MCID: ADL023
MIFTS: 53

Adult Medulloblastoma

Categories: Rare diseases, Neuronal diseases, Genetic diseases, Cancer diseases

Aliases & Classifications for Adult Medulloblastoma

MalaCards integrated aliases for Adult Medulloblastoma:

Name: Adult Medulloblastoma 12 14
Adult Brain Medulloblastoma 12 69
Medulloblastoma, Adult 69

Classifications:



External Ids:

Disease Ontology 12 DOID:3864
MeSH 41 D008527
NCIt 46 C4011 C9373

Summaries for Adult Medulloblastoma

MalaCards based summary : Adult Medulloblastoma, also known as adult brain medulloblastoma, is related to gangliocytoma and meningioma, familial, and has symptoms including gait ataxia, vomiting and headache. An important gene associated with Adult Medulloblastoma is SHH (Sonic Hedgehog), and among its related pathways/superpathways are Pathways in cancer and Neuroscience. The drugs Fentanyl and Donepezil have been mentioned in the context of this disorder. Affiliated tissues include brain, bone and bone marrow, and related phenotypes are Decreased viability in esophageal squamous lineage and behavior/neurological

Related Diseases for Adult Medulloblastoma

Diseases in the Medulloblastoma family:

Adult Medulloblastoma

Diseases related to Adult Medulloblastoma via text searches within MalaCards or GeneCards Suite gene sharing:

(show top 50) (show all 153)
# Related Disease Score Top Affiliating Genes
1 gangliocytoma 29.6 GFAP SYP
2 meningioma, familial 28.9 GFAP PTCH1 SUFU SYP TP53
3 medulloblastoma 28.6 ENO2 GFAP GLI1 MYCN PTCH1 SHH
4 microform holoprosencephaly 10.4 PTCH1 SHH SUFU
5 septopreoptic holoprosencephaly 10.4 PTCH1 SHH
6 calcifying epithelial odontogenic tumor 10.4 PTCH1 TP53
7 intracranial chondrosarcoma 10.4 IDH1 TP53
8 midline interhemispheric variant of holoprosencephaly 10.4 PTCH1 SHH
9 frontal convexity meningioma 10.4 GFAP TP53
10 cerebellar astrocytoma 10.4 IDH1 TP53
11 gliofibroma 10.4 GFAP TP53
12 ring chromosome 7 10.4 MDM2 TP53
13 cerebral convexity meningioma 10.4 GFAP TP53
14 protoplasmic astrocytoma 10.4 GFAP TP53
15 glioma susceptibility 1 10.4 IDH1 TP53
16 spinal cord glioma 10.3 TP53 TUBB3
17 actinic cheilitis 10.3 MDM2 TP53
18 pancreas adenocarcinoma 10.3 GLI1 SHH TP53
19 pancreatic ductal adenocarcinoma 10.3 GLI1 SHH TP53
20 lung combined type small cell carcinoma 10.2 GFAP SYP
21 basal cell nevus syndrome 10.2 GLI1 PTCH1 SHH SUFU
22 childhood medulloblastoma 10.2 MYCN PTCH1 SUFU
23 mixed glioma 10.2 GFAP IDH1 TP53
24 fibrillary astrocytoma 10.2 GFAP IDH1 TP53
25 gastric tubular adenocarcinoma 10.2 GLI1 SHH SYP
26 spinal cord astrocytoma 10.2 GFAP IDH1 TP53
27 intracranial cysts 10.2 ENO2 GFAP
28 periosteal osteogenic sarcoma 10.2 IDH1 MDM2 TP53
29 embryonal rhabdomyosarcoma 10.2 GLI1 MYCN PTCH1
30 primitive neuroectodermal tumor of the cervix uteri 10.1 ENO2 GFAP
31 pilomyxoid astrocytoma 10.1 GFAP SUFU SYP
32 inflammatory mfh 10.1 GFAP MDM2
33 melanotic medulloblastoma 10.1 ENO2 GFAP
34 rhabdoid meningioma 10.1 GFAP SYP
35 breast papillary carcinoma 10.1 IDH1 PTCH1 SYP
36 nodular medulloblastoma 10.1 GFAP GLI1 PTCH1 SUFU
37 grade iii astrocytoma 10.1 GFAP MDM2 TP53
38 extraventricular neurocytoma 10.1 GFAP IDH1 SYP
39 li-fraumeni syndrome 10.1 IDH1 MDM2 TP53
40 pleomorphic adenoma 10.1 GFAP MDM2 TP53
41 dysembryoplastic neuroepithelial tumor 10.1 GFAP IDH1 SYP
42 malignant sertoli cell tumor 10.1 ENO2 SYP
43 urinary bladder small cell neuroendocrine carcinoma 10.1 ENO2 SYP
44 angiocentric glioma 10.1 GFAP IDH1 SYP
45 cellular ependymoma 10.1 GFAP SYP TP53
46 adrenal neuroblastoma 10.1 ENO2 MYCN
47 sinonasal undifferentiated carcinoma 10.1 ENO2 SYP
48 cerebellopontine angle tumor 10.0 GFAP IDH1 SYP
49 papilloma of choroid plexus 10.0 GFAP SYP TP53
50 auditory system cancer 10.0 ENO2 SYP

Graphical network of the top 20 diseases related to Adult Medulloblastoma:



Diseases related to Adult Medulloblastoma

Symptoms & Phenotypes for Adult Medulloblastoma

UMLS symptoms related to Adult Medulloblastoma:


gait ataxia, vomiting, headache

GenomeRNAi Phenotypes related to Adult Medulloblastoma according to GeneCards Suite gene sharing:

25
# Description GenomeRNAi Source Accession Score Top Affiliating Genes
1 Decreased viability in esophageal squamous lineage GR00235-A 9.4 ATOH1 BRPF1 EIF5B GFAP GLI1 IDH1

MGI Mouse Phenotypes related to Adult Medulloblastoma:

43 (show all 16)
# Description MGI Source Accession Score Top Affiliating Genes
1 behavior/neurological MP:0005386 10.34 ENO2 GFAP ATOH1 BRPF1 GLI1 PTCH1
2 growth/size/body region MP:0005378 10.32 ENO2 GFAP GLI1 BRPF1 IDH1 PTCH1
3 cellular MP:0005384 10.31 ENO2 GFAP ATOH1 GLI1 BRPF1 KAT6A
4 mortality/aging MP:0010768 10.28 GFAP ATOH1 GLI1 BRPF1 IDH1 PTCH1
5 cardiovascular system MP:0005385 10.25 GFAP KAT6A MYCN PPP1R12A MDM2 SHH
6 digestive/alimentary MP:0005381 10.25 KAT6A GFAP ATOH1 GLI1 MYCN MDM2
7 nervous system MP:0003631 10.24 KAT6A GFAP ATOH1 GLI1 BRPF1 ENO2
8 homeostasis/metabolism MP:0005376 10.23 IDH1 GFAP ATOH1 BRPF1 MDM2 KAT6A
9 craniofacial MP:0005382 10.22 KAT6A GLI1 ENO2 MYCN MDM2 PTCH1
10 embryo MP:0005380 10.19 BRPF1 GLI1 PTCH1 KAT6A MYCN MDM2
11 limbs/digits/tail MP:0005371 10.09 KAT6A GLI1 PTCH1 MYCN MDM2 TP53
12 normal MP:0002873 10.03 KAT6A GFAP ATOH1 GLI1 BRPF1 MYCN
13 no phenotypic analysis MP:0003012 9.97 ATOH1 GLI1 PTCH1 MYCN MDM2 SHH
14 renal/urinary system MP:0005367 9.7 GLI1 MDM2 MYCN PPP1R12A SHH PTCH1
15 respiratory system MP:0005388 9.65 ENO2 ATOH1 GLI1 IDH1 MYCN PTCH1
16 skeleton MP:0005390 9.32 IDH1 BRPF1 PTCH1 KAT6A MYCN MDM2

Drugs & Therapeutics for Adult Medulloblastoma

Drugs for Adult Medulloblastoma (from DrugBank, HMDB, Dgidb, PharmGKB, IUPHAR, NovoSeek, BitterDB):

(show top 50) (show all 153)
# Name Status Phase Clinical Trials Cas Number PubChem Id
1
Fentanyl Approved, Illicit, Investigational, Vet_approved Phase 3 437-38-7 3345
2
Donepezil Approved Phase 3,Phase 2 120014-06-4 3152
3 Pancreatic Polypeptide Investigational Phase 3,Phase 1 59763-91-6
4 Adjuvants, Anesthesia Phase 3
5 Analgesics Phase 3,Phase 2
6 Analgesics, Opioid Phase 3
7 Anesthetics Phase 3
8 Anesthetics, General Phase 3
9 Anesthetics, Intravenous Phase 3
10 Central Nervous System Depressants Phase 3,Phase 2
11 Liver Extracts Phase 3,Phase 2,Phase 1
12 Narcotics Phase 3
13 Peripheral Nervous System Agents Phase 3,Phase 2
14 Cholinergic Agents Phase 3,Phase 2
15 Cholinesterase Inhibitors Phase 3,Phase 2
16 Neurotransmitter Agents Phase 3,Phase 2
17 Nootropic Agents Phase 3,Phase 2
18 Cola Nutraceutical Phase 3,Phase 1
19
Etoposide Approved Phase 2 33419-42-0 36462
20
Cisplatin Approved Phase 2 15663-27-1 2767 441203 84093
21
Cyclophosphamide Approved, Investigational Phase 2 50-18-0, 6055-19-2 2907
22
Lenograstim Approved, Investigational Phase 2,Phase 1 135968-09-1
23
Vincristine Approved, Investigational Phase 2,Phase 1 2068-78-2, 57-22-7 5978
24
Carmustine Approved, Investigational Phase 2,Phase 1 154-93-8 2578
25 Thiotepa Approved, Investigational Phase 2,Phase 1 52-24-4 5453
26
Methotrexate Approved Phase 2 1959-05-2, 59-05-2 126941
27
Iodine Approved, Investigational Phase 1, Phase 2 7553-56-2 807
28 Piracetam Approved, Investigational Phase 2 7491-74-9
29
Pregabalin Approved, Illicit, Investigational Phase 2 148553-50-8 5486971
30
Aldesleukin Approved Phase 2 110942-02-4, 85898-30-2
31
Paclitaxel Approved, Vet_approved Phase 2,Phase 1 33069-62-4 36314
32
Doxorubicin Approved, Investigational Phase 2 23214-92-8 31703
33
Tamoxifen Approved Phase 2 10540-29-1 2733526
34
Dacarbazine Approved, Investigational Phase 1, Phase 2 4342-03-4 5351166
35
Temozolomide Approved, Investigational Phase 1, Phase 2 85622-93-1 5394
36
Carboplatin Approved Phase 1, Phase 2 41575-94-4 10339178 38904 498142
37
Mannitol Approved, Investigational Phase 1, Phase 2 69-65-8 6251 453
38
Mechlorethamine Approved, Investigational Phase 1, Phase 2 51-75-2 4033
39
Melphalan Approved Phase 1, Phase 2 148-82-3 460612 4053
40
Acetaminophen Approved Phase 2 103-90-2 1983
41
Dexamethasone Approved, Investigational, Vet_approved Phase 2 50-02-2 5743
42
Diphenhydramine Approved, Investigational Phase 2 58-73-1, 147-24-0 3100
43
Promethazine Approved, Investigational Phase 2 60-87-7 4927
44
Folic Acid Approved, Nutraceutical, Vet_approved Phase 2 59-30-3 6037
45
leucovorin Approved, Nutraceutical Phase 2 58-05-9 143 6006
46
Citric Acid Approved, Nutraceutical, Vet_approved Phase 2 77-92-9 311
47 Etiracetam Investigational Phase 2 33996-58-6
48
Doxil Approved June 1999 Phase 2 31703
49 Antineoplastic Agents, Phytogenic Phase 2,Phase 1
50 Etoposide phosphate Phase 2

Interventional clinical trials:

(show all 49)

# Name Status NCT ID Phase Drugs
1 Fentanyl Sublingual Spray in Treating Patients With Breakthrough Cancer Pain Completed NCT00538850 Phase 3 Fentanyl sublingual spray;Placebo
2 Donepezil in Treating Patients Who Have Undergone Radiation Therapy for Brain Tumors Completed NCT00369785 Phase 3 donepezil hydrochloride;Placebo
3 Interest of a Dose Decrease for Radiotherapy Associated With Chemotherapy for Treatment of Standard Risk Adult Medulloblastomas Unknown status NCT01857453 Phase 2 carboplatine;Etoposide
4 Vismodegib in Treating Patients With Recurrent or Refractory Medulloblastoma Completed NCT00939484 Phase 2 Vismodegib
5 Combination Chemotherapy Plus Radiation Therapy in Treating Adult Patients With Brain Cancer Completed NCT00003309 Phase 2 cisplatin;cyclophosphamide;etoposide;vincristine sulfate
6 Chemotherapy Plus Peripheral Stem Cell Transplant in Treating Patients With Central Nervous System Cancer Completed NCT00007982 Phase 2 carmustine;cisplatin;cyclophosphamide;etoposide;thiotepa
7 Combination Chemotherapy Followed by Radiation Therapy in Treating Patients With Medulloblastoma, Supratentorial Primitive Neuroectodermal Tumor, or Ependymoma Completed NCT00006258 Phase 2 cisplatin;cyclophosphamide;etoposide;methotrexate;vincristine sulfate
8 Radiolabeled Monoclonal Antibody Therapy in Treating Patients With Primary Brain Tumors Completed NCT00003478 Phase 1, Phase 2
9 Radiolabeled Monoclonal Antibody Therapy in Treating Patients With Primary or Metastatic Brain Cancers Completed NCT00002752 Phase 1, Phase 2
10 Thiotepa Followed by Peripheral Stem Cell or Bone Marrow Transplant in Treating Patients With Malignant Glioma Completed NCT00008008 Phase 2 cyclophosphamide;thiotepa
11 Levetiracetam or Pregabalin in Treating Seizures in Patients Undergoing Chemotherapy and/or Radiation Therapy For Primary Brain Tumors Completed NCT00629889 Phase 2 levetiracetam;pregabalin
12 Radiolabeled Monoclonal Antibody Therapy in Treating Patients With Primary or Metastatic Brain Tumors Completed NCT00003461 Phase 1, Phase 2
13 Chemotherapy and Vaccine Therapy Followed by Bone Marrow or Peripheral Stem Cell Transplantation and Interleukin-2 in Treating Patients With Recurrent or Refractory Brain Cancer Completed NCT00014573 Phase 2 carmustine;cisplatin;cyclophosphamide;paclitaxel
14 Phase II Studies Of Donepezil And Ginkgo Biloba In Irradiated Brain Tumor Completed NCT00070161 Phase 2 donepezil hydrochloride
15 Combination Chemotherapy and Tamoxifen in Treating Patients With Solid Tumors Completed NCT00002608 Phase 2 cisplatin;doxorubicin hydrochloride;tamoxifen citrate
16 Study of Vismodegib in Combination With Temozolomide Versus Temozolomide Alone in Patients With Medulloblastomas With an Activation of the Sonic Hedgehog Pathway Recruiting NCT01601184 Phase 1, Phase 2 vismodegib;Temozolomide
17 Melphalan, Carboplatin, Mannitol, and Sodium Thiosulfate in Treating Patients With Recurrent or Progressive CNS Embryonal or Germ Cell Tumors Recruiting NCT00983398 Phase 1, Phase 2 Carboplatin;Mannitol;Melphalan;Sodium Thiosulfate
18 Plerixafor After Radiation Therapy and Temozolomide in Treating Patients With Newly Diagnosed High Grade Glioma Active, not recruiting NCT01977677 Phase 1, Phase 2 temozolomide;plerixafor
19 Iodine I 131 Monoclonal Antibody 3F8 in Treating Patients With Central Nervous System Cancer or Leptomeningeal Cancer Active, not recruiting NCT00445965 Phase 2
20 Photodynamic Therapy With Porfimer Sodium in Treating Patients With Refractory Brain Tumors Unknown status NCT00002647 Phase 1 verteporfin
21 Stereotactic Radiosurgery in Treating Patients With Brain Tumors Completed NCT00019578 Phase 1
22 RO4929097, Temozolomide, and Radiation Therapy in Treating Patients With Newly Diagnosed Malignant Glioma Completed NCT01119599 Phase 1 Gamma-Secretase Inhibitor RO4929097;Temozolomide
23 Combination Chemotherapy Followed by Peripheral Stem Cell Transplantation or Bone Marrow Transplantation in Treating Patients With Brain Cancer Completed NCT00025558 Phase 1 carboplatin;temozolomide;thiotepa
24 Combination Chemotherapy Plus Gene Therapy in Treating Patients With CNS Tumors Completed NCT00005796 Phase 1 lomustine;procarbazine hydrochloride;vincristine sulfate
25 Calcitriol Plus Carboplatin in Treating Patients With Advanced Solid Tumors Completed NCT00008086 Phase 1 carboplatin
26 Radiolabeled Monoclonal Antibody Therapy After Radiation Therapy in Treating Patients With Primary Brain Tumors Completed NCT00003484 Phase 1 carmustine;irinotecan hydrochloride
27 Bortezomib and Temozolomide in Treating Patients With Brain Tumors or Other Solid Tumors That Have Not Responded to Treatment Completed NCT00544284 Phase 1 bortezomib;temozolomide
28 Yttrium Y 90 SMT 487 in Treating Patients With Refractory or Recurrent Cancer Completed NCT00006368 Phase 1
29 Thalidomide and Docetaxel in Treating Patients With Advanced Cancer Completed NCT00049296 Phase 1 docetaxel;thalidomide
30 MS-275 in Treating Patients With Advanced Solid Tumors or Lymphoma Completed NCT00020579 Phase 1 entinostat
31 Carboxyamidotriazole and Paclitaxel in Treating Patients With Advanced Solid Tumors or Refractory Lymphomas Completed NCT00019019 Phase 1 carboxyamidotriazole;paclitaxel
32 Monoclonal Antibody Therapy in Treating Patients With Leptomeningeal Cancer Completed NCT00003022 Phase 1
33 Radiolabeled Monoclonal Antibody Therapy in Treating Patients With Refractory, Recurrent, or Advanced CNS or Leptomeningeal Cancer Recruiting NCT00089245 Phase 1
34 Positron Emission Tomography Using Fluorine F 18 EF5 to Find Oxygen in Tumor Cells of Patients Who Are Undergoing Surgery or Biopsy for Newly Diagnosed Brain Tumors Terminated NCT00110032 Phase 1 EF5
35 Melphalan With BBBD in Treating Patients With Brain Malignancies Terminated NCT00253721 Phase 1 Melphalan
36 Magnetic Resonance Imaging in Determining Extent of Cancer in Patients With Newly Diagnosed Glioma Completed NCT00005082
37 Study of Blood and Cheek Cell Samples From Patients With Glioma Completed NCT01009307
38 Study of Tissue Samples From Patients With Glioma or Other Brain Tumors Completed NCT00967200
39 Decision Making About Participating in Pharmacokinetic Studies in Patients Enrolled in a Phase I Treatment Clinical Trial Completed NCT00890435
40 A Feasibility, Dose-Escalation Study Using Intracerebral Microdialysis to Assess the Neuropharmacodynamics of Temsirolimus in Patients With Primary or Metastatic Brain Tumors Completed NCT00784914 temsirolimus
41 Changes in Semen or Sperm Caused by Temozolomide in Patients With Newly Diagnosed, Progressive, or Recurrent Primary Malignant Brain Tumors Completed NCT00499798
42 Stress Reduction Program in Patients With Malignant Brain Tumors and Their Family Caregivers Completed NCT00376818
43 Acute Side Effects in Patients Who Are Undergoing Stereotactic Radiosurgery for Brain Tumors or Other Brain Disorders Completed NCT00255671
44 Intrathecal Radioimmunotherapy, Radiation Therapy, and Chemotherapy After Surgery in Treating Patients With Medulloblastoma Active, not recruiting NCT00058370 cisplatin;lomustine;vincristine sulfate
45 Ga-DOTATOC Versus Octreoscan + CT Suspended NCT01869725
46 Gadobutrol Versus Gadopentetate Dimeglumine or Gadobenate Dimeglumine Before DCE-MRI in Diagnosing Patients With Multiple Sclerosis, Grade II-IV Glioma, or Brain Metastases Terminated NCT02967380 Gadobenate Dimeglumine;Gadobutrol
47 Yoga Therapy in Treating Patients With Malignant Brain Tumors Terminated NCT01234805
48 Efficacy of 68Ga-DOTATOC Positron Emission Tomography (PET) CT in Children and Young Adults With Brain Tumors Withdrawn NCT02194452
49 Perfusion Magnetic Resonance Imaging in Measuring the Growth of Blood Vessels in Newly Diagnosed Brain Tumors Withdrawn NCT00005790

Search NIH Clinical Center for Adult Medulloblastoma

Genetic Tests for Adult Medulloblastoma

Anatomical Context for Adult Medulloblastoma

MalaCards organs/tissues related to Adult Medulloblastoma:

38
Brain, Bone, Bone Marrow, Liver

Publications for Adult Medulloblastoma

Articles related to Adult Medulloblastoma:

(show top 50) (show all 66)
# Title Authors Year
1
Long-term outcomes of adult medulloblastoma patients treated with radiotherapy. ( 29019042 )
2018
2
Distinctive localization and MRI features correlate of molecular subgroups in adult medulloblastoma. ( 28808827 )
2017
3
Patterns of Failure in Patients With Adult Medulloblastoma Presenting Without Extraneural Metastasis. ( 29045264 )
2017
4
Comment on: Adjuvant chemotherapy in adult medulloblastoma: is it an option for average-risk patients? ( 27278608 )
2016
5
Adult medulloblastoma: A rare case report and literature review. ( 27512610 )
2016
6
Molecular subgroups of adult medulloblastoma: a long-term single-institution study. ( 27106407 )
2016
7
Dynamic susceptibility contrast perfusion imaging in biopsy-proved adult medulloblastoma. ( 27262628 )
2016
8
Adjuvant chemotherapy in adult medulloblastoma: is it an option for average-risk patients? ( 26940908 )
2016
9
Adjuvant chemotherapy and overall survival in adult medulloblastoma. ( 27540083 )
2016
10
Multicenter experience of adult medulloblastoma: A study of Anatolian Society of Medical Oncology (ASMO). ( 27273958 )
2016
11
Complete and sustained response of adult medulloblastoma to first-line sonic hedgehog inhibition with vismodegib. ( 27682250 )
2016
12
Outcomes of adult medulloblastoma treated with a multimodality approach: A tertiary cancer center experience. ( 26981508 )
2015
13
Adult medulloblastoma: clinical characters, prognostic factors, outcomes and patterns of relapse. ( 26026861 )
2015
14
Chemotherapy increases long-term survival in patients with adult medulloblastoma-a literature-based meta-analysis. ( 26359208 )
2015
15
Radiotherapy for adult medulloblastoma: Long term result from a single institution. A review of prognostic factors and why we do need a multi-institutional cooperative program. ( 26109916 )
2015
16
Extracranial recurrence in the bone marrow of adult medulloblastoma patient - a therapeutic trap. ( 25778341 )
2015
17
Adult medulloblastoma: feasibility and effectiveness of utilising high-dose chemotherapy with autologous stem cell rescue in newly diagnosed patients. ( 24528821 )
2014
18
Deep Sequencing Identifies IDH1 R132S Mutation in Adult Medulloblastoma. ( 24616312 )
2014
19
Patterns of care in adult medulloblastoma: results of an international online survey. ( 25026996 )
2014
20
Cushing's reflex in a rare case of adult medulloblastoma. ( 25215166 )
2014
21
Neuroradiology and histopathology in two cases of adult medulloblastoma. ( 24750703 )
2014
22
Adult medulloblastoma: a single institution experience. ( 25316389 )
2014
23
Shedding light on adult medulloblastoma: current management and opportunities for advances. ( 24857151 )
2014
24
New perspectives in the treatment of adult medulloblastoma in the era of molecular oncology. ( 25600839 )
2014
25
Comprehensive high-resolution genomic profiling and cytogenetics of two pediatric and one adult medulloblastoma. ( 23896263 )
2013
26
Retreatment of recurrent adult medulloblastoma with radiotherapy: a case report and review of the literature. ( 23497715 )
2013
27
Local perspective on a rare brain tumour: adult medulloblastoma. ( 23279053 )
2013
28
Adult medulloblastoma associated with syringomyelia: a case report. ( 23691470 )
2012
29
Adult medulloblastoma: multiagent chemotherapy with cisplatinum and etoposide: a single institutional experience. ( 21874383 )
2012
30
Update on molecular and genetic alterations in adult medulloblastoma. ( 23864912 )
2012
31
Unusual presentation in adult medulloblastomas: imaging features mimicking cerebellar dysplastic gangliocytoma (Lhermitte-Duclos disease). ( 23135053 )
2012
32
The role of radiotherapy in adult medulloblastoma: long-term single-institution experience and a review of the literature. ( 21805324 )
2012
33
A tale of two tumors: pediatric and adult medulloblastoma. ( 23330354 )
2012
34
A rare case of adult medulloblastoma with spinal metastasis. ( 23056969 )
2012
35
Adult medulloblastoma, from spongioblastoma cerebelli to the present day: a review of treatment and the integration of molecular markers. ( 23330353 )
2012
36
Radiation-induced adult medulloblastoma: a two-case report and review of the literature. ( 20936325 )
2011
37
Atypical adult medulloblastoma. ( 21553317 )
2011
38
Preponderance of sonic hedgehog pathway activation characterizes adult medulloblastoma. ( 21107850 )
2011
39
Adult medulloblastoma comprises three major molecular variants. ( 21632505 )
2011
40
Adult medulloblastoma mimicking Lhermitte-Duclos disease: can diffusion weighted imaging help? ( 19439857 )
2009
41
Adult medulloblastoma and the "dural-tail" sign: rare mimic of a posterior petrous meningioma. ( 19285790 )
2009
42
Survival of patients with adult medulloblastoma: a population-based study. ( 18278809 )
2008
43
MATH-1 production by an adult medulloblastoma suggestive of a cerebellar external granule cell precursor origin. ( 18032051 )
2008
44
Adult medulloblastoma: clinical profile and treatment results of 18 patients. ( 18078755 )
2008
45
Neuroimaging abnormalities in adult medulloblastoma undergoing intensified therapy. ( 19192661 )
2008
46
Boost Gamma Knife surgery during multimodality management of adult medulloblastoma. ( 18240913 )
2008
47
Craniospinal radiotherapy in adult medulloblastoma. ( 17497094 )
2007
48
Cytogenetic and molecular biological characterization of an adult medulloblastoma. ( 17954265 )
2007
49
Adult medulloblastoma relapse visualized by in-111 octreotide scintigraphy. ( 16985373 )
2006
50
Radiation induced adult medulloblastoma: a case report. ( 16710747 )
2006

Variations for Adult Medulloblastoma

Expression for Adult Medulloblastoma

Search GEO for disease gene expression data for Adult Medulloblastoma.

Pathways for Adult Medulloblastoma

GO Terms for Adult Medulloblastoma

Cellular components related to Adult Medulloblastoma according to GeneCards Suite gene sharing:

# Name GO ID Score Top Affiliating Genes
1 cytosol GO:0005829 9.77 BRPF1 EIF5B ENO2 GFAP GLI1 IDH1
2 MOZ/MORF histone acetyltransferase complex GO:0070776 8.8 BRPF1 KAT6A KAT6B

Biological processes related to Adult Medulloblastoma according to GeneCards Suite gene sharing:

(show all 27)
# Name GO ID Score Top Affiliating Genes
1 negative regulation of gene expression GO:0010629 9.88 MDM2 MYCN SFRP1 SHH
2 negative regulation of transcription, DNA-templated GO:0045892 9.88 KAT6A KAT6B MDM2 PTCH1 SFRP1 TP53
3 lung development GO:0030324 9.79 GLI1 MYCN SHH
4 canonical Wnt signaling pathway GO:0060070 9.77 GLI1 SFRP1 SHH
5 neural tube closure GO:0001843 9.76 PTCH1 SFRP1 SUFU
6 regulation of signal transduction by p53 class mediator GO:1901796 9.76 BRPF1 KAT6A MDM2 TP53
7 smoothened signaling pathway GO:0007224 9.74 GLI1 PTCH1 SHH
8 response to organic cyclic compound GO:0014070 9.73 IDH1 PTCH1 SFRP1 TP53
9 negative regulation of osteoblast differentiation GO:0045668 9.7 PTCH1 SFRP1 SUFU
10 histone H3 acetylation GO:0043966 9.69 BRPF1 KAT6A KAT6B
11 dorsal/ventral pattern formation GO:0009953 9.65 GLI1 PTCH1 SHH
12 somite development GO:0061053 9.63 PTCH1 SHH
13 dorsal/ventral neural tube patterning GO:0021904 9.62 PTCH1 SHH
14 cellular response to estrogen stimulus GO:0071391 9.62 MDM2 SFRP1
15 Bergmann glial cell differentiation GO:0060020 9.56 GFAP SHH
16 spinal cord dorsal/ventral patterning GO:0021513 9.54 SHH SUFU
17 smoothened signaling pathway involved in regulation of cerebellar granule cell precursor cell proliferation GO:0021938 9.49 GLI1 SHH
18 positive regulation of smoothened signaling pathway GO:0045880 9.43 GLI1 SFRP1 SHH
19 ventral midline development GO:0007418 9.37 GLI1 SHH
20 prostate gland development GO:0030850 9.33 GLI1 PTCH1 SHH
21 cellular response to actinomycin D GO:0072717 9.32 MDM2 TP53
22 positive regulation of transcription, DNA-templated GO:0045893 9.28 BRPF1 GLI1 KAT6A KAT6B MYCN PTCH1
23 digestive tract morphogenesis GO:0048546 9.13 GLI1 SFRP1 SHH
24 regulation of transcription, DNA-templated GO:0006355 10.28 ATOH1 BRPF1 GLI1 KAT6A KAT6B MYCN
25 positive regulation of transcription by RNA polymerase II GO:0045944 10.09 ATOH1 GLI1 KAT6B MYCN PPP1R12A SHH
26 negative regulation of apoptotic process GO:0043066 10 ATOH1 MDM2 SFRP1 SHH TP53
27 positive regulation of cell proliferation GO:0008284 10 GLI1 MDM2 MYCN SFRP1 SHH

Molecular functions related to Adult Medulloblastoma according to GeneCards Suite gene sharing:

# Name GO ID Score Top Affiliating Genes
1 acetyltransferase activity GO:0016407 8.96 KAT6A KAT6B
2 patched binding GO:0005113 8.62 PTCH1 SHH

Sources for Adult Medulloblastoma

3 CDC
7 CNVD
9 Cosmic
10 dbSNP
11 DGIdb
16 ExPASy
18 FMA
27 GO
28 GTR
29 HGMD
30 HMDB
31 HPO
32 ICD10
33 ICD10 via Orphanet
34 ICD9CM
35 IUPHAR
36 KEGG
37 LifeMap
39 MedGen
41 MeSH
42 MESH via Orphanet
43 MGI
45 NCI
46 NCIt
47 NDF-RT
50 NINDS
51 Novoseek
53 OMIM
54 OMIM via Orphanet
58 PubMed
60 QIAGEN
65 SNOMED-CT via HPO
66 SNOMED-CT via Orphanet
67 TGDB
68 Tocris
69 UMLS
70 UMLS via Orphanet
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