MCID: ADL027
MIFTS: 46

Adult Dermatomyositis malady

Muscle diseases, Skin diseases, Rare diseases, Neuronal diseases, Nephrological diseases, Bone diseases categories
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Summaries for Adult Dermatomyositis

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MalaCards based summary: Adult Dermatomyositis, also known as adult onset dermatomyositis, is related to calcinosis and dermatomyositis. An important gene associated with Adult Dermatomyositis is CHKB (choline kinase beta), and among its related pathways are Immune response Role of integrins in NK cells cytotoxicity and Development VEGF signaling and activation. The compounds thallium and alpha-hydroxybutyrate have been mentioned in the context of this disorder. Affiliated tissues include skin, and related mouse phenotypes are muscle and hematopoietic system.

Aliases & Classifications for Adult Dermatomyositis

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Adult Dermatomyositis, Aliases & Descriptions:

Name: Adult Dermatomyositis 8 10
Adult Onset Dermatomyositis 8 62
 
Adult Type Dermatomyositis 62


Classifications:



External Ids:

Disease Ontology8 DOID:14202

Related Diseases for Adult Dermatomyositis

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Diseases in the Dermatomyositis family:

adult dermatomyositis

Diseases related to Adult Dermatomyositis via text searches within MalaCards or GeneCards/GeneDecks gene sharing:

(show top 50)    (show all 82)
idRelated DiseaseScoreTop Affiliating Genes
1calcinosis31.3PIK3C2A
2dermatomyositis31.1ICAM1, CHKB, VCAM1, PIK3C2A
3inclusion body myositis30.3VCAM1, ICAM1
4systemic lupus erythematosus30.3ICAM1, VCAM1, TNF
5polymyositis30.2PIK3C2A, CHKB, ICAM1, VCAM1
6myositis29.8ICAM1, VCAM1, CHKB, PIK3C2A
7erysipelas10.4PIK3C2A
8status asthmaticus10.4PIK3C2A
9creatine phosphokinase, elevated serum10.3PIK3C2A, CHKB
10gas gangrene10.3CHKB, PIK3C2A
11ectopic pregnancy10.3PIK3C2A, CHKB
12pericardial effusion10.3CHKB, PIK3C2A
13neuroleptic malignant syndrome10.3CHKB, PIK3C2A
14pneumatosis cystoides intestinalis10.3
15lipodystrophy10.3
16lupus erythematosus10.3
17middle ear cholesteatoma10.2ICAM1, CHKB
18leukostasis10.2ICAM1, VCAM1
19rheumatoid vasculitis10.2VCAM1, ICAM1
20acute kidney failure10.2PIK3C2A, CHKB
21arteriosclerosis obliterans10.2ICAM1, VCAM1
22immunoglobulin a vasculitis10.2ICAM1, VCAM1
23galactosemia10.2CHKB, PIK3C2A
24oral lichen planus10.2VCAM1, ICAM1
25vernal keratoconjunctivitis10.2VCAM1, ICAM1
26metabolic acidosis10.2PIK3C2A, CHKB
27duchenne muscular dystrophy10.2PIK3C2A, CHKB
28panniculitis10.1
29alcoholic hepatitis10.1ICAM1, TNF
30arteriosclerosis10.1VCAM1, ICAM1
31malaria10.1TNF, ICAM1
32pulmonary sarcoidosis10.1ICAM1, TNF
33proliferative diabetic retinopathy10.1VCAM1, ICAM1
34myotonic dystrophy10.1CHKB, PIK3C2A
35rhinitis10.1VCAM1, ICAM1
36periodontal disease10.1TNF, ICAM1
37autoimmune thyroiditis10.1CHKB, ICAM1
38lupus nephritis10.1ICAM1, VCAM1
39arthritis10.1ICAM1, TNF
40diabetic ketoacidosis10.1PIK3C2A, INS
41hypokalemia10.0INS, PIK3C2A
42monocytic leukemia10.0VCAM1, TNF
43hyperuricemia10.0PIK3C2A, INS
44childhood type dermatomyositis10.0
45renal cell carcinoma10.0
46pseudoxanthoma elasticum10.0
47arthropathy10.0
48esophagitis10.0
49pneumothorax10.0
50polyneuropathy10.0

Graphical network of the top 20 diseases related to Adult Dermatomyositis:



Diseases related to adult dermatomyositis

Symptoms for Adult Dermatomyositis

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Drugs & Therapeutics for Adult Dermatomyositis

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Drug clinical trials:

Search ClinicalTrials for Adult Dermatomyositis

Search NIH Clinical Center for Adult Dermatomyositis

Genetic Tests for Adult Dermatomyositis

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Anatomical Context for Adult Dermatomyositis

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MalaCards organs/tissues related to Adult Dermatomyositis:

32
Skin

Animal Models for Adult Dermatomyositis or affiliated genes

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MGI Mouse Phenotypes related to Adult Dermatomyositis:

36
idDescriptionMGI Source AccessionScoreTop Affiliating Genes
1MP:00053698.8ICAM1, CHKB, TNF, INS
2MP:00053977.9PIK3C2A, INS, TNF, VCAM1, ICAM1
3MP:00053767.9PIK3C2A, INS, TNF, VCAM1, CHKB, ICAM1
4MP:00053787.4UBA2, ICAM1, VCAM1, TNF, INS, PIK3C2A
5MP:00107687.3PIK3C2A, INS, TNF, VCAM1, ICAM1, UBA2

Publications for Adult Dermatomyositis

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Articles related to Adult Dermatomyositis:

(show top 50)    (show all 61)
idTitleAuthorsYear
1
IL-1RN VNTR Polymorphism in Adult Dermatomyositis and Systemic Lupus Erythematosus. (25328514)
2014
2
A case of adult dermatomyositis with calcinosis universalis. (25400376)
2014
3
HLA class II alleles may influence susceptibility to adult dermatomyositis and polymyositis in a Han Chinese population. (24894810)
2014
4
Adult dermatomyositis with bleeding ulcer in the pharynx. (25328739)
2014
5
Renal cell carcinoma-associated adult dermatomyositis treated laparoscopic nephrectomy. (24311917)
2013
6
Lacy reticular-pattern calcinosis in adult dermatomyositis. (23908532)
2013
7
Adult dermatomyositis associated with lipodystrophy. (23962582)
2013
8
A case of adult dermatomyositis associated with parainfluenza virus infection and Jo-1 antibody. (24341326)
2013
9
Analysis of metabolic syndrome in adult dermatomyositis with a focus on cardiovascular disease. (23139205)
2013
10
Focal lipodystrophy without metabolic disorders in adult dermatomyositis. (22804743)
2013
11
Marked improvement of calcinosis in adult dermatomyositis with etidronate therapy. (21710176)
2012
12
Adult dermatomyositis: experience of a Brazilian tertiary care center. (23223700)
2012
13
Clinical features, pathogenesis and treatment of juvenile and adult dermatomyositis. (21947177)
2011
14
Adult dermatomyositis with severe polyneuropathy: does neuromyositis exist? (20229079)
2010
15
An extremely severe case of cutaneous calcinosis complicating adult dermatomyositis. (19076816)
2009
16
Clinical characteristics and outcomes of juvenile and adult dermatomyositis. (19654958)
2009
17
Case of pneumatosis cystoides intestinalis in adult dermatomyositis. (18181780)
2008
18
Lipodystrophy and metabolic abnormalities in a case of adult dermatomyositis. (17938031)
2007
19
Acute-onset adult dermatomyositis presenting with erythroderma and diplopia. (17868397)
2007
20
Difference in adhesion molecule expression (ICAM-1 and VCAM-1) in juvenile and adult dermatomyositis, polymyositis and inclusion body myositis. (16431335)
2006
21
Disease course, frequency of relapses and survival of 73 patients with juvenile or adult dermatomyositis. (15789887)
2005
22
Clinical significance of von Willebrand factor in patients with adult dermatomyositis. (15565394)
2005
23
Regression of cutis calcinosis with diltiazem in adult dermatomyositis. (15757822)
2005
24
Pruritus in adult dermatomyositis. (15115510)
2004
25
Uncertainties in the pathogenesis of adult dermatomyositis. (15167072)
2004
26
Digital infarcts showing microangiopathy in adult dermatomyositis suggest severe pulmonary involvement and poor prognosis. (15214917)
2004
27
A helpful clinical sign predictive of cancer in adult dermatomyositis: cutaneous necrosis. (12707108)
2003
28
Pseudoxanthoma elasticum (PXE)-like calcification in adult dermatomyositis. (12184640)
2002
29
Associations of tumor necrosis factor alpha and HLA polymorphisms with adult dermatomyositis: implications for a unique pathogenesis. (12230503)
2002
30
Familial adult dermatomyositis. (11251585)
2001
31
Aerobic capacity in adult dermatomyositis/polymyositis patients and healthy controls. (10638867)
2000
32
Dystrophic calcification in adult dermatomyositis: neuroimage. (11146618)
2000
33
A causal role for parvovirus B19 infection in adult dermatomyositis and other autoimmune syndromes. (11100810)
2000
34
Regression of calcinosis associated with adult dermatomyositis following diltiazem therapy. (10788545)
2000
35
Subcutaneous emphysema with spontaneous pneumomediastinum and pneumothorax in adult dermatomyositis. (10091485)
1999
36
Adult dermatomyositis with livedo reticularis and multiple skin ulcers. (9731966)
1998
37
A case of refractory adult dermatomyositis. (9651083)
1998
38
Epidermal necrosis as a predictive sign of malignancy in adult dermatomyositis. (9564590)
1998
39
Spontaneous esophageal rupture in adult dermatomyositis. (8971517)
1996
40
Retinopathy in adult dermatomyositis. (8965274)
1995
41
Juvenile and adult dermatomyositis among the Chinese: a comparative study. (8299023)
1993
42
Cyclosporin A in adult dermatomyositis. (8495274)
1993
43
A case of adult dermatomyositis treated with cyclosporin A. (1458294)
1992
44
Severe acute form of adult dermatomyositis treated with cyclosporine. (1500250)
1992
45
Prognostic factors and predictive signs of malignancy in adult dermatomyositis. A study of 32 cases. (2334184)
1990
46
Early ultrastructural alterations in adult dermatomyositis. Capillary abnormalities precede other structural changes in muscle. (2614466)
1989
47
Prolonged spontaneous pneumomediastinum in adult dermatomyositis. (3662647)
1987
48
Jaccoud's arthropathy in adult dermatomyositis. (3533342)
1986
49
Spontaneous pneumomediastinum in adult dermatomyositis. (3767467)
1986
50
The prognosis of adult dermatomyositis. (5570265)
1971

Variations for Adult Dermatomyositis

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Expression for genes affiliated with Adult Dermatomyositis

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Expression patterns in normal tissues for genes affiliated with Adult Dermatomyositis

Search GEO for disease gene expression data for Adult Dermatomyositis.

Pathways for genes affiliated with Adult Dermatomyositis

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Pathways related to Adult Dermatomyositis according to GeneCards/GeneDecks:

(show all 21)
idSuper pathways (with members indented)ScoreTop Affiliating Genes
19.7ICAM1, VCAM1
2
Show member pathways
Development VEGF signaling via VEGFR2 generic cascades60
9.7ICAM1, VCAM1
39.7ICAM1, VCAM1
49.7VCAM1, ICAM1
59.6VCAM1, TNF
69.5ICAM1, TNF
7
Show member pathways
9.3UBA2, SAE1
8
Show member pathways
DNA damage Role of SUMO in p53 regulation60
9.3UBA2, SAE1
99.2ICAM1, VCAM1, TNF
109.2ICAM1, VCAM1, TNF
119.2ICAM1, VCAM1, TNF
129.2ICAM1, VCAM1, TNF
139.2TNF, VCAM1, ICAM1
149.2ICAM1, VCAM1, TNF
159.2TNF, VCAM1, ICAM1
16
Show member pathways
9.1INS, TNF, ICAM1
17
Show member pathways
thioredoxin pathway37
9.1ICAM1, TNF, INS
18
Show member pathways
9.1VCAM1, ICAM1, IFIT3
19
Show member pathways
9.0PIK3C2A, INS, TNF
20
Show member pathways
8.8TNF, SAE1, UBA2
21
Show member pathways
8.5UBA2, ICAM1, SAE1, VCAM1

Compounds for genes affiliated with Adult Dermatomyositis

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Compounds related to Adult Dermatomyositis according to GeneCards/GeneDecks:

(show top 50)    (show all 120)
idCompoundScoreTop Affiliating Genes
1thallium449.9PIK3C2A, CHKB
2alpha-hydroxybutyrate449.9PIK3C2A, CHKB
3ro 31-7549449.9TNF, VCAM1
4tetramethylpyrazine449.9ICAM1, CHKB
5cdp571449.8ICAM1, TNF
6interferon gamma449.7ICAM1, TNF
7celastrol44 6110.7TNF, VCAM1
8sodium cromoglycate449.7ICAM1, VCAM1
9gliclazide44 50 1111.7VCAM1, INS, ICAM1
10cerivastatin50 44 28 1112.6PIK3C2A, CHKB, ICAM1
11apocynin44 6110.6VCAM1, TNF, ICAM1
12polymyxin b449.6TNF, ICAM1, VCAM1
13groalpha449.6ICAM1, TNF, VCAM1
14gemfibrozil28 44 1111.6PIK3C2A, INS, CHKB
15okt3449.6VCAM1, TNF, ICAM1
16budesonide44 50 1111.6VCAM1, TNF, ICAM1
17parthenolide44 210.6TNF, ICAM1, VCAM1
18bezafibrate44 28 1111.6CHKB, PIK3C2A, INS
19neopterin449.6TNF, ICAM1, CHKB
20diphenyleneiodonium449.5TNF, ICAM1, VCAM1
21pentoxifylline44 1110.5TNF, VCAM1, ICAM1
22alpha lipoic acid449.5VCAM1, TNF, INS
23pdtc449.5TNF, VCAM1, ICAM1
24melphalan44 50 1111.4PIK3C2A, TNF, CHKB
25pioglitazone28 44 50 1112.4INS, TNF, VCAM1
26uric acid44 2410.4PIK3C2A, CHKB, INS
27fluvastatin44 50 28 1112.3ICAM1, VCAM1, CHKB, PIK3C2A
28pravastatin44 50 28 24 1113.3CHKB, VCAM1, PIK3C2A, ICAM1
29mannitol44 1110.3VCAM1, CHKB, ICAM1
30endotoxin449.3TNF, VCAM1, ICAM1, CHKB
31sp 60012544 6110.2TNF, VCAM1, ICAM1
32n acetylcysteine449.2VCAM1, TNF, ICAM1, CHKB
33prednisolone44 28 1111.2PIK3C2A, TNF, VCAM1, CHKB
348-isoprostane449.2VCAM1, INS, TNF, ICAM1
35norepinephrine44 24 1111.1PIK3C2A, INS, VCAM1, CHKB
36troglitazone44 28 61 1112.1ICAM1, TNF, VCAM1, INS
37prostacyclin449.1PIK3C2A, ICAM1, TNF, VCAM1
38pge2449.1ICAM1, CHKB, VCAM1, TNF
39cyclosporin a44 28 6110.9CHKB, ICAM1, TNF, PIK3C2A
40rosiglitazone28 44 50 24 1112.8TNF, VCAM1, INS
41atorvastatin44 50 28 24 1112.8CHKB, VCAM1, ICAM1, TNF, PIK3C2A
42simvastatin44 50 61 28 24 1113.8VCAM1, TNF, PIK3C2A, CHKB, ICAM1
43dexamethasone44 50 28 1111.8ICAM1, VCAM1, TNF, INS, CHKB
44superoxide44 249.7TNF, PIK3C2A, VCAM1, CHKB
45vegf448.7ICAM1, CHKB, PIK3C2A, TNF, VCAM1
46fenofibrate44 50 1110.6PIK3C2A, INS, VCAM1, ICAM1, TNF
47ly294002448.6ICAM1, PIK3C2A, VCAM1, INS, TNF
48oxygen44 249.6PIK3C2A, ICAM1, VCAM1, CHKB, TNF
49fibrinogen448.3PIK3C2A, INS, TNF, VCAM1, CHKB, ICAM1
50lactate448.3ICAM1, CHKB, VCAM1, TNF, INS, PIK3C2A

GO Terms for genes affiliated with Adult Dermatomyositis

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Cellular components related to Adult Dermatomyositis according to GeneCards/GeneDecks:

idNameGO IDScoreTop Affiliating Genes
1external side of plasma membraneGO:0098978.9ICAM1, VCAM1, TNF
2extracellular spaceGO:0056158.7ICAM1, VCAM1, TNF, INS

Biological processes related to Adult Dermatomyositis according to GeneCards/GeneDecks:

(show all 17)
idNameGO IDScoreTop Affiliating Genes
1membrane to membrane dockingGO:02261410.0ICAM1, VCAM1
2leukocyte cell-cell adhesionGO:0071599.9ICAM1, VCAM1
3leukocyte tethering or rollingGO:0509019.9VCAM1, TNF
4heterophilic cell-cell adhesionGO:0071579.8ICAM1, VCAM1
5cellular response to glucose stimulusGO:0713339.8ICAM1, VCAM1
6negative regulation of lipid catabolic processGO:0509959.8INS, TNF
7positive regulation of cytokine secretionGO:0507159.7TNF, INS
8response to ionizing radiationGO:0102129.7ICAM1, VCAM1
9interferon-gamma-mediated signaling pathwayGO:0603339.7ICAM1, VCAM1
10positive regulation of mitosisGO:0458409.7TNF, INS
11protein sumoylationGO:0169259.5SAE1, UBA2
12positive regulation of nitric oxide biosynthetic processGO:0454299.4ICAM1, TNF, INS
13cellular response to tumor necrosis factorGO:0713569.4ICAM1, VCAM1
14positive regulation of NF-kappaB transcription factor activityGO:0510929.4INS, TNF, ICAM1
15cytokine-mediated signaling pathwayGO:0192219.3IFIT3, ICAM1, VCAM1
16extracellular matrix organizationGO:0301989.2TNF, VCAM1, ICAM1
17positive regulation of catalytic activityGO:0430859.2UBA2, SAE1

Molecular functions related to Adult Dermatomyositis according to GeneCards/GeneDecks:

idNameGO IDScoreTop Affiliating Genes
1protease bindingGO:0020209.5TNF, INS
2SUMO activating enzyme activityGO:0199489.2UBA2, SAE1
3enzyme activator activityGO:0080479.0UBA2, SAE1

Products for genes affiliated with Adult Dermatomyositis

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Sources for Adult Dermatomyositis

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3CDC
13ExPASy
14FMA
22GTR
23HGMD
24HMDB
25ICD10
26ICD10 via Orphanet
27ICD9CM
28IUPHAR
29KEGG
34MeSH
35MESH via Orphanet
36MGI
39NCIt
40NDF-RT
43NINDS
44Novoseek
46OMIM
47OMIM via Orphanet
51PubMed
52QIAGEN
58SNOMED-CT via Orphanet
62UMLS
63UMLS via Orphanet