MCID: ADR003
MIFTS: 28

Adrenal Neuroblastoma malady

Categories: Cancer diseases, Endocrine diseases, Neuronal diseases

Aliases & Classifications for Adrenal Neuroblastoma

Aliases & Descriptions for Adrenal Neuroblastoma:

Name: Adrenal Neuroblastoma 12 14 69
Neuroblastoma of Adrenal Gland 12

Classifications:



External Ids:

Disease Ontology 12 DOID:5718
NCIt 47 C4827
SNOMED-CT 64 281562007
UMLS 69 C0559460

Summaries for Adrenal Neuroblastoma

Disease Ontology : 12 An adrenal gland cancer that derives from immature neuroblastic cells.

MalaCards based summary : Adrenal Neuroblastoma, also known as neuroblastoma of adrenal gland, is related to neuroblastoma and cerebral cavernous malformations-2. An important gene associated with Adrenal Neuroblastoma is KCNQ1OT1 (KCNQ1 Opposite Strand/Antisense Transcript 1 (Non-Protein Coding)). The drugs Isotretinoin and Tretinoin have been mentioned in the context of this disorder. Affiliated tissues include adrenal gland, liver and skin.

Related Diseases for Adrenal Neuroblastoma

Diseases related to Adrenal Neuroblastoma via text searches within MalaCards or GeneCards Suite gene sharing:

(show all 16)
id Related Disease Score Top Affiliating Genes
1 neuroblastoma 10.6
2 cerebral cavernous malformations-2 10.0 KCNQ1OT1 MYCN
3 hepatitis 9.8
4 pheochromocytoma 9.8
5 budd-chiari syndrome 9.6
6 beckwith-wiedemann syndrome 9.6
7 kawasaki disease 9.6
8 hemangioma 9.6
9 hemophagocytic lymphohistiocytosis 9.6
10 hydronephrosis 9.6
11 megacolon 9.6
12 cushing's syndrome 9.6
13 renovascular hypertension 9.6
14 cervicitis 9.6
15 teratoma 9.6
16 diffuse peritoneal leiomyomatosis 9.1 KCNQ1OT1 KIF1A MYCN QDPR SFPQ

Graphical network of the top 20 diseases related to Adrenal Neuroblastoma:



Diseases related to Adrenal Neuroblastoma

Symptoms & Phenotypes for Adrenal Neuroblastoma

Drugs & Therapeutics for Adrenal Neuroblastoma

Drugs for Adrenal Neuroblastoma (from DrugBank, HMDB, Dgidb, PharmGKB, IUPHAR, NovoSeek, BitterDB):

(show all 38)
id Name Status Phase Clinical Trials Cas Number PubChem Id
1
Isotretinoin Approved Phase 3 4759-48-2 5538 5282379
2
Tretinoin Approved, Investigational, Nutraceutical Phase 3 302-79-4 5538
3 3-Iodobenzylguanidine Phase 3,Phase 2
4 Radiopharmaceuticals Phase 3,Phase 2
5
Oxaliplatin Approved, Investigational Phase 2 61825-94-3 5310940 9887054 6857599, 9887054 43805
6
Octreotide Approved, Investigational Phase 2 83150-76-9 383414 6400441
7
Somatostatin Approved Phase 2 38916-34-6, 51110-01-1 53481605
8
Pertuzumab Approved Phase 2 145040-37-5, 380610-27-5 2540
9 Immunoglobulins Phase 2
10 Antibodies, Monoclonal Phase 2
11 Antibodies Phase 2
12 Gastrointestinal Agents Phase 2
13 Hormone Antagonists Phase 2
14 Hormones Phase 2
15 Hormones, Hormone Substitutes, and Hormone Antagonists Phase 2
16 Edotreotide Phase 2
17 Antineoplastic Agents, Hormonal Phase 2
18
Erlotinib Hydrochloride Phase 2 183319-69-9 176871
19 Protein Kinase Inhibitors Phase 2
20
Cisplatin Approved Phase 1 15663-27-1 84093 441203 2767
21
Cyclophosphamide Approved, Investigational Phase 1 50-18-0, 6055-19-2 2907
22 Alkylating Agents Phase 1
23 Immunosuppressive Agents Phase 1
24 Antirheumatic Agents Phase 1
25 Antineoplastic Agents, Alkylating Phase 1
26
Epinephrine Approved, Vet_approved 51-43-4 5816
27
Dopamine Approved 51-61-6, 62-31-7 681
28 Epinephryl borate
29 Racepinephrine
30
Iodine 7553-56-2 807
31 cadexomer iodine
32 Neurotransmitter Agents
33 Trace Elements
34 Dihydroxyphenylalanine
35 Dopamine Agents
36 Anti-Infective Agents
37 Anti-Infective Agents, Local
38 Micronutrients

Interventional clinical trials:

(show all 17)
id Name Status NCT ID Phase
1 123I-MIBG Scintigraphy in Patients Being Evaluated for Neuroendocrine Tumors Unknown status NCT01373736 Phase 3
2 European Low and Intermediate Risk Neuroblastoma Protocol Recruiting NCT01728155 Phase 3
3 Cixutumumab in Treating Patients With Relapsed or Refractory Solid Tumors Completed NCT00831844 Phase 2
4 Oxaliplatin in Treating Young Patients With Recurrent Solid Tumors That Have Not Responded to Previous Treatment Completed NCT00091182 Phase 2
5 Evaluation of Gallium-68 DOTA-TOC Imaging of Somatostatin Receptor Positive Malignancies Recruiting NCT02177773 Phase 2
6 A Phase II Study of Pertuzumab and Erlotinib for Metastatic or Unresectable Neuroendocrine Tumors Terminated NCT00947167 Phase 2
7 Seneca Valley Virus-001 and Cyclophosphamide in Treating Young Patients With Relapsed or Refractory Neuroblastoma, Rhabdomyosarcoma, or Rare Tumors With Neuroendocrine Features Completed NCT01048892 Phase 1
8 Continuous Hyperthermic Peritoneal Perfusion (CHPP) With Cisplatin for Children With Peritoneal Cancer Completed NCT00436657 Phase 1
9 Natural History Study of Infants With Adrenal Masses Found on Prenatal and/or Neonatal Imaging Completed NCT00445718
10 Phase II Study of Proton Radiation Therapy for Neuroblastoma Recruiting NCT02112617
11 Molecular Characterization of Neuroblastic Tumor: Correlation With Clinical Outcome Recruiting NCT00588068
12 Prospective Comprehensive Molecular Analysis of Endocrine Neoplasms Recruiting NCT01005654
13 Familial Investigations of Childhood Cancer Predisposition Recruiting NCT03050268
14 131-I-MIBG Therapy for Refractory Neuroblastoma and Metastatic Paraganglioma/Pheochromocytoma Available NCT01163383
15 Expanded Access Protocol Using 131I-MIBG Therapy for Refractory Neuroblastoma, Pheochromocytoma, or Paraganglioma Available NCT01838187
16 Expanded Access Protocol Using I131-MIBG Available NCT01590680
17 18F-FDOPA PET in Neuroendocrine Tumours Available NCT02431715

Search NIH Clinical Center for Adrenal Neuroblastoma

Genetic Tests for Adrenal Neuroblastoma

Anatomical Context for Adrenal Neuroblastoma

MalaCards organs/tissues related to Adrenal Neuroblastoma:

39
Adrenal Gland, Liver, Skin, Lymph Node, Ovary

Publications for Adrenal Neuroblastoma

Articles related to Adrenal Neuroblastoma:

(show top 50) (show all 93)
id Title Authors Year
1
Bilateral adrenal neuroblastoma in the infant: Is it an image-defined risk factor? ( 27285992 )
2016
2
Congenital Adrenal Neuroblastoma With and Without Cystic Change: Differentiating Features With an Emphasis on the of Value of Ultrasound. ( 27556888 )
2016
3
Hemophagocytic Lymphohistiocytosis After Initiation of Chemotherapy for Bilateral Adrenal Neuroblastoma. ( 26583611 )
2016
4
Comparison of Clinical Features and Outcomes in Patients With Bilateral Versus Unilateral Adrenal Neuroblastoma. ( 27820129 )
2016
5
Adrenal Neuroblastoma in an Adult: Effect of Radiotherapy on Local Progression after Surgical Removal. ( 27547479 )
2016
6
Mass spectrometry of gangliosides in extracranial tumors: Application to adrenal neuroblastoma. ( 27311552 )
2016
7
Concomitant massive hepatic teratoma, hypofibrinogenemia, and adrenal neuroblastoma in an infant: case report. ( 25756389 )
2015
8
Unusual Differentiation to Pheochromocytoma-Like Cells in an Adrenal Neuroblastoma After Chemotherapy: A Case Report and Literature Review. ( 26207436 )
2015
9
Adrenal neuroblastoma with metastatic mandibular mass: An unusual presentation. ( 26458598 )
2015
10
Laparoscopic resection of adrenal neuroblastoma without image-defined risk factors: a prospective study on 21 consecutive pediatric patients. ( 24477777 )
2014
11
Stage 4S Bilateral Adrenal Neuroblastoma in a Newborn. ( 24834390 )
2014
12
(18)F-FDG-PET/CT, (123)I-MIBG and (99m)Tc-MDP whole-body scans, in detecting recurrence of an adult adrenal neuroblastoma. ( 24563879 )
2014
13
Clinical outcomes in children with adrenal neuroblastoma undergoing open versus laparoscopic adrenalectomy. ( 23932613 )
2013
14
Prenatal diagnosis of adrenal neuroblastoma: a case report with a brief review of the literature. ( 23607014 )
2013
15
Concurrent adrenal neuroblastoma and kawasaki disease: a report of a rare case. ( 23476867 )
2013
16
Long-term follow-up of the "wait and see" approach to localized perinatal adrenal neuroblastoma. ( 23135423 )
2013
17
Combination therapy with gefitinib and doxorubicin inhibits tumor growth in transgenic mice with adrenal neuroblastoma. ( 23930205 )
2013
18
Adrenal neuroblastoma in an adult. ( 23575083 )
2013
19
Bilateral hemorrhagic cystic adrenal neuroblastoma with liver and lymph nodal metastases in an infant. ( 23243371 )
2012
20
Prenatal diagnosis of atypical adrenal neuroblastoma with pulmonary metastases is possible: Impact on the assessment of prenatal prognosis. ( 22483121 )
2012
21
Heterochronous bilateral adrenal neuroblastoma: stage 4S in early infancy following resection of stage I lesion in the neonatal period. ( 22009205 )
2012
22
Hemorrhagic shock due to spontaneous rupture of adrenal neuroblastoma in an infant: a rare case and review of the literature. ( 23018564 )
2012
23
Sudden death due to adrenal neuroblastoma: child abuse mimic? ( 20857235 )
2011
24
Parotid metastasis from adrenal neuroblastoma. ( 20571790 )
2010
25
Prenatal detection of an extra-adrenal neuroblastoma with hepatic metastases. ( 19643793 )
2009
26
Coexistence of a giant splenic hemangioma and multiple hepatic hemangiomas mimicking a left adrenal neuroblastoma accompanied with multifocal hepatic metastases: pyrite answer. ( 19935098 )
2009
27
Bilateral adrenal neuroblastoma. ( 18951434 )
2009
28
Case report: an unusual case of adrenal neuroblastoma in pregnancy. ( 18305060 )
2008
29
Simultaneous occurrence of right adrenocortical tumor and left adrenal neuroblastoma in an infant with Beckwith-Wiedemann syndrome. ( 18668518 )
2008
30
Prenatally detected cystic adrenal neuroblastoma. ( 18279224 )
2008
31
Bilateral adrenal neuroblastoma: stage V disease. ( 17805045 )
2007
32
Bilateral adrenal neuroblastoma is different. ( 18072022 )
2007
33
Bilateral cystic adrenal neuroblastoma with cystic metastasis in the liver. ( 17706480 )
2007
34
Bilateral adrenal neuroblastoma and nephroblastoma occurring synchronously in a child with Fanconi's anemia and VACTERL syndrome. ( 16410081 )
2006
35
Composite pheochromocytoma associated with adrenal neuroblastoma in an infant: a case report. ( 16481267 )
2006
36
An adult adrenal neuroblastoma: a case report. ( 16438086 )
2005
37
Metastatic adrenal neuroblastoma in an adult. ( 15933424 )
2005
38
Malignant adrenal neuroblastoma in a young dog. ( 15510689 )
2004
39
A rare case of bilateral stage IV adrenal neuroblastoma with multiple skin metastases in a neonate: diagnosis, management, and outcome. ( 15616928 )
2004
40
Rare complication of adrenal neuroblastoma: Budd-Chiari syndrome. ( 14651553 )
2003
41
Adrenal neuroblastoma in an adult: report of a case. ( 14605964 )
2003
42
Molecular alterations in a case of bilateral adrenal neuroblastoma. ( 11260574 )
2001
43
Prenatal sonographic diagnosis of adrenal neuroblastoma. ( 11323782 )
2001
44
Maturation of mass-screened localized adrenal neuroblastoma. ( 11685689 )
2001
45
Paraneoplastic Cushing syndrome due to adrenal neuroblastoma. ( 10696137 )
2000
46
Laparoscopic resection of an adrenal neuroblastoma detected by mass screening that grew in size during the observation period. ( 10854521 )
2000
47
Prenatal diagnosis of adrenal neuroblastoma by ultrasound: a report of two cases and review of the literature. ( 10423810 )
1999
48
Adrenal neuroblastoma in an adult with tumor thrombus in the inferior vena cava. ( 10232523 )
1999
49
Scrotal hematoma, anemia, and jaundice as manifestations of adrenal neuroblastoma in a newborn. ( 10626873 )
1999
50
Special imaging casebook. Congenital adrenal neuroblastoma with renovascular hypertension. ( 10685283 )
1999

Variations for Adrenal Neuroblastoma

Expression for Adrenal Neuroblastoma

Search GEO for disease gene expression data for Adrenal Neuroblastoma.

Pathways for Adrenal Neuroblastoma

GO Terms for Adrenal Neuroblastoma

Cellular components related to Adrenal Neuroblastoma according to GeneCards Suite gene sharing:

id Name GO ID Score Top Affiliating Genes
1 chromatin GO:0000785 8.62 MYCN SFPQ

Sources for Adrenal Neuroblastoma

3 CDC
7 CNVD
9 Cosmic
10 dbSNP
11 DGIdb
16 ExPASy
18 FMA
28 GO
29 GTR
30 HGMD
31 HMDB
32 HPO
33 ICD10
34 ICD10 via Orphanet
35 ICD9CM
36 IUPHAR
37 KEGG
38 LifeMap
40 MedGen
42 MeSH
43 MESH via Orphanet
44 MGI
46 NCI
47 NCIt
48 NDF-RT
51 NINDS
52 Novoseek
54 OMIM
55 OMIM via Orphanet
59 PubMed
60 QIAGEN
65 SNOMED-CT via Orphanet
67 TGDB
68 Tocris
69 UMLS
70 UMLS via Orphanet
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