MCID: ADL027
MIFTS: 39

Adult Dermatomyositis malady

Skin diseases, Rare diseases, Neuronal diseases, Nephrological diseases, Bone diseases categories

Summaries for Adult Dermatomyositis

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MalaCards based summary: Adult Dermatomyositis, also known as adult onset dermatomyositis, is related to calcinosis and dermatomyositis. An important gene associated with Adult Dermatomyositis is CHKB (choline kinase beta), and among its related pathways are Immune response Role of integrins in NK cells cytotoxicity and Development VEGF signaling and activation. The compounds thallium and alpha-hydroxybutyrate have been mentioned in the context of this disorder. Affiliated tissues include skin, and related mouse phenotypes are muscle and hematopoietic system.

Aliases & Classifications for Adult Dermatomyositis

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Adult Dermatomyositis, Aliases & Descriptions:

Name: Adult Dermatomyositis 9 11
Adult Onset Dermatomyositis 9
 
Adult Type Dermatomyositis 60


Classifications:



External Ids:

Disease Ontology9 DOID:14202

Related Diseases for Adult Dermatomyositis

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Diseases in the Dermatomyositis family:

adult dermatomyositis

Diseases related to Adult Dermatomyositis via text searches within MalaCards or GeneCards Suite gene sharing:

(show top 50)    (show all 82)
idRelated DiseaseScoreTop Affiliating Genes
1calcinosis31.3PIK3C2A
2dermatomyositis31.1PIK3C2A, VCAM1, CHKB, ICAM1
3inclusion body myositis30.3ICAM1, VCAM1
4systemic lupus erythematosus30.2ICAM1, VCAM1, TNF
5polymyositis30.2ICAM1, CHKB, VCAM1, PIK3C2A
6myositis29.8ICAM1, CHKB, VCAM1, PIK3C2A
7erysipelas10.4PIK3C2A
8status asthmaticus10.4PIK3C2A
9creatine phosphokinase, elevated serum10.3PIK3C2A, CHKB
10gas gangrene10.3PIK3C2A, CHKB
11ectopic pregnancy10.3PIK3C2A, CHKB
12pericardial effusion10.3CHKB, PIK3C2A
13neuroleptic malignant syndrome10.3CHKB, PIK3C2A
14pneumatosis cystoides intestinalis10.3
15lipodystrophy10.3
16lupus erythematosus10.3
17middle ear cholesteatoma10.2CHKB, ICAM1
18leukostasis10.2VCAM1, ICAM1
19rheumatoid vasculitis10.2VCAM1, ICAM1
20acute kidney failure10.2CHKB, PIK3C2A
21arteriosclerosis obliterans10.2VCAM1, ICAM1
22henoch-schoenlein purpura10.2ICAM1, VCAM1
23galactosemia10.2CHKB, PIK3C2A
24oral lichen planus10.2VCAM1, ICAM1
25vernal keratoconjunctivitis10.2ICAM1, VCAM1
26metabolic acidosis10.2PIK3C2A, CHKB
27duchenne muscular dystrophy10.1CHKB, PIK3C2A
28panniculitis10.1
29alcoholic hepatitis10.1ICAM1, TNF
30arteriosclerosis10.1VCAM1, ICAM1
31malaria10.1TNF, ICAM1
32pulmonary sarcoidosis10.1TNF, ICAM1
33microvascular complications of diabetes 110.1ICAM1, VCAM1
34myotonic dystrophy10.1PIK3C2A, CHKB
35rhinitis10.1ICAM1, VCAM1
36periodontal disease10.1TNF, ICAM1
37hashimoto thyroiditis10.1ICAM1, CHKB
38lupus nephritis10.1ICAM1, VCAM1
39arthritis10.1TNF, ICAM1
40diabetic ketoacidosis10.1INS, PIK3C2A
41hypokalemia10.0INS, PIK3C2A
42monocytic leukemia10.0VCAM1, TNF
43hyperuricemia10.0PIK3C2A, INS
44pseudoxanthoma elasticum10.0
45renal cell carcinoma10.0
46childhood type dermatomyositis10.0
47arthropathy10.0
48esophagitis10.0
49pneumothorax10.0
50polyneuropathy10.0

Graphical network of the top 20 diseases related to Adult Dermatomyositis:



Diseases related to adult dermatomyositis

Symptoms for Adult Dermatomyositis

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Drugs & Therapeutics for Adult Dermatomyositis

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Drug clinical trials:

Search ClinicalTrials for Adult Dermatomyositis

Search NIH Clinical Center for Adult Dermatomyositis

Genetic Tests for Adult Dermatomyositis

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Anatomical Context for Adult Dermatomyositis

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MalaCards organs/tissues related to Adult Dermatomyositis:

31
Skin

Animal Models for Adult Dermatomyositis or affiliated genes

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MGI Mouse Phenotypes related to Adult Dermatomyositis:

35
idDescriptionMGI Source AccessionScoreTop Affiliating Genes
1MP:00053698.8ICAM1, CHKB, TNF, INS
2MP:00053977.9PIK3C2A, INS, TNF, VCAM1, ICAM1
3MP:00053767.9PIK3C2A, INS, TNF, VCAM1, CHKB, ICAM1
4MP:00053787.4UBA2, ICAM1, VCAM1, TNF, INS, PIK3C2A
5MP:00107687.3PIK3C2A, INS, TNF, VCAM1, ICAM1, UBA2

Publications for Adult Dermatomyositis

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Articles related to Adult Dermatomyositis:

(show top 50)    (show all 63)
idTitleAuthorsYear
1
IL-1RN VNTR Polymorphism in Adult Dermatomyositis and Systemic Lupus Erythematosus. (25328514)
2014
2
A case of adult dermatomyositis with calcinosis universalis. (25400376)
2014
3
HLA class II alleles may influence susceptibility to adult dermatomyositis and polymyositis in a Han Chinese population. (24894810)
2014
4
Adult dermatomyositis with bleeding ulcer in the pharynx. (25328739)
2014
5
Renal cell carcinoma-associated adult dermatomyositis treated laparoscopic nephrectomy. (24311917)
2013
6
Lacy reticular-pattern calcinosis in adult dermatomyositis. (23908532)
2013
7
Adult dermatomyositis associated with lipodystrophy. (23962582)
2013
8
A case of adult dermatomyositis associated with parainfluenza virus infection and Jo-1 antibody. (24341326)
2013
9
Analysis of metabolic syndrome in adult dermatomyositis with a focus on cardiovascular disease. (23139205)
2013
10
Focal lipodystrophy without metabolic disorders in adult dermatomyositis. (22804743)
2013
11
Marked improvement of calcinosis in adult dermatomyositis with etidronate therapy. (21710176)
2012
12
Adult dermatomyositis: experience of a Brazilian tertiary care center. (23223700)
2012
13
Changes in novel biomarkers of disease activity in juvenile and adult dermatomyositis are sensitive biomarkers of disease course. (22886447)
2012
14
Clinical features, pathogenesis and treatment of juvenile and adult dermatomyositis. (21947177)
2011
15
Adult dermatomyositis with severe polyneuropathy: does neuromyositis exist? (20229079)
2010
16
An extremely severe case of cutaneous calcinosis complicating adult dermatomyositis. (19076816)
2009
17
Clinical characteristics and outcomes of juvenile and adult dermatomyositis. (19654958)
2009
18
Case of pneumatosis cystoides intestinalis in adult dermatomyositis. (18181780)
2008
19
Lipodystrophy and metabolic abnormalities in a case of adult dermatomyositis. (17938031)
2007
20
Acute-onset adult dermatomyositis presenting with erythroderma and diplopia. (17868397)
2007
21
Difference in adhesion molecule expression (ICAM-1 and VCAM-1) in juvenile and adult dermatomyositis, polymyositis and inclusion body myositis. (16431335)
2006
22
Disease course, frequency of relapses and survival of 73 patients with juvenile or adult dermatomyositis. (15789887)
2005
23
Clinical significance of von Willebrand factor in patients with adult dermatomyositis. (15565394)
2005
24
Regression of cutis calcinosis with diltiazem in adult dermatomyositis. (15757822)
2005
25
Pruritus in adult dermatomyositis. (15115510)
2004
26
Uncertainties in the pathogenesis of adult dermatomyositis. (15167072)
2004
27
Digital infarcts showing microangiopathy in adult dermatomyositis suggest severe pulmonary involvement and poor prognosis. (15214917)
2004
28
A helpful clinical sign predictive of cancer in adult dermatomyositis: cutaneous necrosis. (12707108)
2003
29
Pseudoxanthoma elasticum (PXE)-like calcification in adult dermatomyositis. (12184640)
2002
30
Associations of tumor necrosis factor alpha and HLA polymorphisms with adult dermatomyositis: implications for a unique pathogenesis. (12230503)
2002
31
Familial adult dermatomyositis. (11251585)
2001
32
Aerobic capacity in adult dermatomyositis/polymyositis patients and healthy controls. (10638867)
2000
33
Dystrophic calcification in adult dermatomyositis: neuroimage. (11146618)
2000
34
A causal role for parvovirus B19 infection in adult dermatomyositis and other autoimmune syndromes. (11100810)
2000
35
Regression of calcinosis associated with adult dermatomyositis following diltiazem therapy. (10788545)
2000
36
Subcutaneous emphysema with spontaneous pneumomediastinum and pneumothorax in adult dermatomyositis. (10091485)
1999
37
Adult dermatomyositis with livedo reticularis and multiple skin ulcers. (9731966)
1998
38
A case of refractory adult dermatomyositis. (9651083)
1998
39
Epidermal necrosis as a predictive sign of malignancy in adult dermatomyositis. (9564590)
1998
40
Spontaneous esophageal rupture in adult dermatomyositis. (8971517)
1996
41
Retinopathy in adult dermatomyositis. (8965274)
1995
42
Juvenile and adult dermatomyositis among the Chinese: a comparative study. (8299023)
1993
43
Cyclosporin A in adult dermatomyositis. (8495274)
1993
44
A case of adult dermatomyositis treated with cyclosporin A. (1458294)
1992
45
Severe acute form of adult dermatomyositis treated with cyclosporine. (1500250)
1992
46
Prognostic factors and predictive signs of malignancy in adult dermatomyositis. A study of 32 cases. (2334184)
1990
47
Early ultrastructural alterations in adult dermatomyositis. Capillary abnormalities precede other structural changes in muscle. (2614466)
1989
48
Prolonged spontaneous pneumomediastinum in adult dermatomyositis. (3662647)
1987
49
Jaccoud's arthropathy in adult dermatomyositis. (3533342)
1986
50
The prognosis of adult dermatomyositis. (5570265)
1971

Variations for Adult Dermatomyositis

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Expression for genes affiliated with Adult Dermatomyositis

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Search GEO for disease gene expression data for Adult Dermatomyositis.

Pathways for genes affiliated with Adult Dermatomyositis

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Pathways related to Adult Dermatomyositis according to GeneCards Suite gene sharing:

(show all 21)
idSuper pathways (with members indented)ScoreTop Affiliating Genes
19.7ICAM1, VCAM1
2
Show member pathways
Development VEGF signaling via VEGFR2 generic cascades58
9.7ICAM1, VCAM1
39.7ICAM1, VCAM1
49.7VCAM1, ICAM1
59.6VCAM1, TNF
69.5ICAM1, TNF
7
Show member pathways
9.3UBA2, SAE1
8
Show member pathways
DNA damage Role of SUMO in p53 regulation58
9.3UBA2, SAE1
99.2ICAM1, VCAM1, TNF
109.2ICAM1, VCAM1, TNF
119.2ICAM1, VCAM1, TNF
129.2ICAM1, VCAM1, TNF
139.2TNF, VCAM1, ICAM1
149.2ICAM1, VCAM1, TNF
159.2TNF, VCAM1, ICAM1
16
Show member pathways
9.1INS, TNF, ICAM1
17
Show member pathways
thioredoxin pathway36
9.1ICAM1, TNF, INS
18
Show member pathways
9.1VCAM1, ICAM1, IFIT3
19
Show member pathways
9.0PIK3C2A, INS, TNF
20
Show member pathways
8.8TNF, SAE1, UBA2
21
Show member pathways
8.5UBA2, ICAM1, SAE1, VCAM1

Compounds for genes affiliated with Adult Dermatomyositis

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Compounds related to Adult Dermatomyositis according to GeneCards Suite gene sharing:

(show top 50)    (show all 120)
idCompoundScoreTop Affiliating Genes
1thallium439.9PIK3C2A, CHKB
2alpha-hydroxybutyrate439.9PIK3C2A, CHKB
3ro 31-7549439.9TNF, VCAM1
4tetramethylpyrazine439.9ICAM1, CHKB
5cdp571439.8ICAM1, TNF
6interferon gamma439.7ICAM1, TNF
7celastrol43 5910.7TNF, VCAM1
8sodium cromoglycate439.7ICAM1, VCAM1
9gliclazide43 49 1211.7VCAM1, INS, ICAM1
10cerivastatin49 43 28 1212.6PIK3C2A, CHKB, ICAM1
11apocynin43 5910.6VCAM1, TNF, ICAM1
12polymyxin b439.6TNF, ICAM1, VCAM1
13groalpha439.6ICAM1, TNF, VCAM1
14gemfibrozil28 43 1211.6PIK3C2A, INS, CHKB
15okt3439.6VCAM1, TNF, ICAM1
16budesonide43 49 1211.6VCAM1, TNF, ICAM1
17parthenolide43 210.6TNF, ICAM1, VCAM1
18bezafibrate43 28 1211.6CHKB, PIK3C2A, INS
19neopterin439.6TNF, ICAM1, CHKB
20diphenyleneiodonium439.5TNF, ICAM1, VCAM1
21pentoxifylline43 1210.5TNF, VCAM1, ICAM1
22alpha lipoic acid439.5VCAM1, TNF, INS
23pdtc439.5TNF, VCAM1, ICAM1
24melphalan43 49 1211.4PIK3C2A, TNF, CHKB
25pioglitazone28 43 49 1212.4INS, TNF, VCAM1
26uric acid43 2410.4PIK3C2A, CHKB, INS
27fluvastatin43 49 28 1212.3ICAM1, VCAM1, CHKB, PIK3C2A
28pravastatin43 49 28 24 1213.3CHKB, VCAM1, PIK3C2A, ICAM1
29mannitol43 1210.3VCAM1, CHKB, ICAM1
30endotoxin439.3TNF, VCAM1, ICAM1, CHKB
31sp 60012543 5910.2TNF, VCAM1, ICAM1
32n acetylcysteine439.2VCAM1, TNF, ICAM1, CHKB
33prednisolone43 28 1211.2PIK3C2A, TNF, VCAM1, CHKB
348-isoprostane439.2VCAM1, INS, TNF, ICAM1
35norepinephrine43 24 1211.1PIK3C2A, INS, VCAM1, CHKB
36troglitazone43 28 59 1212.1ICAM1, TNF, VCAM1, INS
37prostacyclin439.1PIK3C2A, ICAM1, TNF, VCAM1
38pge2439.1ICAM1, CHKB, VCAM1, TNF
39cyclosporin a43 28 5910.9CHKB, ICAM1, TNF, PIK3C2A
40rosiglitazone28 43 49 24 1212.8TNF, VCAM1, INS
41atorvastatin43 49 28 24 1212.8CHKB, VCAM1, ICAM1, TNF, PIK3C2A
42simvastatin43 49 59 28 24 1213.8VCAM1, TNF, PIK3C2A, CHKB, ICAM1
43dexamethasone43 49 28 1211.8ICAM1, VCAM1, TNF, INS, CHKB
44superoxide43 249.7TNF, PIK3C2A, VCAM1, CHKB
45vegf438.7ICAM1, CHKB, PIK3C2A, TNF, VCAM1
46fenofibrate43 49 1210.6PIK3C2A, INS, VCAM1, ICAM1, TNF
47ly294002438.6ICAM1, PIK3C2A, VCAM1, INS, TNF
48oxygen43 249.6PIK3C2A, ICAM1, VCAM1, CHKB, TNF
49fibrinogen438.3PIK3C2A, INS, TNF, VCAM1, CHKB, ICAM1
50lactate438.3ICAM1, CHKB, VCAM1, TNF, INS, PIK3C2A

GO Terms for genes affiliated with Adult Dermatomyositis

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Cellular components related to Adult Dermatomyositis according to GeneCards Suite gene sharing:

idNameGO IDScoreTop Affiliating Genes
1external side of plasma membraneGO:00098978.9ICAM1, VCAM1, TNF
2extracellular spaceGO:00056158.7ICAM1, VCAM1, TNF, INS

Biological processes related to Adult Dermatomyositis according to GeneCards Suite gene sharing:

(show all 17)
idNameGO IDScoreTop Affiliating Genes
1membrane to membrane dockingGO:002261410.0ICAM1, VCAM1
2leukocyte cell-cell adhesionGO:00071599.9ICAM1, VCAM1
3leukocyte tethering or rollingGO:00509019.9VCAM1, TNF
4heterophilic cell-cell adhesionGO:00071579.8ICAM1, VCAM1
5cellular response to glucose stimulusGO:00713339.8ICAM1, VCAM1
6negative regulation of lipid catabolic processGO:00509959.8INS, TNF
7positive regulation of cytokine secretionGO:00507159.7TNF, INS
8response to ionizing radiationGO:00102129.7ICAM1, VCAM1
9interferon-gamma-mediated signaling pathwayGO:00603339.7ICAM1, VCAM1
10positive regulation of mitosisGO:00458409.7TNF, INS
11protein sumoylationGO:00169259.5SAE1, UBA2
12positive regulation of nitric oxide biosynthetic processGO:00454299.4ICAM1, TNF, INS
13cellular response to tumor necrosis factorGO:00713569.4ICAM1, VCAM1
14positive regulation of NF-kappaB transcription factor activityGO:00510929.4INS, TNF, ICAM1
15cytokine-mediated signaling pathwayGO:00192219.3IFIT3, ICAM1, VCAM1
16extracellular matrix organizationGO:00301989.2TNF, VCAM1, ICAM1
17positive regulation of catalytic activityGO:00430859.2UBA2, SAE1

Molecular functions related to Adult Dermatomyositis according to GeneCards Suite gene sharing:

idNameGO IDScoreTop Affiliating Genes
1protease bindingGO:00020209.5TNF, INS
2SUMO activating enzyme activityGO:00199489.2UBA2, SAE1
3enzyme activator activityGO:00080479.0UBA2, SAE1

Products for genes affiliated with Adult Dermatomyositis

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Sources for Adult Dermatomyositis

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3CDC
13ExPASy
14FMA
22GTR
23HGMD
24HMDB
25ICD10
26ICD10 via Orphanet
27ICD9CM
28IUPHAR
29KEGG
33MeSH
34MESH via Orphanet
35MGI
38NCIt
39NDF-RT
42NINDS
43Novoseek
45OMIM
46OMIM via Orphanet
50PubMed
51QIAGEN
56SNOMED-CT via Orphanet
60UMLS
61UMLS via Orphanet