MCID: ADR003
MIFTS: 28

Adrenal Neuroblastoma

Categories: Cancer diseases, Endocrine diseases, Neuronal diseases

Aliases & Classifications for Adrenal Neuroblastoma

MalaCards integrated aliases for Adrenal Neuroblastoma:

Name: Adrenal Neuroblastoma 12 14 69
Neuroblastoma of Adrenal Gland 12

Classifications:



External Ids:

Disease Ontology 12 DOID:5718
NCIt 47 C4827
SNOMED-CT 64 281562007
UMLS 69 C0559460

Summaries for Adrenal Neuroblastoma

Disease Ontology : 12 An adrenal gland cancer that derives from immature neuroblastic cells.

MalaCards based summary : Adrenal Neuroblastoma, also known as neuroblastoma of adrenal gland, is related to neuroblastoma and pharynx carcinoma in situ. An important gene associated with Adrenal Neuroblastoma is ENO2 (Enolase 2). The drugs Isotretinoin and Tretinoin have been mentioned in the context of this disorder. Affiliated tissues include adrenal gland, liver and ovary.

Related Diseases for Adrenal Neuroblastoma

Graphical network of the top 20 diseases related to Adrenal Neuroblastoma:



Diseases related to Adrenal Neuroblastoma

Symptoms & Phenotypes for Adrenal Neuroblastoma

Drugs & Therapeutics for Adrenal Neuroblastoma

Drugs for Adrenal Neuroblastoma (from DrugBank, HMDB, Dgidb, PharmGKB, IUPHAR, NovoSeek, BitterDB):

(show all 33)
id Name Status Phase Clinical Trials Cas Number PubChem Id
1
Isotretinoin Approved Phase 3 4759-48-2 5538 5282379
2
Tretinoin Approved, Investigational, Nutraceutical Phase 3 302-79-4 5538
3
Oxaliplatin Approved, Investigational Phase 2 61825-94-3 5310940 9887054 43805 6857599
4
Octreotide Approved, Investigational Phase 2 83150-76-9 383414 6400441
5
Somatostatin Approved Phase 2 38916-34-6, 51110-01-1 53481605
6
Pertuzumab Approved Phase 2 145040-37-5, 380610-27-5 2540
7 3-Iodobenzylguanidine Phase 2
8 Antibodies Phase 2
9 Antibodies, Monoclonal Phase 2
10 Immunoglobulins Phase 2
11 Antineoplastic Agents, Hormonal Phase 2
12 Edotreotide Phase 2
13 Gastrointestinal Agents Phase 2
14 Hormone Antagonists Phase 2
15 Hormones Phase 2
16 Hormones, Hormone Substitutes, and Hormone Antagonists Phase 2
17 Radiopharmaceuticals Phase 2
18
Erlotinib Hydrochloride Phase 2 183319-69-9 176871
19 Protein Kinase Inhibitors Phase 2
20
Cyclophosphamide Approved, Investigational Phase 1 50-18-0, 6055-19-2 2907
21
Cisplatin Approved Phase 1 15663-27-1 84093 441203 2767
22 Alkylating Agents Phase 1
23 Antirheumatic Agents Phase 1
24 Immunosuppressive Agents Phase 1
25
Epinephrine Approved, Vet_approved 51-43-4 5816
26 Racepinephrine Approved
27
Iodine Investigational 7553-56-2 807
28 Epinephryl borate
29 Anti-Infective Agents
30 Anti-Infective Agents, Local
31 cadexomer iodine
32 Micronutrients
33 Trace Elements

Interventional clinical trials:

(show all 15)

id Name Status NCT ID Phase Drugs
1 European Low and Intermediate Risk Neuroblastoma Protocol Recruiting NCT01728155 Phase 3 chemotherapy
2 Cixutumumab in Treating Patients With Relapsed or Refractory Solid Tumors Completed NCT00831844 Phase 2
3 Oxaliplatin in Treating Young Patients With Recurrent Solid Tumors That Have Not Responded to Previous Treatment Completed NCT00091182 Phase 2 oxaliplatin
4 Evaluation of Gallium-68 DOTA-TOC Imaging of Somatostatin Receptor Positive Malignancies Recruiting NCT02177773 Phase 2 DOTA-TOC PET/CT
5 A Phase II Study of Pertuzumab and Erlotinib for Metastatic or Unresectable Neuroendocrine Tumors Terminated NCT00947167 Phase 2 pertuzumab;erlotinib
6 Seneca Valley Virus-001 and Cyclophosphamide in Treating Young Patients With Relapsed or Refractory Neuroblastoma, Rhabdomyosarcoma, or Rare Tumors With Neuroendocrine Features Completed NCT01048892 Phase 1 cyclophosphamide
7 Continuous Hyperthermic Peritoneal Perfusion (CHPP) With Cisplatin for Children With Peritoneal Cancer Completed NCT00436657 Phase 1 CHPP of Cisplatin
8 Natural History Study of Infants With Adrenal Masses Found on Prenatal and/or Neonatal Imaging Completed NCT00445718
9 Phase II Study of Proton Radiation Therapy for Neuroblastoma Recruiting NCT02112617
10 Molecular Characterization of Neuroblastic Tumor: Correlation With Clinical Outcome Recruiting NCT00588068
11 Prospective Comprehensive Molecular Analysis of Endocrine Neoplasms Recruiting NCT01005654
12 Familial Investigations of Childhood Cancer Predisposition Recruiting NCT03050268
13 131-I-MIBG Therapy for Refractory Neuroblastoma and Metastatic Paraganglioma/Pheochromocytoma Available NCT01163383 131 I-Metaiodobenzylguanidine (131 I-MIBG);131 I-MIBG
14 Expanded Access Protocol Using 131I-MIBG Therapy for Refractory Neuroblastoma, Pheochromocytoma, or Paraganglioma Available NCT01838187
15 Expanded Access Protocol Using I131-MIBG Available NCT01590680

Search NIH Clinical Center for Adrenal Neuroblastoma

Genetic Tests for Adrenal Neuroblastoma

Anatomical Context for Adrenal Neuroblastoma

MalaCards organs/tissues related to Adrenal Neuroblastoma:

39
Adrenal Gland, Liver, Ovary, Lymph Node, Skin

Publications for Adrenal Neuroblastoma

Articles related to Adrenal Neuroblastoma:

(show top 50) (show all 94)
id Title Authors Year
1
Bilateral Cystic Adrenal Neuroblastoma with Cystic Liver metastasis. ( 28163998 )
2017
2
Bilateral adrenal neuroblastoma in the infant: Is it an image-defined risk factor? ( 27285992 )
2016
3
Congenital Adrenal Neuroblastoma With and Without Cystic Change: Differentiating Features With an Emphasis on the of Value of Ultrasound. ( 27556888 )
2016
4
Comparison of Clinical Features and Outcomes in Patients With Bilateral Versus Unilateral Adrenal Neuroblastoma. ( 27820129 )
2016
5
Mass spectrometry of gangliosides in extracranial tumors: Application to adrenal neuroblastoma. ( 27311552 )
2016
6
Adrenal Neuroblastoma in an Adult: Effect of Radiotherapy on Local Progression after Surgical Removal. ( 27547479 )
2016
7
Hemophagocytic Lymphohistiocytosis After Initiation of Chemotherapy for Bilateral Adrenal Neuroblastoma. ( 26583611 )
2016
8
Unusual Differentiation to Pheochromocytoma-Like Cells in an Adrenal Neuroblastoma After Chemotherapy: A Case Report and Literature Review. ( 26207436 )
2015
9
Adrenal neuroblastoma with metastatic mandibular mass: An unusual presentation. ( 26458598 )
2015
10
Concomitant massive hepatic teratoma, hypofibrinogenemia, and adrenal neuroblastoma in an infant: case report. ( 25756389 )
2015
11
(18)F-FDG-PET/CT, (123)I-MIBG and (99m)Tc-MDP whole-body scans, in detecting recurrence of an adult adrenal neuroblastoma. ( 24563879 )
2014
12
Stage 4S Bilateral Adrenal Neuroblastoma in a Newborn. ( 24834390 )
2014
13
Laparoscopic resection of adrenal neuroblastoma without image-defined risk factors: a prospective study on 21 consecutive pediatric patients. ( 24477777 )
2014
14
Clinical outcomes in children with adrenal neuroblastoma undergoing open versus laparoscopic adrenalectomy. ( 23932613 )
2013
15
Combination therapy with gefitinib and doxorubicin inhibits tumor growth in transgenic mice with adrenal neuroblastoma. ( 23930205 )
2013
16
Concurrent adrenal neuroblastoma and kawasaki disease: a report of a rare case. ( 23476867 )
2013
17
Adrenal neuroblastoma in an adult. ( 23575083 )
2013
18
Prenatal diagnosis of adrenal neuroblastoma: a case report with a brief review of the literature. ( 23607014 )
2013
19
Long-term follow-up of the "wait and see" approach to localized perinatal adrenal neuroblastoma. ( 23135423 )
2013
20
Heterochronous bilateral adrenal neuroblastoma: stage 4S in early infancy following resection of stage I lesion in the neonatal period. ( 22009205 )
2012
21
Prenatal diagnosis of atypical adrenal neuroblastoma with pulmonary metastases is possible: Impact on the assessment of prenatal prognosis. ( 22483121 )
2012
22
Hemorrhagic shock due to spontaneous rupture of adrenal neuroblastoma in an infant: a rare case and review of the literature. ( 23018564 )
2012
23
Bilateral hemorrhagic cystic adrenal neuroblastoma with liver and lymph nodal metastases in an infant. ( 23243371 )
2012
24
Sudden death due to adrenal neuroblastoma: child abuse mimic? ( 20857235 )
2011
25
Parotid metastasis from adrenal neuroblastoma. ( 20571790 )
2010
26
Bilateral adrenal neuroblastoma. ( 18951434 )
2009
27
Coexistence of a giant splenic hemangioma and multiple hepatic hemangiomas mimicking a left adrenal neuroblastoma accompanied with multifocal hepatic metastases: pyrite answer. ( 19935098 )
2009
28
Prenatal detection of an extra-adrenal neuroblastoma with hepatic metastases. ( 19643793 )
2009
29
Prenatally detected cystic adrenal neuroblastoma. ( 18279224 )
2008
30
Simultaneous occurrence of right adrenocortical tumor and left adrenal neuroblastoma in an infant with Beckwith-Wiedemann syndrome. ( 18668518 )
2008
31
Case report: an unusual case of adrenal neuroblastoma in pregnancy. ( 18305060 )
2008
32
Bilateral cystic adrenal neuroblastoma with cystic metastasis in the liver. ( 17706480 )
2007
33
Bilateral adrenal neuroblastoma is different. ( 18072022 )
2007
34
Bilateral adrenal neuroblastoma: stage V disease. ( 17805045 )
2007
35
Bilateral adrenal neuroblastoma and nephroblastoma occurring synchronously in a child with Fanconi's anemia and VACTERL syndrome. ( 16410081 )
2006
36
Composite pheochromocytoma associated with adrenal neuroblastoma in an infant: a case report. ( 16481267 )
2006
37
An adult adrenal neuroblastoma: a case report. ( 16438086 )
2005
38
Metastatic adrenal neuroblastoma in an adult. ( 15933424 )
2005
39
A rare case of bilateral stage IV adrenal neuroblastoma with multiple skin metastases in a neonate: diagnosis, management, and outcome. ( 15616928 )
2004
40
Malignant adrenal neuroblastoma in a young dog. ( 15510689 )
2004
41
Rare complication of adrenal neuroblastoma: Budd-Chiari syndrome. ( 14651553 )
2003
42
Adrenal neuroblastoma in an adult: report of a case. ( 14605964 )
2003
43
Maturation of mass-screened localized adrenal neuroblastoma. ( 11685689 )
2001
44
Prenatal sonographic diagnosis of adrenal neuroblastoma. ( 11323782 )
2001
45
Molecular alterations in a case of bilateral adrenal neuroblastoma. ( 11260574 )
2001
46
Paraneoplastic Cushing syndrome due to adrenal neuroblastoma. ( 10696137 )
2000
47
Laparoscopic resection of an adrenal neuroblastoma detected by mass screening that grew in size during the observation period. ( 10854521 )
2000
48
Special imaging casebook. Congenital adrenal neuroblastoma with renovascular hypertension. ( 10685283 )
1999
49
Scrotal hematoma, anemia, and jaundice as manifestations of adrenal neuroblastoma in a newborn. ( 10626873 )
1999
50
Adrenal neuroblastoma in an adult with tumor thrombus in the inferior vena cava. ( 10232523 )
1999

Variations for Adrenal Neuroblastoma

Expression for Adrenal Neuroblastoma

Search GEO for disease gene expression data for Adrenal Neuroblastoma.

Pathways for Adrenal Neuroblastoma

GO Terms for Adrenal Neuroblastoma

Cellular components related to Adrenal Neuroblastoma according to GeneCards Suite gene sharing:

id Name GO ID Score Top Affiliating Genes
1 chromatin GO:0000785 8.62 MYCN SFPQ

Sources for Adrenal Neuroblastoma

3 CDC
7 CNVD
9 Cosmic
10 dbSNP
11 DGIdb
16 ExPASy
18 FMA
28 GO
29 GTR
30 HGMD
31 HMDB
32 HPO
33 ICD10
34 ICD10 via Orphanet
35 ICD9CM
36 IUPHAR
37 KEGG
38 LifeMap
40 MedGen
42 MeSH
43 MESH via Orphanet
44 MGI
46 NCI
47 NCIt
48 NDF-RT
51 NINDS
52 Novoseek
54 OMIM
55 OMIM via Orphanet
59 PubMed
60 QIAGEN
65 SNOMED-CT via HPO
66 SNOMED-CT via Orphanet
67 TGDB
68 Tocris
69 UMLS
70 UMLS via Orphanet
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