MCID: ADL019
MIFTS: 37

Adult Fibrosarcoma

Categories: Rare diseases, Bone diseases, Cancer diseases

Aliases & Classifications for Adult Fibrosarcoma

MalaCards integrated aliases for Adult Fibrosarcoma:

Name: Adult Fibrosarcoma 12 14 69

Classifications:



External Ids:

Disease Ontology 12 DOID:3516
NCIt 46 C7809
UMLS 69 C0278595

Summaries for Adult Fibrosarcoma

MalaCards based summary : Adult Fibrosarcoma is related to adult mesoblastic nephroma and pediatric fibrosarcoma. An important gene associated with Adult Fibrosarcoma is NTRK3 (Neurotrophic Receptor Tyrosine Kinase 3), and among its related pathways/superpathways are Vemurafenib Pathway, Pharmacodynamics and G-protein signaling_H-RAS regulation pathway. The drugs Doxorubicin and Ifosfamide have been mentioned in the context of this disorder. Affiliated tissues include lung and liver, and related phenotypes are cardiovascular system and growth/size/body region

Related Diseases for Adult Fibrosarcoma

Diseases in the Fibrosarcoma family:

Adult Fibrosarcoma Congenital Fibrosarcoma

Diseases related to Adult Fibrosarcoma via text searches within MalaCards or GeneCards Suite gene sharing:

(show top 50) (show all 55)
# Related Disease Score Top Affiliating Genes
1 adult mesoblastic nephroma 10.4 ETV6 NTRK3
2 pediatric fibrosarcoma 10.4 ETV6 NTRK3
3 cellular congenital mesoblastic nephroma 10.4 ETV6 NTRK3
4 congenital fibrosarcoma 10.4 ETV6 NTRK3
5 ring chromosome 4 10.4 COL1A1 PDGFB
6 malignant triton tumor 10.4 MB MYOD1
7 bednar tumor 10.4 COL1A1 PDGFB
8 mesenchymoma 10.3 MB MYOD1
9 spindle cell rhabdomyosarcoma 10.3 MB MYOD1
10 dermis tumor 10.3 COL1A1 PDGFB
11 breast secretory carcinoma 10.3 ETV6 NTRK3
12 pleomorphic rhabdomyosarcoma 10.3 MB MYOD1
13 mixed liposarcoma 10.2 MB PDGFB
14 kidney rhabdoid cancer 10.2 MB WT1
15 connective tissue cancer 10.2 COL1A1 NTRK3 PDGFB
16 skin sarcoma 10.2 COL1A1 PDGFB
17 osteogenesis imperfecta, type v 10.1 COL1A1 FDPS
18 congenital mesoblastic nephroma 10.1 ETV6 NTRK3 WT1
19 malignant fibrous histiocytoma of bone 10.1 HRAS MYOD1
20 bone ewing's sarcoma 10.1 PDGFB WT1
21 melanomatosis 10.1 HRAS WT1
22 gallbladder sarcoma 10.0 MYOD1 MYOG
23 rhabdoid cancer 10.0 MB MYOD1 WT1
24 undifferentiated embryonal sarcoma of the liver 10.0 MYOD1 MYOG
25 uterine sarcoma 10.0 MB WT1
26 inflammatory leiomyosarcoma 10.0 MYOD1 MYOG
27 mixed cell type cancer 10.0 HRAS MB
28 conventional leiomyosarcoma 10.0 MYOD1 MYOG
29 hereditary wilms' tumor 10.0 HRAS WT1
30 orbit rhabdomyosarcoma 10.0 MB MYOG
31 differentiated thyroid carcinoma 10.0 ETV6 HRAS NTRK3
32 fibrosarcoma 9.9
33 core binding factor acute myeloid leukemia 9.9 HRAS WT1
34 embryonal sarcoma 9.9 MYOD1 MYOG
35 hematologic cancer 9.8 ETV6 HRAS WT1
36 leukemia, chronic myeloid 9.8 ETV6 HRAS WT1
37 extraosseous ewing's sarcoma 9.8 MYOD1 MYOG
38 malignant ovarian surface epithelial-stromal neoplasm 9.8 HRAS WT1
39 breast rhabdomyosarcoma 9.8 MB MYOD1 MYOG
40 medullomyoblastoma 9.8 MB MYOD1 MYOG
41 embryonal rhabdomyosarcoma 9.8 MB MYOD1 MYOG
42 skeletal muscle cancer 9.8 MB MYOD1 MYOG
43 spindle cell liposarcoma 9.7 MYOD1 MYOG WT1
44 nephrogenic adenofibroma 9.7 MYOD1 MYOG WT1
45 desmoplastic small round cell tumor 9.7 MYOD1 MYOG WT1
46 ovary epithelial cancer 9.7 HRAS WT1
47 rhabdomyosarcoma 9.7 MB MYOD1 MYOG
48 skin benign neoplasm 9.6 COL1A1 HRAS
49 dermatofibrosarcoma protuberans 9.6
50 leiomyosarcoma 9.6 MB MYOG WT1

Graphical network of the top 20 diseases related to Adult Fibrosarcoma:



Diseases related to Adult Fibrosarcoma

Symptoms & Phenotypes for Adult Fibrosarcoma

MGI Mouse Phenotypes related to Adult Fibrosarcoma:

43
# Description MGI Source Accession Score Top Affiliating Genes
1 cardiovascular system MP:0005385 10.06 ETV6 NTRK3 HRAS PDGFB MB COL1A1
2 growth/size/body region MP:0005378 10.06 MYOG ETV6 NTRK3 HRAS PDGFB MB
3 mortality/aging MP:0010768 10.02 COL1A1 MYOD1 ETV6 MYOG NTRK3 HRAS
4 embryo MP:0005380 9.91 COL1A1 MYOG ETV6 MB WT1 PDGFB
5 muscle MP:0005369 9.8 MYOD1 MYOG PDGFB MB COL1A1 WT1
6 no phenotypic analysis MP:0003012 9.76 MYOG ETV6 NTRK3 HRAS PDGFB COL1A1
7 neoplasm MP:0002006 9.65 COL1A1 MYOD1 ETV6 HRAS WT1
8 normal MP:0002873 9.5 MYOG ETV6 NTRK3 HRAS COL1A1 MYOD1
9 respiratory system MP:0005388 9.23 MYOG NTRK3 HRAS PDGFB MB COL1A1

Drugs & Therapeutics for Adult Fibrosarcoma

Drugs for Adult Fibrosarcoma (from DrugBank, HMDB, Dgidb, PharmGKB, IUPHAR, NovoSeek, BitterDB):

(show all 48)
# Name Status Phase Clinical Trials Cas Number PubChem Id
1
Doxorubicin Approved, Investigational Phase 3,Phase 2,Phase 1 23214-92-8 31703
2
Ifosfamide Approved Phase 3,Phase 2,Phase 1 3778-73-2 3690
3
Mechlorethamine Approved, Investigational Phase 3,Phase 2,Phase 1 51-75-2 4033
4
Lenograstim Approved, Investigational Phase 3 135968-09-1
5
Etoposide Approved Phase 3 33419-42-0 36462
6
Trabectedin Approved, Investigational Phase 2, Phase 3 114899-77-3 108150
7
Cyclophosphamide Approved, Investigational Phase 2, Phase 3 50-18-0, 6055-19-2 2907
8
Doxil Approved June 1999 Phase 3,Phase 2,Phase 1 31703
9 Alkylating Agents Phase 3,Phase 2,Phase 1
10 Anti-Bacterial Agents Phase 3,Phase 2,Phase 1
11 Antibiotics, Antitubercular Phase 3,Phase 2,Phase 1
12 Topoisomerase Inhibitors Phase 3,Phase 2,Phase 1
13 Isophosphamide mustard Phase 3,Phase 2,Phase 1 0
14 Antineoplastic Agents, Phytogenic Phase 3,Phase 2
15 Etoposide phosphate Phase 3
16
Dacarbazine Approved, Investigational Phase 2 4342-03-4 5351166
17
Temozolomide Approved, Investigational Phase 2 85622-93-1 5394
18
Romidepsin Approved, Investigational Phase 2 128517-07-7 5352062
19
Sunitinib Approved, Investigational Phase 2 341031-54-7, 557795-19-4 5329102
20
Gemcitabine Approved Phase 2 95058-81-4 60750
21
Saracatinib Investigational Phase 2 379231-04-6
22
Camptothecin Experimental Phase 2 7689-03-4
23 Exatecan Investigational Phase 2 171335-80-1
24 Soblidotin Investigational Phase 2 149606-27-9
25 Imatinib Mesylate Phase 2,Phase 1 123596
26 Protein Kinase Inhibitors Phase 2,Phase 1
27 topoisomerase I inhibitors Phase 2
28 Angiogenesis Inhibitors Phase 2
29 Angiogenesis Modulating Agents Phase 2
30 Immunosuppressive Agents Phase 2
31 Anti-Infective Agents Phase 2
32 Antimetabolites Phase 2
33 Antimetabolites, Antineoplastic Phase 2
34 Antiviral Agents Phase 2
35
Celecoxib Approved, Investigational Phase 1 169590-42-5 2662
36 Antibodies Phase 1
37 Antibodies, Monoclonal Phase 1
38 Immunoglobulins Phase 1
39 Analgesics Phase 1
40 Analgesics, Non-Narcotic Phase 1
41 Anti-Inflammatory Agents Phase 1
42 Anti-Inflammatory Agents, Non-Steroidal Phase 1
43 Antirheumatic Agents Phase 1
44 Cyclooxygenase 2 Inhibitors Phase 1
45 Cyclooxygenase Inhibitors Phase 1
46 Peripheral Nervous System Agents Phase 1
47 Liver Extracts Early Phase 1
48 Cola Nutraceutical Early Phase 1

Interventional clinical trials:

(show all 34)

# Name Status NCT ID Phase Drugs
1 Observation, Radiation Therapy, Combination Chemotherapy, and/or Surgery in Treating Young Patients With Soft Tissue Sarcoma Completed NCT00346164 Phase 3 doxorubicin hydrochloride;ifosfamide
2 Surgery With or Without Combination Chemotherapy in Treating Patients With Lung Metastases From Soft Tissue Sarcoma Completed NCT00002764 Phase 3 doxorubicin hydrochloride;ifosfamide
3 Ifosfamide or Doxorubicin in Treating Patients With Advanced or Metastatic Soft Tissue Sarcoma Completed NCT00003212 Phase 3 doxorubicin hydrochloride;ifosfamide
4 Combination Chemotherapy With or Without Hyperthermia Therapy in Treating Patients With Soft Tissue Sarcoma Completed NCT00003052 Phase 3 doxorubicin hydrochloride;etoposide;ifosfamide
5 Surgery With or Without Chemotherapy in Treating Patients With Soft Tissue Sarcoma Completed NCT00002641 Phase 3 doxorubicin hydrochloride;ifosfamide;isolated perfusion
6 Doxorubicin With or Without Ifosfamide and Pegfilgrastim in Treating Patients With Locally Advanced or Metastatic Soft Tissue Sarcoma Completed NCT00061984 Phase 3 doxorubicin hydrochloride;ifosfamide
7 Surgery With or Without Radiation Therapy in Treating Patients With Primary Soft Tissue Sarcoma of the Retroperitoneum or Pelvis Completed NCT00091351 Phase 3
8 Radiation Therapy With or Without Combination Chemotherapy or Pazopanib Hydrochloride Before Surgery in Treating Patients With Newly Diagnosed Non-rhabdomyosarcoma Soft Tissue Sarcomas That Can Be Removed by Surgery Recruiting NCT02180867 Phase 2, Phase 3 Doxorubicin Hydrochloride;Ifosfamide;Pazopanib Hydrochloride
9 Surgery With or Without Radiation Therapy in Untreated Nonmetastatic Retroperitoneal Sarcoma Recruiting NCT01344018 Phase 3
10 Randomised Trial of Volume of Post-operative Radiotherapy Given to Adult Patients With eXtremity Soft Tissue Sarcoma Active, not recruiting NCT00423618 Phase 3
11 Doxorubicin Hydrochloride or Trabectedin in Treating Patients With Previously Untreated Advanced or Metastatic Soft Tissue Sarcoma Terminated NCT01189253 Phase 2, Phase 3 doxorubicin hydrochloride;trabectedin
12 Temozolomide in Treating Patients With Advanced Soft Tissue Sarcoma Unknown status NCT00003718 Phase 2 temozolomide
13 Brostallicin or Doxorubicin as First-Line Therapy in Treating Patients With Relapsed, Refractory, or Metastatic Soft Tissue Sarcoma Unknown status NCT00410462 Phase 2 brostallicin;doxorubicin hydrochloride
14 Imatinib Mesylate in Treating Patients With Locally Recurrent or Metastatic Dermatofibrosarcoma Protuberans Completed NCT00084630 Phase 2 imatinib mesylate
15 Imatinib Mesylate in Treating Patients With Locally Advanced or Metastatic Dermatofibrosarcoma Protuberans or Giant Cell Fibroblastoma Completed NCT00085475 Phase 2 imatinib mesylate
16 AZD0530 in Treating Patients With Recurrent Locally Advanced or Metastatic Soft Tissue Sarcoma Completed NCT00659360 Phase 2 saracatinib
17 Vismodegib and Gamma-Secretase/Notch Signalling Pathway Inhibitor RO4929097 in Treating Patients With Advanced or Metastatic Sarcoma Completed NCT01154452 Phase 1, Phase 2 Gamma-Secretase Inhibitor RO4929097;Vismodegib
18 Depsipeptide (Romidepsin) in Treating Patients With Metastatic or Unresectable Soft Tissue Sarcoma Completed NCT00112463 Phase 2 romidepsin
19 Ecteinascidin 743 in Treating Patients With Advanced Soft Tissue Sarcoma Completed NCT00003939 Phase 2 trabectedin
20 STI571 in Treating Patients With Recurrent or Refractory Soft Tissue Sarcoma Completed NCT00006357 Phase 1, Phase 2 imatinib mesylate
21 Brostallicin in Treating Patients With Locally Advanced or Metastatic Soft Tissue Sarcoma Completed NCT00041249 Phase 2 brostallicin
22 Exatecan Mesylate in Treating Patients With Advanced Soft Tissue Sarcoma Completed NCT00041236 Phase 2 exatecan mesylate
23 Perifosine in Treating Patients With Metastatic or Locally Advanced Soft Tissue Sarcoma Completed NCT00053794 Phase 2 perifosine
24 BI 2536 in Treating Patients With Recurrent or Metastatic Solid Tumors Completed NCT00526149 Phase 2 BI 2536
25 Sunitinib in Treating Patients With Metastatic, Locally Advanced, or Locally Recurrent Sarcomas Completed NCT00474994 Phase 2 sunitinib malate
26 Soblidotin in Treating Patients With Advanced or Metastatic Soft Tissue Sarcoma Completed NCT00064220 Phase 2 soblidotin
27 Gemcitabine Hydrochloride With or Without Pazopanib Hydrochloride in Treating Patients With Refractory Soft Tissue Sarcoma Recruiting NCT01532687 Phase 2 Gemcitabine Hydrochloride;Pazopanib Hydrochloride
28 S9624 Ifosfamide in Treating Patients With Meningeal Tumors Terminated NCT00003292 Phase 2 ifosfamide
29 Intensity-Modulated Radiation Therapy in Treating Patients Undergoing Surgery for Stage IB, Stage II, or Stage III Soft Tissue Sarcoma Terminated NCT00740597 Phase 2
30 Cixutumumab and Doxorubicin Hydrochloride in Treating Patients With Unresectable, Locally Advanced, or Metastatic Soft Tissue Sarcoma Completed NCT00720174 Phase 1 Doxorubicin Hydrochloride
31 Liposomal Doxorubicin Plus Ifosfamide in Treating Patients With Advanced or Metastatic Soft Tissue Sarcoma Completed NCT00030784 Phase 1 ifosfamide;pegylated liposomal doxorubicin hydrochloride
32 Celecoxib and Radiation Therapy in Treating Patients With Stage II or Stage III Soft Tissue Sarcoma of the Arm, Hand, Leg, or Foot That Has Been Removed by Surgery Completed NCT00450736 Phase 1 celecoxib
33 Tissue Sample Collection From Patients With Soft Tissue Sarcoma of the Arms, Hands, Legs, or Feet Treated on Clinial Trial CRUK-VORTEX Unknown status NCT00900211
34 Tumor Necrosis Factor in Patients Undergoing Surgery for Primary Cancer or Metastatic Cancer Completed NCT00436410 Early Phase 1

Search NIH Clinical Center for Adult Fibrosarcoma

Genetic Tests for Adult Fibrosarcoma

Anatomical Context for Adult Fibrosarcoma

MalaCards organs/tissues related to Adult Fibrosarcoma:

38
Lung, Liver

Publications for Adult Fibrosarcoma

Articles related to Adult Fibrosarcoma:

# Title Authors Year
1
Adult fibrosarcoma: surgical management in developing countries. ( 25528208 )
2015
2
Adult fibrosarcoma of the wrist: a case report. ( 22689150 )
2012
3
Gains of 12q are the most frequent genomic imbalances in adult fibrosarcoma and are correlated with a poor outcome. ( 11921284 )
2002
4
Expression of COL1A1-PDGFB fusion transcripts in superficial adult fibrosarcoma suggests a close relationship to dermatofibrosarcoma protuberans. ( 11329146 )
2001

Variations for Adult Fibrosarcoma

Expression for Adult Fibrosarcoma

Search GEO for disease gene expression data for Adult Fibrosarcoma.

Pathways for Adult Fibrosarcoma

Pathways related to Adult Fibrosarcoma according to GeneCards Suite gene sharing:

# Super pathways Score Top Affiliating Genes
1 10.94 HRAS PDGFB
2 10.82 HRAS PDGFB
3 10.78 MYOD1 MYOG PDGFB
4
Show member pathways
10.62 FDPS HRAS
5 10.1 COL1A1 PDGFB

GO Terms for Adult Fibrosarcoma

Biological processes related to Adult Fibrosarcoma according to GeneCards Suite gene sharing:

(show all 18)
# Name GO ID Score Top Affiliating Genes
1 positive regulation of transcription by RNA polymerase II GO:0045944 9.93 ETV6 HRAS MYOD1 MYOG WT1
2 positive regulation of transcription, DNA-templated GO:0045893 9.72 COL1A1 MYOD1 MYOG PDGFB WT1
3 cellular response to tumor necrosis factor GO:0071356 9.61 COL1A1 MYOD1 MYOG
4 positive regulation of DNA replication GO:0045740 9.58 HRAS PDGFB
5 cellular response to estradiol stimulus GO:0071392 9.57 MYOD1 MYOG
6 activation of protein kinase B activity GO:0032148 9.56 NTRK3 PDGFB
7 skeletal muscle fiber development GO:0048741 9.55 MYOD1 MYOG
8 positive regulation of muscle cell differentiation GO:0051149 9.52 MYOD1 MYOG
9 positive regulation of myoblast differentiation GO:0045663 9.51 MYOD1 MYOG
10 myoblast differentiation GO:0045445 9.49 MYOD1 MYOG
11 positive regulation of actin cytoskeleton reorganization GO:2000251 9.48 HRAS NTRK3
12 positive regulation of myoblast fusion GO:1901741 9.46 MYOD1 MYOG
13 cellular response to retinoic acid GO:0071300 9.43 COL1A1 MYOG NTRK3
14 myotube differentiation GO:0014902 9.4 MYOD1 MYOG
15 positive regulation of skeletal muscle fiber development GO:0048743 9.37 MYOD1 MYOG
16 heart development GO:0007507 9.26 MB NTRK3 PDGFB WT1
17 muscle cell fate commitment GO:0042693 9.16 MYOD1 MYOG
18 positive regulation of cell migration GO:0030335 8.92 COL1A1 HRAS NTRK3 PDGFB

Molecular functions related to Adult Fibrosarcoma according to GeneCards Suite gene sharing:

# Name GO ID Score Top Affiliating Genes
1 RNA polymerase II regulatory region sequence-specific DNA binding GO:0000977 9.33 ETV6 MYOD1 MYOG
2 E-box binding GO:0070888 9.26 MYOD1 MYOG
3 sequence-specific DNA binding GO:0043565 9.26 ETV6 MYOD1 MYOG WT1
4 platelet-derived growth factor binding GO:0048407 8.62 COL1A1 PDGFB

Sources for Adult Fibrosarcoma

3 CDC
7 CNVD
9 Cosmic
10 dbSNP
11 DGIdb
16 ExPASy
18 FMA
27 GO
28 GTR
29 HGMD
30 HMDB
31 HPO
32 ICD10
33 ICD10 via Orphanet
34 ICD9CM
35 IUPHAR
36 KEGG
37 LifeMap
39 MedGen
41 MeSH
42 MESH via Orphanet
43 MGI
45 NCI
46 NCIt
47 NDF-RT
50 NINDS
51 Novoseek
53 OMIM
54 OMIM via Orphanet
58 PubMed
60 QIAGEN
65 SNOMED-CT via HPO
66 SNOMED-CT via Orphanet
67 TGDB
68 Tocris
69 UMLS
70 UMLS via Orphanet
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