MCID: ADL053
MIFTS: 24

Adult Astrocytic Tumour malady

Cancer category

Summaries for Adult Astrocytic Tumour

Sources:
33MalaCards
See all sources

Fully expand this MalaCard

Export this MalaCard
MalaCards: Adult Astrocytic Tumour, also known as adult astrocytic tumors, is related to astrocytoma and adult oligodendroglioma. An important gene associated with Adult Astrocytic Tumour is LGALS3 (lectin, galactoside-binding, soluble, 3), and among its related pathways are Aurora A signaling and DNA damage ATM/ATR regulation of G1/S checkpoint. The compounds paraffin and 7,12-dimethylbenz(a)anthracene have been mentioned in the context of this disorder.

Aliases & Classifications for Adult Astrocytic Tumour

Sources:
8Disease Ontology, 61UMLS, 40NCIt
See all sources

Classifications:

Malacards categories (disease lists): (See all malacards categories)
Global: Cancer


Aliases & Descriptions:

adult astrocytic tumour 8
adult astrocytic tumors 61
adult astrocytoma 8


External Ids:

Disease Ontology8 DOID:3076
NCIt40 C7049

Related Diseases for Adult Astrocytic Tumour

Sources:
17GeneCards, 18GeneDecks
See all sources

Diseases related to Adult Astrocytic Tumour via text searches within MalaCards or GeneCards/GeneDecks gene sharing:

(show top 50)    (show all 54)
idRelated DiseaseScoreTop Affiliating Genes
1astrocytoma30.3TP53, LGALS3, CDKN2A, MDM2
2adult oligodendroglioma10.1
3chordoma10.0LGALS3
4smooth muscle tumor10.0LGALS3
5pilocytic astrocytoma10.0LGALS3
6cholesteatoma10.0LGALS3
7ependymoma10.0MDM2
8pituitary tumors10.0LGALS3
9fibrosarcoma10.0MDM2
10giant cell glioblastoma10.0MDM2
11lynch syndrome10.0TP53
12ductal carcinoma in situ10.0TP53
13uterine sarcoma10.0MDM2
14benign mesothelioma10.0TP53
15neuroblastoma10.0TP53
16benign meningioma10.0MDM2
17chondrosarcoma10.0MDM2
18malignant mesothelioma10.0CDKN2A
19cholangiocarcinoma10.0LGALS3, TP53
20thyroid cancer10.0LGALS3, TP53
21actinic keratosis10.0TP53
22leiomyosarcoma10.0TP53, MDM2
23dermatofibrosarcoma10.0MDM2
24liposarcoma10.0MDM2, TP53
25breast cancer, invasive ductal10.0MDM2, TP53
26li-fraumeni syndrome10.0TP53, CDKN2A
27skin cancer10.0TP53, CDKN2A
28oropharyngeal cancer, adult10.0TP53, CDKN2A
29thyroid cancer, anaplastic10.0TP53, LGALS3
30malignant peripheral nerve sheath tumor10.0CDKN2A, MDM2
31laryngeal squamous cell carcinoma10.0TP53, CDKN2A
32nasopharynx carcinoma10.0CDKN2A, TP53
33endometrial carcinoma10.0CDKN2A, TP53
34anaplastic oligodendroglioma10.0LGALS3, MDM2, CDKN2A
35prostate cancer10.0LGALS3, MDM2, TP53
36barrett's esophagus10.0CDKN2A, TP53
37squamous cell carcinoma of the head and neck10.0TP53, LGALS3, CDKN2A
38bladder carcinoma in situ10.0TP53, CDKN2A
39esophageal cancer10.0TP53, CDKN2A, MDM2
40glioblastoma multiforme10.0TP53, CDKN2A, MDM2
41lung benign neoplasm10.0MDM2, CDKN2A, TP53
42cervical cancer10.0MDM2, TP53, CDKN2A
43b-cell lymphomas10.0CDKN2A, TP53, MDM2
44pancreatic cancer10.0CDKN2A, TP53, LGALS3
45intraocular melanoma10.0MDM2, CDKN2A
46bladder carcinoma10.0TP53, MDM2, CDKN2A
47oligodendroglioma10.0CDKN2A, MDM2, LGALS3, TP53
48anaplastic astrocytoma10.0MDM2, CDKN2A, LGALS3, TP53
49non-small cell lung carcinoma10.0LGALS3, TP53, MDM2, CDKN2A
50colorectal cancer10.0TP53, LGALS3, CDKN2A, MDM2

Graphical network of the top 20 diseases related to Adult Astrocytic Tumour:



Diseases related to adult astrocytic tumour

Clinical Features for Adult Astrocytic Tumour

Drugs & Therapeutics for Adult Astrocytic Tumour

Sources:
5CenterWatch, 42NIH Clinical Center, 6ClinicalTrials
See all sources

Approved drugs:

Search CenterWatch for Adult Astrocytic Tumour

Drug clinical trials:

Search ClinicalTrials for Adult Astrocytic Tumour

Search NIH Clinical Center for Adult Astrocytic Tumour

Search CenterWatch for Adult Astrocytic Tumour

Genetic Tests for Adult Astrocytic Tumour

Anatomical Context for Adult Astrocytic Tumour

Animal Models for Adult Astrocytic Tumour or affiliated genes

Sources:
28inGenious Targeting Laboratory
See all sources

Publications for Adult Astrocytic Tumour

Sources:
51PubMed
See all sources

Articles related to Adult Astrocytic Tumour:

idTitleAuthorsYear
1
p53-independent mechanisms regulate the P2-MDM2 promoter in adult astrocytic tumours. (18781178)
2008
2
Galectin-3 and galectin-3-binding site expression in human adult astrocytic tumours and related angiogenesis. (10476049)
1999

Genetic Variations for Adult Astrocytic Tumour

Expression for genes affiliated with Adult Astrocytic Tumour

Sources:
1BioGPS, 15Gene Expression Omnibus DataSets
See all sources
Expression patterns in normal tissues for genes affiliated with Adult Astrocytic Tumour

Search GEO for disease gene expression data for Adult Astrocytic Tumour.

Pathways for genes affiliated with Adult Astrocytic Tumour

Sources:
38NCBI BioSystems Database, 12EMD Millipore, 52QIAGEN, 30KEGG
See all sources

Compounds for genes affiliated with Adult Astrocytic Tumour

Sources:
45Novoseek, 50PharmGKB, 60Tocris Bioscience, 11DrugBank, 24HMDB, 29IUPHAR
See all sources

Compounds related to Adult Astrocytic Tumour according to GeneCards/GeneDecks:

(show all 41)
idCompoundScoreTop Affiliating Genes
1paraffin4510.2LGALS3, MDM2
27,12-dimethylbenz(a)anthracene4510.1CDKN2A, MDM2
310-hydroxycamptothecin4510.0TP53, MDM2
4acnu4510.0CDKN2A, TP53
5etoposide45 50 60 1112.9LGALS3, MDM2
6bpde459.9TP53, MDM2
7hpvs459.9TP53, CDKN2A
8chlorambucil45 1110.9MDM2, TP53
95-methylcytosine45 2410.9TP53, CDKN2A
10olomoucine45 1110.9TP53, CDKN2A
11temozolomide45 1110.8CDKN2A, TP53
12hmba459.8TP53, CDKN2A
13bcnu459.8CDKN2A, TP53
14noxa459.8TP53, MDM2
15o6-methylguanine459.8CDKN2A, TP53
16p00001459.8CDKN2A, MDM2
17dutp459.7TP53, LGALS3, MDM2
18leptomycin b45 6010.7TP53, LGALS3, MDM2
19agar459.6LGALS3, CDKN2A, MDM2
20aflatoxin b145 2410.6TP53, CDKN2A, MDM2
21roscovitine459.6MDM2, CDKN2A, TP53
22flavopiridol45 1110.6MDM2, CDKN2A, TP53
23irinotecan45 50 1111.6TP53, CDKN2A, MDM2
242-chlorodeoxyadenosine459.6MDM2, TP53
25thymidylate459.6TP53, CDKN2A, MDM2
26adriamycin459.6TP53, CDKN2A, MDM2
27docetaxel45 50 60 1112.6MDM2, CDKN2A, TP53
28camptothecin45 60 1111.6TP53, CDKN2A, MDM2
29mg 13245 6010.5MDM2, CDKN2A, TP53
305-aza-2deoxycytidine459.5MDM2, CDKN2A, TP53
31arsenite45 2410.5MDM2, CDKN2A, TP53
32crcs459.4CDKN2A, TP53
335fluorouracil459.4MDM2, CDKN2A, TP53
34cisplatin45 50 60 1112.2MDM2, CDKN2A, LGALS3, TP53
35progesterone45 60 29 11 2413.2TP53, LGALS3, CDKN2A, MDM2
36h2o2459.2TP53, LGALS3, CDKN2A, MDM2
37paclitaxel45 50 1111.2TP53, CDKN2A, MDM2
38oligonucleotide459.1TP53, LGALS3, CDKN2A, MDM2
39vegf459.0MDM2, CDKN2A, LGALS3, TP53
40arginine459.0MDM2, CDKN2A, LGALS3, TP53
41butyrate458.9TP53, LGALS3, CDKN2A

GO Terms for genes affiliated with Adult Astrocytic Tumour

Sources:
16Gene Ontology
See all sources

Cellular components related to Adult Astrocytic Tumour according to GeneCards/GeneDecks:

idNameGO IDScoreTop Affiliating Genes
1protein complexGO:0432349.2TP53, CDKN2A, MDM2
2nuclear bodyGO:0166048.9TP53, CDKN2A, MDM2

Biological processes related to Adult Astrocytic Tumour according to GeneCards/GeneDecks:

idNameGO IDScoreTop Affiliating Genes
1response to antibioticGO:0466779.6TP53, MDM2
2replicative senescenceGO:0903999.5TP53, CDKN2A
3positive regulation of cell cycle arrestGO:0711589.4TP53, CDKN2A
4protein destabilizationGO:0316489.4CDKN2A, MDM2

Molecular functions related to Adult Astrocytic Tumour according to GeneCards/GeneDecks:

idNameGO IDScoreTop Affiliating Genes
1MDM2/MDM4 family protein bindingGO:0973719.5TP53, CDKN2A
2p53 bindingGO:0020398.9TP53, CDKN2A, MDM2

Products for genes affiliated with Adult Astrocytic Tumour

  • Antibodies
  • Proteins
  • Lysates
  • Antibodies

Sources for Adult Astrocytic Tumour

3CDC
13ExPASy
14FMA
22GTR
23HGMD
24HMDB
25ICD10
26ICD10 via Orphanet
27ICD9CM
29IUPHAR
30KEGG
35MeSH
36MESH via Orphanet
37MGI
40NCIt
41NDF-RT
44NINDS
45Novoseek
47OMIM
48OMIM via Orphanet
51PubMed
52QIAGEN
58SNOMED-CT via Orphanet
61UMLS
62UMLS via Orphanet