MCID: ADL052
MIFTS: 46

Adult Acute Lymphocytic Leukemia malady

Genetic diseases, Immune diseases, Rare diseases, Cancer diseases, Blood diseases categories

Summaries for Adult Acute Lymphocytic Leukemia

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MalaCards based summary: Adult Acute Lymphocytic Leukemia, also known as adult acute lymphoid leukemia, is related to leukemia and breast cancer. An important gene associated with Adult Acute Lymphocytic Leukemia is SHMT1 (serine hydroxymethyltransferase 1 (soluble)), and among its related pathways are folate polyglutamylation and E2F mediated regulation of DNA replication. The compounds ch2h4folate and 5-Methyltetrahydrofolic acid have been mentioned in the context of this disorder. Affiliated tissues include bone, bone marrow and b cells, and related mouse phenotypes are limbs/digits/tail and skeleton.

Aliases & Classifications for Adult Acute Lymphocytic Leukemia

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Adult Acute Lymphocytic Leukemia, Aliases & Descriptions:

Name: Adult Acute Lymphocytic Leukemia 30 9 11 43 60
 
Adult Acute Lymphoid Leukemia 9


Classifications:



External Ids:

Disease Ontology9 DOID:5604
NCIt38 C4967

Related Diseases for Adult Acute Lymphocytic Leukemia

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Diseases in the Chronic Lymphocytic Leukemia family:

adult acute lymphocytic leukemia Familial Acute Lymphocytic Leukemia
Familial Chronic Lymphocytic Leukemia

Diseases related to Adult Acute Lymphocytic Leukemia via text searches within MalaCards or GeneCards Suite gene sharing:

(show top 50)    (show all 69)
idRelated DiseaseScoreTop Affiliating Genes
1leukemia29.7ABCG2, TYMS, MME, MTHFR, MTR, CSF3
2breast cancer28.3ABCG2, TYMS, SHMT1, MME, MTHFR, MTR
3macroglossia10.5CDKN1C
4t-cell adult acute lymphocytic leukemia10.5
5hematopoietic stem cell transplantation10.4
6gallbladder cancer10.3CDX2, TYMS
7esophagitis10.3CDX2, CDX1
8refractory anemia10.3CDKN2B, CSF3
9tubular adenocarcinoma10.3MME, CDX2
10malignant peripheral nerve sheath tumor10.3CDKN2B, CD34
11lymphoid leukemia10.3
12gastric adenocarcinoma10.2CDKN2B, CDX2, TYMS
13stomatitis10.2TYMS, CSF3
14endometrial cancer10.2CDX2, MME
15gastritis10.2CD34, CDX2
16hodgkin lymphoma10.2
17severe combined immunodeficiency10.2
18neurofibromatosis10.2
19factor vii deficiency10.2TYMS, CSF3
20precursor t-cell acute lymphoblastic leukemia10.2TYMS, CDKN2B, CD34
21leukopenia10.1TYMS, CSF3
22precursor b-cell acute lymphoblastic leukemia10.1MME, CDKN2B, CD34
23homocysteinemia due to mthfr deficiency10.1MTR, MTHFR
24hiv-110.1TYMS, MME, MTR
25pneumonia10.1TYMS, MME, CSF3
26multiple sclerosis, disease progression, modifier of10.1MTR, MME
27aplastic anemia10.1CD34, CSF3
28megaloblastic anemia10.1MTHFR, MTR
29homocysteinemia10.1MTR, MTHFR
30methylmalonic acidemia10.1MTHFR, MTR
31pancreatic cancer10.1ABCG2, TYMS, CDX2
32neutropenia10.1TYMS, CSF3, CD34
33bladder cancer, somatic10.1TYMS, MTR, CDKN1C, CDKN2B
34vitamin b12 deficiency10.1MTHFR, MTR
35leiomyosarcoma10.1CD34, MME
36acute myeloid leukemia, adult10.0ABCG2, CDKN2B, CD34
37homocystinuria10.0MTHFR, MTR
38choriocarcinoma10.0ABCG2, MME, CDKN1C
39myeloid leukemia10.0CD34, CDKN2B, CSF3
40cerebrovascular disease10.0MTR, MTHFR
41retinoblastoma10.0CDKN2B, CDKN1C, TYMS, ABCG2
42folic acid deficiency anemia10.0TYMS, MTHFR, MTR
43hyperhomocysteinemia10.0MTR, MTHFR, TYMS
44lung cancer10.0ABCG2, TYMS, CDX2
45neural tube defects10.0MTR, MTHFR
46colorectal cancer9.9CDX1, CDX2, TYMS, ABCG2
47b-cell lymphomas9.9CDKN2B, CDKN1C, MME, ABCG2
48myelodysplastic syndrome9.9CSF3, CDKN1C, CDKN2B, CD34
49leukemia, chronic myeloid9.9CSF3, CDKN1C, CDKN2B, CD34
50hematologic cancer9.9CDKN2B, CDKN1C, CSF3, ABCG2

Graphical network of the top 20 diseases related to Adult Acute Lymphocytic Leukemia:



Diseases related to adult acute lymphocytic leukemia

Symptoms for Adult Acute Lymphocytic Leukemia

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Drugs & Therapeutics for Adult Acute Lymphocytic Leukemia

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Drug clinical trials:

Search ClinicalTrials for Adult Acute Lymphocytic Leukemia

Search NIH Clinical Center for Adult Acute Lymphocytic Leukemia

Cell-based therapeutics:


LifeMap Discovery
Data from LifeMap, the Embryonic Development and Stem Cells Database
Read about Adult Acute Lymphocytic Leukemia cell therapies at LifeMap Discovery.

Genetic Tests for Adult Acute Lymphocytic Leukemia

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Anatomical Context for Adult Acute Lymphocytic Leukemia

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MalaCards organs/tissues related to Adult Acute Lymphocytic Leukemia:

31
Bone, Bone marrow, B cells, Breast, Testes, Myeloid

LifeMap Discovery
Data from LifeMap, the Embryonic Development and Stem Cells Database

Cells/anatomical compartments in embryo or adult related to Adult Acute Lymphocytic Leukemia:
id TissueAnatomical CompartmentCell Relevance
1 BloodHematopoietic Bone MarrowHematopoietic Stem Cells Potential therapeutic candidate
2 BloodPeripheral BloodMature B-Cells Potential therapeutic candidate, affected by disease
3 BloodHematopoietic Bone MarrowSmall Pre B-Cells Potential therapeutic candidate, affected by disease

Animal Models for Adult Acute Lymphocytic Leukemia or affiliated genes

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MGI Mouse Phenotypes related to Adult Acute Lymphocytic Leukemia:

35
idDescriptionMGI Source AccessionScoreTop Affiliating Genes
1MP:00053718.8CDX4, CDKN1C, CDX2, MTHFR
2MP:00053908.2MTHFR, CDX2, CDKN1C, CDX1, CDX4
3MP:00107717.7ABCG2, MME, MTHFR, CSF3, CDKN2B, CD34
4MP:00053977.2ABCG2, CSF3, CDKN1C, CDX1, CDX4, CDKN2B
5MP:00053766.4CD34, ABCG2, SHMT1, MME, MTHFR, MTR

Publications for Adult Acute Lymphocytic Leukemia

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Articles related to Adult Acute Lymphocytic Leukemia:

(show top 50)    (show all 63)
idTitleAuthorsYear
1
Medical history, lifestyle, family history, and occupational risk factors for adult acute lymphocytic leukemia: the InterLymph Non-Hodgkin Lymphoma Subtypes Project. (25174033)
2014
2
Serum peptidome based biomarkers searching for monitoring minimal residual disease in adult acute lymphocytic leukemia. (25317080)
2014
3
The Effect of GVHD on Long-term Outcomes after Peripheral Blood Allogeneic Stem Cell Transplantation from an HLA-identical Sibling in Adult Acute Lymphocytic Leukemia: A Landmark Analysis Approach in Competing Risks. (24800032)
2014
4
Expression and clinical significance of caudal type homeobox transcription factor-2 in adult acute lymphocytic leukemia]. (21518475)
2011
5
Novel targets for treatment of adult acute lymphocytic leukemia. (20680526)
2010
6
Allogeneic hematopoietic stem cell transplantation for adult acute lymphocytic leukemia. (20425427)
2009
7
Gene expression of breast cancer resistance protein in adult acute lymphocytic leukemia and its clinical significance]. (18315895)
2008
8
Phase II study of sphingosomal vincristine in patients with recurrent or refractory adult acute lymphocytic leukemia. (16331634)
2006
9
Protein expression of a triad of frequently methylated genes, p73, p57Kip2, and p15, has prognostic value in adult acute lymphocytic leukemia independently of its methylation status. (15851765)
2005
10
Long-term follow-up results of hyperfractionated cyclophosphamide, vincristine, doxorubicin, and dexamethasone (Hyper-CVAD), a dose-intensive regimen, in adult acute lymphocytic leukemia. (15481055)
2004
11
Treatment outcome of adult acute lymphocytic leukemia with VPD(L) regimen: analysis of prognostic factors. (12760264)
2003
12
Aberrant DNA methylation of p57KIP2 identifies a cell-cycle regulatory pathway with prognostic impact in adult acute lymphocytic leukemia. (12586619)
2003
13
Polymorphisms in the thymidylate synthase and serine hydroxymethyltransferase genes and risk of adult acute lymphocytic leukemia. (11986237)
2002
14
DNA methylation of multiple promoter-associated CpG islands in adult acute lymphocytic leukemia. (12114423)
2002
15
DNA methylation patterns at relapse in adult acute lymphocytic leukemia. (12060634)
2002
16
Cytogenetic aberrations in adult acute lymphocytic leukemia: optimal technique may influence the results. (11454422)
2001
17
Rare adult acute lymphocytic leukemia with CD56 expression in the ECOG experience shows unexpected phenotypic and genotypic heterogeneity. (11279625)
2001
18
Induction therapy of adult acute lymphocytic leukemia without the use of vincristine or prednisone. (11253603)
2001
19
The hyper-CVAD regimen in adult acute lymphocytic leukemia. (11147229)
2000
20
The Medical Research Council trials in adult acute lymphocytic leukemia. (11147226)
2000
21
Adult acute lymphocytic leukemia study testing chemotherapy and autologous and allogeneic transplantation. A follow-up report of the French protocol LALA 87. (11147227)
2000
22
Cytogenetics in adult acute lymphocytic leukemia. (11147221)
2000
23
Adult acute lymphocytic leukemia. Introduction and questions related to current programs. (11147219)
2000
24
Insights into the biologic and molecular abnormalities in adult acute lymphocytic leukemia. (11147223)
2000
25
Results of treatment with hyper-CVAD, a dose-intensive regimen, in adult acute lymphocytic leukemia. (10653870)
2000
26
Deletions and losses in chromosomes 5 or 7 in adult acute lymphocytic leukemia: incidence, associations and implications. (10360374)
1999
27
Familial neurofibromatosis type I and adult acute lymphocytic leukemia. (10329933)
1999
28
Analysis of the BCR-ABL protein in Philadelphia chromosome-positive adult acute lymphocytic leukemia. (9305617)
1997
29
Avascular necrosis of bone after adult acute lymphocytic leukemia treatment with methotrexate, vincristine, L-asparaginase, and dexamethasone (MOAD). (8756084)
1996
30
Growth and biologic properties of karyotypically defined subcategories of adult acute lymphocytic leukemia in mice with severe combined immunodeficiency. (7492788)
1995
31
Myeloid markers in adult acute lymphocytic leukemia. Correlations with patient and disease characteristics and with prognosis. (8635059)
1995
32
Philadelphia-chromosome-positive adult acute lymphocytic leukemia: characteristics, treatment results, and prognosis in 41 patients. (8030658)
1994
33
The role of bone marrow transplantation in adult acute lymphocytic leukemia. (8338797)
1993
34
Prognostic significance of elevated serum beta 2-microglobulin levels in adult acute lymphocytic leukemia. (1466355)
1992
35
Adult acute lymphocytic leukemia: the Eastern Cooperative Oncology Group experience. (1578927)
1992
36
Treatment of relapsed or refractory adult acute lymphocytic leukemia. (1730121)
1992
37
Phase III trial of brief intensive treatment of adult acute lymphocytic leukemia comparing daunorubicin and mitoxantrone: a CALGB Study. (2033963)
1991
38
The effects of postinduction intensification treatment with cytarabine and daunorubicin in adult acute lymphocytic leukemia: a prospective randomized clinical trial by Cancer and Leukemia Group B. (1941059)
1991
39
Evaluation of cytogenetic samples and pertinent technical variables in adult acute lymphocytic leukemia. (2009514)
1991
40
Improved results of an intensified therapy in adult acute lymphocytic leukemia. (2009234)
1991
41
Testicular relapse in adult acute lymphocytic leukemia: a case report and literature review. (2649778)
1989
42
Low-dose cytosine arabinoside as remission induction therapy in refractory adult acute lymphocytic leukemia. (2929641)
1989
43
Phase II evaluation of teniposide and ifosfamide in refractory adult acute lymphocytic leukemia: a Southwest Oncology Group Study. (3475171)
1987
44
Repeated high-dose cyclophosphamide, BCNU and VP-16-213 and autologous bone marrow transplantation in adult acute lymphocytic leukemia in first remission. (6376130)
1984
45
Treatment of adult acute lymphocytic leukemia. (6953291)
1982
46
Moderate dose methotrexate, vincristine, asparaginase, and dexamethasone for treatment of adult acute lymphocytic leukemia. (7034815)
1982
47
Effective multidrug, multimodality consolidation therapy of adult acute lymphocytic leukemia: a preliminary report. (6977407)
1982
48
High-dose methotrexate for the remission induction of refractory adult acute lymphocytic leukemia. (370537)
1978
49
Remission induction in adult acute lymphocytic leukemia. Use of vincristine and prednisone alone. (1067890)
1976
50
Combination chemotherapy of adult acute lymphocytic leukemia. (770047)
1976

Variations for Adult Acute Lymphocytic Leukemia

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Expression for genes affiliated with Adult Acute Lymphocytic Leukemia

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Search GEO for disease gene expression data for Adult Acute Lymphocytic Leukemia.

Pathways for genes affiliated with Adult Acute Lymphocytic Leukemia

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Pathways related to Adult Acute Lymphocytic Leukemia according to GeneCards Suite gene sharing:

idSuper pathways (with members indented)ScoreTop Affiliating Genes
1
Show member pathways
Glycine Metabolism36
glycine biosynthesis I36
folate transformations36
9.9MTR, SHMT1
2
Show member pathways
9.7CDKN2B, CDKN1C, TYMS
3
Show member pathways
L-serine degradation36
pentose phosphate pathway (oxidative branch)36
formaldehyde oxidation II (glutathione-dependent)36
9.4SHMT1, MTHFR, MTR
4
Show member pathways
flavin biosynthesis IV (mammalian)36
molybdenum cofactor biosynthesis36
coenzyme A biosynthesis36
thiamin salvage III36
alanine biosynthesis III36
thio-molybdenum cofactor biosynthesis36
biotin-carboxyl carrier protein assembly36
9.4SHMT1, MTHFR, MTR
5
Show member pathways
9.3ABCG2, TYMS, MTHFR
6
Show member pathways
One Carbon Metabolism36
dTMP de novo biosynthesis (mitochondrial)36
tetrahydrofolate salvage from 5,10-methenyltetrahydrofolate36
Trans-sulfuration and one carbon metabolism36
methionine salvage36
Methionine metabolism58
9.1MTR, MTHFR, SHMT1, TYMS
78.8CD34, CSF3, MME

Compounds for genes affiliated with Adult Acute Lymphocytic Leukemia

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Compounds related to Adult Acute Lymphocytic Leukemia according to GeneCards Suite gene sharing:

(show top 50)    (show all 91)
idCompoundScoreTop Affiliating Genes
1ch2h4folate4310.1MTHFR, TYMS
25-Methyltetrahydrofolic acid2410.0MTHFR, MTR
3methyl-group4310.0MTHFR, MTR
4dactinomycin49 1210.9ABCG2, MTR
55,10-Methylene-THF249.9MTHFR, SHMT1, TYMS
6edatrexate439.9TYMS, CSF3
7pemetrexed49 1210.9MTHFR, TYMS
8adenosylcobalamin43 2410.8MTHFR, MTR
95,10-methenyltetrahydrofolate439.8MTHFR, MTR
10Tetrahydrofolic acid24 1210.8SHMT1, MTHFR, MTR
11methylcobalamin43 2410.8MTR, MTHFR
12thiopurine439.7ABCG2, TYMS, MTHFR
139-aminocamptothecin439.7ABCG2, TYMS, CSF3
145-aza-2deoxycytidine439.7CDX2, CDKN1C, CDX1, CDKN2B
15vitamin b12439.6MTR, MTHFR, TYMS
16hydroxocobalamin43 1210.6MTR, MTHFR
17vinorelbine43 49 1211.6ABCG2, TYMS, CSF3
18oxaliplatin43 49 1211.6ABCG2, TYMS, MTHFR
19b vitamins439.6TYMS, SHMT1, MTHFR, MTR
20tetrahydrofolate439.6MTR, MTHFR, SHMT1, TYMS
21topotecan43 1210.6ABCG2, TYMS, CSF3
22vitamin b6439.6MTR, MTHFR, SHMT1, TYMS
23pyridoxal 5-phosphate439.6TYMS, SHMT1, MTHFR, MTR
24fluorouracil49 1210.5ABCG2, TYMS, SHMT1, MTHFR
25purine43 2410.5TYMS, SHMT1, MTHFR, MTR
26thymidylate439.5MTR, MTHFR, SHMT1, TYMS
276 mercaptopurine439.5ABCG2, MTHFR, CSF3
28leucovorin43 49 1211.4TYMS, SHMT1, MTHFR, CSF3
29ara-ctp439.4CSF3, TYMS
30zidovudine43 49 1211.3ABCG2, TYMS, CSF3
31methionine439.3SHMT1, MME, MTHFR, MTR
32adriamycin439.3CSF3, MME, TYMS, ABCG2
33hydroxyurea43 49 1211.3CSF3, TYMS, ABCG2
34taxane439.3CSF3, MTHFR, TYMS, ABCG2
35carboplatin43 49 1211.2CSF3, MTHFR, TYMS, ABCG2
36gemcitabine43 49 1211.2CSF3, MTHFR, TYMS, ABCG2
37valine439.2CSF3, MTR, MTHFR, TYMS
38mitomycin c439.2ABCG2, TYMS, CSF3
39folate439.2MTR, MTHFR, SHMT1, TYMS, ABCG2
40cytarabine43 49 1211.1ABCG2, TYMS, MME, CSF3, CDKN2B
415fluorouracil439.1CSF3, MTHFR, TYMS, ABCG2
42cyclophosphamide43 49 1211.1ABCG2, MTHFR, MTR, CSF3
43irinotecan43 49 1211.0ABCG2, TYMS, SHMT1, MTHFR, CSF3
44doxorubicin43 49 1210.9ABCG2, TYMS, MME, MTR, CSF3
45dihydrofolate438.9CDKN2B, MTR, MTHFR, SHMT1, TYMS, ABCG2
46cisplatin43 49 59 1211.8ABCG2, TYMS, MTHFR, MTR, CSF3
47methotrexate49 43 1210.4ABCG2, TYMS, SHMT1, MTHFR, MTR, CSF3
48thymidine43 249.2TYMS, MME, MTHFR, CSF3, CDX2, CD34
49retinoic acid43 249.1MME, MTHFR, CSF3, CDX1, CDKN2B, CD34
50estrogen437.9ABCG2, MME, MTHFR, MTR, CDX2, CDKN2B

GO Terms for genes affiliated with Adult Acute Lymphocytic Leukemia

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Biological processes related to Adult Acute Lymphocytic Leukemia according to GeneCards Suite gene sharing:

(show all 16)
idNameGO IDScoreTop Affiliating Genes
1negative regulation of protein serine/threonine kinase activityGO:007190110.1CDKN1C, CDKN2B
2tetrahydrofolate interconversionGO:003599910.1MTHFR, SHMT1
3positive regulation of transforming growth factor beta receptor signaling pathwayGO:003051110.0CDKN2B, CDKN1C
4folic acid metabolic processGO:004665510.0SHMT1, MTHFR
5negative regulation of phosphorylationGO:004232610.0CDKN2B, CDKN1C
6response to folic acidGO:005159310.0MTHFR, TYMS
7negative regulation of epithelial cell proliferationGO:00506809.9CDKN2B, CDKN1C
8labyrinthine layer developmentGO:00607119.8CDX4, CDX2
9cellular response to cytokine stimulusGO:00713459.8CSF3, MME
10water-soluble vitamin metabolic processGO:00067679.7MTR, MTHFR, SHMT1
11vitamin metabolic processGO:00067669.7MTR, MTHFR, SHMT1
12anterior/posterior pattern specificationGO:00099529.5CDX2, CDX1, CDX4
13blood vessel developmentGO:00015689.4CDX4, CDX2
14negative regulation of neuron deathGO:019012159.4CD34, CSF3
15response to drugGO:00424939.0MTHFR, TYMS, ABCG2
16small molecule metabolic processGO:00442818.7ABCG2, TYMS, SHMT1, MTHFR, MTR

Molecular functions related to Adult Acute Lymphocytic Leukemia according to GeneCards Suite gene sharing:

idNameGO IDScoreTop Affiliating Genes
1cyclin-dependent protein serine/threonine kinase inhibitor activityGO:00048619.9CDKN2B, CDKN1C

Products for genes affiliated with Adult Acute Lymphocytic Leukemia

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Sources for Adult Acute Lymphocytic Leukemia

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3CDC
13ExPASy
14FMA
22GTR
23HGMD
24HMDB
25ICD10
26ICD10 via Orphanet
27ICD9CM
28IUPHAR
29KEGG
33MeSH
34MESH via Orphanet
35MGI
38NCIt
39NDF-RT
42NINDS
43Novoseek
45OMIM
46OMIM via Orphanet
50PubMed
51QIAGEN
56SNOMED-CT via Orphanet
60UMLS
61UMLS via Orphanet