MCID: ADL030
MIFTS: 60

Adult-Onset Still's Disease

Categories: Rare diseases, Nephrological diseases, Bone diseases

Aliases & Classifications for Adult-Onset Still's Disease

MalaCards integrated aliases for Adult-Onset Still's Disease:

Name: Adult-Onset Still's Disease 12 50 14
Adult-Onset Still Disease 12 56 69
Still's Disease, Adult-Onset 42
Adult Onset Still's Disease 12
Still's Disease Adult Onset 50
Stills Disease Adult-Onset 52
Wissler-Fanconi Syndrome 56
Adult Still's Disease 50
Wissler's Syndrome 69
Aosd 56

Characteristics:

Orphanet epidemiological data:

56
adult-onset still disease
Inheritance: Not applicable; Prevalence: 1-9/1000000 (France),1-9/1000000 (Japan),1-9/1000000 (Norway),1-9/100000 (Norway),1-9/100000 (Europe),1-9/1000000 (Turkey),1-9/100000 (Turkey); Age of onset: Adult; Age of death: normal life expectancy;

Classifications:



Summaries for Adult-Onset Still's Disease

NIH Rare Diseases : 50 adult-onset still's disease is an inflammatory condition characterized by high fevers, rash, sore throat, and joint pain. as it progresses, adult-onset still's disease may lead to chronic arthritis and other complications. still's disease was named after an english doctor named george still, who described the condition in children in 1896. still's disease which occurs in children (those under the age of 16) is now known as systemic onset juvenile rheumatoid arthritis (jra). in 1971, the term "adult still's disease" was used to describe adults who had a condition similar to systemic onset jra. the cause of adult-onset still's disease is unknown. no risk factors for the disease have been identified. there's no cure for adult-onset still's disease; however, treatment may offer symptom relief and help prevent complications.  last updated: 5/28/2014

MalaCards based summary : Adult-Onset Still's Disease, also known as adult-onset still disease, is related to lymphoma and wissler's syndrome, and has symptoms including hepatomegaly, splenomegaly and fatigue. An important gene associated with Adult-Onset Still's Disease is IL18 (Interleukin 18), and among its related pathways/superpathways are Innate Immune System and PEDF Induced Signaling. The drugs Antirheumatic Agents and Interleukin 1 Receptor Antagonist Protein have been mentioned in the context of this disorder. Affiliated tissues include liver, bone and skin, and related phenotypes are Decreased shRNA abundance (Z-score < -2) and cardiovascular system

Disease Ontology : 12 An arthritis that is a rare from of inflammatory arthritis characterized by fevers, rash, and joint pain.

Related Diseases for Adult-Onset Still's Disease

Diseases related to Adult-Onset Still's Disease via text searches within MalaCards or GeneCards Suite gene sharing:

(show top 50) (show all 276)
id Related Disease Score Top Affiliating Genes
1 lymphoma 29.3 IL1B IL6 MEFV TNF
2 wissler's syndrome 11.1
3 collagenopathy type 2 alpha 1 10.7 CRP IL6
4 brachydactyly-distal symphalangism syndrome 10.7 CRP IL6
5 erythema elevatum diutinum 10.7 CRP IL6
6 cataract congenital autosomal dominant 10.7 CRP IL6
7 chronic diarrhea due to guanylate cyclase 2c overactivity 10.7 CRP IL6
8 smarca4-deficient sarcoma of thorax 10.6 IL6 TNF
9 aortic arch interruption 10.6 IL6 TNF
10 malignant gastric granular cell tumor 10.6 CRP IL6
11 cutaneous leishmaniasis 10.6 IL6 TNF
12 euthyroid sick syndrome 10.6 CRP TNF
13 nodular nonsuppurative panniculitis 10.6 CRP IL6
14 cauda equina syndrome 10.6 IL18 TNF
15 spirillary rat-bite fever 10.6 IL6 TNF
16 toxoplasmosis 10.6 IL6 TNF
17 hemangioma of spleen 10.6 CRP IL6
18 dyslexia 5 10.6 IL6 TNF
19 anencephaly and spina bifida x-linked 10.6 IL6 TNF
20 lung occult large cell carcinoma 10.6 CRP IL6
21 antigen-peptide-transporter 2 deficiency 10.6 IL6 TNF
22 papilledema 10.6 IL6 TNF
23 ethmoid sinus adenocarcinoma 10.6 IL6 TNF
24 potato nose 10.6 IL6 TNF
25 ariboflavinosis 10.5 CRP IL6
26 partial circumpapillary choroid dystrophy 10.5 CRP MEFV
27 lymphocytic colitis 10.5 IL6 TNF
28 amyloidosis nodular localized cutaneous 10.5 CRP MEFV
29 pasteurellosis 10.5 IL6 TNF
30 craniometaphyseal dysplasia 10.5 MEFV TNF
31 porokeratosis 3, multiple types 10.5 CRP IL1RN
32 cerebral hemorrhage 10.5 CRP IL1RN
33 multiple congenital anomalies mental retardation, growth failure and cleft lip palate 10.5 CRP IL6
34 vogt-koyanagi-harada disease 10.5 IL6 TNF
35 petrous apex meningioma 10.5 CRP TNF
36 allergic bronchopulmonary aspergillosis 10.5 CRP IL18 IL6
37 deafness, autosomal recessive 67 10.5 IL18 TNF
38 polyarteritis nodosa 10.5 CRP TNF
39 tetanus 10.4 MEFV TNF
40 queensland tick typhus 10.4 CRP IL6
41 multiple sclerosis 5 10.4 MEFV TNF
42 bladder calculus 10.4 IL1RN TNF
43 cryoglobulinemia 10.4 CRP IL18 IL6
44 oculomotor nerve paralysis 10.4 IL1B IL6
45 common peroneal nerve lesion 10.4 IL1B IL6
46 tricho onychic dysplasia 10.4 IL6 TNF
47 pulmonary plasma cell granuloma 10.4 CRP IL1B
48 phlyctenulosis 10.4 IL6 TNF
49 reardon wilson cavanagh syndrome 10.4 IL18 IL6 TNF
50 infancy electroclinical syndrome 10.4 IL1B IL6

Graphical network of the top 20 diseases related to Adult-Onset Still's Disease:



Diseases related to Adult-Onset Still's Disease

Symptoms & Phenotypes for Adult-Onset Still's Disease

Human phenotypes related to Adult-Onset Still's Disease:

56 32 (show all 30)
id Description HPO Frequency Orphanet Frequency HPO Source Accession
1 hepatomegaly 56 32 hallmark (90%) Very frequent (99-80%) HP:0002240
2 splenomegaly 56 32 hallmark (90%) Very frequent (99-80%) HP:0001744
3 fatigue 56 32 hallmark (90%) Very frequent (99-80%) HP:0012378
4 pericarditis 56 32 frequent (33%) Frequent (79-30%) HP:0001701
5 pleuritis 56 32 frequent (33%) Frequent (79-30%) HP:0002102
6 arthritis 56 32 hallmark (90%) Very frequent (99-80%) HP:0001369
7 myalgia 56 32 frequent (33%) Frequent (79-30%) HP:0003326
8 fever 56 32 hallmark (90%) Very frequent (99-80%) HP:0001945
9 abdominal pain 56 32 frequent (33%) Frequent (79-30%) HP:0002027
10 pruritus 56 32 hallmark (90%) Very frequent (99-80%) HP:0000989
11 skin rash 56 32 hallmark (90%) Very frequent (99-80%) HP:0000988
12 arthralgia 56 32 hallmark (90%) Very frequent (99-80%) HP:0002829
13 erythema 56 32 hallmark (90%) Very frequent (99-80%) HP:0010783
14 myocarditis 56 32 occasional (7.5%) Occasional (29-5%) HP:0012819
15 joint swelling 56 32 hallmark (90%) Very frequent (99-80%) HP:0001386
16 leukocytosis 56 32 hallmark (90%) Very frequent (99-80%) HP:0001974
17 generalized lymphadenopathy 56 32 frequent (33%) Frequent (79-30%) HP:0008940
18 meningitis 56 32 occasional (7.5%) Occasional (29-5%) HP:0001287
19 elevated hepatic transaminases 56 32 occasional (7.5%) Occasional (29-5%) HP:0002910
20 elevated erythrocyte sedimentation rate 56 32 hallmark (90%) Very frequent (99-80%) HP:0003565
21 hepatitis 56 32 occasional (7.5%) Occasional (29-5%) HP:0012115
22 bone marrow hypocellularity 56 32 occasional (7.5%) Occasional (29-5%) HP:0005528
23 abnormality of lipid metabolism 56 32 occasional (7.5%) Occasional (29-5%) HP:0003119
24 recurrent pharyngitis 56 32 occasional (7.5%) Occasional (29-5%) HP:0100776
25 elevated c-reactive protein level 56 32 hallmark (90%) Very frequent (99-80%) HP:0011227
26 cartilage destruction 56 32 occasional (7.5%) Occasional (29-5%) HP:0100773
27 restrictive lung disease 56 Very frequent (99-80%)
28 neutrophilia 32 hallmark (90%) HP:0011897
29 restrictive ventilatory defect 32 hallmark (90%) HP:0002091
30 neutrophillia 56 Very frequent (99-80%)

UMLS symptoms related to Adult-Onset Still's Disease:


exanthema

GenomeRNAi Phenotypes related to Adult-Onset Still's Disease according to GeneCards Suite gene sharing:

26
id Description GenomeRNAi Source Accession Score Top Affiliating Genes
1 Decreased shRNA abundance (Z-score < -2) GR00366-A-116 9.58 CSF1 IL1B IL1R1 MIF
2 Decreased shRNA abundance (Z-score < -2) GR00366-A-139 9.58 IL1B IL1R1
3 Decreased shRNA abundance (Z-score < -2) GR00366-A-14 9.58 IL1B
4 Decreased shRNA abundance (Z-score < -2) GR00366-A-142 9.58 CSF1
5 Decreased shRNA abundance (Z-score < -2) GR00366-A-17 9.58 MIF
6 Decreased shRNA abundance (Z-score < -2) GR00366-A-180 9.58 CSF1
7 Decreased shRNA abundance (Z-score < -2) GR00366-A-181 9.58 IL1B
8 Decreased shRNA abundance (Z-score < -2) GR00366-A-33 9.58 IL1R1
9 Decreased shRNA abundance (Z-score < -2) GR00366-A-72 9.58 MIF
10 Decreased shRNA abundance (Z-score < -2) GR00366-A-75 9.58 MIF
11 Decreased shRNA abundance (Z-score < -2) GR00366-A-84 9.58 CSF1
12 Decreased shRNA abundance (Z-score < -2) GR00366-A-87 9.58 MIF
13 Decreased shRNA abundance (Z-score < -2) GR00366-A-91 9.58 CSF1
14 Decreased shRNA abundance (Z-score < -2) GR00366-A-98 9.58 MIF

MGI Mouse Phenotypes related to Adult-Onset Still's Disease:

44
id Description MGI Source Accession Score Top Affiliating Genes
1 cardiovascular system MP:0005385 10.03 TNF IL1B IL1R1 CRP IL1RN CSF1
2 hematopoietic system MP:0005397 10.02 TNF IL1B MEFV MIF IL1R1 IL1RN
3 homeostasis/metabolism MP:0005376 10.02 TNF IL1B MEFV MIF IL1R1 CRP
4 cellular MP:0005384 10.01 TNF MEFV MIF IL1R1 IL1RN CSF1
5 immune system MP:0005387 9.96 TNF MEFV IL1R1 MIF CRP IL1RN
6 integument MP:0010771 9.76 TNF IL1B MEFV IL1R1 IL1RN CSF1
7 neoplasm MP:0002006 9.35 MIF TNF IL1B IL1R1 IL6
8 skeleton MP:0005390 9.17 TNF IL1B MEFV IL1R1 IL1RN CSF1

Drugs & Therapeutics for Adult-Onset Still's Disease

Drugs for Adult-Onset Still's Disease (from DrugBank, HMDB, Dgidb, PharmGKB, IUPHAR, NovoSeek, BitterDB):

(show all 26)
id Name Status Phase Clinical Trials Cas Number PubChem Id
1 Antirheumatic Agents Phase 3,Phase 2
2 Interleukin 1 Receptor Antagonist Protein Phase 3,Phase 2
3
Azathioprine Approved Phase 2 446-86-6 2265
4
Leflunomide Approved, Investigational Phase 2 75706-12-6 3899
5
Methotrexate Approved Phase 2 1959-05-2, 59-05-2 126941
6
Methylprednisolone Approved, Vet_approved Phase 2 83-43-2 6741
7
Prednisolone Approved, Vet_approved Phase 2 50-24-8 5755
8
Folic Acid Approved, Nutraceutical, Vet_approved Phase 2 59-30-3 6037
9
leucovorin Approved, Nutraceutical Phase 2 58-05-9 143 6006
10 Antibodies Phase 2
11 Antibodies, Monoclonal Phase 2
12 Immunoglobulins Phase 2
13 Antimetabolites Phase 2
14 Antimetabolites, Antineoplastic Phase 2
15 Dermatologic Agents Phase 2
16 Folic Acid Antagonists Phase 2
17 Immunosuppressive Agents Phase 2
18 Methylprednisolone acetate Phase 2
19 Methylprednisolone Hemisuccinate Phase 2
20 Nucleic Acid Synthesis Inhibitors Phase 2
21 Prednisolone acetate Phase 2
22 Prednisolone hemisuccinate Phase 2
23 Prednisolone phosphate Phase 2
24 Vitamin B Complex Phase 2
25 Folate Nutraceutical Phase 2
26 Vitamin B9 Nutraceutical Phase 2

Interventional clinical trials:


id Name Status NCT ID Phase Drugs
1 A Study to Evaluate Efficacy and Safety of Anakinra in the Treatment of Still's Disease (SJIA and AOSD) Recruiting NCT03265132 Phase 3 Placebo
2 Efficacy and Safety of Tocilizumab in Adult's Still Disease Unknown status NCT01002781 Phase 2 Tocilizumab
3 Treatment of Refractory Adult-onset Still's Disease With Anakinra: a Randomized Study Completed NCT01033656 Phase 2 anakinra;comparators
4 Therapeutic Use of Tadekinig Alfa in Adult-onset Still's Disease Completed NCT02398435 Phase 2
5 Interleukin-1 Trap to Treat Autoinflammatory Diseases Completed NCT00094900 Phase 2 IL-1 Trap
6 Canakinumab for Treatment of Adult Onset Still's Disease Recruiting NCT02204293 Phase 2 Canakinumab;Placebo
7 Tocilizumab in Patients With Schnitzler's Syndrome Recruiting NCT03046381 Phase 2 Tocilizumab
8 Glycosylated Ferritin in Macrophagic Activation Syndromes Recruiting NCT02143986
9 Admission of Adult-onset Still Disease Patients in the ICU Not yet recruiting NCT03276650

Search NIH Clinical Center for Adult-Onset Still's Disease

Cochrane evidence based reviews: still's disease, adult-onset

Genetic Tests for Adult-Onset Still's Disease

Anatomical Context for Adult-Onset Still's Disease

MalaCards organs/tissues related to Adult-Onset Still's Disease:

39
Liver, Bone, Skin, Lung, T Cells, Lymph Node, Bone Marrow

Publications for Adult-Onset Still's Disease

Articles related to Adult-Onset Still's Disease:

(show top 50) (show all 624)
id Title Authors Year
1
Effects of HLA-DRB1 alleles on susceptibility and clinical manifestations in Japanese patients with adult onset Still's disease. ( 28899403 )
2017
2
Adult-onset Still's disease-like condition due to alcoholic hepatitis and vitamin B deficiency. ( 28691376 )
2017
3
Treatment of adult-onset still's disease: up to date. ( 28540751 )
2017
4
How I treat patients with adult onset Still's disease in clinical practice. ( 28778712 )
2017
5
Response to Interleukin-1 Inhibitors in 140 Italian Patients with Adult-Onset Still's Disease: A Multicentre Retrospective Observational Study. ( 28659802 )
2017
6
Delay in the Diagnosis of Adult-Onset Still's Disease. ( 28690954 )
2017
7
Rumpel-Leede phenomenon in a patient with adult-onset Still's disease. ( 28130282 )
2017
8
Imaging characteristics of adult onset Still's disease demonstrated with 18F-FDG PET/CT. ( 28765926 )
2017
9
Phosphorylated signal transducer and activator of transcription 3 in the epidermis in adult-onset Still's disease. ( 28470759 )
2017
10
Unusual manifestations and unusual mimics of adult onset Still's disease. ( 28397955 )
2017
11
Validation of the Fautrel classification criteria for adult-onset Still's disease. ( 28760536 )
2017
12
The neutrophil-to-lymphocyte ratio could be a good diagnostic marker and predictor of relapse in patients with adult-onset Still's disease: A STROBE-compliant retrospective observational analysis. ( 28723775 )
2017
13
Upregulation of circulating microRNA-134 in adult-onset Still's disease and its use as potential biomarker. ( 28646209 )
2017
14
Red blood cell distribution width is useful in discriminating adult onset Still's disease and sepsis within 24 hours after hospitalization. ( 28838228 )
2017
15
Adult onset Still's disease-The evidence that anti-interleukin-1 treatment is effective and well-tolerated (a comprehensive literature review). ( 28757235 )
2017
16
Highly Expression of CD11b and CD32 on Peripheral Blood Mononuclear Cells from Patients with Adult-Onset Still's Disease. ( 28106835 )
2017
17
Adult-onset Still's disease with atypical cutaneous manifestations. ( 28296747 )
2017
18
Elevated circulating levels of the interferon-I^-induced chemokines are associated with disease activity and cutaneous manifestations in adult-onset Still's disease. ( 28436448 )
2017
19
New Markers for Adult-Onset Still's Disease. ( 28529117 )
2017
20
Adult-Onset Still's Disease: Still a Serious Health Problem (a Case Report and Literature Review). ( 28154368 )
2017
21
Biologic drugs in adult onset Still's disease: a systematic review and meta-analysis of observational studies. ( 28870100 )
2017
22
Serum Levels of Interleukin 33 and Soluble ST2 Are Associated with the Extent of Disease Activity and Cutaneous Manifestations in Patients with Active Adult-onset Still's Disease. ( 28365573 )
2017
23
Atypical form of adult-onset Still's disease with distal interphalangeal joints involvement. ( 28758587 )
2017
24
Adult-onset Still's disease presenting with shawl sign-like eruption. ( 28925003 )
2017
25
Hemophagocytic lymphohistiocytosis with high serum levels of IL-18 and predominant lymphocyte activation in a neonate born to a mother with adult-onset Still's disease. ( 28450255 )
2017
26
Inadvertent Skipping of Steroids in Septic Shock Leads to a Diagnosis of Adult Onset Still's Disease. ( 28191382 )
2017
27
Pneumonitis in Adult Onset Still's Disease: Uncommon or Under Diagnosed? ( 28926333 )
2017
28
Macrophage activation syndrome associated with tocilizumab treatment in adult-onset Still's disease. ( 27778518 )
2016
29
Pulmonary arterial hypertension secondary to adult-onset Still's disease: Response to cyclosporine and sildenafil over 15 years of follow-up. ( 27408785 )
2016
30
Atypical Cutaneous Manifestations in Adult Onset Still's Disease. ( 26981304 )
2016
31
Efficacy of tocilizumab therapy in Korean patients with adult-onset Still's disease: a multicentre retrospective study of 22 cases. ( 27462914 )
2016
32
Limited diagnostic value of procalcitonin in early diagnosis of adult onset Still's disease. ( 27826176 )
2016
33
Macrophage Activation Syndrome Associated with Adult-Onset Still's Disease Successfully Treated with Anakinra. ( 27818826 )
2016
34
Adult Onset Still's Disease: A Review on Diagnostic Workup and Treatment Options. ( 27042373 )
2016
35
Adult-onset Still's disease: Advances in the treatment. ( 27886796 )
2016
36
Histological findings in the spleen affected by adult-onset Still's disease: a report of three cases. ( 26841850 )
2016
37
Adult-onset Still's disease-like manifestation accompanied by the cancer recurrence after long-term resting state. ( 27846765 )
2016
38
H-ferritin and CD68(+) /H-ferritin(+) monocytes/macrophages are increased in the skin of adult-onset Still's disease patients and correlate with the multi-visceral involvement of the disease. ( 27317930 )
2016
39
Elevated high-mobility group B1 levels in active adult-onset Still's disease associated with systemic score and skin rash. ( 27225247 )
2016
40
TLR4 Endogenous Ligand S100A8/A9 Levels in Adult-Onset Still's Disease and Their Association with Disease Activity and Clinical Manifestations. ( 27537874 )
2016
41
Pulmonary arterial hypertension in adult onset Still's disease: a case report of a severe complication. ( 27160441 )
2016
42
The role of 18F-fluorodeoxyglucose positron emission tomography in the assessment of disease activity of adult-onset Still's disease. ( 27926812 )
2016
43
Adult onset still's disease- A rare presentation. ( 27728682 )
2016
44
Neonatal Haemophagocytic Lymphohistiocytosis Associated with Maternal Adult-Onset Still's Disease. ( 27304999 )
2016
45
Response rate of initial conventional treatments, disease course, and related factors of patients with adult-onset Still's disease: Data from a large multicenter cohort. ( 26970681 )
2016
46
An atypical presentation of adult-onset Still's disease complicated by pulmonary hypertension and macrophage activation syndrome treated with immunosuppression: a case-based review of the literature. ( 27162622 )
2016
47
Macrophage activation syndrome triggered by disseminated tuberculosis with tuberculous gumma in a patient with adult-onset Still's disease and Good's syndrome. ( 27018416 )
2016
48
Adult-onset Still's disease: evaluation of prognostic tools and validation of the systemic score by analysis of 100 cases from three centers. ( 27903264 )
2016
49
Persistent Pruritic Lesions in Adult-onset Still's Disease. ( 27865305 )
2016
50
Efficacy of Low-Dose Tocilizumab on Relapsing Adult-Onset Still's Disease. ( 27131353 )
2016

Variations for Adult-Onset Still's Disease

Expression for Adult-Onset Still's Disease

Search GEO for disease gene expression data for Adult-Onset Still's Disease.

Pathways for Adult-Onset Still's Disease

Pathways related to Adult-Onset Still's Disease according to GeneCards Suite gene sharing:

(show top 50) (show all 60)
id Super pathways Score Top Affiliating Genes
1
Show member pathways
13.84 CRP CSF1 IL18 IL1B IL1R1 IL1RN
2
Show member pathways
13.56 CSF1 IL18 IL1B IL1R1 IL6 MIF
3
Show member pathways
13.32 CSF1 IL18 IL1B IL1R1 IL6 TNF
4
Show member pathways
13.28 CSF1 IL18 IL1B IL1R1 IL1RN IL6
5
Show member pathways
13.22 CSF1 IL18 IL1B IL1R1 IL6 TNF
6
Show member pathways
12.81 IL18 IL1B IL1R1 IL1RN IL6 MEFV
7
Show member pathways
12.72 IL18 IL1B IL6 TNF
8
Show member pathways
12.66 IL18 IL1B IL6 TNF
9
Show member pathways
12.63 IL1B IL1R1 IL6 TNF
10
Show member pathways
12.57 IL18 IL1B IL1R1 IL6 TNF
11
Show member pathways
12.54 IL18 IL1B IL6 TNF
12 12.22 IL18 IL1B IL6 TNF
13
Show member pathways
12.21 IL1B IL1R1 IL1RN
14
Show member pathways
12.19 IL1B IL1R1 IL6 MIF TNF
15
Show member pathways
12.18 IL1B IL1R1 IL6 TNF
16 12.17 IL1B IL1RN IL6 TNF
17
Show member pathways
12.15 IL18 IL1B IL6 TNF
18 12.05 CSF1 IL1B IL1R1 TNF
19 12.04 IL1B IL1R1 TNF
20 12.01 IL6 MIF TNF
21 11.98 IL18 IL1B IL6 TNF
22 11.96 CSF1 IL6 TNF
23
Show member pathways
11.94 IL18 IL1B IL1R1
24 11.94 CSF1 IL1B IL6 TNF
25
Show member pathways
11.93 IL18 IL1B IL6 TNF
26 11.88 IL1B IL6 TNF
27
Show member pathways
11.88 IL1B IL1R1 IL6
28 11.87 IL1B IL1R1 IL6 TNF
29 11.85 IL1B IL1R1 TNF
30 11.85 IL1B IL1R1 IL6 MIF TNF
31 11.8 IL18 IL1B IL6
32 11.77 IL18 IL1B IL1R1 TNF
33 11.75 IL1B IL6 TNF
34 11.74 CSF1 IL1B IL6 TNF
35 11.65 IL1B IL6 TNF
36
Show member pathways
11.64 IL1B IL6 MIF TNF
37 11.55 IL18 IL1B IL6 TNF
38 11.54 CSF1 IL1B IL1R1 IL6 TNF
39 11.53 CSF1 IL1B IL6
40 11.5 IL1B IL6 TNF
41
Show member pathways
11.48 IL1B IL1R1 TNF
42 11.47 IL18 IL1B IL6 TNF
43 11.45 IL18 IL1B MEFV
44 11.44 CSF1 IL18 IL1B TNF
45 11.37 IL1B IL6 TNF
46 11.31 IL1B IL6 TNF
47 11.31 CSF1 IL18 IL1B IL6 TNF
48 11.25 IL18 IL1B IL6 TNF
49 11.2 IL18 IL1B IL1R1
50 11.15 CSF1 IL18 IL1B IL6 TNF

GO Terms for Adult-Onset Still's Disease

Cellular components related to Adult-Onset Still's Disease according to GeneCards Suite gene sharing:

id Name GO ID Score Top Affiliating Genes
1 extracellular space GO:0005615 9.56 CRP CSF1 IL18 IL1B IL1RN IL6
2 vesicle GO:0031982 9.33 IL1B IL1RN MIF
3 extracellular region GO:0005576 9.28 CRP CSF1 IL18 IL1B IL1R1 IL1RN

Biological processes related to Adult-Onset Still's Disease according to GeneCards Suite gene sharing:

(show all 43)
id Name GO ID Score Top Affiliating Genes
1 positive regulation of ERK1 and ERK2 cascade GO:0070374 9.86 IL6 MIF TNF
2 positive regulation of protein phosphorylation GO:0001934 9.85 IL1B MIF TNF
3 cytokine-mediated signaling pathway GO:0019221 9.84 IL1B IL1R1 IL6
4 positive regulation of NF-kappaB transcription factor activity GO:0051092 9.84 IL1B IL6 TNF
5 positive regulation of sequence-specific DNA binding transcription factor activity GO:0051091 9.81 IL1B IL6 TNF
6 defense response to Gram-positive bacterium GO:0050830 9.79 CRP IL6 TNF
7 positive regulation of protein kinase B signaling GO:0051897 9.79 IL18 IL6 TNF
8 positive regulation of peptidyl-serine phosphorylation GO:0033138 9.77 IL6 MIF TNF
9 cellular response to organic cyclic compound GO:0071407 9.76 IL18 IL1B TNF
10 response to glucocorticoid GO:0051384 9.75 IL1RN IL6 TNF
11 immune response GO:0006955 9.73 IL18 IL1B IL1R1 IL1RN IL6 TNF
12 positive regulation of smooth muscle cell proliferation GO:0048661 9.71 IL18 IL6 TNF
13 positive regulation of phagocytosis GO:0050766 9.69 IL1B TNF
14 positive regulation of cytokine secretion GO:0050715 9.69 MIF TNF
15 positive regulation of interleukin-8 production GO:0032757 9.68 IL1B TNF
16 osteoclast differentiation GO:0030316 9.68 CSF1 TNF
17 negative regulation of myoblast differentiation GO:0045662 9.68 IL18 TNF
18 positive regulation of osteoclast differentiation GO:0045672 9.67 CSF1 TNF
19 negative regulation of lipid catabolic process GO:0050995 9.66 IL1B TNF
20 positive regulation of chemokine production GO:0032722 9.65 IL6 TNF
21 positive regulation of macrophage derived foam cell differentiation GO:0010744 9.65 CSF1 IL18
22 positive regulation of membrane protein ectodomain proteolysis GO:0051044 9.65 IL1B TNF
23 positive regulation of interleukin-6 production GO:0032755 9.65 IL1B IL6 TNF
24 regulation of I-kappaB kinase/NF-kappaB signaling GO:0043122 9.64 IL1B TNF
25 positive regulation of heterotypic cell-cell adhesion GO:0034116 9.63 IL1B TNF
26 positive regulation of granulocyte macrophage colony-stimulating factor production GO:0032725 9.63 IL18 IL1B
27 positive regulation of nitric oxide biosynthetic process GO:0045429 9.63 IL1B IL6 TNF
28 positive regulation of chemokine biosynthetic process GO:0045080 9.62 IL1B TNF
29 positive regulation of T-helper 2 cell differentiation GO:0045630 9.61 IL18 IL6
30 positive regulation of interferon-gamma production GO:0032729 9.61 IL18 IL1B TNF
31 regulation of establishment of endothelial barrier GO:1903140 9.59 IL1B TNF
32 epithelial cell proliferation involved in salivary gland morphogenesis GO:0060664 9.57 IL6 TNF
33 positive regulation of fever generation GO:0031622 9.55 IL1B TNF
34 lipopolysaccharide-mediated signaling pathway GO:0031663 9.54 IL18 IL1B TNF
35 sequestering of triglyceride GO:0030730 9.52 IL1B TNF
36 negative regulation of interleukin-1-mediated signaling pathway GO:2000660 9.51 IL1RN IL6
37 positive regulation of NF-kappaB import into nucleus GO:0042346 9.5 IL18 IL1B TNF
38 positive regulation of chemokine (C-X-C motif) ligand 2 production GO:2000343 9.49 MIF TNF
39 positive regulation of calcidiol 1-monooxygenase activity GO:0060559 9.4 IL1B TNF
40 positive regulation of gene expression GO:0010628 9.35 CRP CSF1 IL1B IL6 TNF
41 negative regulation of lipid storage GO:0010888 9.33 CRP IL6 TNF
42 inflammatory response GO:0006954 9.28 CRP CSF1 IL18 IL1B IL1RN IL6
43 fever generation GO:0001660 9.26 IL1B

Molecular functions related to Adult-Onset Still's Disease according to GeneCards Suite gene sharing:

id Name GO ID Score Top Affiliating Genes
1 cytokine activity GO:0005125 9.17 CSF1 IL18 IL1B IL1RN IL6 MIF
2 interleukin-1 receptor binding GO:0005149 9.16 IL1B IL1RN
3 protease binding GO:0002020 8.96 IL1R1 TNF

Sources for Adult-Onset Still's Disease

3 CDC
7 CNVD
9 Cosmic
10 dbSNP
11 DGIdb
16 ExPASy
18 FMA
28 GO
29 GTR
30 HGMD
31 HMDB
32 HPO
33 ICD10
34 ICD10 via Orphanet
35 ICD9CM
36 IUPHAR
37 KEGG
38 LifeMap
40 MedGen
42 MeSH
43 MESH via Orphanet
44 MGI
46 NCI
47 NCIt
48 NDF-RT
51 NINDS
52 Novoseek
54 OMIM
55 OMIM via Orphanet
59 PubMed
60 QIAGEN
65 SNOMED-CT via HPO
66 SNOMED-CT via Orphanet
67 TGDB
68 Tocris
69 UMLS
70 UMLS via Orphanet
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