MCID: ADL053
MIFTS: 37

Adult Astrocytic Tumour malady

Cancer diseases category

Summaries for Adult Astrocytic Tumour

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MalaCards based summary: Adult Astrocytic Tumour, also known as adult astrocytoma, is related to astrocytoma and actinic keratosis. An important gene associated with Adult Astrocytic Tumour is LGALS3 (lectin, galactoside-binding, soluble, 3), and among its related pathways are Spinal Cord Injury and Glucocorticoid receptor regulatory network. The compounds 10-hydroxycamptothecin and bpde have been mentioned in the context of this disorder. Related mouse phenotypes are renal/urinary system and pigmentation.

Aliases & Classifications for Adult Astrocytic Tumour

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Adult Astrocytic Tumour, Aliases & Descriptions:

Name: Adult Astrocytic Tumour 9
Adult Astrocytoma 9 61
 
Adult Astrocytic Tumors 61


Classifications:

Malacards categories (disease lists): (See all malacards categories)
Global: Cancer diseases


External Ids:

Disease Ontology9 DOID:3076
NCIt39 C7049

Related Diseases for Adult Astrocytic Tumour

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Diseases related to Adult Astrocytic Tumour via text searches within MalaCards or GeneCards/GeneDecks gene sharing:

(show top 50)    (show all 57)
idRelated DiseaseScoreTop Affiliating Genes
1astrocytoma29.8TP53, LGALS3, MDM2, CDKN2A
2actinic keratosis10.4TP53
3giant cell glioblastoma10.4MDM2
4thyroid cancer, anaplastic10.2LGALS3, TP53
5breast cancer, invasive ductal10.2MDM2, TP53
6liposarcoma10.1MDM2, TP53
7cholangiocarcinoma10.1TP53, LGALS3
8basal cell carcinoma10.1LGALS3, TP53
9leiomyosarcoma10.1MDM2, TP53
10thyroid hurthle cell carcinoma10.1LGALS3, TP53
11li-fraumeni syndrome10.1CDKN2A, TP53
12oropharyngeal cancer, adult10.1TP53, CDKN2A
13ataxia telangiectasia10.1MDM2, TP53
14nasopharynx carcinoma10.1TP53, CDKN2A
15transitional cell carcinoma10.1TP53, MDM2
16barrett's esophagus10.0CDKN2A, TP53
17bladder carcinoma in situ10.0CDKN2A, TP53
18rhabdomyosarcoma10.0MDM2, TP53
19laryngeal squamous cell carcinoma10.0TP53, CDKN2A
20esophageal cancer10.0CDKN2A, TP53
21papilloma10.0TP53, CDKN2A
22malignant peripheral nerve sheath tumor10.0CDKN2A, MDM2
23uveal melanoma10.0CDKN2A, MDM2
24squamous cell carcinoma of the head and neck10.0CDKN2A, TP53
25multiple myeloma10.0TP53, CDKN2A
26acute lymphoblastic leukemia, childhood10.0CDKN2A, MDM2
27breast cancer9.9MDM2, LGALS3, TP53
28lung small cell carcinoma9.9CDKN2A, TP53
29lung adenocarcinoma9.8CDKN2A, TP53
30pancreatic cancer9.8TP53, LGALS3, CDKN2A
31anaplastic oligodendroglioma9.8LGALS3, MDM2, CDKN2A
32oral cancer9.8CDKN2A, MDM2, TP53
33adenoma9.8TP53, LGALS3, CDKN2A
34glioblastoma multiforme9.8CDKN2A, MDM2, TP53
35lung benign neoplasm9.8CDKN2A, MDM2, TP53
36b-cell lymphomas9.8CDKN2A, MDM2, TP53
37malignant glioma9.8CDKN2A, MDM2, TP53
38cervical cancer9.8TP53, MDM2, CDKN2A
39bladder carcinoma9.8CDKN2A, MDM2, TP53
40osteosarcoma9.8TP53, MDM2, CDKN2A
41prostate cancer9.8MDM2, LGALS3, TP53
42retinoblastoma9.8TP53, MDM2, CDKN2A
43non-small cell lung carcinoma9.8CDKN2A, MDM2, TP53
44ovarian cancer9.8CDKN2A, MDM2, TP53
45endometrial carcinoma9.8CDKN2A, TP53
46liver cancer9.7CDKN2A, MDM2, TP53
47lung cancer9.7CDKN2A, MDM2, TP53
48leukemia9.6TP53, MDM2, CDKN2A
49grade iii astrocytoma9.6CDKN2A, MDM2, LGALS3, TP53
50oligodendroglioma9.6TP53, LGALS3, MDM2, CDKN2A

Graphical network of the top 20 diseases related to Adult Astrocytic Tumour:



Diseases related to adult astrocytic tumour

Symptoms for Adult Astrocytic Tumour

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Drugs & Therapeutics for Adult Astrocytic Tumour

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Drug clinical trials:

Search ClinicalTrials for Adult Astrocytic Tumour

Search NIH Clinical Center for Adult Astrocytic Tumour

Genetic Tests for Adult Astrocytic Tumour

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Anatomical Context for Adult Astrocytic Tumour

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Animal Models for Adult Astrocytic Tumour or affiliated genes

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Publications for Adult Astrocytic Tumour

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Articles related to Adult Astrocytic Tumour:

idTitleAuthorsYear
1
p53-independent mechanisms regulate the P2-MDM2 promoter in adult astrocytic tumours. (18781178)
2008
2
Galectin-3 and galectin-3-binding site expression in human adult astrocytic tumours and related angiogenesis. (10476049)
1999

Variations for Adult Astrocytic Tumour

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Expression for genes affiliated with Adult Astrocytic Tumour

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Expression patterns in normal tissues for genes affiliated with Adult Astrocytic Tumour

Search GEO for disease gene expression data for Adult Astrocytic Tumour.

Pathways for genes affiliated with Adult Astrocytic Tumour

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Pathways related to Adult Astrocytic Tumour according to GeneCards/GeneDecks:

(show all 47)
idSuper pathways (with members indented)ScoreTop Affiliating Genes
19.4LGALS3, TP53
29.3TP53, MDM2
3
Show member pathways
Immune response IL 4 signaling pathway59
Signal transduction AKT signaling59
9.3TP53, MDM2
4
Show member pathways
9.3TP53, MDM2
5
Show member pathways
9.3TP53, MDM2
69.3TP53, MDM2
7
Show member pathways
Prostate Cancer37
Integrated Cancer pathway37
Steroid Biosynthesis37
9.3TP53, MDM2
89.3MDM2, TP53
9
Show member pathways
ATM Signaling Pathway37
9.3MDM2, TP53
109.3MDM2, TP53
11
Show member pathways
p53 pathway37
9.3MDM2, TP53
129.3MDM2, TP53
139.3MDM2, TP53
14
Show member pathways
DNA damage Role of SUMO in p53 regulation59
9.3MDM2, TP53
15
Show member pathways
ErbB receptor signaling network37
ErbB signaling pathway37
9.3MDM2, TP53
16
Show member pathways
9.3MDM2, TP53
179.3MDM2, TP53
189.3MDM2, TP53
199.3MDM2, TP53
209.3MDM2, TP53
219.3MDM2, TP53
22
Show member pathways
Signal transduction PTEN pathway59
9.3MDM2, TP53
239.3MDM2, TP53
24
Show member pathways
9.1TP53, CDKN2A
25
Show member pathways
8.5TP53, MDM2, CDKN2A
26
Show member pathways
8.5TP53, MDM2, CDKN2A
27
Show member pathways
8.5TP53, MDM2, CDKN2A
28
Show member pathways
DNA damage response (only ATM dependent)37
Wnt Signaling Pathway and Pluripotency37
8.5TP53, MDM2, CDKN2A
29
Show member pathways
8.5TP53, MDM2, CDKN2A
30
Show member pathways
Apoptosis Modulation and Signaling37
Apoptosis37
8.5TP53, MDM2, CDKN2A
318.5TP53, MDM2, CDKN2A
328.5TP53, MDM2, CDKN2A
338.5TP53, MDM2, CDKN2A
348.5TP53, MDM2, CDKN2A
358.5CDKN2A, MDM2, TP53
368.5CDKN2A, MDM2, TP53
378.5CDKN2A, MDM2, TP53
388.5CDKN2A, MDM2, TP53
39
Show member pathways
DNA damage response37
8.5CDKN2A, MDM2, TP53
40
Show member pathways
8.5CDKN2A, MDM2, TP53
418.5CDKN2A, MDM2, TP53
42
Show member pathways
8.5CDKN2A, MDM2, TP53
43
Show member pathways
8.5CDKN2A, MDM2, TP53
44
Show member pathways
8.5CDKN2A, MDM2, TP53
45
Show member pathways
8.5CDKN2A, MDM2, TP53
46
Show member pathways
Signaling Pathways in Glioblastoma37
8.5CDKN2A, MDM2, TP53
47
Show member pathways
Cell cycle37
8.5CDKN2A, MDM2, TP53

Compounds for genes affiliated with Adult Astrocytic Tumour

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Compounds related to Adult Astrocytic Tumour according to GeneCards/GeneDecks:

(show top 50)    (show all 78)
idCompoundScoreTop Affiliating Genes
110-hydroxycamptothecin449.7MDM2, TP53
2bpde449.7TP53, MDM2
3chlorambucil44 1210.7MDM2, TP53
4acnu449.5CDKN2A, TP53
5hpvs449.5TP53, CDKN2A
6noxa449.5MDM2, TP53
7olomoucine44 1210.4CDKN2A, TP53
85-methylcytosine44 2510.4CDKN2A, TP53
9temozolomide44 1210.4TP53, CDKN2A
107,12-dimethylbenz(a)anthracene449.4MDM2, CDKN2A
11hmba449.4CDKN2A, TP53
12o6-methylguanine449.4CDKN2A, TP53
13bcnu449.3CDKN2A, TP53
142-chlorodeoxyadenosine449.3TP53, MDM2
15methylmethanesulfonate449.3MDM2, TP53
16dutp449.3MDM2, LGALS3, TP53
17leptomycin b44 6010.3TP53, LGALS3, MDM2
18crcs449.2TP53, CDKN2A
19etoposide44 50 60 1212.2MDM2, LGALS3, TP53
20p00001449.1CDKN2A, MDM2
21proline449.0TP53, LGALS3, MDM2
22aflatoxin b144 2510.0CDKN2A, MDM2, TP53
23butyrate449.0CDKN2A, LGALS3, TP53
24roscovitine449.0CDKN2A, MDM2, TP53
25flavopiridol44 129.9CDKN2A, MDM2, TP53
26irinotecan44 50 1210.9TP53, MDM2, CDKN2A
27thymidylate448.9CDKN2A, MDM2, TP53
28vincristine44 50 1210.9TP53, MDM2, CDKN2A
29adriamycin448.9TP53, MDM2, CDKN2A
30camptothecin44 60 1210.9CDKN2A, MDM2, TP53
31docetaxel44 50 60 1211.9CDKN2A, MDM2, TP53
32mg 13244 609.9TP53, MDM2, CDKN2A
335-aza-2deoxycytidine448.9TP53, MDM2, CDKN2A
34arsenite44 259.9CDKN2A, MDM2, TP53
355fluorouracil448.9TP53, MDM2, CDKN2A
36agar448.9CDKN2A, MDM2, LGALS3
37paclitaxel44 50 1210.8CDKN2A, MDM2, TP53
38depsipeptide448.8CDKN2A, TP53
39doxorubicin44 50 1210.8TP53, MDM2, CDKN2A
40actinomycin d448.8CDKN2A, MDM2, TP53
41paraffin448.4TP53, LGALS3, MDM2, CDKN2A
42cisplatin44 50 60 1211.4TP53, LGALS3, MDM2, CDKN2A
43progesterone44 29 60 25 1212.4TP53, LGALS3, MDM2, CDKN2A
44h2o2448.4CDKN2A, MDM2, LGALS3, TP53
45oligonucleotide448.4TP53, LGALS3, MDM2, CDKN2A
46cycloheximide448.4CDKN2A, MDM2, TP53
47vegf448.4TP53, LGALS3, MDM2, CDKN2A
48arginine448.4CDKN2A, MDM2, LGALS3, TP53
49estrogen448.4CDKN2A, MDM2, LGALS3, TP53
50serine448.3CDKN2A, MDM2, LGALS3, TP53

GO Terms for genes affiliated with Adult Astrocytic Tumour

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Cellular components related to Adult Astrocytic Tumour according to GeneCards/GeneDecks:

idNameGO IDScoreTop Affiliating Genes
1nuclear bodyGO:0166048.5CDKN2A, MDM2, TP53
2protein complexGO:0432348.4CDKN2A, MDM2, TP53
3nucleoplasmGO:0056548.2TP53, MDM2, CDKN2A
4cytoplasmGO:0057378.0CDKN2A, MDM2, LGALS3, TP53

Biological processes related to Adult Astrocytic Tumour according to GeneCards/GeneDecks:

(show all 11)
idNameGO IDScoreTop Affiliating Genes
1response to antibioticGO:0466779.5TP53, MDM2
2DNA damage response, signal transduction by p53 class mediator resulting in cell cycle arrestGO:0069779.4TP53, MDM2
3replicative senescenceGO:0903999.4CDKN2A, TP53
4positive regulation of cell cycle arrestGO:0711589.4CDKN2A, TP53
5cellular response to hypoxiaGO:0714569.3MDM2, TP53
6protein destabilizationGO:0316489.2CDKN2A, MDM2
7protein complex assemblyGO:0064619.2TP53, MDM2
8Ras protein signal transductionGO:0072659.2CDKN2A, TP53
9cell cycle arrestGO:0070509.1CDKN2A, TP53
10negative regulation of cell growthGO:0303088.8CDKN2A, TP53
11negative regulation of transcription, DNA-templatedGO:0458928.7CDKN2A, MDM2, TP53

Molecular functions related to Adult Astrocytic Tumour according to GeneCards/GeneDecks:

idNameGO IDScoreTop Affiliating Genes
1ubiquitin protein ligase bindingGO:0316259.3MDM2, TP53
2MDM2/MDM4 family protein bindingGO:0973718.8CDKN2A, TP53
3p53 bindingGO:0020398.4CDKN2A, MDM2, TP53

Products for genes affiliated with Adult Astrocytic Tumour

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Sources for Adult Astrocytic Tumour

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4CDC
14ExPASy
15FMA
23GTR
24HGMD
25HMDB
26ICD10
27ICD10 via Orphanet
28ICD9CM
29IUPHAR
30KEGG
34MeSH
35MESH via Orphanet
36MGI
39NCIt
40NDF-RT
43NINDS
44Novoseek
46OMIM
47OMIM via Orphanet
51PubMed
52QIAGEN
57SNOMED-CT via Orphanet
61UMLS
62UMLS via Orphanet