MCID: ADL053
MIFTS: 38

Adult Astrocytic Tumour malady

Cancer diseases category

Summaries for Adult Astrocytic Tumour

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34MalaCards
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MalaCards: Adult Astrocytic Tumour, also known as adult astrocytic tumors, is related to astrocytoma and actinic keratosis. An important gene associated with Adult Astrocytic Tumour is LGALS3 (lectin, galactoside-binding, soluble, 3), and among its related pathways are Spinal Cord Injury and Glucocorticoid receptor regulatory network. The compounds 10-hydroxycamptothecin and bpde have been mentioned in the context of this disorder. Related mouse phenotypes are renal/urinary system and pigmentation.

Aliases & Classifications for Adult Astrocytic Tumour

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Sources:
9Disease Ontology, 63UMLS, 41NCIt
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Classifications:

Malacards categories (disease lists): (See all malacards categories)
Global: Cancer diseases


Aliases & Descriptions:

adult astrocytic tumour 9
adult astrocytic tumors 63
adult astrocytoma 9


External Ids:

Disease Ontology9 DOID:3076
NCIt41 C7049

Related Diseases for Adult Astrocytic Tumour

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Sources:
18GeneCards, 19GeneDecks
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Diseases related to Adult Astrocytic Tumour via text searches within MalaCards or GeneCards/GeneDecks gene sharing:

(show top 50)    (show all 56)
idRelated DiseaseScoreTop Affiliating Genes
1astrocytoma30.2TP53, LGALS3, MDM2, CDKN2A
2actinic keratosis10.1TP53
3giant cell glioblastoma10.1MDM2
4thyroid cancer, anaplastic10.0TP53, LGALS3
5breast cancer, invasive ductal10.0MDM2, TP53
6liposarcoma10.0TP53, MDM2
7cholangiocarcinoma10.0LGALS3, TP53
8basal cell carcinoma10.0TP53, LGALS3
9leiomyosarcoma10.0TP53, MDM2
10thyroid cancer10.0TP53, LGALS3
11li-fraumeni syndrome10.0TP53, CDKN2A
12oropharyngeal cancer, adult10.0CDKN2A, TP53
13ataxia telangiectasia10.0MDM2, TP53
14nasopharynx carcinoma10.0CDKN2A, TP53
15transitional cell carcinoma10.0TP53, MDM2
16barrett's esophagus10.0CDKN2A, TP53
17bladder carcinoma in situ10.0CDKN2A, TP53
18rhabdomyosarcoma10.0TP53, MDM2
19laryngeal squamous cell carcinoma10.0TP53, CDKN2A
20esophageal cancer10.0TP53, CDKN2A
21papilloma10.0CDKN2A, TP53
22malignant peripheral nerve sheath tumor10.0MDM2, CDKN2A
23intraocular melanoma10.0CDKN2A, MDM2
24multiple myeloma10.0TP53, CDKN2A
25acute lymphoblastic leukemia, childhood10.0MDM2, CDKN2A
26breast cancer10.0LGALS3, TP53, MDM2
27lung small cell carcinoma10.0TP53, CDKN2A
28squamous cell carcinoma of the head and neck10.0LGALS3, TP53, CDKN2A
29lung adenocarcinoma10.0TP53, CDKN2A
30pancreatic cancer10.0CDKN2A, LGALS3, TP53
31anaplastic oligodendroglioma10.0LGALS3, MDM2, CDKN2A
32oral cancer10.0CDKN2A, MDM2, TP53
33adenoma10.0LGALS3, TP53, CDKN2A
34glioblastoma multiforme10.0TP53, CDKN2A, MDM2
35lung benign neoplasm10.0MDM2, TP53, CDKN2A
36b-cell lymphomas10.0CDKN2A, MDM2, TP53
37malignant glioma9.9TP53, MDM2, CDKN2A
38cervical cancer9.9TP53, MDM2, CDKN2A
39bladder carcinoma9.9CDKN2A, MDM2, TP53
40osteosarcoma9.9TP53, MDM2, CDKN2A
41prostate cancer9.9LGALS3, TP53, MDM2
42retinoblastoma9.9MDM2, CDKN2A, TP53
43non-small cell lung carcinoma9.9MDM2, TP53, CDKN2A
44ovarian cancer9.9MDM2, CDKN2A, TP53
45endometrial carcinoma9.9CDKN2A, TP53
46hepatocellular carcinoma9.9CDKN2A, MDM2, TP53
47lung cancer9.9CDKN2A, TP53, MDM2
48leukemia9.9TP53, CDKN2A, MDM2
49anaplastic astrocytoma9.9LGALS3, CDKN2A, MDM2, TP53
50oligodendroglioma9.9MDM2, CDKN2A, LGALS3, TP53

Graphical network of the top 20 diseases related to Adult Astrocytic Tumour:



Diseases related to adult astrocytic tumour

Symptoms for Adult Astrocytic Tumour

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Drugs & Therapeutics for Adult Astrocytic Tumour

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Sources:
6CenterWatch, 43NIH Clinical Center, 7ClinicalTrials
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Approved drugs:

Search CenterWatch for Adult Astrocytic Tumour

Drug clinical trials:

Search ClinicalTrials for Adult Astrocytic Tumour

Search NIH Clinical Center for Adult Astrocytic Tumour

Search CenterWatch for Adult Astrocytic Tumour

Genetic Tests for Adult Astrocytic Tumour

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Anatomical Context for Adult Astrocytic Tumour

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Animal Models for Adult Astrocytic Tumour or affiliated genes

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38MGI
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Publications for Adult Astrocytic Tumour

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53PubMed
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Articles related to Adult Astrocytic Tumour:

idTitleAuthorsYear
1
p53-independent mechanisms regulate the P2-MDM2 promoter in adult astrocytic tumours. (18781178)
2008
2
Galectin-3 and galectin-3-binding site expression in human adult astrocytic tumours and related angiogenesis. (10476049)
1999

Variations for Adult Astrocytic Tumour

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Expression for genes affiliated with Adult Astrocytic Tumour

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Sources:
2BioGPS, 16Gene Expression Omnibus DataSets
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Expression patterns in normal tissues for genes affiliated with Adult Astrocytic Tumour

Search GEO for disease gene expression data for Adult Astrocytic Tumour.

Pathways for genes affiliated with Adult Astrocytic Tumour

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Sources:
51PathCards, 39NCBI BioSystems Database, 61Thomson Reuters, 13EMD Millipore, 54QIAGEN, 58SinoBiological, 31KEGG, 55R&D Systems, 52PharmGKB, 62Tocris Bioscience, 56Reactome, 5Cell Signaling Technology
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Pathways related to Adult Astrocytic Tumour according to GeneCards/GeneDecks:

(show all 47)
idSuper pathways (with members indented)ScoreTop Affiliating Genes
19.4LGALS3, TP53
29.3TP53, MDM2
3
Show member pathways
Immune response IL 4 signaling pathway61
Signal transduction AKT signaling61
9.3TP53, MDM2
4
Show member pathways
9.3TP53, MDM2
5
Show member pathways
9.3TP53, MDM2
69.3TP53, MDM2
7
Show member pathways
Prostate Cancer39
Integrated Cancer pathway39
Steroid Biosynthesis39
9.3TP53, MDM2
89.3MDM2, TP53
9
Show member pathways
ATM Signaling Pathway39
9.3MDM2, TP53
109.3MDM2, TP53
11
Show member pathways
p53 pathway39
9.3MDM2, TP53
129.3MDM2, TP53
139.3MDM2, TP53
14
Show member pathways
DNA damage Role of SUMO in p53 regulation61
9.3MDM2, TP53
15
Show member pathways
ErbB receptor signaling network39
ErbB signaling pathway39
9.3MDM2, TP53
16
Show member pathways
9.3MDM2, TP53
179.3MDM2, TP53
189.3MDM2, TP53
199.3MDM2, TP53
209.3MDM2, TP53
219.3MDM2, TP53
22
Show member pathways
Signal transduction PTEN pathway61
9.3MDM2, TP53
239.3MDM2, TP53
24
Show member pathways
9.1TP53, CDKN2A
25
Show member pathways
8.5TP53, MDM2, CDKN2A
26
Show member pathways
8.5TP53, MDM2, CDKN2A
27
Show member pathways
8.5TP53, MDM2, CDKN2A
28
Show member pathways
DNA damage response (only ATM dependent)39
Wnt Signaling Pathway and Pluripotency39
8.5TP53, MDM2, CDKN2A
29
Show member pathways
8.5TP53, MDM2, CDKN2A
30
Show member pathways
Apoptosis Modulation and Signaling39
Apoptosis39
8.5TP53, MDM2, CDKN2A
318.5TP53, MDM2, CDKN2A
328.5TP53, MDM2, CDKN2A
338.5TP53, MDM2, CDKN2A
348.5TP53, MDM2, CDKN2A
358.5CDKN2A, MDM2, TP53
368.5CDKN2A, MDM2, TP53
378.5CDKN2A, MDM2, TP53
388.5CDKN2A, MDM2, TP53
39
Show member pathways
DNA damage response39
8.5CDKN2A, MDM2, TP53
40
Show member pathways
8.5CDKN2A, MDM2, TP53
418.5CDKN2A, MDM2, TP53
42
Show member pathways
8.5CDKN2A, MDM2, TP53
43
Show member pathways
8.5CDKN2A, MDM2, TP53
44
Show member pathways
8.5CDKN2A, MDM2, TP53
45
Show member pathways
8.5CDKN2A, MDM2, TP53
46
Show member pathways
Signaling Pathways in Glioblastoma39
8.5CDKN2A, MDM2, TP53
47
Show member pathways
Cell cycle39
8.5CDKN2A, MDM2, TP53

Compounds for genes affiliated with Adult Astrocytic Tumour

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Sources:
46Novoseek, 12DrugBank, 25HMDB, 62Tocris Bioscience, 52PharmGKB, 30IUPHAR
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Compounds related to Adult Astrocytic Tumour according to GeneCards/GeneDecks:

(show top 50)    (show all 78)
idCompoundScoreTop Affiliating Genes
110-hydroxycamptothecin469.7MDM2, TP53
2bpde469.7TP53, MDM2
3chlorambucil46 1210.7MDM2, TP53
4acnu469.5CDKN2A, TP53
5hpvs469.5TP53, CDKN2A
6noxa469.5MDM2, TP53
7olomoucine46 1210.4CDKN2A, TP53
85-methylcytosine46 2510.4CDKN2A, TP53
9temozolomide46 1210.4TP53, CDKN2A
107,12-dimethylbenz(a)anthracene469.4MDM2, CDKN2A
11hmba469.4CDKN2A, TP53
12o6-methylguanine469.4CDKN2A, TP53
13bcnu469.3CDKN2A, TP53
142-chlorodeoxyadenosine469.3TP53, MDM2
15methylmethanesulfonate469.3MDM2, TP53
16dutp469.3MDM2, LGALS3, TP53
17leptomycin b46 6210.3TP53, LGALS3, MDM2
18crcs469.2TP53, CDKN2A
19etoposide46 52 62 1212.2MDM2, LGALS3, TP53
20p00001469.1CDKN2A, MDM2
21proline469.0TP53, LGALS3, MDM2
22aflatoxin b146 2510.0CDKN2A, MDM2, TP53
23butyrate469.0CDKN2A, LGALS3, TP53
24roscovitine469.0CDKN2A, MDM2, TP53
25flavopiridol46 129.9CDKN2A, MDM2, TP53
26irinotecan46 52 1210.9TP53, MDM2, CDKN2A
27thymidylate468.9CDKN2A, MDM2, TP53
28vincristine46 52 1210.9TP53, MDM2, CDKN2A
29adriamycin468.9TP53, MDM2, CDKN2A
30camptothecin46 62 1210.9CDKN2A, MDM2, TP53
31docetaxel46 52 62 1211.9CDKN2A, MDM2, TP53
32mg 13246 629.9TP53, MDM2, CDKN2A
335-aza-2deoxycytidine468.9TP53, MDM2, CDKN2A
34arsenite46 259.9CDKN2A, MDM2, TP53
355fluorouracil468.9TP53, MDM2, CDKN2A
36agar468.9CDKN2A, MDM2, LGALS3
37paclitaxel46 52 1210.8CDKN2A, MDM2, TP53
38depsipeptide468.8CDKN2A, TP53
39doxorubicin46 52 1210.8TP53, MDM2, CDKN2A
40actinomycin d468.8CDKN2A, MDM2, TP53
41paraffin468.4TP53, LGALS3, MDM2, CDKN2A
42cisplatin46 52 62 1211.4TP53, LGALS3, MDM2, CDKN2A
43progesterone46 30 62 25 1212.4TP53, LGALS3, MDM2, CDKN2A
44h2o2468.4CDKN2A, MDM2, LGALS3, TP53
45oligonucleotide468.4TP53, LGALS3, MDM2, CDKN2A
46cycloheximide468.4CDKN2A, MDM2, TP53
47vegf468.4TP53, LGALS3, MDM2, CDKN2A
48arginine468.4CDKN2A, MDM2, LGALS3, TP53
49estrogen468.4CDKN2A, MDM2, LGALS3, TP53
50serine468.3CDKN2A, MDM2, LGALS3, TP53

GO Terms for genes affiliated with Adult Astrocytic Tumour

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17Gene Ontology
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Cellular components related to Adult Astrocytic Tumour according to GeneCards/GeneDecks:

idNameGO IDScoreTop Affiliating Genes
1nuclear bodyGO:0166048.5CDKN2A, MDM2, TP53
2protein complexGO:0432348.4CDKN2A, MDM2, TP53
3nucleoplasmGO:0056548.2TP53, MDM2, CDKN2A
4cytoplasmGO:0057378.0CDKN2A, MDM2, LGALS3, TP53

Biological processes related to Adult Astrocytic Tumour according to GeneCards/GeneDecks:

(show all 11)
idNameGO IDScoreTop Affiliating Genes
1response to antibioticGO:0466779.5TP53, MDM2
2DNA damage response, signal transduction by p53 class mediator resulting in cell cycle arrestGO:0069779.4TP53, MDM2
3replicative senescenceGO:0903999.4CDKN2A, TP53
4positive regulation of cell cycle arrestGO:0711589.4CDKN2A, TP53
5cellular response to hypoxiaGO:0714569.3MDM2, TP53
6protein destabilizationGO:0316489.2CDKN2A, MDM2
7protein complex assemblyGO:0064619.2TP53, MDM2
8Ras protein signal transductionGO:0072659.2CDKN2A, TP53
9cell cycle arrestGO:0070509.1CDKN2A, TP53
10negative regulation of cell growthGO:0303088.8CDKN2A, TP53
11negative regulation of transcription, DNA-templatedGO:0458928.7CDKN2A, MDM2, TP53

Molecular functions related to Adult Astrocytic Tumour according to GeneCards/GeneDecks:

idNameGO IDScoreTop Affiliating Genes
1ubiquitin protein ligase bindingGO:0316259.3MDM2, TP53
2MDM2/MDM4 family protein bindingGO:0973718.8CDKN2A, TP53
3p53 bindingGO:0020398.4CDKN2A, MDM2, TP53

Products for genes affiliated with Adult Astrocytic Tumour

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  • Antibodies
  • Proteins
  • Lysates
  • Antibodies

Sources for Adult Astrocytic Tumour

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4CDC
14ExPASy
15FMA
23GTR
24HGMD
25HMDB
26ICD10
27ICD10 via Orphanet
28ICD9CM
30IUPHAR
31KEGG
36MeSH
37MESH via Orphanet
38MGI
41NCIt
42NDF-RT
45NINDS
46Novoseek
48OMIM
49OMIM via Orphanet
53PubMed
54QIAGEN
60SNOMED-CT via Orphanet
63UMLS
64UMLS via Orphanet