MCID: ADL052
MIFTS: 54

Adult Acute Lymphocytic Leukemia malady

Genetic diseases, Cancer diseases, Immune diseases, Rare diseases, Blood diseases categories
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Summaries for Adult Acute Lymphocytic Leukemia

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33MalaCards
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MalaCards: Adult Acute Lymphocytic Leukemia, also known as adult acute lymphoid leukemia, is related to acute lymphocytic leukemia and leukemia. An important gene associated with Adult Acute Lymphocytic Leukemia is SHMT1 (serine hydroxymethyltransferase 1 (soluble)), and among its related pathways are folate polyglutamylation and E2F mediated regulation of DNA replication. The compounds ch2h4folate and 5-Methyltetrahydrofolic acid have been mentioned in the context of this disorder. Affiliated tissues include bone, bone marrow and breast, and related mouse phenotypes are limbs/digits/tail and skeleton.

Aliases & Classifications for Adult Acute Lymphocytic Leukemia

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8Disease Ontology, 10DISEASES, 45Novoseek, 31LifeMap Discovery™, 62UMLS, 40NCIt
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Classifications:



Aliases & Descriptions:

adult acute lymphocytic leukemia 8 10 45 31 62
adult acute lymphoid leukemia 8


External Ids:

Disease Ontology8 DOID:5604
NCIt40 C4967

Related Diseases for Adult Acute Lymphocytic Leukemia

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17GeneCards, 18GeneDecks
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Diseases in the Acute Lymphocytic Leukemia family:

adult acute lymphocytic leukemia Chronic Lymphocytic Leukemia
Familial Acute Lymphocytic Leukemia Familial Chronic Lymphocytic Leukemia
Leukemia, Chronic Lymphocytic 4 Leukemia, Chronic Lymphocytic 3
Leukemia, Acute Lymphocytic 1 Leukemia, Chronic Lymphocytic 1
Leukemia, Chronic Lymphocytic 5 Leukemia, Chronic Lymphocytic 2

Diseases related to Adult Acute Lymphocytic Leukemia via text searches within MalaCards or GeneCards/GeneDecks gene sharing:

(show top 50)    (show all 72)
idRelated DiseaseScoreTop Affiliating Genes
1acute lymphocytic leukemia31.3CDKN1C, CD34, ABCG2, CDKN2B, TYMS, MME
2leukemia31.2CSF3, MTR, MME, TYMS, ABCG2, MTHFR
3breast cancer29.8MME, CD34, ABCG2, CSF3, MTR, CDKN1C
4t-cell adult acute lymphocytic leukemia10.4
5hematopoietic stem cell transplantation10.4
6neurofibromatosis10.2
7severe combined immunodeficiency10.2
8macroglossia10.1CDKN1C
9gallbladder cancer10.1CDX2, TYMS
10lymphoma, diffuse large cell10.1CDKN2B, MME
11esophagitis10.1CDX2, CDX1
12leukemia, acute nonlymphocytic10.1TYMS, CD34
13refractory anemia10.1CSF3, CDKN2B
14tubular adenocarcinoma10.1CDX2, MME
15malignant peripheral nerve sheath tumor10.1CDKN2B, CD34
16stomatitis10.1CSF3, TYMS
17gastric adenocarcinoma10.1TYMS, CDX2, CDKN2B
18endometrial carcinoma10.1CDX2, MME
19gastritis10.1CDX2, CD34
20factor vii deficiency10.0TYMS, CSF3
21precursor t-cell acute lymphoblastic leukemia10.0TYMS, CDKN2B, CD34
22leukopenia10.0CSF3, TYMS
23leukemia, acute lymphoblastic 310.0CD34, CDKN2B, MME
24homocysteinemia due to mthfr deficiency10.0MTR, MTHFR
25immunodeficiency with hyper igm type 210.0MTR, TYMS, MME
26pneumonia10.0TYMS, CSF3, MME
27multiple sclerosis10.0MME, MTR
28aplastic anemia10.0CD34, CSF3
29megaloblastic anemia10.0MTHFR, MTR
30homocysteinemia10.0MTHFR, MTR
31methylmalonic acidemia10.0MTHFR, MTR
32neutropenia10.0CSF3, TYMS, CD34
33pancreatic cancer10.0CDX2, TYMS, ABCG2
34vitamin b12 deficiency10.0MTR, MTHFR
35bladder carcinoma10.0TYMS, CDKN2B, CDKN1C, MTR
36leiomyosarcoma10.0CD34, MME
37acute myeloid leukemia, adult10.0CDKN2B, ABCG2, CD34
38homocystinuria10.0MTR, MTHFR
39choriocarcinoma10.0MME, CDKN1C, ABCG2
40myeloid leukemia10.0CSF3, CDKN2B, CD34
41cerebrovascular disease10.0MTR, MTHFR
42retinoblastoma10.0CDKN1C, CDKN2B, ABCG2, TYMS
43thromboembolism10.0MTHFR, MTR
44folic acid deficiency anemia10.0MTR, TYMS, MTHFR
45hyperhomocysteinemia10.0MTR, TYMS, MTHFR
46lung cancer10.0ABCG2, TYMS, CDX2
47spina bifida10.0MTR, MTHFR
48colon cancer10.0CDX2, CDX1, TYMS, ABCG2
49b-cell lymphomas10.0ABCG2, MME, CDKN1C, CDKN2B
50myelodysplastic syndromes10.0CD34, CDKN2B, CSF3, CDKN1C

Graphical network of the top 20 diseases related to Adult Acute Lymphocytic Leukemia:



Diseases related to adult acute lymphocytic leukemia

Symptoms for Adult Acute Lymphocytic Leukemia

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Drugs & Therapeutics for Adult Acute Lymphocytic Leukemia

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Sources:
42NIH Clinical Center, 6ClinicalTrials, 31LifeMap Discovery™, 62UMLS, 41NDF-RT
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Drug clinical trials:

Search ClinicalTrials for Adult Acute Lymphocytic Leukemia

Search NIH Clinical Center for Adult Acute Lymphocytic Leukemia

Cell-based therapeutics:


LifeMap Discovery
The database of embryonic development, stem cell research and regenerative medicine
Read about Adult Acute Lymphocytic Leukemia cell therapies at LifeMap Discovery.

Genetic Tests for Adult Acute Lymphocytic Leukemia

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Anatomical Context for Adult Acute Lymphocytic Leukemia

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31LifeMap Discovery™, 33MalaCards
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MalaCards organs/tissues related to Adult Acute Lymphocytic Leukemia:

33
Bone, Bone marrow, Breast, Testes, Myeloid

LifeMap Discovery
The database of embryonic development, stem cell research and regenerative medicine

Cells/anatomical compartments in embryo or adult related to Adult Acute Lymphocytic Leukemia:
id TissueAnatomical CompartmentCell Relevance
1 BloodHematopoietic Bone MarrowHematopoietic Stem Cells Potential therapeutic candidate
2 BloodPeripheral BloodMature B-Cells Potential therapeutic candidate, affected by disease
3 BloodHematopoietic Bone MarrowSmall Pre B-Cells Potential therapeutic candidate, affected by disease

Animal Models for Adult Acute Lymphocytic Leukemia or affiliated genes

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37MGI
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MGI Mouse Phenotypes related to Adult Acute Lymphocytic Leukemia:

37
idDescriptionMGI Source AccessionScoreTop Affiliating Genes
1MP:00053718.8CDX4, CDKN1C, CDX2, MTHFR
2MP:00053908.2MTHFR, CDX2, CDKN1C, CDX1, CDX4
3MP:00107717.7ABCG2, MME, MTHFR, CSF3, CDKN2B, CD34
4MP:00053977.2ABCG2, CSF3, CDKN1C, CDX1, CDX4, CDKN2B
5MP:00053766.4CD34, ABCG2, SHMT1, MME, MTHFR, MTR

Publications for Adult Acute Lymphocytic Leukemia

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52PubMed
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Articles related to Adult Acute Lymphocytic Leukemia:

(show top 50)    (show all 60)
idTitleAuthorsYear
1
Expression and clinical significance of caudal type homeobox transcription factor-2 in adult acute lymphocytic leukemia]. (21518475)
2011
2
Novel targets for treatment of adult acute lymphocytic leukemia. (20680526)
2010
3
Allogeneic hematopoietic stem cell transplantation for adult acute lymphocytic leukemia. (20425427)
2009
4
Gene expression of breast cancer resistance protein in adult acute lymphocytic leukemia and its clinical significance]. (18315895)
2008
5
Phase II study of sphingosomal vincristine in patients with recurrent or refractory adult acute lymphocytic leukemia. (16331634)
2006
6
Protein expression of a triad of frequently methylated genes, p73, p57Kip2, and p15, has prognostic value in adult acute lymphocytic leukemia independently of its methylation status. (15851765)
2005
7
Long-term follow-up results of hyperfractionated cyclophosphamide, vincristine, doxorubicin, and dexamethasone (Hyper-CVAD), a dose-intensive regimen, in adult acute lymphocytic leukemia. (15481055)
2004
8
Treatment outcome of adult acute lymphocytic leukemia with VPD(L) regimen: analysis of prognostic factors. (12760264)
2003
9
Aberrant DNA methylation of p57KIP2 identifies a cell-cycle regulatory pathway with prognostic impact in adult acute lymphocytic leukemia. (12586619)
2003
10
Polymorphisms in the thymidylate synthase and serine hydroxymethyltransferase genes and risk of adult acute lymphocytic leukemia. (11986237)
2002
11
DNA methylation of multiple promoter-associated CpG islands in adult acute lymphocytic leukemia. (12114423)
2002
12
DNA methylation patterns at relapse in adult acute lymphocytic leukemia. (12060634)
2002
13
Cytogenetic aberrations in adult acute lymphocytic leukemia: optimal technique may influence the results. (11454422)
2001
14
Rare adult acute lymphocytic leukemia with CD56 expression in the ECOG experience shows unexpected phenotypic and genotypic heterogeneity. (11279625)
2001
15
Induction therapy of adult acute lymphocytic leukemia without the use of vincristine or prednisone. (11253603)
2001
16
Central nervous system involvement in adult acute lymphocytic leukemia. (11253605)
2001
17
The hyper-CVAD regimen in adult acute lymphocytic leukemia. (11147229)
2000
18
The Medical Research Council trials in adult acute lymphocytic leukemia. (11147226)
2000
19
Adult acute lymphocytic leukemia study testing chemotherapy and autologous and allogeneic transplantation. A follow-up report of the French protocol LALA 87. (11147227)
2000
20
Cytogenetics in adult acute lymphocytic leukemia. (11147221)
2000
21
Adult acute lymphocytic leukemia. Introduction and questions related to current programs. (11147219)
2000
22
Insights into the biologic and molecular abnormalities in adult acute lymphocytic leukemia. (11147223)
2000
23
Results of treatment with hyper-CVAD, a dose-intensive regimen, in adult acute lymphocytic leukemia. (10653870)
2000
24
Deletions and losses in chromosomes 5 or 7 in adult acute lymphocytic leukemia: incidence, associations and implications. (10360374)
1999
25
Familial neurofibromatosis type I and adult acute lymphocytic leukemia. (10329933)
1999
26
Analysis of the BCR-ABL protein in Philadelphia chromosome-positive adult acute lymphocytic leukemia. (9305617)
1997
27
Avascular necrosis of bone after adult acute lymphocytic leukemia treatment with methotrexate, vincristine, L-asparaginase, and dexamethasone (MOAD). (8756084)
1996
28
Growth and biologic properties of karyotypically defined subcategories of adult acute lymphocytic leukemia in mice with severe combined immunodeficiency. (7492788)
1995
29
Myeloid markers in adult acute lymphocytic leukemia. Correlations with patient and disease characteristics and with prognosis. (8635059)
1995
30
Philadelphia-chromosome-positive adult acute lymphocytic leukemia: characteristics, treatment results, and prognosis in 41 patients. (8030658)
1994
31
Management of adult acute lymphocytic leukemia: present issues and key challenges. (8201394)
1994
32
The role of bone marrow transplantation in adult acute lymphocytic leukemia. (8338797)
1993
33
Prognostic significance of elevated serum beta 2-microglobulin levels in adult acute lymphocytic leukemia. (1466355)
1992
34
Adult acute lymphocytic leukemia: the Eastern Cooperative Oncology Group experience. (1578927)
1992
35
Treatment of relapsed or refractory adult acute lymphocytic leukemia. (1730121)
1992
36
Phase III trial of brief intensive treatment of adult acute lymphocytic leukemia comparing daunorubicin and mitoxantrone: a CALGB Study. (2033963)
1991
37
The effects of postinduction intensification treatment with cytarabine and daunorubicin in adult acute lymphocytic leukemia: a prospective randomized clinical trial by Cancer and Leukemia Group B. (1941059)
1991
38
Evaluation of cytogenetic samples and pertinent technical variables in adult acute lymphocytic leukemia. (2009514)
1991
39
Improved results of an intensified therapy in adult acute lymphocytic leukemia. (2009234)
1991
40
Testicular relapse in adult acute lymphocytic leukemia: a case report and literature review. (2649778)
1989
41
Low-dose cytosine arabinoside as remission induction therapy in refractory adult acute lymphocytic leukemia. (2929641)
1989
42
Phase II evaluation of teniposide and ifosfamide in refractory adult acute lymphocytic leukemia: a Southwest Oncology Group Study. (3475171)
1987
43
Repeated high-dose cyclophosphamide, BCNU and VP-16-213 and autologous bone marrow transplantation in adult acute lymphocytic leukemia in first remission. (6376130)
1984
44
Treatment of adult acute lymphocytic leukemia. (6953291)
1982
45
Moderate dose methotrexate, vincristine, asparaginase, and dexamethasone for treatment of adult acute lymphocytic leukemia. (7034815)
1982
46
Effective multidrug, multimodality consolidation therapy of adult acute lymphocytic leukemia: a preliminary report. (6977407)
1982
47
High-dose methotrexate for the remission induction of refractory adult acute lymphocytic leukemia. (370537)
1978
48
Remission induction in adult acute lymphocytic leukemia. Use of vincristine and prednisone alone. (1067890)
1976
49
Combination chemotherapy of adult acute lymphocytic leukemia. (770047)
1976
50
Results of therapy in adult acute lymphocytic leukemia. (1064827)
1975

Variations for Adult Acute Lymphocytic Leukemia

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Expression for genes affiliated with Adult Acute Lymphocytic Leukemia

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2BioGPS, 15Gene Expression Omnibus DataSets
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Expression patterns in normal tissues for genes affiliated with Adult Acute Lymphocytic Leukemia

Search GEO for disease gene expression data for Adult Acute Lymphocytic Leukemia.

Pathways for genes affiliated with Adult Acute Lymphocytic Leukemia

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50PathCards, 38NCBI BioSystems Database, 55Reactome, 30KEGG, 51PharmGKB, 60Thomson Reuters
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Pathways related to Adult Acute Lymphocytic Leukemia according to GeneCards/GeneDecks:

idSuper pathways (with members indented)ScoreTop Affiliating Genes
1
Show member pathways
Glycine Metabolism38
glycine biosynthesis I38
folate transformations38
9.9SHMT1, MTR
2
Show member pathways
9.7CDKN2B, CDKN1C, TYMS
3
Show member pathways
L-serine degradation38
pentose phosphate pathway (oxidative branch)38
formaldehyde oxidation II (glutathione-dependent)38
9.4MTHFR, MTR, SHMT1
4
Show member pathways
flavin biosynthesis IV (mammalian)38
molybdenum cofactor biosynthesis38
coenzyme A biosynthesis38
thiamin salvage III38
alanine biosynthesis III38
thio-molybdenum cofactor biosynthesis38
biotin-carboxyl carrier protein assembly38
9.4MTR, SHMT1, MTHFR
5
Show member pathways
9.3MTHFR, ABCG2, TYMS
6
Show member pathways
One Carbon Metabolism38
dTMP de novo biosynthesis (mitochondrial)38
tetrahydrofolate salvage from 5,10-methenyltetrahydrofolate38
Trans-sulfuration and one carbon metabolism38
methionine salvage38
Methionine metabolism60
9.1SHMT1, MTR, MTHFR, TYMS
78.8CD34, MME, CSF3

Compounds for genes affiliated with Adult Acute Lymphocytic Leukemia

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45Novoseek, 24HMDB, 51PharmGKB, 11DrugBank, 61Tocris Bioscience
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Compounds related to Adult Acute Lymphocytic Leukemia according to GeneCards/GeneDecks:

(show top 50)    (show all 91)
idCompoundScoreTop Affiliating Genes
1ch2h4folate4510.1TYMS, MTHFR
25-Methyltetrahydrofolic acid2410.0MTHFR, MTR
3methyl-group4510.0MTHFR, MTR
4dactinomycin51 1110.9ABCG2, MTR
55,10-Methylene-THF249.9TYMS, MTHFR, SHMT1
6edatrexate459.9TYMS, CSF3
7pemetrexed51 1110.9TYMS, MTHFR
85,10-methenyltetrahydrofolate459.8MTR, MTHFR
9adenosylcobalamin45 2410.8MTR, MTHFR
10Tetrahydrofolic acid24 1110.8MTHFR, SHMT1, MTR
11methylcobalamin45 2410.8MTR, MTHFR
12thiopurine459.7ABCG2, TYMS, MTHFR
139-aminocamptothecin459.7CSF3, ABCG2, TYMS
145-aza-2deoxycytidine459.7CDX1, CDX2, CDKN1C, CDKN2B
15vitamin b12459.6MTR, TYMS, MTHFR
1610-formyltetrahydrofolate459.6MTHFR, MTR
17vinorelbine45 51 1111.6TYMS, CSF3, ABCG2
18oxaliplatin45 51 1111.6ABCG2, MTHFR, TYMS
19b vitamins459.6TYMS, MTR, MTHFR, SHMT1
20tetrahydrofolate459.6TYMS, MTHFR, MTR, SHMT1
21topotecan45 1110.6ABCG2, TYMS, CSF3
22vitamin b6459.6TYMS, MTR, MTHFR, SHMT1
23pyridoxal 5-phosphate459.6SHMT1, TYMS, MTR, MTHFR
24fluorouracil51 1110.5TYMS, ABCG2, SHMT1, MTHFR
25purine45 2410.5MTHFR, SHMT1, TYMS, MTR
26thymidylate459.5MTR, MTHFR, SHMT1, TYMS
276 mercaptopurine459.5MTHFR, CSF3, ABCG2
28leucovorin45 51 1111.4SHMT1, MTHFR, CSF3, TYMS
29ara-ctp459.4TYMS, CSF3
30zidovudine45 51 1111.3TYMS, CSF3, ABCG2
31methionine459.3MME, MTHFR, SHMT1, MTR
32adriamycin459.3ABCG2, TYMS, MME, CSF3
33hydroxyurea45 51 1111.3TYMS, CSF3, ABCG2
34taxane459.3ABCG2, TYMS, CSF3, MTHFR
35carboplatin45 51 1111.2TYMS, MTHFR, CSF3, ABCG2
36gemcitabine45 51 1111.2MTHFR, CSF3, ABCG2, TYMS
37valine459.2TYMS, MTHFR, MTR, CSF3
38mitomycin c459.2TYMS, CSF3, ABCG2
39folate459.2MTR, TYMS, MTHFR, SHMT1, ABCG2
40cytarabine45 51 1111.1CDKN2B, CSF3, MME, TYMS, ABCG2
415fluorouracil459.1CSF3, ABCG2, MTHFR, TYMS
42cyclophosphamide45 51 1111.1ABCG2, CSF3, MTR, MTHFR
43irinotecan45 51 1111.0CSF3, SHMT1, TYMS, ABCG2, MTHFR
44doxorubicin45 51 1110.9CSF3, MTR, MME, ABCG2, TYMS
45dihydrofolate458.9ABCG2, TYMS, SHMT1, MTHFR, MTR, CDKN2B
46cisplatin45 51 61 1111.8MTHFR, CSF3, MTR, TYMS, ABCG2
47methotrexate51 45 1110.4TYMS, SHMT1, MTHFR, MTR, ABCG2, CDKN2B
48thymidine45 249.2CDX2, TYMS, MME, MTHFR, CSF3, CD34
49retinoic acid45 249.1CSF3, MTHFR, CDX1, MME, CDKN2B, CD34
50estrogen457.9CD34, CDKN2B, CDX2, MTR, MTHFR, MME

GO Terms for genes affiliated with Adult Acute Lymphocytic Leukemia

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16Gene Ontology
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Biological processes related to Adult Acute Lymphocytic Leukemia according to GeneCards/GeneDecks:

(show all 16)
idNameGO IDScoreTop Affiliating Genes
1negative regulation of protein serine/threonine kinase activityGO:07190110.1CDKN1C, CDKN2B
2tetrahydrofolate interconversionGO:03599910.1MTHFR, SHMT1
3positive regulation of transforming growth factor beta receptor signaling pathwayGO:03051110.0CDKN2B, CDKN1C
4folic acid metabolic processGO:04665510.0SHMT1, MTHFR
5negative regulation of phosphorylationGO:04232610.0CDKN2B, CDKN1C
6response to folic acidGO:05159310.0MTHFR, TYMS
7negative regulation of epithelial cell proliferationGO:0506809.9CDKN2B, CDKN1C
8labyrinthine layer developmentGO:0607119.8CDX4, CDX2
9cellular response to cytokine stimulusGO:0713459.8CSF3, MME
10water-soluble vitamin metabolic processGO:0067679.7MTR, MTHFR, SHMT1
11vitamin metabolic processGO:0067669.7MTR, MTHFR, SHMT1
12anterior/posterior pattern specificationGO:0099529.5CDX2, CDX1, CDX4
13blood vessel developmentGO:0015689.4CDX4, CDX2
14negative regulation of neuron deathGO:19012159.4CD34, CSF3
15response to drugGO:0424939.0MTHFR, TYMS, ABCG2
16small molecule metabolic processGO:0442818.7ABCG2, TYMS, SHMT1, MTHFR, MTR

Molecular functions related to Adult Acute Lymphocytic Leukemia according to GeneCards/GeneDecks:

idNameGO IDScoreTop Affiliating Genes
1cyclin-dependent protein serine/threonine kinase inhibitor activityGO:0048619.9CDKN2B, CDKN1C

Products for genes affiliated with Adult Acute Lymphocytic Leukemia

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Sources for Adult Acute Lymphocytic Leukemia

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4CDC
13ExPASy
14FMA
22GTR
23HGMD
24HMDB
25ICD10
26ICD10 via Orphanet
27ICD9CM
29IUPHAR
30KEGG
35MeSH
36MESH via Orphanet
37MGI
40NCIt
41NDF-RT
44NINDS
45Novoseek
47OMIM
48OMIM via Orphanet
52PubMed
53QIAGEN
59SNOMED-CT via Orphanet
62UMLS
63UMLS via Orphanet