lotion)
Glycort
Gyno-Cortisone
H 4001
H-Cort
H0135_SIGMA
H0396_SIGMA
H0888_SIGMA
H3160_SIGMA
H4001_SIGMA
H6909_SIGMA
HC
HC #1
 
HC #4
HC (HYDROCORTISONE)
HMS1569I16
HMS2090M04
HSDB 3339
HYDROCORTISONE AND ACETIC ACID
HYDROCORTISONE IN ABSORBASE
Heb Cort
Heb-Cort
Hi-cor
Hidalone
Hidro-Colisona
Hidrocortisona
Hidrocortisona [INN-Spanish]
Hycort
Hycortol
Hycortole
Hydracort
Hydrasson
Hydro-Adreson
Hydro-Colisona
Hydro-RX
Hydro-colisona
Hydrocort
Hydrocortal
Hydrocorticosterone
Hydrocortisone
Hydrocortisone (JP15/USP/INN)
Hydrocortisone Acetate
Hydrocortisone Base
Hydrocortisone Butyrate
Hydrocortisone Sodium Phosphate
Hydrocortisone Valerate
Hydrocortisone [INN:BAN:JAN]
Hydrocortisone alcohol
Hydrocortisone base
Hydrocortisone free alcohol
Hydrocortisone solution
Hydrocortisone-Water Soluble
Hydrocortisonum
Hydrocortisonum [INN-Latin]
Hydrocortistab
Hydrocortisyl
Hydrocortone
Hydroskin
Hydroxycortisone
Hysone
Hytisone
Hytone
Hytone (TN)
Hytone lotion
Idrocortisone
Idrocortisone [DCIT]
Incortin-H
Incortin-hydrogen
Kendall'S compound F
Kendall's compound F
Komed HC
Kyypakkaus
LMST02030001
LS-7439
Lacticare HC
Lacticare-HC
Lactisona
Lopac0_000594
Lubricort
MLS000069609
MLS001148103
MLS002207135
MLS002222189
Maintasone
Medicort
Meusicort
Mildison
Milliderm
MolPort-001-794-637
NCGC00022848-06
NCGC00022848-07
NCGC00022848-09
NCGC00022848-12
NCI60_000118
NSC 10483
NSC-10483
NSC10483
Neo-Cort-Dome
Neo-Cortef
Neosporin-H Ear
Nogenic HC
Nutracort
Nystaform-HC
ORLEX HC
Optef
Otalgine
Otic-Neo-Cort-Dome
Otobiotic
Otocort
Otosone-F
Pediotic Suspension
Penecort
Permicort
Polcort H
Preparation H Hydrocortisone Cream
Prepcort
Prestwick0_000447
Prestwick1_000447
Prestwick2_000447
Prestwick3_000447
Prestwick_265
Prevex HC
Proctocort
Proctofoam
Proctozone HC
Protocort
Racet
Rectasol-HC
Rectoid
Reichstein'S substance M
Reichstein's substance M
Remederm HC
S1696_Selleck
SAM002264617
SMP1_000156
SMR000059022
SMR000653523
SPBio_002433
Sanatison
Scalp-Cort
Scalpicin Capilar
Schericur
Scheroson F
Sigmacort
Signef
Stie-cort
Stiefcorcil
Synacort
Systral Hydrocort
Tarcortin
Texacort
Texacort lotion 25
Timocort
Topicort
Transderma H
Traumaide
UNII-WI4X0X7BPJ
UPCMLD-DP133
UPCMLD-DP133:001
Uniderm
Vioform-Hydrocortisone
VoSol HC
Vytone
Zenoxone
[3H]cortisol
component of Lubricort
component of Neo-Cort-Dome
component of Otalgine
hydrocortisone
2
Estradiolapproved, investigational, vet_approvedPhase 4, Phase 2128350-28-25757, 53477783
Synonyms:
(+)-3,17b-Estradiol
(17b)-Estra-1,3,5(10)-triene-3,17-diol
(17beta)-Estra-1,3,5(10)-triene-3,17-diol
.alpha.-Estradiol
.alpha.-Oestradiol
.beta.-Estradiol
.beta.-Oestradiol
1,3,5[10]-Estratriene-3,17beta-diol 3-sulfate
1,3,5[10]-Estratriene-3,17beta-diol 3-sulphate
13b-Methyl-1,3,5(10)-gonatriene-3,17b-ol
17 beta-Estradiol
17-.BETA.-Estradiol
17-E
17-beta
17-beta-OH-estradiol
17-beta-estradiol
17.beta.-Estradiol
17.beta.-Oestradiol
17E
17b-Estradiol
17b-Oestradiol
17beta Oestradiol
17beta oestradiol
17beta-Estra-1,3,5(10)-triene-3,17-diol
17beta-Estradiol
17beta-Oestradiol
1jgl
1qkt
1qku
2d06
3,17-Epidihydroxyestratriene
3,17-beta-Estradiol
3,17-beta-Oestradiol
3,17.beta.-Estradiol
3,17b-Dihydroxyestra-1,3,5(10)-triene
3,17b-Estradiol
3,17beta-Estradiol
3,17beta-dihydroxy-1,3,5[10]-estratriene 3-sulfate
3,17beta-dihydroxy-1,3,5[10]-estratriene 3-sulphate
50-28-2
73459-61-7
873662-39-6
AC-10460
AC1L1L2K
Aerodiol
Agofollin
Alora
Altrad
Amnestrogen
Aquadiol
B-Estradiol
BEDOs
BIDD:ER0125
BIDD:PXR0065
BPBio1_000532
BSPBio_000482
BSPBio_001065
Bardiol
Benzhormovarine
Beta-estradiol
Bio-0812
Bio-E-Gel
Bio1_000403
Bio1_000892
Bio1_001381
Bio2_000363
Bio2_000843
C00951
C18H24O2
CCRIS 280
CHEBI:16469
CHEMBL135
CID5757
CMC_11154
CPD-352
CPD000059126
Climaderm
Climara
Climara (TN)
Climara Forte
Compudose
Compudose 200
Compudose 365
Corpagen
D-3,17beta-Estradiol
D-Estradiol
D-Oestradiol
D00105
DB00783
Dermestril
Destradiol
Dihydro-Theelin
Dihydrofollicular hormone
Dihydrofolliculin
Dihydromenformon
Dihydrotheelin
Dihydroxyesterin
Dihydroxyestrin
Dihydroxyoestrin
Dimenformon
Diogyn
Diogynets
Divigel
Divigel (TN)
E 2
E 8875
E(sub 2)
E0025
E1024_SIGMA
E1132_SIGMA
E2257_SIGMA
E2758_SIGMA
E8875_SIGMA
EINECS 200-023-8
EU-0100503
Elestrin
Encore
Epiestriol 50
Esclim
Estra-1,3,5(10)-triene-3,17b-diol
Estrace
Estrace (TN)
Estraderm
Estraderm (TN)
Estraderm MX
Estraderm TTS
Estraderm TTS 100
Estraderm TTS 50
Estradiol
Estradiol [USAN:INN]
Estradiol-17 beta
Estradiol-17-beta
Estradiol-17.beta.
Estradiol-17beta
Estradiol-3,17beta
Estradiolo
Estradiolo [DCIT]
Estradiolum
Estradiolum [INN]
Estradot
Estraldine
Estrapak 50
Estrasorb
Estrasorb (TN)
Estreva
Estrifam
Estring
Estring (TN)
Estring Vaginal Ring
Estring vaginal ring
Estroclim
Estroclim 50
Estrodiolum
Estrofem 2
Estrofem Forte
Estrogel
 
Estrogel (TN)
Estrogel HBF
Estrovite
Evamist
Evorel
Extrasorb
Femanest
Femestral
Femestrol
Femogen
Fempatch
Femtrace
Femtran
Follicyclin
Gelestra
Ginedisc
Ginosedol
GynPolar
Gynergon
Gynestrel
Gynodiol
Gynoestryl
HMS1362E07
HMS1569I04
HMS1792E07
HMS1990E07
HMS2051C17
HMS2090E18
HSDB 3589
IDI1_002118
Innofem
Innofem (TN)
KBio2_000405
KBio2_002269
KBio2_002973
KBio2_004837
KBio2_005541
KBio2_007405
KBio3_000769
KBio3_000770
KBio3_002749
KBioGR_000405
KBioGR_002269
KBioSS_000405
KBioSS_002270
LMST02010001
LS-137
Lamdiol
Lio-Oid
Lopac0_000503
MLS000069494
MLS000758312
MLS001076331
Macrodiol
Macrol
Menest
Menorest
Menostar
Microdiol
MolPort-001-794-632
NCGC00091544-00
NCGC00091544-01
NCGC00091544-02
NCGC00091544-04
NCGC00091544-05
NCGC00091544-06
NCGC00091544-07
NCGC00091544-08
NCGC00091544-09
NCGC00091544-12
NCGC00179321-01
NCGC00179321-02
NSC-9895
NSC9895
Nordicol
Oesclim
Oestergon
Oestra-1,3,5(10)-triene-3,17b-diol
Oestradiol
Oestradiol Berco
Oestradiol R
Oestradiol-17-beta
Oestradiol-17.beta.
Oestradiol-17beta
Oestradiolum
Oestrogel
Oestroglandol
Oestrogynal
Ovahormon
Ovasterol
Ovastevol
Ovociclina
Ovocyclin
Ovocycline
Ovocylin
Perlatanol
Polyestradiol
Prestwick0_000441
Prestwick1_000441
Prestwick2_000441
Prestwick3_000441
Prestwick_207
Primofol
Profoliol
Profoliol B
Progynon
Progynon DH
Progynon-DH
S-21400
S1709_Selleck
SAM001247032
SK-Estrogens
SL-1100
SMP1_000121
SMR000059126
SPBio_002421
Sandrena 1
Sandrena Gel
Sisare Gel
Spectrum5_002055
Syndiol
Systen
Tradelia
Trial SAT
Trocosone
UNII-4TI98Z838E
VIVELLE-DOT
Vagifem
Vagifem (TN)
Vivelle
Vivelle (TN)
Zerella
Zesteem
Zesteen
Zumenon
[2,4,6,7-3H]-E2
[3H]-estradiol
[3H]]estradiol
b-Estradiol
beta-Estradiol
beta-Estradiol 3-sulfate
beta-Estradiol 3-sulphate
bmse000642
cMAP_000005
cis-Estradiol
cis-Oestradiol
component of Menrium
delta-Estradiol
delta-Oestradiol
estradiol
estradiol-17beta
nchembio.168-comp3
nchembio.76-comp2
nchembio775-comp2
nchembio794-comp6
nchembio860-comp1
progynon
3
Ethinyl EstradiolapprovedPhase 4, Phase 271257-63-65991
Synonyms:
17 alpha-Ethinylestradiol
17 alpha-Ethynylestradiol
17 alpha-Ethynyloestradiol
17 alpha-ethinyestradiol
17-Ethinyl-3,17-estradiol
17-Ethinyl-3,17-oestradiol
17-Ethinylestradiol
17-Ethynylestradiol
17-Ethynylestradiol ram
17-Ethynyloestradiol
17-alpha-Ethinyl-17-beta-estradiol
17-alpha-Ethynyl-17-beta-oestradiol
17-alpha-Ethynylestradiol
17-alpha-Ethynylestradiol-17-beta
17-alpha-ethynyl estradiol
17-ethinyl-3,17-estradiol
17-ethinyl-3,17-oestradiol
17-ethinylestradiol
17.alpha.-Ethinyl-17.beta.-estradiol
17.alpha.-Ethinylestradiol
17.alpha.-Ethynyl-17.beta.-oestradiol
17.alpha.-Ethynylestradiol
17.alpha.-Ethynylestradiol-l7.beta.
17.alpha.-Ethynyloestradiol
17.alpha.-Ethynyloestradiol-17.beta.
17a-Ethinyl-17b-estradiol
17a-Ethinylestradiol
17a-Ethynyl-17b-oestradiol
17a-Ethynylestradiol
17a-Ethynylestradiol-l7b
17a-Ethynyloestradiol
17a-Ethynyloestradiol-17b
17alpha-Ethinyl estradiol
17alpha-Ethinylestradiol
17alpha-Ethinylestradiol-17beta
17alpha-Ethynylestradiol
17alpha-Ethynyloestradiol
17alpha-Ethynyloestradiol-17beta
17α-ethynylestradiol
406932-93-2
46263_FLUKA
46263_RIEDEL
57-63-6
77538-56-8
AC-2169
AC1L1LK6
AI3-52941
Aethinyloestradiolum
Aethinyoestradiol
Aethinyoestradiol [German]
Alora
Amenoron
Amenorone
Anovlar
BIDD:ER0162
BRN 2419975
Bio-0610
C07534
CCRIS 286
CHEBI:4903
CHEMBL691
CID5991
CPD000058319
Certostat
Chee-O-Gen
Chee-O-Genf
Cyclosa
D004997
D00554
DB00977
Dicromil
Diognat-E
Diogyn E
Diogyn-E
Diprol
Dyloform
E4876_SIGMA
EE
EE(sub 2)
EE2
EINECS 200-342-2
EO
ETHINYLESTRADIOL
Effik Brand of Ethinyl Estradiol
Ertonyl
Esclim
Esteed
Estigyn
Estinyl
Estinyl (TN)
Eston-E
Estopherol
Estoral
Estoral (Orion)
Estoral (VAN)
Estoral [Orion]
Estoral {[Orion]}
Estorals
Estradiol, Ethinyl
Estradiol, Ethynyl
Estring
Estrogen
Ethidol
Ethinoral
Ethinyl E2
Ethinyl Estradiol Hemihydrate
Ethinyl Estradiol [USP]
 
Ethinyl Estradiol, (8 alpha)-Isomer
Ethinyl Oestradiol Effik
Ethinyl estradiol
Ethinyl estradiol (USP)
Ethinyl-Oestradiol Effik
Ethinyl-Oestranol
Ethinyl-oestranol
Ethinylestradiol
Ethinylestradiol (JP15/INN)
Ethinylestradiol Jenapharm
Ethinylestradiol [INN:BAN:JAN]
Ethinylestradiolum
Ethinylestradiolum [INN-Latin]
Ethinylestriol
Ethinyloestradiol
Ethinyloestradiol [Steroidal oestrogens]
Ethy 11
Ethynyl estradiol
Ethynylestradiol
Ethynylestradiol, Ethinyl Estradiol
Ethynyloestradiol
Eticyclin
Eticyclol
Eticylol
Etinestrol
Etinestryl
Etinilestradiol
Etinilestradiol [INN-Spanish]
Etinilestradiolo
Etinilestradiolo [DCIT]
Etinoestryl
Etistradiol
Etivex
Evra
Feminone
Fempatch
Follicoral
Ginestrene
Gynodiol
Gynolett
HMS2051I19
HSDB 3587
Halodrin
Hemihydrate, Ethinyl Estradiol
Inestra
Innofem
Jenapharm Brand of Ethinyl Estradiol
Jenapharm, Ethinylestradiol
Kolpolyn
LMST02010036
LS-231
Linoral
Lynoral
MLS000028479
MLS000758274
Marvelon
Menolyn
Menostar
Mercilon
Microfollin
Microfollin Forte
MolPort-001-794-636
NCGC00091533-01
NCGC00091533-04
NCGC00091533-05
NCI60_000234
NSC-10973
NSC10973
Neo-Estrone
Nogest-S
Novestrol
OVULEN-21
OVULEN-28
Oradiol
Orestralyn
Orestrayln
Organon Brand of Ethinyl Estradiol
Ortho-Cyclen
Ovex
Oviol
PUBERTAL ETHINYL ESTRADIOL STUDY
Palonyl
Perovex
Primogyn
Primogyn C
Primogyn M
Progynon C
Progynon M
Prosexol
S1625_Selleck
SAM001247008
SGCUT00127
SMR000058319
Schering Brand of Ethinyl Estradiol
Spanestrin
Thiuram E
Thiuranide
UNII-423D2T571U
Vagifem
Varnoline
WLN: L E5 B666TTT&J E1 FQ F1UU1 OQ
Ylestrol
component of Demulen
component of Oracon
component of Ortrel
ethinyl estradiol
ethynyl estradiol
to_000048
4
DrospirenoneapprovedPhase 410267392-87-468873
Synonyms:
(6R,7R,8R,9S,10R,13S,14S,15S,16S,17S)-1,3',4',6,6a,7,8,9,10,11,12,13,14,15,15a,16-Hexadecahydro-10,13-dimethylspiro-(17H-dicyclopropa(6,7:15,16)cyclopenta(a)phenanthrene-17,2'(5'H)-furan)-3,5'(2H)-dione
1, 2-Dihydrospirorenone
1,2-Dihydrospirorenone
1,2-dihydro-spirorenone
15,16]-17alpha-pregn-4-ene-21,17-carbolactone
15-beta,16-beta-Dimethylene-3-oxo-17-alpha-pregn-4-ene-21,17-carbolactone
15beta,16beta-Dimethylene-3-oxo-17alpha-pregn-4-ene-21,17-carbolactone
15beta,16beta-dimethylene-3-oxo-17alpha-pregn-4-ene-21,17-carbolactone
17-Hydroxy-6beta,7beta:15beta,16beta-dimethylene-3-oxo-17alpha-pregn-4-ene-21-carboxylic acid, gamma-lactone
3-oxo-6alpha,7alpha,15alpha,16alpha-tetrahydro-7'H,16'H-dicyclopropa[6,7
6-beta,7-beta
67392-87-4
6beta,7Beta
6beta,7beta
6beta,7beta,15beta,16beta-dimethylen-3-oxo-17alpha-pregn-4-en-21,17-carbolacton
6beta,7beta,15beta,16beta-dimethylene-3-oxo-17alpha-pregn-4-ene-21,17 carbolactone
6β,7β,15β,16β-dimethylene-3-oxo-17α-pregn-4-ene-21,17 carbolactone
AC1L2AMM
Angeliq, Drospirenone
BRN 4765500
C035144
C24H30O3
CCRIS 6523
CHEBI:50838
 
CHEMBL1509
CID68873
D03917
DB01395
DRSP
Dehydrospirorenone
Dihydrospirorenone
Drospirenona
Drospirenona [INN-Spanish]
Drospirenona [inn-spanish]
Drospirenone
Drospirenone (JAN/USAN/INN)
Drospirenone [INN]
Drospirenonum
Drospirenonum [INN-Latin]
Drospirenonum [inn-latin]
EINECS 266-679-2
LS-146115
S1377_Selleck
SH-470
Spiro(17H-dicyclopropa(6,7:15,16)cyclopenta(a)phenanthrene-17,2'(5'H)-furan)-3,5'(2H)-dione, 1,3',4',6,7,8,9,10,11,12,13,14,15,16,20,21-hexadecahydro-10,13-dimethyl-, (6R-(6alpha,7alpha,8beta,9alpha,10beta,13beta,14alpha,15alpha,16alpha,17beta
UNII-N295J34A25
ZINC03927200
ZK 30595
ZK-30595
ZK30595
5
Cyproterone Acetateapproved, investigationalPhase 441427-51-0
Synonyms:
 
Cyproterone 17-O-acetate
6
CosyntropinapprovedPhase 42416960-16-016129617
Synonyms:
16960-16-0
ATCH (1-24)
Adrenocorticotropic hormone fragment 1-24 human, rat
COSYNTROPIN
Corticotropin tetracosapeptide
Cortrosyn
Cortrosyn (TN)
Cosyntropin
Cosyntropin (USAN)
 
D00284
Tetracosactide
Tetracosactide (INN)
Tetracosactrin
adrenocorticotropic hormone 1-24
alpha(1-24)-corticotrophin
beta(1-24)-corticotrophin
corticotropin-(1-24)
corticotropin-(1-24) tetracosapeptide
α1-24-corticotrophin
β1-24-corticotrophin
7
Epinephrineapproved, vet_approvedPhase 4, Phase 3, Phase 2, Phase 193351-43-45816
Synonyms:
(-)-(R)-Epinephrine
(-)-3,4-Dihydroxy-a-[2-(methylamino)ethyl]benzyl alcohol
(-)-3,4-Dihydroxy-alpha-((methylamino)methyl)benzyl alcohol
(-)-3,4-Dihydroxy-alpha-[2-(methylamino)ethyl]benzyl alcohol
(-)-3,4-dihydroxy-a-[(methylamino)methyl]-Benzyl alcohol
(-)-3,4-dihydroxy-alpha-[(methylamino)methyl]-Benzyl alcohol
(-)-Adrenalin
(-)-Adrenaline
(-)-Epinephrine
(-)-R-Epinephrine
(R)-(-)-Adnephrine
(R)-(-)-Adrenaline
(R)-(-)-Epinephrine
(R)-(-)-Epirenamine
(R)-(−)-adrenaline
(R)-4-[1-Hydroxy-2-(methylamino)ethyl]-1,2-benzenediol
(R)-4-[1-hydroxy-2-(methylamino)ethyl]-1,2-Benzenediol
(R)-Adrenaline
(R)-Epinephrine
(−)-adrenaline
02252_FLUKA
1-1-(3,4-Dihydroxyphenyl)-2-methylaminoethanol
1-Adrenalin
1-Epinephrine
4-(1-Hydroxy-2-(methylamino)ethyl)-1,2-benzenediol
4-(1-hydroxy-2-methylamino-ethyl)benzene-1,2-diol
4-[(1R)-1-Hydroxy-2-(methylamino)ethyl]-1,2-Benzenediol
4-[(1R)-1-Hydroxy-2-(methylamino)ethyl]-1,2-benzenediol
4-[(1R)-1-hydroxy-2-(methylamino)ethyl]benzene-1,2-diol
51-43-4
51-43-4 (FREE BASE)
51028-73-0
A0173
AC-13188
AC1L1L7B
ADR ADRENALINE
ADROP
AI3-19015
Adnephrine
Adrenal
Adrenalin
Adrenalin (TN)
Adrenalin in Oil
Adrenalin-Medihaler
Adrenalina
Adrenalina [DCIT]
Adrenaline
Adrenaline (JP15)
Adrenaline/Epinephrine
Adrenalinum
Adrenamine
Adrenan
Adrenapax
Adrenasol
Adrenatrate
Adrenine
Adrenodis
Adrenohorma
Adrenosan
Adrenutol
Adrin
Adrine
Ana-Guard
Ana-Kit
Antiasthmatique
Asmatane Mist
Asthma meter mist
Asthma-nefrin
Asthmahaler Mist
Asthmanefrin
Astmahalin
Astminhal
BIDD:GT0119
Balmadren
Bernarenin
Biorenine
Bosmin
Brevirenin
Bronkaid
Bronkaid Mist
Bronkaid Suspension Mist
Bupivacaine Hcl and Epinephrine
C00788
CCRIS 4812
CHEBI:28918
CHEMBL679
CID5816
Chelafrin
Citanest Forte
Corisol
D-Epifrin
D-Epinephrine
D00095
DB00668
Drenamist
Dylephrin
Dyspne-Inhal
E4250_SIGMA
EINECS 200-098-7
EPI E Z PEN JR
EPIPEN E Z PEN
EPIPEN JR
Epi EZ Pen Jr
Epifrin
Epiglaufrin
Epinefrin
Epinefrin [Czech]
Epinefrina
Epinefrina [INN-Spanish]
Epinephran
Epinephrin
Epinephrine
Epinephrine (USP)
Epinephrine (USP/INN)
Epinephrine [USAN:INN:JAN]
Epinephrine hydrochloride
Epinephrinum
Epinephrinum [INN-Latin]
Epipen
Epipen (TN)
Epipen Auto-Injector
Epipen EZ Pen
Epipen Jr.
Epipen Jr. Auto-Injector
Epirenamine
Epirenan
Epirenin
Epitrate
Eppy
Esphygmogenina
Exadrin
 
Glaucon
Glaucosan
Glauposine
Glycirenan
HSCI1_000215
HSDB 4289
Haemostasin
Haemostatin
Hektalin
Hemisine
Hemostasin
Hemostatin
Hypernephrin
Hyporenin
IOP
Intranefrin
Iontocaine
Isoptoepinal
Kidoline
L-1-(3,4-Dihydroxyphenyl)-2-methylaminoethanol
L-Adrenaline
L-Adrenaline Base
L-Epinehphrine
L-Epinephrine
L-Epirenamine
L-Methylaminoethanolcatechol
L-epinephrine
LS-156
Levo-Methylaminoethanolcatechol
Levoadrenaline
Levoepinephrine
Levorenen
Levorenin
Levorenine
Levoreninum
Lopac-E-4642
Lyodrin
Lyophrin
Medihaler-Epi
Metanephrin
Methylaminoethanolcatechol
Methylarterenol
Micronefrin
Micronephrine
MolPort-002-051-368
Mucidrina
Myosthenine
Mytrate
NCGC00015417-01
NCGC00142615-01
NCGC00142615-03
NCGC00142615-04
NCGC00142615-05
NCGC00142615-06
NCGC00142615-07
NSC 62786
NSC62786
Nephridine
Nieraline
PDSP1_001120
PDSP2_001104
Paranephrin
Primatene
Primatene Mist
R-(-)-Epinephrine
R-Adrenaline
RCRA waste no. P042
Racemic Epinephrine
Racepinephrine
Rcra waste number P042
Renagladin
Renaglandin
Renaglandulin
Renaleptine
Renalina
Renoform
Renostypricin
Renostypticin
Renostyptin
SMP1_000227
ST069368
SUS-PHRINE SULFITE-FREE
Scurenaline
Septocaine
Simplene
Sindrenina
Soladren
Sphygmogenin
Stryptirenal
Styptirenal
Supracapsulin
Supradin
Supranefran
Supranephrane
Supranephrine
Supranol
Suprarenaline
Suprarenin
Suprel
Surenine
Surrenine
Sus-Phrine
Sus-phrine
Susphrine
Sympathin I
Takamina
Takamine
Tokamina
Tonogen
Twinject
Twinject 0.15
Twinject 0.3
Twinject 0.30
UNII-YKH834O4BH
Vaponefrin
Vasoconstrictine
Vasoconstrictor
Vasodrine
Vasoton
Vasotonin
adrenaline
bmse000316
d-Adrenaline
epinephrine
l-1-(3,4-Dihydroxyphenyl)-2-methylaminoethanol
l-Adrenalin
l-Adrenaline
l-Epinephine
l-Epinephrine (synthetic)
l-Epirenamine
l-Methylaminoethanolcatechol
levoepinephrine
nchembio747-comp9
8
MetforminapprovedPhase 4, Phase 3, Phase 21746657-24-914219, 4091
Synonyms:
1,1-Dimethyl biguanide
1,1-Dimethylbiguanide
3-(diaminomethylidene)-1,1-dimethylguanidine
657-24-9
AC1L1HE4
AKOS000121065
Apo-Metformin
BIDD:GT0697
BPBio1_000009
BRD-K79602928-003-04-1
BSPBio_000007
BSPBio_002314
C07151
C4H11N5
CAS-1115-70-4
CCRIS 9321
CHEBI:6801
CHEMBL1431
CID4091
D04966
DB00331
DMGG
Diabetosan
Diabex
Dimethylbiguanid
Dimethylbiguanide
Dimethylbiguanidine
Dimethyldiguanide
Dimethylguanylguanidine
EINECS 211-517-8
Fluamine
Flumamine
Fortamet
Gen-Metformin
Glifage
Gliguanid
Glucophage
Glucophage XR
Glumetza
Glycon
HMS2089D19
HSCI1_000295
Haurymelin
Haurymellin
Islotin
KBio2_002310
KBio2_004878
KBio2_007446
KBio3_002790
KBioGR_002310
 
KBioSS_002312
LA-6023
LS-43899
Melbin
Metformin
Metformin (USAN/INN)
Metformin HCL
Metformin [USAN:INN:BAN]
Metformina
Metformina [DCIT]
Metformina [Spanish]
Metformine
Metformine [INN-French]
Metformine pamoate
Metforminum
Metforminum [INN-Latin]
Metiguanide
MolPort-002-929-560
MolPort-004-288-389
MolPort-005-767-418
Mylan-Metformin
N,N-Dimethylbiguanide
N,N-Dimethyldiguanide
N,N-Dimethylimidodicarbonimidic diamide
N,N-dimethylimidodicarbonimidic diamide
N1,N1-Dimethylbiguanide
NCGC00016564-01
NCGC00016564-02
NCGC00016564-03
NNDG
Novo-Metformin
Nu-Metformin
PMS-Metformin
Prestwick0_000004
Prestwick1_000004
Prestwick2_000004
Prestwick3_000004
Ran-Metformin
Ratio-Metformin
Riomet
S2483_Selleck
SPBio_001928
STK011633
Sandoz Metformin
Siofor
T5895664
Teva-Metformin
UNII-9100L32L2N
ZINC12859773
cMAP_000016
metformin
metformin hydrochloride
9
Folic Acidapproved, nutraceutical, vet_approvedPhase 4427959-30-36037
Synonyms:
(2S)-2-[[4-[(2-amino-4-oxo-1H-pteridin-6-yl)methylamino]benzoyl]amino]pentanedioic acid
01769_FLUKA
2d0k
33609-88-0
36653-55-1 (mono-potassium salt)
59-30-3
6484-89-5 (mono-hydrochloride salt)
AC-11682
AC1L1LNX
AI3-26387
AKOS000503224
ARONIS014410
Acfol (Spain)
Acide folique
Acide folique [INN-French]
Acido folico
Acido folico [INN-Spanish]
Acidum folicum
Acidum folicum [INN-Latin]
Acifolic
Antianemia factor
Apo-Folic
BIDD:ER0563
BIDD:GT0641
BIF0608
BPBio1_000654
BSPBio_000594
BSPBio_002338
C00504
C20H20N6O6
CAS-59-30-3
CCRIS 666
CHEBI:27470
CHEMBL1622
CID6037
CPD000471860
Cytofol
D00070
DB00158
DivK1c_000494
Dosfolat B activ
EINECS 200-419-0
F0043
F7876_SIAL
F7876_SIGMA
F8758_SIGMA
F8798_SIAL
F8890_SIGMA
FOL
Facid
Factor U
Folacid
Folacin
Folaemin
Folaemin [Netherlands]
Folan
Folasic (Australia)
Folate
Folbal
Folcidin
Folcidin (VAN)
Folcysteine
Foldine
Foldine [France]
Folettes
Foliamin
Folic
Folic acid
Folic acid (JP15/USP/INN)
Folic acid (TN)
Folic acid [BAN:INN:JAN]
Folic acid [INN:BAN:JAN]
Folic acid dihydrate
Folicet
Folicet (TN)
Folico
Folico (Italy)
Folina
Folina (Italy)
Folipac
Folsaeure
 
Folsan
Folsaure
Folsav
Folvite
Folvron
Glutamic acid, N-(p-(((2-amino-4-hydroxypyrimido(4,5-b)pyrazin-6-yl)methyl)amino)benzoyl)-, L
HMS1921D20
HMS2092N17
HMS501I16
HSDB 2002
IDI1_000494
InChI=1/C19H19N7O6/c20-19-25-15-14(17(30)26-19)23-11(8-22-15)7-21-10-3-1-9(2-4-10)16(29)24-12(18(31)32)5-6-13(27)28/h1-4,8,12,21H,5-7H2,(H,24,29)(H,27,28)(H,31,32)(H3,20,22,25,26,30)/t12-/m0/s
Incafolic
KBio1_000494
KBio2_001861
KBio2_004429
KBio2_006997
KBio3_001558
KBioGR_002222
KBioSS_001861
Kyselina listova
Kyselina listova [Czech]
LS-2157
Liver Lactobacillus casei factor
MLS001304016
MLS001335861
Millafol
Mission prenatal
Mittafol
MolPort-004-285-551
N-(4-(((2-Amino-1,4-dihydro-4-oxo-6-pteridinyl)methyl)amino)benzo- yl)-L-glutamic acid
N-(4-((2-Amino-1,4-dihydro-4-oxo-6-pteridinyl)methyl)amino)benzoyl)-L-glutamic acid
N-(4-{[(2-Amino-4-oxo-3,4-dihydropteridin-6-yl)methyl]amino}benzoyl)-L-glutamic acid
N-(4-{[(2-amino-4-oxo-1,4-dihydropteridin-6-yl)methyl]amino}benzoyl)-L-glutamic acid
N-(p-(((2-Amino-4-hydroxy-6-pteridinyl)methyl)amino)benzoyl)-L-glutamic acid
N-Pteroyl-L-glutamic acid
N-[(4-{[(2-Amino-4-oxo-1,4-dihydropteridin-6-yl)methyl]amino}phenyl)carbonyl]-L-glutamic acid
N-[(4-{[(2-amino-4-oxo-1,4-dihydropteridin-6-yl)methyl]amino}phenyl)carbonyl]-L-glutamic acid
N-[4-[[(2-Amino-3,4-dihydro-4-oxo-6-pteridinyl)methyl]amino]benzoyl]-L-glutamic acid
NCGC00016265-01
NCGC00142391-01
NINDS_000494
NSC 3073
Nifolin
Nifolin [Denmark]
Novofolacid
Novofolacid [Canada]
PGA
PGA (VAN)
Prestwick3_000627
Prestwick_230
PteGlu
Pteroyl-L-glutamate
Pteroyl-L-glutamic acid
Pteroyl-L-monoglutamate
Pteroyl-L-monoglutamic acid
Pteroylglutamate
Pteroylglutamic acid
Pteroylmonoglutamate
Pteroylmonoglutamic acid
SAM002264616
SDCCGMLS-0066738.P001
SMP2_000137
SMR000471860
SPBio_001357
SPECTRUM1502020
Serum Folate Level
Spectrum2_001459
Spectrum3_000749
Spectrum4_001751
Spectrum5_000602
Spectrum_001381
UNII-935E97BOY8
Usaf cb-13
Vitamin B11
Vitamin B9
Vitamin Bc
Vitamin Be
Vitamin M
bmse000299
folic acid
nchembio.108-comp10
10Diuretics, Potassium SparingPhase 41827
11Estradiol 3-benzoatePhase 4, Phase 21283
12Drospirenone and ethinyl estradiol combinationPhase 483
13Estradiol valeratePhase 4, Phase 21283979-32-8
14Estradiol 17 beta-cypionatePhase 4, Phase 21283
15MineralocorticoidsPhase 4, Phase 3, Phase 2352
16Protective AgentsPhase 47190
17Anti-Inflammatory AgentsPhase 4, Phase 2, Phase 3, Phase 110355
18Polyestradiol phosphatePhase 4, Phase 21283
19Natriuretic AgentsPhase 41645
20Mineralocorticoid Receptor AntagonistsPhase 4, Phase 3333
21diureticsPhase 41372
22HemostaticsPhase 41359
23EstrogensPhase 4, Phase 3, Phase 22470
24Hormones, Hormone Substitutes, and Hormone AntagonistsPhase 4, Phase 3, Phase 2, Phase 112767
25Hydrocortisone 17-butyrate 21-propionatePhase 4, Phase 3, Phase 2, Phase 1640
26Hydrocortisone acetatePhase 4, Phase 3, Phase 2, Phase 1640
27HormonesPhase 4, Phase 3, Phase 2, Phase 113979
28Epinephryl boratePhase 4, Phase 3, Phase 2, Phase 1933
29Cyproterone acetate, ethinyl estradiol drug combinationPhase 48
30Hormone AntagonistsPhase 4, Phase 3, Phase 2, Phase 112778
31Androgen AntagonistsPhase 4, Phase 2, Phase 1308
32RacepinephrinePhase 4, Phase 3, Phase 2, Phase 1933
33Contraceptives, OralPhase 4, Phase 21292
34Contraceptives, Oral, CombinedPhase 4, Phase 2625
35
CyproteronePhase 4412098-66-05284537
Synonyms:
(1R,3aS,3bR,7aR,8aS,8bS,8cS,10aS)-1-acetyl-5-chloro-1-hydroxy-8b,10a-dimethyl-2,3,3a,3b,7a,8,8a,8b,8c,9,10,10a-dodecahydrocyclopenta[a]cyclopropa[g]phenanthren-7(1H)-one
2098-66-0
6-Chlor-delta(6)-1,2-alpha-methylen-17-alpha-hydroxyprogesteron
6-Chlor-delta(sup 6)-1,2-alpha-methylen-17-alpha-hydroxyprogesteron
6-Chlor-delta(sup 6)-1,2-alpha-methylen-17-alpha-hydroxyprogesteron [German]
6-chloro-17-hydroxy-1beta,2beta-dihydro-3'H-cyclopropa[1,2]pregna-4,6-diene-3,20-dione
AC-6213
AC1L1EZB
AC1L27WO
Apo-cyproterone
BAY 94-8367
BAY94-8367
BSPBio_003462
C22H27ClO3
CHEBI:50742
CHEMBL142130
CID10044976
CID16417
CID3015
CID5284537
CID5702275
Ciproterona
Ciproterona Servycal
Ciproterona Servycal (TN)
Ciproterona [INN-Spanish]
Ciproterone
Ciproterone [DCIT]
CyPat
Cyproteron
Cyproterone (INN)
Cyproterone [INN:BAN]
 
Cyproterone acetate
Cyproteronum
Cyproteronum [INN-Latin]
D07766
DB04839
DivK1c_000786
Gen-Cyproterone
HMS1922K16
HMS502H08
IDI1_000786
KBio1_000786
KBio2_002052
KBio2_004620
KBio2_007188
KBio3_002966
KBioGR_001485
KBioSS_002052
LS-58798
MolPort-003-981-177
MolPort-005-932-862
NCGC00178048-01
NINDS_000786
Novo-cyproterone
SH 80881
SPBio_001594
SPECTRUM1503921
Spectrum2_001597
Spectrum3_001901
Spectrum4_000853
Spectrum5_001362
Spectrum_001572
UNII-E61Q31EK2F
cyproterone
36AndrogensPhase 4, Phase 3, Phase 2, Phase 11275
37Contraceptive Agents, MalePhase 4224
38Contraceptive AgentsPhase 4, Phase 21901
39Cortisol succinatePhase 4, Phase 3, Phase 2, Phase 1640
40AntioxidantsPhase 42928
41Vitamin B ComplexPhase 44229
42Trace ElementsPhase 45802
43VitaminsPhase 45095
44Hypoglycemic AgentsPhase 4, Phase 3, Phase 25733
45HematinicsPhase 41630
46MicronutrientsPhase 45802
47Calcium, DietaryPhase 4, Phase 3, Phase 1, Phase 25525
48Vitamin B9NutraceuticalPhase 44279
49FolateNutraceuticalPhase 44279
50Folinic AcidNutraceuticalPhase 43150

Interventional clinical trials:

(show top 50)    (show all 85)
idNameStatusNCT IDPhase
1Determination of Method-specific Normal Cortisol and Adrenal Hormone Responses to the Short Synacthen TestUnknown statusNCT00851942Phase 4
2Hemocoagulation and Lipoperoxidation in Women Using Combined Oral Contraceptives, Correction by AntioxidantsUnknown statusNCT02027337Phase 4
3Ethinyl Estradiol and Cyproterone Acetate in Irregular MenstruationUnknown statusNCT01103518Phase 4
4Low Dose OC Therapy in Women With Polycystic Ovary Syndrome (PCOS): Impact of BMI on HyperandrogenismCompletedNCT01360996Phase 4
5Effects of Metformin vs Oral Contraceptives on CV Risk Markers in PCOSCompletedNCT00428311Phase 4
6SPARTACUS: Subtyping Primary Aldosteronism: a Randomized Trial Comparing Adrenal Vein Sampling and Computed Tomography Scan.CompletedNCT01096654Phase 3
7Effect of a Commonly Used Antibiotic, Doxycycline, in Women With Polycystic Ovarian SyndromeCompletedNCT01788215Phase 3
8The Effect of Metformin Added to Clomiphene Citrate on Pregnancy Rates in Hyperandrogenic, Chronic Oligoovulatory or Anovulatory WomenCompletedNCT00413179Phase 3
9COrticosteroid in Congenital Adrenal HyperplasiaRecruitingNCT02552251Phase 2, Phase 3
10Comparison of Chronocort® With Standard Glucocorticoid Therapy in Patients With Congenital Adrenal HyperplasiaRecruitingNCT02716818Phase 3
11Extension Study for Patients Entered Into Study Infacort 003RecruitingNCT02733367Phase 3
12Dynamic Hormone Diagnostics in Endocrine DiseaseNot yet recruitingNCT02934399Phase 2, Phase 3
13Dexamethasone Treatment of Congenital Adrenal HyperplasiaCompletedNCT00621985Phase 2
14Comparison of Cortisol Pump With Standard Treatment for Congenital Adrenal HyperplasiaCompletedNCT01859312Phase 2
15Pilot Study to Characterize and Examine the Pharmacokinetics and Efficacy of Chronocort® in Adults With CAHCompletedNCT01735617Phase 2
16Comparison of Two Forms of Hydrocortisone in Patients With Congenital Adrenal HyperplasiaCompletedNCT00519818Phase 1, Phase 2
17Congenital Adrenal Hyperplasia: Calcium Channels as Therapeutic TargetsCompletedNCT00000102Phase 1, Phase 2
18Phase II Randomized Study of Leuprolide Vs Oral Contraceptive Therapy Vs Leuprolide and Oral Contraceptive Therapy for Ovarian HyperandrogenismCompletedNCT00004763Phase 2
19Treatment of Hyperandrogenism Versus Insulin Resistance in Infertile Polycystic Ovary Syndrome (PCOS) WomenCompletedNCT00704912Phase 2
20Continuous Subcutaneous Hydrocortisone Infusion in Congenital Adrenal HyperplasiaRecruitingNCT01771328Phase 2
21A Study of ATR-101 for the Treatment of Congenital Adrenal HyperplasiaRecruitingNCT02804178Phase 2
22Ultradian Subcutaneous Hydrocortisone Infusion in Addison Disease and Congenital Adrenal HyperplasiaRecruitingNCT02096510Phase 1, Phase 2
23Study of Efficacy and Safety of Osilodrostat in Cushing's SyndromeRecruitingNCT02468193Phase 2
24Acupuncture or Metformin for Insulin Resistance in Women With PCOSRecruitingNCT02647827Phase 2
25Androgen Excess as a Mechanism for Adipogenic Dysfunction in PCOS WomenRecruitingNCT01889199Phase 2
26Metformine and CC Compared With Placebo and CC for Induction Ovulation in PCOS Patients With Insulin ResistantEnrolling by invitationNCT02523898Phase 2
27A Study Examining Doses of Abiraterone Acetate in Adult Women With 21-Hydroxylase DeficiencyCompletedNCT01495910Phase 1
28Three Drug Combination Therapy Versus Conventional Treatment of Children With Congenital Adrenal HyperplasiaCompletedNCT00001521Phase 1
29An Open Label Study in Healthy Volunteers to Compare Chronocort® to HydrocortisoneCompletedNCT03019614Phase 1
30Androgen Reduction in Congenital Adrenal Hyperplasia, Phase 1Not yet recruitingNCT02574910Phase 1
31Safety, Pharmacokinetics and Pharmacodynamics of NBI-77860 in Adolescent Females With Congenital Adrenal HyperplasiaWithdrawnNCT02349503Phase 1
32Determining the Long-Term Effects of Prenatal Dexamethasone Treatment in Children With 21-Hydroxylase Deficiency and Their MothersUnknown statusNCT00617292
33Role of the Protein Osteoprotegerin in the Bone Health of Women With Congenital Adrenal HyperplasiaUnknown statusNCT00694525
34Tweens to Teens Project at Penn StateUnknown statusNCT01184651
35Mutation Analysis of 17α-HydroxylaseUnknown statusNCT00172510
36Meal Timing on Glucose and Hyperandrogenism in PCOS WomenUnknown statusNCT01711476
37Whole Genome Analysis for the Detection of Key Genes in the Polycystic Ovary SyndromeUnknown statusNCT00665171
38Examining Genetic Differences Among People With 21-Hydroxylase DeficiencyCompletedNCT00542841
39Cardiovascular Risk Profile in Patients With Congenital Adrenal HyperplasiaCompletedNCT01807364
40Study of UK Adults With Congenital Adrenal Hyperplasia.CompletedNCT00749593
41Research Study for Children With Salt Wasting Congenital Adrenal HyperplasiaCompletedNCT00529841
42Qualitative Research on Women With Congenital Adrenal HyperplasiaCompletedNCT00559078
43Effects of Pioglitazone in Congenital Adrenal HyperplasiaCompletedNCT00151710
44Catecholamine Reserve and Exercise Tolerance in Healthy Volunteers and Patients With Congenital Adrenal HyperplasiaCompletedNCT00011791
45Adrenal Hyperplasia Among Young People With PCOSCompletedNCT01313455
46Clinical Evaluation of NeoPlex4 Assay and NeoPlex SystemCompletedNCT01488721
47Arterial Stiffness Index as a Predictor of Surgically Correctable Primary AldosteronismCompletedNCT01190501
48Primary Aldosteronism in General Practice: Organ Damage, Epidemiology and TreatmentCompletedNCT01728493
49Biochemical and Radiological Indicators of Cardiovascular Morbidity in Children With Premature PubarcheCompletedNCT00581490
50To Study Polycystic Ovary Syndrome in Taiwanese WomenCompletedNCT01256944

Search NIH Clinical Center for Adrenal Hyperplasia, Congenital, Due to 21-Hydroxylase Deficiency

Genetic Tests for Adrenal Hyperplasia, Congenital, Due to 21-Hydroxylase Deficiency

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Genetic tests related to Adrenal Hyperplasia, Congenital, Due to 21-Hydroxylase Deficiency:

id Genetic test Affiliating Genes
1 21-Hydroxylase Deficiency26
2 21-Hydroxylase-Deficient Congenital Adrenal Hyperplasia24 CYP21A2

Anatomical Context for Adrenal Hyperplasia, Congenital, Due to 21-Hydroxylase Deficiency

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MalaCards organs/tissues related to Adrenal Hyperplasia, Congenital, Due to 21-Hydroxylase Deficiency:

35
Ovary, Adrenal gland, Adrenal cortex, Cortex, Skin, Kidney, Bone

Animal Models for Adrenal Hyperplasia, Congenital, Due to 21-Hydroxylase Deficiency or affiliated genes

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Publications for Adrenal Hyperplasia, Congenital, Due to 21-Hydroxylase Deficiency

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Variations for Adrenal Hyperplasia, Congenital, Due to 21-Hydroxylase Deficiency

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UniProtKB/Swiss-Prot genetic disease variations for Adrenal Hyperplasia, Congenital, Due to 21-Hydroxylase Deficiency:

69 (show all 65)
id Symbol AA change Variation ID SNP ID
1CYP21A2p.Pro30LeuVAR_001281rs9378251
2CYP21A2p.Pro105LeuVAR_001284rs550051210
3CYP21A2p.Cys169TyrVAR_001285
4CYP21A2p.Ile172AsnVAR_001286rs6475
5CYP21A2p.Ile236AsnVAR_001288rs111647200
6CYP21A2p.Val237GluVAR_001289rs12530380
7CYP21A2p.Met239LysVAR_001290rs6476
8CYP21A2p.Val281LeuVAR_001292rs6471
9CYP21A2p.Gly291SerVAR_001293rs201552310
10CYP21A2p.Arg339HisVAR_001294rs72552754
11CYP21A2p.Arg341TrpVAR_001295rs777860817
12CYP21A2p.Arg356ProVAR_001296
13CYP21A2p.Arg356GlnVAR_001297rs574370139
14CYP21A2p.Arg356TrpVAR_001298rs7769409
15CYP21A2p.Glu380AspVAR_001299rs72552756
16CYP21A2p.Pro453SerVAR_001300rs6445
17CYP21A2p.Arg483ProVAR_001301rs200005406
18CYP21A2p.Gly64GluVAR_007923
19CYP21A2p.Ala362ValVAR_007924
20CYP21A2p.His62LeuVAR_018364rs9378252
21CYP21A2p.Gly291ArgVAR_018365rs201552310
22CYP21A2p.Ser301TyrVAR_018366
23CYP21A2p.Arg341ProVAR_018367
24CYP21A2p.Arg483GlnVAR_018368rs200005406
25CYP21A2p.Ala15ThrVAR_026059rs63749090
26CYP21A2p.Pro30GlnVAR_026060
27CYP21A2p.Gly90ValVAR_026061
28CYP21A2p.Arg124HisVAR_026062rs72552750
29CYP21A2p.Gly178AlaVAR_026063rs72552751
30CYP21A2p.Val211LeuVAR_026064
31CYP21A2p.Leu261ProVAR_026065rs750337015
32CYP21A2p.Val281GlyVAR_026066
33CYP21A2p.Met283LeuVAR_026067
34CYP21A2p.Gly291CysVAR_026068
35CYP21A2p.Leu300PheVAR_026069rs765001985
36CYP21A2p.Leu317MetVAR_026071
37CYP21A2p.Arg354CysVAR_026072rs772900496
38CYP21A2p.Arg354HisVAR_026073rs760216630
39CYP21A2p.Leu363TrpVAR_026074
40CYP21A2p.His365TyrVAR_026075
41CYP21A2p.Arg408CysVAR_026077rs72552757
42CYP21A2p.Gly424SerVAR_026078rs72552758
43CYP21A2p.Arg426HisVAR_026079rs151344504
44CYP21A2p.Arg435CysVAR_026080rs767333157
45CYP21A2p.Arg479LeuVAR_026081rs184649564
46CYP21A2p.Pro482SerVAR_026082rs776989258
47CYP21A2p.Arg483TrpVAR_026083rs759736443
48CYP21A2p.Gly56ArgVAR_065668
49CYP21A2p.Ile77ThrVAR_065669
50CYP21A2p.Leu107ArgVAR_065670
51CYP21A2p.Lys121GlnVAR_065671rs547552654
52CYP21A2p.Leu142ProVAR_065672
53CYP21A2p.Leu167ProVAR_065673
54CYP21A2p.Ile230ThrVAR_065674
55CYP21A2p.Arg233LysVAR_065675
56CYP21A2p.Gly292AspVAR_065676
57CYP21A2p.Glu320LysVAR_065677
58CYP21A2p.Arg369TrpVAR_065678rs781074931
59CYP21A2p.Cys169ArgVAR_075372
60CYP21A2p.Gly178ArgVAR_075373rs772317717
61CYP21A2p.Tyr191HisVAR_075374
62CYP21A2p.Leu198PheVAR_075375rs143240527
63CYP21A2p.His282AsnVAR_075376
64CYP21A2p.Trp302ArgVAR_075377
65CYP21A2p.Arg426CysVAR_075378

Clinvar genetic disease variations for Adrenal Hyperplasia, Congenital, Due to 21-Hydroxylase Deficiency:

5 (show all 36)
id Gene Variation Type Significance SNP ID Assembly Location
1CYP21A2NM_000500.7(CYP21A2): c.92C> T (p.Pro31Leu)SNVPathogenicrs9378251GRCh37Chr 6, 32006291: 32006291
2CYP21A2NM_000500.7(CYP21A2): c.293-13C> GSNVPathogenicrs6467GRCh37Chr 6, 32006858: 32006858
3CYP21A2NM_000500.7(CYP21A2): c.874G> A (p.Gly292Ser)SNVPathogenicrs201552310GRCh37Chr 6, 32007917: 32007917
4CYP21A2NM_000500.7(CYP21A2): c.1451_1452delGGinsC (p.Arg484Profs)indelPathogenicrs397509367GRCh37Chr 6, 32008874: 32008875
5CYP21A2-4C-T, PRO105LEU, AND PRO453SERSNVPathogenicChr na, -1: -1
6CYP21A2NM_000500.7(CYP21A2): c.1360C> T (p.Pro454Ser)SNVPathogenicrs6445GRCh37Chr 6, 32008783: 32008783
7CYP21A2CYP21A2, 30-KB DELdeletionPathogenicChr na, -1: -1
8CYP21A2CYP21A2, GENE CONVERSION CYP21 FROM CYP21Pundetermined variantPathogenicChr na, -1: -1
9CYP21A2NM_000500.7(CYP21A2): c.332_339delGAGACTAC (p.Gly111Valfs)deletionPathogenicrs387906510GRCh37Chr 6, 32006910: 32006917
10CYP21A2CYP21A2, IVS7DS, G-C, +1SNVPathogenicChr na, -1: -1
11CYP21A2CYP21A2, ARG339HIS AND PRO453SERSNVPathogenicChr na, -1: -1
12CYP21A2NM_000500.7(CYP21A2): c.1217G> A (p.Trp406Ter)SNVPathogenicrs151344503GRCh37Chr 6, 32008543: 32008543
13CYP21A2CYP21A2, GLU380ASPundetermined variantPathogenicChr na, -1: -1
14CYP21A2CYP21A2, GLY424SERundetermined variantPathogenicChr na, -1: -1
15CYP21A2CYP21A2, ARG426HISundetermined variantPathogenicChr na, -1: -1
16CYP21A2CYP21A2, 1-BP INS, 82CinsertionPathogenicChr na, -1: -1
17CYP21A2CYP21A2, IVS2, A-G, -2SNVPathogenicChr na, -1: -1
18CYP21A2CYP21A2, 1-BP INS, 1003AinsertionPathogenicChr na, -1: -1
19CYP21A2CYP21A2, ARG408CYSundetermined variantPathogenicChr na, -1: -1
20CYP21A2NM_000500.7(CYP21A2): c.844G> T (p.Val282Leu)SNV, HaplotypePathogenicrs6471GRCh37Chr 6, 32007887: 32007887
21CYP21A2NM_000500.7(CYP21A2): c.188A> T (p.His63Leu)SNVPathogenicrs9378252GRCh38Chr 6, 32038610: 32038610
22CYP21A2NM_000500.7(CYP21A2): c.361A> C (p.Lys121Gln)SNVPathogenicrs267606757GRCh37Chr 6, 32006939: 32006939
23CYP21A2NM_000500.7: c.*28697972C> GSNVPathogenicChr na, -1: -1
24CYP21A2NM_000500.7: c.*28698317T> ASNVPathogenicChr na, -1: -1
25CYP21A2NM_000500.7: c.*28699001G> TSNVPathogenicChr na, -1: -1
26CYP21A2NM_000500.7: c.*28697405C> TSNVPathogenicChr na, -1: -1
27CYP21A2NM_000500.7: c.*28699312C> TSNVPathogenicChr na, -1: -1
28CYP21A2NM_000500.7: c.*28699426C> TSNVPathogenicChr na, -1: -1
29CYP21A2NM_000500.7: c.*28699080dupTduplicationLikely pathogenicChr na, -1: -1
30CYP21A2NM_000500.7: c.*28698024_*28698031del8deletionPathogenicChr na, -1: -1
31CYP21A2NM_000500.7(CYP21A2): c.710_719delTCGTGGAGATinsACGAGGAGAA (p.Ile237_Met240delinsAsnGluGluLys)indelPathogenicrs786204728GRCh38Chr 6, 32039807: 32039816
32CYP21A2NM_000500.7(CYP21A2): c.158_159delCT (p.Gln54Glufs)deletionLikely pathogenicrs886038207GRCh38Chr 6, 32038580: 32038581
33CYP21A2NM_000500.7(CYP21A2): c.518T> A (p.Ile173Asn)SNV, CompoundHeterozygotePathogenicrs6475GRCh37Chr 6, 32007203: 32007203
34CYP21A2NM_000500.5: c.293-13A> G(659A> G)undetermined variantPathogenicChr na, -1: -1
35CYP21A2NM_000500.7(CYP21A2): c.844G> C (p.Val282Leu)SNVPathogenicrs6471GRCh37Chr 6, 32007887: 32007887
36CYP21A2NM_000500.7(CYP21A2): c.923dupT (p.Leu308Phefs)duplicationPathogenicrs267606756GRCh37Chr 6, 32007966: 32007966

Expression for genes affiliated with Adrenal Hyperplasia, Congenital, Due to 21-Hydroxylase Deficiency

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Search GEO for disease gene expression data for Adrenal Hyperplasia, Congenital, Due to 21-Hydroxylase Deficiency.

Pathways for genes affiliated with Adrenal Hyperplasia, Congenital, Due to 21-Hydroxylase Deficiency

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GO Terms for genes affiliated with Adrenal Hyperplasia, Congenital, Due to 21-Hydroxylase Deficiency

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Sources for Adrenal Hyperplasia, Congenital, Due to 21-Hydroxylase Deficiency

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2CDC
6CNVD
10DGIdb
15ExPASy
16FDA
17FMA
26GTR
27HGMD
28HMDB
29ICD10
30ICD10 via Orphanet
31ICD9CM
32IUPHAR
33KEGG
36MedGen
38MeSH
39MESH via Orphanet
40MGI
43NCI
44NCIt
45NDF-RT
48NINDS
49Novoseek
51OMIM
52OMIM via Orphanet
56PubMed
57QIAGEN
62SNOMED-CT via Orphanet
66Tumor Gene Family of Databases
67UMLS
68UMLS via Orphanet