Adrenocortical Tumor malady

Wikipedia: The term adrenal tumor can refer to one of several benign and malignant neoplasms of the adrenal gland,...⁴⁴ more...

MalaCards: Adrenocortical Tumor, also known as tumors of adrenal cortex, is related to tumors of adrenal cortex and carney complex. An important gene associated with Adrenocortical Tumor is PRKAR1A (protein kinase, cAMP-dependent, regulatory, type I, alpha), and among its related pathways are Breast Cancer Regulation by Stathmin1 and Steroid hormone biosynthesis. The drug mitotane and the compounds threonine and h2o2 have been mentioned in the context of this disorder. Affiliated tissues include cortex, adrenal gland and b cells, and related mouse phenotypes are respiratory system and craniofacial.

adrenocortical tumor 7 tumors of adrenal cortex 43

Diseases related to adrenocortical tumor by text searches and GeneDecks gene sharing:

(show top 50)    (show all 751)

id	Related Disease	Score	Top Affiliating Genes
1	tumors of adrenal cortex	31.8	PDE11A, LHCGR, MKI67, MC2R, TP53, CYP11B1
2	carney complex	30.4	BRAF, CDK4, MLANA, FGF2, SYP
3	21-hydroxylase deficiency	29.6	INHA, CYP21A2, SYP
4	beckwith-wiedemann syndrome	28.9	KCNQ1OT1, CDKN1C, IGF2R, IGF2, TP53, CTNNB1
5	nephroblastoma	28.8	CDKN1C, MLANA, IGF2, TP53, CTNNB1, NR5A1
6	virilization	28.4	LHCGR, MC2R, IGF2, IGFBP2, HSD3BP4, TP53
7	cushing's syndrome	28.4	PDE11A, RET, CNC, LHCGR, CHGA, INHA
8	primary pigmented nodular adrenocortical disease	27.6	PDE11A, CNC, CHGA, IGFBP2, GNAS, ESR1
9	adrenal hyperplasia	27.0	PDE11A, CNC, CGB, MC2R, IGFBP3, IGF1
10	paraganglioma	26.8	RET, VHL, SDHB, SDHC, SDHD, CHGB
11	adrenocortical carcinoma	26.8	BRAF, SCARB1, CHGA, MLANA, INHA, FGF2
12	familial adenomatous polyposis	25.6	BRAF, VHL, MYC, AXIN2, CDK4, APC
13	aldosteronism	24.7	VEGFA, LHCGR, SCARB1, CHGA, ATF1, MMP2
14	pheochromocytoma	23.8	RET, VHL, VEGFA, MYC, SDHB, SDHC
15	polyposis	19.7	RET, BUB1B, BRAF, VHL, VEGFA, MYC
16	neuroblastoma	19.0	RET, VHL, VEGFA, MYC, SDHB, SDHD
17	cholesterol	17.6	VEGFA, MYC, SDHB, SDHC, LHCGR, SCARB1
18	sarcoma	15.5	RET, BRAF, VEGFA, MYC, SDHB, SDHC
19	adenoma	14.3	PDE11A, RET, CNC, BRAF, VHL, VEGFA
20	gestational trophoblastic neoplasm	14.0	CGB, CGB7, CDKN1C, INHA, IGF2, H19
21	46,xy disorder of sex development and 46,xy complete gonadal dysgenesis	14.0	NR0B1, NR5A1, WNT4
22	adrenal rest tumor	14.0	CGB, CYP21A2, NR5A1
23	endodermal sinus tumor	13.9	CGB, INHA, GATA6, GATA4
24	46, xy disorders of sex development	13.9	SRD5A1, NR0B1, NR5A1, WNT4
25	male pseudohermaphroditism due to defective lh	13.9	LHCGR, HSD3BP4, CYP17A1, SRD5A1, NR0B1, NR5A1
26	lipoid congenital adrenal hyperplasia	13.9	CYP11A1, NR5A1, STAR
27	pleomorphic liposarcoma	13.9	INHA, CALB2, DLGAP5
28	3-beta-hydroxysteroid dehydrogenase deficiency	13.9	HSD3BP4, CYP17A1, CYP21A2
29	x-linked adrenal hypoplasia congenita	13.9	NR0B1, NR5A1, STAR
30	disorders of sex development	13.9	CYP21A2, SRD5A1, NR0B1, NR5A1, WNT4
31	xy sex reversal	13.9	CYP11A1, NR0B1, NR5A1, STAR
32	swyer syndrome	13.9	CGB, NR0B1, NR5A1
33	smith-lemli-opitz syndrome	13.9	CGB7, HSD3BP4, CYP11A1, SRD5A1, STAR
34	paraganglioma and gastric stromal sarcoma	13.9	SDHB, SDHC, SDHD
35	familial glucocorticoid deficiency	13.9	MC2R, NR0B1, STAR, POMC
36	gonadal dysgenesis	13.9	CGB, HSD3BP4, CYP21A2, SRD5A1, NR0B1, NR5A1
37	gastric small cell carcinoma	13.9	CHGA, ENO2, SYP
38	supratentorial neoplasm	13.8	CHGA, ENO2, SYP
39	precocious puberty, male	13.8	LHCGR, CYP19A1, CYP21A2
40	hereditary paraganglioma-pheochromocytoma syndromes	13.8	SDHB, SDHC, SDHD
41	11-beta-hydroxylase deficiency	13.8	CYP11B2, CYP11B1, CYP21A2
42	androgen insensitivity syndrome	13.8	INHA, IGF2, IGFBP2, CYP19A1, SRD5A1, NR5A1
43	late-onset congenital adrenal hyperplasia	13.8	HSD3BP4, CYP21A2, POMC
44	lipoid adrenal hyperplasia	13.8	CYP11A1, NR0B1, STAR, POMC
45	mitochondrial complex ii deficiency	13.8	SDHB, SDHC, SDHD
46	carotid body tumor	13.8	SDHB, SDHC, SDHD
47	neuroendocrine carcinoma	13.8	CHGA, MEN1, ENO2, SYP, HDC
48	glucocorticoid deficiency	13.8	MC2R, CYP17A1, NR0B1, STAR, POMC
49	testicular leydig cell tumor	13.8	CGB, CYP19A1, CYP21A2
50	adrenocortical insufficiency	13.8	CYP21A2, NR5A1, STAR, POMC

Approved drugs:

Drug clinical trials:

Inferred drug relations via UMLS/NDF-RT:

^43 28 mitotane

MalaCards organs/tissues related to adrenocortical tumor:

²²

MGI Mouse Phenotypes related to adrenocortical tumor:

²⁵ (show all 28)

id	Description	MGI Source Accession	Score	Top Affiliating Genes
1	respiratory system phenotype	MP:0005388	10.1	GATA6, PRKAR1A, NF1, CREM, CD14, KCNQ1OT1
2	craniofacial phenotype	MP:0005382	9.6	H19, PRKAR1A, PDGFRA, NF1, NOV, GNAS
3	endocrine/exocrine gland phenotype	MP:0005379	9.5	PRKAR1A, STAR, NF1, NR5A1, CYP11B1, CYP1A2
4	hematopoietic system phenotype	MP:0005397	8.9	FGF2, INHA, CDK4, VHL, BRAF, BUB1B
5	liver/biliary system phenotype	MP:0005370	8.7	PRLH, TLR4, ACADVL, NF1, CREM, CYP19A1
6	reproductive system phenotype	MP:0005389	8.2	NR5A1, NR0B1, SRD5A1, CYP11B1, CYP11A1, DLGAP5
7	immune system phenotype	MP:0005387	7.9	ADM, WNT4, POMC, PRKAR1A, THBS1, TLR4
8	limbs/digits/tail phenotype	MP:0005371	7.9	H19, CDKN1C, AXIN2, VEGFA, VHL, RET
9	pigmentation phenotype	MP:0001186	7.7	NF1, PDGFRA, TLR4, PRKAR1A, PRKAR2B, POMC
10	embryogenesis phenotype	MP:0005380	7.5	AURKA, AXIN2, SCARB1, KCNQ1OT1, SDHD, MYC
11	renal/urinary system phenotype	MP:0005367	7.3	NF1, NOV, CTNNB1, CYP11B1, CYP11B2, PTHLH
12	hearing/vestibular/ear phenotype	MP:0005377	7.3	CTNNB1, PPARG, NR2F1, CRHR2, NF1, CYP19A1
13	integument phenotype	MP:0010771	7.0	PRKAR2B, PRLHR, TLR4, PDGFRA, NF1, CTNNB1
14	digestive/alimentary phenotype	MP:0005381	6.6	TERT, GHSR, GHRL, ESR2, ESR1, GLI1
15	nervous system phenotype	MP:0003631	6.4	GATA4, H19, HDC, WNT4, PTHLH, TERT
16	no phenotypic analysis	MP:0003012	6.3	CTNNB1, CYP1A2, TP53, GHSR, PPARG, NR2F1
17	vision/eye phenotype	MP:0005391	6.2	NR2F1, PPARG, CTNNB1, PTHLH, TP53, CRHR2
18	normal phenotype	MP:0002873	6.0	CYP11A1, TERT, GHRL, ESR2, HRAS, GLI1
19	mortality/aging	MP:0010768	5.8	NES, PRKAR1A, STAR, TLR4, ACADVL, PDGFRA
20	adipose tissue phenotype	MP:0005375	5.7	HDC, POMC, PRKAR2B, PRLH, PRLHR, PRKAR1A
21	growth/size phenotype	MP:0005378	5.7	CREB1, HTR4, IGF2R, CCNE1, APC, MDM2
22	behavior/neurological phenotype	MP:0005386	5.1	CYP17A1, IGF2, CCND2, CCNE1, ENO2, MC2R
23	skeleton phenotype	MP:0005390	4.0	CDKN2A, CD14, AXIN2, MTOR, MYC, VEGFA
24	tumorigenesis	MP:0002006	3.9	TERT, MMP2, CDK4, CDKN2A, CDK2, AURKA
25	muscle phenotype	MP:0005369	2.8	PGR, PRKAR1A, THBS1, TLR4, ACADVL, PDGFRA
26	cardiovascular system phenotype	MP:0005385	2.7	IGF2R, CHGA, SCARB1, SDHD, MYC, VEGFA
27	cellular phenotype	MP:0005384	2.1	PTHLH, ENO2, APC, MDM2, MEN1, FGF2
28	homeostasis/metabolism phenotype	MP:0005376	1.1	NR0B1, GIPR, ESR2, ESR1, AKR1B1, HRAS

Articles related to adrenocortical tumor:

(show top 50)    (show all 103)

id	Title	Authors	Year	Affiliating Genes
1	Inherited germline TP53 mutation encodes a protein wi th an aberrant C-terminal motif in a case of pediatric adrenocortical tumor. (20967502)	Pinto E.M.... Zambetti G.P.	2011	TP53
2	Steroidogenic factor 1 overexpression and gene amplif ication are more frequent in adrenocortical tumors from children than from adul ts. (20080844)	Almeida M.Q.... Latronico A.C.	2010	NR5A1
3	Regulation of insulin-like growth factor-mammalian ta rget of rapamycin signaling by microRNA in childhood adrenocortical tumors. (20484036)	Doghman M.... Lalli E.	2010	MTOR
4	Abrogation of TLR4 and CD14 expression and signaling in human adrenocortical tumors. (20826579)	Kanczkowski W.... Bornstein S.R.	2010	TLR4, CD14
5	Increased ratio of mRNA expression of the genes CYP17 and CYP11B1 indicates autonomous cortisol production in adrenocortical tumors. (19564722)	Enberg U.... ThorAcn M.	2009	CYP17A1, CYP11B1
6	Differences in the expression of histamine-related ge nes and proteins in normal human adrenal cortex and adrenocortical tumors. (19568768)	SzabA^ P.M.... Igaz P.	2009	HDC
7	Aromatase expression in the normal human adult adrenal and in adrenocortical tumors: biochemical, immunohistochemical, and molecular studies. (18974231)	Moreau F.... Reznik Y.	2009	CYP19A1
8	Expression profiles of the glucose-dependent insulinotropic peptide receptor and LHCGR in sporadic adrenocortical tumors. (18971217)	Costa M.H.... Fragoso M.C.	2009	LHCGR, GIPR
9	Wnt/beta-catenin and 3',5'-cyclic adenosine 5'-monophosphate/protein kinase A signaling pathways alterations and somatic beta-catenin gene mutations in the progression of adrenocortical tumors. (18647815)	Gaujoux S.... Bertherat J.	2008	CTNNB1, PRKAR1A
10	Comparison of immunohistochemical markers in the differential diagnosis of adrenocortical tumors: immunohistochemical analysis of adrenocortical tumors. (18091323)	Zhang H.... Zhang Z.	2008	INHA, CALB2, MLANA
11	Expression of insulin-like growth factor-II and its receptor in pediatric and adult adrenocortical tumors. (18611974)	Almeida M.Q.... Latronico A.C.	2008	IGF2, IGF2R
12	High frequency of loss of heterozygosity at 11p15 and IGF2 overexpression are not related to clinical outcome in childhood adrenocortical tumors positive for the R337H TP53 mutation. (18786438)	Rosati R.... Lalli E.	2008	IGF2
13	Simultaneous occurrence of right adrenocortical tumor and left adrenal neuroblastoma in an infant with Beckwith-Wiedemann syndrome. (18668518)	Alsultan A.... Garrington T.P.	2008	KCNQ1OT1
14	Sporadic adrenocortical tumors: genetics and perspec tives for the pathologist (19068395)	Tissier F.	2008	CTNNB1
15	Identification of a clinically homogenous subgroup of benign cortisol-secreting adrenocortical tumors characterized by alterations of the protein kinase A (PKA) subunits and high PKA activity. (18505904)	Vincent-Dejean C.... Bertherat J.	2008	PRKAR1A, PRKAR2B
16	Nephroblastoma overexpressed/cysteine-rich protein 61/connective tissue growth factor/nephroblastoma overexpressed gene-3 (NOV/CCN3), a selective adrenocortical cell proapoptotic factor, is down-regulated in childhood adrenocortical tumors. (17566092)	Doghman M.... Lalli E.	2007	NR5A1, NOV
17	Analysis by cDNA microarrays of gene expression patterns of human adrenocortical tumors. (16556722)	Slater E.P.... Bartsch D.K.	2006	IGF2, CHGB
18	Mechanisms of disease: adrenocortical tumors--molecular advances and clinical perspectives. (17082810)	Bertherat J.... Bertagna X.	2006	APC, MC2R
19	Adrenocortical tumors and hyperplasias in childhood--etiology, genetics, clinical presentation and therapy. (17021581)	Sutter J.A.... Grimberg A.	2006	GNAS, PRKAR1A
20	Loss of growth hormone secretagogue receptor 1a and overexpression of type 1b receptor transcripts in human adrenocortical tumors. (16020971)	Barzon L.... Palu G.	2005	GHSR, GHRL
21	Transcription factors GATA-6, SF-1, and cell proliferation in human adrenocortical tumors. (15767045)	Kiiveri S.... Heikinheimo M.	2005	NR5A1, GATA6
22	Nestin expression in normal adrenal gland and adrenocortical tumors. (16136494)	Toti P.... Bertelli E.	2005	NES
23	Mutational analysis of PRKAR1A and Gs(alpha) in sporadic adrenocortical tumors. (15926108)	Libe R.... Spada A.	2005	GNAS, PRKAR1A
24	Mutations of beta-catenin in adrenocortical tumors: activation of the Wnt signaling pathway is a frequent event in both benign and malignant adrenocortical tumors. (16140927)	Tissier F.... Bertherat J.	2005	CTNNB1
25	The adrenocortical tumor cell line NCI-H295R as an in vitro screening system for the evaluation of CYP11B2 (aldosterone synthase) and CYP11B1 (steroid-11beta-hydroxylase) inhibitors. (15985365)	Muller-Vieira U.... Hartmann R.W.	2005	CYP19A1, CYP11B1, CYP11B2
26	Plasma chromogranin A in incidental non-functioning, benign, solid adrenocortical tumors. (15296477)	Bernini G.... Salvetti A.	2004	CHGA
27	Diagnostic value of A103 and inhibin-alpha in adrenocortical tumors: an immunohistochemical study using tissue microarray techniques (15256108)	Zhang H.Y.... Zhang Y.H.	2004	INHA
28	Distinct transcriptional profiles of adrenocortical tumors uncovered by DNA microarray analysis. (12547710)	Giordano T.J.... Hanash S.M.	2003	AURKA
29	Adrenocortical tumors with neuroendocrine differentiation (12575533)	Kazantseva I.A.... Smirnov V.B.	2002	SYP, CHGA
30	Genetics of adrenocortical tumors: Carney complex. (11353891)	Stratakis C.A.	2001	CNC
31	An inherited mutation outside the highly conserved DNA-binding domain of the p53 tumor suppressor protein in children and adults with sporadic adrenocortical tumors. (11600572)	Latronico A.C.... Mendonca B.B.	2001	TP53
32	Significantly increased cortisol secretion in normal adrenocortical cells transfected with K-ras mutants derived from human functional adrenocortical tumors. (11403720)	Hsu C.H.... Lin S.R.	2001	HRAS, CYP17A1, CYP11A1
33	Fibroblast growth factor-2 inhibits the maturation of pro-insulin-like growth factor-II (Pro-IGF-II) and the expression of insulin-like growth factor binding protein-2 (IGFBP-2) in the human adrenocortical tumor cell line NCI-H295R. (10965883)	Boulle N.... Le Bouc Y.	2000	FGF2, IGFBP2
34	Pediatric adrenocortical tumors: molecular events leading to insulin-like growth factor II gene overexpression. (10843195)	Wilkin F.... Deal C.	2000	TP53, IGF2, H19
35	High expression of cyclin E and G1 CDK and loss of function of p57KIP2 are involved in proliferation of malignant sporadic adrenocortical tumors. (10634406)	Bourcigaux N.... Gicquel C.	2000	CDK4, CDK2, IGF2
36	Mechanisms of epigenetic silencing of the c21 gene in Y1 adrenocortical tumor cells. (11196471)	Szyf M.... Slack A.D.	2000	TAP2
37	Expression of the angiogenesis markers vascular endothelial growth factor-A, thrombospondin-1, and platelet-derived endothelial cell growth factor in human sporadic adrenocortical tumors: correlation with genotypic alterations. (11134136)	de Fraipont F.... Feige J.J.	2000	VEGFA, IGF2, THBS1
38	Adrenocortical tumors: recent advances in basic concepts and clinical management. (10357696)	Bornstein S.R.... Chrousos G.P.	1999	TP53, IGF2, MEN1
39	Adrenocortical tumor in a patient with familial adenomatous polyposis: a case associated with a complete inactivating mutation of the APC gene and unusual histological features. (9496836)	Wakatsuki S.... Horii A.	1998	NR5A1
40	Mutations in adrenocortical tumors. (9694578)	Reincke M.	1998	TP53, IGF2
41	Expression of insulin-like growth factor binding protein 1-6 genes in adrenocortical tumors and pheochromocytomas. (9851669)	IlvesmAoki V.... Voutilainen R.	1998	IGFBP2, IGFBP1
42	Increased levels of insulin-like growth factor II (IGF-II) and IGF-binding protein-2 are associated with malignancy in sporadic adrenocortical tumors. (9589681)	Boulle N.... Le Bouc Y.	1998	IGFBP3, IGF2, IGFBP2
43	Aminoglutethimide suppresses adrenocorticotropin receptor expression in the NCI-h295 adrenocortical tumor cell line. (9795339)	Fassnacht M.... Reincke M.	1998	MC2R
44	ACTH receptor mRNA in human adrenocortical tumors: overexpression in aldosteronomas. (9888585)	Arnaldi G.... Mantero F.	1998	MC2R
45	Expression of inhibin alpha in the human adrenal gland and adrenocortical tumors. (9888589)	Arola J.... Kahri A.	1998	INHA
46	Deletion of the adrenocorticotropin receptor gene in human adrenocortical tumors: implications for tumorigenesis. (9284742)	Reincke M.... Allolio B.	1997	MC2R
47	Structural and functional abnormalities at 11p15 are associated with the malignant phenotype in sporadic adrenocortical tumors: study on a series of 82 tumors. (9253334)	Gicquel C.... Le Bouc Y.	1997	IGF2, H19
48	Neuroendocrine differentiation of adrenocortical tumors. (7828138)	Haak H.R.... Fleuren G.J.	1995	ENO2, SYP
49	Cushing's syndrome induced by hypersecretion of cortisol from only one of bilateral adrenocortical tumors. (1542264)	Kato S.... Ohtani S.	1992	POMC
50	Small adrenocortical tumors without apparent clinical endocrine abnormalities. Immunolocalization of steroidogenic enzymes. (1448379)	Suzuki T.... Nagura H.	1992	CYP11A1, HSD3BP4

Genes related to adrenocortical tumor according to GeneCards:

(show top 50)    (show all 105)

id	Symbol	Description	Score	GeneCards Section Context
1	PRKAR1A	protein kinase, cAMP-dependent, regulatory, type I, alpha	11.0	Publications
2	KCNQ1OT1	KCNQ1 opposite strand/antisense transcript 1 (non-protein coding)	11.0	Publications
3	PRLH	prolactin releasing hormone	11.0	Publications
4	CNC	Carney complex, multiple neoplasia and lentiginosis	11.0	Publications
5	PRLHR	prolactin releasing hormone receptor	11.0	Publications
6	NR5A1	nuclear receptor subfamily 5, group A, member 1	11.0	Publications
7	NR0B1	nuclear receptor subfamily 0, group B, member 1	11.0	Publications
8	NOV	nephroblastoma overexpressed	11.0	Publications
9	NR2F1	nuclear receptor subfamily 2, group F, member 1	11.0	Publications
10	DLGAP5	discs, large (Drosophila) homolog-associated protein 5	11.0	Publications
11	MC2R	melanocortin 2 receptor (adrenocorticotropic hormone)	11.0	Publications
12	H2BFS	H2B histone family, member S (pseudogene)	11.0	Publications
13	H19	H19, imprinted maternally expressed transcript (non-protein coding)	11.0	Publications
14	INHA	inhibin, alpha	11.0	Expressions, Publications
15	LHCGR	luteinizing hormone/choriogonadotropin receptor	11.0	Publications
16	IGFBP2	insulin-like growth factor binding protein 2, 36kDa	11.0	Publications
17	GIPR	gastric inhibitory polypeptide receptor	11.0	Publications
18	CHGB	chromogranin B (secretogranin 1)	11.0	Publications
19	HSD3BP4	hydroxy-delta-5-steroid dehydrogenase, 3 beta, pseudogene 4	11.0	Publications
20	MLANA	melan-A	11.0	Publications
21	GATA6	GATA binding protein 6	11.0	Publications
22	ALOX15B	arachidonate 15-lipoxygenase, type B	11.0	Publications
23	CCNG1	cyclin G1	11.0	Publications
24	CGB7	chorionic gonadotropin, beta polypeptide 7	11.0	Publications
25	CYP11B1	cytochrome P450, family 11, subfamily B, polypeptide 1	11.0	Publications
26	PINK1	PTEN induced putative kinase 1	11.0	Publications
27	HDC	histidine decarboxylase	11.0	Publications
28	NES	nestin	11.0	Publications
29	SDHD	succinate dehydrogenase complex, subunit D, integral membrane protein	11.0	Publications
30	WNT4	wingless-type MMTV integration site family, member 4	11.0	Publications
31	SYP	synaptophysin	11.0	Publications
32	PRKAR2B	protein kinase, cAMP-dependent, regulatory, type II, beta	11.0	Publications
33	ACADVL	acyl-CoA dehydrogenase, very long chain	11.0	Publications
34	AXIN2	axin 2	11.0	Publications
35	GTF3A	general transcription factor IIIA	11.0	Publications
36	MEN1	multiple endocrine neoplasia I	11.0	Publications
37	IGF2	insulin-like growth factor 2 (somatomedin A)	11.0	Publications
38	CDKN1C	cyclin-dependent kinase inhibitor 1C (p57, Kip2)	11.0	Publications
39	CYP11A1	cytochrome P450, family 11, subfamily A, polypeptide 1	11.0	Publications
40	STAR	steroidogenic acute regulatory protein	11.0	Publications
41	GLI1	GLI family zinc finger 1	11.0	Publications
42	ATF1	activating transcription factor 1	11.0	Publications
43	TAP2	transporter 2, ATP-binding cassette, sub-family B (MDR/TAP)	11.0	Publications
44	CREM	cAMP responsive element modulator	11.0	Publications
45	CHGA	chromogranin A (parathyroid secretory protein 1)	11.0	Publications
46	SDHC	succinate dehydrogenase complex, subunit C, integral membrane protein, 15kDa	11.0	Publications
47	CYP17A1	cytochrome P450, family 17, subfamily A, polypeptide 1	11.0	Publications
48	CRHR2	corticotropin releasing hormone receptor 2	11.0	Publications
49	CGB	chorionic gonadotropin, beta polypeptide	11.0	Publications
50	CYP21A2	cytochrome P450, family 21, subfamily A, polypeptide 2	11.0	Publications

Pathways related to adrenocortical tumor according to GeneDecks:

(show top 50)    (show all 108)

id	Pathway	Score	Top Affiliating Genes
1	Breast Cancer Regulation by Stathmin136	10.6	CCNE1, FGF2, CCNG1
2	Steroid hormone biosynthesis20	10.4	CYP17A1, CYP11A1, CYP11B2, SRD5A1, CYP11B1, CYP21A2
3	Transcription CREM signaling in testis10	10.2	CREB1, PRKAR2B, PRKAR1A, CREM, GNAS
4	GADD45 Pathway36	10.2	CCND2, CDK2, CDK4, CCNE1, TP53, CCNG1
5	Beta-2 adrenergic-dependent CFTR expression41	10.2	CREB1, PRKAR1A, GNAS, ATF1, PRKAR2B
6	Transcription_CREM signaling in testis41	10.2	PRKAR2B, PRKAR1A, GNAS, CREB1, CREM
7	Development_Hedgehog and PTH signaling pathways in bone and cartilage development41	10.1	GNAS, CREB1, PRKAR1A, PRKAR2B, PTHLH, GLI1
8	Development Hedgehog and PTH signaling pathways in bone and cartilage development10	10.1	GLI1, PTHLH, CREB1, PRKAR1A, PRKAR2B, GNAS
9	Metabolism of lipids and lipoproteins38	10.0	CYP17A1, CYP11B1, SCARB1, AKR1B1, CYP11B2, STAR
10	Development_A2B receptor- action via G-protein alpha s41	10.0	BRAF, GNAS, HRAS, PRKAR1A, CREB1, PRKAR2B
11	Basal cell carcinoma20	9.9	APC, GLI1, TP53, CTNNB1, WNT4, AXIN2
12	G1-S Phase Transition36	9.8	CCND2, CDK2, CDKN2A, TP53, CCNE1, CDK4
13	Development Role of Activin A in cell differentiation and proliferation10	9.8	GNAS, NR5A1, PRKAR2B, PRKAR1A, CREB1, LHCGR
14	Development A2B receptor- action via G-protein alpha s10	9.8	PRKAR1A, CREB1, CTNNB1, HRAS, GNAS, BRAF
15	Development_Role of Activin A in cell differentiation and proliferation41	9.8	CREB1, GNAS, LHCGR, MYC, CYP11A1, NR5A1
16	Development Ligand-independent activation of ESR1 and ESR210	9.7	HRAS, HTR4, PRKAR2B, GNAS, PRKAR1A, ESR2
17	DNA damage ATM/ATR regulation of G1/S checkpoint10	9.7	CCND2, CCNE1, CDK4, CDK2, MYC, MDM2
18	Transcription P53 signaling pathway10	9.7	TP53, CDKN2A, CDK2, VEGFA
19	Transcription PPAR Pathway10	9.6	PRKAR1A, PDGFRA, PPARG, HRAS, PRKAR2B
20	Transcription_PPAR Pathway41	9.5	HRAS, PRKAR1A, PDGFRA, PPARG, PRKAR2B
21	DNA damage_ATM/ATR regulation of G1/S checkpoint41	9.5	CDK2, MYC, TP53, CCND2, CCNE1, MDM2
22	Cell Cycle / Checkpoint Control3	9.4	BUB1B, AURKA, CDK2, TP53, CCND2, CCNE1
23	Endometrial cancer20	9.4	MYC, TP53, HRAS, APC, BRAF, CTNNB1
24	Development_Ligand-independent activation of ESR1 and ESR241	9.3	ESR1, HRAS, PRKAR1A, GNAS, HTR4, PRKAR2B
25	Signal transduction PTEN pathway10	9.2	CTNNB1, MTOR, MDM2, HRAS, IGF1, TP53
26	Glioblastoma Multiforme36	9.2	APC, MDM2, CCNE1, IGF2, HRAS, TP53
27	Development IGF-RI signaling10	9.1	IGF1, IGFBP1, HRAS, IGFBP3, IGFBP2, IGF2
28	Estrogen-mediated S-Phase Entry36	9.1	CCNE1, ESR2, CDK4, CDK2, ESR1, MYC
29	Cell cycle20	9.0	CDKN2A, MYC, CDK2, BUB1B, TP53, CCND2
30	Transcription_P53 signaling pathway41	9.0	CDKN2A, MMP2, MDM2, VEGFA, CDK2, TP53
31	Chronic myeloid leukemia20	9.0	BRAF, MYC, MDM2, CDKN2A, TP53, CDK4
32	p53 signaling pathway20	9.0	CCND2, CDK2, CDK4, TP53, IGF1, CDKN2A
33	Colorectal Cancer Metastasis36	9.0	AXIN2, CTNNB1, PRKAR1A, PRKAR2B, WNT4, APC
34	Nanog in Mammalian ESC Pluripotency36	9.0	HRAS, BRAF, PDGFRA, CTNNB1, IGF1, IGF2
35	P2Y Receptor Signaling36	8.9	FGF2, BRAF, PRKAR2B, MYC, PRKAR1A, HRAS
36	Melanoma20	8.9	BRAF, CDKN2A, HRAS, CDK4, FGF2, PDGFRA
37	Glioma20	8.8	PDGFRA, MTOR, BRAF, CDKN2A, CDK4, TP53
38	Development_IGF-1 receptor signaling41	8.8	MTOR, IGFBP1, IGF2, IGFBP2, IGFBP3, IGF1
39	cAMP Pathway36	8.7	PRKAR2B, IGF2, HRAS, CREM, IGF2R, PDGFRA
40	Thyroid cancer20	8.7	TP53, CTNNB1, HRAS, MYC, BRAF, RET
41	Prostate cancer20	8.7	PDGFRA, CREB1, MTOR, CDK2, MDM2, CCNE1
42	Estrogen Pathway36	8.6	ESR1, FGF2, PRKAR2B, IGF2, IGF1, HRAS
43	PPAR Pathway36	8.6	FGF2, PDGFRA, IGF2, PPARG, IGF1, PRKAR2B
44	ERK Signaling36	8.5	CREB1, ESR2, ESR1, HRAS, IGF2, ATF1
45	Pancreatic Adenocarcinoma36	8.4	CDK4, CCNE1, CDK2, MMP2, CDKN2A, FGF2
46	MAPK Signaling36	8.4	IGF2, IGF1, TP53, CREB1, PRKAR1A, IGF2R
47	Bladder cancer20	8.3	MDM2, BRAF, VEGFA, MYC, CDKN2A, MMP2
48	Molecular Mechanisms of Cancer36	8.3	APC, MDM2, FGF2, CDK4, CDK2, CCNE1
49	Pathways in cancer20	8.0	MTOR, AXIN2, CDK4, MMP2, FGF2, MDM2
50	TGF-beta Signaling Pathways37	7.9	PPARG, CREB1, ESR2, ESR1, MYC, ATF1

Compounds related to adrenocortical tumor according to GeneDecks:

(show top 50)    (show all 321)

id	Compound	Score	Top Affiliating Genes
1	threonine32	10.2	PINK1, RET, LHCGR, AXIN2, CCNG1, IGFBP1
2	h2o232	9.7	SDHB, CCNG1, HSD3BP4, AKR1B1, ESR2, CREB1
3	progestin32	9.6	VEGFA, LHCGR, CDK4, IGFBP1, IGF2, IGFBP2
4	glucose32	9.5	BRAF, VHL, CGB, ATF1, CDK4, MKI67
5	3beta-hydroxysteroid32	9.3	LHCGR, INHA, MC2R, IGF2, HSD3BP4, ESR2
6	ly29400232	9.3	RET, VHL, VEGFA, MMP2, FGF2, HRAS
7	dhea32	8.9	MC2R, IGFBP1, IGF2, IGFBP2, IGFBP3, IGF1
8	hydrocortisone32 9 9	10.6	CD14, MMP2, FGF2, MC2R, IGFBP1, IGF2
9	rapamycin32 42	9.5	BRAF, VHL, VEGFA, MTOR, CDK2, CDK4
10	calcitriol32 42 9 18 9	12.4	MYC, CDK2, CD14, CDK4, FGF2, IGFBP1
11	gnrh32	8.4	LHCGR, CGB, CGB7, MKI67, INHA, IGFBP1
12	12-o-tetradecanoylphorbol 13-acetate32	8.4	RET, BRAF, MYC, ATF1, CDK4, MMP2
13	mifepristone32 42 9 9	11.3	CGB, CDK2, MKI67, HSD3BP4, ESR1, ESR2
14	17beta-hydroxysteroid32	8.3	MKI67, HSD3BP4, ESR1, ESR2, CYP11B2, CYP11A1
15	oxygen32 18	9.3	SDHB, SDHC, SDHD, SCARB1, CDK2, CDKN2A
16	pge232	8.3	LHCGR, ATF1, CD14, FGF2, APC, GNAS
17	acth32	8.1	LHCGR, SCARB1, CDKN1C, INHA, APC, MC2R
18	estrone32 9 18 9	11.1	IGFBP1, IGF2, IGFBP2, IGFBP3, IGF1, HSD3BP4
19	norepinephrine32 9 18 9	11.0	SDHB, CHGB, CHGA, ATF1, CD14, MMP2
20	glycogen32 18	9.0	VHL, MYC, SDHB, CHGA, MTOR, AXIN2
21	gefitinib32 34 9 9	10.9	VEGFA, MTOR, CDK2, CDK4, MMP2, FGF2
22	cysteine32	7.9	SDHB, CGB, CD14, CDKN2A, MMP2, GTF3A
23	octreotide32 42 9 9	10.9	VEGFA, CHGA, MMP2, MKI67, ENO2, IGFBP1
24	dihydrotestosterone32 9 18 9	10.8	CDK2, CDK4, FGF2, IGFBP1, IGF2, IGFBP2
25	cyclic amp32 18	8.5	PDE11A, RET, CNC, BRAF, LHCGR, SCARB1
26	arginine32	7.4	RET, BRAF, SDHB, LHCGR, CHGA, CDK2
27	doxorubicin32 34 9 9	10.2	BUB1B, MTOR, CDK2, CDK4, MKI67, MDM2
28	cholesterol32 9 18 9	10.1	SDHB, SDHC, LHCGR, SCARB1, CHGA, CDK2
29	calcium32 9 18 9	10.1	BRAF, VHL, SDHB, LHCGR, CHGB, ATF1
30	5-aza-2deoxycytidine32	7.0	VHL, MYC, CDKN2A, CDKN1C, MDM2, APC
31	phosphatidylinositol32	6.9	RET, BRAF, VHL, MYC, LHCGR, SCARB1
32	ribonucleic acid32	6.8	RET, MYC, LHCGR, SCARB1, CHGA, MMP2
33	pd 98,05932	6.8	RET, BRAF, MYC, MTOR, ATF1, CDK2
34	resveratrol32 9 18 9	9.7	VEGFA, MTOR, CDK2, CD14, CDK4, MMP2
35	thymidine32 18	7.7	MYC, CDK2, CDK4, MKI67, GTF3A, FGF2
36	vitamin d32	6.6	CHGA, CDK2, CD14, CDK4, MEN1, APC
37	progesterone32 42 9 18 9	10.3	BRAF, LHCGR, SCARB1, CHGA, CGB, CGB7
38	cisplatin32 34 9 9	9.3	BRAF, VEGFA, MYC, CHGA, MTOR, CGB
39	tamoxifen32 34 9 9	9.2	VEGFA, MYC, CHGA, MTOR, CDK2, MKI67
40	testosterone32 9 18 9	8.9	RET, SDHB, LHCGR, SCARB1, CHGA, MTOR
41	alanine32	5.7	RET, BRAF, MYC, LHCGR, SCARB1, CGB
42	lipid32	5.6	RET, BRAF, SDHB, SCARB1, CHGA, MTOR
43	paclitaxel32 34 9 9	8.5	BUB1B, BRAF, VEGFA, MYC, CHGA, AURKA
44	estrogen32	5.1	VHL, LHCGR, SCARB1, CHGB, CHGA, CGB
45	genistein32 9 18 9	7.1	RET, VEGFA, MYC, MTOR, CDK2, CDKN2A
46	dexamethasone32 42 34 9 9	8.1	VEGFA, MYC, CHGB, CHGA, MTOR, CDK2
47	retinoic acid32 42 18	5.9	RET, BRAF, MYC, SDHC, CHGA, MTOR
48	tyrosine32	3.9	RET, BRAF, VHL, VEGFA, MYC, SDHB
49	cycloheximide32	3.5	VEGFA, MYC, CHGA, CDK2, CD14, CDKN2A
50	vegf32	2.1	RET, BRAF, VHL, VEGFA, MYC, SDHB

Cellular components related to adrenocortical tumor according to GeneDecks:

(show all 13)

id	Name	GO ID	Score	Top Affiliating Genes
1	mitochondrial respiratory chain complex II	GO:005749	10.3	SDHB, SDHC, SDHD
2	cyclin-dependent protein kinase holoenzyme complex	GO:000307	10.3	CCND2, CCNE1, CDK4, CDK2
3	Axin-APC-beta-catenin-GSK3B complex	GO:034747	10.0	CTNNB1, APC, AXIN2
4	neuronal cell body	GO:043025	9.8	HDC, NOV, SRD5A1, CYP19A1, CYP17A1, CCNG1
5	secretory granule	GO:030141	9.7	POMC, THBS1, GHRL, CHGA, CHGB, VEGFA
6	transcription factor complex	GO:005667	9.3	GATA6, CREM, CREB1, CTNNB1, CDK4, CDK2
7	nuclear body	GO:016604	9.2	MYC, CDKN2A, MDM2, TP53
8	extracellular space	GO:005615	8.2	AKR1B1, GHRL, PTHLH, THBS1, POMC, WNT4
9	extracellular region	GO:005576	7.8	IGF1, GNAS, ESR2, GHRL, PTHLH, NOV
10	cytosol	GO:005829	6.6	CCND2, GNAS, GLI1, HRAS, AKR1B1, TP53
11	nucleoplasm	GO:005654	6.4	VHL, TERT, PPARG, NR0B1, NR2F1, NR5A1
12	cytoplasm	GO:005737	5.0	NR0B1, CTNNB1, PTHLH, TERT, TP53, AKR1B1
13	nucleus	GO:005634	3.8	PPARG, CTNNB1, DLGAP5, PTHLH, TP53, ESR2

Biological processes related to adrenocortical tumor according to GeneDecks:

(show all 50)

id	Name	GO ID	Score	Top Affiliating Genes
1	cellular response to gonadotropin stimulus	GO:071371	10.7	GATA6, CYP17A1, LHCGR
2	androgen biosynthetic process	GO:006702	10.6	WNT4, SRD5A1, CYP17A1, SCARB1
3	phthalate metabolic process	GO:018963	10.6	CYP19A1, CYP17A1, CYP11A1
4	mineralocorticoid biosynthetic process	GO:006705	10.6	CYP21A2, CYP11B1, CYP11B2
5	biphenyl metabolic process	GO:018879	10.6	CYP19A1, CYP17A1, CYP11A1
6	male gonad development	GO:008584	10.6	GATA4, GATA6, WNT4, NR5A1, NR0B1, SRD5A1
7	steroid biosynthetic process	GO:006694	10.5	CYP17A1, CYP19A1, NR0B1, STAR
8	dibenzo-p-dioxin metabolic process	GO:018894	10.5	CYP19A1, CYP17A1, CYP11A1, CYP1A2
9	glucocorticoid biosynthetic process	GO:006704	10.5	CYP21A2, CYP17A1, CYP11B1
10	response to fungicide	GO:060992	10.5	SRD5A1, CYP17A1, CYP11A1
11	C21-steroid hormone biosynthetic process	GO:006700	10.5	STAR, CYP11B1, CYP11A1, CYP11B2, AKR1B1, FGF2
12	adrenal gland development	GO:030325	10.4	WNT4, NF1, NR5A1, NR0B1, CYP19A1, CYP17A1
13	cellular response to follicle-stimulating hormone stimulus	GO:071372	10.4	GATA4, CYP19A1, CYP11A1
14	liver development	GO:001889	10.3	GATA6, WNT4, NF1, SRD5A1, CCND2, CCNE1
15	steroid metabolic process	GO:008202	10.3	STAR, SRD5A1, CYP21A2, CYP19A1, CYP17A1, CYP11B1
16	pituitary gland development	GO:021983	10.3	CREB1, NR0B1, SRD5A1, GLI1
17	response to stress	GO:006950	10.3	NR0B1, CYP11B1, AKR1B1, IGFBP2, VHL, PINK1
18	xenobiotic metabolic process	GO:006805	10.2	CYP21A2, CYP19A1, CYP17A1, CYP11B1, CYP11A1, CYP1A2
19	positive regulation of DNA replication	GO:045740	10.1	PDGFRA, HRAS, GLI1, IGF1, ATF1
20	cell-cell signaling	GO:007267	9.9	GATA4, ADM, WNT4, PGR, POMC, NR5A1
21	positive regulation of angiogenesis	GO:045766	9.9	GATA4, GATA6, ADM, THBS1, FGF2, VEGFA
22	positive regulation of cell division	GO:051781	9.9	IGF2, APC, MEN1, FGF2, VEGFA
23	positive regulation of protein phosphorylation	GO:001934	9.8	HRAS, IGF2, CCND2, AXIN2, MTOR, VEGFA
24	response to gamma radiation	GO:010332	9.8	CYP11A1, TP53, MEN1, MYC
25	response to estradiol stimulus	GO:032355	9.7	CTNNB1, CYP19A1, ESR1, IGFBP2, CCND2, CCNE1
26	cellular response to hypoxia	GO:071456	9.6	GATA6, TP53, MDM2, MTOR, VEGFA, VHL
27	canonical Wnt receptor signaling pathway	GO:060070	9.6	GATA4, WNT4, CTNNB1, APC, MYC
28	fibroblast growth factor receptor signaling pathway	GO:008543	9.5	PRKAR2B, PRKAR1A, CREB1, HRAS, MDM2, FGF2
29	negative regulation of cell-matrix adhesion	GO:001953	9.5	CDKN2A, NF1, THBS1
30	nerve growth factor receptor signaling pathway	GO:048011	9.5	PRKAR2B, PRKAR1A, CREB1, HRAS, MDM2, ATF1
31	positive regulation of apoptotic process	GO:043065	9.5	GATA6, TLR4, NF1, CTNNB1, TP53, ESR2
32	small molecule metabolic process	GO:044281	9.4	CYP17A1, CYP19A1, CYP21A2, SRD5A1, ACADVL, STAR
33	phosphatidylinositol-mediated signaling	GO:048015	9.4	PDGFRA, CREB1, IGF1, MDM2, AURKA, MTOR
34	positive regulation of peptidyl-tyrosine phosphorylation	GO:050731	9.3	TLR4, TP53, IGF1, IGF2, MTOR, VEGFA
35	cell cycle arrest	GO:007050	9.3	THBS1, TP53, HRAS, APC, MEN1, INHA
36	MAPK cascade	GO:000165	9.3	NF1, HRAS, MEN1, MYC, RET
37	Ras protein signal transduction	GO:007265	9.2	NF1, TP53, HRAS, IGF1, FGF2, CDKN2A
38	response to estrogen stimulus	GO:043627	9.1	GATA4, GATA6, PPARG, CYP11A1, GHRL, ESR1
39	blood coagulation	GO:007596	9.0	GATA4, GATA6, PRKAR2B, PRKAR1A, THBS1, TP53
40	protein phosphorylation	GO:006468	8.9	IGFBP3, CCNE1, CDK4, AURKA, MTOR, BRAF
41	negative regulation of transcription, DNA-dependent	GO:045892	8.8	GATA6, WNT4, NR0B1, PPARG, CTNNB1, TP53
42	negative regulation of apoptotic process	GO:043066	8.8	GATA6, WNT4, NES, THBS1, TP53, GHRL
43	negative regulation of transcription from RNA polymerase II promoter	GO:000122	8.7	GATA6, NR2F1, NR0B1, PPARG, TP53, ESR2
44	negative regulation of cell proliferation	GO:008285	8.6	ALOX15B, HRAS, TP53, PTHLH, CTNNB1, ADM
45	transcription initiation from RNA polymerase II promoter	GO:006367	8.4	PGR, NR5A1, NR2F1, NR0B1, PPARG, ESR2
46	positive regulation of cell proliferation	GO:008284	8.2	HTR4, GLI1, HRAS, PTHLH, PDGFRA, ADM
47	response to drug	GO:042493	8.1	MYC, GATA4, GATA6, NES, THBS1, CREB1
48	positive regulation of transcription, DNA-dependent	GO:045893	7.3	GLI1, TP53, CTNNB1, PPARG, CREB1, WNT4
49	signal transduction	GO:007165	6.7	ESR2, PPARG, NR2F1, CREB1, CREM, PRKAR1A
50	positive regulation of transcription from RNA polymerase II promoter	GO:045944	6.2	CTNNB1, PPARG, NR5A1, CREB1, TLR4, POMC

Molecular functions related to adrenocortical tumor according to GeneDecks:

(show all 16)

id	Name	GO ID	Score	Top Affiliating Genes
1	peptide hormone binding	GO:017046	10.3	PRLHR, GHSR, GIPR, LHCGR
2	RNA polymerase II distal enhancer sequence-specific DNA binding transcription factor activity	GO:003705	10.2	GATA4, GATA6, CREB1, NR5A1, GLI1, ATF1
3	insulin-like growth factor binding	GO:005520	10.1	NOV, IGFBP3, IGF2R, IGFBP1
4	iron ion binding	GO:005506	10.1	CYP21A2, CYP19A1, CYP17A1, CYP11B1, CYP11A1, CYP1A2
5	heme binding	GO:020037	10.1	CYP21A2, CYP19A1, CYP17A1, CYP11B1, CYP11A1, CYP1A2
6	electron carrier activity	GO:009055	9.9	CYP11B1, CYP17A1, CYP19A1, CYP21A2, SRD5A1, CYP11A1
7	hormone activity	GO:005179	9.8	ADM, POMC, PRLH, CRHR2, PTHLH, IGF1
8	ligand-activated sequence-specific DNA binding RNA polymerase II transcription factor activity	GO:004879	9.7	NR5A1, NR2F1, NR0B1, PPARG, ESR2
9	double-stranded DNA binding	GO:003690	9.6	GATA6, CREB1, NR5A1, NR0B1, CTNNB1, MEN1
10	chromatin binding	GO:003682	9.2	GATA4, GATA6, NR5A1, PPARG, CTNNB1, TP53
11	transcription regulatory region DNA binding	GO:044212	9.2	GATA6, PPARG, CTNNB1, TP53, GLI1, MEN1
12	transcription factor binding	GO:008134	9.1	GATA4, GATA6, NR0B1, CTNNB1, TP53, CDKN2A
13	steroid binding	GO:005496	9.0	PGR, CYP21A2, ESR2, ESR1
14	steroid hormone receptor activity	GO:003707	8.8	PGR, NR5A1, NR2F1, NR0B1, PPARG, ESR2
15	enzyme binding	GO:019899	8.1	PGR, NR5A1, PPARG, CTNNB1, CYP1A2, TP53
16	protein binding	GO:005515	2.0	GATA4, NR0B1, PPARG, CTNNB1, DLGAP5, TERT