MCID: ADR003
MIFTS: 39

Adrenal Neuroblastoma malady

Cancer diseases, Neuronal diseases, Endocrine diseases categories

Summaries for Adrenal Neuroblastoma

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34MalaCards
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MalaCards: Adrenal Neuroblastoma, also known as neuroblastoma of adrenal gland, is related to neuroblastoma and pheochromocytoma. An important gene associated with Adrenal Neuroblastoma is PHOX2B (paired-like homeobox 2b), and among its related pathways are Transcriptional misregulation in cancer and Neuroscience. The compounds ganglioside and vanillylmandelic acid have been mentioned in the context of this disorder. Affiliated tissues include adrenal gland, liver and lymph node, and related mouse phenotypes are respiratory system and cellular.

Aliases & Classifications for Adrenal Neuroblastoma

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Sources:
9Disease Ontology, 11DISEASES, 63UMLS, 59SNOMED-CT, 41NCIt
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Classifications:

Malacards categories (disease lists): (See all malacards categories)
Global: Cancer diseases
Anatomical: Neuronal diseases, Endocrine diseases


Aliases & Descriptions:

adrenal neuroblastoma 9 11 63
neuroblastoma of adrenal gland 9


External Ids:

Disease Ontology9 DOID:5718
SNOMED-CT59 281562007
NCIt41 C4827

Related Diseases for Adrenal Neuroblastoma

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18GeneCards, 19GeneDecks
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Diseases related to Adrenal Neuroblastoma via text searches within MalaCards or GeneCards/GeneDecks gene sharing:

(show all 42)
idRelated DiseaseScoreTop Affiliating Genes
1neuroblastoma31.4NTRK1, PHOX2B, ENO2, MYCN
2pheochromocytoma30.0NTRK1, MYCN, ENO2
3wilms tumor30.0KCNQ1OT1, ENO2, MYCN
4hepatitis10.2
5autonomic neuropathy10.1NTRK1
6renovascular hypertension10.1
7beckwith-wiedemann syndrome10.1
8fanconi's anemia10.1
9hydronephrosis10.1
10cushing's syndrome10.1
11kawasaki disease10.1
12cervicitis10.1
13hemangioma10.1
14hypertension10.1
15megacolon10.1
16nephroblastoma10.1
17dysgerminoma10.1
18congenital hydronephrosis10.1
19cerebral primitive neuroectodermal tumor10.1ENO2
20hirschsprung's disease10.0PHOX2B, NTRK1
21ganglioglioma10.0NTRK1, ENO2
22olfactory neuroblastoma10.0NTRK1, ENO2
23granular cell tumor10.0ENO2, NTRK1
24embryonal cancer10.0MYCN, NTRK1
25creutzfeldt-jakob disease10.0ENO2, NTRK1
26glioblastoma multiforme10.0NTRK1, MYCN
27alveolar rhabdomyosarcoma10.0ENO2, MYCN
28neuroepithelioma10.0MYCN, ENO2
29brain cancer10.0ENO2, MYCN
30ganglioneuroblastoma10.0ENO2, NTRK1, MYCN
31ganglioneuroma9.9MYCN, ENO2, NTRK1
32thyroid medullary carcinoma9.9MYCN, ENO2, NTRK1
33neuroendocrine tumor9.9ENO2, NTRK1, MYCN
34peripheral primitive neuroectodermal tumor9.9ENO2, NTRK1, MYCN
35rhabdomyosarcoma9.9MYCN, ENO2, NTRK1
36medulloblastoma9.9ENO2, MYCN, NTRK1
37lung small cell carcinoma9.9MYCN, NTRK1, ENO2
38sarcoma9.9ENO2, MYCN, NTRK1
39non-small cell lung carcinoma9.9MYCN, NTRK1, ENO2
40tongue squamous cell carcinoma9.9NTRK1, ENO2, MYCN
41adenocarcinoma9.9ENO2, MYCN, NTRK1
42melanoma9.9MYCN, NTRK1, ENO2

Graphical network of the top 20 diseases related to Adrenal Neuroblastoma:



Diseases related to adrenal neuroblastoma

Symptoms for Adrenal Neuroblastoma

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Drugs & Therapeutics for Adrenal Neuroblastoma

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Sources:
6CenterWatch, 43NIH Clinical Center, 7ClinicalTrials
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Approved drugs:

Search CenterWatch for Adrenal Neuroblastoma

Drug clinical trials:

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Search NIH Clinical Center for Adrenal Neuroblastoma

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Genetic Tests for Adrenal Neuroblastoma

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Anatomical Context for Adrenal Neuroblastoma

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34MalaCards
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MalaCards organs/tissues related to Adrenal Neuroblastoma:

34
Adrenal gland, Liver, Lymph node, Skin, Ovary

Animal Models for Adrenal Neuroblastoma or affiliated genes

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38MGI
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MGI Mouse Phenotypes related to Adrenal Neuroblastoma:

38
idDescriptionMGI Source AccessionScoreTop Affiliating Genes
1MP:00053888.2KCNQ1OT1, MYCN, ENO2, PHOX2B
2MP:00053848.1PHOX2B, ENO2, MYCN, KCNQ1OT1
3MP:00053868.1PHOX2B, ENO2, KIF1A, NTRK1, MYCN
4MP:00028738.1PHOX2B, NTRK1, MYCN, KCNQ1OT1
5MP:00036318.0PHOX2B, ENO2, KIF1A, NTRK1, MYCN
6MP:00053787.6KCNQ1OT1, MYCN, NTRK1, KIF1A, PHOX2B
7MP:00107687.3KCNQ1OT1, MYCN, NTRK1, KIF1A, PHOX2B

Publications for Adrenal Neuroblastoma

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53PubMed
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Articles related to Adrenal Neuroblastoma:

(show top 50)    (show all 81)
idTitleAuthorsYear
1
Prenatal diagnosis of adrenal neuroblastoma: a case report with a brief review of the literature. (23607014)
2013
2
Adrenal neuroblastoma in an adult. (23575083)
2013
3
Clinical outcomes in children with adrenal neuroblastoma undergoing open versus laparoscopic adrenalectomy. (23932613)
2013
4
Hemorrhagic shock due to spontaneous rupture of adrenal neuroblastoma in an infant: a rare case and review of the literature. (23018564)
2012
5
Prenatal diagnosis of atypical adrenal neuroblastoma with pulmonary metastases is possible: Impact on the assessment of prenatal prognosis. (22483121)
2012
6
Bilateral hemorrhagic cystic adrenal neuroblastoma with liver and lymph nodal metastases in an infant. (23243371)
2012
7
Heterochronous bilateral adrenal neuroblastoma: stage 4S in early infancy following resection of stage I lesion in the neonatal period. (22009205)
2012
8
Sudden death due to adrenal neuroblastoma: child abuse mimic? (20857235)
2011
9
Parotid metastasis from adrenal neuroblastoma. (20571790)
2010
10
Coexistence of a giant splenic hemangioma and multiple hepatic hemangiomas mimicking a left adrenal neuroblastoma accompanied with multifocal hepatic metastases: pyrite answer. (19935098)
2009
11
Bilateral adrenal neuroblastoma. (18951434)
2009
12
Prenatally detected cystic adrenal neuroblastoma. (18279224)
2008
13
Simultaneous occurrence of right adrenocortical tumor and left adrenal neuroblastoma in an infant with Beckwith-Wiedemann syndrome. (18668518)
2008
14
Case report: an unusual case of adrenal neuroblastoma in pregnancy. (18305060)
2008
15
Bilateral adrenal neuroblastoma is different. (18072022)
2007
16
Bilateral adrenal neuroblastoma: stage V disease. (17805045)
2007
17
Bilateral adrenal neuroblastoma and nephroblastoma occurring synchronously in a child with Fanconi's anemia and VACTERL syndrome. (16410081)
2006
18
Composite pheochromocytoma associated with adrenal neuroblastoma in an infant: a case report. (16481267)
2006
19
Metastatic adrenal neuroblastoma in an adult. (15933424)
2005
20
A rare case of bilateral stage IV adrenal neuroblastoma with multiple skin metastases in a neonate: diagnosis, management, and outcome. (15616928)
2004
21
Prenatal sonographic diagnosis of adrenal neuroblastoma. (11323782)
2001
22
Molecular alterations in a case of bilateral adrenal neuroblastoma. (11260574)
2001
23
Laparoscopic resection of an adrenal neuroblastoma detected by mass screening that grew in size during the observation period. (10854521)
2000
24
Paraneoplastic Cushing syndrome due to adrenal neuroblastoma. (10696137)
2000
25
Scrotal hematoma, anemia, and jaundice as manifestations of adrenal neuroblastoma in a newborn. (10626873)
1999
26
Laparoscopic resection of mass-screened adrenal neuroblastoma in an 8-month-old infant. (9438636)
1997
27
Delayed presentation of adrenal neuroblastoma. (8732849)
1996
28
Cystic adrenal neuroblastoma: prenatal diagnosis by ultrasonography. (7990758)
1995
29
Special imaging casebook. Neonatal cystic adrenal neuroblastoma with massive hepatomegaly. (7650561)
1995
30
Prenatal diagnosis of metastatic adrenal neuroblastoma with sonography and MR imaging. (8166007)
1994
31
The real-time and color Doppler appearance of adrenal neuroblastoma in a third-trimester fetus. (8159375)
1994
32
An infant with bilateral adrenal neuroblastoma found by mass-screening: report of a case. (8358199)
1993
33
Lymphatic drainage of adrenal neuroblastoma. (7693905)
1993
34
Ten-year survival following resection of an adrenal neuroblastoma with multiple liver metastases. (2102201)
1990
35
The sonographic imaging of fetal adrenal neuroblastoma; a case report. (2653899)
1989
36
Prenatal adrenal neuroblastoma. Case report with review of the literature. (3286884)
1988
37
Antenatal sonographic diagnosis of adrenal neuroblastoma. (2939086)
1986
38
Metachronous bilateral adrenal neuroblastoma. (4027884)
1985
39
Adult adrenal neuroblastoma with extension into inferior vena cava. (6537593)
1984
40
Congenital hydronephrosis with ipsilateral adrenal neuroblastoma: a case report. (682257)
1978
41
Left adrenal neuroblastoma with normal-appearing urogram. (413357)
1977
42
Jaw and pulpal metastasis of an adrenal neuroblastoma. (1060034)
1975
43
The extra-adrenal neuroblastoma: high radiocurability and diagnostic accuracy. (4188902)
1970
44
MATURATION OF CONGENITAL EXTRA-ADRENAL NEUROBLASTOMA. (14048188)
1963
45
Extra-adrenal neuroblastoma. (13715735)
1961
46
Foetal haemic metastasis; an explanation of the pepper-type of metastasis in adrenal neuroblastoma. (13499786)
1957
47
Sympathicoblastoma (adrenal neuroblastoma) with report of a case. (13042085)
1953
48
Adrenal neuroblastoma. (18137543)
1949
49
Dysgerminoma of the ovary in a 4-year-old girl with metastases clinically simulating Wilms' tumor and adrenal neuroblastoma. (18151235)
1949
50
Adrenal neuroblastoma. (20278246)
1947

Variations for Adrenal Neuroblastoma

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Expression for genes affiliated with Adrenal Neuroblastoma

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2BioGPS, 16Gene Expression Omnibus DataSets
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Expression patterns in normal tissues for genes affiliated with Adrenal Neuroblastoma

Search GEO for disease gene expression data for Adrenal Neuroblastoma.

Pathways for genes affiliated with Adrenal Neuroblastoma

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51PathCards, 31KEGG, 5Cell Signaling Technology
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Pathways related to Adrenal Neuroblastoma according to GeneCards/GeneDecks:

idSuper pathways (with members indented)ScoreTop Affiliating Genes
19.4NTRK1, MYCN
28.9ENO2, NTRK1, MYCN

Compounds for genes affiliated with Adrenal Neuroblastoma

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46Novoseek, 25HMDB, 12DrugBank, 30IUPHAR
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Compounds related to Adrenal Neuroblastoma according to GeneCards/GeneDecks:

(show all 16)
idCompoundScoreTop Affiliating Genes
1ganglioside469.7NTRK1, ENO2
2vanillylmandelic acid46 2510.6ENO2, MYCN
3homovanillic acid46 2510.6ENO2, MYCN
4dbc-amp469.5ENO2, MYCN
5choline46 25 1211.4ENO2, NTRK1
6bromodeoxyuridine469.3ENO2, MYCN
7glyceraldehyde 3-phosphate469.3ENO2, MYCN
8catecholamine469.2MYCN, NTRK1, ENO2
9alanine469.2NTRK1, ENO2, PHOX2B
10paraffin469.1MYCN, NTRK1, ENO2
11lactate469.1ENO2, NTRK1, MYCN
12vegf469.0MYCN, NTRK1, ENO2
13nitric oxide46 25 1211.0ENO2, NTRK1, MYCN
14dopamine46 30 25 1211.8PHOX2B, ENO2, NTRK1, MYCN
15tyrosine468.7PHOX2B, ENO2, NTRK1, MYCN
16retinoic acid46 259.6MYCN, NTRK1, ENO2

GO Terms for genes affiliated with Adrenal Neuroblastoma

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17Gene Ontology
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Biological processes related to Adrenal Neuroblastoma according to GeneCards/GeneDecks:

idNameGO IDScoreTop Affiliating Genes
1sympathetic nervous system developmentGO:0484859.6PHOX2B, NTRK1

Products for genes affiliated with Adrenal Neuroblastoma

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Sources for Adrenal Neuroblastoma

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4CDC
14ExPASy
15FMA
23GTR
24HGMD
25HMDB
26ICD10
27ICD10 via Orphanet
28ICD9CM
30IUPHAR
31KEGG
36MeSH
37MESH via Orphanet
38MGI
41NCIt
42NDF-RT
45NINDS
46Novoseek
48OMIM
49OMIM via Orphanet
53PubMed
54QIAGEN
60SNOMED-CT via Orphanet
63UMLS
64UMLS via Orphanet