MCID: ADL052
MIFTS: 44

Adult Acute Lymphocytic Leukemia malady

Categories: Cancer diseases, Immune diseases, Rare diseases, Genetic diseases, Blood diseases

Aliases & Classifications for Adult Acute Lymphocytic Leukemia

Aliases & Descriptions for Adult Acute Lymphocytic Leukemia:

Name: Adult Acute Lymphocytic Leukemia 38 12 52 14 69
Adult Acute Lymphoid Leukemia 12

Classifications:



External Ids:

Disease Ontology 12 DOID:5604
NCIt 47 C4967
UMLS 69 C0751606

Summaries for Adult Acute Lymphocytic Leukemia

MalaCards based summary : Adult Acute Lymphocytic Leukemia, also known as adult acute lymphoid leukemia, is related to b-cell adult acute lymphocytic leukemia and t-cell adult acute lymphocytic leukemia. An important gene associated with Adult Acute Lymphocytic Leukemia is SHMT1 (Serine Hydroxymethyltransferase 1), and among its related pathways/superpathways are Mitotic G1-G1/S phases and Primary Focal Segmental Glomerulosclerosis FSGS. The drugs Marqibo and Asparaginase have been mentioned in the context of this disorder. Affiliated tissues include Blood and Blood.

Related Diseases for Adult Acute Lymphocytic Leukemia

Graphical network of the top 20 diseases related to Adult Acute Lymphocytic Leukemia:



Diseases related to Adult Acute Lymphocytic Leukemia

Symptoms & Phenotypes for Adult Acute Lymphocytic Leukemia

Drugs & Therapeutics for Adult Acute Lymphocytic Leukemia

FDA approved drugs:

id Drug Name Active Ingredient(s) 17 Company Approval Date
1
Marqibo 17 46 VINCRISTINE SULFATE Talon Therapeutics Approved August 2012

Drugs for Adult Acute Lymphocytic Leukemia (from DrugBank, HMDB, Dgidb, PharmGKB, IUPHAR, NovoSeek, BitterDB):

(show top 50) (show all 609)
id Name Status Phase Clinical Trials Cas Number PubChem Id
1
Asparaginase Approved Phase 4,Phase 3,Phase 2,Phase 1 9015-68-3
2
Cladribine Approved, Investigational Phase 4,Phase 2,Phase 1 4291-63-8 20279
3
Cyclophosphamide Approved, Investigational Phase 4,Phase 3,Phase 2,Phase 1,Early Phase 1 50-18-0, 6055-19-2 2907
4
Cytarabine Approved, Investigational Phase 4,Phase 2,Phase 3,Phase 1 147-94-4 6253
5
Daunorubicin Approved Phase 4,Phase 3,Phase 2,Phase 1 20830-81-3 30323
6
Dexamethasone Approved, Investigational, Vet_approved Phase 4,Phase 2,Phase 3,Phase 1,Early Phase 1 50-02-2 5743
7
Doxorubicin Approved, Investigational Phase 4,Phase 3,Phase 2,Phase 1 23214-92-8 31703
8
Etoposide Approved Phase 4,Phase 3,Phase 2,Phase 1,Early Phase 1 33419-42-0 36462
9
Fludarabine Approved Phase 4,Phase 3,Phase 2,Phase 1 21679-14-1, 75607-67-9 30751
10
Idarubicin Approved Phase 4,Phase 3,Phase 2,Phase 1 58957-92-9 42890
11
Methotrexate Approved Phase 4,Phase 3,Phase 2,Phase 1 1959-05-2, 59-05-2 126941
12
Methylprednisolone Approved, Vet_approved Phase 4,Phase 3,Phase 2,Phase 1 83-43-2 6741
13
Prednisolone Approved, Vet_approved Phase 4,Phase 3,Phase 2,Phase 1 50-24-8 5755
14
Teniposide Approved Phase 4,Phase 3,Phase 2 29767-20-2 34698
15
Thioguanine Approved Phase 4,Phase 3,Phase 2,Phase 1 154-42-7 2723601
16
Vincristine Approved, Investigational Phase 4,Phase 3,Phase 2,Phase 1 2068-78-2, 57-22-7 5978
17
Vindesine Approved Phase 4,Phase 3,Phase 2 59917-39-4, 53643-48-4 40839
18
Lenograstim Approved Phase 4,Phase 2,Phase 3,Phase 1,Early Phase 1 135968-09-1
19
rituximab Approved Phase 4,Phase 3,Phase 2,Phase 1 174722-31-7 10201696
20
Ifosfamide Approved Phase 4,Phase 3,Phase 2,Phase 1,Early Phase 1 3778-73-2 3690
21
Prednisone Approved, Vet_approved Phase 4,Phase 2,Phase 3,Phase 1,Early Phase 1 53-03-2 5865
22
Pegaspargase Approved, Investigational Phase 4,Phase 3,Phase 2,Phase 1 130167-69-0
23
Mitoxantrone Approved, Investigational Phase 4,Phase 3,Phase 2,Phase 1 65271-80-9 4212
24
Thiotepa Approved Phase 4,Phase 3,Phase 2,Phase 1 52-24-4 5453
25
Hydrocortisone Approved, Vet_approved Phase 4,Phase 3,Phase 2,Phase 1 50-23-7 5754 657311
26
Busulfan Approved, Investigational Phase 4,Phase 3,Phase 2,Phase 1,Early Phase 1 55-98-1 2478
27
Miconazole Approved, Investigational, Vet_approved Phase 4,Phase 2,Phase 3,Phase 1 22916-47-8 4189
28
Dasatinib Approved, Investigational Phase 4,Phase 2,Phase 3,Phase 1 302962-49-8 3062316
29
Dopamine Approved Phase 4 51-61-6, 62-31-7 681
30
Methylphenidate Approved, Investigational Phase 4 113-45-1 4158
31
Oprelvekin Approved, Investigational Phase 4 145941-26-0
32
Menthol Approved Phase 4 2216-51-5 16666
33
Posaconazole Approved, Investigational, Vet_approved Phase 4 171228-49-2 147912
34
Amphotericin B Approved, Investigational Phase 4,Phase 3 1397-89-3 14956 5280965
35
Micafungin Approved, Investigational Phase 4,Phase 2 235114-32-6 3081921 477468
36
Nicotine Approved Phase 4 54-11-5 942 89594
37
Folic Acid Approved, Nutraceutical, Vet_approved Phase 4,Phase 3,Phase 2,Phase 1,Early Phase 1 59-30-3 6037
38
leucovorin Approved, Nutraceutical Phase 4,Phase 3,Phase 2,Phase 1,Early Phase 1 58-05-9 54575, 6560146 143
39
Doxil Approved June 1999 Phase 4,Phase 3,Phase 2,Phase 1 31703
40
Butyric Acid Experimental Phase 4,Phase 3,Phase 2,Phase 1 107-92-6 264
41 6-Mercaptopurine Phase 4,Phase 3,Phase 2,Phase 1
42 Alkylating Agents Phase 4,Phase 3,Phase 2,Phase 1,Early Phase 1
43 Anti-Bacterial Agents Phase 4,Phase 3,Phase 2,Phase 1
44 Antibiotics, Antitubercular Phase 4,Phase 3,Phase 2,Phase 1
45 Antiemetics Phase 4,Phase 2,Phase 3,Phase 1,Early Phase 1
46 Anti-Infective Agents Phase 4,Phase 3,Phase 2,Phase 1
47 Anti-Inflammatory Agents Phase 4,Phase 2,Phase 3,Phase 1,Early Phase 1
48 Antimetabolites Phase 4,Phase 3,Phase 2,Phase 1
49 Antimetabolites, Antineoplastic Phase 4,Phase 3,Phase 2,Phase 1
50 Antimitotic Agents Phase 4,Phase 3,Phase 2,Phase 1

Interventional clinical trials:

(show top 50) (show all 1642)
id Name Status NCT ID Phase
1 German Multicenter Trial for Treatment of Newly Diagnosed Acute Lymphoblastic Leukemia in Adults (07/2003) Unknown status NCT00198991 Phase 4
2 German Multicenter Trial for Treatment of Elderly Patients With Newly Diagnosed Acute Lymphoblastic Leukemia Unknown status NCT00198978 Phase 4
3 Intensification Therapy of Mature B-ALL, Burkitt and Burkitt Like and Other High Grade Non-Hodgkin's Lymphoma in Adults Unknown status NCT00797810 Phase 4
4 Treatment Protocol of Children With Philadelphia Chromosome Negative High Risk Acute Lymphoblastic Leukemia Unknown status NCT01990807 Phase 4
5 Medical Research Council (MRC) Working Party on Leukaemia in Children UK National Acute Lymphoblastic Leukaemia (ALL) Trial: UKALL 2003 Unknown status NCT00222612 Phase 4
6 Assessment Of Gh-Igf-1 Axis In Children With Chronic Myelogenous Leukemia (CML) In Remission Unknown status NCT01901666 Phase 4
7 Rituximab Plus Chemotherapy for CD20+ Adult Acute Lymphoblastic Leukemia Completed NCT01358253 Phase 4
8 Intensified Conditioning Regimen With High-Dose-Etoposide for Allo-HSCT for Adult Acute Lymphoblastic Leukemia Completed NCT01457040 Phase 4
9 German Multicenter Trial for Treatment of Newly Diagnosed Acute Lymphoblastic Leukemia in Adults (06/99) Completed NCT00199056 Phase 4
10 German Multicenter Trial for Treatment of Newly Diagnosed Acute Lymphoblastic Leukemia in Adults (05/93) Completed NCT00199069 Phase 4
11 Trial for Treatment of Adult Patients With Standard Risk Acute Lymphoblastic Leukemia With Chemotherapy and Rituximab Completed NCT00199004 Phase 4
12 Treatment of Elderly Patients (>65 Years) With Acute Lymphoblastic Leukemia Completed NCT00199095 Phase 4
13 PETHEMA LAL-RI/96: Treatment for Patients With Standard Risk Acute Lymphoblastic Leukemia Completed NCT00494897 Phase 4
14 Bone Marrow Transplantation in Treating Patients With Hematologic Cancer Completed NCT00003398 Phase 4
15 Trial for the Treatment of Newly Diagnosed Mature B-Cell Acute Lymphoblastic Leukemia (B-ALL), Burkitt's Non-Hodgkin's Lymphoma (NHL) and Other High-grade Lymphoma in Adults Completed NCT00199082 Phase 4
16 German Multicenter Trial for the Treatment of Newly Diagnosed T-lymphoblastic Lymphoma in Adults Completed NCT00199017 Phase 4
17 LAL-Ph-2000: Treatment of Acute Lymphoblastic Leukemia Chromosome Philadelphia Positive Completed NCT00526305 Phase 4
18 ALL-REZ BFM 2002: Multi-Center Study for Children With Relapsed Acute Lymphoblastic Leukemia Completed NCT00114348 Phase 4
19 Learning Impairments Among Survivors of Childhood Cancer Completed NCT00576472 Phase 4
20 Effect of rhIL-11 in Patients With Thrombocytopenia for Childhood ALL Completed NCT02314273 Phase 4
21 The Study on the Pharmacokinetics of PEG-rhG-CSF in Children and Adolescents Completed NCT02953730 Phase 4
22 HD-Idarubicin/Etoposide Intensified Conditioning Regimen Allo-HSCT for Adult ALL Recruiting NCT01873807 Phase 4
23 Identification of New Immune Factors Specific of Relapse in Childhood B Lineage Acute Lymphoblastic Leukemia Recruiting NCT02618109 Phase 4
24 Treatment of Acute Lymphoblastic Leukemia HIGH RISK BCR / ABL NEGATIVE IN ADULTS Recruiting NCT01540812 Phase 4
25 Chemotherapy and Imatinib in Young Adults With Acute Lymphoblastic Leukemia Ph (BCR-ABL) POSITIVE Recruiting NCT01491763 Phase 4
26 PETHEMA LAL-07FRAIL: All Treatment In Fragile Patients Ph' Negative Over 55 Years Recruiting NCT01358201 Phase 4
27 Study on Two Different Formulations of 6-mercaptopurine. Tablet Versus Oral Liquid Recruiting NCT01906671 Phase 4
28 Pethema LAL-RI/2008: Treatment for Patients With Standard Risk Acute Lymphoblastic Leukemia Recruiting NCT02036489 Phase 4
29 ATG Could Improve the Outcome Of Hematopoietic Stem Cell Transplant in Patients With Highly Aggressive T Cell Tumors Recruiting NCT02290132 Phase 4
30 Protocol For the Treatment Acute Lymphoblastic Leukemia With Ph 'Negative in Elderly Patients (> 55 Years) Recruiting NCT01366898 Phase 4
31 Vaccinating Children After Chemotherapy Recruiting NCT02447718 Phase 4
32 ALL SCTped FORUM - Pharmacogenomic Study (add-on Study) Recruiting NCT02670564 Phase 4
33 ATG Based Conditioning Regimen in HLA Related HSCT for Aggressive T-cell Tumors Recruiting NCT02938741 Phase 4
34 Treatment of High Risk Adult Acute Lymphoblastic Leukemia Active, not recruiting NCT00853008 Phase 4
35 Posaconazole Versus Micafungin for Prophylaxis Against Invasive Fungal Infections During Neutropenia in Patients Undergoing Chemotherapy for Acute Myelogenous Leukemia, Acute Lymphocytic Leukemia or Myelodysplastic Syndrome Active, not recruiting NCT01200355 Phase 4
36 Low-dose Chemotherapy Combine With Tyrosine Kinase Inhibitor to Treat ph+ Acute Lymphoblastic Leukemia Patients Not yet recruiting NCT02690922 Phase 4
37 G-CSF Alone or Combination With GM-CSF on Prevention and Treatment of Infection in Children With Malignant Tumor Not yet recruiting NCT02933333 Phase 4
38 A Randomized Phase IV Control Trial of Single High Dose Oral Vitamin D3 in Pediatric Patients Undergoing HSCT Not yet recruiting NCT03176849 Phase 4
39 ProphyALL - Study on the Safety of Liposomal Amphotericin B to Prevent Antifungal Infections in Elderly Patients With Acute Lymphoblastic Leukemia Terminated NCT00386997 Phase 4
40 Atomoxetine for Children With Acquired Attentional Disorders Following Completion of Chemotherapy for ALL Terminated NCT00299234 Phase 4
41 Phase III Study of Vincristine Sulfate Liposome For Injection In Adults With Naïve Acute Lymphoblastic Leukemia Unknown status NCT02072785 Phase 3
42 Treatment of Acute Lymphoblastic Leukemia or Aggressive Lymphoma With Relapse in Central Nervous System With Depocyt Unknown status NCT00199108 Phase 2, Phase 3
43 High-Dose Methotrexate (MTX) for Adult Acute Lymphoblastic Leukemia (ALL) Unknown status NCT00131027 Phase 3
44 Pegylated Liposomal Doxorubicin Versus Daunorubicin to Treat Acute Lymphoblastic Leukemia: Unknown status NCT02070523 Phase 3
45 Standard Chemotherapy With or Without Nelarabine or Rituximab in Treating Patients With Newly Diagnosed Acute Lymphoblastic Leukemia Unknown status NCT01085617 Phase 3
46 Levofloxacin Compared With Cefepime in Treating Cancer Patients With Fever and Neutropenia Unknown status NCT00020865 Phase 3
47 Combination Chemotherapy With or Without Idarubicin and Peripheral Stem Cell Transplantation in Treating Patients With Leukemia or Myelodysplastic Syndrome Unknown status NCT00002989 Phase 3
48 Ketamine Hydrochloride and Best Pain Management in Treating Cancer Patients With Neuropathic Pain Unknown status NCT01316744 Phase 3
49 Combination Chemotherapy in Treating Children With Relapsed Acute Lymphocytic Leukemia Unknown status NCT00002499 Phase 2, Phase 3
50 Risk-Adjusted Combination Chemotherapy in Treating Young Patients With Acute Lymphoblastic Leukemia Unknown status NCT00764907 Phase 3

Search NIH Clinical Center for Adult Acute Lymphocytic Leukemia

Cell-based therapeutics:


LifeMap Discovery
Data from LifeMap, the Embryonic Development and Stem Cells Database
Read about Adult Acute Lymphocytic Leukemia cell therapies at LifeMap Discovery.
Stem-cell-based therapeutic approaches for Adult Acute Lymphocytic Leukemia:
Hematopoietic stem cells for treatment of hematologic malignancies
Peripheral blood stem cells for treatment of hematologic malignancies
Embryonic/Adult Cultured Cells Related to Adult Acute Lymphocytic Leukemia:
Bone marrow-derived hematopoietic stem cells
Peripheral blood-derived hematopoietic stem cells (family)

Genetic Tests for Adult Acute Lymphocytic Leukemia

Anatomical Context for Adult Acute Lymphocytic Leukemia

MalaCards organs/tissues related to Adult Acute Lymphocytic Leukemia:

39
Bone, Bone Marrow, B Cells, Testes, Myeloid, Breast
LifeMap Discovery
Data from LifeMap, the Embryonic Development and Stem Cells Database

Cells/anatomical compartments in embryo or adult related to Adult Acute Lymphocytic Leukemia:
id Tissue Anatomical CompartmentCell Relevance
1 Blood Hematopoietic Bone Marrow Hematopoietic Stem Cells Potential therapeutic candidate
2 Blood Peripheral Blood Mature B-Cells Affected by disease
3 Blood Hematopoietic Bone Marrow Small Pre B-Cells Affected by disease

Publications for Adult Acute Lymphocytic Leukemia

Articles related to Adult Acute Lymphocytic Leukemia:

(show top 50) (show all 64)
id Title Authors Year
1
Efficacy and Safety of Vincristine Sulfate Liposome Injection in the Treatment of Adult Acute Lymphocytic Leukemia. ( 27328933 )
2016
2
Medical history, lifestyle, family history, and occupational risk factors for adult acute lymphocytic leukemia: the InterLymph Non-Hodgkin Lymphoma Subtypes Project. ( 25174033 )
2014
3
Serum peptidome based biomarkers searching for monitoring minimal residual disease in adult acute lymphocytic leukemia. ( 25317080 )
2014
4
The Effect of GVHD on Long-term Outcomes after Peripheral Blood Allogeneic Stem Cell Transplantation from an HLA-identical Sibling in Adult Acute Lymphocytic Leukemia: A Landmark Analysis Approach in Competing Risks. ( 24800032 )
2014
5
[Expression and clinical significance of caudal type homeobox transcription factor-2 in adult acute lymphocytic leukemia]. ( 21518475 )
2011
6
Novel targets for treatment of adult acute lymphocytic leukemia. ( 20680526 )
2010
7
Allogeneic hematopoietic stem cell transplantation for adult acute lymphocytic leukemia. ( 20425427 )
2009
8
[Gene expression of breast cancer resistance protein in adult acute lymphocytic leukemia and its clinical significance]. ( 18315895 )
2008
9
Allogeneic hematopoietic stem cell transplantation in adult acute lymphocytic leukemia: impact of donor source on survival. ( 19041062 )
2008
10
Phase II study of sphingosomal vincristine in patients with recurrent or refractory adult acute lymphocytic leukemia. ( 16331634 )
2006
11
Protein expression of a triad of frequently methylated genes, p73, p57Kip2, and p15, has prognostic value in adult acute lymphocytic leukemia independently of its methylation status. ( 15851765 )
2005
12
Gene expression profiles of B-lineage adult acute lymphocytic leukemia reveal genetic patterns that identify lineage derivation and distinct mechanisms of transformation. ( 16243790 )
2005
13
Long-term follow-up results of hyperfractionated cyclophosphamide, vincristine, doxorubicin, and dexamethasone (Hyper-CVAD), a dose-intensive regimen, in adult acute lymphocytic leukemia. ( 15481055 )
2004
14
Treatment outcome of adult acute lymphocytic leukemia with VPD(L) regimen: analysis of prognostic factors. ( 12760264 )
2003
15
Aberrant DNA methylation of p57KIP2 identifies a cell-cycle regulatory pathway with prognostic impact in adult acute lymphocytic leukemia. ( 12586619 )
2003
16
Polymorphisms in the thymidylate synthase and serine hydroxymethyltransferase genes and risk of adult acute lymphocytic leukemia. ( 11986237 )
2002
17
DNA methylation of multiple promoter-associated CpG islands in adult acute lymphocytic leukemia. ( 12114423 )
2002
18
DNA methylation patterns at relapse in adult acute lymphocytic leukemia. ( 12060634 )
2002
19
Rare adult acute lymphocytic leukemia with CD56 expression in the ECOG experience shows unexpected phenotypic and genotypic heterogeneity. ( 11279625 )
2001
20
Induction therapy of adult acute lymphocytic leukemia without the use of vincristine or prednisone. ( 11253603 )
2001
21
Cytogenetic aberrations in adult acute lymphocytic leukemia: optimal technique may influence the results. ( 11454422 )
2001
22
High-dose anthracycline induction in adult acute lymphocytic leukemia. ( 11253610 )
2001
23
Central nervous system involvement in adult acute lymphocytic leukemia. ( 11253605 )
2001
24
Adult acute lymphocytic leukemia. Future research directions. ( 11253607 )
2001
25
The hyper-CVAD regimen in adult acute lymphocytic leukemia. ( 11147229 )
2000
26
The Medical Research Council trials in adult acute lymphocytic leukemia. ( 11147226 )
2000
27
Adult acute lymphocytic leukemia study testing chemotherapy and autologous and allogeneic transplantation. A follow-up report of the French protocol LALA 87. ( 11147227 )
2000
28
Results of treatment with hyper-CVAD, a dose-intensive regimen, in adult acute lymphocytic leukemia. ( 10653870 )
2000
29
Cytogenetics in adult acute lymphocytic leukemia. ( 11147221 )
2000
30
Adult acute lymphocytic leukemia. Introduction and questions related to current programs. ( 11147219 )
2000
31
Insights into the biologic and molecular abnormalities in adult acute lymphocytic leukemia. ( 11147223 )
2000
32
Familial neurofibromatosis type I and adult acute lymphocytic leukemia. ( 10329933 )
1999
33
Deletions and losses in chromosomes 5 or 7 in adult acute lymphocytic leukemia: incidence, associations and implications. ( 10360374 )
1999
34
Analysis of the BCR-ABL protein in Philadelphia chromosome-positive adult acute lymphocytic leukemia. ( 9305617 )
1997
35
Avascular necrosis of bone after adult acute lymphocytic leukemia treatment with methotrexate, vincristine, L-asparaginase, and dexamethasone (MOAD). ( 8756084 )
1996
36
Myeloid markers in adult acute lymphocytic leukemia. Correlations with patient and disease characteristics and with prognosis. ( 8635059 )
1995
37
Growth and biologic properties of karyotypically defined subcategories of adult acute lymphocytic leukemia in mice with severe combined immunodeficiency. ( 7492788 )
1995
38
Adult acute lymphocytic leukemia: critical review of current knowledge. ( 8059784 )
1994
39
Philadelphia-chromosome-positive adult acute lymphocytic leukemia: characteristics, treatment results, and prognosis in 41 patients. ( 8030658 )
1994
40
Management of adult acute lymphocytic leukemia: present issues and key challenges. ( 8201394 )
1994
41
The role of bone marrow transplantation in adult acute lymphocytic leukemia. ( 8338797 )
1993
42
Long-term follow-up of treatment and potential cure of adult acute lymphocytic leukemia with MOAD: a non-anthracycline containing regimen. ( 8350624 )
1993
43
Prognostic significance of elevated serum beta 2-microglobulin levels in adult acute lymphocytic leukemia. ( 1466355 )
1992
44
Treatment of relapsed or refractory adult acute lymphocytic leukemia. ( 1730121 )
1992
45
Adult acute lymphocytic leukemia: the Eastern Cooperative Oncology Group experience. ( 1578927 )
1992
46
Phase III trial of brief intensive treatment of adult acute lymphocytic leukemia comparing daunorubicin and mitoxantrone: a CALGB Study. ( 2033963 )
1991
47
Improved results of an intensified therapy in adult acute lymphocytic leukemia. ( 2009234 )
1991
48
The effects of postinduction intensification treatment with cytarabine and daunorubicin in adult acute lymphocytic leukemia: a prospective randomized clinical trial by Cancer and Leukemia Group B. ( 1941059 )
1991
49
Evaluation of cytogenetic samples and pertinent technical variables in adult acute lymphocytic leukemia. ( 2009514 )
1991
50
The importance of cytogenetic studies in adult acute lymphocytic leukemia. ( 2239977 )
1990

Variations for Adult Acute Lymphocytic Leukemia

Expression for Adult Acute Lymphocytic Leukemia

Search GEO for disease gene expression data for Adult Acute Lymphocytic Leukemia.

Pathways for Adult Acute Lymphocytic Leukemia

GO Terms for Adult Acute Lymphocytic Leukemia

Biological processes related to Adult Acute Lymphocytic Leukemia according to GeneCards Suite gene sharing:

(show all 12)
id Name GO ID Score Top Affiliating Genes
1 negative regulation of translation GO:0017148 9.51 SHMT1 TYMS
2 negative regulation of epithelial cell proliferation GO:0050680 9.49 CDKN1C CDKN2B
3 pattern specification process GO:0007389 9.48 CDX1 CDX2
4 placenta development GO:0001890 9.46 CDKN1C CDX2
5 negative regulation of protein serine/threonine kinase activity GO:0071901 9.43 CDKN1C CDKN2B
6 positive regulation of transforming growth factor beta receptor signaling pathway GO:0030511 9.4 CDKN1C CDKN2B
7 negative regulation of phosphorylation GO:0042326 9.37 CDKN1C CDKN2B
8 anterior/posterior axis specification GO:0009948 9.32 CDX1 CDX2
9 tetrahydrofolate interconversion GO:0035999 9.26 SHMT1 TYMS
10 tetrahydrofolate metabolic process GO:0046653 9.16 SHMT1 TYMS
11 regulation of somitogenesis GO:0014807 8.96 CDX1 CDX2
12 dTMP biosynthetic process GO:0006231 8.62 SHMT1 TYMS

Molecular functions related to Adult Acute Lymphocytic Leukemia according to GeneCards Suite gene sharing:

id Name GO ID Score Top Affiliating Genes
1 RNA polymerase II distal enhancer sequence-specific DNA binding GO:0000980 9.16 CDX1 CDX2
2 translation repressor activity, nucleic acid binding GO:0000900 8.96 SHMT1 TYMS
3 cyclin-dependent protein serine/threonine kinase inhibitor activity GO:0004861 8.62 CDKN1C CDKN2B

Sources for Adult Acute Lymphocytic Leukemia

3 CDC
7 CNVD
9 Cosmic
10 dbSNP
11 DGIdb
16 ExPASy
18 FMA
28 GO
29 GTR
30 HGMD
31 HMDB
32 HPO
33 ICD10
34 ICD10 via Orphanet
35 ICD9CM
36 IUPHAR
37 KEGG
38 LifeMap
40 MedGen
42 MeSH
43 MESH via Orphanet
44 MGI
46 NCI
47 NCIt
48 NDF-RT
51 NINDS
52 Novoseek
54 OMIM
55 OMIM via Orphanet
59 PubMed
60 QIAGEN
65 SNOMED-CT via Orphanet
67 TGDB
68 Tocris
69 UMLS
70 UMLS via Orphanet
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