MCID: ADR003
MIFTS: 40

Adrenal Neuroblastoma malady

Cancer diseases, Neuronal diseases, Endocrine diseases categories
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Summaries for Adrenal Neuroblastoma

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Disease Ontology:8 An adrenal gland cancer that derives from immature neuroblastic cells.

MalaCards based summary: Adrenal Neuroblastoma, also known as neuroblastoma of adrenal gland, is related to neuroblastoma and pheochromocytoma. An important gene associated with Adrenal Neuroblastoma is PHOX2B (paired-like homeobox 2b), and among its related pathways are Transcriptional misregulation in cancer and Neuroscience. The compounds ganglioside and vanillylmandelic acid have been mentioned in the context of this disorder. Affiliated tissues include adrenal gland, liver and lymph node, and related mouse phenotypes are respiratory system and cellular.

Aliases & Classifications for Adrenal Neuroblastoma

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Adrenal Neuroblastoma, Aliases & Descriptions:

Name: Adrenal Neuroblastoma 8 10 62
 
Neuroblastoma of Adrenal Gland 8 62


Classifications:

Malacards categories (disease lists): (See all malacards categories)
Global: Cancer diseases
Anatomical: Neuronal diseases, Endocrine diseases


External Ids:

Disease Ontology8 DOID:5718
SNOMED-CT57 281562007
NCIt39 C4827

Related Diseases for Adrenal Neuroblastoma

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Diseases related to Adrenal Neuroblastoma via text searches within MalaCards or GeneCards/GeneDecks gene sharing:

(show all 42)
idRelated DiseaseScoreTop Affiliating Genes
1neuroblastoma31.0MYCN, NTRK1, ENO2, PHOX2B
2pheochromocytoma29.8ENO2, NTRK1, MYCN
3wilms tumor29.7KCNQ1OT1, MYCN, ENO2
4autonomic neuropathy10.4NTRK1
5cerebral primitive neuroectodermal tumor10.2ENO2
6hepatitis10.2
7hirschsprung's disease10.2PHOX2B, NTRK1
8ganglioglioma10.1ENO2, NTRK1
9beckwith-wiedemann syndrome10.1
10fanconi's anemia10.1
11hemangioma10.1
12hypertension10.1
13renovascular hypertension10.1
14kawasaki disease10.1
15cushing's syndrome10.1
16hydronephrosis10.1
17cervicitis10.1
18megacolon10.1
19nephroblastoma10.1
20dysgerminoma10.1
21congenital hydronephrosis10.1
22olfactory neuroblastoma10.1ENO2, NTRK1
23granular cell tumor10.0ENO2, NTRK1
24embryonal cancer10.0NTRK1, MYCN
25creutzfeldt-jakob disease10.0ENO2, NTRK1
26glioblastoma multiforme10.0NTRK1, MYCN
27alveolar rhabdomyosarcoma10.0MYCN, ENO2
28neuroepithelioma9.9ENO2, MYCN
29brain cancer9.8ENO2, MYCN
30ganglioneuroblastoma9.8ENO2, NTRK1, MYCN
31ganglioneuroma9.8ENO2, NTRK1, MYCN
32thyroid medullary carcinoma9.8MYCN, NTRK1, ENO2
33neuroendocrine tumor9.8ENO2, NTRK1, MYCN
34peripheral primitive neuroectodermal tumor9.8MYCN, NTRK1, ENO2
35rhabdomyosarcoma9.8ENO2, NTRK1, MYCN
36medulloblastoma9.8MYCN, NTRK1, ENO2
37lung small cell carcinoma9.8ENO2, NTRK1, MYCN
38sarcoma9.7ENO2, NTRK1, MYCN
39non-small cell lung carcinoma9.7MYCN, NTRK1, ENO2
40tongue squamous cell carcinoma9.7MYCN, NTRK1, ENO2
41adenocarcinoma9.6MYCN, NTRK1, ENO2
42melanoma9.5ENO2, NTRK1, MYCN

Graphical network of the top 20 diseases related to Adrenal Neuroblastoma:



Diseases related to adrenal neuroblastoma

Symptoms for Adrenal Neuroblastoma

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Drugs & Therapeutics for Adrenal Neuroblastoma

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Drug clinical trials:

Search ClinicalTrials for Adrenal Neuroblastoma

Search NIH Clinical Center for Adrenal Neuroblastoma

Genetic Tests for Adrenal Neuroblastoma

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Anatomical Context for Adrenal Neuroblastoma

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MalaCards organs/tissues related to Adrenal Neuroblastoma:

32
Adrenal gland, Liver, Lymph node, Skin, Ovary

Animal Models for Adrenal Neuroblastoma or affiliated genes

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MGI Mouse Phenotypes related to Adrenal Neuroblastoma:

36
idDescriptionMGI Source AccessionScoreTop Affiliating Genes
1MP:00053888.2KCNQ1OT1, MYCN, ENO2, PHOX2B
2MP:00053848.1PHOX2B, ENO2, MYCN, KCNQ1OT1
3MP:00053868.1PHOX2B, ENO2, KIF1A, NTRK1, MYCN
4MP:00028738.1PHOX2B, NTRK1, MYCN, KCNQ1OT1
5MP:00036318.0PHOX2B, ENO2, KIF1A, NTRK1, MYCN
6MP:00053787.6KCNQ1OT1, MYCN, NTRK1, KIF1A, PHOX2B
7MP:00107687.3KCNQ1OT1, MYCN, NTRK1, KIF1A, PHOX2B

Publications for Adrenal Neuroblastoma

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Articles related to Adrenal Neuroblastoma:

(show top 50)    (show all 84)
idTitleAuthorsYear
1
Laparoscopic resection of adrenal neuroblastoma without image-defined risk factors: a prospective study on 21 consecutive pediatric patients. (24477777)
2014
2
(18)F-FDG-PET/CT, (123)I-MIBG and (99m)Tc-MDP whole-body scans, in detecting recurrence of an adult adrenal neuroblastoma. (24563879)
2014
3
Stage 4S Bilateral Adrenal Neuroblastoma in a Newborn. (24834390)
2014
4
Prenatal diagnosis of adrenal neuroblastoma: a case report with a brief review of the literature. (23607014)
2013
5
Adrenal neuroblastoma in an adult. (23575083)
2013
6
Clinical outcomes in children with adrenal neuroblastoma undergoing open versus laparoscopic adrenalectomy. (23932613)
2013
7
Hemorrhagic shock due to spontaneous rupture of adrenal neuroblastoma in an infant: a rare case and review of the literature. (23018564)
2012
8
Prenatal diagnosis of atypical adrenal neuroblastoma with pulmonary metastases is possible: Impact on the assessment of prenatal prognosis. (22483121)
2012
9
Bilateral hemorrhagic cystic adrenal neuroblastoma with liver and lymph nodal metastases in an infant. (23243371)
2012
10
Heterochronous bilateral adrenal neuroblastoma: stage 4S in early infancy following resection of stage I lesion in the neonatal period. (22009205)
2012
11
Sudden death due to adrenal neuroblastoma: child abuse mimic? (20857235)
2011
12
Parotid metastasis from adrenal neuroblastoma. (20571790)
2010
13
Coexistence of a giant splenic hemangioma and multiple hepatic hemangiomas mimicking a left adrenal neuroblastoma accompanied with multifocal hepatic metastases: pyrite answer. (19935098)
2009
14
Prenatally detected cystic adrenal neuroblastoma. (18279224)
2008
15
Simultaneous occurrence of right adrenocortical tumor and left adrenal neuroblastoma in an infant with Beckwith-Wiedemann syndrome. (18668518)
2008
16
Case report: an unusual case of adrenal neuroblastoma in pregnancy. (18305060)
2008
17
Bilateral adrenal neuroblastoma is different. (18072022)
2007
18
Bilateral adrenal neuroblastoma: stage V disease. (17805045)
2007
19
Bilateral adrenal neuroblastoma and nephroblastoma occurring synchronously in a child with Fanconi's anemia and VACTERL syndrome. (16410081)
2006
20
Composite pheochromocytoma associated with adrenal neuroblastoma in an infant: a case report. (16481267)
2006
21
Metastatic adrenal neuroblastoma in an adult. (15933424)
2005
22
A rare case of bilateral stage IV adrenal neuroblastoma with multiple skin metastases in a neonate: diagnosis, management, and outcome. (15616928)
2004
23
Prenatal sonographic diagnosis of adrenal neuroblastoma. (11323782)
2001
24
Molecular alterations in a case of bilateral adrenal neuroblastoma. (11260574)
2001
25
Laparoscopic resection of an adrenal neuroblastoma detected by mass screening that grew in size during the observation period. (10854521)
2000
26
Paraneoplastic Cushing syndrome due to adrenal neuroblastoma. (10696137)
2000
27
Scrotal hematoma, anemia, and jaundice as manifestations of adrenal neuroblastoma in a newborn. (10626873)
1999
28
Laparoscopic resection of mass-screened adrenal neuroblastoma in an 8-month-old infant. (9438636)
1997
29
Delayed presentation of adrenal neuroblastoma. (8732849)
1996
30
Cystic adrenal neuroblastoma: prenatal diagnosis by ultrasonography. (7990758)
1995
31
Special imaging casebook. Neonatal cystic adrenal neuroblastoma with massive hepatomegaly. (7650561)
1995
32
Prenatal diagnosis of metastatic adrenal neuroblastoma with sonography and MR imaging. (8166007)
1994
33
The real-time and color Doppler appearance of adrenal neuroblastoma in a third-trimester fetus. (8159375)
1994
34
An infant with bilateral adrenal neuroblastoma found by mass-screening: report of a case. (8358199)
1993
35
Lymphatic drainage of adrenal neuroblastoma. (7693905)
1993
36
Ten-year survival following resection of an adrenal neuroblastoma with multiple liver metastases. (2102201)
1990
37
The sonographic imaging of fetal adrenal neuroblastoma; a case report. (2653899)
1989
38
Prenatal adrenal neuroblastoma. Case report with review of the literature. (3286884)
1988
39
Metachronous bilateral adrenal neuroblastoma. (4027884)
1985
40
Adult adrenal neuroblastoma with extension into inferior vena cava. (6537593)
1984
41
Left adrenal neuroblastoma with normal-appearing urogram. (413357)
1977
42
Jaw and pulpal metastasis of an adrenal neuroblastoma. (1060034)
1975
43
The extra-adrenal neuroblastoma: high radiocurability and diagnostic accuracy. (4188902)
1970
44
MATURATION OF CONGENITAL EXTRA-ADRENAL NEUROBLASTOMA. (14048188)
1963
45
Extra-adrenal neuroblastoma. (13715735)
1961
46
Foetal haemic metastasis; an explanation of the pepper-type of metastasis in adrenal neuroblastoma. (13499786)
1957
47
Sympathicoblastoma (adrenal neuroblastoma) with report of a case. (13042085)
1953
48
Adrenal neuroblastoma. (18137543)
1949
49
Dysgerminoma of the ovary in a 4-year-old girl with metastases clinically simulating Wilms' tumor and adrenal neuroblastoma. (18151235)
1949
50
Adrenal neuroblastoma. (20278246)
1947

Variations for Adrenal Neuroblastoma

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Expression for genes affiliated with Adrenal Neuroblastoma

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Expression patterns in normal tissues for genes affiliated with Adrenal Neuroblastoma

Search GEO for disease gene expression data for Adrenal Neuroblastoma.

Pathways for genes affiliated with Adrenal Neuroblastoma

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Pathways related to Adrenal Neuroblastoma according to GeneCards/GeneDecks:

idSuper pathways (with members indented)ScoreTop Affiliating Genes
19.4NTRK1, MYCN
28.9ENO2, NTRK1, MYCN

Compounds for genes affiliated with Adrenal Neuroblastoma

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Sources:
44Novoseek, 24HMDB, 11DrugBank, 28IUPHAR
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Compounds related to Adrenal Neuroblastoma according to GeneCards/GeneDecks:

(show all 16)
idCompoundScoreTop Affiliating Genes
1ganglioside449.7NTRK1, ENO2
2vanillylmandelic acid44 2410.6ENO2, MYCN
3homovanillic acid44 2410.6ENO2, MYCN
4dbc-amp449.5ENO2, MYCN
5choline44 24 1111.4ENO2, NTRK1
6bromodeoxyuridine449.3ENO2, MYCN
7glyceraldehyde 3-phosphate449.3ENO2, MYCN
8catecholamine449.2MYCN, NTRK1, ENO2
9alanine449.2NTRK1, ENO2, PHOX2B
10paraffin449.1MYCN, NTRK1, ENO2
11lactate449.1ENO2, NTRK1, MYCN
12vegf449.0MYCN, NTRK1, ENO2
13nitric oxide44 24 1111.0ENO2, NTRK1, MYCN
14dopamine44 28 24 1111.8PHOX2B, ENO2, NTRK1, MYCN
15tyrosine448.7PHOX2B, ENO2, NTRK1, MYCN
16retinoic acid44 249.6MYCN, NTRK1, ENO2

GO Terms for genes affiliated with Adrenal Neuroblastoma

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Biological processes related to Adrenal Neuroblastoma according to GeneCards/GeneDecks:

idNameGO IDScoreTop Affiliating Genes
1sympathetic nervous system developmentGO:0484859.6PHOX2B, NTRK1

Products for genes affiliated with Adrenal Neuroblastoma

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Sources for Adrenal Neuroblastoma

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3CDC
13ExPASy
14FMA
22GTR
23HGMD
24HMDB
25ICD10
26ICD10 via Orphanet
27ICD9CM
28IUPHAR
29KEGG
34MeSH
35MESH via Orphanet
36MGI
39NCIt
40NDF-RT
43NINDS
44Novoseek
46OMIM
47OMIM via Orphanet
51PubMed
52QIAGEN
58SNOMED-CT via Orphanet
62UMLS
63UMLS via Orphanet