MCID: ADL052
MIFTS: 45

Adult Acute Lymphocytic Leukemia malady

Immune category

Summaries for Adult Acute Lymphocytic Leukemia

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33MalaCards
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MalaCards: Adult Acute Lymphocytic Leukemia, also known as adult acute lymphoid leukemia, is related to acute leukemia and acute lymphocytic leukemia. An important gene associated with Adult Acute Lymphocytic Leukemia is SHMT1 (serine hydroxymethyltransferase 1 (soluble)), and among its related pathways are Fluoropyrimidine Pathway, Pharmacodynamics and Mitotic G1-G1/S phases. The compounds ch2h4folate and methyl-group have been mentioned in the context of this disorder. Affiliated tissues include bone marrow, breast and myeloid, and related mouse phenotypes are integument and homeostasis/metabolism.

Aliases & Classifications for Adult Acute Lymphocytic Leukemia

Sources:
8Disease Ontology, 10DISEASES, 45Novoseek, 31LifeMap Discovery™, 61UMLS, 40NCIt
See all sources

Classifications:

Malacards categories (disease lists): (See all malacards categories)
Anatomical: Immune


Aliases & Descriptions:

adult acute lymphocytic leukemia 8 10 45 31 61
adult acute lymphoid leukemia 8


External Ids:

Disease Ontology8 DOID:5604
NCIt40 C4967

Related Diseases for Adult Acute Lymphocytic Leukemia

Sources:
17GeneCards, 18GeneDecks
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Diseases related to Adult Acute Lymphocytic Leukemia via text searches within MalaCards or GeneCards/GeneDecks gene sharing:

(show top 50)    (show all 90)
idRelated DiseaseScoreTop Affiliating Genes
1acute leukemia31.6ABCG2, CDKN2B, CD34, MTHFR, CSF3
2acute lymphocytic leukemia31.5MTHFR, MME, ABCG2, CSF3, CDKN1C, TYMS
3acute myeloid leukemia, adult30.2CDKN2B, ABCG2, CD34
4t-cell adult acute lymphocytic leukemia10.5
5acute t cell leukemia10.3
6adult t-cell leukemia10.3
7t-cell leukemia10.3
8lymphocytic leukemia, acute t-cell10.3
9hematopoietic stem cell transplantation10.3
10neurofibromatosis10.2
11testicular leukemia10.2
12acute myeloid leukemia10.2
13central nervous system leukemia10.2
14familial acute lymphocytic leukemia10.2
15malignant pleural mesothelioma10.0TYMS
16diarrhea10.0TYMS
17hepatoblastoma10.0CDKN1C
18stomach cancer10.0CDX2
19macroglossia10.0CDKN1C
20bile reflux10.0CDX1
21malignant mesothelioma10.0CDKN2B, TYMS
22multiple myeloma10.0CSF3
23vascular disease10.0CD34
24sarcoma10.0CD34
25gallbladder cancer10.0TYMS, CDX2
26esophagitis10.0CDX1, CDX2
27angiosarcoma10.0CD34
28hyperuricemia10.0ABCG2
29cholangiocarcinoma10.0MME, CDX2
30meningioma10.0CDKN2B, CD34
31multiple sclerosis10.0MTR, MME
32osteosarcoma10.0ABCG2, TYMS
33wilms tumor10.0MME, CDKN1C
34lymphoma, diffuse large cell10.0CDKN2B, MME
35migraine10.0MTHFR
36leukemia, acute nonlymphocytic10.0CD34, TYMS
37gastric adenocarcinoma10.0TYMS, CDKN2B, CDX2
38endometrial carcinoma10.0MME, CD34
39eclampsia10.0MTHFR
40myelomeningocele10.0MTHFR
41refractory anemia10.0CSF3, CDKN2B
42anencephaly10.0MTHFR
43glioblastoma multiforme10.0ABCG2, CDKN1C, CDKN2B
44thrombocytopenia10.0CD34, CSF3
45fibrosarcoma10.0ABCG2, CD34
46gastritis10.0CD34, CDX2
47precursor t-cell acute lymphoblastic leukemia10.0CD34, CDKN2B, TYMS
48precursor b-cell acute lymphoblastic leukemia10.0CDKN2B, MME, CD34
49homocystinuria due to mthfr deficiency10.0MTR, MTHFR
50atherosclerosis10.0MTHFR, MTR

Graphical network of the top 20 diseases related to Adult Acute Lymphocytic Leukemia:



Diseases related to adult acute lymphocytic leukemia

Clinical Features for Adult Acute Lymphocytic Leukemia

Drugs & Therapeutics for Adult Acute Lymphocytic Leukemia

Sources:
5CenterWatch, 42NIH Clinical Center, 6ClinicalTrials, 31LifeMap Discovery™, 61UMLS, 41NDF-RT
See all sources

Approved drugs:

Search CenterWatch for Adult Acute Lymphocytic Leukemia

Drug clinical trials:

Search ClinicalTrials for Adult Acute Lymphocytic Leukemia

Search NIH Clinical Center for Adult Acute Lymphocytic Leukemia

Search CenterWatch for Adult Acute Lymphocytic Leukemia

Cell-based therapeutics:


LifeMap Discovery
The database of embryonic development, stem cell research and regenerative medicine
Read about Adult Acute Lymphocytic Leukemia cell therapies at LifeMap Discovery.

Genetic Tests for Adult Acute Lymphocytic Leukemia

Anatomical Context for Adult Acute Lymphocytic Leukemia

Sources:
31LifeMap Discovery™, 33MalaCards
See all sources

MalaCards organs/tissues related to Adult Acute Lymphocytic Leukemia:

33
Bone marrow, Breast, Myeloid, T cells, B lymphoblasts, B cells

LifeMap Discovery
The database of embryonic development, stem cell research and regenerative medicine

Cells/anatomical compartments in embryo or adult related to Adult Acute Lymphocytic Leukemia:
id TissueAnatomical CompartmentCell Relevance
1 BloodHematopoietic Bone MarrowHematopoietic Stem Cells Potential therapeutic candidate
2 BloodPeripheral BloodMature B-Cells Potential therapeutic candidate, affected by disease
3 BloodHematopoietic Bone MarrowSmall Pre B-Cells Potential therapeutic candidate, affected by disease

Animal Models for Adult Acute Lymphocytic Leukemia or affiliated genes

Sources:
37MGI, 28inGenious Targeting Laboratory
See all sources

MGI Mouse Phenotypes related to Adult Acute Lymphocytic Leukemia:

37
idDescriptionMGI Source AccessionScoreTop Affiliating Genes
1MP:00107718.8ABCG2, MME, CD34, CDKN2B
2MP:00053767.7CD34, MTHFR, MTR, SHMT1, CDX2, CDKN1C
3MP:00053977.3ABCG2, CSF3, CDX4, CDKN1C, CD34, CDX1

Publications for Adult Acute Lymphocytic Leukemia

Sources:
51PubMed
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Articles related to Adult Acute Lymphocytic Leukemia:

(show top 50)    (show all 92)
idTitleAuthorsYear
1
Expression and clinical significance of caudal type homeobox transcription factor-2 in adult acute lymphocytic leukemia]. (21518475)
2011
2
Outcome of allogeneic bone marrow transplantation from unrelated donors for adult Philadelphia chromosome-negative acute lymphocytic leukemia in first complete-remission. (20146028)
2010
3
Novel targets for treatment of adult acute lymphocytic leukemia. (20680526)
2010
4
Allogeneic stem cell transplantation for adult Philadelphia chromosome-negative acute lymphocytic leukemia: comparable survival rates but different risk factors between related and unrelated transplantation in first complete remission. (20664060)
2010
5
Defining the course and prognosis of adults with acute lymphocytic leukemia in first salvage after induction failure or short first remission duration. (20737576)
2010
6
Residual DNA methylation at remission is prognostic in adult Philadelphia chromosome-negative acute lymphocytic leukemia. (19109226)
2009
7
Outcome of adults with acute lymphocytic leukemia after second salvage therapy. (18846563)
2008
8
Gene expression of breast cancer resistance protein in adult acute lymphocytic leukemia and its clinical significance]. (18315895)
2008
9
A case report of an adult with severe hyperlipidemia during acute lymphocytic leukemia induction therapy successfully treated with plasmapheresis. (19140851)
2008
10
Allogeneic hematopoietic stem cell transplantation in adult acute lymphocytic leukemia: impact of donor source on survival. (19041062)
2008
11
Long-term follow-up results of hyperfractionated cyclophosphamide, vincristine, doxorubicin, and dexamethasone (Hyper-CVAD), a dose-intensive regimen, in adult acute lymphocytic leukemia. (15481055)
2004
12
Treatment outcome of adult acute lymphocytic leukemia with VPD(L) regimen: analysis of prognostic factors. (12760264)
2003
13
Phase II study of single agent paclitaxel in adult patients with relapsed acute lymphocytic leukemia. (12795536)
2003
14
Polymorphisms in the thymidylate synthase and serine hydroxymethyltransferase genes and risk of adult acute lymphocytic leukemia. (11986237)
2002
15
Cytogenetic aberrations in adult acute lymphocytic leukemia: optimal technique may influence the results. (11454422)
2001
16
Induction therapy of adult acute lymphocytic leukemia without the use of vincristine or prednisone. (11253603)
2001
17
Allogeneic stem cell transplantation for acute lymphocytic leukemia in adults. (11253611)
2001
18
Burkitt's acute lymphocytic leukemia (L3ALL) in adults. (11253608)
2001
19
Adult acute lymphocytic leukemia. Future research directions. (11253607)
2001
20
High-dose anthracycline induction in adult acute lymphocytic leukemia. (11253610)
2001
21
The hyper-CVAD regimen in adult acute lymphocytic leukemia. (11147229)
2000
22
Adult acute lymphocytic leukemia study testing chemotherapy and autologous and allogeneic transplantation. A follow-up report of the French protocol LALA 87. (11147227)
2000
23
Cytogenetics in adult acute lymphocytic leukemia. (11147221)
2000
24
Adult acute lymphocytic leukemia. Introduction and questions related to current programs. (11147219)
2000
25
Deletions and losses in chromosomes 5 or 7 in adult acute lymphocytic leukemia: incidence, associations and implications. (10360374)
1999
26
Hematologic engraftment and reconstitution of immune function post unrelated placental cord blood transplant in an adult with acute lymphocytic leukemia. (9619913)
1998
27
Analysis of the BCR-ABL protein in Philadelphia chromosome-positive adult acute lymphocytic leukemia. (9305617)
1997
28
The role of allogeneic bone marrow transplantation in the treatment of high-risk acute lymphocytic leukemia in adults. (9179276)
1997
29
Acute lymphocytic leukemia in adults: an update. (8140553)
1994
30
Acute lymphocytic leukemia in adults: a retrospective study and analysis of current management options. (7934190)
1994
31
Philadelphia-chromosome-positive adult acute lymphocytic leukemia: characteristics, treatment results, and prognosis in 41 patients. (8030658)
1994
32
Adult and childhood acute lymphocytic leukemia: are they different diseases? (8416287)
1993
33
Prognostic significance of elevated serum beta 2-microglobulin levels in adult acute lymphocytic leukemia. (1466355)
1992
34
Treatment of relapsed or refractory adult acute lymphocytic leukemia. (1730121)
1992
35
Phase III trial of brief intensive treatment of adult acute lymphocytic leukemia comparing daunorubicin and mitoxantrone: a CALGB Study. (2033963)
1991
36
The effects of postinduction intensification treatment with cytarabine and daunorubicin in adult acute lymphocytic leukemia: a prospective randomized clinical trial by Cancer and Leukemia Group B. (1941059)
1991
37
Improved results of an intensified therapy in adult acute lymphocytic leukemia. (2009234)
1991
38
Treatment of relapsed acute lymphocytic leukemia in adults. (2182434)
1990
39
Testicular relapse in adult acute lymphocytic leukemia: a case report and literature review. (2649778)
1989
40
Low-dose cytosine arabinoside as remission induction therapy in refractory adult acute lymphocytic leukemia. (2929641)
1989
41
Experience with vincristine, doxorubicin, and dexamethasone (VAD) chemotherapy in adults with refractory acute lymphocytic leukemia. (2659160)
1989
42
Identification of risk groups for development of central nervous system leukemia in adults with acute lymphocytic leukemia. (3052630)
1988
43
Phase II evaluation of teniposide and ifosfamide in refractory adult acute lymphocytic leukemia: a Southwest Oncology Group Study. (3475171)
1987
44
Repeated high-dose cyclophosphamide, BCNU and VP-16-213 and autologous bone marrow transplantation in adult acute lymphocytic leukemia in first remission. (6376130)
1984
45
Efficacy of daunorubicin in the therapy of adult acute lymphocytic leukemia: a prospective randomized trial by cancer and leukemia group B. (6375760)
1984
46
Moderate dose methotrexate, vincristine, asparaginase, and dexamethasone for treatment of adult acute lymphocytic leukemia. (7034815)
1982
47
Effective multidrug, multimodality consolidation therapy of adult acute lymphocytic leukemia: a preliminary report. (6977407)
1982
48
Remission induction with daunomycin, vincristine, and prednisone in adult acute lymphocytic leukemia. (266674)
1977
49
Remission induction in adult acute lymphocytic leukemia. Use of vincristine and prednisone alone. (1067890)
1976
50
Results of therapy in adult acute lymphocytic leukemia. (1064827)
1975

Genetic Variations for Adult Acute Lymphocytic Leukemia

Expression for genes affiliated with Adult Acute Lymphocytic Leukemia

Sources:
1BioGPS, 15Gene Expression Omnibus DataSets
See all sources
Expression patterns in normal tissues for genes affiliated with Adult Acute Lymphocytic Leukemia

Search GEO for disease gene expression data for Adult Acute Lymphocytic Leukemia.

Pathways for genes affiliated with Adult Acute Lymphocytic Leukemia

Sources:
50PharmGKB, 54Reactome, 38NCBI BioSystems Database, 30KEGG
See all sources

Compounds for genes affiliated with Adult Acute Lymphocytic Leukemia

Sources:
45Novoseek, 50PharmGKB, 11DrugBank, 24HMDB, 60Tocris Bioscience
See all sources

Compounds related to Adult Acute Lymphocytic Leukemia according to GeneCards/GeneDecks:

(show top 50)    (show all 67)
idCompoundScoreTop Affiliating Genes
1ch2h4folate4510.2MTHFR, TYMS
2methyl-group4510.2MTR, MTHFR
3pemetrexed50 1111.1TYMS, MTHFR
4adenosylcobalamin45 2411.1MTHFR, MTR
55,10-methenyltetrahydrofolate4510.1MTHFR, MTR
6methylcobalamin45 2411.1MTHFR, MTR
7edatrexate4510.0CSF3, TYMS
8cyanocobalamin50 11 2412.0MTR, MTHFR
9Tetrahydrofolic acid11 2411.0SHMT1, MTHFR, MTR
10ara-ctp4510.0TYMS, CSF3
1110-formyltetrahydrofolate4510.0MTR, MTHFR
12thiopurine459.9ABCG2, MTHFR, TYMS
13hydroxocobalamin45 1110.9MTHFR, MTR
14fluorouracil50 1110.9MTHFR, TYMS, ABCG2
15vitamin b12459.9TYMS, MTHFR, MTR
16oxaliplatin45 50 1111.9TYMS, MTHFR, ABCG2
175-aza-2deoxycytidine459.8CDKN1C, CDX1, CDKN2B, CDX2
185-methyltetrahydrofolate45 1110.8MTHFR, MTR
199-aminocamptothecin459.8ABCG2, TYMS, CSF3
20b vitamins459.8TYMS, MTHFR, SHMT1, MTR
21tetrahydrofolate459.8MTHFR, MTR, SHMT1, TYMS
22vitamin b6459.8MTHFR, MTR, TYMS, SHMT1
23pyridoxal 5-phosphate459.8MTHFR, SHMT1, TYMS, MTR
24vinorelbine45 1110.8ABCG2, CSF3, TYMS
25purine45 2410.7SHMT1, MTR, MTHFR, TYMS
26thymidylate459.7MTHFR, TYMS, SHMT1, MTR
27topotecan45 1110.7ABCG2, CSF3, TYMS
28leucovorin45 50 1111.7MTHFR, TYMS, CSF3
296 mercaptopurine459.6MTHFR, CSF3, ABCG2
30zidovudine45 1110.6CSF3, TYMS, ABCG2
31methionine459.5MTHFR, MTR, MME, SHMT1
32taxane459.4ABCG2, MTHFR, TYMS, CSF3
33adriamycin459.4MME, TYMS, CSF3, ABCG2
34folate459.4SHMT1, TYMS, ABCG2, MTHFR, MTR
35irinotecan45 50 1111.4CSF3, TYMS, MTHFR, ABCG2
36carboplatin45 50 1111.4CSF3, MTHFR, TYMS, ABCG2
37gemcitabine45 50 1111.4MTHFR, ABCG2, TYMS, CSF3
38valine459.4CSF3, MTHFR, MTR, TYMS
395fluorouracil459.3ABCG2, CSF3, TYMS, MTHFR
404-hydroperoxycyclophosphamide459.3CD34, CSF3
41hydroxyurea45 50 1111.3CSF3, ABCG2, TYMS
42cytarabine45 50 1111.3MME, TYMS, ABCG2, CSF3, CDKN2B
43dihydrofolate459.2MTHFR, MTR, SHMT1, TYMS, CDKN2B, ABCG2
44mitomycin c459.1ABCG2, TYMS, CSF3
45doxorubicin45 50 1111.0CSF3, TYMS, ABCG2, MME
46cisplatin45 50 60 1112.0TYMS, ABCG2, MTR, MTHFR, CSF3
47methotrexate45 50 1110.7ABCG2, CDKN2B, SHMT1, MTR, TYMS, MTHFR
48thymidine45 249.3MME, CSF3, MTHFR, TYMS, CDX2, CD34
49retinoic acid45 249.3CSF3, MTHFR, MME, CD34, CDKN2B, CDX1
50tyrosine457.4ABCG2, MME, CDX2, CDKN2B, TOM1, CSF3

GO Terms for genes affiliated with Adult Acute Lymphocytic Leukemia

Sources:
16Gene Ontology
See all sources

Biological processes related to Adult Acute Lymphocytic Leukemia according to GeneCards/GeneDecks:

(show all 9)
idNameGO IDScoreTop Affiliating Genes
1tetrahydrofolate interconversionGO:03599910.1MTHFR, SHMT1
2folic acid metabolic processGO:04665510.0SHMT1, MTHFR
3positive regulation of transforming growth factor beta receptor signaling pathwayGO:03051110.0CDKN1C, CDKN2B
4labyrinthine layer developmentGO:0607119.9CDX4, CDX2
5water-soluble vitamin metabolic processGO:0067679.7SHMT1, MTR, MTHFR
6negative regulation of phosphorylationGO:0423269.7CDKN2B, CDKN1C
7vitamin metabolic processGO:0067669.6SHMT1, MTHFR, MTR
8cellular response to cytokine stimulusGO:0713459.5MME, CSF3
9anterior/posterior pattern specificationGO:0099529.5CDX2, CDX4, CDX1

Molecular functions related to Adult Acute Lymphocytic Leukemia according to GeneCards/GeneDecks:

idNameGO IDScoreTop Affiliating Genes
1cyclin-dependent protein serine/threonine kinase inhibitor activityGO:00486110.0CDKN1C, CDKN2B
2transcription regulatory region sequence-specific DNA bindingGO:0009768.9DLX4, CDX4, CDX2

Products for genes affiliated with Adult Acute Lymphocytic Leukemia

  • Antibodies
  • Proteins
  • Lysates
  • Antibodies

Sources for Adult Acute Lymphocytic Leukemia

3CDC
13ExPASy
14FMA
22GTR
23HGMD
24HMDB
25ICD10
26ICD10 via Orphanet
27ICD9CM
29IUPHAR
30KEGG
35MeSH
36MESH via Orphanet
37MGI
40NCIt
41NDF-RT
44NINDS
45Novoseek
47OMIM
48OMIM via Orphanet
51PubMed
52QIAGEN
58SNOMED-CT via Orphanet
61UMLS
62UMLS via Orphanet