AOSD
MCID: ADL030
MIFTS: 59

Adult-Onset Still's Disease (AOSD) malady

Categories: Rare diseases, Nephrological diseases, Bone diseases

Aliases & Classifications for Adult-Onset Still's Disease

About this section
Sources:
11Disease Ontology, 13DISEASES, 30ICD10, 31ICD10 via Orphanet, 39MeSH, 40MESH via Orphanet, 48NIH Rare Diseases, 50Novoseek, 54Orphanet, 62SNOMED-CT, 68UMLS, 69UMLS via Orphanet
See all MalaCards sources

Aliases & Descriptions for Adult-Onset Still's Disease:

Name: Adult-Onset Still's Disease 11 48 13
Adult-Onset Still Disease 11 54 68
Still's Disease, Adult-Onset 39
Still's Disease Adult Onset 48
Adult Onset Still's Disease 11
 
Stills Disease Adult-Onset 50
Wissler-Fanconi Syndrome 54
Adult Still's Disease 48
Wissler's Syndrome 68
Aosd 54

Characteristics:

Orphanet epidemiological data:

54
adult-onset still disease:
Inheritance: Not applicable; Prevalence: 1-9/1000000 (France),1-9/1000000 (Japan),1-9/1000000 (Norway),1-9/100000 (Norway),1-9/100000 (Europe),1-9/1000000 (Turkey),1-9/100000 (Turkey); Age of onset: Adult; Age of death: normal life expectancy

Classifications:



External Ids:

Disease Ontology11 DOID:14256
ICD1030 M06.1
MeSH39 D016706
Orphanet54 ORPHA829
ICD10 via Orphanet31 M06.1
UMLS via Orphanet69 C0085253, C0043195
MESH via Orphanet40 D014924, D016706

Summaries for Adult-Onset Still's Disease

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NIH Rare Diseases:48 Adult-onset still's disease is an inflammatory condition characterized by high fevers, rash, sore throat, and joint pain. as it progresses, adult-onset still's disease may lead to chronic arthritis and other complications. still's disease was named after an english doctor named george still, who described the condition in children in 1896. still's disease which occurs in children (those under the age of 16) is now known as systemic onset juvenile rheumatoid arthritis (jra). in 1971, the term "adult still's disease" was used to describe adults who had a condition similar to systemic onset jra. the cause of adult-onset still's disease is unknown. no risk factors for the disease have been identified. there's no cure for adult-onset still's disease; however, treatment may offer symptom relief and help prevent complications.  last updated: 5/28/2014

MalaCards based summary: Adult-Onset Still's Disease, also known as adult-onset still disease, is related to wissler's syndrome and coloboma of iris, and has symptoms including exanthema, Array and Array. An important gene associated with Adult-Onset Still's Disease is IL18 (Interleukin 18), and among its related pathways are Hypertrophy Model and Transcription factor regulation in adipogenesis. Affiliated tissues include liver, bone and skin, and related mouse phenotypes are Decreased shRNA abundance (Z-score < -2) and neoplasm.

Disease Ontology:11 An arthritis that is a rare from of inflammatory arthritis characterized by fevers, rash, and joint pain.

Related Diseases for Adult-Onset Still's Disease

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Diseases related to Adult-Onset Still's Disease via text searches within MalaCards or GeneCards Suite gene sharing:

(show top 50)    (show all 230)
idRelated DiseaseScoreTop Affiliating Genes
1wissler's syndrome11.1
2coloboma of iris10.3CRP, IL6
3vps11-related autosomal recessive hypomyelinating leukodystrophy10.3IL6, TNF
4neutrophilia, hereditary10.2CRP, IL6
5dyslexia 510.2IL6, TNF
6aortic atherosclerosis10.2IL6, TNF
7degenerative disc disease10.2IL6, TNF
8cardiac tuberculosis10.2CRP, IL6
9thymic neuroendocrine carcinoma10.2IL6, TNF
10psoriatic arthritis10.2IL18, TNF
11drug dependence10.2IL6, TNF
12myeloid neoplasms associated with pdgfrb rearrangement10.2MEFV, TNF
13fanconi syndrome10.2
14cataract, total congenital10.2CRP, IL6
15allergic bronchopulmonary aspergillosis10.2CRP, IL18, IL6
16candidiasis, familial, 4, autosomal recessive10.2MEFV, TNF
17fallopian tube adenomatoid tumor10.2CRP, IL1RN
18transient tic disorder10.2IL6, TNF
19immunodeficiency 910.2CRP, IL1RN
20papilledema10.2IL6, TNF
21angiomatosis, diffuse corticomeningeal, of divry and van bogaert10.2IL6, TNF
22lacrimal system cancer10.2CRP, IL18, IL6
23unilateral multicystic dysplastic kidney10.2CRP, IL6, TNF
24intussusception10.2IL1B, TNF
25swine influenza10.2CRP, IL6, TNF
26red cell phospholipid defect with hemolysis10.2IL18, IL6, TNF
27joint disorders10.2CRP, IL6, TNF
28cicatricial lagophthalmos10.2CRP, IL6, TNF
29oculomotor nerve paralysis10.2IL1B, IL6
30autoimmune disease of central nervous system10.1CRP, IL6, TNF
31common peroneal nerve lesion10.1IL1B, IL6
32plummer's disease10.1CRP, IL6, TNF
33nemaline myopathy 1, autosomal dominant or recessive10.1IL1RN, TNF
34follicular adenoma10.1CRP, IL6, TNF
35carotenemia10.1CRP, IL6, TNF
36retinitis pigmentosa 5110.1CRP, IL6, TNF
37bile duct signet ring cell carcinoma10.1CRP, IL1R1, TNF
38chondroma10.1CRP, IL6, TNF
39amelogenesis imperfecta10.1CRP, IL6, TNF
40functional gastric disease10.1CRP, IL1R1, TNF
41esotropia10.1CRP, IL6, MEFV
42asbestosis10.1CRP, IL6, TNF
43limb ischemia10.1CRP, IL6, TNF
44tetanus10.1MEFV, TNF
45neonatal jaundice10.1IL18, IL6, TNF
46pemphigus vulgaris, familial10.1CRP, IL6, TNF
47familial nephrotic syndrome10.1CRP, IL6, TNF
48diabetic encephalopathy10.1CRP, IL6, TNF
49primary ciliary dyskinesia10.1IL1R1, IL6, TNF
50neovascular glaucoma10.1CRP, IL6, TNF

Graphical network of the top 20 diseases related to Adult-Onset Still's Disease:



Diseases related to adult-onset still's disease

Symptoms & Phenotypes for Adult-Onset Still's Disease

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Human phenotypes related to Adult-Onset Still's Disease:

 54 64 (show all 29)
id Description HPO Frequency Orphanet Frequency HPO Source Accession
1 skin rash64 54 Very frequent (99-80%) HP:0000988
2 pruritus64 54 Very frequent (99-80%) HP:0000989
3 meningitis64 54 Occasional (29-5%) HP:0001287
4 arthritis64 54 Very frequent (99-80%) HP:0001369
5 joint swelling64 54 Very frequent (99-80%) HP:0001386
6 pericarditis64 54 Frequent (79-30%) HP:0001701
7 splenomegaly64 54 Very frequent (99-80%) HP:0001744
8 fever64 54 Very frequent (99-80%) HP:0001945
9 leukocytosis64 54 Very frequent (99-80%) HP:0001974
10 abdominal pain64 54 Frequent (79-30%) HP:0002027
11 restrictive lung disease54 Very frequent (99-80%)
12 pleuritis64 54 Frequent (79-30%) HP:0002102
13 hepatomegaly64 54 Very frequent (99-80%) HP:0002240
14 arthralgia64 54 Very frequent (99-80%) HP:0002829
15 elevated hepatic transaminases64 54 Occasional (29-5%) HP:0002910
16 abnormality of lipid metabolism64 54 Occasional (29-5%) HP:0003119
17 myalgia64 54 Frequent (79-30%) HP:0003326
18 elevated erythrocyte sedimentation rate64 54 Very frequent (99-80%) HP:0003565
19 bone marrow hypocellularity64 54 Occasional (29-5%) HP:0005528
20 generalized lymphadenopathy64 54 Frequent (79-30%) HP:0008940
21 erythema64 54 Very frequent (99-80%) HP:0010783
22 elevated c-reactive protein level64 54 Very frequent (99-80%) HP:0011227
23 neutrophillia64 54 Very frequent (99-80%) HP:0011897
24 hepatitis64 54 Occasional (29-5%) HP:0012115
25 fatigue64 54 Very frequent (99-80%) HP:0012378
26 myocarditis64 54 Occasional (29-5%) HP:0012819
27 cartilage destruction64 54 Occasional (29-5%) HP:0100773
28 recurrent pharyngitis64 54 Occasional (29-5%) HP:0100776
29 restrictive ventilatory defect64 HP:0002091

UMLS symptoms related to Adult-Onset Still's Disease:


exanthema

GenomeRNAi Phenotypes related to Adult-Onset Still's Disease according to GeneCards Suite gene sharing:

26
idDescriptionGenomeRNAi Source AccessionScoreTop Affiliating Genes
1GR00366-A-848.2CSF1, IL1B, IL1R1, MIF

MGI Mouse Phenotypes related to Adult-Onset Still's Disease according to GeneCards Suite gene sharing:

41
idDescriptionMGI Source AccessionScoreTop Affiliating Genes
1MP:00020068.7IL1B, IL1R1, IL6, MIF, TNF
2MP:00053708.0CSF1, IL1R1, IL6, MEFV, TNF
3MP:00053907.3CSF1, IL1B, IL1R1, IL1RN, IL6, MEFV
4MP:00053857.1CRP, CSF1, IL18, IL1B, IL1R1, IL1RN
5MP:00053846.9CSF1, IL18, IL1R1, IL1RN, IL6, MEFV
6MP:00107716.8CSF1, IL18, IL1B, IL1R1, IL1RN, IL6
7MP:00053976.3CSF1, IL18, IL1B, IL1R1, IL1RN, IL6
8MP:00053766.1CRP, CSF1, IL18, IL1B, IL1R1, IL1RN
9MP:00053876.0CRP, CSF1, IL18, IL1B, IL1R1, IL1RN

Drugs & Therapeutics for Adult-Onset Still's Disease

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Drugs for Adult-Onset Still's Disease (from DrugBank, HMDB, Dgidb, PharmGKB, IUPHAR, NovoSeek, BitterDB):

(show all 27)
idNameStatusPhaseClinical TrialsCas NumberPubChem Id
1
MethotrexateapprovedPhase 215511959-05-2, 59-05-2126941
Synonyms:
4-amino-10-methylfolic acid
4-amino-N(10)-methylpteroylglutamic acid
Abitrexate
Amethopterin
Amethopterine
Antifolan
Arbitrexate
Emtexate
Folex
HDMTX
L-Amethopterin
Ledertrexate
MTX
Metatrexan
 
Methopterin
Methotextrate
Methotrate
Methotrexat
Methotrexate Sodium
Methotrexatum
Methylaminopterin
Methylaminopterinum
Metotrexato
Mexate
Méthotrexate
N-Bismethylpteroylglutamic Acid
N-[4-[[(2,4-diamino-6-pteridinyl)methyl]methylamino]benzoyl]-L-glutamic acid
Rheumatrex
Trexall
2
Methylprednisoloneapproved, vet_approvedPhase 2119383-43-26741
Synonyms:
(6S,8S,9S,10R,11S,13S,14S,17R)-11,17-dihydroxy-17-(2-hydroxyacetyl)-6,10,13-trimethyl-7,8,9,11,12,14,15,16-octahydro-6H-cyclopenta[a]phenanthren-3-one
(6a,11b)-11,17,21-Trihydroxy-6-methylpregna-1,4-diene-3,20-dione
(6alpha,11beta)-11,17,21-Trihydroxy-6-methylpregna-1,4-diene-3,20-dione
(6α,11β)-11,17,21-trihydroxy-6-methylpregna-1,4-diene-3,20-dione
.DELTA.1-6.alpha.-Methylhydrocortisone
1-Dehydro-6alpha-methylhydrocortisone
1-dehydro-6alpha-Methylhydrocortisone
1-dehydro-6α-methylhydrocortisone
11-beta,17,21-Trihydroxy-6-alpha-methylpregna-1,4-diene-3,20-dione
11beta,17,21-Trihydroxy-6alpha-methylpregna-1,4-diene-3,20-dione
11beta,17alpha,21-Trihydroxy-6alpha-methyl-1,4-pregnadiene-3,20-dione
11beta,17alpha,21-Trihydroxy-6alpha-methylpregna-1,4-diene-3,20-dione
121673-01-6
4-08-00-03498 (Beilstein Handbook Reference)
46436_FLUKA
46436_RIEDEL
570-35-4
6 Methylprednisolone
6-Methylprednisolone
6-alpha-Methylprednisolone
6.alpha.-Methylprednisolone
6923-42-8
6alpha-Methyl-11beta,17alpha,21-trihydroxy-1,4-pregnadiene-3,20-dione
6alpha-Methyl-11beta,17alpha,21-triol-1,4-pregnadiene-3,20-dione
6alpha-Methylprednisolone
6alpha-methyl-11beta,17alpha,21-triol-1,4-pregnadiene-3,20-dione
83-43-2
AC1L1N7A
Artisone-Wyeth
Artisone-wyeth
BPBio1_000174
BRD-K35240538-001-03-1
BRN 2340300
BSPBio_000158
Besonia
Bio-0658
CHEBI:6888
CHEMBL650
CID6741
CPD000058330
D00407
D008775
DB00959
Depo-Medrol (acetate)
Dopomedrol
EINECS 201-476-4
Esametone
Firmacort
HMS1568H20
HMS2090B13
HSDB 3127
LMST02030178
LS-118498
Lemod
M0639_SIGMA
M1665
MEPRDL
MLS000028541
MLS001148159
MLS002207191
Medesone
Medixon
Medlone 21
 
Medrate
Medrol
Medrol (TN)
Medrol Adt Pak
Medrol Dosepak
Medrol adt pak
Medrol dosepak
Medrol, Solu-Medrol, Medrone, Methylprednisolone
Medrone
Mesopren
Metastab
Methyleneprednisolone
Methylprednisolon
Methylprednisolone
Methylprednisolone (JP15/USP/INN)
Methylprednisolone [USAN:INN:BAN:JAN]
Methylprednisolone, 6-alpha
Methylprednisolonum
Methylprednisolonum [INN-Latin]
Metilbetasone
Metilprednisolona
Metilprednisolona [INN-Spanish]
Metilprednisolone
Metilprednisolone [DCIT]
Metilprednisolone [Dcit]
Metipred
Metrisone
Metrocort
Metysolon
Moderin
MolPort-002-528-554
NCGC00022735-03
NCI60_001657
NSC-19987
NSC19987
Nirypan
Noretona
Predni N Tablinen
Prednol- L
Pregna-1,4-diene-3,20-dione, 11beta,17,21-trihydroxy-6alpha-methyl- (8CI)
Prestwick0_000279
Prestwick1_000279
Prestwick2_000279
Prestwick3_000279
Prestwick_622
Promacortine
Reactenol
S1733_Selleck
SAM002589984
SMR000058330
SPBio_002377
Sieropresol
Solomet
Summicort
Suprametil
U 7532
UNII-X4W7ZR7023
Urbason
Urbasone
Wyacort
ZINC03875560
delta(1)-6alpha-Methylhydrocortisone
delta(sup 1)-6-alpha-Methylhydrocortisone
methylprednisolone
methylprenisolone
3
Prednisoloneapproved, vet_approvedPhase 2119350-24-85755
Synonyms:
(11beta)-11,17,21-Trihydroxypregna-1,4-diene-3,20-dione
.DELTA.1-Cortisol
.DELTA.1-Dehydrocortisol
.DELTA.1-Dehydrohydrocortisone
.DELTA.1-Hydrocortisone
.delta.-Cortef
.delta.-Stab
1,2-Dehydrohydrocortisone
1,4-Pregnadiene-11beta,17alpha,21-triol-3,20-dione
1,4-Pregnadiene-3,20-dione-11beta,17alpha,21-triol
1-Dehydrocortisol
1-Dehydrohydrocortisone
3,20-dioxo-11beta,17alpha,21-Trihydroxy-1,4-pregnadiene
46656_FLUKA
46656_RIEDEL
50-24-8
58201-11-9
8056-11-9
AC-1773
AC1L1L2E
Ak-Pred
Ak-Tate
Alphadrol
Articulose-50
BPBio1_000164
BRD-K98039984-001-03-0
BRN 1354103
BSPBio_000148
Bio-0666
Bubbli-Pred
C07369
CCRIS 980
CHEBI:8378
CHEMBL131
CID5755
CO-Hydeltra
CPD000718761
Co-Hydeltra
Codelcortone
Cordrol
Cortalone
Cotogesic
Cotolone
D00472
D011239
DB00860
Decaprednil
Decortin H
Delcortol
Delta F
Delta(1)-dehydrohydrocortisone
Delta-Cortef
Delta-Cortef (TN)
Delta-Ef-Cortelan
Delta-Stab
Delta-stab
Deltacortenol
Deltacortril
Deltacortril Enteric
Deltahydrocortisone
Deltasolone
Deltisilone
Depo-Medrol
Derpo PD
Derpo Pd
Dexa-Cortidelt Hostacortin H
Dexa-Cortidelt hostacortin H
Di Adreson F
Di-Adreson F
Di-Adreson-F
Di-adreson F
DiAdresonF
Dicortol
Donisolone
Dydeltrone
EINECS 200-021-7
Eazolin D
Econopred
Econopred Plus
Erbacort
Erbasona
Estilsona
Fernisolone
Fernisolone P
Fernisolone-P
Flamasone
HMS1568H10
HMS2090J05
HSDB 3385
Hostacortin H
Hydeltra
Hydeltra-Tba
Hydeltrasol
Hydeltrone
Hydrodeltalone
Hydrodeltisone
Hydroretrocortin
Hydroretrocortine
I-Pred
Inflamase Forte
Inflamase Mild
K 1557
Key-Pred
Klismacort
LMST02030179
LS-7669
Lentosone
Lite Pred
M-Predrol
 
MLS001304083
MLS002154250
MLS002207037
Medrol
Medrol Acetate
Metacortandralone
Methylprednisolone Acetate
Meti-Derm
Meticortelone
Metreton
MolPort-002-507-147
NCGC00179649-01
NSC 9120
NSC9120
NSC9900
Neo-Delta-Cortef
Nisolone
Nor-Pred T.B.A.
Ocu-Pred
Ocu-Pred Forte
Ophtho-Tate
Orapred
P0152_SIGMA
P0637
P6004_SIGMA
PRDL
PRED-G
Panafcortelone
Paracortol
Paracotol
Pediapred
Poly-Pred
Precortalon
Precortancyl
Precortilon
Precortisyl
Pred Forte
Pred Mild
Predair
Predair A
Predair Forte
Predalone 50
Predalone T.B.A.
Predate
Predate Tba
Predate-50
Predcor-25
Predcor-50
Predcor-Tba
Predisolone Sodium Phosphate
Predne-Dome
Prednelan
Predni-Dome
Prednicen
Predniliderm
Predniretard
Prednis
Prednisolona
Prednisolona [INN-Spanish]
Prednisolone (JP15/USP/INN)
Prednisolone (anhydrous)
Prednisolone Acetate
Prednisolone Sodium Phosphate
Prednisolone Tebutate
Prednisolone [INN:BAN:JAN]
Prednisolonum
Prednisolonum [INN-Latin]
Predonin
Predonine
Prelone
Prenolone
Prestwick0_000274
Prestwick1_000274
Prestwick2_000274
Prestwick3_000274
Prestwick_404
Rolisone
S1737_Selleck
SAM002264639
SMR000718761
SPBio_002367
Scherisolon
Solone
Steran
Sterane
Sterolone
Supercortisol
UNII-9PHQ9Y1OLM
Ulacort
Ultra Pred
Ultracorten H
Ultracortene H
Ultracortene-H
Ultracortene-Hydrogen
Ultracortene-hydrogen
ZINC03833821
component of Ataraxoid
component of K-Predne-Dome
delta(1)-Cortisol
delta(1)-Dehydrocortisol
delta(1)-Dehydrohydrocortisone
delta(1)-Hydrocortisone
delta(sup 1)-Cortisol
delta(sup 1)-Dehydrocortisol
delta(sup 1)-Dehydrohydrocortisone
delta(sup 1)-Hydrocortisone
delta-dehydrocortisol
delta-dehydrohydrocortisone
delta-hydrocortisone
prednisolone
4
AzathioprineapprovedPhase 2177446-86-62265
Synonyms:
446-86-6
55774-33-9 (hydrochloride salt)
6-((1-Methyl-4-nitro-1H-imidazol-5-yl)thio)-1H-purine
6-((1-Methyl-4-nitroimidazol-5-yl)thio)purine
6-(1'-Methyl-4'-nitro-5'-imidazolyl)-mercaptopurine
6-(1'-Methyl-4'-nitro-5'-imidazolyl)mercaptopurine
6-(1-Methyl-4-nitroimidazol-5-yl)thiopurine
6-(1-Methyl-4-nitroimidazol-5-ylthio)purin
6-(1-Methyl-4-nitroimidazol-5-ylthio)purin [Czech]
6-(1-Methyl-p-nitro-5-imidazolyl)-thiopurine
6-(1-Methyl-p-nitro-5-imidazolyl)thiopurine
6-(3-Methyl-5-nitro-3H-imidazol-4-ylsulfanyl)-7H-purine
6-(3-methyl-5-nitroimidazol-4-yl)sulfanyl-7H-purine
6-(Methyl-p-nitro-5-imidazolyl)-thiopurine
6-(Methyl-p-nitro-5-imidazolyl)thiopurine
6-({4-nitro-1-methyl-1H-imidazol-5-yl}sulfanyl)-7H-purine
6-1'-Methyl,4'-nitro,5'-imidazolyl mercaptopurine
6-[(1-Methyl-4-nitroimidazol-5-yl)- thio] purine
6-[(1-Methyl-4-nitroimidazol-5-yl)thio]purine
6-[(1-methyl-4-nitro-1H-imidazol-5-yl)sulfanyl]-7H-purine
6-[(1-methyl-4-nitro-1H-imidazol-5-yl)thio]-1H-Purine
6-[(1-methyl-4-nitro-1H-imidazol-5-yl)thio]-7H-purine
6-[(1-methyl-4-nitro-1H-imidazol-5-yl)thio]-9H-purine
A 4638
A2593_SIAL
A4638_SIAL
A4638_SIGMA
AB00443544
AB00443544-03
AC-4230
AC1L1DAL
AC1Q3Z1F
AI-981/34845012
AI3-50290
Azamun
Azamun [Czech]
Azanin
Azasan
Azasan (TN)
Azasan, Imuran, Azamun, BW-57-322, NSC-39084, Azathioprine
Azathioprin
Azathioprine (JP15/USP/INN)
Azathioprine Sodium
Azathioprine [USAN:INN:BAN:JAN]
Azathioprine sodium
Azathioprinum
Azathioprinum [INN-Latin]
Azathiopurine
Azatioprin
Azatioprina
Azatioprina [INN-Spanish]
Azothioprine
B. W. 57-322
BPBio1_000054
BRD-K32821942-001-05-6
BRD-K60324116-001-01-5
BSPBio_000048
BSPBio_001876
BW 57-322
BW 57322
BW-57-322
C06837
C9H7N7O2S
CAS-446-86-6
CBDivE_013132
CCRIS 62
CHEBI:2948
CHEMBL1542
CID2265
CPD000427366
Ccucol
ChemDiv1_002659
Cytostatics
D00238
DB00993
DivK1c_000586
EINECS 207-175-4
EU-0100027
FT-0083532
HMS1568C10
HMS1920E17
 
HMS2091K19
HMS501N08
HMS594I19
HSDB 7084
IDI1_000586
Immuran
Imuran
Imuran (TN)
Imuran (tn)
Imurek
Imurel
KBio1_000586
KBio2_000464
KBio2_002427
KBio2_003032
KBio2_004995
KBio2_005600
KBio2_007563
KBio3_001376
KBio3_002906
KBioGR_000646
KBioGR_002427
KBioSS_000464
KBioSS_002433
LS-123
Lopac-A-4638
Lopac0_000027
MLS001049307
Methylnitroimidazolylmercaptopurine
MolPort-000-745-914
MolPort-000-764-262
MolPort-003-665-485
Muran
NCGC00015060-01
NCGC00015060-02
NCGC00015060-04
NCGC00015060-12
NCGC00090836-01
NCGC00090836-02
NCGC00090836-03
NCGC00090836-04
NCGC00090836-05
NCGC00090836-06
NCGC00094593-01
NCGC00094593-02
NCGC00094593-03
NCI-C03474
NINDS_000586
NSC 39084
NSC-39084
NSC39084
Oprea1_375441
Oprea1_533384
Oprea1_633462
Prestwick0_000094
Prestwick1_000094
Prestwick2_000094
Prestwick3_000094
Prestwick_41
S1721_Selleck
SAM002589938
SDCCGMLS-0065415.P001
SMR000427366
SPBio_000255
SPBio_001987
SPECTRUM1500133
STK831906
STOCK1S-20293
STOCK1S-27186
Spectrum2_000068
Spectrum3_000308
Spectrum4_000243
Spectrum5_000848
Spectrum_000064
Thiopurine 6-(1-methyl-4-nitroimidazol-5-yl)
UNII-MRK240IY2L
WLN: T56 BM DN FN HNJ IS- ET5N CNJ A1 DNW
ZINC04258316
[Methyl(nitroimidazolyl)mercaptopurine]
azathioprine
azatiopr in
cMAP_000046
5
Leflunomideapproved, investigationalPhase 26775706-12-63899
Synonyms:
210165-51-8
4-Isoxazolecarboxamide, 5-methyl-N-(4-(trifluoromethyl)phenyl
4-isoxazolecarboxamide,5-methyl-N-(4-(trifluoromethyl)phenyl)
5-Methyl-N-(4-(trifluoromethyl)phenyl)-4-isoxazolecarboxamide
5-Methylisoxazole-4-(4-trifluoromethyl)carboxanilide
5-Methylisoxazole-4-(4-trifluoromethylcarboxanilide)
5-Methylisoxazole-4-carboxylic acid (4-trifluoromethyl)anilide
5-methyl-N-[4-(trifluoromethyl)phenyl]-1,2-oxazole-4-carboxamide
5-methyl-N-[4-(trifluoromethyl)phenyl]-4-isoxazolecarboxamide
5-methyl-N-[4-(trifluoromethyl)phenyl]isoxazole-4-carboxamide
75706-12-6
A77 1486
AB00052389
AC-6796
AC1L1GYK
AC1Q2EVA
AKOS000265193
AP-501/42475599
Arava
Arava (TN)
Arava, Leflunomide
Aventis Behring Brand of Leflunomide
Aventis Brand of Leflunomide
Aventis Pharma Brand of Leflunomide
BIDD:PXR0189
BPBio1_000930
BRD-K78692225-001-03-9
BSPBio_000844
C045463
C07905
CAS-75706-12-6
CHEBI:6402
CHEMBL960
CID3899
D00749
DB01097
DivK1c_000916
EU-0100649
HMS1570K06
HMS1922M06
HMS2090O12
HMS502N18
HSDB 7289
HWA 486
HWA-486
Hoechst Brand of Leflunomide
I06-2131
IDI1_000916
KBio1_000916
KBio2_000802
KBio2_003370
KBio2_005938
KBioSS_000802
L 5025
L5025_SIGMA
 
LS-86580
Leflunomid
Leflunomida
Leflunomida [INN-Spanish]
Leflunomide
Leflunomide (JAN/USAN/INN)
Leflunomide [USAN:INN]
Leflunomidum
Leflunomidum [INN-Latin]
Lefunomide
Lefunomide [INN-Spanish]
Lefunomide [Inn-Spanish]
Lopac-L-5025
Lopac0_000649
MLS-0003109.0001
MLS000069648
MLS001076267
MolPort-002-345-613
N-(4'-Trifluoromethylphenyl)-5-methylisoxazole-4-carboxamide
N-(4-trifluoromethyphenyl)-5-methylisoxazole-4-carboxamide
NCGC00015610-01
NCGC00015610-02
NCGC00015610-03
NCGC00015610-07
NCGC00015610-12
NCGC00022625-03
NCGC00022625-04
NCGC00022625-05
NCGC00022625-06
NCGC00022625-07
NCGC00022625-08
NINDS_000916
NSC677411
Prestwick0_000772
Prestwick1_000772
Prestwick2_000772
Prestwick3_000772
Prestwick_87
RS-34821
S1247_Selleck
SMR000058209
SPBio_002783
SPECTRUM1503927
SU 101
SU 101 (pharmaceutical)
SU-101
SU101
Spectrum5_000850
Spectrum_000322
TL8005179
UNII-G162GK9U4W
ZINC00004840
alpha,alpha,alpha-Trifluoro-5-methyl-4-isoxazolecarboxy-P-toluidide
alpha,alpha,alpha-Trifluoro-5-methyl-4-isoxazolecarboxy-p-toluidide
leflunomide
lefunamide
6
Folic Acidapproved, nutraceutical, vet_approvedPhase 2439259-30-36037
Synonyms:
(2S)-2-[[4-[(2-amino-4-oxo-1H-pteridin-6-yl)methylamino]benzoyl]amino]pentanedioic acid
01769_FLUKA
2d0k
33609-88-0
36653-55-1 (mono-potassium salt)
59-30-3
6484-89-5 (mono-hydrochloride salt)
AC-11682
AC1L1LNX
AI3-26387
AKOS000503224
ARONIS014410
Acfol (Spain)
Acide folique
Acide folique [INN-French]
Acido folico
Acido folico [INN-Spanish]
Acidum folicum
Acidum folicum [INN-Latin]
Acifolic
Antianemia factor
Apo-Folic
BIDD:ER0563
BIDD:GT0641
BIF0608
BPBio1_000654
BSPBio_000594
BSPBio_002338
C00504
C20H20N6O6
CAS-59-30-3
CCRIS 666
CHEBI:27470
CHEMBL1622
CID6037
CPD000471860
Cytofol
D00070
DB00158
DivK1c_000494
Dosfolat B activ
EINECS 200-419-0
F0043
F7876_SIAL
F7876_SIGMA
F8758_SIGMA
F8798_SIAL
F8890_SIGMA
FOL
Facid
Factor U
Folacid
Folacin
Folaemin
Folaemin [Netherlands]
Folan
Folasic (Australia)
Folate
Folbal
Folcidin
Folcidin (VAN)
Folcysteine
Foldine
Foldine [France]
Folettes
Foliamin
Folic
Folic acid
Folic acid (JP15/USP/INN)
Folic acid (TN)
Folic acid [BAN:INN:JAN]
Folic acid [INN:BAN:JAN]
Folic acid dihydrate
Folicet
Folicet (TN)
Folico
Folico (Italy)
Folina
Folina (Italy)
Folipac
Folsaeure
 
Folsan
Folsaure
Folsav
Folvite
Folvron
Glutamic acid, N-(p-(((2-amino-4-hydroxypyrimido(4,5-b)pyrazin-6-yl)methyl)amino)benzoyl)-, L
HMS1921D20
HMS2092N17
HMS501I16
HSDB 2002
IDI1_000494
InChI=1/C19H19N7O6/c20-19-25-15-14(17(30)26-19)23-11(8-22-15)7-21-10-3-1-9(2-4-10)16(29)24-12(18(31)32)5-6-13(27)28/h1-4,8,12,21H,5-7H2,(H,24,29)(H,27,28)(H,31,32)(H3,20,22,25,26,30)/t12-/m0/s
Incafolic
KBio1_000494
KBio2_001861
KBio2_004429
KBio2_006997
KBio3_001558
KBioGR_002222
KBioSS_001861
Kyselina listova
Kyselina listova [Czech]
LS-2157
Liver Lactobacillus casei factor
MLS001304016
MLS001335861
Millafol
Mission prenatal
Mittafol
MolPort-004-285-551
N-(4-(((2-Amino-1,4-dihydro-4-oxo-6-pteridinyl)methyl)amino)benzo- yl)-L-glutamic acid
N-(4-((2-Amino-1,4-dihydro-4-oxo-6-pteridinyl)methyl)amino)benzoyl)-L-glutamic acid
N-(4-{[(2-Amino-4-oxo-3,4-dihydropteridin-6-yl)methyl]amino}benzoyl)-L-glutamic acid
N-(4-{[(2-amino-4-oxo-1,4-dihydropteridin-6-yl)methyl]amino}benzoyl)-L-glutamic acid
N-(p-(((2-Amino-4-hydroxy-6-pteridinyl)methyl)amino)benzoyl)-L-glutamic acid
N-Pteroyl-L-glutamic acid
N-[(4-{[(2-Amino-4-oxo-1,4-dihydropteridin-6-yl)methyl]amino}phenyl)carbonyl]-L-glutamic acid
N-[(4-{[(2-amino-4-oxo-1,4-dihydropteridin-6-yl)methyl]amino}phenyl)carbonyl]-L-glutamic acid
N-[4-[[(2-Amino-3,4-dihydro-4-oxo-6-pteridinyl)methyl]amino]benzoyl]-L-glutamic acid
NCGC00016265-01
NCGC00142391-01
NINDS_000494
NSC 3073
Nifolin
Nifolin [Denmark]
Novofolacid
Novofolacid [Canada]
PGA
PGA (VAN)
Prestwick3_000627
Prestwick_230
PteGlu
Pteroyl-L-glutamate
Pteroyl-L-glutamic acid
Pteroyl-L-monoglutamate
Pteroyl-L-monoglutamic acid
Pteroylglutamate
Pteroylglutamic acid
Pteroylmonoglutamate
Pteroylmonoglutamic acid
SAM002264616
SDCCGMLS-0066738.P001
SMP2_000137
SMR000471860
SPBio_001357
SPECTRUM1502020
Serum Folate Level
Spectrum2_001459
Spectrum3_000749
Spectrum4_001751
Spectrum5_000602
Spectrum_001381
UNII-935E97BOY8
Usaf cb-13
Vitamin B11
Vitamin B9
Vitamin Bc
Vitamin Be
Vitamin M
bmse000299
folic acid
nchembio.108-comp10
7
leucovorinapproved, NutraceuticalPhase 2323558-05-954575, 6560146, 143
Synonyms:
(5-formyl-5,6,7,8-tetrahydropteroyl)glutamate
(6R,S)-5-Formyltetrahydrofolate
10-Formyl-7,8-dihydrofolate
10-Formyl-7,8-dihydrofolic acid
5-Formyl-5,6,7,8-tetrahydrofolate
5-Formyl-5,6,7,8-tetrahydrofolic acid
5-Formyl-5,6,7,8-tetrahydropteroyl-L-glutamic acid
5-Formyltetrahydrofolate
5-Formyltetrahydrofolic acid
5-Formyltetrahydropteroylglutamate
5-Formyltetrahydropteroylglutamic acid
5-formyltetrahydrofolic acid
Acide folinique
Calcium citrovorum factor
Calcium folinate
Citrovorum factor
Folinate
Folinic acid
Folinic acid calcium salt
 
Folinic acid calcium salt USP27
Folinic acid-SF
L(-)-5-Formyl-5,6,7,8-tetrahydrofolic acid
L-Leucovorin
L-N-[p-[[(2-Amino-5-formyl-5,6,7,8-tetrahydro-4-hydroxy-6-pteridinyl)methyl]amino]benzoyl]-Glutamic acid
L-leucovorin
Leucal
Leucovorin calcium
Leucovorin folinic acid
Leucovorinum
Leukovorin
Levoleucovorin
N-(5-formyl-5,6,7,8-tetrahydropteroyl)-L-glutamic acid
N5-Formyl-5,6,7,8-tetrahydrofolate
N5-Formyl-5,6,7,8-tetrahydrofolic acid
N5-Formyl-THF
N5-Formyltetrahydrofolate
N5-Formyltetrahydrofolic acid
Welcovorin
Wellcovorin
folinate
8Antibodies, MonoclonalPhase 24039
9ImmunoglobulinsPhase 26394
10AntibodiesPhase 26394
11Nucleic Acid Synthesis InhibitorsPhase 24962
12Prednisolone hemisuccinatePhase 21193
13Chelating AgentsPhase 21423
14Vitamin B ComplexPhase 24337
15Prednisolone phosphatePhase 21193
16Methylprednisolone HemisuccinatePhase 21193
17Prednisolone acetatePhase 21193
18AntimetabolitesPhase 212054
19Dermatologic AgentsPhase 25806
20Antimetabolites, AntineoplasticPhase 27361
21Methylprednisolone acetatePhase 21193
22Folic Acid AntagonistsPhase 22257
23Antirheumatic AgentsPhase 210956
24Immunosuppressive AgentsPhase 213086
25Interleukin 1 Receptor Antagonist ProteinPhase 299
26FolateNutraceuticalPhase 24392
27Vitamin B9NutraceuticalPhase 24392

Interventional clinical trials:

idNameStatusNCT IDPhase
1Efficacy and Safety of Tocilizumab in Adult's Still DiseaseUnknown statusNCT01002781Phase 2
2Treatment of Refractory Adult-onset Still's Disease With Anakinra: a Randomized StudyCompletedNCT01033656Phase 2
3Therapeutic Use of Tadekinig Alfa in Adult-onset Still's DiseaseCompletedNCT02398435Phase 2
4Interleukin-1 Trap to Treat Autoinflammatory DiseasesCompletedNCT00094900Phase 2
5The Empowerment Model Towards Type 2 Diabetic Adults To Enhance Vegetable Intake in Achieving Glycemic ControlCompletedNCT01828242Phase 2
6Canakinumab for Treatment of Adult Onset Still's DiseaseRecruitingNCT02204293Phase 2
7Tocilizumab in Patients With Schnitzler's SyndromeNot yet recruitingNCT03046381Phase 2
8Glycosylated Ferritin in Macrophagic Activation SyndromesRecruitingNCT02143986

Search NIH Clinical Center for Adult-Onset Still's Disease


Cochrane evidence based reviews: still's disease, adult-onset

Genetic Tests for Adult-Onset Still's Disease

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Anatomical Context for Adult-Onset Still's Disease

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MalaCards organs/tissues related to Adult-Onset Still's Disease:

36
Liver, Bone, Skin, Lung, Lymph node, T cells, Bone marrow

Publications for Adult-Onset Still's Disease

About this section

Articles related to Adult-Onset Still's Disease:

(show top 50)    (show all 608)
idTitleAuthorsYear
1
Rumpel-Leede phenomenon in a patient with adult-onset Still's disease. (28130282)
2017
2
Unusual manifestations and unusual mimics of adult onset Still's disease. (28397955)
2017
3
Hemophagocytic lymphohistiocytosis with high serum levels of IL-18 and predominant lymphocyte activation in a neonate born to a mother with adult-onset Still's disease. (28450255)
2017
4
Adult-onset Still's disease with atypical cutaneous manifestations. (28296747)
2017
5
Serum Levels of Interleukin 33 and Soluble ST2 Are Associated with the Extent of Disease Activity and Cutaneous Manifestations in Patients with Active Adult-onset Still's Disease. (28365573)
2017
6
Adult-Onset Still's Disease: Still a Serious Health Problem (a Case Report and Literature Review). (28154368)
2017
7
Phosphorylated signal transducer and activator of transcription 3 in the epidermis in adult-onset Still's disease. (28470759)
2017
8
New Markers for Adult-Onset Still's Disease. (28529117)
2017
9
Elevated circulating levels of the interferon-I^-induced chemokines are associated with disease activity and cutaneous manifestations in adult-onset Still's disease. (28436448)
2017
10
Highly Expression of CD11b and CD32 on Peripheral Blood Mononuclear Cells from Patients with Adult-Onset Still's Disease. (28106835)
2017
11
Inadvertent Skipping of Steroids in Septic Shock Leads to a Diagnosis of Adult Onset Still's Disease. (28191382)
2017
12
Epidemiological study of adult-onset Still's disease using a Japanese administrative database. (27502500)
2016
13
Adult onset Still's disease with dermatopathic lymphadenopathy. (27761568)
2016
14
Adult-onset Still's disease: current challenges and future prospects. (27843366)
2016
15
Histological findings in the spleen affected by adult-onset Still's disease: a report of three cases. (26841850)
2016
16
Persistent Pruritic Lesions in Adult-onset Still's Disease. (27865305)
2016
17
Efficacy of tocilizumab therapy in Korean patients with adult-onset Still's disease: a multicentre retrospective study of 22 cases. (27462914)
2016
18
Successful treatment of refractory adult onset Still's disease with rituximab. (27981819)
2016
19
Adult onset Still's disease accompanied by acute respiratory distress syndrome: A case report. (27588099)
2016
20
Successful Tocilizumab Therapy for Macrophage Activation Syndrome Associated with Adult-Onset Still's Disease: A Case-Based Review. (27688774)
2016
21
Herpes Zoster Meningitis Complicating Combined Tocilizumab and Cyclosporine Therapy for Adult-Onset Still's Disease. (27092286)
2016
22
A case report of successful treatment of 90A^ knee flexion contracture in a patient with adult-onset Still's disease. (26860205)
2016
23
Adult onset still's disease- A rare presentation. (27728682)
2016
24
Adult-onset Still's disease: an Italian multicentre retrospective observational study of manifestations and treatments in 245 patients. (27207567)
2016
25
A Rare Ocular Manifestation of Adult Onset Still's Disease: Purtscher's-like Retinopathy. (27599266)
2016
26
Intravitreal dexamethasone implants for the treatment of refractory scleritis combined with uveitis in adult-onset Still's disease: a case report. (27825329)
2016
27
Macrophage activation syndrome triggered by disseminated tuberculosis with tuberculous gumma in a patient with adult-onset Still's disease and Good's syndrome. (27018416)
2016
28
Resolution of severe pulmonary arterial hypertension complicating adult-onset Still's disease. (27216503)
2016
29
Macrophage activation syndrome associated with tocilizumab treatment in adult-onset Still's disease. (27778518)
2016
30
Bartonella henselae infection presenting with a picture of adult-onset Still's disease. (27000538)
2016
31
Cytokine profile in adult-onset Still's disease: Comparison with systemic juvenile idiopathic arthritis. (27263804)
2016
32
Pulmonary arterial hypertension secondary to adult-onset Still's disease: Response to cyclosporine and sildenafil over 15 years of follow-up. (27408785)
2016
33
Adult Onset Still's Disease: A Review on Diagnostic Workup and Treatment Options. (27042373)
2016
34
Elevated high-mobility group B1 levels in active adult-onset Still's disease associated with systemic score and skin rash. (27225247)
2016
35
Metabolic Disturbances in Adult-Onset Still's Disease Evaluated Using Liquid Chromatography/Mass Spectrometry-Based Metabolomic Analysis. (28005947)
2016
36
Adult-onset Still's disease-like manifestation accompanied by the cancer recurrence after long-term resting state. (27846765)
2016
37
Pulmonary arterial hypertension in adult onset Still's disease: a case report of a severe complication. (27160441)
2016
38
Efficacy of Low-Dose Tocilizumab on Relapsing Adult-Onset Still's Disease. (27131353)
2016
39
Adult Onset Still's Disease Associated with Mycoplasma pneumoniae Infection and Hemophagocytic Lymphohistiocytosis. (27847518)
2016
40
Combination Immunosuppressive Therapy Including Rituximab for Epstein-Barr Virus-Associated Hemophagocytic Lymphohistiocytosis in Adult-Onset Still's Disease. (28018698)
2016
41
Elevated serum levels of free interleukin-18 in adult-onset Still's disease. (27616144)
2016
42
A retrospective study of patients with adult-onset Still's disease: is pericarditis a possible predictor for biological disease-modifying anti-rheumatic drugs need? (26758435)
2016
43
An atypical presentation of adult-onset Still's disease complicated by pulmonary hypertension and macrophage activation syndrome treated with immunosuppression: a case-based review of the literature. (27162622)
2016
44
Adult Onset Still's Disease With Different Antibodies: A Case Report and Review of Literature. (27888598)
2016
45
Neonatal Haemophagocytic Lymphohistiocytosis Associated with Maternal Adult-Onset Still's Disease. (27304999)
2016
46
Adult-onset Still's disease: Advances in the treatment. (27886796)
2016
47
Limited diagnostic value of procalcitonin in early diagnosis of adult onset Still's disease. (27826176)
2016
48
The role of 18F-fluorodeoxyglucose positron emission tomography in the assessment of disease activity of adult-onset Still's disease. (27926812)
2016
49
Macrophage Activation Syndrome Associated with Adult-Onset Still's Disease Successfully Treated with Anakinra. (27818826)
2016
50
Adult-onset Still's disease with myocarditis and hemophagocytic lymphohistiocytosis: Rare manifestation with fatal outcome. (26960645)
2016

Variations for Adult-Onset Still's Disease

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Expression for genes affiliated with Adult-Onset Still's Disease

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Search GEO for disease gene expression data for Adult-Onset Still's Disease.

Pathways for genes affiliated with Adult-Onset Still's Disease

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Pathways related to Adult-Onset Still's Disease according to GeneCards Suite gene sharing:

(show top 50)    (show all 61)
idSuper pathwaysScoreTop Affiliating Genes
19.8IL18, IL1R1
29.7IL6, TNF
39.7IL18, IL1B
49.6IL1B, IL6
59.4CRP, IL6, TNF
6
Show member pathways
9.3IL18, IL1B, IL6
79.2IL18, IL1B, IL1R1
8
Show member pathways
9.2IL18, IL1B, IL1R1
9
Show member pathways
9.2IL1B, IL1R1, IL6
109.2IL18, IL1B, TNF
11
Show member pathways
9.2IL1B, IL1R1, IL1RN
129.2IL1B, IL6, TNF
139.2IL1B, IL6, TNF
149.2IL1B, IL6, TNF
159.2IL1B, IL6, TNF
169.2IL1B, IL6, TNF
179.2IL1B, IL6, TNF
189.2IL6, MIF, TNF
199.1IL1B, IL1R1, TNF
20
Show member pathways
9.1IL1B, IL1R1, TNF
219.1IL1B, IL1R1, TNF
229.0IL18, IL1B, MEFV
23
Show member pathways
8.9IL18, IL1B, IL6, TNF
248.9IL18, IL1B, IL6, TNF
25
Show member pathways
8.9IL18, IL1B, IL6, TNF
268.9IL18, IL1B, IL6, TNF
278.9CSF1, IL6, TNF
28
Show member pathways
8.9IL18, IL1B, IL6, TNF
29
Show member pathways
8.9IL18, IL1B, IL6, TNF
30
Show member pathways
8.9IL18, IL1B, IL6, TNF
318.9IL18, IL1B, IL6, TNF
328.9IL18, IL1B, IL6, TNF
338.9IL18, IL1B, IL6, TNF
348.9IL18, IL1B, IL6, TNF
358.8IL18, IL1B, IL1R1, TNF
368.8CSF1, IL1B, IL6
378.8IL1B, IL1RN, IL6, TNF
38
Show member pathways
8.7IL1B, IL1R1, IL6, TNF
398.7IL1B, IL1R1, IL6, TNF
40
Show member pathways
8.7IL1B, IL1R1, IL6, TNF
418.7CSF1, IL1B, TNF
42
Show member pathways
8.6IL1B, IL6, MIF, TNF
43
Show member pathways
8.4IL18, IL1B, IL1R1, IL6, TNF
448.4CSF1, IL18, IL1B, TNF
458.3CSF1, IL1B, IL6, TNF
468.3CSF1, IL1B, IL6, TNF
478.3CSF1, IL1B, IL6, TNF
488.3CSF1, IL1B, IL1R1, TNF
498.2IL1B, IL1R1, IL6, MIF, TNF
50
Show member pathways
8.2IL1B, IL1R1, IL6, MIF, TNF

GO Terms for genes affiliated with Adult-Onset Still's Disease

About this section

Cellular components related to Adult-Onset Still's Disease according to GeneCards Suite gene sharing:

idNameGO IDScoreTop Affiliating Genes
1vesicleGO:00319829.1IL1B, IL1RN, MIF
2extracellular spaceGO:00056157.4CRP, CSF1, IL18, IL1B, IL1RN, IL6
3extracellular regionGO:00055767.1CRP, CSF1, IL18, IL1B, IL1R1, IL1RN

Biological processes related to Adult-Onset Still's Disease according to GeneCards Suite gene sharing:

(show all 42)
idNameGO IDScoreTop Affiliating Genes
1negative regulation of interleukin-1-mediated signaling pathwayGO:200066010.5IL1RN, IL6
2negative regulation of myoblast differentiationGO:004566210.4IL18, TNF
3epithelial cell proliferation involved in salivary gland morphogenesisGO:006066410.4IL6, TNF
4positive regulation of chemokine productionGO:003272210.4IL6, TNF
5positive regulation of granulocyte macrophage colony-stimulating factor productionGO:003272510.4IL18, IL1B
6positive regulation of T-helper 2 cell differentiationGO:004563010.4IL18, IL6
7negative regulation of lipid catabolic processGO:005099510.2IL1B, TNF
8positive regulation of calcidiol 1-monooxygenase activityGO:006055910.2IL1B, TNF
9positive regulation of chemokine biosynthetic processGO:004508010.2IL1B, TNF
10positive regulation of chemokine (C-X-C motif) ligand 2 productionGO:200034310.2MIF, TNF
11positive regulation of cytokine secretionGO:005071510.2MIF, TNF
12positive regulation of fever generationGO:003162210.2IL1B, TNF
13positive regulation of heterotypic cell-cell adhesionGO:003411610.2IL1B, TNF
14positive regulation of interleukin-8 productionGO:003275710.2IL1B, TNF
15positive regulation of membrane protein ectodomain proteolysisGO:005104410.2IL1B, TNF
16positive regulation of phagocytosisGO:005076610.2IL1B, TNF
17defense response to Gram-positive bacteriumGO:005083010.1CRP, IL6, TNF
18negative regulation of lipid storageGO:001088810.1CRP, IL6, TNF
19positive regulation of macrophage derived foam cell differentiationGO:001074410.0CSF1, IL18
20positive regulation of protein kinase B signalingGO:005189710.0IL18, IL6, TNF
21regulation of establishment of endothelial barrierGO:190314010.0IL1B, TNF
22regulation of I-kappaB kinase/NF-kappaB signalingGO:004312210.0IL1B, TNF
23cellular response to organic cyclic compoundGO:007140710.0IL18, IL1B, TNF
24cytokine-mediated signaling pathwayGO:001922110.0IL1B, IL1R1, IL6
25lipopolysaccharide-mediated signaling pathwayGO:00316639.9IL18, IL1B, TNF
26osteoclast differentiationGO:00303169.9CSF1, TNF
27positive regulation of smooth muscle cell proliferationGO:00486619.9IL18, IL6, TNF
28positive regulation of interferon-gamma productionGO:00327299.9IL18, IL1B, TNF
29positive regulation of NF-kappaB import into nucleusGO:00423469.9IL18, IL1B, TNF
30positive regulation of ERK1 and ERK2 cascadeGO:00703749.9IL6, MIF, TNF
31positive regulation of osteoclast differentiationGO:00456729.9CSF1, TNF
32positive regulation of interleukin-6 productionGO:00327559.8IL1B, IL6, TNF
33positive regulation of NF-kappaB transcription factor activityGO:00510929.8IL1B, IL6, TNF
34positive regulation of nitric oxide biosynthetic processGO:00454299.8IL1B, IL6, TNF
35positive regulation of peptidyl-serine phosphorylationGO:00331389.8IL6, MIF, TNF
36positive regulation of sequence-specific DNA binding transcription factor activityGO:00510919.7IL1B, IL6, TNF
37positive regulation of protein phosphorylationGO:00019349.6IL1B, MIF, TNF
38sequestering of triglycerideGO:00307309.5IL1B, TNF
39response to glucocorticoidGO:00513849.4IL1RN, IL6, TNF
40immune responseGO:00069558.8IL18, IL1B, IL1R1, IL1RN, IL6, TNF
41positive regulation of gene expressionGO:00106288.7CRP, CSF1, IL1B, IL6, TNF
42inflammatory responseGO:00069546.9CRP, CSF1, IL18, IL1B, IL1RN, IL6

Molecular functions related to Adult-Onset Still's Disease according to GeneCards Suite gene sharing:

idNameGO IDScoreTop Affiliating Genes
1interleukin-1 receptor bindingGO:00051499.6IL1B, IL1RN
2cytokine activityGO:00051257.5CSF1, IL18, IL1B, IL1RN, IL6, MIF

Sources for Adult-Onset Still's Disease

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2CDC
6CNVD
10DGIdb
15ExPASy
16FDA
17FMA
27GTR
28HGMD
29HMDB
30ICD10
31ICD10 via Orphanet
32ICD9CM
33IUPHAR
34KEGG
37MedGen
39MeSH
40MESH via Orphanet
41MGI
44NCI
45NCIt
46NDF-RT
49NINDS
50Novoseek
52OMIM
53OMIM via Orphanet
57PubMed
58QIAGEN
63SNOMED-CT via Orphanet
67Tumor Gene Family of Databases
68UMLS
69UMLS via Orphanet