MCID: ADL030
MIFTS: 57

Adult-Onset Still's Disease malady

Categories: Rare diseases, Nephrological diseases, Bone diseases

Aliases & Classifications for Adult-Onset Still's Disease

About this section
Sources:
11Disease Ontology, 13DISEASES, 30ICD10, 31ICD10 via Orphanet, 39MeSH, 40MESH via Orphanet, 48NIH Rare Diseases, 50Novoseek, 54Orphanet, 62SNOMED-CT, 68UMLS, 69UMLS via Orphanet
See all MalaCards sources

Aliases & Descriptions for Adult-Onset Still's Disease:

Name: Adult-Onset Still's Disease 11 48 13
Adult-Onset Still Disease 11 54 68
Still's Disease, Adult-Onset 39
Still's Disease Adult Onset 48
Adult Onset Still's Disease 11
 
Stills Disease Adult-Onset 50
Wissler-Fanconi Syndrome 54
Adult Still's Disease 48
Wissler's Syndrome 68
Aosd 54

Characteristics:

Orphanet epidemiological data:

54
adult-onset still disease:
Inheritance: Not applicable; Prevalence: 1-9/1000000 (France),1-9/1000000 (Japan),1-9/1000000 (Norway),1-9/100000 (Norway),1-9/100000 (Europe),1-9/1000000 (Turkey),1-9/100000 (Turkey); Age of onset: Adult; Age of death: normal life expectancy

Classifications:



External Ids:

Disease Ontology11 DOID:14256
ICD1030 M06.1
MeSH39 D016706
Orphanet54 ORPHA829
ICD10 via Orphanet31 M06.1
UMLS via Orphanet69 C0085253, C0043195
MESH via Orphanet40 D014924, D016706

Summaries for Adult-Onset Still's Disease

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NIH Rare Diseases:48 Adult-onset Still's disease is an inflammatory condition characterized by high fevers, rash, sore throat, and joint pain. As it progresses, adult-onset Still's disease may lead to chronic arthritis and other complications. Still's disease was named after an English doctor named George Still, who described the condition in children in 1896. Still's disease which occurs in children (those under the age of 16) is now known as systemic onset juvenile rheumatoid arthritis (JRA). In 1971, the term adult Still's disease was used to describe adults who had a condition similar to systemic onset JRA. The cause of adult-onset Still's disease is unknown. No risk factors for the disease have been identified. There's no cure for adult-onset Still's disease; however, treatment may offer symptom relief and help prevent complications.  Last updated: 5/28/2014

MalaCards based summary: Adult-Onset Still's Disease, also known as adult-onset still disease, is related to hemophagocytic lymphohistiocytosis and retroperitoneal fibrosis, and has symptoms including skin rash, pruritus and urticaria. An important gene associated with Adult-Onset Still's Disease is IL18 (Interleukin 18), and among its related pathways are Hypertrophy Model and Interleukin-1 processing. Affiliated tissues include liver, bone and skin, and related mouse phenotypes are Decreased shRNA abundance (Z-score < -2) and neoplasm.

Disease Ontology:11 An arthritis that is a rare from of inflammatory arthritis characterized by fevers, rash, and joint pain.

Related Diseases for Adult-Onset Still's Disease

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Diseases related to Adult-Onset Still's Disease via text searches within MalaCards or GeneCards Suite gene sharing:

(show top 50)    (show all 298)
idRelated DiseaseScoreTop Affiliating Genes
1hemophagocytic lymphohistiocytosis30.0IL6, TNF
2retroperitoneal fibrosis28.9IL1B, IL1RN, IL6, TNF
3wissler's syndrome11.1
4aneurysm of sinus of valsalva10.6CRP, IL6
5angioma hereditary neurocutaneous10.6CRP, IL6
6malignant gastric granular cell tumor10.5CRP, IL6
7chronic diarrhea due to guanylate cyclase 2c overactivity10.5CRP, IL6
8cyclothymic disorder10.5CRP, IL6
9queensland tick typhus10.5CRP, IL6
10opiate dependence10.5CRP, IL6
11aortic arch interruption10.5IL6, TNF
12arteriolosclerosis10.5IL18, IL6
13hyperthyroxinemia10.5CRP, TNF
14cutaneous leishmaniasis10.5IL6, TNF
15antidepressant type abuse10.5CRP, IL6
16maligant granulosa cell tumor of ovary10.5IL6, TNF
17hemometra10.5IL6, TNF
18tricho odonto onycho dermal syndrome10.5IL6, TNF
19substernal goiter10.5CRP, IL6
20tick-borne relapsing fever10.5CRP, TNF
21abdominal chemodectomas with cutaneous angiolipomas10.5IL6, TNF
22antigen-peptide-transporter 2 deficiency10.5IL6, TNF
23ethmoid sinus adenoid cystic carcinoma10.5IL6, TNF
24steatorrhea10.5IL18, TNF
25colon lymphoma10.5CRP, IL6
26splenic manifestation of prolymphocytic leukemia10.5IL6, TNF
27post-infectious myocarditis10.5IL6, TNF
28idiopathic neutropenia10.5CRP, IL6
29pasteurellosis10.5IL6, TNF
30astrocytoma10.5IL1R1, TNF
31lymphocytic colitis10.4IL6, TNF
32acquired thrombocytopenia10.4CRP, MEFV
33stromal predominant kidney wilms' tumor10.4CRP, IL1RN
34large cell carcinoma with rhabdoid phenotype10.4CRP, TNF
35atypical depressive disorder10.4IL6, TNF
36polyarteritis nodosa10.4CRP, MEFV
37porokeratosis 3, disseminated superficial actinic10.4CRP, IL1RN
38cerebral hemorrhage10.4CRP, IL1RN
39multiple sclerosis 510.4MEFV, TNF
40chromoblastomycosis10.4CRP, MEFV
41anterior dislocation of lens10.4CSF1, IL6
42polyradiculoneuropathy10.4IL1R1, IL6
43scrotum melanoma10.4CRP, IL18, IL6
44cauda equina syndrome10.4IL6, TNF
45acute porphyria10.4CRP, TNF
46tinea pedis10.4CRP, IL6
47iron metabolism disease10.3CRP, IL18, IL6
48corneal deposit10.3IL1B, IL6
49tarsal tunnel syndrome10.3IL1B, IL6
50oropharynx cancer10.3IL1R1, TNF

Graphical network of the top 20 diseases related to Adult-Onset Still's Disease:



Diseases related to adult-onset still's disease

Symptoms & Phenotypes for Adult-Onset Still's Disease

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Human phenotypes related to Adult-Onset Still's Disease:

 64 54 (show all 35)
id Description HPO Frequency Orphanet Frequency HPO Source Accession
1 skin rash64 54 hallmark (90%) Very frequent (99-80%) HP:0000988
2 pruritus64 54 hallmark (90%) Very frequent (99-80%) HP:0000989
3 urticaria64 hallmark (90%) HP:0001025
4 arthritis64 54 hallmark (90%) Very frequent (99-80%) HP:0001369
5 joint swelling64 54 hallmark (90%) Very frequent (99-80%) HP:0001386
6 splenomegaly64 54 hallmark (90%) Very frequent (99-80%) HP:0001744
7 leukocytosis64 54 hallmark (90%) Very frequent (99-80%) HP:0001974
8 restrictive ventilatory defect64 hallmark (90%) HP:0002091
9 hepatomegaly64 54 hallmark (90%) Very frequent (99-80%) HP:0002240
10 arthralgia64 54 hallmark (90%) Very frequent (99-80%) HP:0002829
11 abnormality of temperature regulation64 hallmark (90%) HP:0004370
12 abnormality of the pericardium64 typical (50%) HP:0001697
13 abdominal pain64 54 typical (50%) Frequent (79-30%) HP:0002027
14 abnormality of the pleura64 typical (50%) HP:0002103
15 myalgia64 54 typical (50%) Frequent (79-30%) HP:0003326
16 mediastinal lymphadenopathy64 typical (50%) HP:0100721
17 meningitis64 54 occasional (7.5%) Occasional (29-5%) HP:0001287
18 abnormality of the myocardium64 occasional (7.5%) HP:0001637
19 elevated hepatic transaminases64 54 occasional (7.5%) Occasional (29-5%) HP:0002910
20 abnormality of lipid metabolism64 54 occasional (7.5%) Occasional (29-5%) HP:0003119
21 bone marrow hypocellularity64 54 occasional (7.5%) Occasional (29-5%) HP:0005528
22 cartilage destruction64 54 occasional (7.5%) Occasional (29-5%) HP:0100773
23 recurrent pharyngitis64 54 occasional (7.5%) Occasional (29-5%) HP:0100776
24 pericarditis54 Frequent (79-30%)
25 fever54 Very frequent (99-80%)
26 restrictive lung disease54 Very frequent (99-80%)
27 pleuritis54 Frequent (79-30%)
28 elevated erythrocyte sedimentation rate54 Very frequent (99-80%)
29 generalized lymphadenopathy54 Frequent (79-30%)
30 erythema54 Very frequent (99-80%)
31 elevated c-reactive protein level54 Very frequent (99-80%)
32 neutrophillia54 Very frequent (99-80%)
33 hepatitis54 Occasional (29-5%)
34 fatigue54 Very frequent (99-80%)
35 myocarditis54 Occasional (29-5%)

UMLS symptoms related to Adult-Onset Still's Disease:


exanthema

GenomeRNAi Phenotypes related to Adult-Onset Still's Disease according to GeneCards Suite gene sharing:

26
idDescriptionGenomeRNAi Source AccessionScoreTop Affiliating Genes
1GR00366-A-588.2CSF1, IL1B, IL1R1, MIF

MGI Mouse Phenotypes related to Adult-Onset Still's Disease according to GeneCards Suite gene sharing:

41
idDescriptionMGI Source AccessionScoreTop Affiliating Genes
1MP:00020068.6IL1B, IL1R1, IL6, MIF, TNF
2MP:00053708.2CSF1, IL1R1, IL6, MEFV, TNF
3MP:00053907.3CSF1, IL1B, IL1R1, IL1RN, IL6, MEFV
4MP:00036317.2CSF1, IL18, IL1B, IL1R1, IL6, MIF
5MP:00053846.9CSF1, IL18, IL1R1, IL1RN, IL6, MEFV
6MP:00107716.9CSF1, IL18, IL1B, IL1R1, IL1RN, IL6
7MP:00053856.8CRP, CSF1, IL18, IL1B, IL1R1, IL1RN
8MP:00053976.3CSF1, IL18, IL1B, IL1R1, IL1RN, IL6
9MP:00053876.0CRP, CSF1, IL18, IL1B, IL1R1, IL1RN
10MP:00053765.8CRP, CSF1, IL18, IL1B, IL1R1, IL1RN

Drugs & Therapeutics for Adult-Onset Still's Disease

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Drugs for Adult-Onset Still's Disease (from DrugBank, HMDB, Dgidb, PharmGKB, IUPHAR, NovoSeek, BitterDB):

(show all 14)
idNameStatusPhaseClinical TrialsCas NumberPubChem Id
1
Methylprednisoloneapproved, vet_approvedPhase 2115383-43-26741
Synonyms:
(6S,8S,9S,10R,11S,13S,14S,17R)-11,17-dihydroxy-17-(2-hydroxyacetyl)-6,10,13-trimethyl-7,8,9,11,12,14,15,16-octahydro-6H-cyclopenta[a]phenanthren-3-one
(6a,11b)-11,17,21-Trihydroxy-6-methylpregna-1,4-diene-3,20-dione
(6alpha,11beta)-11,17,21-Trihydroxy-6-methylpregna-1,4-diene-3,20-dione
(6α,11β)-11,17,21-trihydroxy-6-methylpregna-1,4-diene-3,20-dione
.DELTA.1-6.alpha.-Methylhydrocortisone
1-Dehydro-6alpha-methylhydrocortisone
1-dehydro-6alpha-Methylhydrocortisone
1-dehydro-6α-methylhydrocortisone
11-beta,17,21-Trihydroxy-6-alpha-methylpregna-1,4-diene-3,20-dione
11beta,17,21-Trihydroxy-6alpha-methylpregna-1,4-diene-3,20-dione
11beta,17alpha,21-Trihydroxy-6alpha-methyl-1,4-pregnadiene-3,20-dione
11beta,17alpha,21-Trihydroxy-6alpha-methylpregna-1,4-diene-3,20-dione
121673-01-6
4-08-00-03498 (Beilstein Handbook Reference)
46436_FLUKA
46436_RIEDEL
570-35-4
6 Methylprednisolone
6-Methylprednisolone
6-alpha-Methylprednisolone
6.alpha.-Methylprednisolone
6923-42-8
6alpha-Methyl-11beta,17alpha,21-trihydroxy-1,4-pregnadiene-3,20-dione
6alpha-Methyl-11beta,17alpha,21-triol-1,4-pregnadiene-3,20-dione
6alpha-Methylprednisolone
6alpha-methyl-11beta,17alpha,21-triol-1,4-pregnadiene-3,20-dione
83-43-2
AC1L1N7A
Artisone-Wyeth
Artisone-wyeth
BPBio1_000174
BRD-K35240538-001-03-1
BRN 2340300
BSPBio_000158
Besonia
Bio-0658
CHEBI:6888
CHEMBL650
CID6741
CPD000058330
D00407
D008775
DB00959
Depo-Medrol (acetate)
Dopomedrol
EINECS 201-476-4
Esametone
Firmacort
HMS1568H20
HMS2090B13
HSDB 3127
LMST02030178
LS-118498
Lemod
M0639_SIGMA
M1665
MEPRDL
MLS000028541
MLS001148159
MLS002207191
Medesone
Medixon
Medlone 21
 
Medrate
Medrol
Medrol (TN)
Medrol Adt Pak
Medrol Dosepak
Medrol adt pak
Medrol dosepak
Medrol, Solu-Medrol, Medrone, Methylprednisolone
Medrone
Mesopren
Metastab
Methyleneprednisolone
Methylprednisolon
Methylprednisolone
Methylprednisolone (JP15/USP/INN)
Methylprednisolone [USAN:INN:BAN:JAN]
Methylprednisolone, 6-alpha
Methylprednisolonum
Methylprednisolonum [INN-Latin]
Metilbetasone
Metilprednisolona
Metilprednisolona [INN-Spanish]
Metilprednisolone
Metilprednisolone [DCIT]
Metilprednisolone [Dcit]
Metipred
Metrisone
Metrocort
Metysolon
Moderin
MolPort-002-528-554
NCGC00022735-03
NCI60_001657
NSC-19987
NSC19987
Nirypan
Noretona
Predni N Tablinen
Prednol- L
Pregna-1,4-diene-3,20-dione, 11beta,17,21-trihydroxy-6alpha-methyl- (8CI)
Prestwick0_000279
Prestwick1_000279
Prestwick2_000279
Prestwick3_000279
Prestwick_622
Promacortine
Reactenol
S1733_Selleck
SAM002589984
SMR000058330
SPBio_002377
Sieropresol
Solomet
Summicort
Suprametil
U 7532
UNII-X4W7ZR7023
Urbason
Urbasone
Wyacort
ZINC03875560
delta(1)-6alpha-Methylhydrocortisone
delta(sup 1)-6-alpha-Methylhydrocortisone
methylprednisolone
methylprenisolone
2
MethotrexateapprovedPhase 215181959-05-2, 59-05-2126941
Synonyms:
4-amino-10-methylfolic acid
4-amino-N(10)-Methylpteroylglutamic acid
Abitrexate
Amethopterin
Amethopterine
Antifolan
Arbitrexate
Emtexate
Folex
HDMTX
L-Amethopterin
Ledertrexate
MTX
Metatrexan
 
Methopterin
Methotextrate
Methotrate
Methotrexat
Methotrexate Sodium
Methotrexatum
Methylaminopterin
Methylaminopterinum
Metotrexato
Mexate
Méthotrexate
N-Bismethylpteroylglutamic Acid
N-[4-[[(2,4-Diamino-6-pteridinyl)methyl]methylamino]benzoyl]-L-glutamic acid
Rheumatrex
Trexall
3
Prednisoloneapproved, vet_approvedPhase 2115350-24-85755
Synonyms:
(11beta)-11,17,21-Trihydroxypregna-1,4-diene-3,20-dione
.DELTA.1-Cortisol
.DELTA.1-Dehydrocortisol
.DELTA.1-Dehydrohydrocortisone
.DELTA.1-Hydrocortisone
.delta.-Cortef
.delta.-Stab
1,2-Dehydrohydrocortisone
1,4-Pregnadiene-11beta,17alpha,21-triol-3,20-dione
1,4-Pregnadiene-3,20-dione-11beta,17alpha,21-triol
1-Dehydrocortisol
1-Dehydrohydrocortisone
3,20-dioxo-11beta,17alpha,21-Trihydroxy-1,4-pregnadiene
46656_FLUKA
46656_RIEDEL
50-24-8
58201-11-9
8056-11-9
AC-1773
AC1L1L2E
Ak-Pred
Ak-Tate
Alphadrol
Articulose-50
BPBio1_000164
BRD-K98039984-001-03-0
BRN 1354103
BSPBio_000148
Bio-0666
Bubbli-Pred
C07369
CCRIS 980
CHEBI:8378
CHEMBL131
CID5755
CO-Hydeltra
CPD000718761
Co-Hydeltra
Codelcortone
Cordrol
Cortalone
Cotogesic
Cotolone
D00472
D011239
DB00860
Decaprednil
Decortin H
Delcortol
Delta F
Delta(1)-dehydrohydrocortisone
Delta-Cortef
Delta-Cortef (TN)
Delta-Ef-Cortelan
Delta-Stab
Delta-stab
Deltacortenol
Deltacortril
Deltacortril Enteric
Deltahydrocortisone
Deltasolone
Deltisilone
Depo-Medrol
Derpo PD
Derpo Pd
Dexa-Cortidelt Hostacortin H
Dexa-Cortidelt hostacortin H
Di Adreson F
Di-Adreson F
Di-Adreson-F
Di-adreson F
DiAdresonF
Dicortol
Donisolone
Dydeltrone
EINECS 200-021-7
Eazolin D
Econopred
Econopred Plus
Erbacort
Erbasona
Estilsona
Fernisolone
Fernisolone P
Fernisolone-P
Flamasone
HMS1568H10
HMS2090J05
HSDB 3385
Hostacortin H
Hydeltra
Hydeltra-Tba
Hydeltrasol
Hydeltrone
Hydrodeltalone
Hydrodeltisone
Hydroretrocortin
Hydroretrocortine
I-Pred
Inflamase Forte
Inflamase Mild
K 1557
Key-Pred
Klismacort
LMST02030179
LS-7669
Lentosone
Lite Pred
M-Predrol
 
MLS001304083
MLS002154250
MLS002207037
Medrol
Medrol Acetate
Metacortandralone
Methylprednisolone Acetate
Meti-Derm
Meticortelone
Metreton
MolPort-002-507-147
NCGC00179649-01
NSC 9120
NSC9120
NSC9900
Neo-Delta-Cortef
Nisolone
Nor-Pred T.B.A.
Ocu-Pred
Ocu-Pred Forte
Ophtho-Tate
Orapred
P0152_SIGMA
P0637
P6004_SIGMA
PRDL
PRED-G
Panafcortelone
Paracortol
Paracotol
Pediapred
Poly-Pred
Precortalon
Precortancyl
Precortilon
Precortisyl
Pred Forte
Pred Mild
Predair
Predair A
Predair Forte
Predalone 50
Predalone T.B.A.
Predate
Predate Tba
Predate-50
Predcor-25
Predcor-50
Predcor-Tba
Predisolone Sodium Phosphate
Predne-Dome
Prednelan
Predni-Dome
Prednicen
Predniliderm
Predniretard
Prednis
Prednisolona
Prednisolona [INN-Spanish]
Prednisolone (JP15/USP/INN)
Prednisolone (anhydrous)
Prednisolone Acetate
Prednisolone Sodium Phosphate
Prednisolone Tebutate
Prednisolone [INN:BAN:JAN]
Prednisolonum
Prednisolonum [INN-Latin]
Predonin
Predonine
Prelone
Prenolone
Prestwick0_000274
Prestwick1_000274
Prestwick2_000274
Prestwick3_000274
Prestwick_404
Rolisone
S1737_Selleck
SAM002264639
SMR000718761
SPBio_002367
Scherisolon
Solone
Steran
Sterane
Sterolone
Supercortisol
UNII-9PHQ9Y1OLM
Ulacort
Ultra Pred
Ultracorten H
Ultracortene H
Ultracortene-H
Ultracortene-Hydrogen
Ultracortene-hydrogen
ZINC03833821
component of Ataraxoid
component of K-Predne-Dome
delta(1)-Cortisol
delta(1)-Dehydrocortisol
delta(1)-Dehydrohydrocortisone
delta(1)-Hydrocortisone
delta(sup 1)-Cortisol
delta(sup 1)-Dehydrocortisol
delta(sup 1)-Dehydrohydrocortisone
delta(sup 1)-Hydrocortisone
delta-dehydrocortisol
delta-dehydrohydrocortisone
delta-hydrocortisone
prednisolone
4Prednisolone phosphatePhase 21153
5AntibodiesPhase 26045
6Antibodies, MonoclonalPhase 23795
7ImmunoglobulinsPhase 26045
8Interleukin 1 Receptor Antagonist ProteinPhase 296
9Prednisolone hemisuccinatePhase 21153
10Methylprednisolone acetatePhase 21153
11Prednisolone acetatePhase 21153
12Methylprednisolone HemisuccinatePhase 21153
13Antirheumatic AgentsPhase 210627
14Chelating AgentsPhase 21365

Interventional clinical trials:

idNameStatusNCT IDPhase
1Treatment of Refractory Adult-onset Still's Disease With Anakinra: a Randomized StudyUnknown statusNCT01033656Phase 2
2Efficacy and Safety of Tocilizumab in Adult's Still DiseaseUnknown statusNCT01002781Phase 2
3Therapeutic Use of Tadekinig Alfa in Adult-onset Still's DiseaseCompletedNCT02398435Phase 2
4Interleukin-1 Trap to Treat Autoinflammatory DiseasesCompletedNCT00094900Phase 2
5The Empowerment Model Towards Type 2 Diabetic Adults To Enhance Vegetable Intake in Achieving Glycemic ControlCompletedNCT01828242Phase 2
6Canakinumab for Treatment of Adult Onset Still's DiseaseRecruitingNCT02204293Phase 2
7Glycosylated Ferritin in Macrophagic Activation SyndromesRecruitingNCT02143986

Search NIH Clinical Center for Adult-Onset Still's Disease


Cochrane evidence based reviews: still's disease, adult-onset

Genetic Tests for Adult-Onset Still's Disease

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Anatomical Context for Adult-Onset Still's Disease

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MalaCards organs/tissues related to Adult-Onset Still's Disease:

36
Liver, Bone, Skin, Lung, Lymph node, T cells, Bone marrow

Publications for Adult-Onset Still's Disease

About this section

Articles related to Adult-Onset Still's Disease:

(show top 50)    (show all 597)
idTitleAuthorsYear
1
A Rare Ocular Manifestation of Adult Onset Still's Disease: Purtscher's-like Retinopathy. (27599266)
2016
2
Adult onset Still's disease accompanied by acute respiratory distress syndrome: A case report. (27588099)
2016
3
Adult onset Still's disease with dermatopathic lymphadenopathy. (27761568)
2016
4
Macrophage activation syndrome complicating adult onset Still's disease: A single center case series and comparison with literature. (26672682)
2016
5
A case report of successful treatment of 90A^ knee flexion contracture in a patient with adult-onset Still's disease. (26860205)
2016
6
Macrophage Activation Syndrome Associated with Adult-Onset Still's Disease Successfully Treated with Anakinra. (27818826)
2016
7
Adult-onset Still's disease: current challenges and future prospects. (27843366)
2016
8
Elevated serum levels of free interleukin-18 in adult-onset Still's disease. (27616144)
2016
9
H-ferritin and CD68(+) /H-ferritin(+) monocytes/macrophages are increased in the skin of adult-onset Still's disease patients and correlate with the multi-visceral involvement of the disease. (27317930)
2016
10
Atypical Cutaneous Manifestations in Adult Onset Still's Disease. (26981304)
2016
11
Adult-onset Still's disease: Advances in the treatment. (27886796)
2016
12
TLR4 Endogenous Ligand S100A8/A9 Levels in Adult-Onset Still's Disease and Their Association with Disease Activity and Clinical Manifestations. (27537874)
2016
13
Pulmonary arterial hypertension in adult onset Still's disease: a case report of a severe complication. (27160441)
2016
14
Successful treatment of refractory adult onset Still's disease with rituximab. (27981819)
2016
15
Epidemiological study of adult-onset Still's disease using a Japanese administrative database. (27502500)
2016
16
Adult Onset Still's Disease Associated with Mycoplasma pneumoniae Infection and Hemophagocytic Lymphohistiocytosis. (27847518)
2016
17
Metabolic Disturbances in Adult-Onset Still's Disease Evaluated Using Liquid Chromatography/Mass Spectrometry-Based Metabolomic Analysis. (28005947)
2016
18
Bartonella henselae infection presenting with a picture of adult-onset Still's disease. (27000538)
2016
19
Resolution of severe pulmonary arterial hypertension complicating adult-onset Still's disease. (27216503)
2016
20
Clinical characteristics and follow-up analysis of adult-onset Still's disease complicated by hemophagocytic lymphohistiocytosis. (26809798)
2016
21
Successful Tocilizumab Therapy for Macrophage Activation Syndrome Associated with Adult-Onset Still's Disease: A Case-Based Review. (27688774)
2016
22
Macrophage activation syndrome associated with tocilizumab treatment in adult-onset Still's disease. (27778518)
2016
23
Macrophage activation syndrome triggered by disseminated tuberculosis with tuberculous gumma in a patient with adult-onset Still's disease and Good's syndrome. (27018416)
2016
24
Elevated high-mobility group B1 levels in active adult-onset Still's disease associated with systemic score and skin rash. (27225247)
2016
25
Adult Onset Still's Disease With Different Antibodies: A Case Report and Review of Literature. (27888598)
2016
26
Adult-onset Still's disease-like manifestation accompanied by the cancer recurrence after long-term resting state. (27846765)
2016
27
Persistent Pruritic Lesions in Adult-onset Still's Disease. (27865305)
2016
28
A retrospective study of patients with adult-onset Still's disease: is pericarditis a possible predictor for biological disease-modifying anti-rheumatic drugs need? (26758435)
2016
29
Histological findings in the spleen affected by adult-onset Still's disease: a report of three cases. (26841850)
2016
30
Herpes Zoster Meningitis Complicating Combined Tocilizumab and Cyclosporine Therapy for Adult-Onset Still's Disease. (27092286)
2016
31
An atypical presentation of adult-onset Still's disease complicated by pulmonary hypertension and macrophage activation syndrome treated with immunosuppression: a case-based review of the literature. (27162622)
2016
32
Efficacy of Low-Dose Tocilizumab on Relapsing Adult-Onset Still's Disease. (27131353)
2016
33
Adult Onset Still's Disease: A Review on Diagnostic Workup and Treatment Options. (27042373)
2016
34
Pulmonary arterial hypertension secondary to adult-onset Still's disease: Response to cyclosporine and sildenafil over 15 years of follow-up. (27408785)
2016
35
Combination Immunosuppressive Therapy Including Rituximab for Epstein-Barr Virus-Associated Hemophagocytic Lymphohistiocytosis in Adult-Onset Still's Disease. (28018698)
2016
36
Intravitreal dexamethasone implants for the treatment of refractory scleritis combined with uveitis in adult-onset Still's disease: a case report. (27825329)
2016
37
Adult-onset Still's disease: an Italian multicentre retrospective observational study of manifestations and treatments in 245 patients. (27207567)
2016
38
Adult-onset Still's disease: evaluation of prognostic tools and validation of the systemic score by analysis of 100 cases from three centers. (27903264)
2016
39
Adult onset still's disease- A rare presentation. (27728682)
2016
40
Limited diagnostic value of procalcitonin in early diagnosis of adult onset Still's disease. (27826176)
2016
41
Efficacy of tocilizumab therapy in Korean patients with adult-onset Still's disease: a multicentre retrospective study of 22 cases. (27462914)
2016
42
The role of 18F-fluorodeoxyglucose positron emission tomography in the assessment of disease activity of adult-onset Still's disease. (27926812)
2016
43
Neonatal Haemophagocytic Lymphohistiocytosis Associated with Maternal Adult-Onset Still's Disease. (27304999)
2016
44
Response rate of initial conventional treatments, disease course, and related factors of patients with adult-onset Still's disease: Data from a large multicenter cohort. (26970681)
2016
45
Cytokine profile in adult-onset Still's disease: Comparison with systemic juvenile idiopathic arthritis. (27263804)
2016
46
Adult-onset Still's disease with myocarditis and hemophagocytic lymphohistiocytosis: Rare manifestation with fatal outcome. (26960645)
2016
47
A Case of Adult-Onset Still's Disease Treated with Monitoring of Serum Tacrolimus Levels. (26535602)
2015
48
The CD68+/H-ferritin+ cells colonize the lymph nodes of the patients with Adult onset Still's disease and are associated with increased extracellular level of H-ferritin in the same tissue. Correlation with disease severity and implication for pathogenesis. (26540556)
2015
49
A Case of Gloves and Socks Syndrome and Related Eruptions Caused by Coxsackievirus A4 Infection Mimicking Adult-onset Still's Disease. (26120191)
2015
50
Two Cases of Adult-onset Still's Disease Treated with Tocilizumab that Achieved Tocilizumab-free Remission. (26466710)
2015

Variations for Adult-Onset Still's Disease

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Expression for genes affiliated with Adult-Onset Still's Disease

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Search GEO for disease gene expression data for Adult-Onset Still's Disease.

Pathways for genes affiliated with Adult-Onset Still's Disease

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Pathways related to Adult-Onset Still's Disease according to GeneCards Suite gene sharing:

(show all 49)
idSuper pathwaysScoreTop Affiliating Genes
19.8IL18, IL1R1
29.7IL18, IL1B
39.6IL1B, IL6
4
Show member pathways
9.3IL18, IL1B, IL6
5
Show member pathways
9.2IL18, IL1B, IL1R1
6
Show member pathways
9.2IL1B, IL1R1, IL6
79.2IL18, IL1B, TNF
8
Show member pathways
9.2IL1B, IL1R1, IL1RN
99.2IL1B, IL6, TNF
109.2IL1B, IL6, TNF
119.2IL1B, IL6, TNF
129.2IL1B, IL6, TNF
139.2IL6, MIF, TNF
149.2IL6, MIF, TNF
15
Show member pathways
9.1IL1B, IL1R1, TNF
169.1IL1B, IL1R1, TNF
17
Show member pathways
8.9IL18, IL1B, IL1R1, IL6
188.9IL18, IL1B, IL6, TNF
19
Show member pathways
8.9IL18, IL1B, IL6, TNF
208.9IL18, IL1B, IL6, TNF
218.9CSF1, IL6, TNF
22
Show member pathways
8.9IL18, IL1B, IL6, TNF
23
Show member pathways
8.9IL18, IL1B, IL6, TNF
248.9IL18, IL1B, IL6, TNF
25
Show member pathways
8.9IL18, IL1B, IL6, TNF
26
Show member pathways
8.9IL18, IL1B, IL6, TNF
278.9IL18, IL1B, IL6, TNF
288.8IL18, IL1B, IL1R1, TNF
298.8IL1B, IL1RN, IL6, TNF
30
Show member pathways
8.7IL1B, IL1R1, IL6, TNF
31
Show member pathways
8.7IL1B, IL1R1, IL6, TNF
328.7IL1B, IL1R1, IL6, TNF
338.7CSF1, IL1B, TNF
348.4CSF1, IL18, IL1B, TNF
358.3CSF1, IL1B, IL6, TNF
368.3CSF1, IL1B, IL6, TNF
378.3CSF1, IL1B, IL6, TNF
388.3CSF1, IL1B, IL1R1, TNF
39
Show member pathways
8.2IL18, IL1B, IL6, MEFV, TNF
408.2IL1B, IL1R1, IL6, MIF, TNF
41
Show member pathways
8.2IL1B, IL1R1, IL6, MIF, TNF
42
Show member pathways
8.1IL18, IL1B, IL1R1, IL1RN, IL6, TNF
438.0CSF1, IL18, IL1B, IL6, TNF
448.0CSF1, IL18, IL1B, IL6, TNF
457.9CSF1, IL1B, IL1R1, IL6, TNF
46
Show member pathways
7.6CSF1, IL18, IL1B, IL1R1, IL6, TNF
47
Show member pathways
7.6CSF1, IL18, IL1B, IL1R1, IL6, TNF
48
Show member pathways
7.1CRP, IL18, IL1B, IL1R1, IL1RN, IL6
49
Show member pathways
7.1CSF1, IL18, IL1B, IL1R1, IL6, MIF

GO Terms for genes affiliated with Adult-Onset Still's Disease

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Cellular components related to Adult-Onset Still's Disease according to GeneCards Suite gene sharing:

idNameGO IDScoreTop Affiliating Genes
1vesicleGO:00319829.1IL1B, IL1RN, MIF
2extracellular regionGO:00055768.4CRP, IL18, IL1B, IL1RN, IL6, MIF
3extracellular spaceGO:00056157.0CRP, CSF1, IL18, IL1B, IL1R1, IL1RN

Biological processes related to Adult-Onset Still's Disease according to GeneCards Suite gene sharing:

(show all 38)
idNameGO IDScoreTop Affiliating Genes
1negative regulation of myoblast differentiationGO:004566210.4IL18, TNF
2epithelial cell proliferation involved in salivary gland morphogenesisGO:006066410.4IL6, TNF
3positive regulation of chemokine productionGO:003272210.4IL6, TNF
4positive regulation of granulocyte macrophage colony-stimulating factor productionGO:003272510.3IL18, IL1B
5ovulationGO:003072810.3IL1B, IL1R1
6chronic inflammatory response to antigenic stimulusGO:000243910.2IL1B, TNF
7negative regulation of lipid catabolic processGO:005099510.2IL1B, TNF
8positive regulation of calcidiol 1-monooxygenase activityGO:006055910.2IL1B, TNF
9positive regulation of chemokine biosynthetic processGO:004508010.2IL1B, TNF
10positive regulation of chemokine (C-X-C motif) ligand 2 productionGO:200034310.2MIF, TNF
11positive regulation of cytokine secretionGO:005071510.2MIF, TNF
12positive regulation of fever generationGO:003162210.2IL1B, TNF
13positive regulation of heterotypic cell-cell adhesionGO:003411610.2IL1B, TNF
14positive regulation of interleukin-8 productionGO:003275710.2IL1B, TNF
15positive regulation of membrane protein ectodomain proteolysisGO:005104410.2IL1B, TNF
16defense response to Gram-positive bacteriumGO:005083010.1CRP, IL6, TNF
17negative regulation of lipid storageGO:001088810.1CRP, IL6, TNF
18regulation of establishment of endothelial barrierGO:190314010.0IL1B, TNF
19regulation of I-kappaB kinase/NF-kappaB signalingGO:004312210.0IL1B, TNF
20cellular response to organic cyclic compoundGO:00714079.9IL18, IL1B, TNF
21cytokine-mediated signaling pathwayGO:00192219.9IL1B, IL1R1, IL6
22lipopolysaccharide-mediated signaling pathwayGO:00316639.9IL18, IL1B, TNF
23osteoclast differentiationGO:00303169.9CSF1, TNF
24positive regulation of interferon-gamma productionGO:00327299.9IL18, IL1B, TNF
25positive regulation of NF-kappaB import into nucleusGO:00423469.9IL18, IL1B, TNF
26positive regulation of osteoclast differentiationGO:00456729.8CSF1, TNF
27positive regulation of interleukin-6 productionGO:00327559.8IL1B, IL6, TNF
28positive regulation of NF-kappaB transcription factor activityGO:00510929.8IL1B, IL6, TNF
29positive regulation of nitric oxide biosynthetic processGO:00454299.8IL1B, IL6, TNF
30positive regulation of peptidyl-serine phosphorylationGO:00331389.8IL6, MIF, TNF
31leukocyte migrationGO:00509009.7IL1B, MIF, TNF
32positive regulation of sequence-specific DNA binding transcription factor activityGO:00510919.7IL1B, IL6, TNF
33positive regulation of protein phosphorylationGO:00019349.6IL1B, MIF, TNF
34sequestering of triglycerideGO:00307309.5IL1B, TNF
35response to glucocorticoidGO:00513849.4IL1RN, IL6, TNF
36positive regulation of ERK1 and ERK2 cascadeGO:00703749.3IL1B, IL6, MIF, TNF
37positive regulation of gene expressionGO:00106288.4CRP, CSF1, IL18, IL1B, IL6, TNF
38inflammatory responseGO:00069547.3CRP, CSF1, IL18, IL1B, IL6, MEFV

Molecular functions related to Adult-Onset Still's Disease according to GeneCards Suite gene sharing:

idNameGO IDScoreTop Affiliating Genes
1cytokine activityGO:00051257.1CSF1, IL18, IL1B, IL1RN, IL6, MIF

Sources for Adult-Onset Still's Disease

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2CDC
6CNVD
10DGIdb
15ExPASy
16FDA
17FMA
27GTR
28HGMD
29HMDB
30ICD10
31ICD10 via Orphanet
32ICD9CM
33IUPHAR
34KEGG
37MedGen
39MeSH
40MESH via Orphanet
41MGI
44NCI
45NCIt
46NDF-RT
49NINDS
50Novoseek
52OMIM
53OMIM via Orphanet
57PubMed
58QIAGEN
63SNOMED-CT via Orphanet
67Tumor Gene Family of Databases
68UMLS
69UMLS via Orphanet