MCID: ADL027
MIFTS: 31

Adult Dermatomyositis malady

Categories: Muscle diseases, Skin diseases, Rare diseases, Neuronal diseases, Nephrological diseases, Bone diseases

Aliases & Classifications for Adult Dermatomyositis

Aliases & Descriptions for Adult Dermatomyositis:

Name: Adult Dermatomyositis 12 14
Adult Onset Dermatomyositis 12
Adult Type Dermatomyositis 69

Classifications:



External Ids:

Disease Ontology 12 DOID:14202

Summaries for Adult Dermatomyositis

MalaCards based summary : Adult Dermatomyositis, also known as adult onset dermatomyositis, is related to childhood type dermatomyositis and dermatomyositis. An important gene associated with Adult Dermatomyositis is MBL2 (Mannose Binding Lectin 2). The drugs Abatacept and Pirfenidone have been mentioned in the context of this disorder. Affiliated tissues include skin and colon.

Related Diseases for Adult Dermatomyositis

Diseases in the Dermatomyositis family:

Adult Dermatomyositis

Diseases related to Adult Dermatomyositis via text searches within MalaCards or GeneCards Suite gene sharing:

(show all 46)
id Related Disease Score Top Affiliating Genes
1 childhood type dermatomyositis 31.5 MBL2 TNF
2 dermatomyositis 11.5
3 warthin tumor 10.2 MBL2 TNF
4 phlyctenulosis 10.2 MBL2 TNF
5 functional gastric disease 10.2 MBL2 TNF
6 infiltrating ureter transitional cell carcinoma 10.2 CHKB TNF
7 endogenous depression 10.2 MBL2 TNF
8 migraine with aura 10.2 CHKB TNF
9 peripheral artery disease 10.2 MBL2 TNF
10 vogt-koyanagi-harada disease 10.2 GPT TNF
11 hereditary alpha tryptasemia syndrome 10.1 GPT TNF
12 fasciitis 10.1 MBL2 TNF
13 bladder sarcoma 10.1 GPT TNF
14 benign deep fibrous histiocytoma 10.1 GPT TNF
15 hemolytic-uremic syndrome 10.1 GPT TNF
16 paranasal sinus sarcoma 10.1 GPT TNF
17 congenital hypoplastic anemia 10.1 GPT TNF
18 amelogenesis imperfecta 10.1 GPT TNF
19 nephropathy with pretibial epidermolysis bullosa and deafness 10.1 MBL2 TNF
20 fiedler's myocarditis 10.1 GPT TNF
21 bacterial meningitis 10.1 GPT TNF
22 pulmonary eosinophilia 10.1 MBL2 TNF
23 noninfectious dermatoses of eyelid 10.0 GPT TNF
24 brown's tendon sheath syndrome 10.0 CHKB TNF
25 hyperuricemia, pulmonary hypertension, renal failure, and alkalosis 10.0 MBL2 TNF
26 hereditary spastic paraplegia 10.0 GPT MBL2 TNF
27 calcinosis 10.0
28 chronic angina 9.9 DMBX1 SAE1
29 periarthritis 9.9 MBL2 TNF
30 lupus erythematosus 9.8
31 systemic lupus erythematosus 9.8
32 polymyositis 9.8
33 pneumatosis cystoides intestinalis 9.7
34 lipodystrophy 9.7
35 pseudoxanthoma elasticum 9.5
36 hypoxia 9.5
37 inclusion body myositis 9.5
38 esophagitis 9.5
39 polyneuropathy 9.5
40 pneumothorax 9.5
41 teratoma 9.5
42 arthropathy 9.5
43 myositis 9.5
44 renal cell carcinoma 9.5
45 tracheoesophageal fistula 9.5
46 tracheal calcification 9.1 CHKB DMBX1 GPT MBL2 MLH3 SAE1

Graphical network of the top 20 diseases related to Adult Dermatomyositis:



Diseases related to Adult Dermatomyositis

Symptoms & Phenotypes for Adult Dermatomyositis

Drugs & Therapeutics for Adult Dermatomyositis

Drugs for Adult Dermatomyositis (from DrugBank, HMDB, Dgidb, PharmGKB, IUPHAR, NovoSeek, BitterDB):

(show top 50) (show all 111)
id Name Status Phase Clinical Trials Cas Number PubChem Id
1
Abatacept Approved Phase 4,Phase 3,Phase 2 332348-12-6 10237
2
Pirfenidone Investigational Phase 4 53179-13-8 40632
3 Vaccines Phase 4
4 Hormone Antagonists Phase 4,Phase 3,Phase 2,Phase 1
5 Hormones Phase 4,Phase 3,Phase 2,Phase 1
6 Hormones, Hormone Substitutes, and Hormone Antagonists Phase 4,Phase 3,Phase 2,Phase 1
7 Antirheumatic Agents Phase 4,Phase 3,Phase 2,Phase 1
8 Immunosuppressive Agents Phase 4,Phase 3,Phase 2,Phase 1
9 Anti-Inflammatory Agents Phase 4,Phase 3,Phase 2,Phase 1
10 Peripheral Nervous System Agents Phase 4,Phase 3,Phase 2,Phase 1
11 Adrenocorticotropic Hormone Phase 4,Phase 2
12 beta-endorphin Phase 4,Phase 2
13 Melanocyte-Stimulating Hormones Phase 4,Phase 2
14 Analgesics Phase 4,Phase 2,Phase 3,Phase 1
15 Analgesics, Non-Narcotic Phase 4,Phase 2,Phase 3,Phase 1
16 Anti-Inflammatory Agents, Non-Steroidal Phase 4,Phase 2,Phase 3,Phase 1
17
Cyclosporine Approved, Investigational, Vet_approved Phase 3 79217-60-0, 59865-13-3 5284373 6435893
18
Levoleucovorin Approved Phase 3,Phase 2 68538-85-2
19
Methotrexate Approved Phase 3,Phase 2 1959-05-2, 59-05-2 126941
20
Methylprednisolone Approved, Vet_approved Phase 3,Phase 2 83-43-2 6741
21
Miconazole Approved, Investigational, Vet_approved Phase 3 22916-47-8 4189
22
Prednisolone Approved, Vet_approved Phase 3,Phase 2 50-24-8 5755
23
Prednisone Approved, Vet_approved Phase 3,Phase 2 53-03-2 5865
24
Benzocaine Approved Phase 2, Phase 3 1994-09-7, 94-09-7 2337
25
Tacrolimus Approved, Investigational Phase 2, Phase 3 104987-11-3 445643 439492
26
Alendronate Approved Phase 2, Phase 3 121268-17-5, 66376-36-1 2088
27
Infliximab Approved Phase 2, Phase 3 170277-31-3
28
Cyclophosphamide Approved, Investigational Phase 2, Phase 3,Phase 1 50-18-0, 6055-19-2 2907
29
rituximab Approved Phase 2, Phase 3 174722-31-7 10201696
30
Etanercept Approved, Investigational Phase 2, Phase 3,Phase 1 185243-69-0
31
belimumab Approved Phase 2, Phase 3 356547-88-1 5957 10451420
32
Acetylcysteine Approved, Investigational Phase 2, Phase 3 616-91-1 12035
33
Folic Acid Approved, Nutraceutical, Vet_approved Phase 3,Phase 2 59-30-3 6037
34
leucovorin Approved, Nutraceutical Phase 3,Phase 2 58-05-9 54575, 6560146 143
35 tannic acid Approved, Nutraceutical Phase 2, Phase 3
36 Antiemetics Phase 3,Phase 2
37 Antifungal Agents Phase 3
38 Anti-Infective Agents Phase 3,Phase 2,Phase 1
39 Antimetabolites Phase 3,Phase 2
40 Antimetabolites, Antineoplastic Phase 3,Phase 2
41 Antineoplastic Agents, Hormonal Phase 3,Phase 2
42 Autonomic Agents Phase 3,Phase 2
43 Calcineurin Inhibitors Phase 3,Phase 2
44 Dermatologic Agents Phase 3,Phase 2
45 Folic Acid Antagonists Phase 3,Phase 2
46 Gastrointestinal Agents Phase 3,Phase 2,Phase 1
47 glucocorticoids Phase 3,Phase 2,Phase 1
48 Methylprednisolone acetate Phase 3,Phase 2
49 Methylprednisolone Hemisuccinate Phase 3,Phase 2
50 Neuroprotective Agents Phase 3,Phase 2

Interventional clinical trials:

(show top 50) (show all 76)
id Name Status NCT ID Phase
1 Immune Response After Human Papillomavirus Vaccination in Patients With Autoimmune Disease Unknown status NCT00815282 Phase 4
2 Safety and Efficacy of Anti-Pandemic H1N1 Vaccination in Rheumatic Diseases Unknown status NCT01151644 Phase 4
3 Efficacy and Safety of H.P. Acthar Gel for the Treatment of Refractory Cutaneous Manifestations of Dermatomyositis Recruiting NCT02245841 Phase 4
4 Abatacept in Juvenile Dermatomyositis Recruiting NCT02594735 Phase 4
5 Pirfenidone in Progressive Interstitial Lung Disease Associated With Clinically Amyopathic Dermatomyositis Not yet recruiting NCT02821689 Phase 4
6 Five-year Actively Controlled Clinical Trial in New Onset Juvenile Dermatomyositis Unknown status NCT00323960 Phase 3
7 Investigation in Myositis-associated Pneumonitis of Prednisolone And Concomitant Tacrolimus Unknown status NCT00504348 Phase 2, Phase 3
8 Efficacy and Safety Study of GB-0998 for Treatment of Steroid-resistant Polymyositis and Dermatomyositis (PM/DM) Completed NCT00335985 Phase 3
9 Combined Treatment of Methotrexate + Glucocorticoids Versus Glucocorticoids Alone in Patients With PM and DM Completed NCT00651040 Phase 3
10 Alendronate Osteoporosis Study Completed NCT00277251 Phase 2, Phase 3
11 Anakinra in Myositis Completed NCT01165008 Phase 2, Phase 3
12 Treatment With TNF Blockade, Infliximab, in Patients With Myositis Completed NCT00443222 Phase 2, Phase 3
13 Study Evaluating Efficacy and Safety of Octagam 10% in Patients With Dermatomyositis (Idiopathic Inflammatory Myopathy) Recruiting NCT02728752 Phase 3
14 Rituximab Versus Cyclophosphamide in Connective Tissue Disease-ILD Recruiting NCT01862926 Phase 2, Phase 3
15 Trial to Evaluate the Efficacy and Safety of Abatacept in Combination With Standard Therapy Compared to Standard Therapy Alone in Improving Disease Activity in Adults With Active Idiopathic Inflammatory Myopathy Recruiting NCT02971683 Phase 3
16 Belimumab in Myositis Recruiting NCT02347891 Phase 2, Phase 3
17 Understanding the Pathogenesis and Treatment of Childhood Onset Dermatomyositis Terminated NCT00035958 Phase 2, Phase 3
18 A Clinical Trial for CTD-ILD Treatment Terminated NCT01424033 Phase 2, Phase 3
19 Abatacept Treatment in Polymyositis and Dermatomyositis Unknown status NCT01315938 Phase 2
20 Topical Sodium Thiosulfate and Fractional Carbon Dioxide Laser in Treating Dermatomyositis Associated Calcinosis Completed NCT01572844 Phase 2
21 Acthar in Treatment of Refractory Dermatomyositis and Polymyositis Completed NCT01906372 Phase 2
22 Safety and Effectiveness of h5G1.1-mAb for Dermatomyositis Completed NCT00005571 Phase 2
23 Safety and Efficacy of BAF312 in Dermatomyositis Completed NCT02029274 Phase 2
24 Methimazole to Treat Polymyositis and Dermatomyositis Completed NCT00001421 Phase 2
25 Infliximab (Remicade ) to Treat Dermatomyositis and Polymyositis Completed NCT00033891 Phase 2
26 Efficacy of an Individual Rehabilitation Program in Polymyositis and Dermatomyositis Completed NCT01415219 Phase 2
27 Absorption of Corticosteroids in Children With Juvenile Dermatomyositis Completed NCT00004357 Phase 2
28 Rituximab for the Treatment of Refractory Adult and Juvenile Dermatomyositis (DM) and Adult Polymyositis (PM) Completed NCT00106184 Phase 2
29 Intravenousimmunoglobulin (IVIg) for the Treatment of Inflammatory Myopathies Completed NCT00001261 Phase 2
30 A Study to Evaluate the Long-Term Safety of MEDI-545 in Adult Participants With Systemic Lupus Erythematosus or Myositis Completed NCT00979654 Phase 2
31 Trial of IMO-8400 in Adult Patients With Dermatomyositis Recruiting NCT02612857 Phase 2
32 Safety, Tolerability, and Efficacy of JBT-101 in Subjects With Dermatomyositis Recruiting NCT02466243 Phase 2
33 Study of IFN-K in Dermatomyositis Recruiting NCT02980198 Phase 2
34 Tocilizumab in the Treatment of Refractory Polymyositis and Dermatomyositis Recruiting NCT02043548 Phase 2
35 A Study In Adults With Moderate To Severe Dermatomyositis Not yet recruiting NCT03181893 Phase 2
36 Denosumab for Glucocorticoid-treated Children With Rheumatic Disorders Not yet recruiting NCT02418273 Phase 1, Phase 2
37 Efficacy and Tolerability of BAF312 in Patients With Polymyositis and Dermatomyositis Terminated NCT01148810 Phase 2
38 A Pilot Study to Evaluate Topical Sodium Thiosulfate Therapy for Calcinosis Cutis Withdrawn NCT01918904 Phase 2
39 Evaluation of the Safety and Effectiveness of Tailored Transoral Incisionless Fundoplication (TIF) Using EsophyX for the Treatment of GERD Withdrawn NCT01025739 Phase 2
40 A Pilot Study of Etanercept in Dermatomyositis Completed NCT00112385 Phase 1
41 A Study to Evaluate Safety of Multi-Dose MEDI-545 in Adult Patients With Dermatomyositis or Polymyositis Completed NCT00533091 Phase 1
42 Pilot Study of Total Body Irradiation in Combination With Cyclophosphamide, Anti-thymocyte Globulin, and Autologous CD34-Selected Peripheral Blood Stem Cell Transplantation in Children With Refractory Autoimmune Disorders Completed NCT00010335 Phase 1
43 Mycophenolate Mofetil in Systemic Sclerosis Completed NCT00433186 Phase 1
44 Study of Tofacitinib in Refractory Dermatomyositis Recruiting NCT03002649 Phase 1
45 A Phase 1 Study of MEDI7734 in Type I Interferon-Mediated Autoimmune Diseases Recruiting NCT02780674 Phase 1
46 Creatine Supplementation in Pediatric Rheumatology Unknown status NCT01217320
47 A Case-control Study to Assess Risk of Coronary Heart Disease in Idiopathic Inflammatory Myopathy Unknown status NCT00971828
48 Study of the Prevalence of Polymyositis and Dermatomyositis in Normandy Completed NCT02880527
49 Outcome in Patients With Recent Onset Polymyositis and Dermatomyositis Completed NCT01813617
50 Hand Function in Patients With Poly- or Dermatomyositis Completed NCT00866125

Search NIH Clinical Center for Adult Dermatomyositis

Genetic Tests for Adult Dermatomyositis

Anatomical Context for Adult Dermatomyositis

MalaCards organs/tissues related to Adult Dermatomyositis:

39
Skin, Colon

Publications for Adult Dermatomyositis

Articles related to Adult Dermatomyositis:

(show top 50) (show all 74)
id Title Authors Year
1
Gene Expression Profiling in Blood and Affected Muscle Tissues Reveals Differential Activation Pathways in Patients with New-onset Juvenile and Adult Dermatomyositis. ( 27803134 )
2017
2
Environmental factors associated with disease flare in juvenile and adult dermatomyositis. ( 28444299 )
2017
3
Association of vitamin D receptor gene BsmI B/b and FokI F/f polymorphisms with adult dermatomyositis and systemic lupus erythematosus. ( 26972080 )
2016
4
Anti-TIF1-I^-positive young adult dermatomyositis with germ cell tumour. ( 27457276 )
2016
5
Differential roles of hypoxia and innate immunity in juvenile and adult dermatomyositis. ( 27121733 )
2016
6
Colonic vasculopathy and perforation in the initial presentation of adult dermatomyositis in a patient with improving muscle weakness. ( 26759443 )
2016
7
Universalis Calcinosis in Adult Dermatomyositis: An "Anti-NXP2 Syndrome". ( 27660942 )
2016
8
Adult dermatomyositis associated with benign ovarian teratoma: A case report. ( 27073526 )
2016
9
Gastrointestinal endarteropathy in adult dermatomyositis. ( 26184526 )
2015
10
Severe adult dermatomyositis with unusual calcinosis. ( 26286744 )
2015
11
Clinico pathological study of adult dermatomyositis: Importance of muscle histology in the diagnosis. ( 26019418 )
2015
12
Adult dermatomyositis with bleeding ulcer in the pharynx. ( 25328739 )
2014
13
IL-1RN VNTR Polymorphism in Adult Dermatomyositis and Systemic Lupus Erythematosus. ( 25328514 )
2014
14
HLA class II alleles may influence susceptibility to adult dermatomyositis and polymyositis in a Han Chinese population. ( 24894810 )
2014
15
A case of adult dermatomyositis with calcinosis universalis. ( 25400376 )
2014
16
Focal lipodystrophy without metabolic disorders in adult dermatomyositis. ( 22804743 )
2013
17
MBL2 polymorphisms - manifestations in bulgarian patients with adult dermatomyositis and systemic lupus erythematosus. ( 24103065 )
2013
18
Adult dermatomyositis associated with lipodystrophy. ( 23962582 )
2013
19
Analysis of metabolic syndrome in adult dermatomyositis with a focus on cardiovascular disease. ( 23139205 )
2013
20
A case of adult dermatomyositis associated with parainfluenza virus infection and Jo-1 antibody. ( 24341326 )
2013
21
Renal cell carcinoma-associated adult dermatomyositis treated laparoscopic nephrectomy. ( 24311917 )
2013
22
Therapy of calcinosis universalis complicating adult dermatomyositis. ( 24131911 )
2013
23
Lacy reticular-pattern calcinosis in adult dermatomyositis. ( 23908532 )
2013
24
Adult dermatomyositis: experience of a Brazilian tertiary care center. ( 23223700 )
2012
25
Association of TNF-I+ polymorphisms with adult dermatomyositis and systemic lupus erythematosus in Bulgarian patients. ( 22913362 )
2012
26
Marked improvement of calcinosis in adult dermatomyositis with etidronate therapy. ( 21710176 )
2012
27
Changes in novel biomarkers of disease activity in juvenile and adult dermatomyositis are sensitive biomarkers of disease course. ( 22886447 )
2012
28
Clinical features, pathogenesis and treatment of juvenile and adult dermatomyositis. ( 21947177 )
2011
29
Adult dermatomyositis with severe polyneuropathy: does neuromyositis exist? ( 20229079 )
2010
30
An extremely severe case of cutaneous calcinosis complicating adult dermatomyositis. ( 19076816 )
2009
31
Clinical characteristics and outcomes of juvenile and adult dermatomyositis. ( 19654958 )
2009
32
Tracheoesophageal fistula: a rare complication of adult dermatomyositis. ( 18474474 )
2008
33
Case of pneumatosis cystoides intestinalis in adult dermatomyositis. ( 18181780 )
2008
34
Calcinosis cutis: a rare feature of adult dermatomyositis. ( 18319027 )
2008
35
Lipodystrophy and metabolic abnormalities in a case of adult dermatomyositis. ( 17938031 )
2007
36
Acute-onset adult dermatomyositis presenting with erythroderma and diplopia. ( 17868397 )
2007
37
Severe gastrointestinal inflammation in adult dermatomyositis: characterization of a novel clinical association. ( 17170621 )
2006
38
Difference in adhesion molecule expression (ICAM-1 and VCAM-1) in juvenile and adult dermatomyositis, polymyositis and inclusion body myositis. ( 16431335 )
2006
39
Disease course, frequency of relapses and survival of 73 patients with juvenile or adult dermatomyositis. ( 15789887 )
2005
40
Regression of cutis calcinosis with diltiazem in adult dermatomyositis. ( 15757822 )
2005
41
Clinical significance of von Willebrand factor in patients with adult dermatomyositis. ( 15565394 )
2005
42
Pruritus in adult dermatomyositis. ( 15115510 )
2004
43
Refractory adult dermatomyositis with pneumatosis cystoides intestinalis treated with infliximab. ( 15317960 )
2004
44
Uncertainties in the pathogenesis of adult dermatomyositis. ( 15167072 )
2004
45
Digital infarcts showing microangiopathy in adult dermatomyositis suggest severe pulmonary involvement and poor prognosis. ( 15214917 )
2004
46
A helpful clinical sign predictive of cancer in adult dermatomyositis: cutaneous necrosis. ( 12707108 )
2003
47
Pseudoxanthoma elasticum (PXE)-like calcification in adult dermatomyositis. ( 12184640 )
2002
48
Associations of tumor necrosis factor alpha and HLA polymorphisms with adult dermatomyositis: implications for a unique pathogenesis. ( 12230503 )
2002
49
Routine vs extensive malignancy search for adult dermatomyositis and polymyositis: a study of 40 patients. ( 12071815 )
2002
50
Familial adult dermatomyositis. ( 11251585 )
2001

Variations for Adult Dermatomyositis

Expression for Adult Dermatomyositis

Search GEO for disease gene expression data for Adult Dermatomyositis.

Pathways for Adult Dermatomyositis

GO Terms for Adult Dermatomyositis

Biological processes related to Adult Dermatomyositis according to GeneCards Suite gene sharing:

id Name GO ID Score Top Affiliating Genes
1 defense response to Gram-positive bacterium GO:0050830 9.16 MBL2 TNF
2 positive regulation of phagocytosis GO:0050766 8.96 MBL2 TNF
3 negative regulation of growth of symbiont in host GO:0044130 8.62 MBL2 TNF

Sources for Adult Dermatomyositis

3 CDC
7 CNVD
9 Cosmic
10 dbSNP
11 DGIdb
16 ExPASy
18 FMA
28 GO
29 GTR
30 HGMD
31 HMDB
32 HPO
33 ICD10
34 ICD10 via Orphanet
35 ICD9CM
36 IUPHAR
37 KEGG
38 LifeMap
40 MedGen
42 MeSH
43 MESH via Orphanet
44 MGI
46 NCI
47 NCIt
48 NDF-RT
51 NINDS
52 Novoseek
54 OMIM
55 OMIM via Orphanet
59 PubMed
60 QIAGEN
65 SNOMED-CT via Orphanet
67 TGDB
68 Tocris
69 UMLS
70 UMLS via Orphanet
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