MCID: ADL030
MIFTS: 53

Adult-Onset Still's Disease malady

Rare diseases, Nephrological diseases, Bone diseases categories

Aliases & Classifications for Adult-Onset Still's Disease

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Sources:
65UMLS, 51Orphanet, 10Disease Ontology, 45NIH Rare Diseases, 12DISEASES, 47Novoseek, 36MeSH, 59SNOMED-CT, 28ICD10 via Orphanet, 37MESH via Orphanet, 66UMLS via Orphanet, 27ICD10
See all sources

Aliases & Descriptions for Adult-Onset Still's Disease:

Name: Adult-Onset Still's Disease 10 45 12
Adult-Onset Still Disease 10 51 65
Still's Disease, Adult-Onset 36
Adult Onset Still's Disease 10
Still's Disease Adult Onset 45
 
Stills Disease Adult-Onset 47
Wissler-Fanconi Syndrome 51
Adult Still's Disease 45
Wissler's Syndrome 65
Aosd 51


Classifications:



Characteristics (Orphanet epidemiological data):

51
adult-onset still disease:
Inheritance: Not applicable; Prevalence: 1-9/100000 (Worldwide),1-9/1000000 (France),1-9/1000000 (Japan),1-9/1000000 (Norway),1-9/100000 (Norway),1-9/100000 (Europe); Age of onset: Adult; Age of death: normal life expectancy


External Ids:

Disease Ontology10 DOID:14256
MeSH36 D016706
Orphanet51 829
ICD10 via Orphanet28 M06.1
MESH via Orphanet37 D014924, D016706
UMLS via Orphanet66 C0043195, C0085253
ICD1027 M06.1

Summaries for Adult-Onset Still's Disease

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NIH Rare Diseases:45 Adult-onset still's disease is an inflammatory condition characterized by high fevers, rash, sore throat, and joint pain. as it progresses, adult-onset still's disease may lead to chronic arthritis and other complications. still's disease was named after an english doctor named george still, who described the condition in children in 1896. still's disease which occurs in children (those under the age of 16) is now known as systemic onset juvenile rheumatoid arthritis (jra). in 1971, the term "adult still's disease" was used to describe adults who had a condition similar to systemic onset jra. the cause of adult-onset still's disease is unknown. no risk factors for the disease have been identified. there's no cure for adult-onset still's disease; however, treatment may offer symptom relief and help prevent complications.  last updated: 5/28/2014

MalaCards based summary: Adult-Onset Still's Disease, also known as adult-onset still disease, is related to wissler's syndrome and fanconi syndrome, and has symptoms including skin rash, pruritus and urticaria. An important gene associated with Adult-Onset Still's Disease is IL18 (Interleukin 18), and among its related pathways are Hypertrophy Model and Immune response_MIF-mediated glucocorticoid regulation. Affiliated tissues include bone, liver and bone marrow, and related mouse phenotypes are adipose tissue and muscle.

Disease Ontology:10 An arthritis that is a rare from of inflammatory arthritis characterized by fevers, rash, and joint pain.

Related Diseases for Adult-Onset Still's Disease

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Diseases related to Adult-Onset Still's Disease via text searches within MalaCards or GeneCards Suite gene sharing:

(show top 50)    (show all 235)
idRelated DiseaseScoreTop Affiliating Genes
1wissler's syndrome30.3CRP, IL1B, IL6, TNF
2fanconi syndrome10.3
3hepatitis10.3
4cold urticaria10.3CRP, IL6
5dural sinus malformation10.2CRP, IL6
6clear cell acanthoma10.2CRP, IL6
7best1 retinopathy10.2IL18, TNF
8catamenial pneumothorax10.2CRP, IL6
9congenital chloride diarrhea10.2CRP, IL6
10cerebellar astrocytoma10.2CRP, IL6
11intestinal impaction10.2CRP, IL6
12intermediate malignant teratoma10.2CRP, IL6
13microcystic adenoma10.2IL18, TNF
14chronic gonorrhea of cervix10.2CRP, TNF
15brucella suis brucellosis10.2CRP, IL6
16akinetopsia10.2CRP, IL6
17cell type benign neoplasm10.2CRP, IL6
18multicentric osteolysis nephropathy10.2CRP, IL6
19breast epithelioid hemangioma10.2IL18, IL6
20anterior cerebral artery infarction10.2CRP, IL6
21hereditary night blindness10.2CRP, IL6
22crohn's disease10.2IL6, TNF
23optic nerve sheath meningioma10.2IL1R1, IL6
24aorta atresia10.2IL6, TNF
25drug dependence10.2CRP, TNF
26malignant sertoli-leydig cell tumor of ovary10.2IL6, TNF
27hyper-igd syndrome10.2CRP, IL1RN
28glycogen storage disease viii10.2IL6, TNF
29cataract10.2CRP, IL1RN
30central neurocytoma10.2CRP, TNF
31anti-hla hyperimmunization10.2IL6, TNF
32posterior valve urethra10.2IL6, TNF
33treponema infection10.2IL6, TNF
34gemistocytic astrocytoma10.2CRP, IL6
35testicular leukemia10.2IL6, TNF
36lower lip cancer10.2IL18, TNF
37echinostomiasis10.2IL6, TNF
38fibrogenesis imperfecta ossium10.2IL18, TNF
39bacteremia10.2CRP, TNF
40extrahepatic bile duct papillary adenoma10.2CRP, IL6
41benign lymphoepithelial lesion of salivary gland10.2IL6, TNF
42polyglucosan body disease, adult form10.2CRP, IL1RN
43hemorrhagic proctocolitis10.2IL6, TNF
44pyrimidine metabolic disorder10.2IL1R1, TNF
45neonatal adrenoleukodystrophy10.1IL1R1, IL1RN
46gallbladder papillomatosis10.1CRP, TNF
47acute disseminated encephalomyelitis10.1CRP, IL18, IL6
48diabetic ketoacidosis10.1IL1B, IL6
49polyclonal hypergammaglobulinemia10.1CRP, IL1B
50arthritis10.1

Graphical network of the top 20 diseases related to Adult-Onset Still's Disease:



Diseases related to adult-onset still's disease

Symptoms for Adult-Onset Still's Disease

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Symptoms:

 51 (show all 26)
  • cutaneous rash
  • urticaria
  • pruritus/itching
  • hepatomegaly/liver enlargement (excluding storage disease)
  • splenomegaly
  • interstitial/restrictive pneumopathy/restrictive respiratory syndrome
  • articular/joint pain/arthralgia
  • hydrarthrosis/articular/joint effusion
  • arthritis/synovitis/synovial proliferation
  • hyperleukocytosis/leukocytosis
  • fever/chilling
  • asthenia/fatigue/weakness
  • biological inflammatory syndrome/increased erythrocyte sedimentation rate/crp
  • acute abdominal pain/colic
  • abnormal pleura/hydrothorax/pleuresia/pleural effusion/chylothorax
  • mediastinal/hilar adenopathies
  • pericardium anomalies/pericarditis/absence/cysts/pericardial effusion
  • myalgia/muscular pain
  • pharyngitis
  • hepatitis/icterus/cholestasis
  • abnormal hepatic enzymes/transaminases
  • myocardium anomalies/myocarditis
  • meningitis/meningeal syndrome
  • cartilage destruction/chondrolysis
  • bone marrow failure/pancytopenia
  • hyperlipidemia/hypercholesterolemia/hypertriglyceridemia

HPO human phenotypes related to Adult-Onset Still's Disease:

(show all 23)
id Description Frequency HPO Source Accession
1 skin rash hallmark (90%) HP:0000988
2 pruritus hallmark (90%) HP:0000989
3 urticaria hallmark (90%) HP:0001025
4 arthritis hallmark (90%) HP:0001369
5 joint swelling hallmark (90%) HP:0001386
6 splenomegaly hallmark (90%) HP:0001744
7 leukocytosis hallmark (90%) HP:0001974
8 restrictive lung disease hallmark (90%) HP:0002091
9 hepatomegaly hallmark (90%) HP:0002240
10 arthralgia hallmark (90%) HP:0002829
11 abnormality of temperature regulation hallmark (90%) HP:0004370
12 abnormality of the pericardium typical (50%) HP:0001697
13 abdominal pain typical (50%) HP:0002027
14 abnormality of the pleura typical (50%) HP:0002103
15 myalgia typical (50%) HP:0003326
16 mediastinal lymphadenopathy typical (50%) HP:0100721
17 meningitis occasional (7.5%) HP:0001287
18 abnormality of the myocardium occasional (7.5%) HP:0001637
19 elevated hepatic transaminases occasional (7.5%) HP:0002910
20 abnormality of lipid metabolism occasional (7.5%) HP:0003119
21 bone marrow hypocellularity occasional (7.5%) HP:0005528
22 cartilage destruction occasional (7.5%) HP:0100773
23 recurrent pharyngitis occasional (7.5%) HP:0100776

Drugs & Therapeutics for Adult-Onset Still's Disease

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Drugs for Adult-Onset Still's Disease (from DrugBank, HMDB, Dgidb, PharmGKB, IUPHAR, NovoSeek, BitterDB):

(show all 9)
idNameStatusPhaseClinical TrialsCas NumberPubChem Id
1
PrednisoloneapprovedPhase 2103350-24-85755
Synonyms:
(11beta)-11,17,21-Trihydroxypregna-1,4-diene-3,20-dione
.DELTA.1-Cortisol
.DELTA.1-Dehydrocortisol
.DELTA.1-Dehydrohydrocortisone
.DELTA.1-Hydrocortisone
.delta.-Cortef
.delta.-Stab
1,2-Dehydrohydrocortisone
1,4-Pregnadiene-11beta,17alpha,21-triol-3,20-dione
1,4-Pregnadiene-3,20-dione-11beta,17alpha,21-triol
1-Dehydrocortisol
1-Dehydrohydrocortisone
3,20-dioxo-11beta,17alpha,21-Trihydroxy-1,4-pregnadiene
46656_FLUKA
46656_RIEDEL
50-24-8
58201-11-9
8056-11-9
AC-1773
AC1L1L2E
Ak-Pred
Ak-Tate
Alphadrol
Articulose-50
BPBio1_000164
BRD-K98039984-001-03-0
BRN 1354103
BSPBio_000148
Bio-0666
Bubbli-Pred
C07369
CCRIS 980
CHEBI:8378
CHEMBL131
CID5755
CO-Hydeltra
CPD000718761
Co-Hydeltra
Codelcortone
Cordrol
Cortalone
Cotogesic
Cotolone
D00472
D011239
DB00860
Decaprednil
Decortin H
Delcortol
Delta F
Delta(1)-dehydrohydrocortisone
Delta-Cortef
Delta-Cortef (TN)
Delta-Ef-Cortelan
Delta-Stab
Delta-stab
Deltacortenol
Deltacortril
Deltacortril Enteric
Deltahydrocortisone
Deltasolone
Deltisilone
Depo-Medrol
Derpo PD
Derpo Pd
Dexa-Cortidelt Hostacortin H
Dexa-Cortidelt hostacortin H
Di Adreson F
Di-Adreson F
Di-Adreson-F
Di-adreson F
DiAdresonF
Dicortol
Donisolone
Dydeltrone
EINECS 200-021-7
Eazolin D
Econopred
Econopred Plus
Erbacort
Erbasona
Estilsona
Fernisolone
Fernisolone P
Fernisolone-P
Flamasone
Flo-pred
HMS1568H10
HMS2090J05
HSDB 3385
Hostacortin H
Hydeltra
Hydeltra-Tba
Hydeltrasol
Hydeltrone
Hydrodeltalone
Hydrodeltisone
Hydroretrocortin
Hydroretrocortine
I-Pred
Inflamase Forte
Inflamase Mild
K 1557
Key-Pred
Klismacort
LMST02030179
LS-7669
Lentosone
Lite Pred
M-Predrol
MLS001304083
 
MLS002154250
MLS002207037
Medrol
Medrol Acetate
Metacortandralone
Methylprednisolone Acetate
Meti-Derm
Meticortelone
Metreton
Millipred
MolPort-002-507-147
NCGC00179649-01
NSC 9120
NSC9120
NSC9900
Neo-Delta-Cortef
Nisolone
Nor-Pred T.B.A.
Ocu-Pred
Ocu-Pred Forte
Omnipred
Ophtho-Tate
Orapred
P0152_SIGMA
P0637
P6004_SIGMA
PRDL
PRED-G
Panafcortelone
Paracortol
Paracotol
Pediapred
Poly-Pred
Precortalon
Precortancyl
Precortilon
Precortisyl
Pred Forte
Pred Mild
Predair
Predair A
Predair Forte
Predalone 50
Predalone T.B.A.
Predate
Predate Tba
Predate-50
Predcor-25
Predcor-50
Predcor-Tba
Predisolone Sodium Phosphate
Predne-Dome
Prednelan
Predni-Dome
Prednicen
Predniliderm
Predniretard
Prednis
Prednisolona
Prednisolona [INN-Spanish]
Prednisolone
Prednisolone (JP15/USP/INN)
Prednisolone (anhydrous)
Prednisolone Acetate
Prednisolone Sodium Phosphate
Prednisolone Tebutate
Prednisolone [INN:BAN:JAN]
Prednisolonum
Prednisolonum [INN-Latin]
Predonin
Predonine
Prelone
Prenolone
Prestwick0_000274
Prestwick1_000274
Prestwick2_000274
Prestwick3_000274
Prestwick_404
Rolisone
S1737_Selleck
SAM002264639
SMR000718761
SPBio_002367
Scherisolon
Solone
Steran
Sterane
Sterolone
Supercortisol
UNII-9PHQ9Y1OLM
Ulacort
Ultra Pred
Ultracorten H
Ultracortene H
Ultracortene-H
Ultracortene-Hydrogen
Ultracortene-hydrogen
ZINC03833821
component of Ataraxoid
component of K-Predne-Dome
delta(1)-Cortisol
delta(1)-Dehydrocortisol
delta(1)-Dehydrohydrocortisone
delta(1)-Hydrocortisone
delta(sup 1)-Cortisol
delta(sup 1)-Dehydrocortisol
delta(sup 1)-Dehydrohydrocortisone
delta(sup 1)-Hydrocortisone
delta-dehydrocortisol
delta-dehydrohydrocortisone
delta-hydrocortisone
prednisolone
2
MethylprednisoloneapprovedPhase 2103383-43-26741
Synonyms:
(6S,8S,9S,10R,11S,13S,14S,17R)-11,17-dihydroxy-17-(2-hydroxyacetyl)-6,10,13-trimethyl-7,8,9,11,12,14,15,16-octahydro-6H-cyclopenta[a]phenanthren-3-one
(6a,11b)-11,17,21-Trihydroxy-6-methylpregna-1,4-diene-3,20-dione
(6alpha,11beta)-11,17,21-Trihydroxy-6-methylpregna-1,4-diene-3,20-dione
(6α,11β)-11,17,21-trihydroxy-6-methylpregna-1,4-diene-3,20-dione
.DELTA.1-6.alpha.-Methylhydrocortisone
1-Dehydro-6alpha-methylhydrocortisone
1-dehydro-6alpha-Methylhydrocortisone
1-dehydro-6α-methylhydrocortisone
11-beta,17,21-Trihydroxy-6-alpha-methylpregna-1,4-diene-3,20-dione
11beta,17,21-Trihydroxy-6alpha-methylpregna-1,4-diene-3,20-dione
11beta,17alpha,21-Trihydroxy-6alpha-methyl-1,4-pregnadiene-3,20-dione
11beta,17alpha,21-Trihydroxy-6alpha-methylpregna-1,4-diene-3,20-dione
121673-01-6
4-08-00-03498 (Beilstein Handbook Reference)
46436_FLUKA
46436_RIEDEL
570-35-4
6 Methylprednisolone
6-Methylprednisolone
6-alpha-Methylprednisolone
6.alpha.-Methylprednisolone
6923-42-8
6alpha-Methyl-11beta,17alpha,21-trihydroxy-1,4-pregnadiene-3,20-dione
6alpha-Methyl-11beta,17alpha,21-triol-1,4-pregnadiene-3,20-dione
6alpha-Methylprednisolone
6alpha-methyl-11beta,17alpha,21-triol-1,4-pregnadiene-3,20-dione
83-43-2
A-methapred
AC1L1N7A
Artisone-Wyeth
Artisone-wyeth
BPBio1_000174
BRD-K35240538-001-03-1
BRN 2340300
BSPBio_000158
Besonia
Bio-0658
CHEBI:6888
CHEMBL650
CID6741
CPD000058330
D00407
D008775
DB00959
Depo-Medrol (acetate)
Depo-medrol
Dopomedrol
EINECS 201-476-4
Esametone
Firmacort
HMS1568H20
HMS2090B13
HSDB 3127
LMST02030178
LS-118498
Lemod
M0639_SIGMA
M1665
MEPRDL
MLS000028541
MLS001148159
MLS002207191
Medesone
Medixon
Medlone 21
 
Medrate
Medrol
Medrol (TN)
Medrol Adt Pak
Medrol Dosepak
Medrol adt pak
Medrol dosepak
Medrol, Solu-Medrol, Medrone, Methylprednisolone
Medrone
Mesopren
Metastab
Methyleneprednisolone
Methylprednisolon
Methylprednisolone
Methylprednisolone (JP15/USP/INN)
Methylprednisolone [USAN:INN:BAN:JAN]
Methylprednisolone, 6-alpha
Methylprednisolonum
Methylprednisolonum [INN-Latin]
Metilbetasone
Metilprednisolona
Metilprednisolona [INN-Spanish]
Metilprednisolone
Metilprednisolone [DCIT]
Metilprednisolone [Dcit]
Metipred
Metrisone
Metrocort
Metysolon
Moderin
MolPort-002-528-554
NCGC00022735-03
NCI60_001657
NSC-19987
NSC19987
Nirypan
Noretona
Predni N Tablinen
Prednol- L
Pregna-1,4-diene-3,20-dione, 11beta,17,21-trihydroxy-6alpha-methyl- (8CI)
Prestwick0_000279
Prestwick1_000279
Prestwick2_000279
Prestwick3_000279
Prestwick_622
Promacortine
Reactenol
S1733_Selleck
SAM002589984
SMR000058330
SPBio_002377
Sieropresol
Solomet
Solu-medrol
Summicort
Suprametil
U 7532
UNII-X4W7ZR7023
Urbason
Urbasone
Wyacort
ZINC03875560
delta(1)-6alpha-Methylhydrocortisone
delta(sup 1)-6-alpha-Methylhydrocortisone
methylprednisolone
methylprenisolone
3
MethotrexateapprovedPhase 213871959-05-2, 59-05-2126941
Synonyms:
4-amino-10-methylfolic acid
4-amino-N(10)-Methylpteroylglutamic acid
Abitrexate
Amethopterin
Amethopterine
Antifolan
Arbitrexate
Emtexate
Folex
HDMTX
L-Amethopterin
Ledertrexate
MTX
Metatrexan
Methopterin
Methotextrate
 
Methotrate
Methotrexat
Methotrexate
Methotrexate Sodium
Methotrexatum
Methylaminopterin
Methylaminopterinum
Metoject
Metotrexato
Mexate
Méthotrexate
N-Bismethylpteroylglutamic Acid
N-[4-[[(2,4-Diamino-6-pteridinyl)methyl]methylamino]benzoyl]-L-glutamic acid
Otrexup
Rasuvo
Rheumatrex
Rheumatrex Dose Pack
Trexall
4Prednisolone hemisuccinatePhase 21033
5Prednisolone phosphatePhase 21033
6Prednisolone acetatePhase 21033
7Methylprednisolone HemisuccinatePhase 21033
8Methylprednisolone acetatePhase 21033
9Interleukin 1 Receptor Antagonist ProteinPhase 235

Interventional clinical trials:

idNameStatusNCT IDPhase
1Interleukin-1 Trap to Treat Autoinflammatory DiseasesCompletedNCT00094900Phase 2
2Canakinumab for Treatment of Adult Onset Still's DiseaseRecruitingNCT02204293Phase 2
3Therapeutic Use of Tadekinig Alfa in Adult-onset Still's DiseaseRecruitingNCT02398435Phase 2
4Treatment of Refractory Adult-onset Still's Disease With Anakinra: a Randomized StudyActive, not recruitingNCT01033656Phase 2
5Efficacy and Safety of Tocilizumab in Adult's Still DiseaseNot yet recruitingNCT01002781Phase 2
6Glycosylated Ferritin in Macrophagic Activation SyndromesRecruitingNCT02143986

Search NIH Clinical Center for Adult-Onset Still's Disease


Cochrane evidence based reviews: Still's Disease, Adult-Onset

Genetic Tests for Adult-Onset Still's Disease

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Anatomical Context for Adult-Onset Still's Disease

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MalaCards organs/tissues related to Adult-Onset Still's Disease:

33
Bone, Liver, Bone marrow, Skin, Lung, T cells, Lymph node

Animal Models for Adult-Onset Still's Disease or affiliated genes

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MGI Mouse Phenotypes related to Adult-Onset Still's Disease:

38 (show all 13)
idDescriptionMGI Source AccessionScoreTop Affiliating Genes
1MP:00053759.2IL18, IL1R1, IL6, TNF
2MP:00053698.5CSF1, IL18, IL1R1, IL6, TNF
3MP:00053918.4CSF1, IL18, IL1R1, IL6, TNF
4MP:00053708.1CSF1, IL1R1, IL6, MEFV, TNF
5MP:00053847.4CSF1, IL18, IL1R1, IL1RN, IL6, MEFV
6MP:00053787.2CSF1, IL18, IL1R1, IL1RN, IL6, MEFV
7MP:00053907.2CSF1, IL1B, IL1R1, IL1RN, IL6, MEFV
8MP:00053857.1CRP, CSF1, IL18, IL1B, IL1R1, IL1RN
9MP:00107717.0CSF1, IL18, IL1R1, IL1RN, IL6, MEFV
10MP:00107686.6CSF1, IL18, IL1B, IL1R1, IL1RN, IL6
11MP:00053976.4CSF1, IL18, IL1B, IL1R1, IL1RN, IL6
12MP:00053766.0CRP, CSF1, IL18, IL1B, IL1R1, IL1RN
13MP:00053875.8CRP, CSF1, IL18, IL1B, IL1R1, IL1RN

Publications for Adult-Onset Still's Disease

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Articles related to Adult-Onset Still's Disease:

(show top 50)    (show all 544)
idTitleAuthorsYear
1
A Case of Adult-Onset Still's Disease Treated with Monitoring of Serum Tacrolimus Levels. (26535602)
2015
2
Therapeutic Efficacy of Leukocytapheresis in a Pregnant Woman with Refractory Adult-onset Still's Disease. (26328658)
2015
3
The CD68+/H-ferritin+ cells colonize the lymph nodes of the patients with Adult onset Still's disease and are associated with increased extracellular level of H-ferritin in the same tissue. Correlation with disease severity and implication for pathogenesis. (26540556)
2015
4
Adult onset Still's disease (AOSD) in the era of biologic therapies: Dichotomous view for cytokine and clinical expressions. (25183244)
2014
5
Tocilizumab for the treatment of adult-onset Still's disease: results from a case series. (24005839)
2014
6
Pathogenesis of adult-onset Still's disease: new insights from the juvenile counterpart. (25388963)
2014
7
Acalculous cholecystitis with multiple organ failure and disseminated intravascular coagulation in a patient with adult onset Still's disease. (24975054)
2014
8
MEFV gene mutations and their clinical significance in Korean patients with adult-onset Still's disease. (24064016)
2013
9
A case of adult-onset Still's disease complicated by hemophagocytic syndrome and interstitial pneumonia with pneumomediastinum/recurrent pneumothorax. (22898226)
2012
10
Mycoplasma pneumoniae infection associated with urticarial vasculitis mimicking adult-onset Still's disease. (21918897)
2012
11
Biological treatment in adult-onset Still's disease. (23040362)
2012
12
A case of refractory adult-onset Still's disease with high serum interleukin-18 levels treated with monitoring of serum levels of cyclosporine. (22423500)
2012
13
Retrospective study of 61 patients with adult-onset Still's disease admitted with fever of unknown origin in China. (21773715)
2012
14
Aseptic meningitis in adult onset Still's disease. (20495923)
2012
15
Adult-onset Still's disease complicated by autoimmune hepatitis: successful treatment with infliximab. (22576401)
2012
16
Adult-onset Still's disease misdiagnosed as pneumonia: two case reports. (22472935)
2011
17
Adult onset still's disease with autoimmune haemolytic anaemia: two rarities in combination. (22355977)
2011
18
Hidden in plain sight: macrophage activation syndrome complicating Adult Onset Still's Disease. (23875527)
2010
19
Clinical manifestations but not cytokine profiles differentiate adult-onset Still's disease and sepsis. (20810496)
2010
20
Adult-Onset Still's Disease and cytomegalovirus infection. (20711100)
2010
21
A case of adult-onset Still's disease complicated with diffuse alveolar hemorrhage. (19270830)
2009
22
Clinical features and prognosis of adult-onset still's disease: 61 cases from China. (19273456)
2009
23
Multicentric Castleman's disease mimicking adult-onset Still's disease. (19213588)
2009
24
Association of Fcgamma receptor polymorphisms with adult onset Still's disease in Korea. (19040302)
2009
25
Adult-onset Still's disease, Schnitzler syndrome, and autoinflammatory syndromes in adulthood]. (19838717)
2009
26
Continuation of anakinra despite the development of a pruritic rash in an otherwise refractory case of adult-onset Still's disease. (19213754)
2009
27
Richter's syndrome developing in a patient with adult onset Still's disease. (18607590)
2009
28
Potential benefit of paracetamol administration in adult-onset Still's disease. (19776706)
2009
29
Etanercept as a rescue agent in patient with adult onset Still's disease complicated with congestive heart failure. (18500457)
2008
30
Anakinra in patients with treatment-resistant adult-onset Still's disease: four case reports with serial cytokine measurements and a review of the literature. (17583775)
2007
31
Adult-onset Still's disease: can recent advances in our understanding of its pathogenesis lead to targeted therapy? (17538564)
2007
32
Hemophagocytic syndrome in one patient with adult-onset Still's disease. Presentation with febrile neutropenia. (16550302)
2007
33
Celiac disease: association with adult-onset Still's disease: apropos of a clinical case. (17611347)
2007
34
Ten years of clinical experience with adult onset Still's disease: is the outcome improving? (17086384)
2007
35
Interleukin-1beta and interleukin-1 receptor antagonist gene polymorphisms in Korean patients with adult-onset Still's disease. (17963170)
2007
36
Adult-onset Still's disease with persistent skin eruption and fatal respiratory failure in a Taiwanese woman. (17101495)
2006
37
Diagnosis and management of adult onset Still's disease. (16219707)
2006
38
Cytomegalovirus-associated hemophagocytic syndrome in a patient with adult onset Still's disease. (15789896)
2005
39
Two cases of acute respiratory distress syndrome resulting from adult-onset Still's disease. (24387121)
2003
40
Humanized monoclonal anti-interleukin-6 receptor antibody for treatment of intractable adult-onset Still's disease. (12483747)
2002
41
Hepatitis A infection mimicking adult onset Still's disease. (10914871)
2000
42
Adult onset Still's disease presenting as aseptic meningitis in a young healthy female. (10363409)
1999
43
Adult-onset Still's disease in an oriental population: manifestations, course and outcome in 16 patients. (9588268)
1998
44
Schnitzler's syndrome versus adult onset Still's disease. (9649652)
1998
45
Adult onset Still's disease. 16 cases. (7567848)
1995
46
Osseous tuberculosis traced by magnetic resonance imaging in a patient with adult-onset Still's disease. (8508290)
1993
47
Adult onset Still's disease and related renal amyloidosis. (2029209)
1991
48
Sensorineural hearing loss in adult onset Still's disease. (3401057)
1988
49
Adult-onset Still's disease: a case with onset during pregnancy. (4026893)
1985
50
Adult-onset Still's disease with an associated severe restrictive pulmonary defect: a case report. (6882042)
1983

Variations for Adult-Onset Still's Disease

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Expression for genes affiliated with Adult-Onset Still's Disease

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Search GEO for disease gene expression data for Adult-Onset Still's Disease.

Pathways for genes affiliated with Adult-Onset Still's Disease

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Pathways related to Adult-Onset Still's Disease according to GeneCards Suite gene sharing:

(show all 44)
idSuper pathways (with members indented)ScoreTop Affiliating Genes
19.7IL18, IL1R1
29.6IL6, TNF
39.5IL18, IL1B
49.5IL1B, IL6
5
Salmonella infection (KEGG)
Show member pathways
9.2IL1B, IL6
6
Show member pathways
9.1IL18, IL1B, IL1R1
7
Show member pathways
9.0IL1B, IL1R1, IL6
89.0IL18, IL1B, TNF
9
Show member pathways
9.0IL1B, IL1R1, IL1RN
109.0IL1B, IL6, TNF
119.0IL1B, IL6, TNF
129.0IL1B, IL6, TNF
138.9IL1B, IL1R1, TNF
14
Apoptosis (KEGG)
Show member pathways
8.9IL1B, IL1R1, TNF
15
Show member pathways
8.9IL1B, IL1R1, TNF
168.8CSF1, IL1B, TNF
17
Show member pathways
8.6IL18, IL1B, IL6, TNF
18
Show member pathways
8.6IL18, IL1B, IL6, TNF
19
Show member pathways
8.6IL18, IL1B, IL6, TNF
208.6IL18, IL1B, IL6, TNF
21
Show member pathways
8.6IL18, IL1B, IL6, TNF
228.6IL18, IL1B, IL6, TNF
238.6IL18, IL1B, IL6, TNF
248.6IL18, IL1B, IL6, TNF
25
Show member pathways
8.6IL18, IL1B, IL6, TNF
26
Show member pathways
8.6CRP, IL1B, IL6, TNF
278.5IL1B, IL1RN, IL6, TNF
28
Show member pathways
8.5IL1B, IL1R1, IL6, TNF
298.5IL1B, IL1R1, IL6, TNF
30
Show member pathways
8.5IL1B, IL1R1, IL6, TNF
318.5IL1B, IL1R1, IL6, TNF
32
Show member pathways
8.5IL1B, IL1R1, IL6, TNF
338.5CSF1, IL18, IL1B, TNF
348.4CSF1, IL1B, IL6, TNF
358.4CSF1, IL1B, IL6, TNF
368.4CSF1, IL1B, IL1R1, TNF
378.1CSF1, IL18, IL1B, IL6, TNF
388.0CSF1, IL1B, IL1R1, IL6, TNF
39
Show member pathways
7.8IL18, IL1B, IL6, MEFV, TNF
40
Show member pathways
7.8IL18, IL1B, IL1R1, IL1RN, IL6, TNF
41
Show member pathways
7.7CSF1, IL18, IL1B, IL1R1, IL6, TNF
42
Show member pathways
7.7CSF1, IL18, IL1B, IL1R1, IL6, TNF
43
Show member pathways
7.7CSF1, IL18, IL1B, IL1R1, IL6, TNF
44
Show member pathways
6.6CRP, IL18, IL1B, IL1R1, IL1RN, IL6

GO Terms for genes affiliated with Adult-Onset Still's Disease

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Cellular components related to Adult-Onset Still's Disease according to GeneCards Suite gene sharing:

idNameGO IDScoreTop Affiliating Genes
1extracellular regionGO:00055767.6CRP, IL18, IL1B, IL1RN, IL6, TNF
2extracellular spaceGO:00056156.9CRP, CSF1, IL18, IL1B, IL1R1, IL1RN

Biological processes related to Adult-Onset Still's Disease according to GeneCards Suite gene sharing:

(show all 47)
idNameGO IDScoreTop Affiliating Genes
1epithelial cell proliferation involved in salivary gland morphogenesisGO:006066410.3IL6, TNF
2positive regulation of tyrosine phosphorylation of Stat3 proteinGO:004251710.2IL18, IL6
3positive regulation of chemokine productionGO:003272210.2IL6, TNF
4positive regulation of granulocyte macrophage colony-stimulating factor productionGO:003272510.2IL18, IL1B
5inflammatory response to antigenic stimulusGO:000243710.1IL1B, IL1RN
6fever generationGO:000166010.1IL1B, IL1RN
7ovulationGO:003072810.1IL1B, IL1R1
8negative regulation of glutamate secretionGO:001405010.1IL1B, IL1RN
9negative regulation of myoblast differentiationGO:004566210.1IL18, TNF
10sequestering of triglycerideGO:003073010.0IL1B, TNF
11positive regulation of calcidiol 1-monooxygenase activityGO:006055910.0IL1B, TNF
12regulation of establishment of endothelial barrierGO:190314010.0IL1B, TNF
13positive regulation of chemokine biosynthetic processGO:004508010.0IL1B, TNF
14positive regulation of membrane protein ectodomain proteolysisGO:005104410.0IL1B, TNF
15negative regulation of lipid catabolic processGO:00509959.9IL1B, TNF
16positive regulation of heterotypic cell-cell adhesionGO:00341169.9IL1B, TNF
17positive regulation of fever generationGO:00316229.9IL1B, TNF
18response to interleukin-1GO:00705559.9IL1R1, IL1RN
19negative regulation of lipid storageGO:00108889.9CRP, IL6, TNF
20protein kinase B signalingGO:00434919.9IL1B, TNF
21acute-phase responseGO:00069539.9CRP, IL1RN, IL6
22osteoclast differentiationGO:00303169.9CSF1, TNF
23positive regulation of interleukin-8 productionGO:00327579.9IL1B, TNF
24positive regulation of osteoclast differentiationGO:00456729.9CSF1, TNF
25regulation of I-kappaB kinase/NF-kappaB signalingGO:00431229.8IL1B, TNF
26response to organonitrogen compoundGO:00102439.8IL1B, IL1RN
27positive regulation of phagocytosisGO:00507669.6IL1B, TNF
28positive regulation of interferon-gamma productionGO:00327299.6IL18, IL1B, TNF
29positive regulation of NF-kappaB import into nucleusGO:00423469.6IL18, IL1B, TNF
30chronic inflammatory response to antigenic stimulusGO:00024399.6IL1B, IL1RN, TNF
31lipopolysaccharide-mediated signaling pathwayGO:00316639.6IL18, IL1B, TNF
32positive regulation of JUN kinase activityGO:00435079.5IL1B, IL1RN, TNF
33positive regulation of sequence-specific DNA binding transcription factor activityGO:00510919.5IL1B, IL6, TNF
34response to organic cyclic compoundGO:00140709.5IL1B, IL1RN, IL6
35response to lipopolysaccharideGO:00324969.4IL1B, IL1RN, IL6
36positive regulation of NF-kappaB transcription factor activityGO:00510929.4IL1B, IL6, TNF
37defense response to Gram-positive bacteriumGO:00508309.4CRP, IL6, TNF
38negative regulation of extrinsic apoptotic signaling pathway in absence of ligandGO:20012409.3IL1B, TNF
39cellular response to organic cyclic compoundGO:00714079.3IL18, IL1B, TNF
40positive regulation of interleukin-6 productionGO:00327559.3IL1B, IL6, TNF
41positive regulation of nitric oxide biosynthetic processGO:00454299.0IL1B, IL6, TNF
42response to glucocorticoidGO:00513849.0IL1B, IL1RN, IL6, TNF
43cellular response to lipopolysaccharideGO:00712229.0IL18, IL1B, IL6, TNF
44positive regulation of ERK1 and ERK2 cascadeGO:00703748.9IL1B, IL6, TNF
45immune responseGO:00069558.0IL18, IL1B, IL1R1, IL1RN, IL6, TNF
46positive regulation of gene expressionGO:00106287.5CRP, CSF1, IL18, IL1B, IL6, TNF
47inflammatory responseGO:00069547.2CRP, CSF1, IL18, IL1B, IL6, MEFV

Molecular functions related to Adult-Onset Still's Disease according to GeneCards Suite gene sharing:

idNameGO IDScoreTop Affiliating Genes
1interleukin-1 receptor bindingGO:00051499.8IL1B, IL1RN
2cytokine activityGO:00051257.7CSF1, IL18, IL1B, IL1RN, IL6, TNF

Sources for Adult-Onset Still's Disease

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2CDC
14ExPASy
15FDA
16FMA
24GTR
25HGMD
26HMDB
27ICD10
28ICD10 via Orphanet
29ICD9CM
30IUPHAR
31KEGG
34MedGen
36MeSH
37MESH via Orphanet
38MGI
41NCI
42NCIt
43NDF-RT
46NINDS
47Novoseek
49OMIM
50OMIM via Orphanet
54PubMed
55QIAGEN
60SNOMED-CT via Orphanet
64Tumor Gene Family of Databases
65UMLS
66UMLS via Orphanet