MCID: ADL053
MIFTS: 38

Adult Astrocytic Tumour malady

Cancer diseases category
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Summaries for Adult Astrocytic Tumour

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MalaCards based summary: Adult Astrocytic Tumour, also known as adult astrocytoma, is related to astrocytoma and actinic keratosis. An important gene associated with Adult Astrocytic Tumour is LGALS3 (lectin, galactoside-binding, soluble, 3), and among its related pathways are Spinal Cord Injury and ErbB signaling pathway. The compounds 10-hydroxycamptothecin and bpde have been mentioned in the context of this disorder. Related mouse phenotypes are renal/urinary system and pigmentation.

Aliases & Classifications for Adult Astrocytic Tumour

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Adult Astrocytic Tumour, Aliases & Descriptions:

Name: Adult Astrocytic Tumour 8
Adult Astrocytoma 8 62
 
Adult Astrocytic Tumors 62


Classifications:

Malacards categories (disease lists): (See all malacards categories)
Global: Cancer diseases


External Ids:

Disease Ontology8 DOID:3076
NCIt39 C7049

Related Diseases for Adult Astrocytic Tumour

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Diseases related to Adult Astrocytic Tumour via text searches within MalaCards or GeneCards/GeneDecks gene sharing:

(show top 50)    (show all 57)
idRelated DiseaseScoreTop Affiliating Genes
1astrocytoma29.8TP53, LGALS3, MDM2, CDKN2A
2actinic keratosis10.4TP53
3giant cell glioblastoma10.4MDM2
4thyroid cancer, anaplastic10.2TP53, LGALS3
5breast cancer, invasive ductal10.2MDM2, TP53
6liposarcoma10.1TP53, MDM2
7cholangiocarcinoma10.1LGALS3, TP53
8basal cell carcinoma10.1TP53, LGALS3
9leiomyosarcoma10.1TP53, MDM2
10thyroid hurthle cell carcinoma10.1TP53, LGALS3
11li-fraumeni syndrome10.1TP53, CDKN2A
12oropharyngeal cancer, adult10.1CDKN2A, TP53
13ataxia telangiectasia10.1MDM2, TP53
14nasopharynx carcinoma10.1CDKN2A, TP53
15transitional cell carcinoma10.1TP53, MDM2
16barrett's esophagus10.0CDKN2A, TP53
17bladder carcinoma in situ10.0CDKN2A, TP53
18rhabdomyosarcoma10.0TP53, MDM2
19laryngeal squamous cell carcinoma10.0TP53, CDKN2A
20esophageal cancer10.0TP53, CDKN2A
21papilloma10.0CDKN2A, TP53
22malignant peripheral nerve sheath tumor10.0MDM2, CDKN2A
23uveal melanoma10.0CDKN2A, MDM2
24squamous cell carcinoma of the head and neck10.0CDKN2A, TP53
25multiple myeloma10.0TP53, CDKN2A
26acute lymphoblastic leukemia, childhood10.0MDM2, CDKN2A
27breast cancer9.9LGALS3, TP53, MDM2
28lung small cell carcinoma9.9TP53, CDKN2A
29lung adenocarcinoma9.8TP53, CDKN2A
30pancreatic cancer9.8CDKN2A, LGALS3, TP53
31anaplastic oligodendroglioma9.8LGALS3, MDM2, CDKN2A
32oral cancer9.8CDKN2A, MDM2, TP53
33adenoma9.8LGALS3, TP53, CDKN2A
34glioblastoma multiforme9.8TP53, CDKN2A, MDM2
35lung benign neoplasm9.8MDM2, TP53, CDKN2A
36b-cell lymphomas9.8CDKN2A, MDM2, TP53
37malignant glioma9.8TP53, MDM2, CDKN2A
38cervical cancer9.8TP53, MDM2, CDKN2A
39bladder carcinoma9.8CDKN2A, MDM2, TP53
40osteosarcoma9.8TP53, MDM2, CDKN2A
41prostate cancer9.8LGALS3, TP53, MDM2
42retinoblastoma9.8MDM2, CDKN2A, TP53
43non-small cell lung carcinoma9.8MDM2, TP53, CDKN2A
44ovarian cancer9.8MDM2, CDKN2A, TP53
45endometrial carcinoma9.8CDKN2A, TP53
46liver cancer9.7CDKN2A, MDM2, TP53
47lung cancer9.7CDKN2A, TP53, MDM2
48leukemia9.6TP53, CDKN2A, MDM2
49grade iii astrocytoma9.6LGALS3, CDKN2A, MDM2, TP53
50oligodendroglioma9.6MDM2, CDKN2A, LGALS3, TP53

Graphical network of the top 20 diseases related to Adult Astrocytic Tumour:



Diseases related to adult astrocytic tumour

Symptoms for Adult Astrocytic Tumour

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Drugs & Therapeutics for Adult Astrocytic Tumour

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Drug clinical trials:

Search ClinicalTrials for Adult Astrocytic Tumour

Search NIH Clinical Center for Adult Astrocytic Tumour

Genetic Tests for Adult Astrocytic Tumour

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Anatomical Context for Adult Astrocytic Tumour

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Animal Models for Adult Astrocytic Tumour or affiliated genes

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Publications for Adult Astrocytic Tumour

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Articles related to Adult Astrocytic Tumour:

idTitleAuthorsYear
1
p53-independent mechanisms regulate the P2-MDM2 promoter in adult astrocytic tumours. (18781178)
2008
2
Galectin-3 and galectin-3-binding site expression in human adult astrocytic tumours and related angiogenesis. (10476049)
1999

Variations for Adult Astrocytic Tumour

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Expression for genes affiliated with Adult Astrocytic Tumour

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Expression patterns in normal tissues for genes affiliated with Adult Astrocytic Tumour

Search GEO for disease gene expression data for Adult Astrocytic Tumour.

Pathways for genes affiliated with Adult Astrocytic Tumour

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Pathways related to Adult Astrocytic Tumour according to GeneCards/GeneDecks:

(show all 47)
idSuper pathways (with members indented)ScoreTop Affiliating Genes
19.4TP53, LGALS3
2
Show member pathways
ErbB receptor signaling network37
ErbB signaling pathway37
9.3TP53, MDM2
39.3TP53, MDM2
4
Show member pathways
Prostate Cancer37
Integrated Cancer pathway37
Steroid Biosynthesis37
9.3TP53, MDM2
59.3TP53, MDM2
6
Show member pathways
p53 pathway37
9.3TP53, MDM2
79.3TP53, MDM2
8
Show member pathways
ATM Signaling Pathway37
9.3TP53, MDM2
9
Show member pathways
Signal transduction PTEN pathway60
9.3TP53, MDM2
10
Show member pathways
9.3TP53, MDM2
119.3TP53, MDM2
129.3TP53, MDM2
139.3TP53, MDM2
14
Show member pathways
9.3TP53, MDM2
159.3MDM2, TP53
16
Show member pathways
DNA damage Role of SUMO in p53 regulation60
9.3MDM2, TP53
179.3MDM2, TP53
189.3MDM2, TP53
199.3MDM2, TP53
20
Show member pathways
Immune response IL 4 signaling pathway60
Signal transduction AKT signaling60
9.3MDM2, TP53
219.3MDM2, TP53
229.3MDM2, TP53
23
Show member pathways
9.3MDM2, TP53
24
Show member pathways
9.1TP53, CDKN2A
258.5TP53, MDM2, CDKN2A
26
Show member pathways
8.5TP53, MDM2, CDKN2A
27
Show member pathways
8.5TP53, MDM2, CDKN2A
28
Show member pathways
8.5MDM2, CDKN2A, TP53
29
Show member pathways
8.5CDKN2A, TP53, MDM2
30
Show member pathways
Apoptosis Modulation and Signaling37
Apoptosis37
8.5MDM2, CDKN2A, TP53
31
Show member pathways
Cell cycle37
8.5CDKN2A, MDM2, TP53
32
Show member pathways
8.5CDKN2A, TP53, MDM2
33
Show member pathways
DNA damage response37
8.5CDKN2A, TP53, MDM2
348.5CDKN2A, TP53, MDM2
358.5MDM2, CDKN2A, TP53
36
Show member pathways
8.5CDKN2A, MDM2, TP53
37
Show member pathways
DNA damage response (only ATM dependent)37
Wnt Signaling Pathway and Pluripotency37
8.5TP53, CDKN2A, MDM2
388.5TP53, CDKN2A, MDM2
39
Show member pathways
8.5CDKN2A, TP53, MDM2
40
Show member pathways
Signaling Pathways in Glioblastoma37
8.5CDKN2A, TP53, MDM2
41
Show member pathways
8.5CDKN2A, TP53, MDM2
428.5TP53, CDKN2A, MDM2
43
Show member pathways
8.5CDKN2A, TP53, MDM2
448.5MDM2, TP53, CDKN2A
458.5MDM2, TP53, CDKN2A
468.5MDM2, TP53, CDKN2A
478.5MDM2, TP53, CDKN2A

Compounds for genes affiliated with Adult Astrocytic Tumour

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Compounds related to Adult Astrocytic Tumour according to GeneCards/GeneDecks:

(show top 50)    (show all 78)
idCompoundScoreTop Affiliating Genes
110-hydroxycamptothecin449.7MDM2, TP53
2bpde449.7TP53, MDM2
3chlorambucil44 1110.7TP53, MDM2
4acnu449.5TP53, CDKN2A
5hpvs449.5TP53, CDKN2A
6noxa449.5MDM2, TP53
75-methylcytosine44 2410.4CDKN2A, TP53
8olomoucine44 1110.4TP53, CDKN2A
92-chlorodeoxyadenosine449.4MDM2, TP53
10temozolomide44 1110.4CDKN2A, TP53
117,12-dimethylbenz(a)anthracene449.4MDM2, CDKN2A
12hmba449.4TP53, CDKN2A
13bcnu449.4TP53, CDKN2A
14o6-methylguanine449.3CDKN2A, TP53
15dutp449.3MDM2, TP53, LGALS3
16leptomycin b44 6110.3LGALS3, TP53, MDM2
17etoposide44 50 61 1112.2TP53, LGALS3, MDM2
18p00001449.1CDKN2A, MDM2
19crcs449.1CDKN2A, TP53
20depsipeptide449.1CDKN2A, TP53
21methylmethanesulfonate449.0TP53, MDM2
22proline449.0LGALS3, MDM2, TP53
23aflatoxin b144 2410.0TP53, CDKN2A, MDM2
24butyrate449.0CDKN2A, LGALS3, TP53
25roscovitine449.0CDKN2A, TP53, MDM2
26flavopiridol44 119.9CDKN2A, MDM2, TP53
27irinotecan44 50 1110.9TP53, MDM2, CDKN2A
28thymidylate448.9TP53, MDM2, CDKN2A
29vincristine44 50 1110.9MDM2, TP53, CDKN2A
30adriamycin448.9CDKN2A, TP53, MDM2
31camptothecin44 61 1110.9CDKN2A, TP53, MDM2
32docetaxel44 50 61 1111.9CDKN2A, MDM2, TP53
33mg 13244 619.9TP53, CDKN2A, MDM2
345-aza-2deoxycytidine448.9TP53, MDM2, CDKN2A
35arsenite44 249.9MDM2, TP53, CDKN2A
365fluorouracil448.9TP53, MDM2, CDKN2A
37agar448.9LGALS3, CDKN2A, MDM2
38paclitaxel44 50 1110.8TP53, MDM2, CDKN2A
39doxorubicin44 50 1110.8MDM2, TP53, CDKN2A
40actinomycin d448.8MDM2, CDKN2A, TP53
41paraffin448.4TP53, CDKN2A, MDM2, LGALS3
42cisplatin44 50 61 1111.4TP53, LGALS3, MDM2, CDKN2A
43progesterone44 28 61 24 1112.4LGALS3, MDM2, CDKN2A, TP53
44h2o2448.4MDM2, LGALS3, CDKN2A, TP53
45oligonucleotide448.4TP53, CDKN2A, LGALS3, MDM2
46cycloheximide448.4TP53, MDM2, CDKN2A
47vegf448.4CDKN2A, MDM2, LGALS3, TP53
48arginine448.4CDKN2A, LGALS3, TP53, MDM2
49estrogen448.4CDKN2A, MDM2, LGALS3, TP53
50serine448.3TP53, LGALS3, CDKN2A, MDM2

GO Terms for genes affiliated with Adult Astrocytic Tumour

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Cellular components related to Adult Astrocytic Tumour according to GeneCards/GeneDecks:

idNameGO IDScoreTop Affiliating Genes
1nuclear bodyGO:0166048.5CDKN2A, MDM2, TP53
2protein complexGO:0432348.4CDKN2A, MDM2, TP53
3nucleoplasmGO:0056548.2TP53, MDM2, CDKN2A
4cytoplasmGO:0057378.0CDKN2A, MDM2, LGALS3, TP53

Biological processes related to Adult Astrocytic Tumour according to GeneCards/GeneDecks:

(show all 11)
idNameGO IDScoreTop Affiliating Genes
1response to antibioticGO:0466779.5TP53, MDM2
2DNA damage response, signal transduction by p53 class mediator resulting in cell cycle arrestGO:0069779.4TP53, MDM2
3replicative senescenceGO:0903999.4CDKN2A, TP53
4positive regulation of cell cycle arrestGO:0711589.4CDKN2A, TP53
5cellular response to hypoxiaGO:0714569.3MDM2, TP53
6protein destabilizationGO:0316489.2CDKN2A, MDM2
7protein complex assemblyGO:0064619.2TP53, MDM2
8Ras protein signal transductionGO:0072659.2CDKN2A, TP53
9cell cycle arrestGO:0070509.1CDKN2A, TP53
10negative regulation of cell growthGO:0303088.8CDKN2A, TP53
11negative regulation of transcription, DNA-templatedGO:0458928.7CDKN2A, MDM2, TP53

Molecular functions related to Adult Astrocytic Tumour according to GeneCards/GeneDecks:

idNameGO IDScoreTop Affiliating Genes
1ubiquitin protein ligase bindingGO:0316259.3MDM2, TP53
2MDM2/MDM4 family protein bindingGO:0973718.8CDKN2A, TP53
3p53 bindingGO:0020398.4CDKN2A, MDM2, TP53

Products for genes affiliated with Adult Astrocytic Tumour

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Sources for Adult Astrocytic Tumour

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3CDC
13ExPASy
14FMA
22GTR
23HGMD
24HMDB
25ICD10
26ICD10 via Orphanet
27ICD9CM
28IUPHAR
29KEGG
34MeSH
35MESH via Orphanet
36MGI
39NCIt
40NDF-RT
43NINDS
44Novoseek
46OMIM
47OMIM via Orphanet
51PubMed
52QIAGEN
58SNOMED-CT via Orphanet
62UMLS
63UMLS via Orphanet