MCID: ADL052
MIFTS: 47

Adult Acute Lymphocytic Leukemia

Categories: Blood diseases, Rare diseases, Cancer diseases, Immune diseases

Aliases & Classifications for Adult Acute Lymphocytic Leukemia

MalaCards integrated aliases for Adult Acute Lymphocytic Leukemia:

Name: Adult Acute Lymphocytic Leukemia 37 12 51 14 69
Adult Acute Lymphoid Leukemia 12

Classifications:



External Ids:

Disease Ontology 12 DOID:5604
NCIt 46 C4967
UMLS 69 C0751606

Summaries for Adult Acute Lymphocytic Leukemia

MalaCards based summary : Adult Acute Lymphocytic Leukemia, also known as adult acute lymphoid leukemia, is related to acute lymphocytic leukemia and b-cell adult acute lymphocytic leukemia. An important gene associated with Adult Acute Lymphocytic Leukemia is SHMT1 (Serine Hydroxymethyltransferase 1), and among its related pathways/superpathways are Mitotic G1-G1/S phases and DNA Damage. The drugs Marqibo and Cyclophosphamide have been mentioned in the context of this disorder. Affiliated tissues include Blood and Blood, and related phenotype is neoplasm.

Related Diseases for Adult Acute Lymphocytic Leukemia

Graphical network of the top 20 diseases related to Adult Acute Lymphocytic Leukemia:



Diseases related to Adult Acute Lymphocytic Leukemia

Symptoms & Phenotypes for Adult Acute Lymphocytic Leukemia

MGI Mouse Phenotypes related to Adult Acute Lymphocytic Leukemia:

43
# Description MGI Source Accession Score Top Affiliating Genes
1 neoplasm MP:0002006 8.92 CDKN2B CDX2 SHMT1 TP73

Drugs & Therapeutics for Adult Acute Lymphocytic Leukemia

FDA approved drugs:

# Drug Name Active Ingredient(s) 17 Company Approval Date
1
Marqibo 17 45 VINCRISTINE SULFATE Talon Therapeutics August 2012

Drugs for Adult Acute Lymphocytic Leukemia (from DrugBank, HMDB, Dgidb, PharmGKB, IUPHAR, NovoSeek, BitterDB):

(show top 50) (show all 416)
# Name Status Phase Clinical Trials Cas Number PubChem Id
1
Cyclophosphamide Approved, Investigational Phase 4,Phase 3,Phase 2,Phase 1,Early Phase 1 50-18-0, 6055-19-2 2907
2
Etoposide Approved Phase 4,Phase 3,Phase 2,Phase 1 33419-42-0 36462
3
Idarubicin Approved Phase 4,Phase 3,Phase 2,Phase 1 58957-92-9 42890
4
Asparaginase Approved, Investigational Phase 4,Phase 3,Phase 2,Phase 1 9015-68-3
5
Cladribine Approved, Investigational Phase 4,Phase 2,Phase 1 4291-63-8 20279
6
Cytarabine Approved, Investigational Phase 4,Phase 2,Phase 3,Phase 1,Early Phase 1 147-94-4 6253
7
Daunorubicin Approved Phase 4,Phase 3,Phase 2,Phase 1 20830-81-3 30323
8
Dexamethasone Approved, Investigational, Vet_approved Phase 4,Phase 2,Phase 3,Phase 1,Early Phase 1 50-02-2 5743
9
Doxorubicin Approved, Investigational Phase 4,Phase 3,Phase 2,Phase 1,Early Phase 1 23214-92-8 31703
10
Fludarabine Approved Phase 4,Phase 3,Phase 2,Phase 1 21679-14-1, 75607-67-9 30751
11
Methotrexate Approved Phase 4,Phase 3,Phase 2,Phase 1,Early Phase 1 1959-05-2, 59-05-2 126941
12
Methylprednisolone Approved, Vet_approved Phase 4,Phase 3,Phase 2,Phase 1 83-43-2 6741
13
Prednisolone Approved, Vet_approved Phase 4,Phase 3,Phase 2,Phase 1 50-24-8 5755
14
Teniposide Approved Phase 4,Phase 2 29767-20-2 34698
15
Thioguanine Approved Phase 4,Phase 3,Phase 2 154-42-7 2723601
16
Vincristine Approved, Investigational Phase 4,Phase 3,Phase 2,Phase 1,Early Phase 1 2068-78-2, 57-22-7 5978
17
Vindesine Approved, Investigational Phase 4,Phase 3,Phase 2 53643-48-4, 59917-39-4 40839
18
Lenograstim Approved, Investigational Phase 4,Phase 2,Phase 3,Phase 1 135968-09-1
19
rituximab Approved Phase 4,Phase 3,Phase 2,Phase 1,Early Phase 1 174722-31-7 10201696
20
Prednisone Approved, Vet_approved Phase 4,Phase 3,Phase 2,Phase 1 53-03-2 5865
21
Ifosfamide Approved Phase 4,Phase 2,Phase 3,Phase 1 3778-73-2 3690
22
Mitoxantrone Approved, Investigational Phase 4,Phase 3,Phase 2,Phase 1 65271-80-9 4212
23 Thiotepa Approved, Investigational Phase 4,Phase 3,Phase 2,Phase 1 52-24-4 5453
24
Hydrocortisone Approved, Vet_approved Phase 4,Phase 3,Phase 2,Phase 1 50-23-7 657311 5754
25
Folic Acid Approved, Nutraceutical, Vet_approved Phase 4,Phase 3,Phase 2,Phase 1,Early Phase 1 59-30-3 6037
26
leucovorin Approved, Nutraceutical Phase 4,Phase 3,Phase 2,Phase 1,Early Phase 1 58-05-9 143 6006
27
Doxil Approved June 1999 Phase 4,Phase 3,Phase 2,Phase 1,Early Phase 1 31703
28
Butyric Acid Experimental, Investigational Phase 4,Phase 3,Phase 2,Phase 1 107-92-6 264
29 Alkylating Agents Phase 4,Phase 3,Phase 2,Phase 1,Early Phase 1
30 Anti-Bacterial Agents Phase 4,Phase 3,Phase 2,Phase 1,Early Phase 1
31 Antibiotics, Antitubercular Phase 4,Phase 3,Phase 2,Phase 1,Early Phase 1
32 Antineoplastic Agents, Phytogenic Phase 4,Phase 3,Phase 2,Phase 1,Early Phase 1
33 Antirheumatic Agents Phase 4,Phase 3,Phase 2,Phase 1,Early Phase 1
34 Etoposide phosphate Phase 4,Phase 3,Phase 2,Phase 1
35 Immunosuppressive Agents Phase 4,Phase 3,Phase 2,Phase 1,Early Phase 1
36 Topoisomerase Inhibitors Phase 4,Phase 3,Phase 2,Phase 1,Early Phase 1
37 6-Mercaptopurine Phase 4,Phase 3,Phase 2,Phase 1
38 Antiemetics Phase 4,Phase 2,Phase 3,Phase 1
39 Anti-Infective Agents Phase 4,Phase 3,Phase 2,Phase 1,Early Phase 1
40 Anti-Inflammatory Agents Phase 4,Phase 2,Phase 3,Phase 1
41 Antimetabolites Phase 4,Phase 3,Phase 2,Phase 1
42 Antimetabolites, Antineoplastic Phase 4,Phase 3,Phase 2,Phase 1
43 Antimitotic Agents Phase 4,Phase 3,Phase 2,Phase 1,Early Phase 1
44 Antineoplastic Agents, Hormonal Phase 4,Phase 2,Phase 3,Phase 1
45 Antiviral Agents Phase 4,Phase 3,Phase 2,Phase 1
46 Autonomic Agents Phase 4,Phase 2,Phase 3,Phase 1
47 BB 1101 Phase 4,Phase 2,Phase 3,Phase 1,Early Phase 1
48 Dermatologic Agents Phase 4,Phase 3,Phase 2,Phase 1
49 Dexamethasone acetate Phase 4,Phase 2,Phase 3,Phase 1,Early Phase 1 1177-87-3
50 Folic Acid Antagonists Phase 4,Phase 3,Phase 2,Phase 1,Early Phase 1

Interventional clinical trials:

(show top 50) (show all 577)

# Name Status NCT ID Phase Drugs
1 HD-Idarubicin/Etoposide Intensified Conditioning Regimen Allo-HSCT for Adult ALL Unknown status NCT01873807 Phase 4 IDA;CTX;VP-16
2 German Multicenter Trial for Treatment of Newly Diagnosed Acute Lymphoblastic Leukemia in Adults (07/2003) Unknown status NCT00198991 Phase 4 Cyclophosphamide;Dexamethasone;Vincristine;daunorubicin;Asparaginase;Methotrexate;Cytarabine;Mercaptopurine;G-CSF;Vindesine;VP16;Prednisolone;Adriamycin;Thioguanine;VM26;Idarubicin;Fludarabine;Cladribine
3 German Multicenter Trial for Treatment of Elderly Patients With Newly Diagnosed Acute Lymphoblastic Leukemia Unknown status NCT00198978 Phase 4 Cyclophosphamide;Dexamethasone / Prednisolone;Cytarabine;Idarubicin;Granulocyte-Colony-Stimulating Factor;Mercaptopurine;Methotrexate;Rituximab;HDARAC;Vincristine;Depocyte;Asparaginase
4 Rituximab Plus Chemotherapy for CD20+ Adult Acute Lymphoblastic Leukemia Completed NCT01358253 Phase 4 Cyclophosphamide;Doxorubicin;Vincristine;Dexamethasone;Cytarabine;Methotrexate;Rituximab;6-Mercaptopurine;Prednisone;L-asparaginase
5 Treatment of Elderly Patients (>65 Years) With Acute Lymphoblastic Leukemia Completed NCT00199095 Phase 4 Adriamycin;Cyclophosphamide;Cytarabine;Dexamethasone;Idarubicin;Ifosfamide;Methotrexate;Mercaptopurine;VM26;Vincristine
6 German Multicenter Trial for Treatment of Newly Diagnosed Acute Lymphoblastic Leukemia in Adults (05/93) Completed NCT00199069 Phase 4 Asparaginase;Vincristine;Daunorubicin, Adriamycin;Cyclophosphamide;Ifosfamide;Cytarabine;Mitoxantrone;Methotrexate;6-Mercaptopurine;6-Thioguanine;VM26;Dexamethasone / Prednisolone
7 German Multicenter Trial for Treatment of Newly Diagnosed Acute Lymphoblastic Leukemia in Adults (06/99) Completed NCT00199056 Phase 4 Dexamethasone / Prednisolone;Cyclophosphamide;Methotrexate;Vincristine / Vindesine;Daunorubicin;Asparaginase;G-CSF;Cytarabine;6-Mercaptopurine;VP16;Adriamycin;Thioguanine;VM26;Idarubicin;Fludarabine;Ifosfamide
8 Trial for Treatment of Adult Patients With Standard Risk Acute Lymphoblastic Leukemia With Chemotherapy and Rituximab Completed NCT00199004 Phase 4 Cyclophosphamide;Dexamethasone / Prednisolone;Vincristine;Daunorubicin;Asparaginase;Methotrexate;Cytarabine;Mercaptopurine;G-CSF;Vindesine;VP16;Adriamycin;Thioguanine;VM26;Rituximab
9 Bone Marrow Transplantation in Treating Patients With Hematologic Cancer Completed NCT00003398 Phase 4 cyclophosphamide;thiotepa
10 Treatment of High Risk Adult Acute Lymphoblastic Leukemia Active, not recruiting NCT00853008 Phase 4 Vincristine;Daunorubicin;Prednisone;Mitoxantrone;Cytosine Arabinoside;Dexamethasone;Methotrexate (MTX);Cytarabine;ASP;Mercaptopurine;Teniposide;Hydrocortisone
11 Phase III Study of Vincristine Sulfate Liposome For Injection In Adults With Naïve Acute Lymphoblastic Leukemia Unknown status NCT02072785 Phase 3 Vincristine Sulfate Liposome;Vincristine Sulfate
12 Treatment of Acute Lymphoblastic Leukemia or Aggressive Lymphoma With Relapse in Central Nervous System With Depocyt Unknown status NCT00199108 Phase 2, Phase 3 Depocyt;Dexamethasone
13 High-Dose Methotrexate (MTX) for Adult Acute Lymphoblastic Leukemia (ALL) Unknown status NCT00131027 Phase 3 Cyclophosphamide;Daunorubicin;Vincristine;Prednisolone;L-asparaginase;Cytarabine;Etoposide;Dexamethasone;Methotrexate;Mercaptopurine;Doxorubicin;Methotrexate
14 Pegylated Liposomal Doxorubicin Versus Daunorubicin to Treat Acute Lymphoblastic Leukemia: Unknown status NCT02070523 Phase 3 VDCLD regimen
15 Standard Chemotherapy With or Without Nelarabine or Rituximab in Treating Patients With Newly Diagnosed Acute Lymphoblastic Leukemia Unknown status NCT01085617 Phase 3 cyclophosphamide;cytarabine;daunorubicin hydrochloride;etoposide;fludarabine phosphate;imatinib mesylate;melphalan;mercaptopurine;methotrexate;nelarabine;pegaspargase;vincristine sulfate
16 Ketamine Hydrochloride and Best Pain Management in Treating Cancer Patients With Neuropathic Pain Unknown status NCT01316744 Phase 3 ketamine hydrochloride
17 Combination Chemotherapy With or Without Idarubicin and Peripheral Stem Cell Transplantation in Treating Patients With Leukemia or Myelodysplastic Syndrome Unknown status NCT00002989 Phase 3 busulfan;cyclophosphamide;idarubicin;melphalan
18 Levofloxacin Compared With Cefepime in Treating Cancer Patients With Fever and Neutropenia Unknown status NCT00020865 Phase 3 cefepime hydrochloride;levofloxacin
19 Intensified Conditioning Regimen With High-Dose-Etoposide for Allo-HSCT for Adult Acute Lymphoblastic Leukemia Completed NCT01457040 Phase 2, Phase 3 TBI+CY+VP-16;FA+TBI+CY+VP-16
20 Intrathecal DepoCyte and Lineage-targeted Minimal Residual Disease-oriented Therapy of Acute Lymphoblastic Leukemia Completed NCT00795756 Phase 2, Phase 3 liposome-encapsulated cytarabine (DepoCyte);Triple intrathecal therapy (TIT)
21 Treatment of Hyperuricemia With Rasburicase in Patients With Acute Lymphoblastic Leukemia or High Grade Lymphoma Completed NCT00199043 Phase 3 Allopurinol;Rasburicase
22 Treatment of Acute Lymphoblastic Leukemia (ALL) in Younger Adults Completed NCT00327678 Phase 3 Rituximab;Imatinib Mesylate
23 Chemotherapy With or Without Bone Marrow Transplantation in Treating Patients With Acute Lymphoblastic Leukemia Completed NCT00002700 Phase 3 asparaginase;cyclophosphamide;cytarabine;daunorubicin hydrochloride;dexamethasone;doxorubicin hydrochloride;leucovorin calcium;mercaptopurine;methotrexate;mitoxantrone hydrochloride;prednisolone;prednisone;therapeutic hydrocortisone;vincristine sulfate
24 Low-Dose Prednisone or Methylprednisolone in Treating Patients With Newly Diagnosed Acute Graft-versus-Host Disease Completed NCT00929695 Phase 3 prednisone;methylprednisolone
25 Stem Cell Transplantation Compared With Standard Chemotherapy in Treating Patients With Acute Lymphoblastic Leukemia in First Remission Completed NCT00002514 Phase 3 asparaginase;cyclophosphamide;cytarabine;daunorubicin hydrochloride;dexamethasone;etoposide;imatinib mesylate;leucovorin calcium;mercaptopurine;methotrexate;prednisone;thioguanine;vincristine sulfate
26 Eculizumab in Treating Patients With Paroxysmal Nocturnal Hemoglobinuria Completed NCT00112983 Phase 3
27 Dasatinib and Combination Chemotherapy in Treating Young Patients With Newly Diagnosed Acute Lymphoblastic Leukemia Completed NCT00720109 Phase 2, Phase 3 Asparaginase;Cyclophosphamide;Cytarabine;Dasatinib;Daunorubicin Hydrochloride;Dexamethasone;Etoposide;Hydrocortisone Sodium Succinate;Ifosfamide;Leucovorin Calcium;Mercaptopurine;Methotrexate;Methylprednisolone;Pegaspargase;Prednisone;Vincristine Sulfate
28 Dexamethasone Compared With Prednisone During Induction Therapy and MTX With or Without Leucovorin During Maintenance Therapy in Treating Patients With Newly Diagnosed High-Risk Acute Lymphoblastic Leukemia Completed NCT00075725 Phase 3 cyclophosphamide;cytarabine;daunorubicin hydrochloride;dexamethasone;doxorubicin hydrochloride;leucovorin calcium;mercaptopurine;methotrexate;pegaspargase;prednisone;thioguanine;vincristine sulfate
29 Internet-Based Program With or Without Telephone-Based Problem-Solving Training in Helping Long-Term Survivors of Hematopoietic Stem Cell Transplant Cope With Late Complications Completed NCT00799461 Phase 3
30 Comparison of Two Combination Chemotherapy Regimens in Treating Adults With Previously Untreated Leukemia or Lymphoma Completed NCT00002766 Phase 3 carmustine;cyclophosphamide;cytarabine;daunorubicin hydrochloride;doxorubicin hydrochloride;etoposide;mercaptopurine;methotrexate;mitoxantrone hydrochloride;pegaspargase;prednisone;vincristine sulfate
31 Personalized Information or Basic Information in Helping Patients Make Decisions About Participating in a Clinical Trial Completed NCT00750009 Phase 3
32 American Ginseng in Treating Patients With Fatigue Caused by Cancer Completed NCT00719563 Phase 3 American ginseng
33 Darbepoetin Alfa With or Without Iron in Treating Anemia Caused By Chemotherapy in Patients With Cancer Completed NCT00661999 Phase 3 sodium ferric gluconate complex in sucrose
34 Fentanyl Sublingual Spray in Treating Patients With Breakthrough Cancer Pain Completed NCT00538850 Phase 3 Fentanyl sublingual spray;Placebo
35 Bone Marrow Transplantation in Treating Patients With Leukemia, Myelodysplasia, or Lymphoblastic Lymphoma Completed NCT00003187 Phase 2, Phase 3 cyclophosphamide;cyclosporine;cytarabine;methotrexate;methylprednisolone
36 St. John's Wort in Relieving Fatigue in Patients Undergoing Chemotherapy or Hormone Therapy for Cancer Completed NCT00005805 Phase 3
37 Dalteparin to Prevent Complications in Cancer Patients Receiving Chemotherapy Through a Catheter Completed NCT00006083 Phase 3 Fragmin
38 Valacyclovir in Preventing Cytomegalovirus Infection in Patients Who Are Undergoing Donor Stem Cell Transplantation Completed NCT00045292 Phase 3 acyclovir;acyclovir sodium;valacyclovir
39 Treatment for Chronic Pain in Patients With Advanced Cancer Completed NCT00003687 Phase 3 dextromethorphan hydrobromide;morphine sulfate
40 Opioid Titration Order Sheet or Standard Care in Treating Patients With Cancer Pain Completed NCT00666211 Phase 3
41 Bone Marrow Transplantation in Treating Patients With Acute Leukemia in First or Second Remission Completed NCT00002534 Phase 3 cyclophosphamide;cytarabine;methylprednisolone;thiotepa
42 Treatment of Bone Marrow to Prevent Graft-Versus-Host Disease in Patients With Acute or Chronic Leukemia Undergoing Bone Marrow Transplantation Completed NCT00004255 Phase 2, Phase 3 cyclophosphamide;fludarabine phosphate;methylprednisolone;tacrolimus
43 Music Therapy or Book Discussion in Improving Quality of Life in Young Patients Undergoing Stem Cell Transplant Completed NCT00305851 Phase 3
44 Laboratory-Treated Donor Bone Marrow in Treating Patients Who Are Undergoing a Donor Bone Marrow Transplant for Hematologic Cancer Completed NCT00265837 Phase 3
45 Ondansetron in Treating Patients With Advanced Cancer and Chronic Nausea and Vomiting Not Caused by Cancer Treatment Completed NCT00006348 Phase 3 ondansetron
46 Prevention of Infection in Patients With Hematologic Cancer and Persistent Fever Caused by a Low White Blood Cell Count Completed NCT00003805 Phase 3 piperacillin sodium;piperacillin-tazobactam;tazobactam sodium;vancomycin
47 Caspofungin Acetate Compared With Amphotericin B Liposomal in Treating Patients With Persistent Fever and Neutropenia Following Cancer Treatment Completed NCT00008359 Phase 3 caspofungin acetate;liposomal amphotericin B
48 Liposomal Amphotericin B in Treating Granulocytopenia and Persistent Unexplained Fever in Cancer Patients Completed NCT00003938 Phase 3 liposomal amphotericin B
49 Combination Chemotherapy in Treating Patients With Non-Hodgkin's Lymphoma or Acute Lymphocytic Leukemia Completed NCT00005977 Phase 3 cyclophosphamide;cytarabine;dexamethasone;doxorubicin hydrochloride;etoposide;ifosfamide;leucovorin calcium;methotrexate;vincristine sulfate
50 Graft-Versus-Host Disease Prevention in Treating Patients Who Are Undergoing Bone Marrow Transplantation Completed NCT00002456 Phase 3 cyclosporine;methotrexate

Search NIH Clinical Center for Adult Acute Lymphocytic Leukemia

Cell-based therapeutics:


LifeMap Discovery
Data from LifeMap, the Embryonic Development and Stem Cells Database
Read about Adult Acute Lymphocytic Leukemia cell therapies at LifeMap Discovery.
Stem-cell-based therapeutic approaches for Adult Acute Lymphocytic Leukemia:
Hematopoietic stem cells for treatment of hematologic malignancies
Peripheral blood stem cells for treatment of hematologic malignancies
Embryonic/Adult Cultured Cells Related to Adult Acute Lymphocytic Leukemia:
Bone marrow-derived hematopoietic stem cells
Peripheral blood-derived hematopoietic stem cells (family)

Genetic Tests for Adult Acute Lymphocytic Leukemia

Anatomical Context for Adult Acute Lymphocytic Leukemia

MalaCards organs/tissues related to Adult Acute Lymphocytic Leukemia:

38
Bone, Bone Marrow, Myeloid, T Cells, B Cells, Kidney, Breast
LifeMap Discovery
Data from LifeMap, the Embryonic Development and Stem Cells Database

Cells/anatomical compartments in embryo or adult related to Adult Acute Lymphocytic Leukemia:
# Tissue Anatomical CompartmentCell Relevance
1 Blood Hematopoietic Bone Marrow Hematopoietic Stem Cells Potential therapeutic candidate
2 Blood Peripheral Blood Mature B-Cells Affected by disease
3 Blood Hematopoietic Bone Marrow Small Pre B-Cells Affected by disease

Publications for Adult Acute Lymphocytic Leukemia

Articles related to Adult Acute Lymphocytic Leukemia:

(show top 50) (show all 64)
# Title Authors Year
1
Efficacy and Safety of Vincristine Sulfate Liposome Injection in the Treatment of Adult Acute Lymphocytic Leukemia. ( 27328933 )
2016
2
Medical history, lifestyle, family history, and occupational risk factors for adult acute lymphocytic leukemia: the InterLymph Non-Hodgkin Lymphoma Subtypes Project. ( 25174033 )
2014
3
Serum peptidome based biomarkers searching for monitoring minimal residual disease in adult acute lymphocytic leukemia. ( 25317080 )
2014
4
The Effect of GVHD on Long-term Outcomes after Peripheral Blood Allogeneic Stem Cell Transplantation from an HLA-identical Sibling in Adult Acute Lymphocytic Leukemia: A Landmark Analysis Approach in Competing Risks. ( 24800032 )
2014
5
[Expression and clinical significance of caudal type homeobox transcription factor-2 in adult acute lymphocytic leukemia]. ( 21518475 )
2011
6
Novel targets for treatment of adult acute lymphocytic leukemia. ( 20680526 )
2010
7
Allogeneic hematopoietic stem cell transplantation for adult acute lymphocytic leukemia. ( 20425427 )
2009
8
[Gene expression of breast cancer resistance protein in adult acute lymphocytic leukemia and its clinical significance]. ( 18315895 )
2008
9
Allogeneic hematopoietic stem cell transplantation in adult acute lymphocytic leukemia: impact of donor source on survival. ( 19041062 )
2008
10
Phase II study of sphingosomal vincristine in patients with recurrent or refractory adult acute lymphocytic leukemia. ( 16331634 )
2006
11
Protein expression of a triad of frequently methylated genes, p73, p57Kip2, and p15, has prognostic value in adult acute lymphocytic leukemia independently of its methylation status. ( 15851765 )
2005
12
Gene expression profiles of B-lineage adult acute lymphocytic leukemia reveal genetic patterns that identify lineage derivation and distinct mechanisms of transformation. ( 16243790 )
2005
13
Long-term follow-up results of hyperfractionated cyclophosphamide, vincristine, doxorubicin, and dexamethasone (Hyper-CVAD), a dose-intensive regimen, in adult acute lymphocytic leukemia. ( 15481055 )
2004
14
Aberrant DNA methylation of p57KIP2 identifies a cell-cycle regulatory pathway with prognostic impact in adult acute lymphocytic leukemia. ( 12586619 )
2003
15
Treatment outcome of adult acute lymphocytic leukemia with VPD(L) regimen: analysis of prognostic factors. ( 12760264 )
2003
16
DNA methylation patterns at relapse in adult acute lymphocytic leukemia. ( 12060634 )
2002
17
Polymorphisms in the thymidylate synthase and serine hydroxymethyltransferase genes and risk of adult acute lymphocytic leukemia. ( 11986237 )
2002
18
DNA methylation of multiple promoter-associated CpG islands in adult acute lymphocytic leukemia. ( 12114423 )
2002
19
Central nervous system involvement in adult acute lymphocytic leukemia. ( 11253605 )
2001
20
Rare adult acute lymphocytic leukemia with CD56 expression in the ECOG experience shows unexpected phenotypic and genotypic heterogeneity. ( 11279625 )
2001
21
High-dose anthracycline induction in adult acute lymphocytic leukemia. ( 11253610 )
2001
22
Adult acute lymphocytic leukemia. Future research directions. ( 11253607 )
2001
23
Induction therapy of adult acute lymphocytic leukemia without the use of vincristine or prednisone. ( 11253603 )
2001
24
Cytogenetic aberrations in adult acute lymphocytic leukemia: optimal technique may influence the results. ( 11454422 )
2001
25
Adult acute lymphocytic leukemia. Introduction and questions related to current programs. ( 11147219 )
2000
26
Insights into the biologic and molecular abnormalities in adult acute lymphocytic leukemia. ( 11147223 )
2000
27
The Medical Research Council trials in adult acute lymphocytic leukemia. ( 11147226 )
2000
28
Adult acute lymphocytic leukemia study testing chemotherapy and autologous and allogeneic transplantation. A follow-up report of the French protocol LALA 87. ( 11147227 )
2000
29
The hyper-CVAD regimen in adult acute lymphocytic leukemia. ( 11147229 )
2000
30
Results of treatment with hyper-CVAD, a dose-intensive regimen, in adult acute lymphocytic leukemia. ( 10653870 )
2000
31
Cytogenetics in adult acute lymphocytic leukemia. ( 11147221 )
2000
32
Familial neurofibromatosis type I and adult acute lymphocytic leukemia. ( 10329933 )
1999
33
Deletions and losses in chromosomes 5 or 7 in adult acute lymphocytic leukemia: incidence, associations and implications. ( 10360374 )
1999
34
Analysis of the BCR-ABL protein in Philadelphia chromosome-positive adult acute lymphocytic leukemia. ( 9305617 )
1997
35
Avascular necrosis of bone after adult acute lymphocytic leukemia treatment with methotrexate, vincristine, L-asparaginase, and dexamethasone (MOAD). ( 8756084 )
1996
36
Growth and biologic properties of karyotypically defined subcategories of adult acute lymphocytic leukemia in mice with severe combined immunodeficiency. ( 7492788 )
1995
37
Myeloid markers in adult acute lymphocytic leukemia. Correlations with patient and disease characteristics and with prognosis. ( 8635059 )
1995
38
Management of adult acute lymphocytic leukemia: present issues and key challenges. ( 8201394 )
1994
39
Philadelphia-chromosome-positive adult acute lymphocytic leukemia: characteristics, treatment results, and prognosis in 41 patients. ( 8030658 )
1994
40
Adult acute lymphocytic leukemia: critical review of current knowledge. ( 8059784 )
1994
41
Long-term follow-up of treatment and potential cure of adult acute lymphocytic leukemia with MOAD: a non-anthracycline containing regimen. ( 8350624 )
1993
42
The role of bone marrow transplantation in adult acute lymphocytic leukemia. ( 8338797 )
1993
43
Prognostic significance of elevated serum beta 2-microglobulin levels in adult acute lymphocytic leukemia. ( 1466355 )
1992
44
Treatment of relapsed or refractory adult acute lymphocytic leukemia. ( 1730121 )
1992
45
Adult acute lymphocytic leukemia: the Eastern Cooperative Oncology Group experience. ( 1578927 )
1992
46
Improved results of an intensified therapy in adult acute lymphocytic leukemia. ( 2009234 )
1991
47
The effects of postinduction intensification treatment with cytarabine and daunorubicin in adult acute lymphocytic leukemia: a prospective randomized clinical trial by Cancer and Leukemia Group B. ( 1941059 )
1991
48
Evaluation of cytogenetic samples and pertinent technical variables in adult acute lymphocytic leukemia. ( 2009514 )
1991
49
Phase III trial of brief intensive treatment of adult acute lymphocytic leukemia comparing daunorubicin and mitoxantrone: a CALGB Study. ( 2033963 )
1991
50
The importance of cytogenetic studies in adult acute lymphocytic leukemia. ( 2239977 )
1990

Variations for Adult Acute Lymphocytic Leukemia

Expression for Adult Acute Lymphocytic Leukemia

Search GEO for disease gene expression data for Adult Acute Lymphocytic Leukemia.

Pathways for Adult Acute Lymphocytic Leukemia

GO Terms for Adult Acute Lymphocytic Leukemia

Biological processes related to Adult Acute Lymphocytic Leukemia according to GeneCards Suite gene sharing:

(show all 15)
# Name GO ID Score Top Affiliating Genes
1 anterior/posterior pattern specification GO:0009952 9.55 CDX1 CDX2
2 regulation of mitotic cell cycle GO:0007346 9.54 CDKN1C TP73
3 negative regulation of translation GO:0017148 9.52 SHMT1 TYMS
4 negative regulation of epithelial cell proliferation GO:0050680 9.51 CDKN1C CDKN2B
5 cell cycle arrest GO:0007050 9.5 CDKN1C CDKN2B TP73
6 pattern specification process GO:0007389 9.49 CDX1 CDX2
7 protein tetramerization GO:0051262 9.48 SHMT1 TP73
8 negative regulation of protein serine/threonine kinase activity GO:0071901 9.46 CDKN1C CDKN2B
9 positive regulation of transforming growth factor beta receptor signaling pathway GO:0030511 9.43 CDKN1C CDKN2B
10 negative regulation of phosphorylation GO:0042326 9.4 CDKN1C CDKN2B
11 anterior/posterior axis specification GO:0009948 9.37 CDX1 CDX2
12 tetrahydrofolate interconversion GO:0035999 9.26 SHMT1 TYMS
13 tetrahydrofolate metabolic process GO:0046653 9.16 SHMT1 TYMS
14 regulation of somitogenesis GO:0014807 8.96 CDX1 CDX2
15 dTMP biosynthetic process GO:0006231 8.62 SHMT1 TYMS

Molecular functions related to Adult Acute Lymphocytic Leukemia according to GeneCards Suite gene sharing:

# Name GO ID Score Top Affiliating Genes
1 RNA polymerase II distal enhancer sequence-specific DNA binding GO:0000980 9.16 CDX1 CDX2
2 translation repressor activity, nucleic acid binding GO:0000900 8.96 SHMT1 TYMS
3 cyclin-dependent protein serine/threonine kinase inhibitor activity GO:0004861 8.62 CDKN1C CDKN2B

Sources for Adult Acute Lymphocytic Leukemia

3 CDC
7 CNVD
9 Cosmic
10 dbSNP
11 DGIdb
16 ExPASy
18 FMA
27 GO
28 GTR
29 HGMD
30 HMDB
31 HPO
32 ICD10
33 ICD10 via Orphanet
34 ICD9CM
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36 KEGG
37 LifeMap
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42 MESH via Orphanet
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53 OMIM
54 OMIM via Orphanet
58 PubMed
60 QIAGEN
65 SNOMED-CT via HPO
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67 TGDB
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