MCID: ADL052
MIFTS: 49

Adult Acute Lymphocytic Leukemia malady

Immune diseases category

Summaries for Adult Acute Lymphocytic Leukemia

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MalaCards: Adult Acute Lymphocytic Leukemia, also known as adult acute lymphoid leukemia, is related to acute leukemia and acute lymphocytic leukemia. An important gene associated with Adult Acute Lymphocytic Leukemia is SHMT1 (serine hydroxymethyltransferase 1 (soluble)), and among its related pathways are Fluoropyrimidine Pathway, Pharmacodynamics and Mitotic G1-G1/S phases. The compounds ch2h4folate and methyl-group have been mentioned in the context of this disorder. Affiliated tissues include bone, bone marrow and t cells, and related mouse phenotypes are integument and homeostasis/metabolism.

Aliases & Classifications for Adult Acute Lymphocytic Leukemia

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Sources:
8Disease Ontology, 10DISEASES, 44Novoseek, 30LifeMap Discovery™, 60UMLS, 39NCIt
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Classifications:

Malacards categories (disease lists): (See all malacards categories)
Anatomical: Immune diseases


Aliases & Descriptions:

adult acute lymphocytic leukemia 8 10 44 30 60
adult acute lymphoid leukemia 8


External Ids:

Disease Ontology8 DOID:5604
NCIt39 C4967

Related Diseases for Adult Acute Lymphocytic Leukemia

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17GeneCards, 18GeneDecks
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Diseases in the Acute Lymphocytic Leukemia family:

adult acute lymphocytic leukemia Chronic Lymphocytic Leukemia
Familial Acute Lymphocytic Leukemia Familial Chronic Lymphocytic Leukemia
Leukemia, Chronic Lymphocytic 4 Leukemia, Chronic Lymphocytic 3
Leukemia, Acute Lymphocytic 1 Leukemia, Chronic Lymphocytic 1
Leukemia, Chronic Lymphocytic 5 Leukemia, Chronic Lymphocytic 2

Diseases related to Adult Acute Lymphocytic Leukemia via text searches within MalaCards or GeneCards/GeneDecks gene sharing:

(show top 50)    (show all 85)
idRelated DiseaseScoreTop Affiliating Genes
1acute leukemia31.5CSF3, MTHFR, CDKN2B, CD34, ABCG2
2acute lymphocytic leukemia31.5CSF3, MTHFR, TYMS, CDKN2B, CD34, CDKN1C
3leukemia31.5CSF3, MTHFR, MTR, TYMS, CDKN2B, CDX2
4myeloid leukemia30.2CSF3, CDKN2B, CD34
5breast cancer30.2CSF3, MTHFR, MTR, SHMT1, TYMS, CDX2
6t-cell adult acute lymphocytic leukemia10.3
7neurofibromatosis10.2
8testicular leukemia10.2
9acute myeloid leukemia10.2
10central nervous system leukemia10.2
11severe combined immunodeficiency10.2
12malignant pleural mesothelioma10.0TYMS
13diarrhea10.0TYMS
14hepatoblastoma10.0CDKN1C
15stomach cancer10.0CDX2
16macroglossia10.0CDKN1C
17bile reflux10.0CDX1
18malignant mesothelioma10.0CDKN2B, TYMS
19multiple myeloma10.0CSF3
20vascular disease10.0CD34
21sarcoma10.0CD34
22gallbladder cancer10.0CDX2, TYMS
23esophagitis10.0CDX2, CDX1
24angiosarcoma10.0CD34
25hyperuricemia10.0ABCG2
26cholangiocarcinoma10.0MME, CDX2
27meningioma10.0CDKN2B, CD34
28multiple sclerosis10.0MME, MTR
29osteosarcoma10.0TYMS, ABCG2
30wilms tumor10.0MME, CDKN1C
31lymphoma, diffuse large cell10.0MME, CDKN2B
32migraine10.0MTHFR
33leukemia, acute nonlymphocytic10.0TYMS, CD34
34gastric adenocarcinoma10.0CDX2, CDKN2B, TYMS
35endometrial carcinoma10.0MME, CD34
36eclampsia10.0MTHFR
37myelomeningocele10.0MTHFR
38anencephaly10.0MTHFR
39refractory anemia10.0CDKN2B, CSF3
40glioblastoma multiforme10.0CDKN2B, CDKN1C, ABCG2
41thrombocytopenia10.0CD34, CSF3
42fibrosarcoma10.0ABCG2, CD34
43gastritis10.0CDX2, CD34
44precursor t-cell acute lymphoblastic leukemia10.0CD34, CDKN2B, TYMS
45precursor b-cell acute lymphoblastic leukemia10.0MME, CD34, CDKN2B
46homocystinuria due to mthfr deficiency10.0MTR, MTHFR
47atherosclerosis10.0MTR, MTHFR
48bladder carcinoma10.0CDKN1C, CDKN2B, TYMS, MTR
49spina bifida10.0MTHFR, MTR
50alzheimer's disease10.0MME, MTR

Graphical network of the top 20 diseases related to Adult Acute Lymphocytic Leukemia:



Diseases related to adult acute lymphocytic leukemia

Clinical Features for Adult Acute Lymphocytic Leukemia

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Drugs & Therapeutics for Adult Acute Lymphocytic Leukemia

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Sources:
5CenterWatch, 41NIH Clinical Center, 6ClinicalTrials, 30LifeMap Discovery™, 60UMLS, 40NDF-RT
See all sources

Approved drugs:

Search CenterWatch for Adult Acute Lymphocytic Leukemia

Drug clinical trials:

Search ClinicalTrials for Adult Acute Lymphocytic Leukemia

Search NIH Clinical Center for Adult Acute Lymphocytic Leukemia

Search CenterWatch for Adult Acute Lymphocytic Leukemia

Cell-based therapeutics:


LifeMap Discovery
The database of embryonic development, stem cell research and regenerative medicine
Read about Adult Acute Lymphocytic Leukemia cell therapies at LifeMap Discovery.

Genetic Tests for Adult Acute Lymphocytic Leukemia

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Anatomical Context for Adult Acute Lymphocytic Leukemia

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Sources:
30LifeMap Discovery™, 32MalaCards
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MalaCards organs/tissues related to Adult Acute Lymphocytic Leukemia:

32
Bone, Bone marrow, T cells, B cells, Testes, Breast, Myeloid

LifeMap Discovery
The database of embryonic development, stem cell research and regenerative medicine

Cells/anatomical compartments in embryo or adult related to Adult Acute Lymphocytic Leukemia:
id TissueAnatomical CompartmentCell Relevance
1 BloodHematopoietic Bone MarrowHematopoietic Stem Cells Potential therapeutic candidate
2 BloodPeripheral BloodMature B-Cells Potential therapeutic candidate, affected by disease
3 BloodHematopoietic Bone MarrowSmall Pre B-Cells Potential therapeutic candidate, affected by disease

Animal Models for Adult Acute Lymphocytic Leukemia or affiliated genes

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36MGI
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MGI Mouse Phenotypes related to Adult Acute Lymphocytic Leukemia:

36
idDescriptionMGI Source AccessionScoreTop Affiliating Genes
1MP:00107718.8ABCG2, MME, CD34, CDKN2B
2MP:00053767.7CD34, MTHFR, MTR, SHMT1, CDX2, CDKN1C
3MP:00053977.3ABCG2, CSF3, CDX4, CDKN1C, CD34, CDX1

Publications for Adult Acute Lymphocytic Leukemia

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50PubMed
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Articles related to Adult Acute Lymphocytic Leukemia:

(show top 50)    (show all 92)
idTitleAuthorsYear
1
Biology and treatment of acute lymphocytic leukemia in adolescents and young adults. (23714524)
2013
2
Outcome of allogeneic bone marrow transplantation from unrelated donors for adult Philadelphia chromosome-negative acute lymphocytic leukemia in first complete-remission. (20146028)
2010
3
Novel targets for treatment of adult acute lymphocytic leukemia. (20680526)
2010
4
Allogeneic stem cell transplantation for adult Philadelphia chromosome-negative acute lymphocytic leukemia: comparable survival rates but different risk factors between related and unrelated transplantation in first complete remission. (20664060)
2010
5
Defining the course and prognosis of adults with acute lymphocytic leukemia in first salvage after induction failure or short first remission duration. (20737576)
2010
6
Allogeneic hematopoietic stem cell transplantation for adult acute lymphocytic leukemia. (20425427)
2009
7
Outcome of adults with acute lymphocytic leukemia after second salvage therapy. (18846563)
2008
8
Gene expression of breast cancer resistance protein in adult acute lymphocytic leukemia and its clinical significance]. (18315895)
2008
9
Allogeneic hematopoietic stem cell transplantation in adult acute lymphocytic leukemia: impact of donor source on survival. (19041062)
2008
10
How I treat acute lymphocytic leukemia in adults. (17596539)
2007
11
Gene expression profiles of B-lineage adult acute lymphocytic leukemia reveal genetic patterns that identify lineage derivation and distinct mechanisms of transformation. (16243790)
2005
12
Aberrant DNA methylation of p57KIP2 identifies a cell-cycle regulatory pathway with prognostic impact in adult acute lymphocytic leukemia. (12586619)
2003
13
DNA methylation of multiple promoter-associated CpG islands in adult acute lymphocytic leukemia. (12114423)
2002
14
Rare adult acute lymphocytic leukemia with CD56 expression in the ECOG experience shows unexpected phenotypic and genotypic heterogeneity. (11279625)
2001
15
Burkitt's acute lymphocytic leukemia (L3ALL) in adults. (11253608)
2001
16
Central nervous system involvement in adult acute lymphocytic leukemia. (11253605)
2001
17
Adult acute lymphocytic leukemia. Future research directions. (11253607)
2001
18
High-dose anthracycline induction in adult acute lymphocytic leukemia. (11253610)
2001
19
The hyper-CVAD regimen in adult acute lymphocytic leukemia. (11147229)
2000
20
Cytogenetics in adult acute lymphocytic leukemia. (11147221)
2000
21
Adult acute lymphocytic leukemia. Introduction and questions related to current programs. (11147219)
2000
22
Insights into the biologic and molecular abnormalities in adult acute lymphocytic leukemia. (11147223)
2000
23
Deletions and losses in chromosomes 5 or 7 in adult acute lymphocytic leukemia: incidence, associations and implications. (10360374)
1999
24
Familial neurofibromatosis type I and adult acute lymphocytic leukemia. (10329933)
1999
25
Analysis of the BCR-ABL protein in Philadelphia chromosome-positive adult acute lymphocytic leukemia. (9305617)
1997
26
The role of allogeneic bone marrow transplantation in the treatment of high-risk acute lymphocytic leukemia in adults. (9179276)
1997
27
Growth and biologic properties of karyotypically defined subcategories of adult acute lymphocytic leukemia in mice with severe combined immunodeficiency. (7492788)
1995
28
Myeloid markers in adult acute lymphocytic leukemia. Correlations with patient and disease characteristics and with prognosis. (8635059)
1995
29
Acute lymphocytic leukemia in adults: an update. (8140553)
1994
30
Acute lymphocytic leukemia in adults: a retrospective study and analysis of current management options. (7934190)
1994
31
Philadelphia-chromosome-positive adult acute lymphocytic leukemia: characteristics, treatment results, and prognosis in 41 patients. (8030658)
1994
32
Management of adult acute lymphocytic leukemia: present issues and key challenges. (8201394)
1994
33
Prognostic significance of elevated serum beta 2-microglobulin levels in adult acute lymphocytic leukemia. (1466355)
1992
34
Adult acute lymphocytic leukemia: the Eastern Cooperative Oncology Group experience. (1578927)
1992
35
Treatment of relapsed or refractory adult acute lymphocytic leukemia. (1730121)
1992
36
Phase III trial of brief intensive treatment of adult acute lymphocytic leukemia comparing daunorubicin and mitoxantrone: a CALGB Study. (2033963)
1991
37
The effects of postinduction intensification treatment with cytarabine and daunorubicin in adult acute lymphocytic leukemia: a prospective randomized clinical trial by Cancer and Leukemia Group B. (1941059)
1991
38
Improved results of an intensified therapy in adult acute lymphocytic leukemia. (2009234)
1991
39
Treatment of relapsed acute lymphocytic leukemia in adults. (2182434)
1990
40
The importance of cytogenetic studies in adult acute lymphocytic leukemia. (2239977)
1990
41
Testicular relapse in adult acute lymphocytic leukemia: a case report and literature review. (2649778)
1989
42
Identification of risk groups for development of central nervous system leukemia in adults with acute lymphocytic leukemia. (3052630)
1988
43
Efficacy of daunorubicin in the therapy of adult acute lymphocytic leukemia: a prospective randomized trial by cancer and leukemia group B. (6375760)
1984
44
Therapy of adult acute lymphocytic leukemia. (6594761)
1984
45
Moderate dose methotrexate, vincristine, asparaginase, and dexamethasone for treatment of adult acute lymphocytic leukemia. (7034815)
1982
46
High-dose methotrexate for the remission induction of refractory adult acute lymphocytic leukemia. (370537)
1978
47
Remission induction with daunomycin, vincristine, and prednisone in adult acute lymphocytic leukemia. (266674)
1977
48
Remission induction in adult acute lymphocytic leukemia. Use of vincristine and prednisone alone. (1067890)
1976
49
Combination chemotherapy of adult acute lymphocytic leukemia. (770047)
1976
50
Results of therapy in adult acute lymphocytic leukemia. (1064827)
1975

Genetic Variations for Adult Acute Lymphocytic Leukemia

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Expression for genes affiliated with Adult Acute Lymphocytic Leukemia

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Sources:
1BioGPS, 15Gene Expression Omnibus DataSets
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Expression patterns in normal tissues for genes affiliated with Adult Acute Lymphocytic Leukemia

Search GEO for disease gene expression data for Adult Acute Lymphocytic Leukemia.

Pathways for genes affiliated with Adult Acute Lymphocytic Leukemia

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Sources:
49PharmGKB, 53Reactome, 37NCBI BioSystems Database, 29KEGG
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Compounds for genes affiliated with Adult Acute Lymphocytic Leukemia

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Sources:
44Novoseek, 49PharmGKB, 11DrugBank, 24HMDB, 59Tocris Bioscience
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Compounds related to Adult Acute Lymphocytic Leukemia according to GeneCards/GeneDecks:

(show top 50)    (show all 67)
idCompoundScoreTop Affiliating Genes
1ch2h4folate4410.2MTHFR, TYMS
2methyl-group4410.2MTR, MTHFR
3pemetrexed49 1111.1TYMS, MTHFR
4adenosylcobalamin44 2411.1MTHFR, MTR
55,10-methenyltetrahydrofolate4410.1MTHFR, MTR
6methylcobalamin44 2411.1MTHFR, MTR
7edatrexate4410.0CSF3, TYMS
8cyanocobalamin49 11 2412.0MTR, MTHFR
9Tetrahydrofolic acid11 2411.0SHMT1, MTHFR, MTR
10ara-ctp4410.0TYMS, CSF3
1110-formyltetrahydrofolate4410.0MTR, MTHFR
12thiopurine449.9ABCG2, MTHFR, TYMS
13hydroxocobalamin44 1110.9MTHFR, MTR
14fluorouracil49 1110.9MTHFR, TYMS, ABCG2
15vitamin b12449.9TYMS, MTHFR, MTR
16oxaliplatin44 49 1111.9TYMS, MTHFR, ABCG2
175-aza-2deoxycytidine449.8CDKN1C, CDX1, CDKN2B, CDX2
185-methyltetrahydrofolate44 1110.8MTHFR, MTR
199-aminocamptothecin449.8ABCG2, TYMS, CSF3
20b vitamins449.8TYMS, MTHFR, SHMT1, MTR
21tetrahydrofolate449.8MTHFR, MTR, SHMT1, TYMS
22vitamin b6449.8MTHFR, MTR, TYMS, SHMT1
23pyridoxal 5-phosphate449.8MTHFR, SHMT1, TYMS, MTR
24vinorelbine44 1110.8ABCG2, CSF3, TYMS
25purine44 2410.7SHMT1, MTR, MTHFR, TYMS
26thymidylate449.7MTHFR, TYMS, SHMT1, MTR
27topotecan44 1110.7ABCG2, CSF3, TYMS
28leucovorin44 49 1111.7MTHFR, TYMS, CSF3
296 mercaptopurine449.6MTHFR, CSF3, ABCG2
30zidovudine44 1110.6CSF3, TYMS, ABCG2
31methionine449.5MTHFR, MTR, MME, SHMT1
32taxane449.4ABCG2, MTHFR, TYMS, CSF3
33adriamycin449.4MME, TYMS, CSF3, ABCG2
34folate449.4SHMT1, TYMS, ABCG2, MTHFR, MTR
35irinotecan44 49 1111.4CSF3, TYMS, MTHFR, ABCG2
36carboplatin44 49 1111.4CSF3, MTHFR, TYMS, ABCG2
37gemcitabine44 49 1111.4MTHFR, ABCG2, TYMS, CSF3
38valine449.4CSF3, MTHFR, MTR, TYMS
395fluorouracil449.3ABCG2, CSF3, TYMS, MTHFR
404-hydroperoxycyclophosphamide449.3CD34, CSF3
41hydroxyurea44 49 1111.3CSF3, ABCG2, TYMS
42cytarabine44 49 1111.3MME, TYMS, ABCG2, CSF3, CDKN2B
43dihydrofolate449.2MTHFR, MTR, SHMT1, TYMS, CDKN2B, ABCG2
44mitomycin c449.1ABCG2, TYMS, CSF3
45doxorubicin44 49 1111.0CSF3, TYMS, ABCG2, MME
46cisplatin44 49 59 1112.0TYMS, ABCG2, MTR, MTHFR, CSF3
47methotrexate44 49 1110.7ABCG2, CDKN2B, SHMT1, MTR, TYMS, MTHFR
48thymidine44 249.3MME, CSF3, MTHFR, TYMS, CDX2, CD34
49retinoic acid44 249.3CSF3, MTHFR, MME, CD34, CDKN2B, CDX1
50tyrosine447.4ABCG2, MME, CDX2, CDKN2B, TOM1, CSF3

GO Terms for genes affiliated with Adult Acute Lymphocytic Leukemia

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16Gene Ontology
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Biological processes related to Adult Acute Lymphocytic Leukemia according to GeneCards/GeneDecks:

(show all 9)
idNameGO IDScoreTop Affiliating Genes
1tetrahydrofolate interconversionGO:03599910.1MTHFR, SHMT1
2folic acid metabolic processGO:04665510.0SHMT1, MTHFR
3positive regulation of transforming growth factor beta receptor signaling pathwayGO:03051110.0CDKN1C, CDKN2B
4labyrinthine layer developmentGO:0607119.9CDX4, CDX2
5water-soluble vitamin metabolic processGO:0067679.7SHMT1, MTR, MTHFR
6negative regulation of phosphorylationGO:0423269.7CDKN2B, CDKN1C
7vitamin metabolic processGO:0067669.6SHMT1, MTHFR, MTR
8cellular response to cytokine stimulusGO:0713459.5MME, CSF3
9anterior/posterior pattern specificationGO:0099529.5CDX2, CDX4, CDX1

Molecular functions related to Adult Acute Lymphocytic Leukemia according to GeneCards/GeneDecks:

idNameGO IDScoreTop Affiliating Genes
1cyclin-dependent protein serine/threonine kinase inhibitor activityGO:00486110.0CDKN1C, CDKN2B
2transcription regulatory region sequence-specific DNA bindingGO:0009768.9DLX4, CDX4, CDX2

Products for genes affiliated with Adult Acute Lymphocytic Leukemia

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Sources for Adult Acute Lymphocytic Leukemia

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3CDC
13ExPASy
14FMA
22GTR
23HGMD
24HMDB
25ICD10
26ICD10 via Orphanet
27ICD9CM
28IUPHAR
29KEGG
34MeSH
35MESH via Orphanet
36MGI
39NCIt
40NDF-RT
43NINDS
44Novoseek
46OMIM
47OMIM via Orphanet
50PubMed
51QIAGEN
57SNOMED-CT via Orphanet
60UMLS
61UMLS via Orphanet