MCID: ADL027
MIFTS: 41

Adult Dermatomyositis malady

Summaries for Adult Dermatomyositis

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MalaCards: Adult Dermatomyositis, also known as adult onset dermatomyositis, is related to dermatomyositis and inclusion body myositis. An important gene associated with Adult Dermatomyositis is CHKB (choline kinase beta), and among its related pathways are Cellular roles of Anthrax toxin and SUMOylation. The compounds pentoxifylline and norepinephrine have been mentioned in the context of this disorder. Affiliated tissues include lung, skin and testes.

Aliases & Classifications for Adult Dermatomyositis

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8Disease Ontology, 10DISEASES, 60UMLS
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Aliases & Descriptions:

adult dermatomyositis 8 10
adult onset dermatomyositis 8
adult type dermatomyositis 60


External Ids:

Disease Ontology8 DOID:14202

Related Diseases for Adult Dermatomyositis

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17GeneCards, 18GeneDecks
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Diseases in the Dermatomyositis family:

adult dermatomyositis

Diseases related to Adult Dermatomyositis via text searches within MalaCards or GeneCards/GeneDecks gene sharing:

(show top 50)    (show all 121)
idRelated DiseaseScoreTop Affiliating Genes
1dermatomyositis31.2VCAM1, CHKB, PIK3C2A, ICAM1
2inclusion body myositis29.9ICAM1, VCAM1
3myositis29.9PIK3C2A, VCAM1, CHKB, ICAM1
4calcinosis10.4
5pneumatosis cystoides intestinalis10.2
6lipodystrophy10.2
7systemic lupus erythematosus10.1
8adult syndrome10.1
9lupus erythematosus10.1
10panniculitis10.1
11sleep disorder10.0CHKB
12deficiency anemia10.0CHKB
13myocarditis10.0CHKB
14sickle cell disease10.0VCAM1
15dementia10.0PIK3C2A
16blindness10.0INS
17antiphospholipid syndrome10.0VCAM1
18morbid obesity10.0INS
19hyperthyroidism10.0INS
20malignant hyperthermia10.0PIK3C2A
21peripheral vascular disease10.0INS
22thrombocytopenia10.0PIK3C2A
23uremia10.0VCAM1
24polycystic ovary syndrome10.0INS
25essential hypertension10.0INS
26glucose intolerance10.0INS
27cholera10.0INS
28erysipelas10.0PIK3C2A
29lichen planus10.0ICAM1
30status asthmaticus10.0PIK3C2A
31sjogren's syndrome10.0ICAM1
32metabolic syndrome x10.0INS
33alopecia areata10.0ICAM1
34insulinoma10.0INS
35peritonitis10.0TNF
36interstitial lung disease10.0TNF
37acute myocardial infarction10.0PIK3C2A, CHKB
38myocardial infarction10.0CHKB, PIK3C2A
39ankylosing spondylitis10.0TNF
40myotonic dystrophy10.0PIK3C2A, CHKB
41erythema multiforme10.0ICAM1
42creatine phosphokinase, elevated serum10.0PIK3C2A, CHKB
43gas gangrene10.0CHKB, PIK3C2A
44metabolic acidosis10.0PIK3C2A, CHKB
45dilated cardiomyopathy10.0PIK3C2A, CHKB
46fatty liver disease10.0INS
47ectopic pregnancy10.0CHKB, PIK3C2A
48psoriatic arthritis10.0TNF
49hypercholesterolemia10.0VCAM1, INS
50hyperglycemia10.0VCAM1, INS

Graphical network of the top 20 diseases related to Adult Dermatomyositis:



Diseases related to adult dermatomyositis

Clinical Features for Adult Dermatomyositis

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Drugs & Therapeutics for Adult Dermatomyositis

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Sources:
5CenterWatch, 41NIH Clinical Center, 6ClinicalTrials
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Approved drugs:

Search CenterWatch for Adult Dermatomyositis

Drug clinical trials:

Search ClinicalTrials for Adult Dermatomyositis

Search NIH Clinical Center for Adult Dermatomyositis

Search CenterWatch for Adult Dermatomyositis

Genetic Tests for Adult Dermatomyositis

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Anatomical Context for Adult Dermatomyositis

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32MalaCards
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MalaCards organs/tissues related to Adult Dermatomyositis:

32
Lung, Skin, Testes, Skeletal muscle, Monocytes, T cells

Animal Models for Adult Dermatomyositis or affiliated genes

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Publications for Adult Dermatomyositis

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50PubMed
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Articles related to Adult Dermatomyositis:

(show top 50)    (show all 95)
idTitleAuthorsYear
1
Renal cell carcinoma-associated adult dermatomyositis treated laparoscopic nephrectomy. (24311917)
2013
2
Lacy reticular-pattern calcinosis in adult dermatomyositis. (23908532)
2013
3
Calcinosis cutis in adult patient with dermatomyositis. (24209983)
2013
4
Adult dermatomyositis associated with lipodystrophy. (23962582)
2013
5
A case of adult dermatomyositis associated with parainfluenza virus infection and Jo-1 antibody. (24341326)
2013
6
Predictors of clinical improvement in rituximab-treated refractory adult and juvenile dermatomyositis and adult polymyositis. (24249095)
2013
7
Suppression of soluble T cell-associated proteins by an anti-interferon-I+ monoclonal antibody in adult patients with dermatomyositis or polymyositis. (24357810)
2013
8
Therapy of calcinosis universalis complicating adult dermatomyositis. (24131911)
2013
9
Quality of life in adults with juvenile-onset dermatomyositis: a case-control study. (22328537)
2012
10
Adult dermatomyositis: experience of a Brazilian tertiary care center. (23223700)
2012
11
Two young-adult female cases of dermatomyositis with antibodies for transcriptional intermediary factor 1-I^. (22992252)
2012
12
Intravenous immunoglobulin therapy in adult patients with polymyositis/dermatomyositis: a systematic literature review. (22274797)
2012
13
Dysregulation of the type I interferon system in adult-onset clinically amyopathic dermatomyositis has a potential contribution to the development of interstitial lung disease. (23013528)
2012
14
Changes in novel biomarkers of disease activity in juvenile and adult dermatomyositis are sensitive biomarkers of disease course. (22886447)
2012
15
Morbidity and mortality in adult polymyositis and dermatomyositis. (22410829)
2012
16
Dermatomyositis associated with HIV-1 infection in a Nigerian adult female: a case report. (23066424)
2012
17
Dermatomyositis with extensive calcification in an adult. (22461949)
2012
18
Nicotinamide adenine dinucleotide tetrazolium reductase identifies microvasculature activation in muscle from adult patients with dermatomyositis. (22174214)
2012
19
Clinical features, pathogenesis and treatment of juvenile and adult dermatomyositis. (21947177)
2011
20
Type I interferon pathway in adult and juvenile dermatomyositis. (22192711)
2011
21
Adult dermatomyositis with severe polyneuropathy: does neuromyositis exist? (20229079)
2010
22
Images in rheumatology. Severe adult-onset calcinosis in a patient with a history of juvenile dermatomyositis. (20040639)
2010
23
Lipodystrophy in association with adult-onset dermatomyositis sine myositis: a rare manifestation. (20633786)
2010
24
An extremely severe case of cutaneous calcinosis complicating adult dermatomyositis. (19076816)
2009
25
Damage extent and predictors in adult and juvenile dermatomyositis and polymyositis as determined with the myositis damage index. (19877055)
2009
26
Calcific panniculitis in adult-onset dermatomyositis. (20055847)
2009
27
Clinical and human leucocyte antigen class II haplotype associations of autoantibodies to small ubiquitin-like modifier enzyme, a dermatomyositis-specific autoantigen target, in UK Caucasian adult-onset myositis. (18930994)
2009
28
Case of pneumatosis cystoides intestinalis in adult dermatomyositis. (18181780)
2008
29
Calcinosis cutis: a rare feature of adult dermatomyositis. (18319027)
2008
30
Monocyte chemotactic protein-1 single nucleotide polymorphisms do not confer susceptibility for the development of adult onset polymyositis/dermatomyositis in UK Caucasians. (17065190)
2007
31
Thrombotic microangiopathy in an adult patient with clinically amyopathic dermatomyositis complicated with interstitial lung disease. (18042598)
2007
32
Clinical significance of von Willebrand factor in patients with adult dermatomyositis. (15565394)
2005
33
Regression of cutis calcinosis with diltiazem in adult dermatomyositis. (15757822)
2005
34
Digital infarcts showing microangiopathy in adult dermatomyositis suggest severe pulmonary involvement and poor prognosis. (15214917)
2004
35
Refractory adult dermatomyositis with pneumatosis cystoides intestinalis treated with infliximab. (15317960)
2004
36
Dystrophic calcification in adult dermatomyositis: neuroimage. (11146618)
2000
37
A causal role for parvovirus B19 infection in adult dermatomyositis and other autoimmune syndromes. (11100810)
2000
38
Regression of calcinosis associated with adult dermatomyositis following diltiazem therapy. (10788545)
2000
39
Subcutaneous emphysema with spontaneous pneumomediastinum and pneumothorax in adult dermatomyositis. (10091485)
1999
40
Adult dermatomyositis with livedo reticularis and multiple skin ulcers. (9731966)
1998
41
A case of refractory adult dermatomyositis. (9651083)
1998
42
Epidermal necrosis as a predictive sign of malignancy in adult dermatomyositis. (9564590)
1998
43
Juvenile and adult dermatomyositis among the Chinese: a comparative study. (8299023)
1993
44
Cyclosporin A in adult dermatomyositis. (8495274)
1993
45
First case of pneumatosis cystoides intestinalis in adult dermatomyositis. (8478857)
1993
46
A case of adult dermatomyositis treated with cyclosporin A. (1458294)
1992
47
Severe acute form of adult dermatomyositis treated with cyclosporine. (1500250)
1992
48
Prognostic factors and predictive signs of malignancy in adult dermatomyositis. A study of 32 cases. (2334184)
1990
49
Recurrent pneumomediastinum in adult dermatomyositis. (2724255)
1989
50
Prolonged spontaneous pneumomediastinum in adult dermatomyositis. (3662647)
1987

Genetic Variations for Adult Dermatomyositis

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Expression for genes affiliated with Adult Dermatomyositis

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Sources:
1BioGPS, 15Gene Expression Omnibus DataSets
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Expression patterns in normal tissues for genes affiliated with Adult Dermatomyositis

Search GEO for disease gene expression data for Adult Dermatomyositis.

Pathways for genes affiliated with Adult Dermatomyositis

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Sources:
37NCBI BioSystems Database, 53Reactome, 29KEGG, 51QIAGEN, 12EMD Millipore, 49PharmGKB
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Compounds for genes affiliated with Adult Dermatomyositis

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44Novoseek, 11DrugBank, 24HMDB, 28IUPHAR, 59Tocris Bioscience, 49PharmGKB, 2BitterDB
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Compounds related to Adult Dermatomyositis according to GeneCards/GeneDecks:

(show top 50)    (show all 89)
idCompoundScoreTop Affiliating Genes
1pentoxifylline44 1111.5VCAM1
2norepinephrine44 11 2412.5CHKB
3okt34410.1ICAM1, VCAM1
4mannitol44 1111.1ICAM1
5prednisolone44 28 1112.1PIK3C2A, CHKB
6thallium4410.0CHKB, PIK3C2A
7ro 31-75494410.0TNF, VCAM1
8alpha-hydroxybutyrate4410.0CHKB, PIK3C2A
9tetramethylpyrazine4410.0CHKB, ICAM1
10cdp571449.9TNF, ICAM1
11uric acid44 2410.9CHKB, PIK3C2A
12interferon gamma449.9TNF, ICAM1
13celastrol44 5910.8TNF, VCAM1
14sodium cromoglycate449.8VCAM1, ICAM1
15apocynin44 5910.7ICAM1, VCAM1, TNF
16polymyxin b449.7ICAM1, VCAM1, TNF
17groalpha449.6TNF, VCAM1, ICAM1
18budesonide44 49 1111.6TNF, VCAM1, ICAM1
19parthenolide44 210.6ICAM1, TNF, VCAM1
20cerivastatin44 49 28 1112.6PIK3C2A, ICAM1, CHKB
21diphenyleneiodonium449.6TNF, VCAM1, ICAM1
22neopterin449.6CHKB, ICAM1, TNF
23gliclazide44 49 1111.6ICAM1, INS, VCAM1
24melphalan44 1110.5CHKB, TNF, PIK3C2A
25gemfibrozil44 28 1111.5PIK3C2A, INS, CHKB
26pdtc449.5TNF, VCAM1, ICAM1
27alpha lipoic acid449.5VCAM1, INS, TNF
28bezafibrate44 28 1111.5PIK3C2A, CHKB, INS
29pioglitazone44 49 28 1112.4VCAM1, INS, TNF
30sp 60012544 5910.3TNF, ICAM1, VCAM1
31endotoxin449.3CHKB, TNF, VCAM1, ICAM1
32n-tosyl-l-phenylalanine chloromethyl ketone449.3TNF, ICAM1
33fluvastatin44 49 28 1112.3VCAM1, PIK3C2A, ICAM1, CHKB
34pravastatin44 49 28 11 2413.3PIK3C2A, VCAM1, ICAM1, CHKB
35n acetylcysteine449.3TNF, CHKB, VCAM1, ICAM1
36oxygen44 2410.3PIK3C2A, TNF, ICAM1
37superoxide44 2410.2CHKB, VCAM1, TNF
388-isoprostane449.2VCAM1, INS, ICAM1, TNF
39troglitazone44 28 59 1112.1ICAM1, TNF, VCAM1, INS
40rosiglitazone44 49 28 11 2413.1TNF, INS, VCAM1
41prostacyclin449.1ICAM1, TNF, PIK3C2A, VCAM1
42cyclosporin a44 28 5910.9CHKB, PIK3C2A, TNF, ICAM1
43atorvastatin44 49 28 11 2412.8VCAM1, TNF, CHKB, PIK3C2A, ICAM1
44simvastatin44 49 59 28 11 2413.8CHKB, TNF, PIK3C2A, ICAM1, VCAM1
45dexamethasone44 49 28 1111.7INS, TNF, VCAM1, CHKB, ICAM1
46vegf448.7PIK3C2A, VCAM1, ICAM1, CHKB, TNF
47fenofibrate44 49 1110.6INS, PIK3C2A, TNF, ICAM1, VCAM1
48ly294002448.6ICAM1, TNF, INS, VCAM1, PIK3C2A
49fibrinogen448.3PIK3C2A, CHKB, TNF, VCAM1, ICAM1, INS
50lactate448.3PIK3C2A, TNF, INS, VCAM1, ICAM1, CHKB

GO Terms for genes affiliated with Adult Dermatomyositis

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16Gene Ontology
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Cellular components related to Adult Dermatomyositis according to GeneCards/GeneDecks:

idNameGO IDScoreTop Affiliating Genes
1external side of plasma membraneGO:0098979.2VCAM1, TNF, ICAM1

Biological processes related to Adult Dermatomyositis according to GeneCards/GeneDecks:

(show all 12)
idNameGO IDScoreTop Affiliating Genes
1membrane to membrane dockingGO:0226149.9VCAM1, ICAM1
2leukocyte tethering or rollingGO:0509019.8VCAM1, TNF
3leukocyte cell-cell adhesionGO:0071599.8ICAM1, VCAM1
4cellular response to glucose stimulusGO:0713339.7VCAM1, ICAM1
5negative regulation of lipid catabolic processGO:0509959.7INS, TNF
6positive regulation of cytokine secretionGO:0507159.6TNF, INS
7positive regulation of mitosisGO:0458409.5TNF, INS
8heterophilic cell-cell adhesionGO:0071579.4VCAM1, ICAM1
9positive regulation of nitric oxide biosynthetic processGO:0454299.3INS, TNF, ICAM1
10positive regulation of NF-kappaB transcription factor activityGO:0510929.3ICAM1, TNF, INS
11protein sumoylationGO:0169259.2UBA2, SAE1
12cytokine-mediated signaling pathwayGO:0192219.1VCAM1, ICAM1, IFIT3

Molecular functions related to Adult Dermatomyositis according to GeneCards/GeneDecks:

idNameGO IDScoreTop Affiliating Genes
1SUMO activating enzyme activityGO:0199489.3SAE1, UBA2

Products for genes affiliated with Adult Dermatomyositis

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  • Antibodies
  • Proteins
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  • Antibodies

Sources for Adult Dermatomyositis

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3CDC
13ExPASy
14FMA
22GTR
23HGMD
24HMDB
25ICD10
26ICD10 via Orphanet
27ICD9CM
28IUPHAR
29KEGG
34MeSH
35MESH via Orphanet
36MGI
39NCIt
40NDF-RT
43NINDS
44Novoseek
46OMIM
47OMIM via Orphanet
50PubMed
51QIAGEN
57SNOMED-CT via Orphanet
60UMLS
61UMLS via Orphanet