MCID: ADL053
MIFTS: 30

Adult Astrocytic Tumour malady

Cancer diseases category

Summaries for Adult Astrocytic Tumour

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32MalaCards
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MalaCards: Adult Astrocytic Tumour, also known as adult astrocytic tumors, is related to astrocytoma and glioblastoma multiforme. An important gene associated with Adult Astrocytic Tumour is LGALS3 (lectin, galactoside-binding, soluble, 3), and among its related pathways are Aurora A signaling and DNA damage ATM/ATR regulation of G1/S checkpoint. The compounds paraffin and 7,12-dimethylbenz(a)anthracene have been mentioned in the context of this disorder.

Aliases & Classifications for Adult Astrocytic Tumour

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8Disease Ontology, 60UMLS, 39NCIt
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Classifications:

Malacards categories (disease lists): (See all malacards categories)
Global: Cancer diseases


Aliases & Descriptions:

adult astrocytic tumour 8
adult astrocytic tumors 60
adult astrocytoma 8


External Ids:

Disease Ontology8 DOID:3076
NCIt39 C7049

Related Diseases for Adult Astrocytic Tumour

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17GeneCards, 18GeneDecks
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Diseases related to Adult Astrocytic Tumour via text searches within MalaCards or GeneCards/GeneDecks gene sharing:

(show top 50)    (show all 53)
idRelated DiseaseScoreTop Affiliating Genes
1astrocytoma30.3TP53, LGALS3, CDKN2A, MDM2
2glioblastoma multiforme30.1MDM2, CDKN2A, TP53
3oligodendroglioma30.1MDM2, CDKN2A, LGALS3, TP53
4adult oligodendroglioma10.1
5chordoma10.0LGALS3
6smooth muscle tumor10.0LGALS3
7pilocytic astrocytoma10.0LGALS3
8cholesteatoma10.0LGALS3
9ependymoma10.0MDM2
10pituitary tumors10.0LGALS3
11fibrosarcoma10.0MDM2
12giant cell glioblastoma10.0MDM2
13lynch syndrome10.0TP53
14ductal carcinoma in situ10.0TP53
15uterine sarcoma10.0MDM2
16benign mesothelioma10.0TP53
17neuroblastoma10.0TP53
18benign meningioma10.0MDM2
19chondrosarcoma10.0MDM2
20malignant mesothelioma10.0CDKN2A
21dermatofibrosarcoma10.0MDM2
22cholangiocarcinoma10.0TP53, LGALS3
23thyroid cancer10.0LGALS3, TP53
24actinic keratosis10.0TP53
25leiomyosarcoma10.0TP53, MDM2
26liposarcoma10.0TP53, MDM2
27breast cancer, invasive ductal10.0MDM2, TP53
28li-fraumeni syndrome10.0CDKN2A, TP53
29oropharyngeal cancer, adult10.0TP53, CDKN2A
30thyroid cancer, anaplastic10.0LGALS3, TP53
31malignant peripheral nerve sheath tumor10.0MDM2, CDKN2A
32laryngeal squamous cell carcinoma10.0TP53, CDKN2A
33nasopharynx carcinoma10.0TP53, CDKN2A
34endometrial carcinoma10.0CDKN2A, TP53
35anaplastic oligodendroglioma10.0LGALS3, CDKN2A, MDM2
36prostate cancer10.0MDM2, LGALS3, TP53
37barrett's esophagus10.0CDKN2A, TP53
38squamous cell carcinoma of the head and neck10.0TP53, LGALS3, CDKN2A
39esophageal cancer10.0MDM2, CDKN2A, TP53
40lung benign neoplasm10.0TP53, CDKN2A, MDM2
41cervical cancer10.0MDM2, CDKN2A, TP53
42b-cell lymphomas10.0TP53, CDKN2A, MDM2
43pancreatic cancer10.0CDKN2A, LGALS3, TP53
44bladder carcinoma in situ10.0TP53, CDKN2A
45intraocular melanoma10.0CDKN2A, MDM2
46bladder carcinoma10.0TP53, CDKN2A, MDM2
47anaplastic astrocytoma10.0TP53, LGALS3, CDKN2A, MDM2
48non-small cell lung carcinoma10.0MDM2, CDKN2A, LGALS3, TP53
49colorectal cancer10.0MDM2, CDKN2A, LGALS3, TP53
50melanoma10.0TP53, LGALS3, CDKN2A, MDM2

Graphical network of the top 20 diseases related to Adult Astrocytic Tumour:



Diseases related to adult astrocytic tumour

Clinical Features for Adult Astrocytic Tumour

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Drugs & Therapeutics for Adult Astrocytic Tumour

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5CenterWatch, 41NIH Clinical Center, 6ClinicalTrials
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Approved drugs:

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Drug clinical trials:

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Search NIH Clinical Center for Adult Astrocytic Tumour

Search CenterWatch for Adult Astrocytic Tumour

Genetic Tests for Adult Astrocytic Tumour

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Anatomical Context for Adult Astrocytic Tumour

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Animal Models for Adult Astrocytic Tumour or affiliated genes

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Publications for Adult Astrocytic Tumour

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50PubMed
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Articles related to Adult Astrocytic Tumour:

idTitleAuthorsYear
1
p53-independent mechanisms regulate the P2-MDM2 promoter in adult astrocytic tumours. (18781178)
2008
2
Galectin-3 and galectin-3-binding site expression in human adult astrocytic tumours and related angiogenesis. (10476049)
1999

Genetic Variations for Adult Astrocytic Tumour

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Expression for genes affiliated with Adult Astrocytic Tumour

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1BioGPS, 15Gene Expression Omnibus DataSets
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Expression patterns in normal tissues for genes affiliated with Adult Astrocytic Tumour

Search GEO for disease gene expression data for Adult Astrocytic Tumour.

Pathways for genes affiliated with Adult Astrocytic Tumour

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Sources:
37NCBI BioSystems Database, 12EMD Millipore, 51QIAGEN, 29KEGG
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Compounds for genes affiliated with Adult Astrocytic Tumour

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Sources:
44Novoseek, 49PharmGKB, 59Tocris Bioscience, 11DrugBank, 24HMDB, 28IUPHAR
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Compounds related to Adult Astrocytic Tumour according to GeneCards/GeneDecks:

(show all 41)
idCompoundScoreTop Affiliating Genes
1paraffin4410.2LGALS3, MDM2
27,12-dimethylbenz(a)anthracene4410.1CDKN2A, MDM2
310-hydroxycamptothecin4410.0TP53, MDM2
4acnu4410.0CDKN2A, TP53
5etoposide44 49 59 1112.9LGALS3, MDM2
6bpde449.9MDM2, TP53
7hpvs449.9TP53, CDKN2A
8chlorambucil44 1110.9MDM2, TP53
9olomoucine44 1110.9CDKN2A, TP53
105-methylcytosine44 2410.9TP53, CDKN2A
11temozolomide44 1110.8TP53, CDKN2A
12hmba449.8CDKN2A, TP53
13o6-methylguanine449.8TP53, CDKN2A
14noxa449.8MDM2, TP53
15bcnu449.8CDKN2A, TP53
16p00001449.8CDKN2A, MDM2
17dutp449.7TP53, LGALS3, MDM2
18leptomycin b44 5910.7MDM2, LGALS3, TP53
19agar449.6LGALS3, CDKN2A, MDM2
20aflatoxin b144 2410.6TP53, MDM2, CDKN2A
21roscovitine449.6TP53, MDM2, CDKN2A
22flavopiridol44 1110.6TP53, MDM2, CDKN2A
23irinotecan44 49 1111.6TP53, CDKN2A, MDM2
24thymidylate449.6CDKN2A, TP53, MDM2
25adriamycin449.6TP53, CDKN2A, MDM2
26docetaxel44 49 59 1112.6TP53, CDKN2A, MDM2
27camptothecin44 59 1111.6MDM2, CDKN2A, TP53
28mg 13244 5910.5TP53, MDM2, CDKN2A
29crcs449.5CDKN2A, TP53
305-aza-2deoxycytidine449.5TP53, CDKN2A, MDM2
31arsenite44 2410.5TP53, CDKN2A, MDM2
322-chlorodeoxyadenosine449.5MDM2, TP53
335fluorouracil449.4MDM2, CDKN2A, TP53
34cisplatin44 49 59 1112.2TP53, CDKN2A, MDM2, LGALS3
35progesterone44 59 28 11 2413.2LGALS3, MDM2, CDKN2A, TP53
36h2o2449.2MDM2, CDKN2A, LGALS3, TP53
37paclitaxel44 49 1111.2CDKN2A, MDM2, TP53
38oligonucleotide449.1MDM2, CDKN2A, LGALS3, TP53
39vegf449.0TP53, LGALS3, CDKN2A, MDM2
40arginine449.0LGALS3, CDKN2A, MDM2, TP53
41butyrate448.9CDKN2A, TP53, LGALS3

GO Terms for genes affiliated with Adult Astrocytic Tumour

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16Gene Ontology
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Cellular components related to Adult Astrocytic Tumour according to GeneCards/GeneDecks:

idNameGO IDScoreTop Affiliating Genes
1protein complexGO:0432349.2TP53, CDKN2A, MDM2
2nuclear bodyGO:0166048.9TP53, CDKN2A, MDM2

Biological processes related to Adult Astrocytic Tumour according to GeneCards/GeneDecks:

idNameGO IDScoreTop Affiliating Genes
1response to antibioticGO:0466779.6TP53, MDM2
2replicative senescenceGO:0903999.5TP53, CDKN2A
3positive regulation of cell cycle arrestGO:0711589.4TP53, CDKN2A
4protein destabilizationGO:0316489.4CDKN2A, MDM2

Molecular functions related to Adult Astrocytic Tumour according to GeneCards/GeneDecks:

idNameGO IDScoreTop Affiliating Genes
1MDM2/MDM4 family protein bindingGO:0973719.5TP53, CDKN2A
2p53 bindingGO:0020398.9TP53, CDKN2A, MDM2

Products for genes affiliated with Adult Astrocytic Tumour

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Sources for Adult Astrocytic Tumour

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3CDC
13ExPASy
14FMA
22GTR
23HGMD
24HMDB
25ICD10
26ICD10 via Orphanet
27ICD9CM
28IUPHAR
29KEGG
34MeSH
35MESH via Orphanet
36MGI
39NCIt
40NDF-RT
43NINDS
44Novoseek
46OMIM
47OMIM via Orphanet
50PubMed
51QIAGEN
57SNOMED-CT via Orphanet
60UMLS
61UMLS via Orphanet