MCID: ADR003
MIFTS: 33

Adrenal Neuroblastoma malady

Neuronal, Endocrine categories

Summaries for Adrenal Neuroblastoma

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33MalaCards
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MalaCards: Adrenal Neuroblastoma, also known as neuroblastoma of adrenal gland, is related to pheochromocytoma and n syndrome. An important gene associated with Adrenal Neuroblastoma is PHOX2B (paired-like homeobox 2b), and among its related pathways is Neuroscience. The compounds vanillylmandelic acid and homovanillic acid have been mentioned in the context of this disorder. Affiliated tissues include skin, ovary and liver, and related mouse phenotypes are nervous system and behavior/neurological.

Aliases & Classifications for Adrenal Neuroblastoma

Sources:
8Disease Ontology, 10DISEASES, 61UMLS, 40NCIt, 57SNOMED-CT
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Classifications:

Malacards categories (disease lists): (See all malacards categories)
Anatomical: Neuronal, Endocrine


Aliases & Descriptions:

adrenal neuroblastoma 8 10 61
neuroblastoma of adrenal gland 8


External Ids:

Disease Ontology8 DOID:5718
SNOMED-CT57 281562007
NCIt40 C4827

Related Diseases for Adrenal Neuroblastoma

Sources:
17GeneCards, 18GeneDecks
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Graphical network of the top 20 diseases related to Adrenal Neuroblastoma:



Diseases related to adrenal neuroblastoma

Clinical Features for Adrenal Neuroblastoma

Drugs & Therapeutics for Adrenal Neuroblastoma

Sources:
5CenterWatch, 42NIH Clinical Center, 6ClinicalTrials
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Approved drugs:

Search CenterWatch for Adrenal Neuroblastoma

Drug clinical trials:

Search ClinicalTrials for Adrenal Neuroblastoma

Search NIH Clinical Center for Adrenal Neuroblastoma

Search CenterWatch for Adrenal Neuroblastoma

Genetic Tests for Adrenal Neuroblastoma

Anatomical Context for Adrenal Neuroblastoma

Sources:
33MalaCards
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MalaCards organs/tissues related to Adrenal Neuroblastoma:

33
Skin, Ovary, Liver, Brain, Lymph node, Adrenal gland, Fetal brain, Fetal liver

Animal Models for Adrenal Neuroblastoma or affiliated genes

Sources:
37MGI, 28inGenious Targeting Laboratory
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MGI Mouse Phenotypes related to Adrenal Neuroblastoma:

37
idDescriptionMGI Source AccessionScoreTop Affiliating Genes
1MP:00036317.7ENO2, KIF1A, MYCN, NTRK1, PHOX2B
2MP:00053866.9ENO2, SFPQ, PHOX2B, NTRK1, MYCN, KIF1A

Publications for Adrenal Neuroblastoma

Sources:
51PubMed
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Articles related to Adrenal Neuroblastoma:

(show top 50)    (show all 94)
idTitleAuthorsYear
1
Clinical outcomes in children with adrenal neuroblastoma undergoing open versus laparoscopic adrenalectomy. (23932613)
2013
2
Concurrent adrenal neuroblastoma and kawasaki disease: a report of a rare case. (23476867)
2013
3
Combination therapy with gefitinib and doxorubicin inhibits tumor growth in transgenic mice with adrenal neuroblastoma. (23930205)
2013
4
Long-term follow-up of the "wait and see" approach to localized perinatal adrenal neuroblastoma. (23135423)
2013
5
Bilateral hemorrhagic cystic adrenal neuroblastoma with liver and lymph nodal metastases in an infant. (23243371)
2012
6
Adrenal function in adult long-term survivors of nephroblastoma and neuroblastoma. (22513228)
2012
7
Parotid metastasis from adrenal neuroblastoma. (20571790)
2010
8
Coexistence of a giant splenic hemangioma and multiple hepatic hemangiomas mimicking a left adrenal neuroblastoma accompanied with multifocal hepatic metastases: pyrite answer. (19935098)
2009
9
Prenatally detected cystic adrenal neuroblastoma. (18279224)
2008
10
Composite adrenal anaplastic neuroblastoma and virilizing adrenocortical tumor with germline TP53 R248W mutation. (17427234)
2008
11
Simultaneous occurrence of right adrenocortical tumor and left adrenal neuroblastoma in an infant with Beckwith-Wiedemann syndrome. (18668518)
2008
12
Bilateral adrenal neuroblastoma is different. (18072022)
2007
13
Five patients with congenital adrenal hyperplasia due to 21-hydroxylase deficiency (one with associated neuroblastoma) discovered in three generations of one family. (17057407)
2007
14
Bilateral adrenal neuroblastoma: stage V disease. (17805045)
2007
15
Metastatic adrenal neuroblastoma in an adult. (15933424)
2005
16
Bilateral adrenal cystic neuroblastoma with superior vena cava syndrome and massive intracystic haemorrhage. (15164140)
2004
17
Expression of prolactin-releasing peptide and its receptor in the human adrenal glands and tumor tissues of adrenocortical tumors, pheochromocytomas and neuroblastomas. (12126742)
2002
18
Maturation of mass-screened localized adrenal neuroblastoma. (11685689)
2001
19
Laparoscopic resection of an adrenal neuroblastoma detected by mass screening that grew in size during the observation period. (10854521)
2000
20
Scrotal hematoma, anemia, and jaundice as manifestations of adrenal neuroblastoma in a newborn. (10626873)
1999
21
Cerebellin and cerebellin mRNA in the human brain, adrenal glands and the tumour tissues of adrenal tumour, ganglioneuroblastoma and neuroblastoma. (9246935)
1997
22
Clinics in diagnostic imaging (31). Adrenal neuroblastoma. (9550915)
1997
23
Delayed presentation of adrenal neuroblastoma. (8732849)
1996
24
A developmental model of neuroblastoma: differentiating stroma-poor tumors' progress along an extra-adrenal chromaffin lineage. (8941212)
1996
25
Cystic adrenal neuroblastoma: prenatal diagnosis by ultrasonography. (7990758)
1995
26
Special imaging casebook. Neonatal cystic adrenal neuroblastoma with massive hepatomegaly. (7650561)
1995
27
Prenatal diagnosis of metastatic adrenal neuroblastoma with sonography and MR imaging. (8166007)
1994
28
The real-time and color Doppler appearance of adrenal neuroblastoma in a third-trimester fetus. (8159375)
1994
29
Bilateral adrenal neuroblastoma. (8199131)
1994
30
Lymphatic drainage of adrenal neuroblastoma. (7693905)
1993
31
Ultrasonic prenatal diagnosis of liver metastases from adrenal neuroblastoma. (1328312)
1992
32
Human neuroblastoma tumor cell lines correspond to the arrested differentiation of chromaffin adrenal medullary neuroblasts. (1982060)
1990
33
Neuropeptide Y expression in the developing adrenal gland and in childhood neuroblastoma tumors. (2393870)
1990
34
The sonographic imaging of fetal adrenal neuroblastoma; a case report. (2653899)
1989
35
Antenatal sonographic diagnosis of adrenal neuroblastoma. (2939086)
1986
36
Metachronous bilateral adrenal neuroblastoma. (4027884)
1985
37
Bilateral adrenal neuroblastoma. (6711761)
1984
38
Adrenal neuroblastoma sympathicum in a 36-year-old woman. (6213415)
1982
39
Bilateral adrenal neuroblastoma. (7370961)
1980
40
Congenital hydronephrosis with ipsilateral adrenal neuroblastoma: a case report. (682257)
1978
41
Left adrenal neuroblastoma with normal-appearing urogram. (413357)
1977
42
The extra-adrenal neuroblastoma: high radiocurability and diagnostic accuracy. (4188902)
1970
43
Congenital extra-adrenal neuroblastoma. (5976574)
1966
44
MATURATION OF CONGENITAL EXTRA-ADRENAL NEUROBLASTOMA. (14048188)
1963
45
Malignant haemangioendotheliomata simulating miliary tuberculosis and neuroblastoma of the adrenal. (13554454)
1958
46
Sympathicoblastoma (adrenal neuroblastoma) with report of a case. (13042085)
1953
47
Adrenal neuroblastoma; report of five cases; new findings. (12987083)
1952
48
On adrenal neuroblastoma; report of four cases. (14829999)
1951
49
Dysgerminoma of the ovary in a 4-year-old girl with metastases clinically simulating Wilms' tumor and adrenal neuroblastoma. (18151235)
1949
50
Adrenal neuroblastoma. (20278246)
1947

Genetic Variations for Adrenal Neuroblastoma

Expression for genes affiliated with Adrenal Neuroblastoma

Sources:
1BioGPS, 15Gene Expression Omnibus DataSets
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Expression patterns in normal tissues for genes affiliated with Adrenal Neuroblastoma

Search GEO for disease gene expression data for Adrenal Neuroblastoma.

Pathways for genes affiliated with Adrenal Neuroblastoma

Sources:
4Cell Signaling Technology
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Pathways related to Adrenal Neuroblastoma according to GeneCards/GeneDecks:

idSuper pathways (with members indented)ScoreTop Affiliating Genes
18.7ENO2, MYCN, NTRK1

Compounds for genes affiliated with Adrenal Neuroblastoma

Sources:
45Novoseek, 24HMDB, 11DrugBank, 50PharmGKB, 29IUPHAR
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Compounds related to Adrenal Neuroblastoma according to GeneCards/GeneDecks:

(show all 14)
idCompoundScoreTop Affiliating Genes
1vanillylmandelic acid45 2410.8MYCN, ENO2
2homovanillic acid45 2410.7ENO2, MYCN
3cadmium45 2410.6QDPR, MYCN
4norepinephrine45 11 2411.3ENO2, QDPR, PHOX2B
5dbc-amp459.2MYCN, ENO2
6ganglioside459.0ENO2, NTRK1
7acetylcholine45 50 29 11 2412.9NTRK1, QDPR, ENO2
8paraffin458.8ENO2, MYCN, NTRK1
9cyclic amp45 249.8NTRK1, PHOX2B, SFPQ
10lactate458.7NTRK1, MYCN, ENO2
11alanine458.5PHOX2B, NTRK1, QDPR, ENO2
12catecholamine458.5ENO2, QDPR, MYCN, NTRK1
13dopamine45 29 11 2411.2PHOX2B, NTRK1, MYCN, QDPR, ENO2
14tyrosine458.1PHOX2B, NTRK1, MYCN, QDPR, ENO2

GO Terms for genes affiliated with Adrenal Neuroblastoma

Sources:
16Gene Ontology
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Biological processes related to Adrenal Neuroblastoma according to GeneCards/GeneDecks:

idNameGO IDScoreTop Affiliating Genes
1sympathetic nervous system developmentGO:0484859.3NTRK1, PHOX2B

Products for genes affiliated with Adrenal Neuroblastoma

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Sources for Adrenal Neuroblastoma

3CDC
13ExPASy
14FMA
22GTR
23HGMD
24HMDB
25ICD10
26ICD10 via Orphanet
27ICD9CM
29IUPHAR
30KEGG
35MeSH
36MESH via Orphanet
37MGI
40NCIt
41NDF-RT
44NINDS
45Novoseek
47OMIM
48OMIM via Orphanet
51PubMed
52QIAGEN
58SNOMED-CT via Orphanet
61UMLS
62UMLS via Orphanet