MCID: ADL053
MIFTS: 36

Adult Astrocytic Tumour malady

Cancer diseases category

Summaries for Adult Astrocytic Tumour

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MalaCards based summary: Adult Astrocytic Tumour, also known as adult astrocytoma, is related to astrocytoma and oligodendroglioma. An important gene associated with Adult Astrocytic Tumour is LGALS3 (lectin, galactoside-binding, soluble, 3), and among its related pathways are Spinal Cord Injury and Glucocorticoid receptor regulatory network. The compounds 10-hydroxycamptothecin and bpde have been mentioned in the context of this disorder. Related mouse phenotypes are renal/urinary system and pigmentation.

Aliases & Classifications for Adult Astrocytic Tumour

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Adult Astrocytic Tumour, Aliases & Descriptions:

Name: Adult Astrocytic Tumour 10
Adult Astrocytoma 10 62
 
Adult Astrocytic Tumors 62


Classifications:

Malacards categories (disease lists): (See all malacards categories)
Global: Cancer diseases


External Ids:

Disease Ontology10 DOID:3076
NCIt40 C7049

Related Diseases for Adult Astrocytic Tumour

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Diseases related to Adult Astrocytic Tumour via text searches within MalaCards or GeneCards/GeneDecks gene sharing:

(show top 50)    (show all 54)
idRelated DiseaseScoreTop Affiliating Genes
1astrocytoma30.4TP53, LGALS3, MDM2, CDKN2A
2oligodendroglioma29.9TP53, LGALS3, MDM2, CDKN2A
3glioblastoma29.9CDKN2A, MDM2, LGALS3, TP53
4actinic keratosis10.0TP53
5giant cell glioblastoma10.0MDM2
6thyroid cancer, anaplastic10.0LGALS3, TP53
7liposarcoma10.0MDM2, TP53
8cholangiocarcinoma10.0TP53, LGALS3
9basal cell carcinoma10.0LGALS3, TP53
10leiomyosarcoma10.0MDM2, TP53
11thyroid cancer10.0LGALS3, TP53
12li-fraumeni syndrome10.0CDKN2A, TP53
13oropharynx cancer10.0TP53, CDKN2A
14ataxia-telangiectasia10.0MDM2, TP53
15nasopharynx carcinoma10.0TP53, CDKN2A
16transitional cell carcinoma10.0TP53, MDM2
17barrett esophagus/esophageal adenocarcinoma10.0CDKN2A, TP53
18bladder cancer, somatic10.0CDKN2A, TP53
19rhabdomyosarcoma10.0MDM2, TP53
20laryngeal squamous cell carcinoma10.0TP53, CDKN2A
21esophageal cancer10.0CDKN2A, TP53
22papilloma10.0TP53, CDKN2A
23malignant peripheral nerve sheath tumor10.0CDKN2A, MDM2
24uveal melanoma10.0CDKN2A, MDM2
25squamous cell carcinoma, head and neck10.0CDKN2A, TP53
26multiple myeloma10.0TP53, CDKN2A
27acute lymphoblastic leukemia, childhood10.0CDKN2A, MDM2
28breast cancer10.0MDM2, LGALS3, TP53
29small cell cancer of the lung, somatic10.0CDKN2A, TP53
30lung cancer susceptibility 310.0CDKN2A, TP53
31pancreatic cancer10.0TP53, LGALS3, CDKN2A
32anaplastic oligodendroglioma10.0LGALS3, MDM2, CDKN2A
33oral cancer10.0CDKN2A, MDM2, TP53
34nasopharyngeal carcinoma10.0TP53, MDM2, CDKN2A
35adenoma10.0TP53, LGALS3, CDKN2A
36glioblastoma multiforme10.0CDKN2A, MDM2, TP53
37lung benign neoplasm10.0CDKN2A, MDM2, TP53
38b-cell lymphomas10.0CDKN2A, MDM2, TP53
39malignant glioma10.0CDKN2A, MDM2, TP53
40cervical cancer, somatic10.0TP53, MDM2, CDKN2A
41osteosarcoma, somatic10.0TP53, MDM2, CDKN2A
42prostate cancer10.0MDM2, LGALS3, TP53
43retinoblastoma10.0TP53, MDM2, CDKN2A
44ovarian cancer, somatic10.0CDKN2A, MDM2, TP53
45endometrial cancer10.0CDKN2A, TP53
46hepatocellular carcinoma10.0CDKN2A, MDM2, TP53
47lung cancer10.0CDKN2A, MDM2, TP53
48leukemia9.9TP53, MDM2, CDKN2A
49grade iii astrocytoma9.9CDKN2A, MDM2, LGALS3, TP53
50burkitt lymphoma9.9CDKN2A, MDM2, LGALS3, TP53

Graphical network of the top 20 diseases related to Adult Astrocytic Tumour:



Diseases related to adult astrocytic tumour

Symptoms for Adult Astrocytic Tumour

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Drugs & Therapeutics for Adult Astrocytic Tumour

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Drug clinical trials:

Search ClinicalTrials for Adult Astrocytic Tumour

Search NIH Clinical Center for Adult Astrocytic Tumour

Genetic Tests for Adult Astrocytic Tumour

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Anatomical Context for Adult Astrocytic Tumour

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Animal Models for Adult Astrocytic Tumour or affiliated genes

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Publications for Adult Astrocytic Tumour

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Articles related to Adult Astrocytic Tumour:

idTitleAuthorsYear
1
p53-independent mechanisms regulate the P2-MDM2 promoter in adult astrocytic tumours. (18781178)
2008
2
Galectin-3 and galectin-3-binding site expression in human adult astrocytic tumours and related angiogenesis. (10476049)
1999

Variations for Adult Astrocytic Tumour

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Expression for genes affiliated with Adult Astrocytic Tumour

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Search GEO for disease gene expression data for Adult Astrocytic Tumour.

Pathways for genes affiliated with Adult Astrocytic Tumour

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Pathways related to Adult Astrocytic Tumour according to GeneCards/GeneDecks:

(show all 47)
idSuper pathways (with members indented)ScoreTop Affiliating Genes
19.4LGALS3, TP53
29.3TP53, MDM2
3
Show member pathways
Immune response IL 4 signaling pathway60
Signal transduction AKT signaling60
9.3TP53, MDM2
4
Show member pathways
9.3TP53, MDM2
5
Show member pathways
9.3TP53, MDM2
69.3TP53, MDM2
7
Show member pathways
Prostate Cancer38
Integrated Cancer pathway38
Steroid Biosynthesis38
9.3TP53, MDM2
89.3MDM2, TP53
9
Show member pathways
ATM Signaling Pathway38
9.3MDM2, TP53
109.3MDM2, TP53
11
Show member pathways
p53 pathway38
9.3MDM2, TP53
129.3MDM2, TP53
139.3MDM2, TP53
14
Show member pathways
DNA damage Role of SUMO in p53 regulation60
9.3MDM2, TP53
15
Show member pathways
ErbB receptor signaling network38
ErbB signaling pathway38
9.3MDM2, TP53
16
Show member pathways
9.3MDM2, TP53
179.3MDM2, TP53
189.3MDM2, TP53
199.3MDM2, TP53
209.3MDM2, TP53
219.3MDM2, TP53
22
Show member pathways
Signal transduction PTEN pathway60
9.3MDM2, TP53
239.3MDM2, TP53
24
Show member pathways
9.1TP53, CDKN2A
25
Show member pathways
8.5TP53, MDM2, CDKN2A
26
Show member pathways
8.5TP53, MDM2, CDKN2A
27
Show member pathways
8.5TP53, MDM2, CDKN2A
28
Show member pathways
DNA damage response (only ATM dependent)38
Wnt Signaling Pathway and Pluripotency38
8.5TP53, MDM2, CDKN2A
29
Show member pathways
8.5TP53, MDM2, CDKN2A
30
Show member pathways
Apoptosis Modulation and Signaling38
Apoptosis38
8.5TP53, MDM2, CDKN2A
318.5TP53, MDM2, CDKN2A
328.5TP53, MDM2, CDKN2A
338.5TP53, MDM2, CDKN2A
348.5TP53, MDM2, CDKN2A
358.5CDKN2A, MDM2, TP53
368.5CDKN2A, MDM2, TP53
378.5CDKN2A, MDM2, TP53
388.5CDKN2A, MDM2, TP53
39
Show member pathways
DNA damage response38
8.5CDKN2A, MDM2, TP53
40
Show member pathways
8.5CDKN2A, MDM2, TP53
418.5CDKN2A, MDM2, TP53
42
Show member pathways
8.5CDKN2A, MDM2, TP53
43
Show member pathways
8.5CDKN2A, MDM2, TP53
44
Show member pathways
8.5CDKN2A, MDM2, TP53
45
Show member pathways
8.5CDKN2A, MDM2, TP53
46
Show member pathways
Signaling Pathways in Glioblastoma38
8.5CDKN2A, MDM2, TP53
47
Show member pathways
Cell cycle38
8.5CDKN2A, MDM2, TP53

Compounds for genes affiliated with Adult Astrocytic Tumour

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Compounds related to Adult Astrocytic Tumour according to GeneCards/GeneDecks:

(show top 50)    (show all 78)
idCompoundScoreTop Affiliating Genes
110-hydroxycamptothecin459.7MDM2, TP53
2bpde459.7TP53, MDM2
3chlorambucil45 1310.7MDM2, TP53
4acnu459.5CDKN2A, TP53
5hpvs459.5TP53, CDKN2A
6noxa459.5MDM2, TP53
7olomoucine45 1310.4CDKN2A, TP53
85-methylcytosine45 2610.4CDKN2A, TP53
9temozolomide45 1310.4TP53, CDKN2A
107,12-dimethylbenz(a)anthracene459.4MDM2, CDKN2A
11hmba459.4CDKN2A, TP53
12o6-methylguanine459.4CDKN2A, TP53
13bcnu459.3CDKN2A, TP53
142-chlorodeoxyadenosine459.3TP53, MDM2
15methylmethanesulfonate459.3MDM2, TP53
16dutp459.3MDM2, LGALS3, TP53
17leptomycin b45 6110.3TP53, LGALS3, MDM2
18crcs459.2TP53, CDKN2A
19etoposide45 51 61 1312.2MDM2, LGALS3, TP53
20p00001459.1CDKN2A, MDM2
21proline459.0TP53, LGALS3, MDM2
22aflatoxin b145 2610.0CDKN2A, MDM2, TP53
23butyrate459.0CDKN2A, LGALS3, TP53
24roscovitine459.0CDKN2A, MDM2, TP53
25flavopiridol45 139.9CDKN2A, MDM2, TP53
26irinotecan45 51 1310.9TP53, MDM2, CDKN2A
27thymidylate458.9CDKN2A, MDM2, TP53
28vincristine45 51 1310.9TP53, MDM2, CDKN2A
29adriamycin458.9TP53, MDM2, CDKN2A
30camptothecin45 61 1310.9CDKN2A, MDM2, TP53
31docetaxel45 51 61 1311.9CDKN2A, MDM2, TP53
32mg 13245 619.9TP53, MDM2, CDKN2A
335-aza-2deoxycytidine458.9TP53, MDM2, CDKN2A
34arsenite45 269.9CDKN2A, MDM2, TP53
355fluorouracil458.9TP53, MDM2, CDKN2A
36agar458.9CDKN2A, MDM2, LGALS3
37paclitaxel45 51 1310.8CDKN2A, MDM2, TP53
38depsipeptide458.8CDKN2A, TP53
39doxorubicin45 51 1310.8TP53, MDM2, CDKN2A
40actinomycin d458.8CDKN2A, MDM2, TP53
41paraffin458.4TP53, LGALS3, MDM2, CDKN2A
42cisplatin45 51 61 1311.4TP53, LGALS3, MDM2, CDKN2A
43progesterone45 30 61 26 1312.4TP53, LGALS3, MDM2, CDKN2A
44h2o2458.4CDKN2A, MDM2, LGALS3, TP53
45oligonucleotide458.4TP53, LGALS3, MDM2, CDKN2A
46cycloheximide458.4CDKN2A, MDM2, TP53
47vegf458.4TP53, LGALS3, MDM2, CDKN2A
48arginine458.4CDKN2A, MDM2, LGALS3, TP53
49estrogen458.4CDKN2A, MDM2, LGALS3, TP53
50serine458.3CDKN2A, MDM2, LGALS3, TP53

GO Terms for genes affiliated with Adult Astrocytic Tumour

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Cellular components related to Adult Astrocytic Tumour according to GeneCards/GeneDecks:

idNameGO IDScoreTop Affiliating Genes
1nuclear bodyGO:00166048.5CDKN2A, MDM2, TP53
2protein complexGO:00432348.4CDKN2A, MDM2, TP53
3nucleoplasmGO:00056548.2TP53, MDM2, CDKN2A
4cytoplasmGO:00057378.0CDKN2A, MDM2, LGALS3, TP53

Biological processes related to Adult Astrocytic Tumour according to GeneCards/GeneDecks:

(show all 11)
idNameGO IDScoreTop Affiliating Genes
1response to antibioticGO:00466779.5TP53, MDM2
2DNA damage response, signal transduction by p53 class mediator resulting in cell cycle arrestGO:00069779.4TP53, MDM2
3replicative senescenceGO:00903999.4CDKN2A, TP53
4positive regulation of cell cycle arrestGO:00711589.4CDKN2A, TP53
5cellular response to hypoxiaGO:00714569.3MDM2, TP53
6protein destabilizationGO:00316489.2CDKN2A, MDM2
7protein complex assemblyGO:00064619.2TP53, MDM2
8Ras protein signal transductionGO:00072659.2CDKN2A, TP53
9cell cycle arrestGO:00070509.1CDKN2A, TP53
10negative regulation of cell growthGO:00303088.8CDKN2A, TP53
11negative regulation of transcription, DNA-templatedGO:00458928.7CDKN2A, MDM2, TP53

Molecular functions related to Adult Astrocytic Tumour according to GeneCards/GeneDecks:

idNameGO IDScoreTop Affiliating Genes
1ubiquitin protein ligase bindingGO:00316259.3MDM2, TP53
2MDM2/MDM4 family protein bindingGO:00973718.8CDKN2A, TP53
3p53 bindingGO:00020398.4CDKN2A, MDM2, TP53

Products for genes affiliated with Adult Astrocytic Tumour

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Sources for Adult Astrocytic Tumour

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4CDC
15ExPASy
16FMA
24GTR
25HGMD
26HMDB
27ICD10
28ICD10 via Orphanet
29ICD9CM
30IUPHAR
31KEGG
35MeSH
36MESH via Orphanet
37MGI
40NCIt
41NDF-RT
44NINDS
45Novoseek
47OMIM
48OMIM via Orphanet
52PubMed
53QIAGEN
58SNOMED-CT via Orphanet
62UMLS
63UMLS via Orphanet