MCID: ADL030
MIFTS: 57

Adult-Onset Still's Disease malady

Categories: Rare diseases, Nephrological diseases, Bone diseases

Aliases & Classifications for Adult-Onset Still's Disease

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Sources:
11Disease Ontology, 46NIH Rare Diseases, 13DISEASES, 52Orphanet, 66UMLS, 48Novoseek, 37MeSH, 28ICD10, 29ICD10 via Orphanet, 38MESH via Orphanet, 67UMLS via Orphanet, 60SNOMED-CT
See all MalaCards sources

Aliases & Descriptions for Adult-Onset Still's Disease:

Name: Adult-Onset Still's Disease 11 46 13
Adult-Onset Still Disease 11 52 66
Still's Disease, Adult-Onset 37
Still's Disease Adult Onset 46
Adult Onset Still's Disease 11
 
Stills Disease Adult-Onset 48
Wissler-Fanconi Syndrome 52
Adult Still's Disease 46
Wissler's Syndrome 66
Aosd 52

Characteristics:

Orphanet epidemiological data:

52
adult-onset still disease:
Inheritance: Not applicable; Prevalence: 1-9/1000000 (France),1-9/1000000 (Japan),1-9/1000000 (Norway),1-9/100000 (Norway),1-9/100000 (Europe),1-9/1000000 (Turkey),1-9/100000 (Turkey); Age of onset: Adult; Age of death: normal life expectancy

Classifications:



External Ids:

Disease Ontology11 DOID:14256
ICD1028 M06.1
MeSH37 D016706
Orphanet52 ORPHA829
ICD10 via Orphanet29 M06.1
MESH via Orphanet38 D014924, D016706
UMLS via Orphanet67 C0043195, C0085253

Summaries for Adult-Onset Still's Disease

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NIH Rare Diseases:46 Adult-onset still's disease is an inflammatory condition characterized by high fevers, rash, sore throat, and joint pain. as it progresses, adult-onset still's disease may lead to chronic arthritis and other complications. still's disease was named after an english doctor named george still, who described the condition in children in 1896. still's disease which occurs in children (those under the age of 16) is now known as systemic onset juvenile rheumatoid arthritis (jra). in 1971, the term "adult still's disease" was used to describe adults who had a condition similar to systemic onset jra. the cause of adult-onset still's disease is unknown. no risk factors for the disease have been identified. there's no cure for adult-onset still's disease; however, treatment may offer symptom relief and help prevent complications.  last updated: 5/28/2014

MalaCards based summary: Adult-Onset Still's Disease, also known as adult-onset still disease, is related to hemophagocytic lymphohistiocytosis and retroperitoneal fibrosis, and has symptoms including skin rash, pruritus and urticaria. An important gene associated with Adult-Onset Still's Disease is IL1RN (Interleukin 1 Receptor Antagonist), and among its related pathways are Interleukin-1 processing and IL-9 Signaling Pathways and their Primary Biological Effects in Different Immune Cell Types. Affiliated tissues include liver, bone and skin, and related mouse phenotypes are integument and skeleton.

Disease Ontology:11 An arthritis that is a rare from of inflammatory arthritis characterized by fevers, rash, and joint pain.

Related Diseases for Adult-Onset Still's Disease

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Diseases related to Adult-Onset Still's Disease via text searches within MalaCards or GeneCards Suite gene sharing:

(show top 50)    (show all 333)
idRelated DiseaseScoreTop Affiliating Genes
1hemophagocytic lymphohistiocytosis30.1IL6, TNF
2retroperitoneal fibrosis29.3IL1B, IL1RN, IL6, TNF
3wissler's syndrome11.2
4aneurysm of sinus of valsalva10.7CRP, IL6
5angioma hereditary neurocutaneous10.7CRP, IL6
6stromal predominant kidney wilms' tumor10.7CRP, IL1RN
7porokeratosis 3, disseminated superficial actinic10.6CRP, IL1RN
8cerebral hemorrhage10.6CRP, IL1RN
9malignant gastric granular cell tumor10.6CRP, IL6
10chronic diarrhea due to guanylate cyclase 2c overactivity10.6CRP, IL6
11cyclothymic disorder10.6CRP, IL6
12queensland tick typhus10.6CRP, IL6
13opiate dependence10.6CRP, IL6
14antidepressant type abuse10.6CRP, IL6
15arteriolosclerosis10.6IL18, IL6
16substernal goiter10.6CRP, IL6
17aortic arch interruption10.6IL6, TNF
18cutaneous leishmaniasis10.6IL6, TNF
19hyperthyroxinemia10.5CRP, TNF
20acquired thrombocytopenia10.5CRP, MEFV
21hemometra10.5IL6, TNF
22tricho odonto onycho dermal syndrome10.5IL6, TNF
23tick-borne relapsing fever10.5CRP, TNF
24polyarteritis nodosa10.5CRP, MEFV
25abdominal chemodectomas with cutaneous angiolipomas10.5IL6, TNF
26antigen-peptide-transporter 2 deficiency10.5IL6, TNF
27colon lymphoma10.5CRP, IL6
28ethmoid sinus adenoid cystic carcinoma10.5IL6, TNF
29prostate calculus10.5CXCL8, IL18
30protozoal dysentery10.5CRP, CXCL8
31idiopathic neutropenia10.5CRP, IL6
32chromoblastomycosis10.5CRP, MEFV
33primrose syndrome10.5CRP, IL1RN
34cardiocranial syndrome10.5CRP, CXCL8
35steatorrhea10.5IL18, TNF
36splenic manifestation of prolymphocytic leukemia10.5IL6, TNF
37post-infectious myocarditis10.5IL6, TNF
38multiple sclerosis 510.5MEFV, TNF
39anterior dislocation of lens10.5CXCL8, IL6
40hemoglobinopathy10.5IL1B, IL6
41lymphocytic colitis10.5IL6, TNF
42retinal vascular disease10.5CXCL8, IL6
43cervical incompetence10.5CXCL8, IL18
44benign adult familial myoclonic epilepsy10.5CXCL8, IL6
45melorheostosis10.5IL1B, IL6
46gastric cancer risk after h. pylori infection10.5IL1B, IL1RN
47acute posterior multifocal placoid pigment epitheliopathy10.5CXCL8, IL6
48mixed connective tissue disease10.5CRP, TNF
49mental retardation anophthalmia craniosynostosis10.4IL1B, IL1RN
50large cell carcinoma with rhabdoid phenotype10.4CRP, TNF

Graphical network of the top 20 diseases related to Adult-Onset Still's Disease:



Diseases related to adult-onset still's disease

Symptoms for Adult-Onset Still's Disease

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Symptoms:

 52 (show all 28)
  • skin rash
  • pruritus
  • meningitis
  • arthritis
  • joint swelling
  • pericarditis
  • splenomegaly
  • fever
  • leukocytosis
  • abdominal pain
  • restrictive lung disease
  • pleuritis
  • hepatomegaly
  • arthralgia
  • elevated hepatic transaminases
  • abnormality of lipid metabolism
  • myalgia
  • elevated erythrocyte sedimentation rate
  • bone marrow hypocellularity
  • generalized lymphadenopathy
  • erythema
  • elevated c-reactive protein level
  • neutrophillia
  • hepatitis
  • fatigue
  • myocarditis
  • cartilage destruction
  • recurrent pharyngitis

HPO human phenotypes related to Adult-Onset Still's Disease:

(show all 23)
id Description Frequency HPO Source Accession
1 skin rash hallmark (90%) HP:0000988
2 pruritus hallmark (90%) HP:0000989
3 urticaria hallmark (90%) HP:0001025
4 arthritis hallmark (90%) HP:0001369
5 joint swelling hallmark (90%) HP:0001386
6 splenomegaly hallmark (90%) HP:0001744
7 leukocytosis hallmark (90%) HP:0001974
8 restrictive ventilatory defect hallmark (90%) HP:0002091
9 hepatomegaly hallmark (90%) HP:0002240
10 arthralgia hallmark (90%) HP:0002829
11 abnormality of temperature regulation hallmark (90%) HP:0004370
12 abnormality of the pericardium typical (50%) HP:0001697
13 abdominal pain typical (50%) HP:0002027
14 abnormality of the pleura typical (50%) HP:0002103
15 myalgia typical (50%) HP:0003326
16 mediastinal lymphadenopathy typical (50%) HP:0100721
17 meningitis occasional (7.5%) HP:0001287
18 abnormality of the myocardium occasional (7.5%) HP:0001637
19 elevated hepatic transaminases occasional (7.5%) HP:0002910
20 abnormality of lipid metabolism occasional (7.5%) HP:0003119
21 bone marrow hypocellularity occasional (7.5%) HP:0005528
22 cartilage destruction occasional (7.5%) HP:0100773
23 recurrent pharyngitis occasional (7.5%) HP:0100776

UMLS symptoms related to Adult-Onset Still's Disease:


exanthema

Drugs & Therapeutics for Adult-Onset Still's Disease

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Drugs for Adult-Onset Still's Disease (from DrugBank, HMDB, Dgidb, PharmGKB, IUPHAR, NovoSeek, BitterDB):

idNameStatusPhaseClinical TrialsCas NumberPubChem Id
1PREDNISOLONE ACETATEPhase 21118
2
PrednisolonePhase 2111850-24-85755
Synonyms:
(11beta)-11,17,21-Trihydroxypregna-1,4-diene-3,20-dione
.DELTA.1-Cortisol
.DELTA.1-Dehydrocortisol
.DELTA.1-Dehydrohydrocortisone
.DELTA.1-Hydrocortisone
.delta.-Cortef
.delta.-Stab
1,2-Dehydrohydrocortisone
1,4-Pregnadiene-11beta,17alpha,21-triol-3,20-dione
1,4-Pregnadiene-3,20-dione-11beta,17alpha,21-triol
1-Dehydrocortisol
1-Dehydrohydrocortisone
3,20-dioxo-11beta,17alpha,21-Trihydroxy-1,4-pregnadiene
46656_FLUKA
46656_RIEDEL
50-24-8
58201-11-9
8056-11-9
AC-1773
AC1L1L2E
Ak-Pred
Ak-Tate
Alphadrol
Articulose-50
BPBio1_000164
BRD-K98039984-001-03-0
BRN 1354103
BSPBio_000148
Bio-0666
Bubbli-Pred
C07369
CCRIS 980
CHEBI:8378
CHEMBL131
CID5755
CO-Hydeltra
CPD000718761
Co-Hydeltra
Codelcortone
Cordrol
Cortalone
Cotogesic
Cotolone
D00472
D011239
DB00860
Decaprednil
Decortin H
Delcortol
Delta F
Delta(1)-dehydrohydrocortisone
Delta-Cortef
Delta-Cortef (TN)
Delta-Ef-Cortelan
Delta-Stab
Delta-stab
Deltacortenol
Deltacortril
Deltacortril Enteric
Deltahydrocortisone
Deltasolone
Deltisilone
Depo-Medrol
Derpo PD
Derpo Pd
Dexa-Cortidelt Hostacortin H
Dexa-Cortidelt hostacortin H
Di Adreson F
Di-Adreson F
Di-Adreson-F
Di-adreson F
DiAdresonF
Dicortol
Donisolone
Dydeltrone
EINECS 200-021-7
Eazolin D
Econopred
Econopred Plus
Erbacort
Erbasona
Estilsona
Fernisolone
Fernisolone P
Fernisolone-P
Flamasone
HMS1568H10
HMS2090J05
HSDB 3385
Hostacortin H
Hydeltra
Hydeltra-Tba
Hydeltrasol
Hydeltrone
Hydrodeltalone
Hydrodeltisone
Hydroretrocortin
Hydroretrocortine
I-Pred
Inflamase Forte
Inflamase Mild
K 1557
Key-Pred
Klismacort
LMST02030179
LS-7669
Lentosone
Lite Pred
M-Predrol
 
MLS001304083
MLS002154250
MLS002207037
Medrol
Medrol Acetate
Metacortandralone
Methylprednisolone Acetate
Meti-Derm
Meticortelone
Metreton
MolPort-002-507-147
NCGC00179649-01
NSC 9120
NSC9120
NSC9900
Neo-Delta-Cortef
Nisolone
Nor-Pred T.B.A.
Ocu-Pred
Ocu-Pred Forte
Ophtho-Tate
Orapred
P0152_SIGMA
P0637
P6004_SIGMA
PRDL
PRED-G
Panafcortelone
Paracortol
Paracotol
Pediapred
Poly-Pred
Precortalon
Precortancyl
Precortilon
Precortisyl
Pred Forte
Pred Mild
Predair
Predair A
Predair Forte
Predalone 50
Predalone T.B.A.
Predate
Predate Tba
Predate-50
Predcor-25
Predcor-50
Predcor-Tba
Predisolone Sodium Phosphate
Predne-Dome
Prednelan
Predni-Dome
Prednicen
Predniliderm
Predniretard
Prednis
Prednisolona
Prednisolona [INN-Spanish]
Prednisolone (JP15/USP/INN)
Prednisolone (anhydrous)
Prednisolone Acetate
Prednisolone Sodium Phosphate
Prednisolone Tebutate
Prednisolone [INN:BAN:JAN]
Prednisolonum
Prednisolonum [INN-Latin]
Predonin
Predonine
Prelone
Prenolone
Prestwick0_000274
Prestwick1_000274
Prestwick2_000274
Prestwick3_000274
Prestwick_404
Rolisone
S1737_Selleck
SAM002264639
SMR000718761
SPBio_002367
Scherisolon
Solone
Steran
Sterane
Sterolone
Supercortisol
UNII-9PHQ9Y1OLM
Ulacort
Ultra Pred
Ultracorten H
Ultracortene H
Ultracortene-H
Ultracortene-Hydrogen
Ultracortene-hydrogen
ZINC03833821
component of Ataraxoid
component of K-Predne-Dome
delta(1)-Cortisol
delta(1)-Dehydrocortisol
delta(1)-Dehydrohydrocortisone
delta(1)-Hydrocortisone
delta(sup 1)-Cortisol
delta(sup 1)-Dehydrocortisol
delta(sup 1)-Dehydrohydrocortisone
delta(sup 1)-Hydrocortisone
delta-dehydrocortisol
delta-dehydrohydrocortisone
delta-hydrocortisone
prednisolone
3
MethylprednisolonePhase 2111883-43-26741
Synonyms:
(6S,8S,9S,10R,11S,13S,14S,17R)-11,17-dihydroxy-17-(2-hydroxyacetyl)-6,10,13-trimethyl-7,8,9,11,12,14,15,16-octahydro-6H-cyclopenta[a]phenanthren-3-one
(6a,11b)-11,17,21-Trihydroxy-6-methylpregna-1,4-diene-3,20-dione
(6alpha,11beta)-11,17,21-Trihydroxy-6-methylpregna-1,4-diene-3,20-dione
(6α,11β)-11,17,21-trihydroxy-6-methylpregna-1,4-diene-3,20-dione
.DELTA.1-6.alpha.-Methylhydrocortisone
1-Dehydro-6alpha-methylhydrocortisone
1-dehydro-6alpha-Methylhydrocortisone
1-dehydro-6α-methylhydrocortisone
11-beta,17,21-Trihydroxy-6-alpha-methylpregna-1,4-diene-3,20-dione
11beta,17,21-Trihydroxy-6alpha-methylpregna-1,4-diene-3,20-dione
11beta,17alpha,21-Trihydroxy-6alpha-methyl-1,4-pregnadiene-3,20-dione
11beta,17alpha,21-Trihydroxy-6alpha-methylpregna-1,4-diene-3,20-dione
121673-01-6
4-08-00-03498 (Beilstein Handbook Reference)
46436_FLUKA
46436_RIEDEL
570-35-4
6 Methylprednisolone
6-Methylprednisolone
6-alpha-Methylprednisolone
6.alpha.-Methylprednisolone
6923-42-8
6alpha-Methyl-11beta,17alpha,21-trihydroxy-1,4-pregnadiene-3,20-dione
6alpha-Methyl-11beta,17alpha,21-triol-1,4-pregnadiene-3,20-dione
6alpha-Methylprednisolone
6alpha-methyl-11beta,17alpha,21-triol-1,4-pregnadiene-3,20-dione
83-43-2
AC1L1N7A
Artisone-Wyeth
Artisone-wyeth
BPBio1_000174
BRD-K35240538-001-03-1
BRN 2340300
BSPBio_000158
Besonia
Bio-0658
CHEBI:6888
CHEMBL650
CID6741
CPD000058330
D00407
D008775
DB00959
Depo-Medrol (acetate)
Dopomedrol
EINECS 201-476-4
Esametone
Firmacort
HMS1568H20
HMS2090B13
HSDB 3127
LMST02030178
LS-118498
Lemod
M0639_SIGMA
M1665
MEPRDL
MLS000028541
MLS001148159
MLS002207191
Medesone
Medixon
Medlone 21
 
Medrate
Medrol
Medrol (TN)
Medrol Adt Pak
Medrol Dosepak
Medrol adt pak
Medrol dosepak
Medrol, Solu-Medrol, Medrone, Methylprednisolone
Medrone
Mesopren
Metastab
Methyleneprednisolone
Methylprednisolon
Methylprednisolone
Methylprednisolone (JP15/USP/INN)
Methylprednisolone [USAN:INN:BAN:JAN]
Methylprednisolone, 6-alpha
Methylprednisolonum
Methylprednisolonum [INN-Latin]
Metilbetasone
Metilprednisolona
Metilprednisolona [INN-Spanish]
Metilprednisolone
Metilprednisolone [DCIT]
Metilprednisolone [Dcit]
Metipred
Metrisone
Metrocort
Metysolon
Moderin
MolPort-002-528-554
NCGC00022735-03
NCI60_001657
NSC-19987
NSC19987
Nirypan
Noretona
Predni N Tablinen
Prednol- L
Pregna-1,4-diene-3,20-dione, 11beta,17,21-trihydroxy-6alpha-methyl- (8CI)
Prestwick0_000279
Prestwick1_000279
Prestwick2_000279
Prestwick3_000279
Prestwick_622
Promacortine
Reactenol
S1733_Selleck
SAM002589984
SMR000058330
SPBio_002377
Sieropresol
Solomet
Summicort
Suprametil
U 7532
UNII-X4W7ZR7023
Urbason
Urbasone
Wyacort
ZINC03875560
delta(1)-6alpha-Methylhydrocortisone
delta(sup 1)-6-alpha-Methylhydrocortisone
methylprednisolone
methylprenisolone
4
MethotrexatePhase 214961959-05-2, 59-05-2126941
Synonyms:
4-amino-10-methylfolic acid
4-amino-N(10)-Methylpteroylglutamic acid
Abitrexate
Amethopterin
Amethopterine
Antifolan
Arbitrexate
Emtexate
Folex
HDMTX
L-Amethopterin
Ledertrexate
MTX
Metatrexan
 
Methopterin
Methotextrate
Methotrate
Methotrexat
Methotrexate Sodium
Methotrexatum
Methylaminopterin
Methylaminopterinum
Metotrexato
Mexate
Méthotrexate
N-Bismethylpteroylglutamic Acid
N-[4-[[(2,4-Diamino-6-pteridinyl)methyl]methylamino]benzoyl]-L-glutamic acid
Rheumatrex
Trexall

Interventional clinical trials:

idNameStatusNCT IDPhase
1Therapeutic Use of Tadekinig Alfa in Adult-onset Still's DiseaseCompletedNCT02398435Phase 2
2Interleukin-1 Trap to Treat Autoinflammatory DiseasesCompletedNCT00094900Phase 2
3The Empowerment Model Towards Type 2 Diabetic Adults To Enhance Vegetable Intake in Achieving Glycemic ControlCompletedNCT01828242Phase 2
4Canakinumab for Treatment of Adult Onset Still's DiseaseRecruitingNCT02204293Phase 2
5Treatment of Refractory Adult-onset Still's Disease With Anakinra: a Randomized StudyActive, not recruitingNCT01033656Phase 2
6Efficacy and Safety of Tocilizumab in Adult's Still DiseaseNot yet recruitingNCT01002781Phase 2
7Glycosylated Ferritin in Macrophagic Activation SyndromesRecruitingNCT02143986

Search NIH Clinical Center for Adult-Onset Still's Disease


Cochrane evidence based reviews: still's disease, adult-onset

Genetic Tests for Adult-Onset Still's Disease

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Anatomical Context for Adult-Onset Still's Disease

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MalaCards organs/tissues related to Adult-Onset Still's Disease:

34
Liver, Bone, Skin, Lung, Lymph node, T cells, Bone marrow

Animal Models for Adult-Onset Still's Disease or affiliated genes

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MGI Mouse Phenotypes related to Adult-Onset Still's Disease:

39
idDescriptionMGI Source AccessionScoreTop Affiliating Genes
1MP:00107718.5IL18, IL1B, IL1RN, IL6, MEFV, TNF
2MP:00053907.9FCGR2A, IL1B, IL1RN, IL6, MEFV, TNF
3MP:00053977.0FCGR2A, IL18, IL1B, IL1RN, IL6, MEFV
4MP:00053876.9CRP, FCGR2A, IL18, IL1B, IL1RN, IL6
5MP:00053766.8CRP, IL18, IL1B, IL1RN, IL6, MEFV

Publications for Adult-Onset Still's Disease

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Articles related to Adult-Onset Still's Disease:

(show top 50)    (show all 579)
idTitleAuthorsYear
1
A Rare Ocular Manifestation of Adult Onset Still's Disease: Purtscher's-like Retinopathy. (27599266)
2016
2
Adult onset Still's disease accompanied by acute respiratory distress syndrome: A case report. (27588099)
2016
3
A Case of Adult-Onset Still's Disease Treated with Monitoring of Serum Tacrolimus Levels. (26535602)
2015
4
The CD68+/H-ferritin+ cells colonize the lymph nodes of the patients with Adult onset Still's disease and are associated with increased extracellular level of H-ferritin in the same tissue. Correlation with disease severity and implication for pathogenesis. (26540556)
2015
5
A Case of Gloves and Socks Syndrome and Related Eruptions Caused by Coxsackievirus A4 Infection Mimicking Adult-onset Still's Disease. (26120191)
2015
6
Two Cases of Adult-onset Still's Disease Treated with Tocilizumab that Achieved Tocilizumab-free Remission. (26466710)
2015
7
Adult onset Still's disease (AOSD) in the era of biologic therapies: Dichotomous view for cytokine and clinical expressions. (25183244)
2014
8
Fever of unknown origin and leukemoid reaction as initial presentation of adult-onset Still's disease. (24811471)
2014
9
Tocilizumab in the treatment of the adult-onset Still's disease: current clinical evidence. (23108887)
2013
10
N2010 adult-onset Still's disease complicated by hemophagocytic syndrome and catastrophic antiphospholipid syndrome resulting in four limb amputation. (23781758)
2013
11
Interleukin-18 as an efficient marker for remission and follow-up in patients with inactive adult-onset Still's disease. (24134323)
2013
12
Mycoplasma pneumoniae infection associated with urticarial vasculitis mimicking adult-onset Still's disease. (21918897)
2012
13
Aseptic meningitis in adult onset Still's disease. (20495923)
2012
14
Adult Onset Still's Disease and Autoinflammation. (22988543)
2012
15
Adult-Onset Still's Disease Masquerading as Sepsis in an Asplenic Active Duty Soldier. (23251171)
2012
16
A rare presentation of endocarditis in adult-onset Still's disease in diagnosis of fever of unknown origin. (22210686)
2012
17
Adult-onset Still's disease: still a diagnosis of exclusion. A nested case-control study in patients with fever of unknown origin. (22510428)
2012
18
Suppurative necrotizing granulomatous lymphadenitis in adult-onset Still's disease: a case report. (23078628)
2012
19
Transient impairment of NK cell function in an infant born to a mother with adult-onset Still's disease: perinatal effect of maternal IL-18. (22572478)
2012
20
Benefit and a possible risk of tocilizumab therapy for adult-onset Still's disease accompanied by macrophage-activation syndrome. (20737186)
2011
21
A case of adult-onset Still's disease complicated with atypical pulmonary defect. (19809819)
2011
22
Onset of adult-onset Still's disease following influenza vaccination. (21327453)
2011
23
A case of adult-onset Still's disease complicated with diffuse alveolar hemorrhage. (19270830)
2009
24
Clinical features and prognosis of adult-onset still's disease: 61 cases from China. (19273456)
2009
25
Multicentric Castleman's disease mimicking adult-onset Still's disease. (19213588)
2009
26
Association of Fcgamma receptor polymorphisms with adult onset Still's disease in Korea. (19040302)
2009
27
Potential benefit of paracetamol administration in adult-onset Still's disease. (19776706)
2009
28
Steroid-resistant adult-onset Still's disease which showed a quick response to methotrexate. (18271807)
2008
29
Formation of numerous rice bodies: an unusual finding of adult-onset Still's disease. (18509715)
2008
30
Anakinra in patients with treatment-resistant adult-onset Still's disease: four case reports with serial cytokine measurements and a review of the literature. (17583775)
2007
31
Hemophagocytic syndrome in one patient with adult-onset Still's disease. Presentation with febrile neutropenia. (16550302)
2007
32
Celiac disease: association with adult-onset Still's disease: apropos of a clinical case. (17611347)
2007
33
Ten years of clinical experience with adult onset Still's disease: is the outcome improving? (17086384)
2007
34
Interleukin-1beta and interleukin-1 receptor antagonist gene polymorphisms in Korean patients with adult-onset Still's disease. (17963170)
2007
35
Interleukin 1 receptor antagonist therapy-induced thrombocytopenia in adult onset Still's disease. (17407250)
2007
36
Extremely high serum ferritin levels as diagnostic tool in adult-onset Still's disease. (17587648)
2007
37
Adult-onset Still's disease with persistent skin eruption and fatal respiratory failure in a Taiwanese woman. (17101495)
2006
38
Cytomegalovirus-associated hemophagocytic syndrome in a patient with adult onset Still's disease. (15789896)
2005
39
Refractory adult onset Still's disease and hypersensitivity to non-steroidal anti-inflammatory drugs and cyclo-oxygenase-2 inhibitors: are biological agents the solution? (16014669)
2005
40
Hepatitis A infection mimicking adult onset Still's disease. (10914871)
2000
41
Adult onset Still's disease presenting as aseptic meningitis in a young healthy female. (10363409)
1999
42
Adult-onset Still's disease in an oriental population: manifestations, course and outcome in 16 patients. (9588268)
1998
43
Adult onset Still's disease. 16 cases. (7567848)
1995
44
Inappropriate secretion of antidiuretic hormone (SIADH) in a patient with pleurisy related to adult onset Still's disease. (8719553)
1995
45
Osseous tuberculosis traced by magnetic resonance imaging in a patient with adult-onset Still's disease. (8508290)
1993
46
Adult-onset Still's disease in India. (1596706)
1992
47
Adult onset Still's disease and related renal amyloidosis. (2029209)
1991
48
Sensorineural hearing loss in adult onset Still's disease. (3401057)
1988
49
Adult-onset Still's disease: a case with onset during pregnancy. (4026893)
1985
50
Adult-onset Still's disease. (7086796)
1982

Variations for Adult-Onset Still's Disease

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Expression for genes affiliated with Adult-Onset Still's Disease

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Search GEO for disease gene expression data for Adult-Onset Still's Disease.

Pathways for genes affiliated with Adult-Onset Still's Disease

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Pathways related to Adult-Onset Still's Disease according to GeneCards Suite gene sharing:

(show all 50)
idSuper pathwaysScoreTop Affiliating Genes
19.7IL18, IL1B
29.6IL1B, IL6
39.6IL1B, TNF
49.3IL18, IL1B, TNF
59.3IL18, IL1B, TNF
69.3IL18, IL1B, TNF
79.2CXCL8, TNF
89.2IL1B, IL6, TNF
99.2IL1B, IL6, TNF
109.2IL1B, IL6, TNF
119.2IL1B, IL6, TNF
129.2IL1B, IL6, TNF
139.2IL1B, IL6, TNF
149.2FCGR2A, IL6, TNF
159.2FCGR2A, IL6, TNF
169.1FCGR2A, IL1B, TNF
17
Show member pathways
9.1FCGR2A, IL1B, TNF
189.1IL6, MIF, TNF
19
Show member pathways
8.9IL18, IL1B, IL6, TNF
20
Show member pathways
8.9IL18, IL1B, IL6, TNF
21
Show member pathways
8.9IL18, IL1B, IL6, TNF
228.9IL18, IL1B, IL6, TNF
23
Show member pathways
8.9CRP, IL1B, IL6, TNF
248.8CXCL8, IL1B, IL6
258.8CXCL8, IL1B, TNF
26
Show member pathways
8.5CXCL8, IL18, IL1B, IL6
27
Show member pathways
8.5CXCL8, IL18, IL1B, IL6
28
Show member pathways
8.4CXCL8, IL1B, IL6, TNF
29
Show member pathways
8.4CXCL8, IL1B, IL6, TNF
308.4CXCL8, IL1B, IL6, TNF
318.4CXCL8, IL1B, IL6, TNF
32
Show member pathways
8.4CXCL8, IL1B, IL6, TNF
338.4CXCL8, IL1B, IL6, TNF
34
Show member pathways
8.4CXCL8, IL1B, IL6, TNF
358.4FCGR2A, IL18, IL1B, IL6, TNF
368.2CXCL8, IL6, MIF, TNF
378.1CXCL8, IL1B, IL1RN, IL6, TNF
38
Show member pathways
8.1CXCL8, IL18, IL1B, IL6, TNF
39
Show member pathways
8.1CXCL8, IL18, IL1B, IL6, TNF
408.1CXCL8, IL18, IL1B, IL6, TNF
418.1CXCL8, IL18, IL1B, IL6, TNF
428.1CXCL8, IL18, IL1B, IL6, TNF
43
Show member pathways
8.1CXCL8, IL18, IL1B, IL6, TNF
448.1CXCL8, IL18, IL1B, IL6, TNF
45
Show member pathways
7.8CXCL8, IL1B, IL6, MIF, TNF
46
Show member pathways
7.8CXCL8, IL18, IL1B, IL1RN, IL6, TNF
47
Show member pathways
7.6CXCL8, IL18, IL1B, IL6, MEFV, TNF
48
Show member pathways
7.5CXCL8, IL18, IL1B, IL6, MIF, TNF
497.3CXCL8, FCGR2A, IL1B, IL6, MIF, TNF
50
Show member pathways
7.2CRP, FCGR2A, IL18, IL1B, IL1RN, IL6

GO Terms for genes affiliated with Adult-Onset Still's Disease

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Cellular components related to Adult-Onset Still's Disease according to GeneCards Suite gene sharing:

idNameGO IDScoreTop Affiliating Genes
1vesicleGO:00319829.1IL1B, IL1RN, MIF
2extracellular spaceGO:00056156.8CRP, CXCL8, IL18, IL1B, IL1RN, IL6
3extracellular regionGO:00055766.5CRP, CXCL8, IL18, IL1B, IL1RN, IL6

Biological processes related to Adult-Onset Still's Disease according to GeneCards Suite gene sharing:

(show all 37)
idNameGO IDScoreTop Affiliating Genes
1positive regulation of chemokine productionGO:003272210.4IL6, TNF
2epithelial cell proliferation involved in salivary gland morphogenesisGO:006066410.4IL6, TNF
3positive regulation of calcidiol 1-monooxygenase activityGO:006055910.3IL1B, TNF
4positive regulation of membrane protein ectodomain proteolysisGO:005104410.3IL1B, TNF
5sequestering of triglycerideGO:003073010.3IL1B, TNF
6chronic inflammatory response to antigenic stimulusGO:000243910.3IL1B, TNF
7regulation of establishment of endothelial barrierGO:190314010.3IL1B, TNF
8positive regulation of chemokine biosynthetic processGO:004508010.3IL1B, TNF
9positive regulation of heterotypic cell-cell adhesionGO:003411610.2IL1B, TNF
10positive regulation of fever generationGO:003162210.2IL1B, TNF
11negative regulation of lipid catabolic processGO:005099510.1IL1B, TNF
12regulation of I-kappaB kinase/NF-kappaB signalingGO:004312210.1IL1B, TNF
13positive regulation of chemokine (C-X-C motif) ligand 2 productionGO:200034310.0MIF, TNF
14positive regulation of granulocyte macrophage colony-stimulating factor productionGO:003272510.0IL18, IL1B
15negative regulation of myoblast differentiationGO:004566210.0IL18, TNF
16positive regulation of cytokine secretionGO:005071510.0MIF, TNF
17positive regulation of interleukin-8 productionGO:00327579.9IL1B, TNF
18response to glucocorticoidGO:00513849.9IL1RN, IL6, TNF
19positive regulation of NF-kappaB import into nucleusGO:00423469.9IL18, IL1B, TNF
20lipopolysaccharide-mediated signaling pathwayGO:00316639.9IL18, IL1B, TNF
21positive regulation of interferon-gamma productionGO:00327299.9IL18, IL1B, TNF
22negative regulation of lipid storageGO:00108889.9CRP, IL6, TNF
23embryonic digestive tract developmentGO:00485669.7CXCL8, TNF
24cellular response to organic cyclic compoundGO:00714079.7IL18, IL1B, TNF
25positive regulation of neutrophil chemotaxisGO:00900239.6CXCL8, IL1B
26positive regulation of NF-kappaB transcription factor activityGO:00510929.6IL1B, IL6, TNF
27positive regulation of sequence-specific DNA binding transcription factor activityGO:00510919.5IL1B, IL6, TNF
28positive regulation of interleukin-6 productionGO:00327559.5IL1B, IL6, TNF
29positive regulation of protein phosphorylationGO:00019349.4IL1B, MIF, TNF
30positive regulation of nitric oxide biosynthetic processGO:00454299.4IL1B, IL6, TNF
31defense response to Gram-positive bacteriumGO:00508309.3CRP, IL6, TNF
32cellular response to lipopolysaccharideGO:00712229.3CXCL8, IL6, TNF
33positive regulation of peptidyl-serine phosphorylationGO:00331389.2IL6, MIF, TNF
34leukocyte migrationGO:00509008.7IL1B, MIF, TNF
35positive regulation of ERK1 and ERK2 cascadeGO:00703748.6IL1B, IL6, MIF, TNF
36positive regulation of gene expressionGO:00106288.5CRP, IL18, IL1B, IL6, TNF
37inflammatory responseGO:00069546.9CRP, CXCL8, IL18, IL1B, IL6, MEFV

Molecular functions related to Adult-Onset Still's Disease according to GeneCards Suite gene sharing:

idNameGO IDScoreTop Affiliating Genes
1cytokine activityGO:00051258.0IL18, IL1B, IL1RN, IL6, MIF, TNF

Sources for Adult-Onset Still's Disease

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2CDC
6CNVD
10DGIdb
15ExPASy
16FDA
17FMA
25GTR
26HGMD
27HMDB
28ICD10
29ICD10 via Orphanet
30ICD9CM
31IUPHAR
32KEGG
35MedGen
37MeSH
38MESH via Orphanet
39MGI
42NCI
43NCIt
44NDF-RT
47NINDS
48Novoseek
50OMIM
51OMIM via Orphanet
55PubMed
56QIAGEN
61SNOMED-CT via Orphanet
65Tumor Gene Family of Databases
66UMLS
67UMLS via Orphanet