MCID: ADL019
MIFTS: 33

Adult Fibrosarcoma

Categories: Cancer diseases, Rare diseases

Aliases & Classifications for Adult Fibrosarcoma

MalaCards integrated aliases for Adult Fibrosarcoma:

Name: Adult Fibrosarcoma 12 14 69

Classifications:



External Ids:

Disease Ontology 12 DOID:3516
NCIt 47 C7809
UMLS 69 C0278595

Summaries for Adult Fibrosarcoma

MalaCards based summary : Adult Fibrosarcoma is related to ceroid lipofuscinosis, neuronal, 9 and intracystic papillary adenoma. An important gene associated with Adult Fibrosarcoma is NTRK3 (Neurotrophic Receptor Tyrosine Kinase 3), and among its related pathways/superpathways are G-protein signaling_H-RAS regulation pathway and Mesenchymal Stem Cell Differentiation Pathways and Lineage-specific Markers. The drugs Doxorubicin and Ifosfamide have been mentioned in the context of this disorder. Affiliated tissues include lung and liver, and related phenotypes are cardiovascular system and growth/size/body region

Related Diseases for Adult Fibrosarcoma

Diseases in the Fibrosarcoma family:

Adult Fibrosarcoma Congenital Fibrosarcoma

Diseases related to Adult Fibrosarcoma via text searches within MalaCards or GeneCards Suite gene sharing:

(show top 50) (show all 59)
id Related Disease Score Top Affiliating Genes
1 ceroid lipofuscinosis, neuronal, 9 10.7 ETV6 NTRK3
2 intracystic papillary adenoma 10.7 ETV6 NTRK3
3 cerebral arterial disease 10.7 ETV6 NTRK3
4 maxillary sinus schneiderian papilloma 10.6 ETV6 NTRK3
5 follicular infundibulum tumor 10.6 ETV6 NTRK3
6 ring chromosome 8 10.6 COL1A1 PDGFB
7 spleen cancer 10.6 MB MYOD1
8 benallegue lacete syndrome 10.6 COL1A1 PDGFB
9 transitional cell carcinoma 10.5 MB MYOD1
10 mucinous ovarian cystadenoma 10.5 MB MYOD1
11 acromegaly 10.5 COL1A1 PDGFB
12 embryonal extrahepatic bile duct rhabdomyosarcoma 10.5 MB MYOD1
13 klatskin's tumor 10.5 ETV6 NTRK3
14 endodermal sinus tumor 10.4 MB MYOD1
15 glomerulonephritis 10.4 MB MYOD1
16 median neuropathy 10.4 MB PDGFB
17 lung benign neoplasm 10.4 MB WT1
18 immunodeficiency 39 10.2 COL1A1 FDPS
19 proliferative glomerulonephritis 10.2 ETV6 NTRK3 WT1
20 localized osteosarcoma 10.2 HRAS MYOD1
21 leydig cell tumor 10.2 COL1A1 PDGFB
22 juxtacortical osteosarcoma 10.2 PDGFB WT1
23 fibrous meningioma 10.2 HRAS WT1
24 plantar fasciitis 10.1 MB WT1
25 testis rhabdomyosarcoma 10.1 MYOD1 MYOG
26 primary pulmonary lymphoma 10.1 MYOD1 MYOG
27 cerebrum cancer 10.1 MB MYOD1 WT1
28 granular cell leiomyosarcoma 10.1 MYOD1 MYOG
29 colon leiomyosarcoma 10.1 MYOD1 MYOG
30 hypersensitivity reaction type iii disease 10.1 HRAS MB
31 phagocyte bactericidal dysfunction 10.1 MB MYOG
32 non-distal trisomy 10q 10.1 ETV6 HRAS NTRK3
33 cervical wilms' tumor 10.0 HRAS WT1
34 vagina, absence of 10.0 MB WT1
35 enamel hypoplasia cataract hydrocephaly 9.9 MYOD1 MYOG
36 dyserythropoietic anemia and thrombocytopenia 9.9 HRAS WT1
37 fibrosarcoma 9.9
38 gestational choriocarcinoma 9.9 COL1A1 NTRK3 PDGFB WT1
39 peroxisome biogenesis disorder 7a 9.8 ETV6 HRAS WT1
40 hemolytic anemia 9.8 ETV6 HRAS WT1
41 bile duct sarcoma 9.8 MB MYOD1 MYOG
42 nasal cavity disease 9.8 HRAS WT1
43 melanotic medulloblastoma 9.8 MB MYOD1 MYOG
44 central nervous system rhabdomyosarcoma 9.8 MB MYOD1 MYOG
45 cutaneous liposarcoma 9.7 MYOD1 MYOG WT1
46 nodular tenosynovitis 9.7 MYOD1 MYOG WT1
47 dextrocardia with situs inversus 9.7 MYOD1 MYOG WT1
48 prostate rhabdomyosarcoma 9.6 MB MYOD1 MYOG
49 pulmonary immaturity 9.6 MYOD1 MYOG
50 hyperbiliverdinemia 9.6 MYOD1 MYOG WT1

Graphical network of the top 20 diseases related to Adult Fibrosarcoma:



Diseases related to Adult Fibrosarcoma

Symptoms & Phenotypes for Adult Fibrosarcoma

MGI Mouse Phenotypes related to Adult Fibrosarcoma:

44
id Description MGI Source Accession Score Top Affiliating Genes
1 cardiovascular system MP:0005385 10.06 COL1A1 ETV6 HRAS MB MYOD1 NTRK3
2 growth/size/body region MP:0005378 10.06 COL1A1 ETV6 HRAS MB MYOD1 MYOG
3 mortality/aging MP:0010768 10.02 COL1A1 ETV6 HRAS MB MYOD1 MYOG
4 embryo MP:0005380 9.91 COL1A1 ETV6 MB MYOG PDGFB WT1
5 muscle MP:0005369 9.8 MB MYOD1 MYOG PDGFB WT1 COL1A1
6 no phenotypic analysis MP:0003012 9.76 COL1A1 ETV6 HRAS MYOD1 MYOG NTRK3
7 neoplasm MP:0002006 9.65 COL1A1 ETV6 HRAS MYOD1 WT1
8 normal MP:0002873 9.5 COL1A1 ETV6 HRAS MYOD1 MYOG NTRK3
9 respiratory system MP:0005388 9.23 MYOG NTRK3 PDGFB WT1 COL1A1 HRAS

Drugs & Therapeutics for Adult Fibrosarcoma

Drugs for Adult Fibrosarcoma (from DrugBank, HMDB, Dgidb, PharmGKB, IUPHAR, NovoSeek, BitterDB):

(show all 49)
id Name Status Phase Clinical Trials Cas Number PubChem Id
1
Doxorubicin Approved, Investigational Phase 3,Phase 2,Phase 1 23214-92-8 31703
2
Ifosfamide Approved Phase 3,Phase 2,Phase 1 3778-73-2 3690
3
Mechlorethamine Approved Phase 3,Phase 2,Phase 1 51-75-2 4033
4
Etoposide Approved Phase 3 33419-42-0 36462
5
Lenograstim Approved Phase 3 135968-09-1
6
Trabectedin Approved, Investigational Phase 2, Phase 3 114899-77-3 108150
7
Cyclophosphamide Approved, Investigational Phase 2, Phase 3 50-18-0, 6055-19-2 2907
8
Doxil Approved June 1999 Phase 3,Phase 2,Phase 1 31703
9 Alkylating Agents Phase 3,Phase 2,Phase 1
10 Anti-Bacterial Agents Phase 3,Phase 2,Phase 1
11 Antibiotics, Antitubercular Phase 3,Phase 2,Phase 1
12 Topoisomerase Inhibitors Phase 3,Phase 2,Phase 1
13 Isophosphamide mustard Phase 3,Phase 2,Phase 1
14 Antineoplastic Agents, Phytogenic Phase 3,Phase 2
15 Etoposide phosphate Phase 3
16
Dacarbazine Approved, Investigational Phase 2 4342-03-4 5351166
17
Temozolomide Approved, Investigational Phase 2 85622-93-1 5394
18
Romidepsin Approved, Investigational Phase 2 128517-07-7 5352062
19
Sunitinib Approved, Investigational Phase 2 341031-54-7, 557795-19-4 5329102
20
Gemcitabine Approved Phase 2 95058-81-4 60750
21
Saracatinib Investigational Phase 2 379231-04-6
22
Camptothecin Experimental Phase 2 7689-03-4
23 Exatecan Investigational Phase 2 171335-80-1
24 Soblidotin Investigational Phase 2 149606-27-9
25 Imatinib Mesylate Phase 2,Phase 1 123596
26 Protein Kinase Inhibitors Phase 2,Phase 1
27 topoisomerase I inhibitors Phase 2
28 Angiogenesis Inhibitors Phase 2
29 Angiogenesis Modulating Agents Phase 2
30 Immunosuppressive Agents Phase 2
31 Anti-Infective Agents Phase 2
32 Antimetabolites Phase 2
33 Antimetabolites, Antineoplastic Phase 2
34 Antiviral Agents Phase 2
35 tyrosine Nutraceutical Phase 2
36
Celecoxib Approved, Investigational Phase 1 169590-42-5 2662
37 Antibodies Phase 1
38 Antibodies, Monoclonal Phase 1
39 Immunoglobulins Phase 1
40 Analgesics Phase 1
41 Analgesics, Non-Narcotic Phase 1
42 Anti-Inflammatory Agents Phase 1
43 Anti-Inflammatory Agents, Non-Steroidal Phase 1
44 Antirheumatic Agents Phase 1
45 Cyclooxygenase 2 Inhibitors Phase 1
46 Cyclooxygenase Inhibitors Phase 1
47 Peripheral Nervous System Agents Phase 1
48 Liver Extracts Early Phase 1
49 Cola Nutraceutical Early Phase 1

Interventional clinical trials:

(show all 35)

id Name Status NCT ID Phase Drugs
1 Observation, Radiation Therapy, Combination Chemotherapy, and/or Surgery in Treating Young Patients With Soft Tissue Sarcoma Completed NCT00346164 Phase 3 doxorubicin hydrochloride;ifosfamide
2 Combination Chemotherapy With or Without Hyperthermia Therapy in Treating Patients With Soft Tissue Sarcoma Completed NCT00003052 Phase 3 doxorubicin hydrochloride;etoposide;ifosfamide
3 Ifosfamide or Doxorubicin in Treating Patients With Advanced or Metastatic Soft Tissue Sarcoma Completed NCT00003212 Phase 3 doxorubicin hydrochloride;ifosfamide
4 Surgery With or Without Chemotherapy in Treating Patients With Soft Tissue Sarcoma Completed NCT00002641 Phase 3 doxorubicin hydrochloride;ifosfamide;isolated perfusion
5 Surgery With or Without Combination Chemotherapy in Treating Patients With Lung Metastases From Soft Tissue Sarcoma Completed NCT00002764 Phase 3 doxorubicin hydrochloride;ifosfamide
6 Doxorubicin With or Without Ifosfamide and Pegfilgrastim in Treating Patients With Locally Advanced or Metastatic Soft Tissue Sarcoma Completed NCT00061984 Phase 3 doxorubicin hydrochloride;ifosfamide
7 Surgery With or Without Radiation Therapy in Treating Patients With Primary Soft Tissue Sarcoma of the Retroperitoneum or Pelvis Completed NCT00091351 Phase 3
8 Radiation Therapy With or Without Combination Chemotherapy or Pazopanib Hydrochloride Before Surgery in Treating Patients With Newly Diagnosed Non-rhabdomyosarcoma Soft Tissue Sarcomas That Can Be Removed by Surgery Recruiting NCT02180867 Phase 2, Phase 3 Doxorubicin Hydrochloride;Ifosfamide;Pazopanib Hydrochloride
9 Surgery With or Without Radiation Therapy in Untreated Nonmetastatic Retroperitoneal Sarcoma Recruiting NCT01344018 Phase 3
10 Randomised Trial of Volume of Post-operative Radiotherapy Given to Adult Patients With eXtremity Soft Tissue Sarcoma Active, not recruiting NCT00423618 Phase 3
11 Doxorubicin Hydrochloride or Trabectedin in Treating Patients With Previously Untreated Advanced or Metastatic Soft Tissue Sarcoma Terminated NCT01189253 Phase 2, Phase 3 doxorubicin hydrochloride;trabectedin
12 Temozolomide in Treating Patients With Advanced Soft Tissue Sarcoma Unknown status NCT00003718 Phase 2 temozolomide
13 Brostallicin or Doxorubicin as First-Line Therapy in Treating Patients With Relapsed, Refractory, or Metastatic Soft Tissue Sarcoma Unknown status NCT00410462 Phase 2 brostallicin;doxorubicin hydrochloride
14 Imatinib Mesylate in Treating Patients With Locally Recurrent or Metastatic Dermatofibrosarcoma Protuberans Completed NCT00084630 Phase 2 imatinib mesylate
15 Imatinib Mesylate in Treating Patients With Locally Advanced or Metastatic Dermatofibrosarcoma Protuberans or Giant Cell Fibroblastoma Completed NCT00085475 Phase 2 imatinib mesylate
16 AZD0530 in Treating Patients With Recurrent Locally Advanced or Metastatic Soft Tissue Sarcoma Completed NCT00659360 Phase 2 saracatinib
17 Depsipeptide (Romidepsin) in Treating Patients With Metastatic or Unresectable Soft Tissue Sarcoma Completed NCT00112463 Phase 2 romidepsin
18 Vismodegib and Gamma-Secretase/Notch Signalling Pathway Inhibitor RO4929097 in Treating Patients With Advanced or Metastatic Sarcoma Completed NCT01154452 Phase 1, Phase 2 Gamma-Secretase Inhibitor RO4929097;Vismodegib
19 Ecteinascidin 743 in Treating Patients With Advanced Soft Tissue Sarcoma Completed NCT00003939 Phase 2 trabectedin
20 Exatecan Mesylate in Treating Patients With Advanced Soft Tissue Sarcoma Completed NCT00041236 Phase 2 exatecan mesylate
21 Brostallicin in Treating Patients With Locally Advanced or Metastatic Soft Tissue Sarcoma Completed NCT00041249 Phase 2 brostallicin
22 STI571 in Treating Patients With Recurrent or Refractory Soft Tissue Sarcoma Completed NCT00006357 Phase 1, Phase 2 imatinib mesylate
23 Perifosine in Treating Patients With Metastatic or Locally Advanced Soft Tissue Sarcoma Completed NCT00053794 Phase 2 perifosine
24 Sunitinib in Treating Patients With Metastatic, Locally Advanced, or Locally Recurrent Sarcomas Completed NCT00474994 Phase 2 sunitinib malate
25 Soblidotin in Treating Patients With Advanced or Metastatic Soft Tissue Sarcoma Completed NCT00064220 Phase 2 soblidotin
26 BI 2536 in Treating Patients With Recurrent or Metastatic Solid Tumors Completed NCT00526149 Phase 2 BI 2536
27 Phase II Study of Sunitinib Malate for Metastatic and/or Surgically Unresectable Soft Tissue Sarcoma Completed NCT00400569 Phase 2 Sunitinib Malate (SU011248)
28 Gemcitabine Hydrochloride With or Without Pazopanib Hydrochloride in Treating Patients With Refractory Soft Tissue Sarcoma Recruiting NCT01532687 Phase 2 Gemcitabine Hydrochloride;Pazopanib Hydrochloride
29 S9624 Ifosfamide in Treating Patients With Meningeal Tumors Terminated NCT00003292 Phase 2 ifosfamide
30 Intensity-Modulated Radiation Therapy in Treating Patients Undergoing Surgery for Stage IB, Stage II, or Stage III Soft Tissue Sarcoma Terminated NCT00740597 Phase 2
31 Cixutumumab and Doxorubicin Hydrochloride in Treating Patients With Unresectable, Locally Advanced, or Metastatic Soft Tissue Sarcoma Completed NCT00720174 Phase 1 Doxorubicin Hydrochloride
32 Liposomal Doxorubicin Plus Ifosfamide in Treating Patients With Advanced or Metastatic Soft Tissue Sarcoma Completed NCT00030784 Phase 1 ifosfamide;pegylated liposomal doxorubicin hydrochloride
33 Celecoxib and Radiation Therapy in Treating Patients With Stage II or Stage III Soft Tissue Sarcoma of the Arm, Hand, Leg, or Foot That Has Been Removed by Surgery Completed NCT00450736 Phase 1 celecoxib
34 Tissue Sample Collection From Patients With Soft Tissue Sarcoma of the Arms, Hands, Legs, or Feet Treated on Clinial Trial CRUK-VORTEX Unknown status NCT00900211
35 Tumor Necrosis Factor in Patients Undergoing Surgery for Primary Cancer or Metastatic Cancer Completed NCT00436410 Early Phase 1

Search NIH Clinical Center for Adult Fibrosarcoma

Genetic Tests for Adult Fibrosarcoma

Anatomical Context for Adult Fibrosarcoma

MalaCards organs/tissues related to Adult Fibrosarcoma:

39
Lung, Liver

Publications for Adult Fibrosarcoma

Articles related to Adult Fibrosarcoma:

id Title Authors Year
1
Adult fibrosarcoma: surgical management in developing countries. ( 25528208 )
2015
2
Adult fibrosarcoma of the wrist: a case report. ( 22689150 )
2012
3
Gains of 12q are the most frequent genomic imbalances in adult fibrosarcoma and are correlated with a poor outcome. ( 11921284 )
2002
4
Expression of COL1A1-PDGFB fusion transcripts in superficial adult fibrosarcoma suggests a close relationship to dermatofibrosarcoma protuberans. ( 11329146 )
2001

Variations for Adult Fibrosarcoma

Expression for Adult Fibrosarcoma

Search GEO for disease gene expression data for Adult Fibrosarcoma.

Pathways for Adult Fibrosarcoma

Pathways related to Adult Fibrosarcoma according to GeneCards Suite gene sharing:

id Super pathways Score Top Affiliating Genes
1 10.82 HRAS PDGFB
2 10.78 MYOD1 MYOG PDGFB
3
Show member pathways
10.62 FDPS HRAS
4 10.1 COL1A1 PDGFB

GO Terms for Adult Fibrosarcoma

Biological processes related to Adult Fibrosarcoma according to GeneCards Suite gene sharing:

(show all 17)
id Name GO ID Score Top Affiliating Genes
1 positive regulation of transcription from RNA polymerase II promoter GO:0045944 9.92 ETV6 HRAS MYOD1 MYOG WT1
2 positive regulation of transcription, DNA-templated GO:0045893 9.72 COL1A1 MYOD1 MYOG PDGFB WT1
3 positive regulation of DNA replication GO:0045740 9.57 HRAS PDGFB
4 cellular response to estradiol stimulus GO:0071392 9.56 MYOD1 MYOG
5 skeletal muscle fiber development GO:0048741 9.55 MYOD1 MYOG
6 activation of protein kinase B activity GO:0032148 9.54 NTRK3 PDGFB
7 positive regulation of muscle cell differentiation GO:0051149 9.51 MYOD1 MYOG
8 myoblast differentiation GO:0045445 9.49 MYOD1 MYOG
9 positive regulation of myoblast differentiation GO:0045663 9.48 MYOD1 MYOG
10 positive regulation of myoblast fusion GO:1901741 9.46 MYOD1 MYOG
11 positive regulation of actin cytoskeleton reorganization GO:2000251 9.43 HRAS NTRK3
12 cellular response to retinoic acid GO:0071300 9.43 COL1A1 MYOG NTRK3
13 myotube differentiation GO:0014902 9.4 MYOD1 MYOG
14 positive regulation of skeletal muscle fiber development GO:0048743 9.37 MYOD1 MYOG
15 heart development GO:0007507 9.26 MB NTRK3 PDGFB WT1
16 muscle cell fate commitment GO:0042693 9.16 MYOD1 MYOG
17 positive regulation of cell migration GO:0030335 8.92 COL1A1 HRAS NTRK3 PDGFB

Molecular functions related to Adult Fibrosarcoma according to GeneCards Suite gene sharing:

id Name GO ID Score Top Affiliating Genes
1 RNA polymerase II regulatory region sequence-specific DNA binding GO:0000977 9.43 ETV6 MYOD1 MYOG
2 sequence-specific DNA binding GO:0043565 9.26 ETV6 MYOD1 MYOG WT1
3 E-box binding GO:0070888 9.16 MYOD1 MYOG
4 platelet-derived growth factor binding GO:0048407 8.62 COL1A1 PDGFB

Sources for Adult Fibrosarcoma

3 CDC
7 CNVD
9 Cosmic
10 dbSNP
11 DGIdb
16 ExPASy
18 FMA
28 GO
29 GTR
30 HGMD
31 HMDB
32 HPO
33 ICD10
34 ICD10 via Orphanet
35 ICD9CM
36 IUPHAR
37 KEGG
38 LifeMap
40 MedGen
42 MeSH
43 MESH via Orphanet
44 MGI
46 NCI
47 NCIt
48 NDF-RT
51 NINDS
52 Novoseek
54 OMIM
55 OMIM via Orphanet
59 PubMed
60 QIAGEN
65 SNOMED-CT via HPO
66 SNOMED-CT via Orphanet
67 TGDB
68 Tocris
69 UMLS
70 UMLS via Orphanet
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