MCID: ADL052
MIFTS: 54

Adult Acute Lymphocytic Leukemia malady

Genetic diseases, Cancer diseases, Immune diseases, Rare diseases, Blood diseases categories
Download this MalaCard

Summaries for Adult Acute Lymphocytic Leukemia

About this section


Fully expand this MalaCard
MalaCards based summary: Adult Acute Lymphocytic Leukemia, also known as adult acute lymphoid leukemia, is related to non-hodgkin lymphoma and leukemia. An important gene associated with Adult Acute Lymphocytic Leukemia is SHMT1 (serine hydroxymethyltransferase 1 (soluble)), and among its related pathways are folate polyglutamylation and E2F mediated regulation of DNA replication. The compounds ch2h4folate and 5-Methyltetrahydrofolic acid have been mentioned in the context of this disorder. Affiliated tissues include bone, bone marrow and breast, and related mouse phenotypes are limbs/digits/tail and skeleton.

Aliases & Classifications for Adult Acute Lymphocytic Leukemia

About this section

Adult Acute Lymphocytic Leukemia, Aliases & Descriptions:

Name: Adult Acute Lymphocytic Leukemia 30 8 10 44 62
 
Adult Acute Lymphoid Leukemia 8


Classifications:



External Ids:

Disease Ontology8 DOID:5604
NCIt39 C4967

Related Diseases for Adult Acute Lymphocytic Leukemia

About this section

Diseases in the Chronic Lymphocytic Leukemia family:

Acute Lymphocytic Leukemia adult acute lymphocytic leukemia
Familial Acute Lymphocytic Leukemia Familial Chronic Lymphocytic Leukemia
Leukemia, Chronic Lymphocytic 4 Leukemia, Chronic Lymphocytic 3
Leukemia, Acute Lymphocytic 1 Leukemia, Chronic Lymphocytic 1
Leukemia, Chronic Lymphocytic 5 Leukemia, Chronic Lymphocytic 2

Diseases related to Adult Acute Lymphocytic Leukemia via text searches within MalaCards or GeneCards/GeneDecks gene sharing:

(show top 50)    (show all 73)
idRelated DiseaseScoreTop Affiliating Genes
1non-hodgkin lymphoma30.2MTR, CSF3, CDKN2B, CD34
2leukemia29.7ABCG2, TYMS, MME, MTHFR, MTR, CSF3
3breast cancer28.4ABCG2, TYMS, SHMT1, MME, MTHFR, MTR
4acute lymphocytic leukemia11.1
5macroglossia10.5CDKN1C
6hematopoietic stem cell transplantation10.4
7t-cell adult acute lymphocytic leukemia10.4
8gallbladder cancer10.3CDX2, TYMS
9esophagitis10.3CDX2, CDX1
10leukemia, acute nonlymphocytic10.3CD34, TYMS
11refractory anemia10.3CDKN2B, CSF3
12tubular adenocarcinoma10.3MME, CDX2
13malignant peripheral nerve sheath tumor10.3CDKN2B, CD34
14gastric adenocarcinoma10.3CDKN2B, CDX2, TYMS
15lymphoid leukemia10.2
16stomatitis10.2TYMS, CSF3
17endometrial carcinoma10.2CDX2, MME
18gastritis10.2CD34, CDX2
19severe combined immunodeficiency10.2
20neurofibromatosis10.2
21factor vii deficiency10.2TYMS, CSF3
22precursor t-cell acute lymphoblastic leukemia10.2TYMS, CDKN2B, CD34
23leukopenia10.2TYMS, CSF3
24leukemia, acute lymphoblastic 310.1MME, CDKN2B, CD34
25homocysteinemia due to mthfr deficiency10.1MTR, MTHFR
26immunodeficiency with hyper igm type 210.1TYMS, MME, MTR
27pneumonia10.1TYMS, MME, CSF3
28multiple sclerosis10.1MTR, MME
29aplastic anemia10.1CD34, CSF3
30megaloblastic anemia10.1MTHFR, MTR
31homocysteinemia10.1MTR, MTHFR
32methylmalonic acidemia10.1MTHFR, MTR
33neutropenia10.1TYMS, CSF3, CD34
34vitamin b12 deficiency10.1MTHFR, MTR
35pancreatic cancer10.1ABCG2, TYMS, CDX2
36bladder carcinoma10.1TYMS, MTR, CDKN1C, CDKN2B
37leiomyosarcoma10.1CD34, MME
38acute myeloid leukemia, adult10.1ABCG2, CDKN2B, CD34
39homocystinuria10.0MTHFR, MTR
40choriocarcinoma10.0ABCG2, MME, CDKN1C
41myeloid leukemia10.0CD34, CDKN2B, CSF3
42cerebrovascular disease10.0MTR, MTHFR
43retinoblastoma10.0CDKN2B, CDKN1C, TYMS, ABCG2
44thromboembolism10.0MTHFR, MTR
45folic acid deficiency anemia10.0TYMS, MTHFR, MTR
46hyperhomocysteinemia10.0MTR, MTHFR, TYMS
47lung cancer10.0ABCG2, TYMS, CDX2
48spina bifida10.0MTR, MTHFR
49colonic benign neoplasm10.0CDX1, CDX2, TYMS, ABCG2
50b-cell lymphomas10.0CDKN2B, CDKN1C, MME, ABCG2

Graphical network of the top 20 diseases related to Adult Acute Lymphocytic Leukemia:



Diseases related to adult acute lymphocytic leukemia

Symptoms for Adult Acute Lymphocytic Leukemia

About this section

Drugs & Therapeutics for Adult Acute Lymphocytic Leukemia

About this section

Drug clinical trials:

Search ClinicalTrials for Adult Acute Lymphocytic Leukemia

Search NIH Clinical Center for Adult Acute Lymphocytic Leukemia

Cell-based therapeutics:


LifeMap Discovery
The database of embryonic development, stem cell research and regenerative medicine
Read about Adult Acute Lymphocytic Leukemia cell therapies at LifeMap Discovery.

Genetic Tests for Adult Acute Lymphocytic Leukemia

About this section

Anatomical Context for Adult Acute Lymphocytic Leukemia

About this section

MalaCards organs/tissues related to Adult Acute Lymphocytic Leukemia:

32
Bone, Bone marrow, Breast, Testes, Myeloid

LifeMap Discovery
The database of embryonic development, stem cell research and regenerative medicine

Cells/anatomical compartments in embryo or adult related to Adult Acute Lymphocytic Leukemia:
id TissueAnatomical CompartmentCell Relevance
1 BloodHematopoietic Bone MarrowHematopoietic Stem Cells Potential therapeutic candidate
2 BloodPeripheral BloodMature B-Cells Potential therapeutic candidate, affected by disease
3 BloodHematopoietic Bone MarrowSmall Pre B-Cells Potential therapeutic candidate, affected by disease

Animal Models for Adult Acute Lymphocytic Leukemia or affiliated genes

About this section

MGI Mouse Phenotypes related to Adult Acute Lymphocytic Leukemia:

36
idDescriptionMGI Source AccessionScoreTop Affiliating Genes
1MP:00053718.8CDX4, CDKN1C, CDX2, MTHFR
2MP:00053908.2MTHFR, CDX2, CDKN1C, CDX1, CDX4
3MP:00107717.7ABCG2, MME, MTHFR, CSF3, CDKN2B, CD34
4MP:00053977.2ABCG2, CSF3, CDKN1C, CDX1, CDX4, CDKN2B
5MP:00053766.4CD34, ABCG2, SHMT1, MME, MTHFR, MTR

Publications for Adult Acute Lymphocytic Leukemia

About this section

Articles related to Adult Acute Lymphocytic Leukemia:

(show top 50)    (show all 62)
idTitleAuthorsYear
1
Medical history, lifestyle, family history, and occupational risk factors for adult acute lymphocytic leukemia: the InterLymph Non-Hodgkin Lymphoma Subtypes Project. (25174033)
2014
2
Serum peptidome based biomarkers searching for monitoring minimal residual disease in adult acute lymphocytic leukemia. (25317080)
2014
3
The Effect of GVHD on Long-term Outcomes after Peripheral Blood Allogeneic Stem Cell Transplantation from an HLA-identical Sibling in Adult Acute Lymphocytic Leukemia: A Landmark Analysis Approach in Competing Risks. (24800032)
2014
4
Expression and clinical significance of caudal type homeobox transcription factor-2 in adult acute lymphocytic leukemia]. (21518475)
2011
5
Novel targets for treatment of adult acute lymphocytic leukemia. (20680526)
2010
6
Allogeneic hematopoietic stem cell transplantation for adult acute lymphocytic leukemia. (20425427)
2009
7
Gene expression of breast cancer resistance protein in adult acute lymphocytic leukemia and its clinical significance]. (18315895)
2008
8
Phase II study of sphingosomal vincristine in patients with recurrent or refractory adult acute lymphocytic leukemia. (16331634)
2006
9
Protein expression of a triad of frequently methylated genes, p73, p57Kip2, and p15, has prognostic value in adult acute lymphocytic leukemia independently of its methylation status. (15851765)
2005
10
Long-term follow-up results of hyperfractionated cyclophosphamide, vincristine, doxorubicin, and dexamethasone (Hyper-CVAD), a dose-intensive regimen, in adult acute lymphocytic leukemia. (15481055)
2004
11
Treatment outcome of adult acute lymphocytic leukemia with VPD(L) regimen: analysis of prognostic factors. (12760264)
2003
12
Aberrant DNA methylation of p57KIP2 identifies a cell-cycle regulatory pathway with prognostic impact in adult acute lymphocytic leukemia. (12586619)
2003
13
Polymorphisms in the thymidylate synthase and serine hydroxymethyltransferase genes and risk of adult acute lymphocytic leukemia. (11986237)
2002
14
DNA methylation of multiple promoter-associated CpG islands in adult acute lymphocytic leukemia. (12114423)
2002
15
DNA methylation patterns at relapse in adult acute lymphocytic leukemia. (12060634)
2002
16
Cytogenetic aberrations in adult acute lymphocytic leukemia: optimal technique may influence the results. (11454422)
2001
17
Rare adult acute lymphocytic leukemia with CD56 expression in the ECOG experience shows unexpected phenotypic and genotypic heterogeneity. (11279625)
2001
18
Induction therapy of adult acute lymphocytic leukemia without the use of vincristine or prednisone. (11253603)
2001
19
The hyper-CVAD regimen in adult acute lymphocytic leukemia. (11147229)
2000
20
The Medical Research Council trials in adult acute lymphocytic leukemia. (11147226)
2000
21
Adult acute lymphocytic leukemia study testing chemotherapy and autologous and allogeneic transplantation. A follow-up report of the French protocol LALA 87. (11147227)
2000
22
Cytogenetics in adult acute lymphocytic leukemia. (11147221)
2000
23
Adult acute lymphocytic leukemia. Introduction and questions related to current programs. (11147219)
2000
24
Insights into the biologic and molecular abnormalities in adult acute lymphocytic leukemia. (11147223)
2000
25
Results of treatment with hyper-CVAD, a dose-intensive regimen, in adult acute lymphocytic leukemia. (10653870)
2000
26
Deletions and losses in chromosomes 5 or 7 in adult acute lymphocytic leukemia: incidence, associations and implications. (10360374)
1999
27
Familial neurofibromatosis type I and adult acute lymphocytic leukemia. (10329933)
1999
28
Analysis of the BCR-ABL protein in Philadelphia chromosome-positive adult acute lymphocytic leukemia. (9305617)
1997
29
Avascular necrosis of bone after adult acute lymphocytic leukemia treatment with methotrexate, vincristine, L-asparaginase, and dexamethasone (MOAD). (8756084)
1996
30
Growth and biologic properties of karyotypically defined subcategories of adult acute lymphocytic leukemia in mice with severe combined immunodeficiency. (7492788)
1995
31
Myeloid markers in adult acute lymphocytic leukemia. Correlations with patient and disease characteristics and with prognosis. (8635059)
1995
32
Philadelphia-chromosome-positive adult acute lymphocytic leukemia: characteristics, treatment results, and prognosis in 41 patients. (8030658)
1994
33
The role of bone marrow transplantation in adult acute lymphocytic leukemia. (8338797)
1993
34
Prognostic significance of elevated serum beta 2-microglobulin levels in adult acute lymphocytic leukemia. (1466355)
1992
35
Adult acute lymphocytic leukemia: the Eastern Cooperative Oncology Group experience. (1578927)
1992
36
Treatment of relapsed or refractory adult acute lymphocytic leukemia. (1730121)
1992
37
Phase III trial of brief intensive treatment of adult acute lymphocytic leukemia comparing daunorubicin and mitoxantrone: a CALGB Study. (2033963)
1991
38
The effects of postinduction intensification treatment with cytarabine and daunorubicin in adult acute lymphocytic leukemia: a prospective randomized clinical trial by Cancer and Leukemia Group B. (1941059)
1991
39
Evaluation of cytogenetic samples and pertinent technical variables in adult acute lymphocytic leukemia. (2009514)
1991
40
Improved results of an intensified therapy in adult acute lymphocytic leukemia. (2009234)
1991
41
Testicular relapse in adult acute lymphocytic leukemia: a case report and literature review. (2649778)
1989
42
Low-dose cytosine arabinoside as remission induction therapy in refractory adult acute lymphocytic leukemia. (2929641)
1989
43
Phase II evaluation of teniposide and ifosfamide in refractory adult acute lymphocytic leukemia: a Southwest Oncology Group Study. (3475171)
1987
44
Repeated high-dose cyclophosphamide, BCNU and VP-16-213 and autologous bone marrow transplantation in adult acute lymphocytic leukemia in first remission. (6376130)
1984
45
Treatment of adult acute lymphocytic leukemia. (6953291)
1982
46
Moderate dose methotrexate, vincristine, asparaginase, and dexamethasone for treatment of adult acute lymphocytic leukemia. (7034815)
1982
47
Effective multidrug, multimodality consolidation therapy of adult acute lymphocytic leukemia: a preliminary report. (6977407)
1982
48
High-dose methotrexate for the remission induction of refractory adult acute lymphocytic leukemia. (370537)
1978
49
Remission induction in adult acute lymphocytic leukemia. Use of vincristine and prednisone alone. (1067890)
1976
50
Combination chemotherapy of adult acute lymphocytic leukemia. (770047)
1976

Variations for Adult Acute Lymphocytic Leukemia

About this section

Expression for genes affiliated with Adult Acute Lymphocytic Leukemia

About this section
Expression patterns in normal tissues for genes affiliated with Adult Acute Lymphocytic Leukemia

Search GEO for disease gene expression data for Adult Acute Lymphocytic Leukemia.

Pathways for genes affiliated with Adult Acute Lymphocytic Leukemia

About this section

Pathways related to Adult Acute Lymphocytic Leukemia according to GeneCards/GeneDecks:

idSuper pathways (with members indented)ScoreTop Affiliating Genes
1
Show member pathways
Glycine Metabolism37
glycine biosynthesis I37
folate transformations37
9.9MTR, SHMT1
2
Show member pathways
9.7CDKN2B, CDKN1C, TYMS
3
Show member pathways
L-serine degradation37
pentose phosphate pathway (oxidative branch)37
formaldehyde oxidation II (glutathione-dependent)37
9.4SHMT1, MTHFR, MTR
4
Show member pathways
flavin biosynthesis IV (mammalian)37
molybdenum cofactor biosynthesis37
coenzyme A biosynthesis37
thiamin salvage III37
alanine biosynthesis III37
thio-molybdenum cofactor biosynthesis37
biotin-carboxyl carrier protein assembly37
9.4SHMT1, MTHFR, MTR
5
Show member pathways
9.3ABCG2, TYMS, MTHFR
6
Show member pathways
One Carbon Metabolism37
dTMP de novo biosynthesis (mitochondrial)37
tetrahydrofolate salvage from 5,10-methenyltetrahydrofolate37
Trans-sulfuration and one carbon metabolism37
methionine salvage37
Methionine metabolism60
9.1MTR, MTHFR, SHMT1, TYMS
78.8CD34, CSF3, MME

Compounds for genes affiliated with Adult Acute Lymphocytic Leukemia

About this section

Compounds related to Adult Acute Lymphocytic Leukemia according to GeneCards/GeneDecks:

(show top 50)    (show all 91)
idCompoundScoreTop Affiliating Genes
1ch2h4folate4410.1TYMS, MTHFR
25-Methyltetrahydrofolic acid2410.0MTHFR, MTR
3methyl-group4410.0MTHFR, MTR
4dactinomycin50 1110.9ABCG2, MTR
55,10-Methylene-THF249.9TYMS, MTHFR, SHMT1
6edatrexate449.9TYMS, CSF3
7pemetrexed50 1110.9TYMS, MTHFR
85,10-methenyltetrahydrofolate449.8MTR, MTHFR
9adenosylcobalamin44 2410.8MTR, MTHFR
10Tetrahydrofolic acid24 1110.8MTHFR, SHMT1, MTR
11methylcobalamin44 2410.8MTR, MTHFR
12thiopurine449.7ABCG2, TYMS, MTHFR
139-aminocamptothecin449.7CSF3, ABCG2, TYMS
145-aza-2deoxycytidine449.7CDX1, CDX2, CDKN1C, CDKN2B
15vitamin b12449.6MTR, TYMS, MTHFR
1610-formyltetrahydrofolate449.6MTHFR, MTR
17vinorelbine44 50 1111.6TYMS, CSF3, ABCG2
18oxaliplatin44 50 1111.6ABCG2, MTHFR, TYMS
19b vitamins449.6TYMS, MTR, MTHFR, SHMT1
20tetrahydrofolate449.6TYMS, MTHFR, MTR, SHMT1
21topotecan44 1110.6ABCG2, TYMS, CSF3
22vitamin b6449.6TYMS, MTR, MTHFR, SHMT1
23pyridoxal 5-phosphate449.6SHMT1, TYMS, MTR, MTHFR
24fluorouracil50 1110.5TYMS, ABCG2, SHMT1, MTHFR
25purine44 2410.5MTHFR, SHMT1, TYMS, MTR
26thymidylate449.5MTR, MTHFR, SHMT1, TYMS
276 mercaptopurine449.5MTHFR, CSF3, ABCG2
28leucovorin44 50 1111.4SHMT1, MTHFR, CSF3, TYMS
29ara-ctp449.4TYMS, CSF3
30zidovudine44 50 1111.3TYMS, CSF3, ABCG2
31methionine449.3MME, MTHFR, SHMT1, MTR
32adriamycin449.3ABCG2, TYMS, MME, CSF3
33hydroxyurea44 50 1111.3TYMS, CSF3, ABCG2
34taxane449.3ABCG2, TYMS, CSF3, MTHFR
35carboplatin44 50 1111.2TYMS, MTHFR, CSF3, ABCG2
36gemcitabine44 50 1111.2MTHFR, CSF3, ABCG2, TYMS
37valine449.2TYMS, MTHFR, MTR, CSF3
38mitomycin c449.2TYMS, CSF3, ABCG2
39folate449.2MTR, TYMS, MTHFR, SHMT1, ABCG2
40cytarabine44 50 1111.1CDKN2B, CSF3, MME, TYMS, ABCG2
415fluorouracil449.1CSF3, ABCG2, MTHFR, TYMS
42cyclophosphamide44 50 1111.1ABCG2, CSF3, MTR, MTHFR
43irinotecan44 50 1111.0CSF3, SHMT1, TYMS, ABCG2, MTHFR
44doxorubicin44 50 1110.9CSF3, MTR, MME, ABCG2, TYMS
45dihydrofolate448.9ABCG2, TYMS, SHMT1, MTHFR, MTR, CDKN2B
46cisplatin44 50 61 1111.8MTHFR, CSF3, MTR, TYMS, ABCG2
47methotrexate50 44 1110.4TYMS, SHMT1, MTHFR, MTR, ABCG2, CDKN2B
48thymidine44 249.2CDX2, TYMS, MME, MTHFR, CSF3, CD34
49retinoic acid44 249.1CSF3, MTHFR, CDX1, MME, CDKN2B, CD34
50estrogen447.9CD34, CDKN2B, CDX2, MTR, MTHFR, MME

GO Terms for genes affiliated with Adult Acute Lymphocytic Leukemia

About this section

Biological processes related to Adult Acute Lymphocytic Leukemia according to GeneCards/GeneDecks:

(show all 16)
idNameGO IDScoreTop Affiliating Genes
1negative regulation of protein serine/threonine kinase activityGO:07190110.1CDKN1C, CDKN2B
2tetrahydrofolate interconversionGO:03599910.1MTHFR, SHMT1
3positive regulation of transforming growth factor beta receptor signaling pathwayGO:03051110.0CDKN2B, CDKN1C
4folic acid metabolic processGO:04665510.0SHMT1, MTHFR
5negative regulation of phosphorylationGO:04232610.0CDKN2B, CDKN1C
6response to folic acidGO:05159310.0MTHFR, TYMS
7negative regulation of epithelial cell proliferationGO:0506809.9CDKN2B, CDKN1C
8labyrinthine layer developmentGO:0607119.8CDX4, CDX2
9cellular response to cytokine stimulusGO:0713459.8CSF3, MME
10water-soluble vitamin metabolic processGO:0067679.7MTR, MTHFR, SHMT1
11vitamin metabolic processGO:0067669.7MTR, MTHFR, SHMT1
12anterior/posterior pattern specificationGO:0099529.5CDX2, CDX1, CDX4
13blood vessel developmentGO:0015689.4CDX4, CDX2
14negative regulation of neuron deathGO:19012159.4CD34, CSF3
15response to drugGO:0424939.0MTHFR, TYMS, ABCG2
16small molecule metabolic processGO:0442818.7ABCG2, TYMS, SHMT1, MTHFR, MTR

Molecular functions related to Adult Acute Lymphocytic Leukemia according to GeneCards/GeneDecks:

idNameGO IDScoreTop Affiliating Genes
1cyclin-dependent protein serine/threonine kinase inhibitor activityGO:0048619.9CDKN2B, CDKN1C

Products for genes affiliated with Adult Acute Lymphocytic Leukemia

About this section
  • Antibodies
  • Proteins
  • Lysates

Sources for Adult Acute Lymphocytic Leukemia

About this section
3CDC
13ExPASy
14FMA
22GTR
23HGMD
24HMDB
25ICD10
26ICD10 via Orphanet
27ICD9CM
28IUPHAR
29KEGG
34MeSH
35MESH via Orphanet
36MGI
39NCIt
40NDF-RT
43NINDS
44Novoseek
46OMIM
47OMIM via Orphanet
51PubMed
52QIAGEN
58SNOMED-CT via Orphanet
62UMLS
63UMLS via Orphanet