MCID: ADL027
MIFTS: 37

Adult Dermatomyositis malady

Summaries for Adult Dermatomyositis

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33MalaCards
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MalaCards: Adult Dermatomyositis, also known as adult onset dermatomyositis, is related to polymyositis and inclusion body myositis. An important gene associated with Adult Dermatomyositis is CHKB (choline kinase beta), and among its related pathways are Cellular roles of Anthrax toxin and SUMOylation. The compounds pentoxifylline and norepinephrine have been mentioned in the context of this disorder. Affiliated tissues include skin, lung and skeletal muscle.

Aliases & Classifications for Adult Dermatomyositis

Sources:
8Disease Ontology, 10DISEASES, 61UMLS
See all sources

Aliases & Descriptions:

adult dermatomyositis 8 10
adult onset dermatomyositis 8
adult type dermatomyositis 61


External Ids:

Disease Ontology8 DOID:14202

Related Diseases for Adult Dermatomyositis

Sources:
17GeneCards, 18GeneDecks
See all sources

Diseases in the dermatomyositis family:

adult dermatomyositis

Diseases related to Adult Dermatomyositis via text searches within MalaCards or GeneCards/GeneDecks gene sharing:

(show top 50)    (show all 115)
idRelated DiseaseScoreTop Affiliating Genes
1polymyositis30.3PIK3C2A, VCAM1, CHKB, ICAM1
2inclusion body myositis30.0ICAM1, VCAM1
3pneumatosis cystoides intestinalis10.2
4systemic lupus erythematosus10.1
5adult syndrome10.1
6pseudoxanthoma elasticum10.0
7childhood type dermatomyositis10.0
8arthropathy10.0
9tracheoesophageal fistula10.0
10spontaneous pneumothorax10.0
11sleep disorder10.0CHKB
12deficiency anemia10.0CHKB
13myocarditis10.0CHKB
14sickle cell disease10.0VCAM1
15dementia10.0PIK3C2A
16blindness10.0INS
17antiphospholipid syndrome10.0VCAM1
18morbid obesity10.0INS
19hyperthyroidism10.0INS
20malignant hyperthermia10.0PIK3C2A
21peripheral vascular disease10.0INS
22thrombocytopenia10.0PIK3C2A
23uremia10.0VCAM1
24polycystic ovary syndrome10.0INS
25essential hypertension10.0INS
26glucose intolerance10.0INS
27cholera10.0INS
28erysipelas10.0PIK3C2A
29lichen planus10.0ICAM1
30status asthmaticus10.0PIK3C2A
31sjogren's syndrome10.0ICAM1
32metabolic syndrome x10.0INS
33alopecia areata10.0ICAM1
34insulinoma10.0INS
35peritonitis10.0TNF
36interstitial lung disease10.0TNF
37acute myocardial infarction10.0PIK3C2A, CHKB
38myocardial infarction10.0CHKB, PIK3C2A
39ankylosing spondylitis10.0TNF
40myotonic dystrophy10.0PIK3C2A, CHKB
41erythema multiforme10.0ICAM1
42creatine phosphokinase, elevated serum10.0PIK3C2A, CHKB
43gas gangrene10.0CHKB, PIK3C2A
44metabolic acidosis10.0PIK3C2A, CHKB
45dilated cardiomyopathy10.0PIK3C2A, CHKB
46fatty liver disease10.0INS
47ectopic pregnancy10.0CHKB, PIK3C2A
48psoriatic arthritis10.0TNF
49hypercholesterolemia10.0VCAM1, INS
50hyperglycemia10.0VCAM1, INS

Graphical network of the top 20 diseases related to Adult Dermatomyositis:



Diseases related to adult dermatomyositis

Clinical Features for Adult Dermatomyositis

Drugs & Therapeutics for Adult Dermatomyositis

Sources:
5CenterWatch, 42NIH Clinical Center, 6ClinicalTrials
See all sources

Approved drugs:

Search CenterWatch for Adult Dermatomyositis

Drug clinical trials:

Search ClinicalTrials for Adult Dermatomyositis

Search NIH Clinical Center for Adult Dermatomyositis

Search CenterWatch for Adult Dermatomyositis

Genetic Tests for Adult Dermatomyositis

Anatomical Context for Adult Dermatomyositis

Sources:
33MalaCards
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MalaCards organs/tissues related to Adult Dermatomyositis:

33
Skin, Lung, Skeletal muscle, Monocytes, T cells

Animal Models for Adult Dermatomyositis or affiliated genes

Sources:
28inGenious Targeting Laboratory
See all sources

Publications for Adult Dermatomyositis

Sources:
51PubMed
See all sources

Articles related to Adult Dermatomyositis:

(show top 50)    (show all 97)
idTitleAuthorsYear
1
Calcinosis in adult-onset dermatomyositis: metastatic or dystrophic? (23943420)
2014
2
Renal cell carcinoma-associated adult dermatomyositis treated laparoscopic nephrectomy. (24311917)
2013
3
Adult dermatomyositis associated with lipodystrophy. (23962582)
2013
4
Childhood dermatomyositis recurring in adulthood half a century later. (24000211)
2013
5
A case of adult dermatomyositis associated with parainfluenza virus infection and Jo-1 antibody. (24341326)
2013
6
Analysis of metabolic syndrome in adult dermatomyositis with a focus on cardiovascular disease. (23139205)
2013
7
Predictors of clinical improvement in rituximab-treated refractory adult and juvenile dermatomyositis and adult polymyositis. (24249095)
2013
8
Suppression of soluble T cell-associated proteins by an anti-interferon-I+ monoclonal antibody in adult patients with dermatomyositis or polymyositis. (24357810)
2013
9
Anti-TIF1I^ antibodies (anti-p155) in adult patients with dermatomyositis: comparison of different diagnostic assays. (22294626)
2012
10
Skeletal muscle major histocompatibility complex class I and II expression differences in adult and juvenile dermatomyositis. (22948454)
2012
11
Anti-MJ/NXP-2 autoantibody specificity in a cohort of adult Italian patients with polymyositis/dermatomyositis. (22546500)
2012
12
Adult dermatomyositis: experience of a Brazilian tertiary care center. (23223700)
2012
13
Two young-adult female cases of dermatomyositis with antibodies for transcriptional intermediary factor 1-I^. (22992252)
2012
14
Cardiac involvement in adult polymyositis or dermatomyositis: a systematic review. (22847365)
2012
15
Morbidity and mortality in adult polymyositis and dermatomyositis. (22410829)
2012
16
Dermatomyositis associated with HIV-1 infection in a Nigerian adult female: a case report. (23066424)
2012
17
Association of TNF-I+ polymorphisms with adult dermatomyositis and systemic lupus erythematosus in Bulgarian patients. (22913362)
2012
18
Clinical features, pathogenesis and treatment of juvenile and adult dermatomyositis. (21947177)
2011
19
Type I interferon pathway in adult and juvenile dermatomyositis. (22192711)
2011
20
Clinical status and cardiovascular risk profile of adults with a history of juvenile dermatomyositis. (21784434)
2011
21
Clinical correlations with dermatomyositis-specific autoantibodies in adult Japanese patients with dermatomyositis: a multicenter cross-sectional study. (21482889)
2011
22
Longterm survival and associated risk factors in patients with adult-onset idiopathic inflammatory myopathies and amyopathic dermatomyositis: experience in a single institute in Japan. (21572147)
2011
23
Images in rheumatology. Severe adult-onset calcinosis in a patient with a history of juvenile dermatomyositis. (20040639)
2010
24
An extremely severe case of cutaneous calcinosis complicating adult dermatomyositis. (19076816)
2009
25
Damage extent and predictors in adult and juvenile dermatomyositis and polymyositis as determined with the myositis damage index. (19877055)
2009
26
Calcific panniculitis in adult-onset dermatomyositis. (20055847)
2009
27
Case of pneumatosis cystoides intestinalis in adult dermatomyositis. (18181780)
2008
28
Monocyte chemotactic protein-1 single nucleotide polymorphisms do not confer susceptibility for the development of adult onset polymyositis/dermatomyositis in UK Caucasians. (17065190)
2007
29
Adult clinically amyopathic dermatomyositis with rapid progressive interstitial lung disease: a retrospective cohort study. (17308858)
2007
30
Severe gastrointestinal inflammation in adult dermatomyositis: characterization of a novel clinical association. (17170621)
2006
31
Digital infarcts showing microangiopathy in adult dermatomyositis suggest severe pulmonary involvement and poor prognosis. (15214917)
2004
32
A helpful clinical sign predictive of cancer in adult dermatomyositis: cutaneous necrosis. (12707108)
2003
33
Associations of tumor necrosis factor alpha and HLA polymorphisms with adult dermatomyositis: implications for a unique pathogenesis. (12230503)
2002
34
Routine vs extensive malignancy search for adult dermatomyositis and polymyositis: a study of 40 patients. (12071815)
2002
35
Aerobic capacity in adult dermatomyositis/polymyositis patients and healthy controls. (10638867)
2000
36
Dystrophic calcification in adult dermatomyositis: neuroimage. (11146618)
2000
37
Subcutaneous emphysema with spontaneous pneumomediastinum and pneumothorax in adult dermatomyositis. (10091485)
1999
38
Adult dermatomyositis with livedo reticularis and multiple skin ulcers. (9731966)
1998
39
Epidermal necrosis as a predictive sign of malignancy in adult dermatomyositis. (9564590)
1998
40
Cutaneous ulcers of refractory adult dermatomyositis responsive to intravenous immunoglobulin. (9714905)
1998
41
Malignancy in adult dermatomyositis. (9466195)
1997
42
Retinopathy in adult dermatomyositis. (8965274)
1995
43
Severe acute form of adult dermatomyositis treated with cyclosporine. (1500250)
1992
44
Prognostic factors and predictive signs of malignancy in adult dermatomyositis. A study of 32 cases. (2334184)
1990
45
Early ultrastructural alterations in adult dermatomyositis. Capillary abnormalities precede other structural changes in muscle. (2614466)
1989
46
Prolonged spontaneous pneumomediastinum in adult dermatomyositis. (3662647)
1987
47
Jaccoud's arthropathy in adult dermatomyositis. (3533342)
1986
48
Spontaneous pneumomediastinum in adult dermatomyositis. (3767467)
1986
49
The prognosis of adult dermatomyositis. (5570265)
1971
50
Case for diagnosis: l. Scleredma adultorum 2. ?Scleromyxedema 3. ?Dermatomyositis. (5358131)
1969

Genetic Variations for Adult Dermatomyositis

Expression for genes affiliated with Adult Dermatomyositis

Sources:
1BioGPS, 15Gene Expression Omnibus DataSets
See all sources
Expression patterns in normal tissues for genes affiliated with Adult Dermatomyositis

Search GEO for disease gene expression data for Adult Dermatomyositis.

Pathways for genes affiliated with Adult Dermatomyositis

Sources:
38NCBI BioSystems Database, 54Reactome, 30KEGG, 12EMD Millipore, 52QIAGEN, 50PharmGKB
See all sources

Compounds for genes affiliated with Adult Dermatomyositis

Sources:
45Novoseek, 11DrugBank, 24HMDB, 29IUPHAR, 60Tocris Bioscience, 50PharmGKB, 2BitterDB
See all sources

Compounds related to Adult Dermatomyositis according to GeneCards/GeneDecks:

(show top 50)    (show all 89)
idCompoundScoreTop Affiliating Genes
1pentoxifylline45 1111.5VCAM1
2norepinephrine45 11 2412.5CHKB
3okt34510.1ICAM1, VCAM1
4mannitol45 1111.1ICAM1
5prednisolone45 29 1112.1PIK3C2A, CHKB
6thallium4510.0CHKB, PIK3C2A
7ro 31-75494510.0TNF, VCAM1
8alpha-hydroxybutyrate4510.0CHKB, PIK3C2A
9tetramethylpyrazine4510.0CHKB, ICAM1
10cdp571459.9TNF, ICAM1
11uric acid45 2410.9CHKB, PIK3C2A
12interferon gamma459.9TNF, ICAM1
13celastrol45 6010.8TNF, VCAM1
14sodium cromoglycate459.8VCAM1, ICAM1
15apocynin45 6010.7ICAM1, VCAM1, TNF
16polymyxin b459.7ICAM1, VCAM1, TNF
17groalpha459.6TNF, VCAM1, ICAM1
18budesonide45 50 1111.6TNF, VCAM1, ICAM1
19parthenolide45 210.6ICAM1, TNF, VCAM1
20cerivastatin45 50 29 1112.6PIK3C2A, ICAM1, CHKB
21diphenyleneiodonium459.6TNF, VCAM1, ICAM1
22neopterin459.6CHKB, ICAM1, TNF
23gliclazide45 50 1111.6ICAM1, INS, VCAM1
24melphalan45 1110.5CHKB, TNF, PIK3C2A
25gemfibrozil45 29 1111.5PIK3C2A, INS, CHKB
26pdtc459.5TNF, VCAM1, ICAM1
27alpha lipoic acid459.5VCAM1, INS, TNF
28bezafibrate45 29 1111.5PIK3C2A, CHKB, INS
29pioglitazone45 50 29 1112.4VCAM1, INS, TNF
30sp 60012545 6010.3TNF, ICAM1, VCAM1
31endotoxin459.3CHKB, TNF, VCAM1, ICAM1
32n-tosyl-l-phenylalanine chloromethyl ketone459.3TNF, ICAM1
33fluvastatin45 50 29 1112.3VCAM1, PIK3C2A, ICAM1, CHKB
34pravastatin45 50 29 11 2413.3PIK3C2A, VCAM1, ICAM1, CHKB
35n acetylcysteine459.3TNF, CHKB, VCAM1, ICAM1
36oxygen45 2410.3PIK3C2A, TNF, ICAM1
37superoxide45 2410.2CHKB, VCAM1, TNF
388-isoprostane459.2VCAM1, INS, ICAM1, TNF
39troglitazone45 29 60 1112.1ICAM1, TNF, VCAM1, INS
40rosiglitazone45 50 29 11 2413.1TNF, INS, VCAM1
41prostacyclin459.1ICAM1, TNF, PIK3C2A, VCAM1
42cyclosporin a45 29 6010.9CHKB, PIK3C2A, TNF, ICAM1
43atorvastatin45 50 29 11 2412.8VCAM1, TNF, CHKB, PIK3C2A, ICAM1
44simvastatin45 50 60 29 11 2413.8CHKB, TNF, PIK3C2A, ICAM1, VCAM1
45dexamethasone45 50 29 1111.7INS, TNF, VCAM1, CHKB, ICAM1
46vegf458.7PIK3C2A, VCAM1, ICAM1, CHKB, TNF
47fenofibrate45 50 1110.6INS, PIK3C2A, TNF, ICAM1, VCAM1
48ly294002458.6ICAM1, TNF, INS, VCAM1, PIK3C2A
49fibrinogen458.3PIK3C2A, CHKB, TNF, VCAM1, ICAM1, INS
50lactate458.3PIK3C2A, TNF, INS, VCAM1, ICAM1, CHKB

GO Terms for genes affiliated with Adult Dermatomyositis

Sources:
16Gene Ontology
See all sources

Cellular components related to Adult Dermatomyositis according to GeneCards/GeneDecks:

idNameGO IDScoreTop Affiliating Genes
1external side of plasma membraneGO:0098979.2VCAM1, TNF, ICAM1

Biological processes related to Adult Dermatomyositis according to GeneCards/GeneDecks:

(show all 12)
idNameGO IDScoreTop Affiliating Genes
1membrane to membrane dockingGO:0226149.9VCAM1, ICAM1
2leukocyte tethering or rollingGO:0509019.8VCAM1, TNF
3leukocyte cell-cell adhesionGO:0071599.8ICAM1, VCAM1
4cellular response to glucose stimulusGO:0713339.7VCAM1, ICAM1
5negative regulation of lipid catabolic processGO:0509959.7INS, TNF
6positive regulation of cytokine secretionGO:0507159.6TNF, INS
7positive regulation of mitosisGO:0458409.5TNF, INS
8heterophilic cell-cell adhesionGO:0071579.4VCAM1, ICAM1
9positive regulation of nitric oxide biosynthetic processGO:0454299.3INS, TNF, ICAM1
10positive regulation of NF-kappaB transcription factor activityGO:0510929.3ICAM1, TNF, INS
11protein sumoylationGO:0169259.2UBA2, SAE1
12cytokine-mediated signaling pathwayGO:0192219.1VCAM1, ICAM1, IFIT3

Molecular functions related to Adult Dermatomyositis according to GeneCards/GeneDecks:

idNameGO IDScoreTop Affiliating Genes
1SUMO activating enzyme activityGO:0199489.3SAE1, UBA2

Products for genes affiliated with Adult Dermatomyositis

  • Antibodies
  • Proteins
  • Lysates
  • Antibodies

Sources for Adult Dermatomyositis

3CDC
13ExPASy
14FMA
22GTR
23HGMD
24HMDB
25ICD10
26ICD10 via Orphanet
27ICD9CM
29IUPHAR
30KEGG
35MeSH
36MESH via Orphanet
37MGI
40NCIt
41NDF-RT
44NINDS
45Novoseek
47OMIM
48OMIM via Orphanet
51PubMed
52QIAGEN
58SNOMED-CT via Orphanet
61UMLS
62UMLS via Orphanet