MCID: ADL052
MIFTS: 49

Adult Acute Lymphocytic Leukemia malady

Immune diseases category

Summaries for Adult Acute Lymphocytic Leukemia

About this section
Sources:
32MalaCards
See all sources

Fully expand this MalaCard

Export this MalaCard
MalaCards: Adult Acute Lymphocytic Leukemia, also known as adult acute lymphoid leukemia, is related to acute leukemia and acute lymphocytic leukemia. An important gene associated with Adult Acute Lymphocytic Leukemia is SHMT1 (serine hydroxymethyltransferase 1 (soluble)), and among its related pathways are Fluoropyrimidine Pathway, Pharmacodynamics and Mitotic G1-G1/S phases. The compounds ch2h4folate and methyl-group have been mentioned in the context of this disorder. Affiliated tissues include bone, bone marrow and t cells, and related mouse phenotypes are integument and homeostasis/metabolism.

Aliases & Classifications for Adult Acute Lymphocytic Leukemia

About this section
Sources:
8Disease Ontology, 10DISEASES, 44Novoseek, 30LifeMap Discovery™, 60UMLS, 39NCIt
See all sources

Classifications:

Malacards categories (disease lists): (See all malacards categories)
Anatomical: Immune diseases


Aliases & Descriptions:

adult acute lymphocytic leukemia 8 10 44 30 60
adult acute lymphoid leukemia 8


External Ids:

Disease Ontology8 DOID:5604
NCIt39 C4967

Related Diseases for Adult Acute Lymphocytic Leukemia

About this section
Sources:
17GeneCards, 18GeneDecks
See all sources

Diseases in the Acute Lymphocytic Leukemia family:

adult acute lymphocytic leukemia Chronic Lymphocytic Leukemia
Familial Acute Lymphocytic Leukemia Familial Chronic Lymphocytic Leukemia
Leukemia, Chronic Lymphocytic 4 Leukemia, Chronic Lymphocytic 3
Leukemia, Acute Lymphocytic 1 Leukemia, Chronic Lymphocytic 1
Leukemia, Chronic Lymphocytic 5 Leukemia, Chronic Lymphocytic 2

Diseases related to Adult Acute Lymphocytic Leukemia via text searches within MalaCards or GeneCards/GeneDecks gene sharing:

(show top 50)    (show all 85)
idRelated DiseaseScoreTop Affiliating Genes
1acute leukemia31.5CSF3, MTHFR, CDKN2B, CD34, ABCG2
2acute lymphocytic leukemia31.5CSF3, MTHFR, TYMS, CDKN2B, CD34, CDKN1C
3leukemia31.5CSF3, MTHFR, MTR, TYMS, CDKN2B, CDX2
4myeloid leukemia30.2CSF3, CDKN2B, CD34
5breast cancer30.2CSF3, MTHFR, MTR, SHMT1, TYMS, CDX2
6t-cell adult acute lymphocytic leukemia10.3
7neurofibromatosis10.2
8testicular leukemia10.2
9acute myeloid leukemia10.2
10central nervous system leukemia10.2
11severe combined immunodeficiency10.2
12malignant pleural mesothelioma10.0TYMS
13diarrhea10.0TYMS
14hepatoblastoma10.0CDKN1C
15stomach cancer10.0CDX2
16macroglossia10.0CDKN1C
17bile reflux10.0CDX1
18malignant mesothelioma10.0CDKN2B, TYMS
19multiple myeloma10.0CSF3
20vascular disease10.0CD34
21sarcoma10.0CD34
22gallbladder cancer10.0CDX2, TYMS
23esophagitis10.0CDX2, CDX1
24angiosarcoma10.0CD34
25hyperuricemia10.0ABCG2
26cholangiocarcinoma10.0MME, CDX2
27meningioma10.0CDKN2B, CD34
28multiple sclerosis10.0MME, MTR
29osteosarcoma10.0TYMS, ABCG2
30wilms tumor10.0MME, CDKN1C
31lymphoma, diffuse large cell10.0MME, CDKN2B
32migraine10.0MTHFR
33leukemia, acute nonlymphocytic10.0TYMS, CD34
34gastric adenocarcinoma10.0CDX2, CDKN2B, TYMS
35endometrial carcinoma10.0MME, CD34
36eclampsia10.0MTHFR
37myelomeningocele10.0MTHFR
38anencephaly10.0MTHFR
39refractory anemia10.0CDKN2B, CSF3
40glioblastoma multiforme10.0CDKN2B, CDKN1C, ABCG2
41thrombocytopenia10.0CD34, CSF3
42fibrosarcoma10.0ABCG2, CD34
43gastritis10.0CDX2, CD34
44precursor t-cell acute lymphoblastic leukemia10.0CD34, CDKN2B, TYMS
45precursor b-cell acute lymphoblastic leukemia10.0MME, CD34, CDKN2B
46homocystinuria due to mthfr deficiency10.0MTR, MTHFR
47atherosclerosis10.0MTR, MTHFR
48bladder carcinoma10.0CDKN1C, CDKN2B, TYMS, MTR
49spina bifida10.0MTHFR, MTR
50alzheimer's disease10.0MME, MTR

Graphical network of the top 20 diseases related to Adult Acute Lymphocytic Leukemia:



Diseases related to adult acute lymphocytic leukemia

Clinical Features for Adult Acute Lymphocytic Leukemia

About this section

Drugs & Therapeutics for Adult Acute Lymphocytic Leukemia

About this section
Sources:
5CenterWatch, 41NIH Clinical Center, 6ClinicalTrials, 30LifeMap Discovery™, 60UMLS, 40NDF-RT
See all sources

Approved drugs:

Search CenterWatch for Adult Acute Lymphocytic Leukemia

Drug clinical trials:

Search ClinicalTrials for Adult Acute Lymphocytic Leukemia

Search NIH Clinical Center for Adult Acute Lymphocytic Leukemia

Search CenterWatch for Adult Acute Lymphocytic Leukemia

Cell-based therapeutics:


LifeMap Discovery
The database of embryonic development, stem cell research and regenerative medicine
Read about Adult Acute Lymphocytic Leukemia cell therapies at LifeMap Discovery.

Genetic Tests for Adult Acute Lymphocytic Leukemia

About this section

Anatomical Context for Adult Acute Lymphocytic Leukemia

About this section
Sources:
30LifeMap Discovery™, 32MalaCards
See all sources

MalaCards organs/tissues related to Adult Acute Lymphocytic Leukemia:

32
Bone, Bone marrow, T cells, B cells, Breast, Testes, Myeloid

LifeMap Discovery
The database of embryonic development, stem cell research and regenerative medicine

Cells/anatomical compartments in embryo or adult related to Adult Acute Lymphocytic Leukemia:
id TissueAnatomical CompartmentCell Relevance
1 BloodHematopoietic Bone MarrowHematopoietic Stem Cells Potential therapeutic candidate
2 BloodPeripheral BloodMature B-Cells Potential therapeutic candidate, affected by disease
3 BloodHematopoietic Bone MarrowSmall Pre B-Cells Potential therapeutic candidate, affected by disease

Animal Models for Adult Acute Lymphocytic Leukemia or affiliated genes

About this section
Sources:
36MGI
See all sources

MGI Mouse Phenotypes related to Adult Acute Lymphocytic Leukemia:

36
idDescriptionMGI Source AccessionScoreTop Affiliating Genes
1MP:00107718.8ABCG2, MME, CD34, CDKN2B
2MP:00053767.7CDX4, MTHFR, MTR, SHMT1, CDX2, CD34
3MP:00053977.3CSF3, CDKN2B, CDX1, CD34, CDKN1C, CDX4

Publications for Adult Acute Lymphocytic Leukemia

About this section
Sources:
50PubMed
See all sources

Articles related to Adult Acute Lymphocytic Leukemia:

(show top 50)    (show all 92)
idTitleAuthorsYear
1
Expression and clinical significance of caudal type homeobox transcription factor-2 in adult acute lymphocytic leukemia]. (21518475)
2011
2
Pyridoxine treatment of vincristine-induced cranial polyneuropathy in an adult patient with acute lymphocytic leukemia: Case report and review of the literature. (20167372)
2010
3
Outcome of adults with acute lymphocytic leukemia in second or subsequent complete remission. (20078325)
2010
4
Outcome of allogeneic bone marrow transplantation from unrelated donors for adult Philadelphia chromosome-negative acute lymphocytic leukemia in first complete-remission. (20146028)
2010
5
Defining the course and prognosis of adults with acute lymphocytic leukemia in first salvage after induction failure or short first remission duration. (20737576)
2010
6
Peripheral ulcerative keratitis with bilateral optic nerve involvement as an initial presentation of acute lymphocytic leukemia in an adult. (18008055)
2009
7
Residual DNA methylation at remission is prognostic in adult Philadelphia chromosome-negative acute lymphocytic leukemia. (19109226)
2009
8
Outcome of adults with acute lymphocytic leukemia after second salvage therapy. (18846563)
2008
9
A case report of an adult with severe hyperlipidemia during acute lymphocytic leukemia induction therapy successfully treated with plasmapheresis. (19140851)
2008
10
Allogeneic hematopoietic stem cell transplantation in adult acute lymphocytic leukemia: impact of donor source on survival. (19041062)
2008
11
Protein expression of a triad of frequently methylated genes, p73, p57Kip2, and p15, has prognostic value in adult acute lymphocytic leukemia independently of its methylation status. (15851765)
2005
12
Long-term follow-up results of hyperfractionated cyclophosphamide, vincristine, doxorubicin, and dexamethasone (Hyper-CVAD), a dose-intensive regimen, in adult acute lymphocytic leukemia. (15481055)
2004
13
Idarubicin and standard-dose cytosine arabinoside in adults with recurrent and refractory acute lymphocytic leukemia. (15368329)
2004
14
Treatment outcome of adult acute lymphocytic leukemia with VPD(L) regimen: analysis of prognostic factors. (12760264)
2003
15
Phase II study of single agent paclitaxel in adult patients with relapsed acute lymphocytic leukemia. (12795536)
2003
16
Polymorphisms in the thymidylate synthase and serine hydroxymethyltransferase genes and risk of adult acute lymphocytic leukemia. (11986237)
2002
17
DNA methylation patterns at relapse in adult acute lymphocytic leukemia. (12060634)
2002
18
Cytogenetic aberrations in adult acute lymphocytic leukemia: optimal technique may influence the results. (11454422)
2001
19
Autologous stem cell transplantation for acute lymphocytic leukemia in adults. (11253604)
2001
20
Induction therapy of adult acute lymphocytic leukemia without the use of vincristine or prednisone. (11253603)
2001
21
Allogeneic stem cell transplantation for acute lymphocytic leukemia in adults. (11253611)
2001
22
The hyper-CVAD regimen in adult acute lymphocytic leukemia. (11147229)
2000
23
The Medical Research Council trials in adult acute lymphocytic leukemia. (11147226)
2000
24
Adult acute lymphocytic leukemia study testing chemotherapy and autologous and allogeneic transplantation. A follow-up report of the French protocol LALA 87. (11147227)
2000
25
Lymphoma in Castleman's disease, acute lymphocytic leukemia, adult T-cell leukemia and cutaneous T-cell lymphoma accompanied with high serum soluble Fas ligand levels. (10841320)
2000
26
Deletions and losses in chromosomes 5 or 7 in adult acute lymphocytic leukemia: incidence, associations and implications. (10360374)
1999
27
Long-term follow-up results of adult patients with acute lymphocytic leukemia or lymphoblastic lymphoma treated with short-term, alternating non-cross-resistant chemotherapy: Japan Clinical Oncology Group Study 8702. Lymphoma Study Group. (10470659)
1999
28
Hematologic engraftment and reconstitution of immune function post unrelated placental cord blood transplant in an adult with acute lymphocytic leukemia. (9619913)
1998
29
Two cases of mature B-cell acute lymphocytic leukemia with normal karyotype in adults. (8922497)
1996
30
Philadelphia-chromosome-positive adult acute lymphocytic leukemia: characteristics, treatment results, and prognosis in 41 patients. (8030658)
1994
31
Adult acute lymphocytic leukemia: critical review of current knowledge. (8059784)
1994
32
The role of bone marrow transplantation in adult acute lymphocytic leukemia. (8338797)
1993
33
Long-term follow-up of treatment and potential cure of adult acute lymphocytic leukemia with MOAD: a non-anthracycline containing regimen. (8350624)
1993
34
Adult and childhood acute lymphocytic leukemia: are they different diseases? (8416287)
1993
35
Prognostic significance of elevated serum beta 2-microglobulin levels in adult acute lymphocytic leukemia. (1466355)
1992
36
Phase III trial of brief intensive treatment of adult acute lymphocytic leukemia comparing daunorubicin and mitoxantrone: a CALGB Study. (2033963)
1991
37
The effects of postinduction intensification treatment with cytarabine and daunorubicin in adult acute lymphocytic leukemia: a prospective randomized clinical trial by Cancer and Leukemia Group B. (1941059)
1991
38
Evaluation of cytogenetic samples and pertinent technical variables in adult acute lymphocytic leukemia. (2009514)
1991
39
Improved results of an intensified therapy in adult acute lymphocytic leukemia. (2009234)
1991
40
Results of the vincristine, doxorubicin, and dexamethasone regimen in adults with standard- and high-risk acute lymphocytic leukemia. (2189958)
1990
41
Low-dose cytosine arabinoside as remission induction therapy in refractory adult acute lymphocytic leukemia. (2929641)
1989
42
Experience with vincristine, doxorubicin, and dexamethasone (VAD) chemotherapy in adults with refractory acute lymphocytic leukemia. (2659160)
1989
43
Identification of risk groups for development of central nervous system leukemia in adults with acute lymphocytic leukemia. (3052630)
1988
44
Phase II evaluation of teniposide and ifosfamide in refractory adult acute lymphocytic leukemia: a Southwest Oncology Group Study. (3475171)
1987
45
Repeated high-dose cyclophosphamide, BCNU and VP-16-213 and autologous bone marrow transplantation in adult acute lymphocytic leukemia in first remission. (6376130)
1984
46
Treatment of adult acute lymphocytic leukemia. (6953291)
1982
47
Moderate dose methotrexate, vincristine, asparaginase, and dexamethasone for treatment of adult acute lymphocytic leukemia. (7034815)
1982
48
Effective multidrug, multimodality consolidation therapy of adult acute lymphocytic leukemia: a preliminary report. (6977407)
1982
49
Remission induction with daunomycin, vincristine, and prednisone in adult acute lymphocytic leukemia. (266674)
1977
50
Remission induction in adult acute lymphocytic leukemia. Use of vincristine and prednisone alone. (1067890)
1976

Genetic Variations for Adult Acute Lymphocytic Leukemia

About this section

Expression for genes affiliated with Adult Acute Lymphocytic Leukemia

About this section
Sources:
1BioGPS, 15Gene Expression Omnibus DataSets
See all sources
Expression patterns in normal tissues for genes affiliated with Adult Acute Lymphocytic Leukemia

Search GEO for disease gene expression data for Adult Acute Lymphocytic Leukemia.

Pathways for genes affiliated with Adult Acute Lymphocytic Leukemia

About this section
Sources:
49PharmGKB, 53Reactome, 37NCBI BioSystems Database, 29KEGG
See all sources

Compounds for genes affiliated with Adult Acute Lymphocytic Leukemia

About this section
Sources:
44Novoseek, 49PharmGKB, 11DrugBank, 24HMDB, 59Tocris Bioscience
See all sources

Compounds related to Adult Acute Lymphocytic Leukemia according to GeneCards/GeneDecks:

(show top 50)    (show all 67)
idCompoundScoreTop Affiliating Genes
1ch2h4folate4410.2MTHFR, TYMS
2methyl-group4410.2MTR, MTHFR
3pemetrexed49 1111.1TYMS, MTHFR
4adenosylcobalamin44 2411.1MTHFR, MTR
55,10-methenyltetrahydrofolate4410.1MTHFR, MTR
6methylcobalamin44 2411.1MTHFR, MTR
7edatrexate4410.0CSF3, TYMS
8cyanocobalamin49 11 2412.0MTR, MTHFR
9Tetrahydrofolic acid11 2411.0SHMT1, MTHFR, MTR
10ara-ctp4410.0TYMS, CSF3
1110-formyltetrahydrofolate4410.0MTR, MTHFR
12thiopurine449.9ABCG2, MTHFR, TYMS
13hydroxocobalamin44 1110.9MTHFR, MTR
14fluorouracil49 1110.9MTHFR, TYMS, ABCG2
15vitamin b12449.9TYMS, MTHFR, MTR
16oxaliplatin44 49 1111.9TYMS, MTHFR, ABCG2
175-aza-2deoxycytidine449.8CDKN1C, CDX1, CDKN2B, CDX2
185-methyltetrahydrofolate44 1110.8MTHFR, MTR
199-aminocamptothecin449.8ABCG2, TYMS, CSF3
20b vitamins449.8TYMS, MTHFR, SHMT1, MTR
21tetrahydrofolate449.8MTHFR, MTR, SHMT1, TYMS
22vitamin b6449.8MTHFR, MTR, TYMS, SHMT1
23pyridoxal 5-phosphate449.8MTHFR, SHMT1, TYMS, MTR
24vinorelbine44 1110.8ABCG2, CSF3, TYMS
25purine44 2410.7SHMT1, MTR, MTHFR, TYMS
26thymidylate449.7MTHFR, TYMS, SHMT1, MTR
27topotecan44 1110.7ABCG2, CSF3, TYMS
28leucovorin44 49 1111.7MTHFR, TYMS, CSF3
296 mercaptopurine449.6MTHFR, CSF3, ABCG2
30zidovudine44 1110.6CSF3, TYMS, ABCG2
31methionine449.5MTHFR, MTR, MME, SHMT1
32taxane449.4ABCG2, MTHFR, TYMS, CSF3
33adriamycin449.4MME, TYMS, CSF3, ABCG2
34folate449.4SHMT1, TYMS, ABCG2, MTHFR, MTR
35irinotecan44 49 1111.4CSF3, TYMS, MTHFR, ABCG2
36carboplatin44 49 1111.4CSF3, MTHFR, TYMS, ABCG2
37gemcitabine44 49 1111.4MTHFR, ABCG2, TYMS, CSF3
38valine449.4CSF3, MTHFR, MTR, TYMS
395fluorouracil449.3ABCG2, CSF3, TYMS, MTHFR
404-hydroperoxycyclophosphamide449.3CD34, CSF3
41hydroxyurea44 49 1111.3CSF3, ABCG2, TYMS
42cytarabine44 49 1111.3MME, TYMS, ABCG2, CSF3, CDKN2B
43dihydrofolate449.2MTHFR, MTR, SHMT1, TYMS, CDKN2B, ABCG2
44mitomycin c449.1ABCG2, TYMS, CSF3
45doxorubicin44 49 1111.0CSF3, TYMS, ABCG2, MME
46cisplatin44 49 59 1112.0TYMS, ABCG2, MTR, MTHFR, CSF3
47methotrexate44 49 1110.7ABCG2, CDKN2B, SHMT1, MTR, TYMS, MTHFR
48thymidine44 249.3MME, CSF3, MTHFR, TYMS, CDX2, CD34
49retinoic acid44 249.3CSF3, MTHFR, MME, CD34, CDKN2B, CDX1
50tyrosine447.4ABCG2, MME, CDX2, CDKN2B, TOM1, CSF3

GO Terms for genes affiliated with Adult Acute Lymphocytic Leukemia

About this section
Sources:
16Gene Ontology
See all sources

Biological processes related to Adult Acute Lymphocytic Leukemia according to GeneCards/GeneDecks:

(show all 9)
idNameGO IDScoreTop Affiliating Genes
1tetrahydrofolate interconversionGO:03599910.1SHMT1, MTHFR
2folic acid metabolic processGO:04665510.0SHMT1, MTHFR
3positive regulation of transforming growth factor beta receptor signaling pathwayGO:03051110.0CDKN1C, CDKN2B
4labyrinthine layer developmentGO:0607119.9CDX4, CDX2
5water-soluble vitamin metabolic processGO:0067679.7MTHFR, MTR, SHMT1
6negative regulation of phosphorylationGO:0423269.7CDKN1C, CDKN2B
7vitamin metabolic processGO:0067669.6MTHFR, MTR, SHMT1
8cellular response to cytokine stimulusGO:0713459.5CSF3, MME
9anterior/posterior pattern specificationGO:0099529.5CDX4, CDX2, CDX1

Molecular functions related to Adult Acute Lymphocytic Leukemia according to GeneCards/GeneDecks:

idNameGO IDScoreTop Affiliating Genes
1cyclin-dependent protein serine/threonine kinase inhibitor activityGO:00486110.0CDKN1C, CDKN2B
2transcription regulatory region sequence-specific DNA bindingGO:0009768.9DLX4, CDX4, CDX2

Products for genes affiliated with Adult Acute Lymphocytic Leukemia

About this section
  • Antibodies
  • Proteins
  • Lysates
  • Antibodies

Sources for Adult Acute Lymphocytic Leukemia

About this section
3CDC
13ExPASy
14FMA
22GTR
23HGMD
24HMDB
25ICD10
26ICD10 via Orphanet
27ICD9CM
28IUPHAR
29KEGG
34MeSH
35MESH via Orphanet
36MGI
39NCIt
40NDF-RT
43NINDS
44Novoseek
46OMIM
47OMIM via Orphanet
50PubMed
51QIAGEN
57SNOMED-CT via Orphanet
60UMLS
61UMLS via Orphanet