MCID: ADR003
MIFTS: 36

Adrenal Neuroblastoma malady

Neuronal diseases, Endocrine diseases categories

Summaries for Adrenal Neuroblastoma

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32MalaCards
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MalaCards: Adrenal Neuroblastoma, also known as neuroblastoma of adrenal gland, is related to neuroblastoma and pheochromocytoma. An important gene associated with Adrenal Neuroblastoma is PHOX2B (paired-like homeobox 2b), and among its related pathways is Neuroscience. The compounds vanillylmandelic acid and homovanillic acid have been mentioned in the context of this disorder. Affiliated tissues include adrenal gland, liver and brain, and related mouse phenotypes are nervous system and behavior/neurological.

Aliases & Classifications for Adrenal Neuroblastoma

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Sources:
8Disease Ontology, 10DISEASES, 60UMLS, 39NCIt, 56SNOMED-CT
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Classifications:

Malacards categories (disease lists): (See all malacards categories)
Anatomical: Neuronal diseases, Endocrine diseases


Aliases & Descriptions:

adrenal neuroblastoma 8 10 60
neuroblastoma of adrenal gland 8


External Ids:

Disease Ontology8 DOID:5718
SNOMED-CT56 281562007
NCIt39 C4827

Related Diseases for Adrenal Neuroblastoma

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17GeneCards, 18GeneDecks
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Graphical network of the top 20 diseases related to Adrenal Neuroblastoma:



Diseases related to adrenal neuroblastoma

Clinical Features for Adrenal Neuroblastoma

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Drugs & Therapeutics for Adrenal Neuroblastoma

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5CenterWatch, 41NIH Clinical Center, 6ClinicalTrials
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Approved drugs:

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Drug clinical trials:

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Search NIH Clinical Center for Adrenal Neuroblastoma

Search CenterWatch for Adrenal Neuroblastoma

Genetic Tests for Adrenal Neuroblastoma

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Anatomical Context for Adrenal Neuroblastoma

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32MalaCards
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MalaCards organs/tissues related to Adrenal Neuroblastoma:

32
Adrenal gland, Liver, Brain, Skin, Ovary, Lymph node

Animal Models for Adrenal Neuroblastoma or affiliated genes

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36MGI
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MGI Mouse Phenotypes related to Adrenal Neuroblastoma:

36
idDescriptionMGI Source AccessionScoreTop Affiliating Genes
1MP:00036317.7ENO2, KIF1A, MYCN, NTRK1, PHOX2B
2MP:00053866.9ENO2, SFPQ, PHOX2B, NTRK1, MYCN, KIF1A

Publications for Adrenal Neuroblastoma

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50PubMed
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Articles related to Adrenal Neuroblastoma:

(show top 50)    (show all 94)
idTitleAuthorsYear
1
Concurrent adrenal neuroblastoma and kawasaki disease: a report of a rare case. (23476867)
2013
2
Combination therapy with gefitinib and doxorubicin inhibits tumor growth in transgenic mice with adrenal neuroblastoma. (23930205)
2013
3
Long-term follow-up of the "wait and see" approach to localized perinatal adrenal neuroblastoma. (23135423)
2013
4
Hemorrhagic shock due to spontaneous rupture of adrenal neuroblastoma in an infant: a rare case and review of the literature. (23018564)
2012
5
Bilateral hemorrhagic cystic adrenal neuroblastoma with liver and lymph nodal metastases in an infant. (23243371)
2012
6
Adrenal function in adult long-term survivors of nephroblastoma and neuroblastoma. (22513228)
2012
7
Parotid metastasis from adrenal neuroblastoma. (20571790)
2010
8
Coexistence of a giant splenic hemangioma and multiple hepatic hemangiomas mimicking a left adrenal neuroblastoma accompanied with multifocal hepatic metastases: pyrite answer. (19935098)
2009
9
Bilateral adrenal neuroblastoma. (18951434)
2009
10
Simultaneous occurrence of right adrenocortical tumor and left adrenal neuroblastoma in an infant with Beckwith-Wiedemann syndrome. (18668518)
2008
11
Bilateral adrenal neuroblastoma is different. (18072022)
2007
12
Five patients with congenital adrenal hyperplasia due to 21-hydroxylase deficiency (one with associated neuroblastoma) discovered in three generations of one family. (17057407)
2007
13
An adult adrenal neuroblastoma: a case report. (16438086)
2005
14
Prenatal sonographic diagnosis of adrenal neuroblastoma. (11323782)
2001
15
Maturation of mass-screened localized adrenal neuroblastoma. (11685689)
2001
16
Prenatal diagnosis of adrenal neuroblastoma by ultrasound: a report of two cases and review of the literature. (10423810)
1999
17
Adrenal neuroblastoma in an adult with tumor thrombus in the inferior vena cava. (10232523)
1999
18
Laparoscopic resection of mass-screened adrenal neuroblastoma in an 8-month-old infant. (9438636)
1997
19
Bilateral adrenal neuroblastoma. (9402493)
1997
20
Clinics in diagnostic imaging (31). Adrenal neuroblastoma. (9550915)
1997
21
Cystic adrenal neuroblastoma: prenatal diagnosis by ultrasonography. (7990758)
1995
22
Prenatal diagnosis of metastatic adrenal neuroblastoma with sonography and MR imaging. (8166007)
1994
23
The real-time and color Doppler appearance of adrenal neuroblastoma in a third-trimester fetus. (8159375)
1994
24
Bilateral adrenal neuroblastoma. (8199131)
1994
25
Lymphatic drainage of adrenal neuroblastoma. (7693905)
1993
26
Ultrasonic prenatal diagnosis of liver metastases from adrenal neuroblastoma. (1328312)
1992
27
Ten-year survival following resection of an adrenal neuroblastoma with multiple liver metastases. (2102201)
1990
28
Human neuroblastoma tumor cell lines correspond to the arrested differentiation of chromaffin adrenal medullary neuroblasts. (1982060)
1990
29
Nuclear magnetic resonance tomography in the differential diagnosis of adrenal gland hemorrhage and neuroblastoma in a newborn infant]. (2192272)
1990
30
Prenatal adrenal neuroblastoma. Case report with review of the literature. (3286884)
1988
31
Antenatal sonographic diagnosis of adrenal neuroblastoma. (2939086)
1986
32
Prenatal ultrasonographic diagnosis of fetal adrenal neuroblastoma. (3084577)
1986
33
Metachronous bilateral adrenal neuroblastoma. (4027884)
1985
34
Adult adrenal neuroblastoma with extension into inferior vena cava. (6537593)
1984
35
Bilateral adrenal neuroblastoma. (6711761)
1984
36
Left adrenal neuroblastoma with normal conventional radiologic studies: value of gray scale ultrasonography. (7361156)
1980
37
Congenital hydronephrosis with ipsilateral adrenal neuroblastoma: a case report. (682257)
1978
38
Left adrenal neuroblastoma with normal-appearing urogram. (413357)
1977
39
The extra-adrenal neuroblastoma: high radiocurability and diagnostic accuracy. (4188902)
1970
40
Cushing's syndrome associated with an adrenal neuroblastoma. A case in an infant with clinical, pathological, and adrenal corical and medullary hormone excretion studies. (6024236)
1967
41
Congenital extra-adrenal neuroblastoma. (5976574)
1966
42
MATURATION OF CONGENITAL EXTRA-ADRENAL NEUROBLASTOMA. (14048188)
1963
43
Extra-adrenal neuroblastoma. (13715735)
1961
44
Malignant haemangioendotheliomata simulating miliary tuberculosis and neuroblastoma of the adrenal. (13554454)
1958
45
Foetal haemic metastasis; an explanation of the pepper-type of metastasis in adrenal neuroblastoma. (13499786)
1957
46
Sympathicoblastoma (adrenal neuroblastoma) with report of a case. (13042085)
1953
47
On adrenal neuroblastoma; report of four cases. (14829999)
1951
48
Adrenal neuroblastoma with metastasis to cervical lymph nodes; report of case. (14797819)
1950
49
Dysgerminoma of the ovary in a 4-year-old girl with metastases clinically simulating Wilms' tumor and adrenal neuroblastoma. (18151235)
1949
50
Adrenal neuroblastoma. (20278246)
1947

Genetic Variations for Adrenal Neuroblastoma

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Expression for genes affiliated with Adrenal Neuroblastoma

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1BioGPS, 15Gene Expression Omnibus DataSets
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Expression patterns in normal tissues for genes affiliated with Adrenal Neuroblastoma

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Pathways for genes affiliated with Adrenal Neuroblastoma

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4Cell Signaling Technology
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Pathways related to Adrenal Neuroblastoma according to GeneCards/GeneDecks:

idSuper pathways (with members indented)ScoreTop Affiliating Genes
18.7ENO2, MYCN, NTRK1

Compounds for genes affiliated with Adrenal Neuroblastoma

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44Novoseek, 24HMDB, 11DrugBank, 49PharmGKB, 28IUPHAR
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Compounds related to Adrenal Neuroblastoma according to GeneCards/GeneDecks:

(show all 14)
idCompoundScoreTop Affiliating Genes
1vanillylmandelic acid44 2410.8MYCN, ENO2
2homovanillic acid44 2410.7ENO2, MYCN
3cadmium44 2410.6QDPR, MYCN
4norepinephrine44 11 2411.3ENO2, QDPR, PHOX2B
5dbc-amp449.2MYCN, ENO2
6ganglioside449.0ENO2, NTRK1
7acetylcholine44 49 28 11 2412.9NTRK1, QDPR, ENO2
8paraffin448.8ENO2, MYCN, NTRK1
9cyclic amp44 249.8NTRK1, PHOX2B, SFPQ
10lactate448.7NTRK1, MYCN, ENO2
11alanine448.5PHOX2B, NTRK1, QDPR, ENO2
12catecholamine448.5ENO2, QDPR, MYCN, NTRK1
13dopamine44 28 11 2411.2PHOX2B, NTRK1, MYCN, QDPR, ENO2
14tyrosine448.1PHOX2B, NTRK1, MYCN, QDPR, ENO2

GO Terms for genes affiliated with Adrenal Neuroblastoma

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16Gene Ontology
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Biological processes related to Adrenal Neuroblastoma according to GeneCards/GeneDecks:

idNameGO IDScoreTop Affiliating Genes
1sympathetic nervous system developmentGO:0484859.3NTRK1, PHOX2B

Products for genes affiliated with Adrenal Neuroblastoma

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Sources for Adrenal Neuroblastoma

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3CDC
13ExPASy
14FMA
22GTR
23HGMD
24HMDB
25ICD10
26ICD10 via Orphanet
27ICD9CM
28IUPHAR
29KEGG
34MeSH
35MESH via Orphanet
36MGI
39NCIt
40NDF-RT
43NINDS
44Novoseek
46OMIM
47OMIM via Orphanet
50PubMed
51QIAGEN
57SNOMED-CT via Orphanet
60UMLS
61UMLS via Orphanet