MCID: ADL053
MIFTS: 31

Adult Astrocytic Tumour malady

Cancer diseases category

Summaries for Adult Astrocytic Tumour

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MalaCards based summary: Adult Astrocytic Tumour, also known as adult astrocytic tumors, is related to astrocytoma and oligodendroglioma. An important gene associated with Adult Astrocytic Tumour is LGALS3 (lectin, galactoside-binding, soluble, 3), and among its related pathways are Spinal Cord Injury and Glucocorticoid receptor regulatory network. The compounds 10-hydroxycamptothecin and bpde have been mentioned in the context of this disorder. Related mouse phenotypes are renal/urinary system and pigmentation.

Aliases & Classifications for Adult Astrocytic Tumour

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Adult Astrocytic Tumour, Aliases & Descriptions:

Name: Adult Astrocytic Tumour 9
Adult Astrocytic Tumors 60
 
Adult Astrocytoma 9


Classifications:

Malacards categories (disease lists): (See all malacards categories)
Global: Cancer diseases


External Ids:

Disease Ontology9 DOID:3076
NCIt38 C7049

Related Diseases for Adult Astrocytic Tumour

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Diseases related to Adult Astrocytic Tumour via text searches within MalaCards or GeneCards Suite gene sharing:

(show top 50)    (show all 54)
idRelated DiseaseScoreTop Affiliating Genes
1astrocytoma29.9TP53, LGALS3, MDM2, CDKN2A
2oligodendroglioma29.4MDM2, CDKN2A, LGALS3, TP53
3glioblastoma29.4LGALS3, CDKN2A, MDM2, TP53
4actinic keratosis10.4TP53
5giant cell glioblastoma10.4MDM2
6thyroid cancer, anaplastic10.2TP53, LGALS3
7liposarcoma10.1TP53, MDM2
8cholangiocarcinoma10.1LGALS3, TP53
9basal cell carcinoma10.1TP53, LGALS3
10leiomyosarcoma10.1TP53, MDM2
11thyroid cancer10.1TP53, LGALS3
12li-fraumeni syndrome10.1TP53, CDKN2A
13oropharynx cancer10.1CDKN2A, TP53
14ataxia-telangiectasia10.1MDM2, TP53
15nasopharynx carcinoma10.1CDKN2A, TP53
16transitional cell carcinoma10.0TP53, MDM2
17barrett esophagus/esophageal adenocarcinoma10.0CDKN2A, TP53
18bladder cancer, somatic10.0CDKN2A, TP53
19rhabdomyosarcoma10.0TP53, MDM2
20laryngeal squamous cell carcinoma10.0TP53, CDKN2A
21esophageal cancer10.0TP53, CDKN2A
22papilloma10.0CDKN2A, TP53
23malignant peripheral nerve sheath tumor10.0MDM2, CDKN2A
24uveal melanoma10.0CDKN2A, MDM2
25squamous cell carcinoma, head and neck10.0CDKN2A, TP53
26multiple myeloma10.0TP53, CDKN2A
27acute lymphoblastic leukemia, childhood10.0MDM2, CDKN2A
28breast cancer9.9LGALS3, TP53, MDM2
29small cell cancer of the lung, somatic9.9TP53, CDKN2A
30lung cancer susceptibility 39.8TP53, CDKN2A
31pancreatic cancer9.8CDKN2A, LGALS3, TP53
32anaplastic oligodendroglioma9.8LGALS3, MDM2, CDKN2A
33oral cancer9.8CDKN2A, MDM2, TP53
34nasopharyngeal carcinoma9.8TP53, MDM2, CDKN2A
35adenoma9.8LGALS3, TP53, CDKN2A
36glioblastoma multiforme9.8TP53, CDKN2A, MDM2
37lung benign neoplasm9.8MDM2, TP53, CDKN2A
38b-cell lymphomas9.8CDKN2A, MDM2, TP53
39malignant glioma9.8TP53, MDM2, CDKN2A
40cervical cancer, somatic9.8TP53, MDM2, CDKN2A
41osteosarcoma, somatic9.8TP53, MDM2, CDKN2A
42prostate cancer9.8LGALS3, TP53, MDM2
43retinoblastoma9.8MDM2, CDKN2A, TP53
44ovarian cancer, somatic9.7MDM2, CDKN2A, TP53
45endometrial cancer9.7CDKN2A, TP53
46hepatocellular carcinoma9.7CDKN2A, MDM2, TP53
47lung cancer9.7CDKN2A, TP53, MDM2
48leukemia9.6TP53, CDKN2A, MDM2
49grade iii astrocytoma9.6LGALS3, CDKN2A, MDM2, TP53
50burkitt lymphoma9.6LGALS3, MDM2, CDKN2A, TP53

Graphical network of the top 20 diseases related to Adult Astrocytic Tumour:



Diseases related to adult astrocytic tumour

Symptoms for Adult Astrocytic Tumour

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Drugs & Therapeutics for Adult Astrocytic Tumour

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Drug clinical trials:

Search ClinicalTrials for Adult Astrocytic Tumour

Search NIH Clinical Center for Adult Astrocytic Tumour

Genetic Tests for Adult Astrocytic Tumour

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Anatomical Context for Adult Astrocytic Tumour

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Animal Models for Adult Astrocytic Tumour or affiliated genes

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Publications for Adult Astrocytic Tumour

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Articles related to Adult Astrocytic Tumour:

idTitleAuthorsYear
1
p53-independent mechanisms regulate the P2-MDM2 promoter in adult astrocytic tumours. (18781178)
2008
2
Galectin-3 and galectin-3-binding site expression in human adult astrocytic tumours and related angiogenesis. (10476049)
1999

Variations for Adult Astrocytic Tumour

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Expression for genes affiliated with Adult Astrocytic Tumour

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Search GEO for disease gene expression data for Adult Astrocytic Tumour.

Pathways for genes affiliated with Adult Astrocytic Tumour

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Pathways related to Adult Astrocytic Tumour according to GeneCards Suite gene sharing:

(show all 47)
idSuper pathways (with members indented)ScoreTop Affiliating Genes
19.4LGALS3, TP53
29.3TP53, MDM2
3
Show member pathways
Development IGF RI signaling
Immune response IL 4 signaling pathway58
Signal transduction AKT signaling58
9.3TP53, MDM2
4
Show member pathways
9.3TP53, MDM2
5
Show member pathways
9.3TP53, MDM2
69.3TP53, MDM2
7
Show member pathways
Prostate Cancer36
Integrated Cancer pathway36
Steroid Biosynthesis36
9.3TP53, MDM2
89.3MDM2, TP53
9
Show member pathways
ATM Signaling Pathway36
9.3MDM2, TP53
109.3MDM2, TP53
11
Show member pathways
p53 pathway36
9.3MDM2, TP53
129.3MDM2, TP53
139.3MDM2, TP53
14
Show member pathways
DNA damage Role of SUMO in p53 regulation58
9.3MDM2, TP53
15
Show member pathways
ErbB receptor signaling network36
ErbB signaling pathway36
9.3MDM2, TP53
16
Show member pathways
9.3MDM2, TP53
179.3MDM2, TP53
189.3MDM2, TP53
199.3MDM2, TP53
209.3MDM2, TP53
219.3MDM2, TP53
22
Show member pathways
Signal transduction PTEN pathway58
9.3MDM2, TP53
239.3MDM2, TP53
24
Show member pathways
9.1TP53, CDKN2A
25
Show member pathways
8.5TP53, MDM2, CDKN2A
26
Show member pathways
8.5TP53, MDM2, CDKN2A
27
Show member pathways
8.5TP53, MDM2, CDKN2A
28
Show member pathways
DNA damage response (only ATM dependent)36
Wnt Signaling Pathway and Pluripotency36
8.5TP53, MDM2, CDKN2A
29
Show member pathways
8.5TP53, MDM2, CDKN2A
30
Show member pathways
Apoptosis Modulation and Signaling36
Apoptosis36
8.5TP53, MDM2, CDKN2A
318.5TP53, MDM2, CDKN2A
328.5TP53, MDM2, CDKN2A
338.5TP53, MDM2, CDKN2A
348.5TP53, MDM2, CDKN2A
358.5CDKN2A, MDM2, TP53
368.5CDKN2A, MDM2, TP53
378.5CDKN2A, MDM2, TP53
388.5CDKN2A, MDM2, TP53
39
Show member pathways
DNA damage response36
8.5CDKN2A, MDM2, TP53
40
Show member pathways
8.5CDKN2A, MDM2, TP53
418.5CDKN2A, MDM2, TP53
42
Show member pathways
8.5CDKN2A, MDM2, TP53
43
Show member pathways
8.5CDKN2A, MDM2, TP53
44
Show member pathways
8.5CDKN2A, MDM2, TP53
45
Show member pathways
8.5CDKN2A, MDM2, TP53
46
Show member pathways
Signaling Pathways in Glioblastoma36
8.5CDKN2A, MDM2, TP53
47
Show member pathways
Cell cycle36
8.5CDKN2A, MDM2, TP53

Compounds for genes affiliated with Adult Astrocytic Tumour

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Compounds related to Adult Astrocytic Tumour according to GeneCards Suite gene sharing:

(show top 50)    (show all 78)
idCompoundScoreTop Affiliating Genes
110-hydroxycamptothecin439.7MDM2, TP53
2bpde439.7TP53, MDM2
3chlorambucil43 1210.7MDM2, TP53
4acnu439.5CDKN2A, TP53
5hpvs439.5TP53, CDKN2A
6noxa439.5MDM2, TP53
7olomoucine43 1210.4CDKN2A, TP53
85-methylcytosine43 2410.4CDKN2A, TP53
9temozolomide43 1210.4TP53, CDKN2A
107,12-dimethylbenz(a)anthracene439.4MDM2, CDKN2A
11hmba439.4CDKN2A, TP53
12o6-methylguanine439.4CDKN2A, TP53
13bcnu439.3CDKN2A, TP53
142-chlorodeoxyadenosine439.3TP53, MDM2
15methylmethanesulfonate439.3MDM2, TP53
16dutp439.3MDM2, LGALS3, TP53
17leptomycin b43 5910.3TP53, LGALS3, MDM2
18crcs439.2TP53, CDKN2A
19etoposide43 49 59 1212.2MDM2, LGALS3, TP53
20p00001439.1CDKN2A, MDM2
21proline439.0TP53, LGALS3, MDM2
22aflatoxin b143 2410.0CDKN2A, MDM2, TP53
23butyrate439.0CDKN2A, LGALS3, TP53
24roscovitine439.0CDKN2A, MDM2, TP53
25flavopiridol43 129.9CDKN2A, MDM2, TP53
26irinotecan43 49 1210.9TP53, MDM2, CDKN2A
27thymidylate438.9CDKN2A, MDM2, TP53
28vincristine43 49 1210.9TP53, MDM2, CDKN2A
29adriamycin438.9TP53, MDM2, CDKN2A
30camptothecin43 59 1210.9CDKN2A, MDM2, TP53
31docetaxel43 49 59 1211.9CDKN2A, MDM2, TP53
32mg 13243 599.9TP53, MDM2, CDKN2A
335-aza-2deoxycytidine438.9TP53, MDM2, CDKN2A
34arsenite43 249.9CDKN2A, MDM2, TP53
355fluorouracil438.9TP53, MDM2, CDKN2A
36agar438.9CDKN2A, MDM2, LGALS3
37paclitaxel43 49 1210.8CDKN2A, MDM2, TP53
38depsipeptide438.8CDKN2A, TP53
39doxorubicin43 49 1210.8TP53, MDM2, CDKN2A
40actinomycin d438.8CDKN2A, MDM2, TP53
41paraffin438.4TP53, LGALS3, MDM2, CDKN2A
42cisplatin43 49 59 1211.4TP53, LGALS3, MDM2, CDKN2A
43progesterone43 28 59 24 1212.4TP53, LGALS3, MDM2, CDKN2A
44h2o2438.4CDKN2A, MDM2, LGALS3, TP53
45oligonucleotide438.4TP53, LGALS3, MDM2, CDKN2A
46cycloheximide438.4CDKN2A, MDM2, TP53
47vegf438.4TP53, LGALS3, MDM2, CDKN2A
48arginine438.4CDKN2A, MDM2, LGALS3, TP53
49estrogen438.4CDKN2A, MDM2, LGALS3, TP53
50serine438.3CDKN2A, MDM2, LGALS3, TP53

GO Terms for genes affiliated with Adult Astrocytic Tumour

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Cellular components related to Adult Astrocytic Tumour according to GeneCards Suite gene sharing:

idNameGO IDScoreTop Affiliating Genes
1nuclear bodyGO:00166048.5CDKN2A, MDM2, TP53
2protein complexGO:00432348.4CDKN2A, MDM2, TP53
3nucleoplasmGO:00056548.2TP53, MDM2, CDKN2A
4cytoplasmGO:00057378.0CDKN2A, MDM2, LGALS3, TP53

Biological processes related to Adult Astrocytic Tumour according to GeneCards Suite gene sharing:

(show all 11)
idNameGO IDScoreTop Affiliating Genes
1response to antibioticGO:00466779.5TP53, MDM2
2DNA damage response, signal transduction by p53 class mediator resulting in cell cycle arrestGO:00069779.4TP53, MDM2
3replicative senescenceGO:00903999.4CDKN2A, TP53
4positive regulation of cell cycle arrestGO:00711589.4CDKN2A, TP53
5cellular response to hypoxiaGO:00714569.3MDM2, TP53
6protein destabilizationGO:00316489.2CDKN2A, MDM2
7protein complex assemblyGO:00064619.2TP53, MDM2
8Ras protein signal transductionGO:00072659.2CDKN2A, TP53
9cell cycle arrestGO:00070509.1CDKN2A, TP53
10negative regulation of cell growthGO:00303088.8CDKN2A, TP53
11negative regulation of transcription, DNA-templatedGO:00458928.7CDKN2A, MDM2, TP53

Molecular functions related to Adult Astrocytic Tumour according to GeneCards Suite gene sharing:

idNameGO IDScoreTop Affiliating Genes
1ubiquitin protein ligase bindingGO:00316259.3MDM2, TP53
2MDM2/MDM4 family protein bindingGO:00973718.8CDKN2A, TP53
3p53 bindingGO:00020398.4CDKN2A, MDM2, TP53

Products for genes affiliated with Adult Astrocytic Tumour

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Sources for Adult Astrocytic Tumour

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3CDC
13ExPASy
14FMA
22GTR
23HGMD
24HMDB
25ICD10
26ICD10 via Orphanet
27ICD9CM
28IUPHAR
29KEGG
33MeSH
34MESH via Orphanet
35MGI
38NCIt
39NDF-RT
42NINDS
43Novoseek
45OMIM
46OMIM via Orphanet
50PubMed
51QIAGEN
56SNOMED-CT via Orphanet
60UMLS
61UMLS via Orphanet