MCID: ADL053
MIFTS: 32

Adult Astrocytic Tumour

Categories: Cancer diseases

Aliases & Classifications for Adult Astrocytic Tumour

MalaCards integrated aliases for Adult Astrocytic Tumour:

Name: Adult Astrocytic Tumour 12 14
Adult Astrocytic Tumors 69
Adult Astrocytoma 12

Classifications:



External Ids:

Disease Ontology 12 DOID:3076
NCIt 46 C7049
UMLS 69 C1332183

Summaries for Adult Astrocytic Tumour

MalaCards based summary : Adult Astrocytic Tumour, also known as adult astrocytic tumors, is related to oligodendroglioma and astrocytoma. An important gene associated with Adult Astrocytic Tumour is ATRX (ATRX, Chromatin Remodeler), and among its related pathways/superpathways are Integrin Pathway and Degradation of the extracellular matrix. The drugs Entinostat and Histone Deacetylase Inhibitors have been mentioned in the context of this disorder. Affiliated tissues include liver, and related phenotypes are neoplasm and vision/eye

Related Diseases for Adult Astrocytic Tumour

Diseases related to Adult Astrocytic Tumour via text searches within MalaCards or GeneCards Suite gene sharing:

(show top 50) (show all 78)
# Related Disease Score Top Affiliating Genes
1 oligodendroglioma 29.4 IDH1 IDH2 PTEN
2 astrocytoma 29.2 IDH1 MMP9 PTEN
3 interval angle-closure glaucoma 10.5 IDH1 IDH2
4 adult oligodendroglioma 10.5 IDH1 IDH2
5 enchondroma 10.5 IDH1 IDH2
6 intracranial chondrosarcoma 10.5 IDH1 IDH2
7 anaplastic oligodendroglioma 10.5 IDH1 IDH2
8 cytogenetically normal acute myeloid leukemia 10.4 IDH1 IDH2
9 intraductal papilloma 10.4 IDH1 IDH2
10 multiple enchondromatosis, maffucci type 10.4 IDH1 IDH2
11 spindle cell hemangioma 10.4 IDH1 IDH2
12 periosteal chondrosarcoma 10.4 IDH1 IDH2
13 undifferentiated pleomorphic sarcoma 10.4 IDH1 IDH2
14 superior limbic keratoconjunctivitis 10.4 MMP1 MMP3
15 bone giant cell sarcoma 10.3 H3F3A H3F3B
16 nodular ganglioneuroblastoma 10.3 ATRX BDNF
17 drug-induced mental disorder 10.3 IDH1 IDH2
18 clear cell chondrosarcoma 10.3 H3F3A H3F3B
19 malignant giant cell tumor 10.3 H3F3A H3F3B
20 conjunctivochalasis 10.3 MMP1 MMP3
21 drug psychosis 10.2 IDH1 IDH2
22 glioma susceptibility 1 10.2 H3F3A IDH1 IDH2
23 chondroblastic osteosarcoma 10.2 H3F3A IDH1 IDH2
24 brain stem cancer 10.2 H3F3A H3F3B
25 gemistocytic astrocytoma 10.2 IDH2 PTEN
26 diffuse infiltrative lymphocytosis syndrome 10.2 IDH1 IDH2
27 corneal edema 10.2 MMP1 MMP3
28 diffuse intrinsic pontine glioma 10.2 H3F3A H3F3B
29 cannabis abuse 10.2 BDNF NGF
30 epidermolysis bullosa dystrophica 10.2 MMP1 MMP3
31 chondroblastoma 10.1 H3F3A H3F3B
32 coronary artery aneurysm 10.1 MMP1 MMP3 MMP7
33 septic arthritis 10.1 MMP3 MMP7
34 gliomatosis cerebri 10.1 IDH1 PTEN
35 focal myositis 10.1 MMP7 MMP9
36 2-hydroxyglutaric aciduria 10.1 IDH1 IDH2
37 senile ectropion 10.1 MMP7 MMP9
38 spinal cord astrocytoma 10.1 H3F3A H3F3B IDH1
39 fibrillary astrocytoma 10.1 ATRX H3F3A IDH1 IDH2
40 rheumatoid nodulosis 10.0 MMP3 MMP9
41 brain glioblastoma multiforme 10.0 MMP7 MMP9
42 paine syndrome 10.0 BDNF NGF
43 gingival hypertrophy 10.0 MMP3 MMP9
44 pediatric multiple sclerosis 10.0 MMP7 MMP9
45 blepharochalasis 10.0 MMP3 MMP9
46 brain cancer 10.0 IDH1 IDH2 PTEN
47 chronic actinic dermatitis 10.0 MMP1 MMP9
48 tendinosis 10.0 BDNF MMP1 MMP3
49 chromoblastomycosis 9.9 MMP1 MMP9
50 sorsby fundus dystrophy 9.9 MMP3 MMP9

Graphical network of the top 20 diseases related to Adult Astrocytic Tumour:



Diseases related to Adult Astrocytic Tumour

Symptoms & Phenotypes for Adult Astrocytic Tumour

MGI Mouse Phenotypes related to Adult Astrocytic Tumour:

43
# Description MGI Source Accession Score Top Affiliating Genes
1 neoplasm MP:0002006 9.35 IDH2 MMP1 MMP7 MMP9 PTEN
2 vision/eye MP:0005391 9.1 ATRX BDNF MMP7 MMP9 NGF PTEN

Drugs & Therapeutics for Adult Astrocytic Tumour

Drugs for Adult Astrocytic Tumour (from DrugBank, HMDB, Dgidb, PharmGKB, IUPHAR, NovoSeek, BitterDB):


# Name Status Phase Clinical Trials Cas Number PubChem Id
1
Entinostat Investigational Phase 1 209783-80-2
2 Histone Deacetylase Inhibitors Phase 1
3 Liver Extracts Phase 1
4 Cola Nutraceutical Phase 1

Interventional clinical trials:


# Name Status NCT ID Phase Drugs
1 MS-275 in Treating Patients With Advanced Solid Tumors or Lymphoma Completed NCT00020579 Phase 1 entinostat
2 Study of Genes and Environment in Patients With Cancer in East Anglia, Trent, or West Midlands Regions of the United Kingdom Unknown status NCT00757614
3 Decision Making About Participating in Pharmacokinetic Studies in Patients Enrolled in a Phase I Treatment Clinical Trial Completed NCT00890435

Search NIH Clinical Center for Adult Astrocytic Tumour

Genetic Tests for Adult Astrocytic Tumour

Anatomical Context for Adult Astrocytic Tumour

MalaCards organs/tissues related to Adult Astrocytic Tumour:

38
Liver

Publications for Adult Astrocytic Tumour

Articles related to Adult Astrocytic Tumour:

# Title Authors Year
1
p53-independent mechanisms regulate the P2-MDM2 promoter in adult astrocytic tumours. ( 18781178 )
2008
2
Galectin-3 and galectin-3-binding site expression in human adult astrocytic tumours and related angiogenesis. ( 10476049 )
1999

Variations for Adult Astrocytic Tumour

Expression for Adult Astrocytic Tumour

Search GEO for disease gene expression data for Adult Astrocytic Tumour.

Pathways for Adult Astrocytic Tumour

Pathways related to Adult Astrocytic Tumour according to GeneCards Suite gene sharing:

(show all 16)
# Super pathways Score Top Affiliating Genes
1
Show member pathways
13.05 MMP1 MMP3 MMP7 MMP9 PTEN
2
Show member pathways
12.45 MMP1 MMP3 MMP7 MMP9
3 11.94 H3F3A H3F3B MMP3 MMP9
4 11.93 MMP1 MMP7 MMP9
5
Show member pathways
11.93 MMP1 MMP3 MMP7 MMP9
6 11.71 MMP1 MMP3 MMP9
7 11.55 MMP3 MMP7 MMP9
8
Show member pathways
11.55 MMP1 MMP3 MMP7 MMP9
9
Show member pathways
11.38 MMP1 MMP3 MMP9
10 11.09 MMP1 MMP9
11 11.09 MMP1 MMP3 MMP9
12
Show member pathways
11.08 BDNF MMP3 MMP7 NGF
13 11.07 H3F3A H3F3B
14 10.71 MMP1 MMP3 MMP7 MMP9
15
Show member pathways
10.57 IDH1 IDH2
16 10.56 MMP1 MMP7 MMP9

GO Terms for Adult Astrocytic Tumour

Cellular components related to Adult Astrocytic Tumour according to GeneCards Suite gene sharing:

# Name GO ID Score Top Affiliating Genes
1 extracellular matrix GO:0031012 9.56 MMP1 MMP3 MMP7 MMP9
2 nuclear chromosome, telomeric region GO:0000784 9.5 ATRX H3F3A H3F3B
3 proteinaceous extracellular matrix GO:0005578 9.46 MMP1 MMP3 MMP7 MMP9
4 extracellular region GO:0005576 9.32 BDNF H3F3A H3F3B IDH1 MMP1 MMP3
5 nuclear chromosome GO:0000228 9.13 ATRX H3F3A H3F3B

Biological processes related to Adult Astrocytic Tumour according to GeneCards Suite gene sharing:

(show all 11)
# Name GO ID Score Top Affiliating Genes
1 nucleosome assembly GO:0006334 9.58 ATRX H3F3A H3F3B
2 tricarboxylic acid cycle GO:0006099 9.49 IDH1 IDH2
3 telomere organization GO:0032200 9.48 H3F3A H3F3B
4 2-oxoglutarate metabolic process GO:0006103 9.46 IDH1 IDH2
5 positive regulation of protein oligomerization GO:0032461 9.43 MMP1 MMP3
6 positive regulation of receptor binding GO:1900122 9.37 BDNF MMP9
7 DNA replication-independent nucleosome assembly GO:0006336 9.33 ATRX H3F3A H3F3B
8 isocitrate metabolic process GO:0006102 9.32 IDH1 IDH2
9 glyoxylate cycle GO:0006097 9.26 IDH1 IDH2
10 extracellular matrix disassembly GO:0022617 9.26 MMP1 MMP3 MMP7 MMP9
11 collagen catabolic process GO:0030574 8.92 MMP1 MMP3 MMP7 MMP9

Molecular functions related to Adult Astrocytic Tumour according to GeneCards Suite gene sharing:

(show all 11)
# Name GO ID Score Top Affiliating Genes
1 hydrolase activity GO:0016787 9.91 ATRX MMP1 MMP3 MMP7 MMP9 PTEN
2 peptidase activity GO:0008233 9.78 MMP1 MMP3 MMP7 MMP9
3 magnesium ion binding GO:0000287 9.67 IDH1 IDH2 PTEN
4 serine-type endopeptidase activity GO:0004252 9.62 MMP1 MMP3 MMP7 MMP9
5 histone binding GO:0042393 9.58 ATRX H3F3A H3F3B
6 metallopeptidase activity GO:0008237 9.56 MMP1 MMP3 MMP7 MMP9
7 endopeptidase activity GO:0004175 9.54 MMP1 MMP3 MMP9
8 oxidoreductase activity, acting on the CH-OH group of donors, NAD or NADP as acceptor GO:0016616 9.46 IDH1 IDH2
9 isocitrate dehydrogenase activity GO:0004448 9.16 IDH1 IDH2
10 isocitrate dehydrogenase (NADP+) activity GO:0004450 8.96 IDH1 IDH2
11 metalloendopeptidase activity GO:0004222 8.92 MMP1 MMP3 MMP7 MMP9

Sources for Adult Astrocytic Tumour

3 CDC
7 CNVD
9 Cosmic
10 dbSNP
11 DGIdb
16 ExPASy
18 FMA
27 GO
28 GTR
29 HGMD
30 HMDB
31 HPO
32 ICD10
33 ICD10 via Orphanet
34 ICD9CM
35 IUPHAR
36 KEGG
37 LifeMap
39 MedGen
41 MeSH
42 MESH via Orphanet
43 MGI
45 NCI
46 NCIt
47 NDF-RT
50 NINDS
51 Novoseek
53 OMIM
54 OMIM via Orphanet
58 PubMed
60 QIAGEN
65 SNOMED-CT via HPO
66 SNOMED-CT via Orphanet
67 TGDB
68 Tocris
69 UMLS
70 UMLS via Orphanet
Content
Loading form....