MCID: ADL030
MIFTS: 65

Adult-Onset Still's Disease

Categories: Rare diseases, Nephrological diseases, Bone diseases

Aliases & Classifications for Adult-Onset Still's Disease

MalaCards integrated aliases for Adult-Onset Still's Disease:

Name: Adult-Onset Still's Disease 12 72 49 14
Adult-Onset Still Disease 12 55 69
Adult Onset Still's Disease 12 36
Still's Disease, Adult-Onset 41
Still's Disease Adult Onset 49
Stills Disease Adult-Onset 51
Wissler-Fanconi Syndrome 55
Adult Still's Disease 49
Wissler's Syndrome 69
Aosd 55

Characteristics:

Orphanet epidemiological data:

55
adult-onset still disease
Inheritance: Not applicable; Prevalence: 1-9/1000000 (France),1-9/1000000 (Japan),1-9/1000000 (Norway),1-9/100000 (Norway),1-9/100000 (Europe),1-9/1000000 (Turkey),1-9/100000 (Turkey); Age of onset: Adult; Age of death: normal life expectancy;

Classifications:



Summaries for Adult-Onset Still's Disease

NIH Rare Diseases : 49 Adult-onset Still's disease is an inflammatory condition characterized by high fevers, rash, sore throat, and joint pain. As it progresses, adult-onset Still's disease may lead to chronic arthritis and other complications. Still's disease was named after an English doctor named George Still, who described the condition in children in 1896. Still's disease which occurs in children (those under the age of 16) is now known as systemic onset juvenile rheumatoid arthritis (JRA). In 1971, the term "adult Still's disease" was used to describe adults who had a condition similar to systemic onset JRA. The cause of adult-onset Still's disease is unknown. No risk factors for the disease have been identified. There's no cure for adult-onset Still's disease; however, treatment may offer symptom relief and help prevent complications.  Last updated: 5/28/2014

MalaCards based summary : Adult-Onset Still's Disease, also known as adult-onset still disease, is related to cellulitis and rheumatoid arthritis, systemic juvenile, and has symptoms including skin rash, pruritus and meningitis. An important gene associated with Adult-Onset Still's Disease is IL18 (Interleukin 18), and among its related pathways/superpathways are Innate Immune System and PEDF Induced Signaling. The drugs Antirheumatic Agents and Interleukin 1 Receptor Antagonist Protein have been mentioned in the context of this disorder. Affiliated tissues include liver, bone and skin, and related phenotypes are hematopoietic system and cardiovascular system

Disease Ontology : 12 An arthritis that is a rare from of inflammatory arthritis characterized by fevers, rash, and joint pain.

Wikipedia : 72 Adult-onset Still\'s disease (AOSD) is a form of Still\'s disease, a rare systemic autoinflammatory... more...

Related Diseases for Adult-Onset Still's Disease

Diseases related to Adult-Onset Still's Disease via text searches within MalaCards or GeneCards Suite gene sharing:

(show top 50) (show all 275)
# Related Disease Score Top Affiliating Genes
1 cellulitis 30.0 CRP IL1R1 TNF
2 rheumatoid arthritis, systemic juvenile 29.7 IL1R1 IL6 MIF
3 cryopyrin-associated periodic syndrome 29.6 CRP IL1R1 IL1RN IL6
4 visceral leishmaniasis 29.5 CRP IL18 IL1B TNF
5 systemic onset juvenile idiopathic arthritis 29.4 IL18 IL1B MEFV TNF
6 pericarditis 29.0 CRP IL1B IL6 MEFV TNF
7 arthritis 27.4 CSF1 IL18 IL1B IL1RN IL6 MIF
8 wissler's syndrome 11.2
9 cold agglutinin disease 10.5 CRP IL6
10 diabetic foot ulcers 10.5 CRP IL6
11 neutrophilia, hereditary 10.5 CRP IL6
12 cardiogenic shock 10.5 CRP IL6
13 spinal disease 10.5 CRP IL6
14 scorpion envenomation 10.5 IL6 TNF
15 castleman disease 10.5 CRP IL6
16 angioimmunoblastic lymphadenopathy with dysproteinemia 10.4 IL6 TNF
17 angina pectoris 10.4 CRP IL6
18 critical limb ischemia 10.4 IL6 TNF
19 streptococcal toxic-shock syndrome 10.4 IL6 TNF
20 null-cell leukemia 10.4 IL6 TNF
21 melancholia 10.4 CRP TNF
22 viral pneumonia 10.4 CRP IL6
23 retinitis pigmentosa 55 10.4 IL6 TNF
24 glossitis 10.4 IL6 TNF
25 cecal disease 10.4 CRP IL6
26 listeria meningitis 10.4 IL18 TNF
27 relapsing polychondritis 10.4 CRP IL6
28 subacute thyroiditis 10.4 CRP IL6
29 anterior uveitis 10.4 IL6 TNF
30 paratyphoid fever 10.4 IL1R1 TNF
31 intussusception 10.4 CRP IL6
32 posterior urethral valves 10.4 IL6 TNF
33 autoinflammation, panniculitis, and dermatosis syndrome 10.4 MEFV TNF
34 hyper-igd syndrome 10.4 CRP IL1RN
35 amyloidosis aa 10.4 CRP MEFV
36 microscopic colitis 10.4 IL6 TNF
37 meconium aspiration syndrome 10.4 IL6 TNF
38 cartilage disease 10.3 CRP IL1RN
39 recurrent corneal erosion 10.3 IL1B IL6
40 bagassosis 10.3 IL1B IL6
41 acute cystitis 10.3 CRP IL18 IL6
42 hypersensitivity vasculitis 10.3 CRP MEFV
43 periodontitis, chronic 10.3 IL1B IL6
44 scleral disease 10.3 IL1RN TNF
45 erysipelas 10.3 MEFV TNF
46 polyposis, gastric 10.3 IL1B TNF
47 pericoronitis 10.3 CRP IL1B
48 suppurative otitis media 10.3 CRP IL1B
49 funisitis 10.3 IL1B IL6
50 periodic fever, familial, autosomal dominant 10.3 MEFV TNF

Graphical network of the top 20 diseases related to Adult-Onset Still's Disease:



Diseases related to Adult-Onset Still's Disease

Symptoms & Phenotypes for Adult-Onset Still's Disease

Human phenotypes related to Adult-Onset Still's Disease:

55 31 (show all 30)
# Description HPO Frequency Orphanet Frequency HPO Source Accession
1 skin rash 55 31 hallmark (90%) Very frequent (99-80%) HP:0000988
2 pruritus 55 31 hallmark (90%) Very frequent (99-80%) HP:0000989
3 meningitis 55 31 occasional (7.5%) Occasional (29-5%) HP:0001287
4 arthritis 55 31 hallmark (90%) Very frequent (99-80%) HP:0001369
5 joint swelling 55 31 hallmark (90%) Very frequent (99-80%) HP:0001386
6 pericarditis 55 31 frequent (33%) Frequent (79-30%) HP:0001701
7 splenomegaly 55 31 hallmark (90%) Very frequent (99-80%) HP:0001744
8 fever 55 31 hallmark (90%) Very frequent (99-80%) HP:0001945
9 leukocytosis 55 31 hallmark (90%) Very frequent (99-80%) HP:0001974
10 abdominal pain 55 31 frequent (33%) Frequent (79-30%) HP:0002027
11 pleuritis 55 31 frequent (33%) Frequent (79-30%) HP:0002102
12 hepatomegaly 55 31 hallmark (90%) Very frequent (99-80%) HP:0002240
13 arthralgia 55 31 hallmark (90%) Very frequent (99-80%) HP:0002829
14 elevated hepatic transaminases 55 31 occasional (7.5%) Occasional (29-5%) HP:0002910
15 abnormality of lipid metabolism 55 31 occasional (7.5%) Occasional (29-5%) HP:0003119
16 myalgia 55 31 frequent (33%) Frequent (79-30%) HP:0003326
17 elevated erythrocyte sedimentation rate 55 31 hallmark (90%) Very frequent (99-80%) HP:0003565
18 bone marrow hypocellularity 55 31 occasional (7.5%) Occasional (29-5%) HP:0005528
19 generalized lymphadenopathy 55 31 frequent (33%) Frequent (79-30%) HP:0008940
20 erythema 55 31 hallmark (90%) Very frequent (99-80%) HP:0010783
21 elevated c-reactive protein level 55 31 hallmark (90%) Very frequent (99-80%) HP:0011227
22 hepatitis 55 31 occasional (7.5%) Occasional (29-5%) HP:0012115
23 fatigue 55 31 hallmark (90%) Very frequent (99-80%) HP:0012378
24 myocarditis 55 31 occasional (7.5%) Occasional (29-5%) HP:0012819
25 cartilage destruction 55 31 occasional (7.5%) Occasional (29-5%) HP:0100773
26 recurrent pharyngitis 55 31 occasional (7.5%) Occasional (29-5%) HP:0100776
27 restrictive lung disease 55 Very frequent (99-80%)
28 neutrophillia 55 Very frequent (99-80%)
29 restrictive ventilatory defect 31 hallmark (90%) HP:0002091
30 neutrophilia 31 hallmark (90%) HP:0011897

UMLS symptoms related to Adult-Onset Still's Disease:


exanthema

MGI Mouse Phenotypes related to Adult-Onset Still's Disease:

43
# Description MGI Source Accession Score Top Affiliating Genes
1 hematopoietic system MP:0005397 10.1 MIF TNF MEFV CSF1 IL1R1 FCGR2A
2 cardiovascular system MP:0005385 10.08 TNF IL6 CSF1 IL1R1 IL1RN IL18
3 homeostasis/metabolism MP:0005376 10.07 MIF TNF IL6 MEFV CSF1 IL1R1
4 cellular MP:0005384 10.06 MEFV MIF TNF IL6 CSF1 IL1R1
5 immune system MP:0005387 10.06 MIF TNF MEFV CSF1 IL1R1 FCGR2A
6 growth/size/body region MP:0005378 10.03 MEFV TNF IL6 IL1B CSF1 IL1R1
7 integument MP:0010771 9.86 TNF MEFV CSF1 IL1R1 IL1RN IL18
8 mortality/aging MP:0010768 9.81 TNF IL6 MEFV CSF1 IL1R1 FCGR2A
9 neoplasm MP:0002006 9.35 MIF TNF IL6 IL1R1 IL1B
10 skeleton MP:0005390 9.23 TNF MEFV CSF1 IL1R1 FCGR2A IL1RN

Drugs & Therapeutics for Adult-Onset Still's Disease

Drugs for Adult-Onset Still's Disease (from DrugBank, HMDB, Dgidb, PharmGKB, IUPHAR, NovoSeek, BitterDB):

(show all 26)
# Name Status Phase Clinical Trials Cas Number PubChem Id
1 Antirheumatic Agents Phase 3,Phase 2
2 Interleukin 1 Receptor Antagonist Protein Phase 3,Phase 2
3
Azathioprine Approved Phase 2 446-86-6 2265
4
Leflunomide Approved, Investigational Phase 2 75706-12-6 3899
5
Methotrexate Approved Phase 2 1959-05-2, 59-05-2 126941
6
Methylprednisolone Approved, Vet_approved Phase 2 83-43-2 6741
7
Prednisolone Approved, Vet_approved Phase 2 50-24-8 5755
8
Folic Acid Approved, Nutraceutical, Vet_approved Phase 2 59-30-3 6037
9
leucovorin Approved, Nutraceutical Phase 2 58-05-9 143 6006
10 Antibodies Phase 2
11 Antibodies, Monoclonal Phase 2
12 Immunoglobulins Phase 2
13 Antimetabolites Phase 2
14 Antimetabolites, Antineoplastic Phase 2
15 Dermatologic Agents Phase 2
16 Folic Acid Antagonists Phase 2
17 Immunosuppressive Agents Phase 2
18 Methylprednisolone acetate Phase 2
19 Methylprednisolone Hemisuccinate Phase 2
20 Nucleic Acid Synthesis Inhibitors Phase 2
21 Prednisolone acetate Phase 2
22 Prednisolone hemisuccinate Phase 2
23 Prednisolone phosphate Phase 2
24 Vitamin B Complex Phase 2
25 Folate Nutraceutical Phase 2
26 Vitamin B9 Nutraceutical Phase 2

Interventional clinical trials:


# Name Status NCT ID Phase Drugs
1 A Study to Evaluate Efficacy and Safety of Anakinra in the Treatment of Still's Disease (SJIA and AOSD) Recruiting NCT03265132 Phase 3 Placebo
2 Efficacy and Safety of Tocilizumab in Adult's Still Disease Unknown status NCT01002781 Phase 2 Tocilizumab
3 Treatment of Refractory Adult-onset Still's Disease With Anakinra: a Randomized Study Completed NCT01033656 Phase 2 anakinra;comparators
4 Therapeutic Use of Tadekinig Alfa in Adult-onset Still's Disease Completed NCT02398435 Phase 2
5 Interleukin-1 Trap to Treat Autoinflammatory Diseases Completed NCT00094900 Phase 2 IL-1 Trap
6 Canakinumab for Treatment of Adult Onset Still's Disease Recruiting NCT02204293 Phase 2 Canakinumab;Placebo Injection;Canakinumab
7 Tocilizumab in Patients With Schnitzler's Syndrome Recruiting NCT03046381 Phase 2 Tocilizumab
8 Admission of Adult-onset Still Disease Patients in the ICU Recruiting NCT03276650
9 Glycosylated Ferritin in Macrophagic Activation Syndromes Recruiting NCT02143986

Search NIH Clinical Center for Adult-Onset Still's Disease

Cochrane evidence based reviews: still's disease, adult-onset

Genetic Tests for Adult-Onset Still's Disease

Anatomical Context for Adult-Onset Still's Disease

MalaCards organs/tissues related to Adult-Onset Still's Disease:

38
Liver, Bone, Skin, Lung, Lymph Node, T Cells, Bone Marrow

Publications for Adult-Onset Still's Disease

Articles related to Adult-Onset Still's Disease:

(show top 50) (show all 645)
# Title Authors Year
1
Acute appendicitis complicated with necrotizing fasciitis in a patient with adult-onset Still's disease: A case report. ( 29384877 )
2018
2
Two Severe Cases of Adult-onset Still's Disease with Persistent Pruritic Eruptions. ( 29362813 )
2018
3
Early use of anakinra in adult-onset Still's disease myocarditis. ( 29291663 )
2018
4
Evidence for genetic overlap between adult onset Still's disease and hereditary periodic fever syndromes. ( 29159471 )
2018
5
Impaired autophagic flux and its related inflammation in patients with adult-onset Still's disease. ( 29416600 )
2018
6
Biological therapy of traditional therapy-resistant adult-onset Still's disease: an evidence-based review. ( 29416343 )
2018
7
Generalized Purpura as an Atypical Skin Manifestation of Adult-onset Still's Disease in a Patient with BehAset's Disease. ( 29313056 )
2018
8
Beneficial use of serum ferritin and heme oxygenase-1 as biomarkers in adult-onset Still's disease: A multicenter retrospective study. ( 29278009 )
2018
9
Efficacy and safety of tocilizumab with inhibition of interleukin-6 in adult-onset Still's disease: A meta-analysis. ( 29251027 )
2018
10
Biologic drugs in adult onset Still's disease: a systematic review and meta-analysis of observational studies. ( 28870100 )
2017
11
New Markers for Adult-Onset Still's Disease. ( 28529117 )
2017
12
Rumpel-Leede phenomenon in a patient with adult-onset Still's disease. ( 28130282 )
2017
13
Autophagy inhibition in adult-onset Still's disease: still more space for hydroxychloroquine? ( 29148405 )
2017
14
Purulent constrictive pericarditis caused by Salmonella enteritidis in a patient with adult-onset Still's disease: A case report. ( 29390286 )
2017
15
The neutrophil-to-lymphocyte ratio could be a good diagnostic marker and predictor of relapse in patients with adult-onset Still's disease: A STROBE-compliant retrospective observational analysis. ( 28723775 )
2017
16
Utility and drawbacks of [18]F-fluorodeoxyglucose positron emission tomography in the evaluation of adult-onset Still's disease. ( 29096430 )
2017
17
A case of adult-onset Still's disease accompanied by pseudo-gray platelet syndrome. ( 29043244 )
2017
18
Atypical form of adult-onset Still's disease with distal interphalangeal joints involvement. ( 28758587 )
2017
19
Adult-Onset Still's Disease: Still a Serious Health Problem (a Case Report and Literature Review). ( 28154368 )
2017
20
Adult-onset Still's disease with atypical cutaneous manifestations. ( 28296747 )
2017
21
Imaging characteristics of adult onset Still's disease demonstrated with 18F-FDG PET/CT. ( 28765926 )
2017
22
Adult onset Still's Disease. ( 29241877 )
2017
23
Phosphorylated signal transducer and activator of transcription 3 in the epidermis in adult-onset Still's disease. ( 28470759 )
2017
24
Delay in the Diagnosis of Adult-Onset Still's Disease. ( 28690954 )
2017
25
Upregulation of circulating microRNA-134 in adult-onset Still's disease and its use as potential biomarker. ( 28646209 )
2017
26
Elevated circulating levels of the interferon-I^-induced chemokines are associated with disease activity and cutaneous manifestations in adult-onset Still's disease. ( 28436448 )
2017
27
Hemophagocytic lymphohistiocytosis with high serum levels of IL-18 and predominant lymphocyte activation in a neonate born to a mother with adult-onset Still's disease. ( 28450255 )
2017
28
Red blood cell distribution width is useful in discriminating adult onset Still's disease and sepsis within 24 hours after hospitalization. ( 28838228 )
2017
29
Validation of the Fautrel classification criteria for adult-onset Still's disease. ( 28760536 )
2017
30
Highly Expression of CD11b and CD32 on Peripheral Blood Mononuclear Cells from Patients with Adult-Onset Still's Disease. ( 28106835 )
2017
31
Adult-onset Still's disease-like condition due to alcoholic hepatitis and vitamin B deficiency. ( 28691376 )
2017
32
Effects of HLA-DRB1 alleles on susceptibility and clinical manifestations in Japanese patients with adult onset Still's disease. ( 28899403 )
2017
33
Diagnostic Challenge: A Report of Two Adult-Onset Still's Disease Cases. ( 29147588 )
2017
34
Visceral leishmaniasis triggering an adult-onset Still's disease: a unique case. ( 29225867 )
2017
35
Treatment of adult-onset still's disease: up to date. ( 28540751 )
2017
36
Refractory Adult Onset Still's Disease. ( 29282446 )
2017
37
Adult-onset Still's disease in a patient with psoriasis vulgaris showing inverse correlation of disease activity. ( 29083047 )
2017
38
How I treat patients with adult onset Still's disease in clinical practice. ( 28778712 )
2017
39
Adult-onset Still's disease presenting with shawl sign-like eruption. ( 28925003 )
2017
40
Inadvertent Skipping of Steroids in Septic Shock Leads to a Diagnosis of Adult Onset Still's Disease. ( 28191382 )
2017
41
A Pilot Study on Tocilizumab for Treating Refractory Adult-Onset Still's Disease. ( 29044212 )
2017
42
Extremely High Serum Ferritin: An Instrumental Marker of Masquerading Adult-Onset Still's Disease with Hemophagocytic Syndrome. ( 29208852 )
2017
43
Response to Interleukin-1 Inhibitors in 140 Italian Patients with Adult-Onset Still's Disease: A Multicentre Retrospective Observational Study. ( 28659802 )
2017
44
Pneumonitis in Adult Onset Still's Disease: Uncommon or Under Diagnosed? ( 28926333 )
2017
45
Unusual manifestations and unusual mimics of adult onset Still's disease. ( 28397955 )
2017
46
Adult-Onset Still's Disease: Is This Truly a Diagnosis of Exclusion? ( 29164007 )
2017
47
Adult onset Still's disease-The evidence that anti-interleukin-1 treatment is effective and well-tolerated (a comprehensive literature review). ( 28757235 )
2017
48
Serum Levels of Interleukin 33 and Soluble ST2 Are Associated with the Extent of Disease Activity and Cutaneous Manifestations in Patients with Active Adult-onset Still's Disease. ( 28365573 )
2017
49
Adult-onset Still's disease with myocarditis and hemophagocytic lymphohistiocytosis: Rare manifestation with fatal outcome. ( 26960645 )
2016
50
Response rate of initial conventional treatments, disease course, and related factors of patients with adult-onset Still's disease: Data from a large multicenter cohort. ( 26970681 )
2016

Variations for Adult-Onset Still's Disease

Expression for Adult-Onset Still's Disease

Search GEO for disease gene expression data for Adult-Onset Still's Disease.

Pathways for Adult-Onset Still's Disease

Pathways related to Adult-Onset Still's Disease according to GeneCards Suite gene sharing:

(show top 50) (show all 64)
# Super pathways Score Top Affiliating Genes
1
Show member pathways
13.79 CRP CSF1 FCGR2A IL18 IL1B IL1R1
2
Show member pathways
13.58 CSF1 IL18 IL1B IL1R1 IL6 MIF
3
Show member pathways
13.34 CSF1 IL18 IL1B IL1R1 IL6 TNF
4
Show member pathways
13.31 CSF1 IL18 IL1B IL1R1 IL1RN IL6
5
Show member pathways
13.24 CSF1 IL18 IL1B IL1R1 IL6 TNF
6
Show member pathways
12.85 IL18 IL1B IL1R1 IL1RN IL6 MEFV
7
Show member pathways
12.73 IL18 IL1B IL6 TNF
8 12.69 CSF1 IL1B IL1R1 TNF
9
Show member pathways
12.66 IL18 IL1B IL6 TNF
10
Show member pathways
12.64 IL1B IL1R1 IL6 TNF
11
Show member pathways
12.58 IL18 IL1B IL1R1 IL6 TNF
12
Show member pathways
12.55 IL18 IL1B IL6 TNF
13
Show member pathways
12.31 CRP CSF1 IL1B IL6 TNF
14
Show member pathways
12.22 IL1B IL1R1 IL6 MIF TNF
15 12.2 FCGR2A IL18 IL1B IL6 TNF
16
Show member pathways
12.19 IL1B IL1R1 IL6 TNF
17
Show member pathways
12.18 FCGR2A IL1B TNF
18 12.18 IL1B IL1RN IL6 TNF
19
Show member pathways
12.16 IL18 IL1B IL6 TNF
20 12.04 IL1B IL1R1 TNF
21 12.02 IL6 MIF TNF
22 12 CSF1 FCGR2A IL6 TNF
23 11.99 IL18 IL1B IL6 TNF
24 11.96 CSF1 IL1B IL6 TNF
25
Show member pathways
11.95 IL18 IL1B IL1R1
26
Show member pathways
11.94 IL18 IL1B IL6 TNF
27 11.94 CSF1 FCGR2A IL1B IL1R1 TNF
28 11.89 IL1B IL1R1 IL6 TNF
29 11.88 IL1B IL6 TNF
30 11.86 IL1B IL1R1 TNF
31
Show member pathways
11.84 IL1B IL1R1 IL6
32 11.81 IL18 IL1B IL6
33 11.8 IL18 IL1B IL1R1 TNF
34 11.75 IL1B IL6 TNF
35 11.75 CSF1 IL1B IL6 TNF
36 11.69 FCGR2A IL6 TNF
37
Show member pathways
11.67 IL1B IL6 MIF TNF
38 11.66 IL1B IL6 TNF
39 11.64 CSF1 IL1B IL1R1 IL6 TNF
40 11.58 IL18 IL1B IL6 TNF
41 11.54 CSF1 IL1B IL6
42 11.51 IL1B IL6 TNF
43 11.51 CSF1 IL18 IL1B IL6 TNF
44 11.51 FCGR2A IL1B IL1R1 IL6 MIF TNF
45 11.5 IL18 IL1B IL6 TNF
46
Show member pathways
11.49 IL1B IL1R1 TNF
47 11.48 CSF1 IL18 IL1B TNF
48 11.46 IL18 IL1B MEFV
49 11.38 IL1B IL6 TNF
50 11.32 IL1B IL6 TNF

GO Terms for Adult-Onset Still's Disease

Cellular components related to Adult-Onset Still's Disease according to GeneCards Suite gene sharing:

# Name GO ID Score Top Affiliating Genes
1 extracellular exosome GO:0070062 9.8 CRP CSF1 FCGR2A IL18 IL1B IL1RN
2 extracellular space GO:0005615 9.56 CRP CSF1 IL18 IL1B IL1RN IL6
3 vesicle GO:0031982 9.33 IL1B IL1RN MIF
4 extracellular region GO:0005576 9.28 CRP CSF1 IL18 IL1B IL1R1 IL1RN

Biological processes related to Adult-Onset Still's Disease according to GeneCards Suite gene sharing:

(show all 38)
# Name GO ID Score Top Affiliating Genes
1 positive regulation of protein phosphorylation GO:0001934 9.84 IL1B MIF TNF
2 cytokine-mediated signaling pathway GO:0019221 9.83 IL1B IL1R1 IL6
3 positive regulation of NF-kappaB transcription factor activity GO:0051092 9.83 IL1B IL6 TNF
4 positive regulation of DNA binding transcription factor activity GO:0051091 9.8 IL1B IL6 TNF
5 immune response GO:0006955 9.8 IL18 IL1B IL1R1 IL1RN IL6 TNF
6 defense response to Gram-positive bacterium GO:0050830 9.79 CRP IL6 TNF
7 positive regulation of peptidyl-serine phosphorylation GO:0033138 9.77 IL6 MIF TNF
8 cellular response to organic cyclic compound GO:0071407 9.77 IL18 IL1B TNF
9 response to glucocorticoid GO:0051384 9.73 IL1RN IL6 TNF
10 positive regulation of smooth muscle cell proliferation GO:0048661 9.72 IL18 IL6 TNF
11 positive regulation of interleukin-8 production GO:0032757 9.68 IL1B TNF
12 osteoclast differentiation GO:0030316 9.67 CSF1 TNF
13 negative regulation of myoblast differentiation GO:0045662 9.67 IL18 TNF
14 positive regulation of osteoclast differentiation GO:0045672 9.66 CSF1 TNF
15 positive regulation of chemokine production GO:0032722 9.65 IL6 TNF
16 negative regulation of lipid catabolic process GO:0050995 9.65 IL1B TNF
17 positive regulation of interleukin-6 production GO:0032755 9.65 IL1B IL6 TNF
18 positive regulation of macrophage derived foam cell differentiation GO:0010744 9.64 CSF1 IL18
19 positive regulation of membrane protein ectodomain proteolysis GO:0051044 9.64 IL1B TNF
20 regulation of I-kappaB kinase/NF-kappaB signaling GO:0043122 9.63 IL1B TNF
21 positive regulation of interferon-gamma production GO:0032729 9.63 IL18 IL1B TNF
22 positive regulation of gene expression GO:0010628 9.63 CRP CSF1 IL18 IL1B IL6 TNF
23 positive regulation of heterotypic cell-cell adhesion GO:0034116 9.62 IL1B TNF
24 positive regulation of granulocyte macrophage colony-stimulating factor production GO:0032725 9.62 IL18 IL1B
25 positive regulation of chemokine biosynthetic process GO:0045080 9.61 IL1B TNF
26 regulation of establishment of endothelial barrier GO:1903140 9.58 IL1B TNF
27 interleukin-6 production GO:0032635 9.58 IL18 IL1B
28 lipopolysaccharide-mediated signaling pathway GO:0031663 9.58 IL18 IL1B TNF
29 positive regulation of chemokine (C-X-C motif) ligand 2 production GO:2000343 9.57 MIF TNF
30 fever generation GO:0001660 9.54 IL1B IL1RN
31 positive regulation of NF-kappaB import into nucleus GO:0042346 9.54 IL18 IL1B TNF
32 positive regulation of fever generation GO:0031622 9.52 IL1B TNF
33 sequestering of triglyceride GO:0030730 9.51 IL1B TNF
34 regulation of receptor activity GO:0010469 9.5 CSF1 IL18 IL1B IL1RN IL6 MIF
35 negative regulation of interleukin-1-mediated signaling pathway GO:2000660 9.49 IL1RN IL6
36 positive regulation of calcidiol 1-monooxygenase activity GO:0060559 9.43 IL1B TNF
37 negative regulation of lipid storage GO:0010888 9.43 CRP IL6 TNF
38 inflammatory response GO:0006954 9.28 CRP CSF1 IL18 IL1B IL1RN IL6

Molecular functions related to Adult-Onset Still's Disease according to GeneCards Suite gene sharing:

# Name GO ID Score Top Affiliating Genes
1 identical protein binding GO:0042802 9.72 CRP CSF1 MEFV MIF TNF
2 cytokine activity GO:0005125 9.17 CSF1 IL18 IL1B IL1RN IL6 MIF
3 interleukin-1 receptor binding GO:0005149 9.16 IL1B IL1RN
4 protease binding GO:0002020 9.13 IL1R1 MIF TNF
5 protein binding GO:0005515 10 CRP CSF1 FCGR2A IL18 IL1B IL1R1

Sources for Adult-Onset Still's Disease

3 CDC
7 CNVD
9 Cosmic
10 dbSNP
11 DGIdb
16 ExPASy
18 FMA
27 GO
28 GTR
29 HGMD
30 HMDB
31 HPO
32 ICD10
33 ICD10 via Orphanet
34 ICD9CM
35 IUPHAR
36 KEGG
37 LifeMap
39 MedGen
41 MeSH
42 MESH via Orphanet
43 MGI
45 NCI
46 NCIt
47 NDF-RT
50 NINDS
51 Novoseek
53 OMIM
54 OMIM via Orphanet
58 PubMed
60 QIAGEN
65 SNOMED-CT via HPO
66 SNOMED-CT via Orphanet
67 TGDB
68 Tocris
69 UMLS
70 UMLS via Orphanet
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