MCID: ADL027
MIFTS: 41

Adult Dermatomyositis malady

Summaries for Adult Dermatomyositis

About this section
Sources:
32MalaCards
See all sources

Fully expand this MalaCard

Export this MalaCard
MalaCards: Adult Dermatomyositis, also known as adult onset dermatomyositis, is related to dermatomyositis and inclusion body myositis. An important gene associated with Adult Dermatomyositis is CHKB (choline kinase beta), and among its related pathways are Cellular roles of Anthrax toxin and SUMOylation. The compounds pentoxifylline and norepinephrine have been mentioned in the context of this disorder. Affiliated tissues include lung, skin and skeletal muscle.

Aliases & Classifications for Adult Dermatomyositis

About this section
Sources:
8Disease Ontology, 10DISEASES, 60UMLS
See all sources

Aliases & Descriptions:

adult dermatomyositis 8 10
adult onset dermatomyositis 8
adult type dermatomyositis 60


External Ids:

Disease Ontology8 DOID:14202

Related Diseases for Adult Dermatomyositis

About this section
Sources:
17GeneCards, 18GeneDecks
See all sources

Diseases in the Dermatomyositis family:

adult dermatomyositis

Diseases related to Adult Dermatomyositis via text searches within MalaCards or GeneCards/GeneDecks gene sharing:

(show top 50)    (show all 121)
idRelated DiseaseScoreTop Affiliating Genes
1dermatomyositis31.2VCAM1, CHKB, PIK3C2A, ICAM1
2inclusion body myositis29.9ICAM1, VCAM1
3myositis29.9PIK3C2A, VCAM1, CHKB, ICAM1
4calcinosis10.4
5pneumatosis cystoides intestinalis10.2
6lipodystrophy10.2
7systemic lupus erythematosus10.1
8adult syndrome10.1
9lupus erythematosus10.1
10panniculitis10.1
11sleep disorder10.0CHKB
12deficiency anemia10.0CHKB
13myocarditis10.0CHKB
14sickle cell disease10.0VCAM1
15dementia10.0PIK3C2A
16blindness10.0INS
17antiphospholipid syndrome10.0VCAM1
18morbid obesity10.0INS
19hyperthyroidism10.0INS
20malignant hyperthermia10.0PIK3C2A
21peripheral vascular disease10.0INS
22thrombocytopenia10.0PIK3C2A
23uremia10.0VCAM1
24polycystic ovary syndrome10.0INS
25essential hypertension10.0INS
26glucose intolerance10.0INS
27cholera10.0INS
28erysipelas10.0PIK3C2A
29lichen planus10.0ICAM1
30status asthmaticus10.0PIK3C2A
31sjogren's syndrome10.0ICAM1
32metabolic syndrome x10.0INS
33alopecia areata10.0ICAM1
34insulinoma10.0INS
35peritonitis10.0TNF
36interstitial lung disease10.0TNF
37acute myocardial infarction10.0PIK3C2A, CHKB
38myocardial infarction10.0CHKB, PIK3C2A
39ankylosing spondylitis10.0TNF
40myotonic dystrophy10.0PIK3C2A, CHKB
41erythema multiforme10.0ICAM1
42creatine phosphokinase, elevated serum10.0PIK3C2A, CHKB
43gas gangrene10.0CHKB, PIK3C2A
44metabolic acidosis10.0PIK3C2A, CHKB
45dilated cardiomyopathy10.0PIK3C2A, CHKB
46fatty liver disease10.0INS
47ectopic pregnancy10.0CHKB, PIK3C2A
48psoriatic arthritis10.0TNF
49hypercholesterolemia10.0VCAM1, INS
50hyperglycemia10.0VCAM1, INS

Graphical network of the top 20 diseases related to Adult Dermatomyositis:



Diseases related to adult dermatomyositis

Clinical Features for Adult Dermatomyositis

About this section

Drugs & Therapeutics for Adult Dermatomyositis

About this section
Sources:
5CenterWatch, 41NIH Clinical Center, 6ClinicalTrials
See all sources

Approved drugs:

Search CenterWatch for Adult Dermatomyositis

Drug clinical trials:

Search ClinicalTrials for Adult Dermatomyositis

Search NIH Clinical Center for Adult Dermatomyositis

Search CenterWatch for Adult Dermatomyositis

Genetic Tests for Adult Dermatomyositis

About this section

Anatomical Context for Adult Dermatomyositis

About this section
Sources:
32MalaCards
See all sources

MalaCards organs/tissues related to Adult Dermatomyositis:

32
Lung, Skin, Skeletal muscle, Testes, Monocytes, T cells

Animal Models for Adult Dermatomyositis or affiliated genes

About this section

Publications for Adult Dermatomyositis

About this section
Sources:
50PubMed
See all sources

Articles related to Adult Dermatomyositis:

(show top 50)    (show all 95)
idTitleAuthorsYear
1
Calcinosis in adult-onset dermatomyositis: metastatic or dystrophic? (23943420)
2014
2
Rituximab in the treatment of refractory adult and juvenile dermatomyositis and adult polymyositis: a randomized, placebo-phase trial. (23124935)
2013
3
Lacy reticular-pattern calcinosis in adult dermatomyositis. (23908532)
2013
4
Calcinosis cutis in adult patient with dermatomyositis. (24209983)
2013
5
Adult and juvenile dermatomyositis: are the distinct clinical features explained by our current understanding of serological subgroups and pathogenic mechanisms? (23566358)
2013
6
Analysis of metabolic syndrome in adult dermatomyositis with a focus on cardiovascular disease. (23139205)
2013
7
Focal lipodystrophy without metabolic disorders in adult dermatomyositis. (22804743)
2013
8
MBL2 polymorphisms - manifestations in bulgarian patients with adult dermatomyositis and systemic lupus erythematosus. (24103065)
2013
9
Adult-onset Still's disease with dermatomyositis-like eruption. (22512689)
2012
10
Skeletal muscle major histocompatibility complex class I and II expression differences in adult and juvenile dermatomyositis. (22948454)
2012
11
Quality of life in adults with juvenile-onset dermatomyositis: a case-control study. (22328537)
2012
12
Marked improvement of calcinosis in adult dermatomyositis with etidronate therapy. (21710176)
2012
13
Intravenous immunoglobulin therapy in adult patients with polymyositis/dermatomyositis: a systematic literature review. (22274797)
2012
14
Changes in novel biomarkers of disease activity in juvenile and adult dermatomyositis are sensitive biomarkers of disease course. (22886447)
2012
15
Cardiac involvement in adult polymyositis or dermatomyositis: a systematic review. (22847365)
2012
16
Autoantibodies to nuclear matrix protein 2/MJ in adult-onset dermatomyositis with severe calcinosis. (22980285)
2012
17
Association of TNF-I+ polymorphisms with adult dermatomyositis and systemic lupus erythematosus in Bulgarian patients. (22913362)
2012
18
Subcutaneous fat calcinosis in adult-onset dermatomyositis. (22688480)
2011
19
Clinical status and cardiovascular risk profile of adults with a history of juvenile dermatomyositis. (21784434)
2011
20
Clinical correlations with dermatomyositis-specific autoantibodies in adult Japanese patients with dermatomyositis: a multicenter cross-sectional study. (21482889)
2011
21
Measures of adult and juvenile dermatomyositis, polymyositis, and inclusion body myositis: Physician and Patient/Parent Global Activity, Manual Muscle Testing (MMT), Health Assessment Questionnaire (HAQ)/Childhood Health Assessment Questionnaire (C-HAQ), Childhood Myositis Assessment Scale (CMAS), Myositis Disease Activity Assessment Tool (MDAAT), Disease Activity Score (DAS), Short Form 36 (SF-36), Child Health Questionnaire (CHQ), physician global damage, Myositis Damage Index (MDI), Quantitative Muscle Testing (QMT), Myositis Functional Index-2 (FI-2), Myositis Activities Profile (MAP), Inclusion Body Myositis Functional Rating Scale (IBMFRS), Cutaneous Dermatomyositis Disease Area and Severity Index (CDASI), Cutaneous Assessment Tool (CAT), Dermatomyositis Skin Severity Index (DSSI), Skindex, and Dermatology Life Quality Index (DLQI). (22588740)
2011
22
Adult dermatomyositis with severe polyneuropathy: does neuromyositis exist? (20229079)
2010
23
Clinical characteristics and outcomes of juvenile and adult dermatomyositis. (19654958)
2009
24
Calcinosis cutis: a rare feature of adult dermatomyositis. (18319027)
2008
25
Tracheoesophageal fistula: a rare complication of adult dermatomyositis. (18474474)
2008
26
Lipodystrophy and metabolic abnormalities in a case of adult dermatomyositis. (17938031)
2007
27
Acute-onset adult dermatomyositis presenting with erythroderma and diplopia. (17868397)
2007
28
Thrombotic microangiopathy in an adult patient with clinically amyopathic dermatomyositis complicated with interstitial lung disease. (18042598)
2007
29
A systematic review of adult-onset clinically amyopathic dermatomyositis (dermatomyositis sinAc myositis): a missing link within the spectrum of the idiopathic inflammatory myopathies. (16546580)
2006
30
Difference in adhesion molecule expression (ICAM-1 and VCAM-1) in juvenile and adult dermatomyositis, polymyositis and inclusion body myositis. (16431335)
2006
31
Severe gastrointestinal inflammation in adult dermatomyositis: characterization of a novel clinical association. (17170621)
2006
32
Disease course, frequency of relapses and survival of 73 patients with juvenile or adult dermatomyositis. (15789887)
2005
33
Pruritus in adult dermatomyositis. (15115510)
2004
34
Uncertainties in the pathogenesis of adult dermatomyositis. (15167072)
2004
35
A helpful clinical sign predictive of cancer in adult dermatomyositis: cutaneous necrosis. (12707108)
2003
36
Pseudoxanthoma elasticum (PXE)-like calcification in adult dermatomyositis. (12184640)
2002
37
Familial adult dermatomyositis. (11251585)
2001
38
Aerobic capacity in adult dermatomyositis/polymyositis patients and healthy controls. (10638867)
2000
39
Regression of calcinosis associated with adult dermatomyositis following diltiazem therapy. (10788545)
2000
40
A case of refractory adult dermatomyositis. (9651083)
1998
41
Elevated serum levels of neopterin in adult patients with polymyositis/dermatomyositis. (9236675)
1997
42
Spontaneous esophageal rupture in adult dermatomyositis. (8971517)
1996
43
Cyclosporin A in adult dermatomyositis. (8495274)
1993
44
First case of pneumatosis cystoides intestinalis in adult dermatomyositis. (8478857)
1993
45
A case of adult dermatomyositis treated with cyclosporin A. (1458294)
1992
46
Early ultrastructural alterations in adult dermatomyositis. Capillary abnormalities precede other structural changes in muscle. (2614466)
1989
47
Recurrent pneumomediastinum in adult dermatomyositis. (2724255)
1989
48
Jaccoud's arthropathy in adult dermatomyositis. (3533342)
1986
49
Spontaneous pneumomediastinum in adult dermatomyositis. (3767467)
1986
50
The prognosis of adult dermatomyositis. (5570265)
1971

Genetic Variations for Adult Dermatomyositis

About this section

Expression for genes affiliated with Adult Dermatomyositis

About this section
Sources:
1BioGPS, 15Gene Expression Omnibus DataSets
See all sources
Expression patterns in normal tissues for genes affiliated with Adult Dermatomyositis

Search GEO for disease gene expression data for Adult Dermatomyositis.

Pathways for genes affiliated with Adult Dermatomyositis

About this section
Sources:
37NCBI BioSystems Database, 53Reactome, 29KEGG, 12EMD Millipore, 51QIAGEN, 49PharmGKB
See all sources

Compounds for genes affiliated with Adult Dermatomyositis

About this section
Sources:
44Novoseek, 11DrugBank, 24HMDB, 28IUPHAR, 59Tocris Bioscience, 49PharmGKB, 2BitterDB
See all sources

Compounds related to Adult Dermatomyositis according to GeneCards/GeneDecks:

(show top 50)    (show all 89)
idCompoundScoreTop Affiliating Genes
1pentoxifylline44 1111.5VCAM1
2norepinephrine44 11 2412.5CHKB
3okt34410.1ICAM1, VCAM1
4mannitol44 1111.1ICAM1
5prednisolone44 28 1112.1PIK3C2A, CHKB
6thallium4410.0CHKB, PIK3C2A
7ro 31-75494410.0TNF, VCAM1
8alpha-hydroxybutyrate4410.0CHKB, PIK3C2A
9tetramethylpyrazine4410.0CHKB, ICAM1
10cdp571449.9TNF, ICAM1
11uric acid44 2410.9CHKB, PIK3C2A
12interferon gamma449.9TNF, ICAM1
13celastrol44 5910.8TNF, VCAM1
14sodium cromoglycate449.8VCAM1, ICAM1
15apocynin44 5910.7ICAM1, VCAM1, TNF
16polymyxin b449.7ICAM1, VCAM1, TNF
17groalpha449.6TNF, VCAM1, ICAM1
18budesonide44 49 1111.6TNF, VCAM1, ICAM1
19parthenolide44 210.6ICAM1, TNF, VCAM1
20cerivastatin44 49 28 1112.6PIK3C2A, ICAM1, CHKB
21diphenyleneiodonium449.6TNF, VCAM1, ICAM1
22neopterin449.6CHKB, ICAM1, TNF
23gliclazide44 49 1111.6ICAM1, INS, VCAM1
24melphalan44 1110.5CHKB, TNF, PIK3C2A
25gemfibrozil44 28 1111.5PIK3C2A, INS, CHKB
26pdtc449.5TNF, VCAM1, ICAM1
27alpha lipoic acid449.5VCAM1, INS, TNF
28bezafibrate44 28 1111.5PIK3C2A, CHKB, INS
29pioglitazone44 49 28 1112.4VCAM1, INS, TNF
30sp 60012544 5910.3TNF, ICAM1, VCAM1
31endotoxin449.3CHKB, TNF, VCAM1, ICAM1
32n-tosyl-l-phenylalanine chloromethyl ketone449.3TNF, ICAM1
33fluvastatin44 49 28 1112.3VCAM1, PIK3C2A, ICAM1, CHKB
34pravastatin44 49 28 11 2413.3PIK3C2A, VCAM1, ICAM1, CHKB
35n acetylcysteine449.3TNF, CHKB, VCAM1, ICAM1
36oxygen44 2410.3PIK3C2A, TNF, ICAM1
37superoxide44 2410.2CHKB, VCAM1, TNF
388-isoprostane449.2VCAM1, INS, ICAM1, TNF
39troglitazone44 28 59 1112.1ICAM1, TNF, VCAM1, INS
40rosiglitazone44 49 28 11 2413.1TNF, INS, VCAM1
41prostacyclin449.1ICAM1, TNF, PIK3C2A, VCAM1
42cyclosporin a44 28 5910.9CHKB, PIK3C2A, TNF, ICAM1
43atorvastatin44 49 28 11 2412.8VCAM1, TNF, CHKB, PIK3C2A, ICAM1
44simvastatin44 49 59 28 11 2413.8CHKB, TNF, PIK3C2A, ICAM1, VCAM1
45dexamethasone44 49 28 1111.7INS, TNF, VCAM1, CHKB, ICAM1
46vegf448.7PIK3C2A, VCAM1, ICAM1, CHKB, TNF
47fenofibrate44 49 1110.6INS, PIK3C2A, TNF, ICAM1, VCAM1
48ly294002448.6ICAM1, TNF, INS, VCAM1, PIK3C2A
49fibrinogen448.3PIK3C2A, CHKB, TNF, VCAM1, ICAM1, INS
50lactate448.3PIK3C2A, TNF, INS, VCAM1, ICAM1, CHKB

GO Terms for genes affiliated with Adult Dermatomyositis

About this section
Sources:
16Gene Ontology
See all sources

Cellular components related to Adult Dermatomyositis according to GeneCards/GeneDecks:

idNameGO IDScoreTop Affiliating Genes
1external side of plasma membraneGO:0098979.2VCAM1, TNF, ICAM1

Biological processes related to Adult Dermatomyositis according to GeneCards/GeneDecks:

(show all 12)
idNameGO IDScoreTop Affiliating Genes
1membrane to membrane dockingGO:0226149.9VCAM1, ICAM1
2leukocyte tethering or rollingGO:0509019.8VCAM1, TNF
3leukocyte cell-cell adhesionGO:0071599.8ICAM1, VCAM1
4cellular response to glucose stimulusGO:0713339.7VCAM1, ICAM1
5negative regulation of lipid catabolic processGO:0509959.7INS, TNF
6positive regulation of cytokine secretionGO:0507159.6TNF, INS
7positive regulation of mitosisGO:0458409.5TNF, INS
8heterophilic cell-cell adhesionGO:0071579.4VCAM1, ICAM1
9positive regulation of nitric oxide biosynthetic processGO:0454299.3INS, TNF, ICAM1
10positive regulation of NF-kappaB transcription factor activityGO:0510929.3ICAM1, TNF, INS
11protein sumoylationGO:0169259.2UBA2, SAE1
12cytokine-mediated signaling pathwayGO:0192219.1VCAM1, ICAM1, IFIT3

Molecular functions related to Adult Dermatomyositis according to GeneCards/GeneDecks:

idNameGO IDScoreTop Affiliating Genes
1SUMO activating enzyme activityGO:0199489.3SAE1, UBA2

Products for genes affiliated with Adult Dermatomyositis

About this section
  • Antibodies
  • Proteins
  • Lysates
  • Antibodies

Sources for Adult Dermatomyositis

About this section
3CDC
13ExPASy
14FMA
22GTR
23HGMD
24HMDB
25ICD10
26ICD10 via Orphanet
27ICD9CM
28IUPHAR
29KEGG
34MeSH
35MESH via Orphanet
36MGI
39NCIt
40NDF-RT
43NINDS
44Novoseek
46OMIM
47OMIM via Orphanet
50PubMed
51QIAGEN
57SNOMED-CT via Orphanet
60UMLS
61UMLS via Orphanet