MCID: ADL053
MIFTS: 31

Adult Astrocytic Tumour malady

Cancer diseases category

Aliases & Classifications for Adult Astrocytic Tumour

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Aliases & Descriptions for Adult Astrocytic Tumour:

Name: Adult Astrocytic Tumour 8
Adult Astrocytic Tumors 61
 
Adult Astrocytoma 8


Classifications:



External Ids:

Disease Ontology8 DOID:3076
NCIt39 C7049

Summaries for Adult Astrocytic Tumour

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MalaCards based summary: Adult Astrocytic Tumour, also known as adult astrocytic tumors, is related to astrocytoma and oligodendroglioma. An important gene associated with Adult Astrocytic Tumour is LGALS3 (lectin, galactoside-binding, soluble, 3), and among its related pathways are Spinal Cord Injury and ErbB signaling pathway. The compounds 10-hydroxycamptothecin and bpde have been mentioned in the context of this disorder. Related mouse phenotypes are renal/urinary system and pigmentation.

Related Diseases for Adult Astrocytic Tumour

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Diseases related to Adult Astrocytic Tumour via text searches within MalaCards or GeneCards Suite gene sharing:

(show top 50)    (show all 54)
idRelated DiseaseScoreTop Affiliating Genes
1astrocytoma29.9TP53, LGALS3, MDM2, CDKN2A
2oligodendroglioma29.4MDM2, CDKN2A, LGALS3, TP53
3glioblastoma29.4LGALS3, CDKN2A, MDM2, TP53
4actinic keratosis10.4TP53
5giant cell glioblastoma10.4MDM2
6thyroid cancer, anaplastic10.2TP53, LGALS3
7liposarcoma10.1TP53, MDM2
8cholangiocarcinoma10.1LGALS3, TP53
9basal cell carcinoma10.1TP53, LGALS3
10leiomyosarcoma10.1TP53, MDM2
11thyroid cancer10.1TP53, LGALS3
12li-fraumeni syndrome10.1TP53, CDKN2A
13oropharynx cancer10.1CDKN2A, TP53
14ataxia-telangiectasia10.1MDM2, TP53
15nasopharynx carcinoma10.1CDKN2A, TP53
16transitional cell carcinoma10.0TP53, MDM2
17barrett esophagus/esophageal adenocarcinoma10.0CDKN2A, TP53
18bladder cancer, somatic10.0CDKN2A, TP53
19rhabdomyosarcoma10.0TP53, MDM2
20laryngeal squamous cell carcinoma10.0TP53, CDKN2A
21esophageal cancer10.0TP53, CDKN2A
22papilloma10.0CDKN2A, TP53
23malignant peripheral nerve sheath tumor10.0MDM2, CDKN2A
24uveal melanoma10.0CDKN2A, MDM2
25squamous cell carcinoma, head and neck10.0CDKN2A, TP53
26multiple myeloma10.0TP53, CDKN2A
27acute lymphoblastic leukemia, childhood10.0MDM2, CDKN2A
28breast cancer9.9LGALS3, TP53, MDM2
29small cell cancer of the lung, somatic9.9TP53, CDKN2A
30lung cancer susceptibility 39.8TP53, CDKN2A
31pancreatic cancer9.8CDKN2A, LGALS3, TP53
32anaplastic oligodendroglioma9.8LGALS3, MDM2, CDKN2A
33oral cancer9.8CDKN2A, MDM2, TP53
34nasopharyngeal carcinoma9.8TP53, MDM2, CDKN2A
35adenoma9.8LGALS3, TP53, CDKN2A
36glioblastoma multiforme9.8TP53, CDKN2A, MDM2
37lung benign neoplasm9.8MDM2, TP53, CDKN2A
38b-cell lymphomas9.8CDKN2A, MDM2, TP53
39malignant glioma9.8TP53, MDM2, CDKN2A
40cervical cancer, somatic9.8TP53, MDM2, CDKN2A
41osteosarcoma, somatic9.8TP53, MDM2, CDKN2A
42prostate cancer9.8LGALS3, TP53, MDM2
43retinoblastoma9.8MDM2, CDKN2A, TP53
44ovarian cancer, somatic9.7MDM2, CDKN2A, TP53
45endometrial cancer9.7CDKN2A, TP53
46hepatocellular carcinoma9.7CDKN2A, MDM2, TP53
47lung cancer9.7CDKN2A, TP53, MDM2
48leukemia9.6TP53, CDKN2A, MDM2
49grade iii astrocytoma9.6LGALS3, CDKN2A, MDM2, TP53
50burkitt lymphoma9.6LGALS3, MDM2, CDKN2A, TP53

Graphical network of the top 20 diseases related to Adult Astrocytic Tumour:



Diseases related to adult astrocytic tumour

Symptoms for Adult Astrocytic Tumour

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Drugs & Therapeutics for Adult Astrocytic Tumour

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Drug clinical trials:

Search ClinicalTrials for Adult Astrocytic Tumour

Search NIH Clinical Center for Adult Astrocytic Tumour

Genetic Tests for Adult Astrocytic Tumour

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Anatomical Context for Adult Astrocytic Tumour

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Animal Models for Adult Astrocytic Tumour or affiliated genes

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Publications for Adult Astrocytic Tumour

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Articles related to Adult Astrocytic Tumour:

idTitleAuthorsYear
1
p53-independent mechanisms regulate the P2-MDM2 promoter in adult astrocytic tumours. (18781178)
2008
2
Galectin-3 and galectin-3-binding site expression in human adult astrocytic tumours and related angiogenesis. (10476049)
1999

Variations for Adult Astrocytic Tumour

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Expression for genes affiliated with Adult Astrocytic Tumour

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Search GEO for disease gene expression data for Adult Astrocytic Tumour.

Pathways for genes affiliated with Adult Astrocytic Tumour

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Pathways related to Adult Astrocytic Tumour according to GeneCards Suite gene sharing:

(show all 47)
idSuper pathways (with members indented)ScoreTop Affiliating Genes
19.4TP53, LGALS3
2
Show member pathways
ErbB receptor signaling network36
ErbB signaling pathway36
9.3TP53, MDM2
39.3TP53, MDM2
4
Show member pathways
Prostate Cancer36
Integrated Cancer pathway36
Steroid Biosynthesis36
9.3TP53, MDM2
59.3TP53, MDM2
6
Show member pathways
p53 pathway36
9.3TP53, MDM2
79.3TP53, MDM2
8
Show member pathways
ATM Signaling Pathway36
9.3TP53, MDM2
9
Show member pathways
Signal transduction PTEN pathway59
9.3TP53, MDM2
10
Show member pathways
9.3TP53, MDM2
119.3TP53, MDM2
129.3TP53, MDM2
139.3TP53, MDM2
14
Show member pathways
9.3TP53, MDM2
159.3MDM2, TP53
16
Show member pathways
DNA damage Role of SUMO in p53 regulation59
9.3MDM2, TP53
179.3MDM2, TP53
189.3MDM2, TP53
199.3MDM2, TP53
20
Show member pathways
Development IGF RI signaling
Immune response IL 4 signaling pathway59
Signal transduction AKT signaling59
9.3MDM2, TP53
219.3MDM2, TP53
229.3MDM2, TP53
23
Show member pathways
9.3MDM2, TP53
24
Show member pathways
9.1TP53, CDKN2A
258.5TP53, MDM2, CDKN2A
26
Show member pathways
8.5TP53, MDM2, CDKN2A
27
Show member pathways
8.5TP53, MDM2, CDKN2A
28
Show member pathways
8.5MDM2, CDKN2A, TP53
29
Show member pathways
8.5CDKN2A, TP53, MDM2
30
Show member pathways
Apoptosis Modulation and Signaling36
Apoptosis36
8.5MDM2, CDKN2A, TP53
31
Show member pathways
Cell cycle36
8.5CDKN2A, MDM2, TP53
32
Show member pathways
8.5CDKN2A, TP53, MDM2
33
Show member pathways
DNA damage response36
8.5CDKN2A, TP53, MDM2
348.5CDKN2A, TP53, MDM2
358.5MDM2, CDKN2A, TP53
36
Show member pathways
8.5CDKN2A, MDM2, TP53
37
Show member pathways
DNA damage response (only ATM dependent)36
Wnt Signaling Pathway and Pluripotency36
8.5TP53, CDKN2A, MDM2
388.5TP53, CDKN2A, MDM2
39
Show member pathways
8.5CDKN2A, TP53, MDM2
40
Show member pathways
Signaling Pathways in Glioblastoma36
8.5CDKN2A, TP53, MDM2
41
Show member pathways
8.5CDKN2A, TP53, MDM2
428.5TP53, CDKN2A, MDM2
43
Show member pathways
8.5CDKN2A, TP53, MDM2
448.5MDM2, TP53, CDKN2A
458.5MDM2, TP53, CDKN2A
468.5MDM2, TP53, CDKN2A
478.5MDM2, TP53, CDKN2A

Compounds for genes affiliated with Adult Astrocytic Tumour

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Compounds related to Adult Astrocytic Tumour according to GeneCards Suite gene sharing:

(show top 50)    (show all 78)
idCompoundScoreTop Affiliating Genes
110-hydroxycamptothecin449.7MDM2, TP53
2bpde449.7TP53, MDM2
3chlorambucil44 1110.7TP53, MDM2
4acnu449.5TP53, CDKN2A
5hpvs449.5TP53, CDKN2A
6noxa449.5MDM2, TP53
75-methylcytosine44 2410.4CDKN2A, TP53
8olomoucine44 1110.4TP53, CDKN2A
92-chlorodeoxyadenosine449.4MDM2, TP53
10temozolomide44 1110.4CDKN2A, TP53
117,12-dimethylbenz(a)anthracene449.4MDM2, CDKN2A
12hmba449.4TP53, CDKN2A
13bcnu449.4TP53, CDKN2A
14o6-methylguanine449.3CDKN2A, TP53
15dutp449.3MDM2, TP53, LGALS3
16leptomycin b44 6010.3LGALS3, TP53, MDM2
17etoposide44 50 60 1112.2TP53, LGALS3, MDM2
18p00001449.1CDKN2A, MDM2
19crcs449.1CDKN2A, TP53
20depsipeptide449.1CDKN2A, TP53
21methylmethanesulfonate449.0TP53, MDM2
22proline449.0LGALS3, MDM2, TP53
23aflatoxin b144 2410.0TP53, CDKN2A, MDM2
24butyrate449.0CDKN2A, LGALS3, TP53
25roscovitine449.0CDKN2A, TP53, MDM2
26flavopiridol44 119.9CDKN2A, MDM2, TP53
27irinotecan44 50 1110.9TP53, MDM2, CDKN2A
28thymidylate448.9TP53, MDM2, CDKN2A
29vincristine44 50 1110.9MDM2, TP53, CDKN2A
30adriamycin448.9CDKN2A, TP53, MDM2
31camptothecin44 60 1110.9CDKN2A, TP53, MDM2
32docetaxel44 50 60 1111.9CDKN2A, MDM2, TP53
33mg 13244 609.9TP53, CDKN2A, MDM2
345-aza-2deoxycytidine448.9TP53, MDM2, CDKN2A
35arsenite44 249.9MDM2, TP53, CDKN2A
365fluorouracil448.9TP53, MDM2, CDKN2A
37agar448.9LGALS3, CDKN2A, MDM2
38paclitaxel44 50 1110.8TP53, MDM2, CDKN2A
39doxorubicin44 50 1110.8MDM2, TP53, CDKN2A
40actinomycin d448.8MDM2, CDKN2A, TP53
41paraffin448.4TP53, CDKN2A, MDM2, LGALS3
42cisplatin44 50 60 1111.4TP53, LGALS3, MDM2, CDKN2A
43progesterone44 28 60 24 1112.4LGALS3, MDM2, CDKN2A, TP53
44h2o2448.4MDM2, LGALS3, CDKN2A, TP53
45oligonucleotide448.4TP53, CDKN2A, LGALS3, MDM2
46cycloheximide448.4TP53, MDM2, CDKN2A
47vegf448.4CDKN2A, MDM2, LGALS3, TP53
48arginine448.4CDKN2A, LGALS3, TP53, MDM2
49estrogen448.4CDKN2A, MDM2, LGALS3, TP53
50serine448.3TP53, LGALS3, CDKN2A, MDM2

GO Terms for genes affiliated with Adult Astrocytic Tumour

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Cellular components related to Adult Astrocytic Tumour according to GeneCards Suite gene sharing:

idNameGO IDScoreTop Affiliating Genes
1nuclear bodyGO:00166048.5CDKN2A, MDM2, TP53
2protein complexGO:00432348.4CDKN2A, MDM2, TP53
3nucleoplasmGO:00056548.2TP53, MDM2, CDKN2A
4cytoplasmGO:00057378.0CDKN2A, MDM2, LGALS3, TP53

Biological processes related to Adult Astrocytic Tumour according to GeneCards Suite gene sharing:

(show all 11)
idNameGO IDScoreTop Affiliating Genes
1response to antibioticGO:00466779.5TP53, MDM2
2DNA damage response, signal transduction by p53 class mediator resulting in cell cycle arrestGO:00069779.4TP53, MDM2
3replicative senescenceGO:00903999.4CDKN2A, TP53
4positive regulation of cell cycle arrestGO:00711589.4CDKN2A, TP53
5cellular response to hypoxiaGO:00714569.3MDM2, TP53
6protein destabilizationGO:00316489.2CDKN2A, MDM2
7protein complex assemblyGO:00064619.2TP53, MDM2
8Ras protein signal transductionGO:00072659.2CDKN2A, TP53
9cell cycle arrestGO:00070509.1CDKN2A, TP53
10negative regulation of cell growthGO:00303088.8CDKN2A, TP53
11negative regulation of transcription, DNA-templatedGO:00458928.7CDKN2A, MDM2, TP53

Molecular functions related to Adult Astrocytic Tumour according to GeneCards Suite gene sharing:

idNameGO IDScoreTop Affiliating Genes
1ubiquitin protein ligase bindingGO:00316259.3MDM2, TP53
2MDM2/MDM4 family protein bindingGO:00973718.8CDKN2A, TP53
3p53 bindingGO:00020398.4CDKN2A, MDM2, TP53

Sources for Adult Astrocytic Tumour

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2CDC
12ExPASy
13FDA
14FMA
22GTR
23HGMD
24HMDB
25ICD10
26ICD10 via Orphanet
27ICD9CM
28IUPHAR
29KEGG
33MeSH
34MESH via Orphanet
35MGI
38NCI
39NCIt
40NDF-RT
43NINDS
44Novoseek
46OMIM
47OMIM via Orphanet
51PubMed
52QIAGEN
57SNOMED-CT via Orphanet
61UMLS
62UMLS via Orphanet