AOSD
MCID: ADL030
MIFTS: 59

Adult-Onset Still's Disease (AOSD) malady

Categories: Rare diseases, Nephrological diseases, Bone diseases

Aliases & Classifications for Adult-Onset Still's Disease

Aliases & Descriptions for Adult-Onset Still's Disease:

Name: Adult-Onset Still's Disease 12 50 14
Adult-Onset Still Disease 12 56 69
Still's Disease, Adult-Onset 42
Adult Onset Still's Disease 12
Still's Disease Adult Onset 50
Stills Disease Adult-Onset 52
Wissler-Fanconi Syndrome 56
Adult Still's Disease 50
Wissler's Syndrome 69
Aosd 56

Characteristics:

Orphanet epidemiological data:

56
adult-onset still disease
Inheritance: Not applicable; Prevalence: 1-9/1000000 (France),1-9/1000000 (Japan),1-9/1000000 (Norway),1-9/100000 (Norway),1-9/100000 (Europe),1-9/1000000 (Turkey),1-9/100000 (Turkey); Age of onset: Adult; Age of death: normal life expectancy;

Classifications:



External Ids:

Disease Ontology 12 DOID:14256
ICD10 33 M06.1
MeSH 42 D016706
Orphanet 56 ORPHA829
ICD10 via Orphanet 34 M06.1
UMLS via Orphanet 70 C0085253 C0043195
MESH via Orphanet 43 D014924 D016706
UMLS 69 C0085253

Summaries for Adult-Onset Still's Disease

NIH Rare Diseases : 50 adult-onset still's disease is an inflammatory condition characterized by high fevers, rash, sore throat, and joint pain. as it progresses, adult-onset still's disease may lead to chronic arthritis and other complications. still's disease was named after an english doctor named george still, who described the condition in children in 1896. still's disease which occurs in children (those under the age of 16) is now known as systemic onset juvenile rheumatoid arthritis (jra). in 1971, the term "adult still's disease" was used to describe adults who had a condition similar to systemic onset jra. the cause of adult-onset still's disease is unknown. no risk factors for the disease have been identified. there's no cure for adult-onset still's disease; however, treatment may offer symptom relief and help prevent complications.  last updated: 5/28/2014

MalaCards based summary : Adult-Onset Still's Disease, also known as adult-onset still disease, is related to wissler's syndrome and coloboma of iris, and has symptoms including pruritus, arthralgia and fatigue. An important gene associated with Adult-Onset Still's Disease is IL18 (Interleukin 18), and among its related pathways/superpathways are Innate Immune System and PEDF Induced Signaling. The drugs Methotrexate and Azathioprine have been mentioned in the context of this disorder. Affiliated tissues include liver, bone and skin, and related phenotypes are Decreased shRNA abundance (Z-score < -2) and homeostasis/metabolism

Disease Ontology : 12 An arthritis that is a rare from of inflammatory arthritis characterized by fevers, rash, and joint pain.

Related Diseases for Adult-Onset Still's Disease

Diseases related to Adult-Onset Still's Disease via text searches within MalaCards or GeneCards Suite gene sharing:

(show top 50) (show all 230)
id Related Disease Score Top Affiliating Genes
1 wissler's syndrome 11.1
2 coloboma of iris 10.3 CRP IL6
3 vps11-related autosomal recessive hypomyelinating leukodystrophy 10.3 IL6 TNF
4 neutrophilia, hereditary 10.2 CRP IL6
5 dyslexia 5 10.2 IL6 TNF
6 aortic atherosclerosis 10.2 IL6 TNF
7 degenerative disc disease 10.2 IL6 TNF
8 cardiac tuberculosis 10.2 CRP IL6
9 thymic neuroendocrine carcinoma 10.2 IL6 TNF
10 psoriatic arthritis 10.2 IL18 TNF
11 drug dependence 10.2 IL6 TNF
12 myeloid neoplasms associated with pdgfrb rearrangement 10.2 MEFV TNF
13 fanconi syndrome 10.2
14 cataract, total congenital 10.2 CRP IL6
15 allergic bronchopulmonary aspergillosis 10.2 CRP IL18 IL6
16 candidiasis, familial, 4, autosomal recessive 10.2 MEFV TNF
17 fallopian tube adenomatoid tumor 10.2 CRP IL1RN
18 transient tic disorder 10.2 IL6 TNF
19 immunodeficiency 9 10.2 CRP IL1RN
20 papilledema 10.2 IL6 TNF
21 angiomatosis, diffuse corticomeningeal, of divry and van bogaert 10.2 IL6 TNF
22 lacrimal system cancer 10.2 CRP IL18 IL6
23 unilateral multicystic dysplastic kidney 10.2 CRP IL6 TNF
24 intussusception 10.2 IL1B TNF
25 swine influenza 10.2 CRP IL6 TNF
26 red cell phospholipid defect with hemolysis 10.2 IL18 IL6 TNF
27 joint disorders 10.2 CRP IL6 TNF
28 cicatricial lagophthalmos 10.2 CRP IL6 TNF
29 oculomotor nerve paralysis 10.2 IL1B IL6
30 autoimmune disease of central nervous system 10.1 CRP IL6 TNF
31 common peroneal nerve lesion 10.1 IL1B IL6
32 plummer's disease 10.1 CRP IL6 TNF
33 nemaline myopathy 1, autosomal dominant or recessive 10.1 IL1RN TNF
34 follicular adenoma 10.1 CRP IL6 TNF
35 carotenemia 10.1 CRP IL6 TNF
36 retinitis pigmentosa 51 10.1 CRP IL6 TNF
37 bile duct signet ring cell carcinoma 10.1 CRP IL1R1 TNF
38 chondroma 10.1 CRP IL6 TNF
39 amelogenesis imperfecta 10.1 CRP IL6 TNF
40 functional gastric disease 10.1 CRP IL1R1 TNF
41 esotropia 10.1 CRP IL6 MEFV
42 asbestosis 10.1 CRP IL6 TNF
43 limb ischemia 10.1 CRP IL6 TNF
44 tetanus 10.1 MEFV TNF
45 neonatal jaundice 10.1 IL18 IL6 TNF
46 pemphigus vulgaris, familial 10.1 CRP IL6 TNF
47 familial nephrotic syndrome 10.1 CRP IL6 TNF
48 diabetic encephalopathy 10.1 CRP IL6 TNF
49 primary ciliary dyskinesia 10.1 IL1R1 IL6 TNF
50 neovascular glaucoma 10.1 CRP IL6 TNF

Graphical network of the top 20 diseases related to Adult-Onset Still's Disease:



Diseases related to Adult-Onset Still's Disease

Symptoms & Phenotypes for Adult-Onset Still's Disease

Human phenotypes related to Adult-Onset Still's Disease:

56 32 (show all 29)
id Description HPO Frequency Orphanet Frequency HPO Source Accession
1 pruritus 56 32 Very frequent (99-80%) HP:0000989
2 arthralgia 56 32 Very frequent (99-80%) HP:0002829
3 fatigue 56 32 Very frequent (99-80%) HP:0012378
4 myalgia 56 32 Frequent (79-30%) HP:0003326
5 fever 56 32 Very frequent (99-80%) HP:0001945
6 abdominal pain 56 32 Frequent (79-30%) HP:0002027
7 joint swelling 56 32 Very frequent (99-80%) HP:0001386
8 recurrent pharyngitis 56 32 Occasional (29-5%) HP:0100776
9 arthritis 56 32 Very frequent (99-80%) HP:0001369
10 splenomegaly 56 32 Very frequent (99-80%) HP:0001744
11 hepatomegaly 56 32 Very frequent (99-80%) HP:0002240
12 hepatitis 56 32 Occasional (29-5%) HP:0012115
13 bone marrow hypocellularity 56 32 Occasional (29-5%) HP:0005528
14 elevated hepatic transaminases 56 32 Occasional (29-5%) HP:0002910
15 abnormality of lipid metabolism 56 32 Occasional (29-5%) HP:0003119
16 leukocytosis 56 32 Very frequent (99-80%) HP:0001974
17 erythema 56 32 Very frequent (99-80%) HP:0010783
18 pericarditis 56 32 Frequent (79-30%) HP:0001701
19 myocarditis 56 32 Occasional (29-5%) HP:0012819
20 skin rash 56 32 Very frequent (99-80%) HP:0000988
21 meningitis 56 32 Occasional (29-5%) HP:0001287
22 elevated c-reactive protein level 56 32 Very frequent (99-80%) HP:0011227
23 cartilage destruction 56 32 Occasional (29-5%) HP:0100773
24 pleuritis 56 32 Frequent (79-30%) HP:0002102
25 elevated erythrocyte sedimentation rate 56 32 Very frequent (99-80%) HP:0003565
26 generalized lymphadenopathy 56 32 Frequent (79-30%) HP:0008940
27 neutrophillia 56 32 Very frequent (99-80%) HP:0011897
28 restrictive lung disease 56 Very frequent (99-80%)
29 restrictive ventilatory defect 32 HP:0002091

UMLS symptoms related to Adult-Onset Still's Disease:


exanthema

GenomeRNAi Phenotypes related to Adult-Onset Still's Disease according to GeneCards Suite gene sharing:

26
id Description GenomeRNAi Source Accession Score Top Affiliating Genes
1 Decreased shRNA abundance (Z-score < -2) GR00366-A-116 9.58 MIF CSF1 IL1B IL1R1
2 Decreased shRNA abundance (Z-score < -2) GR00366-A-139 9.58 IL1R1 IL1B
3 Decreased shRNA abundance (Z-score < -2) GR00366-A-14 9.58 IL1B
4 Decreased shRNA abundance (Z-score < -2) GR00366-A-142 9.58 CSF1
5 Decreased shRNA abundance (Z-score < -2) GR00366-A-17 9.58 MIF
6 Decreased shRNA abundance (Z-score < -2) GR00366-A-180 9.58 CSF1
7 Decreased shRNA abundance (Z-score < -2) GR00366-A-181 9.58 IL1B
8 Decreased shRNA abundance (Z-score < -2) GR00366-A-33 9.58 IL1R1
9 Decreased shRNA abundance (Z-score < -2) GR00366-A-72 9.58 MIF
10 Decreased shRNA abundance (Z-score < -2) GR00366-A-75 9.58 MIF
11 Decreased shRNA abundance (Z-score < -2) GR00366-A-84 9.58 CSF1
12 Decreased shRNA abundance (Z-score < -2) GR00366-A-87 9.58 MIF
13 Decreased shRNA abundance (Z-score < -2) GR00366-A-91 9.58 CSF1
14 Decreased shRNA abundance (Z-score < -2) GR00366-A-98 9.58 MIF

MGI Mouse Phenotypes related to Adult-Onset Still's Disease:

44
id Description MGI Source Accession Score Top Affiliating Genes
1 homeostasis/metabolism MP:0005376 10.07 MIF TNF IL18 IL6 IL1B MEFV
2 cardiovascular system MP:0005385 10.06 TNF IL18 IL6 IL1B IL1R1 CRP
3 hematopoietic system MP:0005397 10.06 MIF TNF IL18 IL6 IL1B MEFV
4 cellular MP:0005384 10.03 TNF MIF IL1RN IL18 IL6 MEFV
5 immune system MP:0005387 10.02 MIF TNF IL18 IL6 IL1B MEFV
6 integument MP:0010771 9.86 TNF IL18 IL6 IL1B MEFV IL1R1
7 liver/biliary system MP:0005370 9.55 TNF CSF1 IL6 MEFV IL1R1
8 neoplasm MP:0002006 9.35 TNF MIF IL6 IL1B IL1R1
9 skeleton MP:0005390 9.17 TNF IL1RN IL6 IL1B MEFV IL1R1

Drugs & Therapeutics for Adult-Onset Still's Disease

Drugs for Adult-Onset Still's Disease (from DrugBank, HMDB, Dgidb, PharmGKB, IUPHAR, NovoSeek, BitterDB):

(show all 27)
id Name Status Phase Clinical Trials Cas Number PubChem Id
1
Methotrexate Approved Phase 2 1959-05-2, 59-05-2 126941
2
Azathioprine Approved Phase 2 446-86-6 2265
3
Prednisolone Approved, Vet_approved Phase 2 50-24-8 5755
4
Leflunomide Approved, Investigational Phase 2 75706-12-6 3899
5
Methylprednisolone Approved, Vet_approved Phase 2 83-43-2 6741
6
leucovorin Approved, Nutraceutical Phase 2 58-05-9 54575, 6560146 143
7
Folic Acid Approved, Nutraceutical, Vet_approved Phase 2 59-30-3 6037
8 Immunoglobulins Phase 2
9 Antibodies, Monoclonal Phase 2
10 Antibodies Phase 2
11 Prednisolone acetate Phase 2
12 Chelating Agents Phase 2
13 Folic Acid Antagonists Phase 2
14 Nucleic Acid Synthesis Inhibitors Phase 2
15 Dermatologic Agents Phase 2
16 Vitamin B Complex Phase 2
17 Prednisolone hemisuccinate Phase 2
18 Prednisolone phosphate Phase 2
19 Immunosuppressive Agents Phase 2
20 Interleukin 1 Receptor Antagonist Protein Phase 2
21 Antimetabolites Phase 2
22 Antimetabolites, Antineoplastic Phase 2
23 Methylprednisolone acetate Phase 2
24 Methylprednisolone Hemisuccinate Phase 2
25 Antirheumatic Agents Phase 2
26 Folate Nutraceutical Phase 2
27 Vitamin B9 Nutraceutical Phase 2

Interventional clinical trials:


id Name Status NCT ID Phase
1 Efficacy and Safety of Tocilizumab in Adult's Still Disease Unknown status NCT01002781 Phase 2
2 Treatment of Refractory Adult-onset Still's Disease With Anakinra: a Randomized Study Completed NCT01033656 Phase 2
3 Therapeutic Use of Tadekinig Alfa in Adult-onset Still's Disease Completed NCT02398435 Phase 2
4 Interleukin-1 Trap to Treat Autoinflammatory Diseases Completed NCT00094900 Phase 2
5 The Empowerment Model Towards Type 2 Diabetic Adults To Enhance Vegetable Intake in Achieving Glycemic Control Completed NCT01828242 Phase 2
6 Canakinumab for Treatment of Adult Onset Still's Disease Recruiting NCT02204293 Phase 2
7 Tocilizumab in Patients With Schnitzler's Syndrome Not yet recruiting NCT03046381 Phase 2
8 Glycosylated Ferritin in Macrophagic Activation Syndromes Recruiting NCT02143986

Search NIH Clinical Center for Adult-Onset Still's Disease

Cochrane evidence based reviews: still's disease, adult-onset

Genetic Tests for Adult-Onset Still's Disease

Anatomical Context for Adult-Onset Still's Disease

MalaCards organs/tissues related to Adult-Onset Still's Disease:

39
Liver, Bone, Skin, Lung, T Cells, Lymph Node, Bone Marrow

Publications for Adult-Onset Still's Disease

Articles related to Adult-Onset Still's Disease:

(show top 50) (show all 608)
id Title Authors Year
1
Rumpel-Leede phenomenon in a patient with adult-onset Still's disease. ( 28130282 )
2017
2
Unusual manifestations and unusual mimics of adult onset Still's disease. ( 28397955 )
2017
3
Hemophagocytic lymphohistiocytosis with high serum levels of IL-18 and predominant lymphocyte activation in a neonate born to a mother with adult-onset Still's disease. ( 28450255 )
2017
4
Adult-onset Still's disease with atypical cutaneous manifestations. ( 28296747 )
2017
5
Serum Levels of Interleukin 33 and Soluble ST2 Are Associated with the Extent of Disease Activity and Cutaneous Manifestations in Patients with Active Adult-onset Still's Disease. ( 28365573 )
2017
6
Adult-Onset Still's Disease: Still a Serious Health Problem (a Case Report and Literature Review). ( 28154368 )
2017
7
Phosphorylated signal transducer and activator of transcription 3 in the epidermis in adult-onset Still's disease. ( 28470759 )
2017
8
New Markers for Adult-Onset Still's Disease. ( 28529117 )
2017
9
Elevated circulating levels of the interferon-I^-induced chemokines are associated with disease activity and cutaneous manifestations in adult-onset Still's disease. ( 28436448 )
2017
10
Highly Expression of CD11b and CD32 on Peripheral Blood Mononuclear Cells from Patients with Adult-Onset Still's Disease. ( 28106835 )
2017
11
Inadvertent Skipping of Steroids in Septic Shock Leads to a Diagnosis of Adult Onset Still's Disease. ( 28191382 )
2017
12
Epidemiological study of adult-onset Still's disease using a Japanese administrative database. ( 27502500 )
2016
13
Adult onset Still's disease with dermatopathic lymphadenopathy. ( 27761568 )
2016
14
Adult-onset Still's disease: current challenges and future prospects. ( 27843366 )
2016
15
Histological findings in the spleen affected by adult-onset Still's disease: a report of three cases. ( 26841850 )
2016
16
Persistent Pruritic Lesions in Adult-onset Still's Disease. ( 27865305 )
2016
17
Efficacy of tocilizumab therapy in Korean patients with adult-onset Still's disease: a multicentre retrospective study of 22 cases. ( 27462914 )
2016
18
Successful treatment of refractory adult onset Still's disease with rituximab. ( 27981819 )
2016
19
Adult onset Still's disease accompanied by acute respiratory distress syndrome: A case report. ( 27588099 )
2016
20
Successful Tocilizumab Therapy for Macrophage Activation Syndrome Associated with Adult-Onset Still's Disease: A Case-Based Review. ( 27688774 )
2016
21
Herpes Zoster Meningitis Complicating Combined Tocilizumab and Cyclosporine Therapy for Adult-Onset Still's Disease. ( 27092286 )
2016
22
A case report of successful treatment of 90A^ knee flexion contracture in a patient with adult-onset Still's disease. ( 26860205 )
2016
23
Adult onset still's disease- A rare presentation. ( 27728682 )
2016
24
Adult-onset Still's disease: an Italian multicentre retrospective observational study of manifestations and treatments in 245 patients. ( 27207567 )
2016
25
A Rare Ocular Manifestation of Adult Onset Still's Disease: Purtscher's-like Retinopathy. ( 27599266 )
2016
26
Intravitreal dexamethasone implants for the treatment of refractory scleritis combined with uveitis in adult-onset Still's disease: a case report. ( 27825329 )
2016
27
Macrophage activation syndrome triggered by disseminated tuberculosis with tuberculous gumma in a patient with adult-onset Still's disease and Good's syndrome. ( 27018416 )
2016
28
Resolution of severe pulmonary arterial hypertension complicating adult-onset Still's disease. ( 27216503 )
2016
29
Macrophage activation syndrome associated with tocilizumab treatment in adult-onset Still's disease. ( 27778518 )
2016
30
Bartonella henselae infection presenting with a picture of adult-onset Still's disease. ( 27000538 )
2016
31
Cytokine profile in adult-onset Still's disease: Comparison with systemic juvenile idiopathic arthritis. ( 27263804 )
2016
32
Pulmonary arterial hypertension secondary to adult-onset Still's disease: Response to cyclosporine and sildenafil over 15 years of follow-up. ( 27408785 )
2016
33
Adult Onset Still's Disease: A Review on Diagnostic Workup and Treatment Options. ( 27042373 )
2016
34
Elevated high-mobility group B1 levels in active adult-onset Still's disease associated with systemic score and skin rash. ( 27225247 )
2016
35
Metabolic Disturbances in Adult-Onset Still's Disease Evaluated Using Liquid Chromatography/Mass Spectrometry-Based Metabolomic Analysis. ( 28005947 )
2016
36
Adult-onset Still's disease-like manifestation accompanied by the cancer recurrence after long-term resting state. ( 27846765 )
2016
37
Pulmonary arterial hypertension in adult onset Still's disease: a case report of a severe complication. ( 27160441 )
2016
38
Efficacy of Low-Dose Tocilizumab on Relapsing Adult-Onset Still's Disease. ( 27131353 )
2016
39
Adult Onset Still's Disease Associated with Mycoplasma pneumoniae Infection and Hemophagocytic Lymphohistiocytosis. ( 27847518 )
2016
40
Combination Immunosuppressive Therapy Including Rituximab for Epstein-Barr Virus-Associated Hemophagocytic Lymphohistiocytosis in Adult-Onset Still's Disease. ( 28018698 )
2016
41
Elevated serum levels of free interleukin-18 in adult-onset Still's disease. ( 27616144 )
2016
42
A retrospective study of patients with adult-onset Still's disease: is pericarditis a possible predictor for biological disease-modifying anti-rheumatic drugs need? ( 26758435 )
2016
43
An atypical presentation of adult-onset Still's disease complicated by pulmonary hypertension and macrophage activation syndrome treated with immunosuppression: a case-based review of the literature. ( 27162622 )
2016
44
Adult Onset Still's Disease With Different Antibodies: A Case Report and Review of Literature. ( 27888598 )
2016
45
Neonatal Haemophagocytic Lymphohistiocytosis Associated with Maternal Adult-Onset Still's Disease. ( 27304999 )
2016
46
Adult-onset Still's disease: Advances in the treatment. ( 27886796 )
2016
47
Limited diagnostic value of procalcitonin in early diagnosis of adult onset Still's disease. ( 27826176 )
2016
48
The role of 18F-fluorodeoxyglucose positron emission tomography in the assessment of disease activity of adult-onset Still's disease. ( 27926812 )
2016
49
Macrophage Activation Syndrome Associated with Adult-Onset Still's Disease Successfully Treated with Anakinra. ( 27818826 )
2016
50
Adult-onset Still's disease with myocarditis and hemophagocytic lymphohistiocytosis: Rare manifestation with fatal outcome. ( 26960645 )
2016

Variations for Adult-Onset Still's Disease

Expression for Adult-Onset Still's Disease

Search GEO for disease gene expression data for Adult-Onset Still's Disease.

Pathways for Adult-Onset Still's Disease

Pathways related to Adult-Onset Still's Disease according to GeneCards Suite gene sharing:

(show top 50) (show all 61)
id Super pathways Score Top Affiliating Genes
1
Show member pathways
13.85 CRP CSF1 IL18 IL1B IL1R1 IL1RN
2
Show member pathways
13.57 CSF1 IL18 IL1B IL1R1 IL6 MIF
3
Show member pathways
13.32 CSF1 IL18 IL1B IL1R1 IL6 TNF
4
Show member pathways
13.29 CSF1 IL18 IL1B IL1R1 IL1RN IL6
5
Show member pathways
13.23 CSF1 IL18 IL1B IL1R1 IL6 TNF
6
Show member pathways
12.81 IL18 IL1B IL1R1 IL1RN IL6 MEFV
7
Show member pathways
12.72 IL18 IL1B IL6 TNF
8
Show member pathways
12.66 IL18 IL1B IL6 TNF
9
Show member pathways
12.63 IL1B IL1R1 IL6 TNF
10
Show member pathways
12.57 IL18 IL1B IL1R1 IL6 TNF
11
Show member pathways
12.54 IL18 IL1B IL6 TNF
12
Show member pathways
12.28 CRP CSF1 IL1B IL6 TNF
13 12.22 IL18 IL1B IL6 TNF
14
Show member pathways
12.21 IL1B IL1R1 IL1RN
15
Show member pathways
12.19 IL1B IL1R1 IL6 MIF TNF
16
Show member pathways
12.18 IL1B IL1R1 IL6 TNF
17 12.17 IL1B IL1RN IL6 TNF
18
Show member pathways
12.16 IL18 IL1B IL6 TNF
19 12.05 CSF1 IL1B IL1R1 TNF
20 12.04 IL1B IL1R1 TNF
21 12.01 IL6 MIF TNF
22 11.98 IL18 IL1B IL6 TNF
23 11.96 CSF1 IL6 TNF
24 11.95 CSF1 IL1B IL6 TNF
25
Show member pathways
11.94 IL18 IL1B IL1R1
26
Show member pathways
11.94 IL18 IL1B IL6 TNF
27
Show member pathways
11.89 IL1B IL1R1 IL6
28 11.88 IL1B IL6 TNF
29 11.87 IL1B IL1R1 IL6 TNF
30 11.85 IL1B IL1R1 TNF
31 11.85 IL1B IL1R1 IL6 MIF TNF
32 11.81 IL18 IL1B IL6
33 11.78 IL18 IL1B IL1R1 TNF
34 11.75 IL1B IL6 TNF
35 11.75 CSF1 IL1B IL6 TNF
36 11.66 IL1B IL6 TNF
37
Show member pathways
11.64 IL1B IL6 MIF TNF
38 11.55 IL18 IL1B IL6 TNF
39 11.54 CSF1 IL1B IL6
40 11.54 CSF1 IL1B IL1R1 IL6 TNF
41 11.51 IL1B IL6 TNF
42
Show member pathways
11.48 IL1B IL1R1 TNF
43 11.47 IL18 IL1B IL6 TNF
44 11.45 IL18 IL1B MEFV
45 11.44 CSF1 IL18 IL1B TNF
46 11.37 IL1B IL6 TNF
47 11.32 IL1B IL6 TNF
48 11.31 CSF1 IL18 IL1B IL6 TNF
49 11.25 IL18 IL1B IL6 TNF
50 11.2 IL18 IL1B IL1R1

GO Terms for Adult-Onset Still's Disease

Cellular components related to Adult-Onset Still's Disease according to GeneCards Suite gene sharing:

id Name GO ID Score Top Affiliating Genes
1 extracellular region GO:0005576 9.61 CRP CSF1 IL18 IL1B IL1R1 IL1RN
2 vesicle GO:0031982 9.33 IL1B IL1RN MIF
3 extracellular space GO:0005615 9.23 CRP CSF1 IL18 IL1B IL1RN IL6

Biological processes related to Adult-Onset Still's Disease according to GeneCards Suite gene sharing:

(show all 42)
id Name GO ID Score Top Affiliating Genes
1 positive regulation of ERK1 and ERK2 cascade GO:0070374 9.86 IL6 MIF TNF
2 positive regulation of protein phosphorylation GO:0001934 9.84 IL1B MIF TNF
3 cytokine-mediated signaling pathway GO:0019221 9.84 IL1B IL1R1 IL6
4 positive regulation of NF-kappaB transcription factor activity GO:0051092 9.83 IL1B IL6 TNF
5 positive regulation of sequence-specific DNA binding transcription factor activity GO:0051091 9.8 IL1B IL6 TNF
6 positive regulation of protein kinase B signaling GO:0051897 9.79 IL18 IL6 TNF
7 cellular response to organic cyclic compound GO:0071407 9.77 IL18 IL1B TNF
8 positive regulation of peptidyl-serine phosphorylation GO:0033138 9.76 IL6 MIF TNF
9 response to glucocorticoid GO:0051384 9.75 IL1RN IL6 TNF
10 defense response to Gram-positive bacterium GO:0050830 9.74 CRP IL6 TNF
11 positive regulation of gene expression GO:0010628 9.72 CRP CSF1 IL1B IL6 TNF
12 positive regulation of smooth muscle cell proliferation GO:0048661 9.71 IL18 IL6 TNF
13 positive regulation of phagocytosis GO:0050766 9.69 IL1B TNF
14 positive regulation of cytokine secretion GO:0050715 9.68 MIF TNF
15 positive regulation of interleukin-8 production GO:0032757 9.68 IL1B TNF
16 osteoclast differentiation GO:0030316 9.68 CSF1 TNF
17 negative regulation of myoblast differentiation GO:0045662 9.67 IL18 TNF
18 positive regulation of osteoclast differentiation GO:0045672 9.67 CSF1 TNF
19 negative regulation of lipid catabolic process GO:0050995 9.66 IL1B TNF
20 positive regulation of chemokine production GO:0032722 9.65 IL6 TNF
21 positive regulation of membrane protein ectodomain proteolysis GO:0051044 9.65 IL1B TNF
22 positive regulation of interferon-gamma production GO:0032729 9.65 IL18 IL1B TNF
23 positive regulation of macrophage derived foam cell differentiation GO:0010744 9.64 CSF1 IL18
24 regulation of I-kappaB kinase/NF-kappaB signaling GO:0043122 9.64 IL1B TNF
25 positive regulation of heterotypic cell-cell adhesion GO:0034116 9.63 IL1B TNF
26 positive regulation of interleukin-6 production GO:0032755 9.63 IL1B IL6 TNF
27 immune response GO:0006955 9.63 IL18 IL1B IL1R1 IL1RN IL6 TNF
28 positive regulation of chemokine biosynthetic process GO:0045080 9.62 IL1B TNF
29 positive regulation of granulocyte macrophage colony-stimulating factor production GO:0032725 9.62 IL18 IL1B
30 positive regulation of T-helper 2 cell differentiation GO:0045630 9.61 IL18 IL6
31 regulation of establishment of endothelial barrier GO:1903140 9.6 IL1B TNF
32 positive regulation of nitric oxide biosynthetic process GO:0045429 9.58 IL1B IL6 TNF
33 epithelial cell proliferation involved in salivary gland morphogenesis GO:0060664 9.56 IL6 TNF
34 positive regulation of fever generation GO:0031622 9.55 IL1B TNF
35 lipopolysaccharide-mediated signaling pathway GO:0031663 9.54 IL18 IL1B TNF
36 sequestering of triglyceride GO:0030730 9.52 IL1B TNF
37 negative regulation of interleukin-1-mediated signaling pathway GO:2000660 9.51 IL1RN IL6
38 positive regulation of chemokine (C-X-C motif) ligand 2 production GO:2000343 9.49 MIF TNF
39 positive regulation of calcidiol 1-monooxygenase activity GO:0060559 9.43 IL1B TNF
40 positive regulation of NF-kappaB import into nucleus GO:0042346 9.43 IL18 IL1B TNF
41 inflammatory response GO:0006954 9.28 CRP CSF1 IL18 IL1B IL1RN IL6
42 negative regulation of lipid storage GO:0010888 9.13 CRP IL6 TNF

Molecular functions related to Adult-Onset Still's Disease according to GeneCards Suite gene sharing:

id Name GO ID Score Top Affiliating Genes
1 cytokine activity GO:0005125 9.17 CSF1 IL18 IL1B IL1RN IL6 MIF
2 interleukin-1 receptor binding GO:0005149 8.96 IL1B IL1RN

Sources for Adult-Onset Still's Disease

3 CDC
7 CNVD
9 Cosmic
10 dbSNP
11 DGIdb
16 ExPASy
18 FMA
28 GO
29 GTR
30 HGMD
31 HMDB
32 HPO
33 ICD10
34 ICD10 via Orphanet
35 ICD9CM
36 IUPHAR
37 KEGG
38 LifeMap
40 MedGen
42 MeSH
43 MESH via Orphanet
44 MGI
46 NCI
47 NCIt
48 NDF-RT
51 NINDS
52 Novoseek
54 OMIM
55 OMIM via Orphanet
59 PubMed
60 QIAGEN
65 SNOMED-CT via Orphanet
67 TGDB
68 Tocris
69 UMLS
70 UMLS via Orphanet
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