MCID: ADL027
MIFTS: 46

Adult Dermatomyositis malady

Muscle diseases, Skin diseases, Rare diseases, Neuronal diseases, Nephrological diseases, Bone diseases categories

Summaries for Adult Dermatomyositis

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34MalaCards
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MalaCards: Adult Dermatomyositis, also known as adult onset dermatomyositis, is related to dermatomyositis and calcinosis. An important gene associated with Adult Dermatomyositis is CHKB (choline kinase beta), and among its related pathways are Immune response Role of integrins in NK cells cytotoxicity and Development VEGF signaling and activation. The compounds thallium and alpha-hydroxybutyrate have been mentioned in the context of this disorder. Affiliated tissues include skin, and related mouse phenotypes are muscle and hematopoietic system.

Aliases & Classifications for Adult Dermatomyositis

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9Disease Ontology, 11DISEASES, 63UMLS
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Classifications:



Aliases & Descriptions:

adult dermatomyositis 9 11
adult onset dermatomyositis 9
adult type dermatomyositis 63


External Ids:

Disease Ontology9 DOID:14202

Related Diseases for Adult Dermatomyositis

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18GeneCards, 19GeneDecks
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Diseases in the Dermatomyositis family:

adult dermatomyositis

Diseases related to Adult Dermatomyositis via text searches within MalaCards or GeneCards/GeneDecks gene sharing:

(show top 50)    (show all 82)
idRelated DiseaseScoreTop Affiliating Genes
1dermatomyositis31.3PIK3C2A, VCAM1, CHKB, ICAM1
2calcinosis30.8PIK3C2A
3polymyositis30.3ICAM1, CHKB, VCAM1, PIK3C2A
4systemic lupus erythematosus30.2ICAM1, VCAM1, TNF
5inclusion body myositis30.1ICAM1, VCAM1
6myositis29.9ICAM1, CHKB, VCAM1, PIK3C2A
7pneumatosis cystoides intestinalis10.2
8lipodystrophy10.2
9lupus erythematosus10.2
10panniculitis10.1
11erysipelas10.1PIK3C2A
12status asthmaticus10.1PIK3C2A
13creatine phosphokinase, elevated serum10.1PIK3C2A, CHKB
14gas gangrene10.1PIK3C2A, CHKB
15ectopic pregnancy10.1PIK3C2A, CHKB
16pericardial effusion10.1CHKB, PIK3C2A
17neuroleptic malignant syndrome10.1CHKB, PIK3C2A
18middle ear cholesteatoma10.1CHKB, ICAM1
19leukostasis10.0VCAM1, ICAM1
20rheumatoid vasculitis10.0VCAM1, ICAM1
21acute kidney failure10.0CHKB, PIK3C2A
22arteriosclerosis obliterans10.0VCAM1, ICAM1
23immunoglobulin a vasculitis10.0ICAM1, VCAM1
24galactosemia10.0CHKB, PIK3C2A
25oral lichen planus10.0VCAM1, ICAM1
26vernal keratoconjunctivitis10.0ICAM1, VCAM1
27metabolic acidosis10.0PIK3C2A, CHKB
28duchenne muscular dystrophy10.0CHKB, PIK3C2A
29alcoholic hepatitis10.0ICAM1, TNF
30arteriosclerosis10.0VCAM1, ICAM1
31malaria10.0TNF, ICAM1
32pulmonary sarcoidosis10.0TNF, ICAM1
33proliferative diabetic retinopathy10.0ICAM1, VCAM1
34myotonic dystrophy10.0PIK3C2A, CHKB
35rhinitis10.0ICAM1, VCAM1
36periodontal disease10.0TNF, ICAM1
37autoimmune thyroiditis10.0ICAM1, CHKB
38lupus nephritis10.0ICAM1, VCAM1
39arthritis10.0TNF, ICAM1
40diabetic ketoacidosis10.0INS, PIK3C2A
41hypokalemia10.0INS, PIK3C2A
42monocytic leukemia10.0VCAM1, TNF
43hyperuricemia10.0PIK3C2A, INS
44pseudoxanthoma elasticum10.0
45childhood type dermatomyositis10.0
46arthropathy10.0
47esophagitis10.0
48pneumothorax10.0
49polyneuropathy10.0
50renal cell carcinoma10.0

Graphical network of the top 20 diseases related to Adult Dermatomyositis:



Diseases related to adult dermatomyositis

Symptoms for Adult Dermatomyositis

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Drugs & Therapeutics for Adult Dermatomyositis

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Sources:
6CenterWatch, 43NIH Clinical Center, 7ClinicalTrials
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Approved drugs:

Search CenterWatch for Adult Dermatomyositis

Drug clinical trials:

Search ClinicalTrials for Adult Dermatomyositis

Search NIH Clinical Center for Adult Dermatomyositis

Search CenterWatch for Adult Dermatomyositis

Genetic Tests for Adult Dermatomyositis

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Anatomical Context for Adult Dermatomyositis

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34MalaCards
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MalaCards organs/tissues related to Adult Dermatomyositis:

34
Skin

Animal Models for Adult Dermatomyositis or affiliated genes

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38MGI
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MGI Mouse Phenotypes related to Adult Dermatomyositis:

38
idDescriptionMGI Source AccessionScoreTop Affiliating Genes
1MP:00053698.8ICAM1, CHKB, TNF, INS
2MP:00053977.9PIK3C2A, INS, TNF, VCAM1, ICAM1
3MP:00053767.9PIK3C2A, INS, TNF, VCAM1, CHKB, ICAM1
4MP:00053787.4UBA2, ICAM1, VCAM1, TNF, INS, PIK3C2A
5MP:00107687.3PIK3C2A, INS, TNF, VCAM1, ICAM1, UBA2

Publications for Adult Dermatomyositis

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53PubMed
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Articles related to Adult Dermatomyositis:

(show top 50)    (show all 58)
idTitleAuthorsYear
1
Renal cell carcinoma-associated adult dermatomyositis treated laparoscopic nephrectomy. (24311917)
2013
2
Lacy reticular-pattern calcinosis in adult dermatomyositis. (23908532)
2013
3
Adult dermatomyositis associated with lipodystrophy. (23962582)
2013
4
A case of adult dermatomyositis associated with parainfluenza virus infection and Jo-1 antibody. (24341326)
2013
5
Analysis of metabolic syndrome in adult dermatomyositis with a focus on cardiovascular disease. (23139205)
2013
6
Focal lipodystrophy without metabolic disorders in adult dermatomyositis. (22804743)
2013
7
Marked improvement of calcinosis in adult dermatomyositis with etidronate therapy. (21710176)
2012
8
Adult dermatomyositis: experience of a Brazilian tertiary care center. (23223700)
2012
9
Changes in novel biomarkers of disease activity in juvenile and adult dermatomyositis are sensitive biomarkers of disease course. (22886447)
2012
10
Clinical features, pathogenesis and treatment of juvenile and adult dermatomyositis. (21947177)
2011
11
Adult dermatomyositis with severe polyneuropathy: does neuromyositis exist? (20229079)
2010
12
An extremely severe case of cutaneous calcinosis complicating adult dermatomyositis. (19076816)
2009
13
Clinical characteristics and outcomes of juvenile and adult dermatomyositis. (19654958)
2009
14
Case of pneumatosis cystoides intestinalis in adult dermatomyositis. (18181780)
2008
15
Lipodystrophy and metabolic abnormalities in a case of adult dermatomyositis. (17938031)
2007
16
Acute-onset adult dermatomyositis presenting with erythroderma and diplopia. (17868397)
2007
17
Difference in adhesion molecule expression (ICAM-1 and VCAM-1) in juvenile and adult dermatomyositis, polymyositis and inclusion body myositis. (16431335)
2006
18
Severe gastrointestinal inflammation in adult dermatomyositis: characterization of a novel clinical association. (17170621)
2006
19
Disease course, frequency of relapses and survival of 73 patients with juvenile or adult dermatomyositis. (15789887)
2005
20
Clinical significance of von Willebrand factor in patients with adult dermatomyositis. (15565394)
2005
21
Regression of cutis calcinosis with diltiazem in adult dermatomyositis. (15757822)
2005
22
Pruritus in adult dermatomyositis. (15115510)
2004
23
Uncertainties in the pathogenesis of adult dermatomyositis. (15167072)
2004
24
Digital infarcts showing microangiopathy in adult dermatomyositis suggest severe pulmonary involvement and poor prognosis. (15214917)
2004
25
Refractory adult dermatomyositis with pneumatosis cystoides intestinalis treated with infliximab. (15317960)
2004
26
A helpful clinical sign predictive of cancer in adult dermatomyositis: cutaneous necrosis. (12707108)
2003
27
Pseudoxanthoma elasticum (PXE)-like calcification in adult dermatomyositis. (12184640)
2002
28
Associations of tumor necrosis factor alpha and HLA polymorphisms with adult dermatomyositis: implications for a unique pathogenesis. (12230503)
2002
29
Routine vs extensive malignancy search for adult dermatomyositis and polymyositis: a study of 40 patients. (12071815)
2002
30
Familial adult dermatomyositis. (11251585)
2001
31
Aerobic capacity in adult dermatomyositis/polymyositis patients and healthy controls. (10638867)
2000
32
Dystrophic calcification in adult dermatomyositis: neuroimage. (11146618)
2000
33
A causal role for parvovirus B19 infection in adult dermatomyositis and other autoimmune syndromes. (11100810)
2000
34
Regression of calcinosis associated with adult dermatomyositis following diltiazem therapy. (10788545)
2000
35
Subcutaneous emphysema with spontaneous pneumomediastinum and pneumothorax in adult dermatomyositis. (10091485)
1999
36
Adult dermatomyositis with livedo reticularis and multiple skin ulcers. (9731966)
1998
37
A case of refractory adult dermatomyositis. (9651083)
1998
38
Epidermal necrosis as a predictive sign of malignancy in adult dermatomyositis. (9564590)
1998
39
Malignancy in adult dermatomyositis. (9466195)
1997
40
Spontaneous esophageal rupture in adult dermatomyositis. (8971517)
1996
41
Retinopathy in adult dermatomyositis. (8965274)
1995
42
Juvenile and adult dermatomyositis among the Chinese: a comparative study. (8299023)
1993
43
Cyclosporin A in adult dermatomyositis. (8495274)
1993
44
Severe acute form of adult dermatomyositis treated with cyclosporine. (1500250)
1992
45
Prognostic factors and predictive signs of malignancy in adult dermatomyositis. A study of 32 cases. (2334184)
1990
46
Early ultrastructural alterations in adult dermatomyositis. Capillary abnormalities precede other structural changes in muscle. (2614466)
1989
47
Prolonged spontaneous pneumomediastinum in adult dermatomyositis. (3662647)
1987
48
Jaccoud's arthropathy in adult dermatomyositis. (3533342)
1986
49
Spontaneous pneumomediastinum in adult dermatomyositis. (3767467)
1986
50
The prognosis of adult dermatomyositis. (5570265)
1971

Variations for Adult Dermatomyositis

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Expression for genes affiliated with Adult Dermatomyositis

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2BioGPS, 16Gene Expression Omnibus DataSets
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Expression patterns in normal tissues for genes affiliated with Adult Dermatomyositis

Search GEO for disease gene expression data for Adult Dermatomyositis.

Pathways for genes affiliated with Adult Dermatomyositis

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Sources:
51PathCards, 61Thomson Reuters, 56Reactome, 39NCBI BioSystems Database, 31KEGG, 54QIAGEN, 52PharmGKB
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Pathways related to Adult Dermatomyositis according to GeneCards/GeneDecks:

(show all 21)
idSuper pathways (with members indented)ScoreTop Affiliating Genes
19.7ICAM1, VCAM1
2
Show member pathways
Development VEGF signaling via VEGFR2 generic cascades61
9.7ICAM1, VCAM1
39.7ICAM1, VCAM1
49.7VCAM1, ICAM1
59.6VCAM1, TNF
69.5ICAM1, TNF
7
Show member pathways
9.3UBA2, SAE1
8
Show member pathways
DNA damage Role of SUMO in p53 regulation61
9.3UBA2, SAE1
99.2ICAM1, VCAM1, TNF
109.2ICAM1, VCAM1, TNF
119.2ICAM1, VCAM1, TNF
129.2ICAM1, VCAM1, TNF
139.2TNF, VCAM1, ICAM1
149.2ICAM1, VCAM1, TNF
159.2TNF, VCAM1, ICAM1
16
Show member pathways
9.1INS, TNF, ICAM1
17
Show member pathways
thioredoxin pathway39
9.1ICAM1, TNF, INS
18
Show member pathways
9.1VCAM1, ICAM1, IFIT3
19
Show member pathways
9.0PIK3C2A, INS, TNF
20
Show member pathways
8.8TNF, SAE1, UBA2
21
Show member pathways
8.5UBA2, ICAM1, SAE1, VCAM1

Compounds for genes affiliated with Adult Dermatomyositis

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Sources:
46Novoseek, 62Tocris Bioscience, 52PharmGKB, 12DrugBank, 30IUPHAR, 3BitterDB, 25HMDB
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Compounds related to Adult Dermatomyositis according to GeneCards/GeneDecks:

(show top 50)    (show all 120)
idCompoundScoreTop Affiliating Genes
1thallium469.9PIK3C2A, CHKB
2alpha-hydroxybutyrate469.9PIK3C2A, CHKB
3ro 31-7549469.9TNF, VCAM1
4tetramethylpyrazine469.9ICAM1, CHKB
5cdp571469.8ICAM1, TNF
6interferon gamma469.7ICAM1, TNF
7celastrol46 6210.7TNF, VCAM1
8sodium cromoglycate469.7ICAM1, VCAM1
9gliclazide46 52 1211.7VCAM1, INS, ICAM1
10cerivastatin52 46 30 1212.6PIK3C2A, CHKB, ICAM1
11apocynin46 6210.6VCAM1, TNF, ICAM1
12polymyxin b469.6TNF, ICAM1, VCAM1
13groalpha469.6ICAM1, TNF, VCAM1
14gemfibrozil30 46 1211.6PIK3C2A, INS, CHKB
15okt3469.6VCAM1, TNF, ICAM1
16budesonide46 52 1211.6VCAM1, TNF, ICAM1
17parthenolide46 310.6TNF, ICAM1, VCAM1
18bezafibrate46 30 1211.6CHKB, PIK3C2A, INS
19neopterin469.6TNF, ICAM1, CHKB
20diphenyleneiodonium469.5TNF, ICAM1, VCAM1
21pentoxifylline46 1210.5TNF, VCAM1, ICAM1
22alpha lipoic acid469.5VCAM1, TNF, INS
23pdtc469.5TNF, VCAM1, ICAM1
24melphalan46 52 1211.4PIK3C2A, TNF, CHKB
25pioglitazone30 46 52 1212.4INS, TNF, VCAM1
26uric acid46 2510.4PIK3C2A, CHKB, INS
27fluvastatin46 52 30 1212.3ICAM1, VCAM1, CHKB, PIK3C2A
28pravastatin46 52 30 25 1213.3CHKB, VCAM1, PIK3C2A, ICAM1
29mannitol46 1210.3VCAM1, CHKB, ICAM1
30endotoxin469.3TNF, VCAM1, ICAM1, CHKB
31sp 60012546 6210.2TNF, VCAM1, ICAM1
32n acetylcysteine469.2VCAM1, TNF, ICAM1, CHKB
33prednisolone46 30 1211.2PIK3C2A, TNF, VCAM1, CHKB
348-isoprostane469.2VCAM1, INS, TNF, ICAM1
35norepinephrine46 25 1211.1PIK3C2A, INS, VCAM1, CHKB
36troglitazone46 30 62 1212.1ICAM1, TNF, VCAM1, INS
37prostacyclin469.1PIK3C2A, ICAM1, TNF, VCAM1
38pge2469.1ICAM1, CHKB, VCAM1, TNF
39cyclosporin a46 30 6210.9CHKB, ICAM1, TNF, PIK3C2A
40rosiglitazone30 46 52 25 1212.8TNF, VCAM1, INS
41atorvastatin46 52 30 25 1212.8CHKB, VCAM1, ICAM1, TNF, PIK3C2A
42simvastatin46 52 62 30 25 1213.8VCAM1, TNF, PIK3C2A, CHKB, ICAM1
43dexamethasone46 52 30 1211.8ICAM1, VCAM1, TNF, INS, CHKB
44superoxide46 259.7TNF, PIK3C2A, VCAM1, CHKB
45vegf468.7ICAM1, CHKB, PIK3C2A, TNF, VCAM1
46fenofibrate46 52 1210.6PIK3C2A, INS, VCAM1, ICAM1, TNF
47ly294002468.6ICAM1, PIK3C2A, VCAM1, INS, TNF
48oxygen46 259.6PIK3C2A, ICAM1, VCAM1, CHKB, TNF
49fibrinogen468.3PIK3C2A, INS, TNF, VCAM1, CHKB, ICAM1
50lactate468.3ICAM1, CHKB, VCAM1, TNF, INS, PIK3C2A

GO Terms for genes affiliated with Adult Dermatomyositis

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17Gene Ontology
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Cellular components related to Adult Dermatomyositis according to GeneCards/GeneDecks:

idNameGO IDScoreTop Affiliating Genes
1external side of plasma membraneGO:0098978.9ICAM1, VCAM1, TNF
2extracellular spaceGO:0056158.7ICAM1, VCAM1, TNF, INS

Biological processes related to Adult Dermatomyositis according to GeneCards/GeneDecks:

(show all 17)
idNameGO IDScoreTop Affiliating Genes
1membrane to membrane dockingGO:02261410.0ICAM1, VCAM1
2leukocyte cell-cell adhesionGO:0071599.9ICAM1, VCAM1
3leukocyte tethering or rollingGO:0509019.9VCAM1, TNF
4heterophilic cell-cell adhesionGO:0071579.8ICAM1, VCAM1
5cellular response to glucose stimulusGO:0713339.8ICAM1, VCAM1
6negative regulation of lipid catabolic processGO:0509959.8INS, TNF
7positive regulation of cytokine secretionGO:0507159.7TNF, INS
8response to ionizing radiationGO:0102129.7ICAM1, VCAM1
9interferon-gamma-mediated signaling pathwayGO:0603339.7ICAM1, VCAM1
10positive regulation of mitosisGO:0458409.7TNF, INS
11protein sumoylationGO:0169259.5SAE1, UBA2
12positive regulation of nitric oxide biosynthetic processGO:0454299.4ICAM1, TNF, INS
13cellular response to tumor necrosis factorGO:0713569.4ICAM1, VCAM1
14positive regulation of NF-kappaB transcription factor activityGO:0510929.4INS, TNF, ICAM1
15cytokine-mediated signaling pathwayGO:0192219.3IFIT3, ICAM1, VCAM1
16extracellular matrix organizationGO:0301989.2TNF, VCAM1, ICAM1
17positive regulation of catalytic activityGO:0430859.2UBA2, SAE1

Molecular functions related to Adult Dermatomyositis according to GeneCards/GeneDecks:

idNameGO IDScoreTop Affiliating Genes
1protease bindingGO:0020209.5TNF, INS
2SUMO activating enzyme activityGO:0199489.2UBA2, SAE1
3enzyme activator activityGO:0080479.0UBA2, SAE1

Products for genes affiliated with Adult Dermatomyositis

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  • Antibodies
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Sources for Adult Dermatomyositis

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4CDC
14ExPASy
15FMA
23GTR
24HGMD
25HMDB
26ICD10
27ICD10 via Orphanet
28ICD9CM
30IUPHAR
31KEGG
36MeSH
37MESH via Orphanet
38MGI
41NCIt
42NDF-RT
45NINDS
46Novoseek
48OMIM
49OMIM via Orphanet
53PubMed
54QIAGEN
60SNOMED-CT via Orphanet
63UMLS
64UMLS via Orphanet