MEST
MCID: ADL014
MIFTS: 28

Adult Mesoblastic Nephroma (MEST) malady

Categories: Cancer diseases, Nephrological diseases, Rare diseases

Aliases & Classifications for Adult Mesoblastic Nephroma

Aliases & Descriptions for Adult Mesoblastic Nephroma:

Name: Adult Mesoblastic Nephroma 12 14
Benign Mixed Epithelial and Stromal Tumor of Kidney 69
Mixed Epithelial and Stromal Tumour of Kidney 12
Benign Mest 12
Mest 12

Classifications:



External Ids:

Disease Ontology 12 DOID:2678
SNOMED-CT 64 388985009
UMLS 69 C1272677

Summaries for Adult Mesoblastic Nephroma

Disease Ontology : 12 A mixed neoplasm that is seen mostly in early infancy and that consists of classic and cellular (atypical) variants.

MalaCards based summary : Adult Mesoblastic Nephroma, also known as benign mixed epithelial and stromal tumor of kidney, is related to silver-russell syndrome and diabetes mellitus, transient neonatal, 1, and has symptoms including flank pain An important gene associated with Adult Mesoblastic Nephroma is NTRK3 (Neurotrophic Receptor Tyrosine Kinase 3). The drugs Fentanyl and pancreatic polypeptide have been mentioned in the context of this disorder. Affiliated tissues include kidney.

Related Diseases for Adult Mesoblastic Nephroma

Graphical network of the top 20 diseases related to Adult Mesoblastic Nephroma:



Diseases related to Adult Mesoblastic Nephroma

Symptoms & Phenotypes for Adult Mesoblastic Nephroma

UMLS symptoms related to Adult Mesoblastic Nephroma:


flank pain

Drugs & Therapeutics for Adult Mesoblastic Nephroma

Drugs for Adult Mesoblastic Nephroma (from DrugBank, HMDB, Dgidb, PharmGKB, IUPHAR, NovoSeek, BitterDB):

(show all 26)
id Name Status Phase Clinical Trials Cas Number PubChem Id
1
Fentanyl Approved, Illicit, Investigational, Vet_approved Phase 3 437-38-7 3345
2 pancreatic polypeptide Phase 3
3 Analgesics Phase 3
4 Adjuvants, Anesthesia Phase 3
5 Narcotics Phase 3
6 Analgesics, Opioid Phase 3
7 Anesthetics Phase 3
8 Anesthetics, General Phase 3
9 Anesthetics, Intravenous Phase 3
10 Peripheral Nervous System Agents Phase 3
11 Liver Extracts Phase 3,Phase 1,Phase 2
12 Central Nervous System Depressants Phase 3
13 Cola Nutraceutical Phase 3
14
Etoposide Approved Phase 1, Phase 2 33419-42-0 36462
15
Carboplatin Approved Phase 1, Phase 2 41575-94-4 10339178 498142 38904
16
Dasatinib Approved, Investigational Phase 1, Phase 2 302962-49-8 3062316
17
Ifosfamide Approved Phase 1, Phase 2 3778-73-2 3690
18
Mechlorethamine Approved Phase 1, Phase 2 51-75-2 4033
19 Alkylating Agents Phase 1, Phase 2
20 Topoisomerase Inhibitors Phase 1, Phase 2
21 Etoposide phosphate Phase 1, Phase 2
22 Protein Kinase Inhibitors Phase 1, Phase 2
23 Isophosphamide mustard Phase 1, Phase 2
24 Antineoplastic Agents, Alkylating Phase 1, Phase 2
25 Antineoplastic Agents, Phytogenic Phase 1, Phase 2
26 tyrosine Nutraceutical Phase 1

Interventional clinical trials:


id Name Status NCT ID Phase
1 Fentanyl Sublingual Spray in Treating Patients With Breakthrough Cancer Pain Completed NCT00538850 Phase 3
2 Oral TRK Inhibitor LOXO-101 (Larotrectinib) for Treatment of Advanced Pediatric Solid or Primary Central Nervous System Tumors Recruiting NCT02637687 Phase 1, Phase 2
3 Dasatinib, Ifosfamide, Carboplatin, and Etoposide in Treating Young Patients With Metastatic or Recurrent Malignant Solid Tumors Active, not recruiting NCT00788125 Phase 1, Phase 2
4 Study of RXDX-101 in Children With Recurrent or Refractory Solid Tumors and Primary CNS Tumors, With or Without TRK, ROS1, or ALK Fusions Recruiting NCT02650401 Phase 1
5 Study of Genes and Environment in Patients With Cancer in East Anglia, Trent, or West Midlands Regions of the United Kingdom Unknown status NCT00757614
6 Study of Kidney Tumors in Younger Patients Recruiting NCT00898365
7 Studying Biomarkers in Samples From Younger Patients With Kidney Cancer Withdrawn NCT01642095

Search NIH Clinical Center for Adult Mesoblastic Nephroma

Genetic Tests for Adult Mesoblastic Nephroma

Anatomical Context for Adult Mesoblastic Nephroma

MalaCards organs/tissues related to Adult Mesoblastic Nephroma:

39
Kidney

Publications for Adult Mesoblastic Nephroma

Articles related to Adult Mesoblastic Nephroma:

id Title Authors Year
1
Multiphasic contrast-enhanced CT and MRI findings of adult mesoblastic nephroma: A report of two cases. ( 23986620 )
2013
2
Mixed epithelial and stromal tumor of the kidney or adult mesoblastic nephroma: an update. ( 20845287 )
2010
3
Adult mesoblastic nephroma: a case with fatal recurrence. ( 18592471 )
2008
4
Adult mesoblastic nephroma: appearances on magnetic resonance imaging. ( 15288147 )
2004
5
Adult mesoblastic nephroma with ciliated epithelium. A case report. ( 10782471 )
2000
6
Adult mesoblastic nephroma. ( 10707372 )
2000
7
Adult mesoblastic nephroma: expansion of the morphologic spectrum and review of literature. ( 9669345 )
1998
8
A case of adult mesoblastic nephroma: ultrastructure and discussion of histogenesis. ( 2160549 )
1990

Variations for Adult Mesoblastic Nephroma

Expression for Adult Mesoblastic Nephroma

Search GEO for disease gene expression data for Adult Mesoblastic Nephroma.

Pathways for Adult Mesoblastic Nephroma

GO Terms for Adult Mesoblastic Nephroma

Biological processes related to Adult Mesoblastic Nephroma according to GeneCards Suite gene sharing:

id Name GO ID Score Top Affiliating Genes
1 cell differentiation GO:0030154 9.33 CHL1 ETV6 NTRK3
2 neuron migration GO:0001764 8.96 CHL1 NTRK3
3 hematopoietic stem cell proliferation GO:0071425 8.62 CD34 ETV6

Sources for Adult Mesoblastic Nephroma

3 CDC
7 CNVD
9 Cosmic
10 dbSNP
11 DGIdb
16 ExPASy
18 FMA
28 GO
29 GTR
30 HGMD
31 HMDB
32 HPO
33 ICD10
34 ICD10 via Orphanet
35 ICD9CM
36 IUPHAR
37 KEGG
38 LifeMap
40 MedGen
42 MeSH
43 MESH via Orphanet
44 MGI
46 NCI
47 NCIt
48 NDF-RT
51 NINDS
52 Novoseek
54 OMIM
55 OMIM via Orphanet
59 PubMed
60 QIAGEN
65 SNOMED-CT via Orphanet
67 TGDB
68 Tocris
69 UMLS
70 UMLS via Orphanet
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