MCID: ADL010
MIFTS: 53

Adult Respiratory Distress Syndrome malady

Respiratory diseases, Cardiovascular diseases, Rare diseases categories

Summaries for Adult Respiratory Distress Syndrome

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Disease Ontology:9 A respiratory failure that results from diffuse injury to the endothelium of the lung (as in sepsis, chest trauma, massive blood transfusion, aspiration of the gastric contents, or pneumonia) and is characterized by pulmonary edema with an abnormally high amount of protein in the edematous fluid and by difficult rapid breathing and hypoxemia.

MalaCards based summary: Adult Respiratory Distress Syndrome, also known as non-cardiogenic pulmonary edema, is related to acute respiratory distress syndrome and capillary leak syndrome. An important gene associated with Adult Respiratory Distress Syndrome is C4A (complement component 4A (Rodgers blood group)), and among its related pathways are Pertussis and Selected targets of C EBPbeta. The drugs acetylcysteine and methylprednisolone and the compounds sivelestat sodium hydrate and sivelestat have been mentioned in the context of this disorder. Affiliated tissues include lung, neutrophil and endothelial, and related mouse phenotype immune system.

Aliases & Classifications for Adult Respiratory Distress Syndrome

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Adult Respiratory Distress Syndrome, Aliases & Descriptions:

Name: Adult Respiratory Distress Syndrome 30 9 11
Non-Cardiogenic Pulmonary Edema 9 60
Respiratory Distress Syndrome, Adult 60
 
Shock Lung 9
Adult Rds 9
Ards 9


Classifications:

Malacards categories (disease lists): (See all malacards categories)
Global: Rare diseases
Anatomical: Respiratory diseases, Cardiovascular diseases


External Ids:

Disease Ontology9 DOID:11394
NCIt38 C3353
MeSH33 D012128
ICD1025 J80

Related Diseases for Adult Respiratory Distress Syndrome

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Diseases in the Adult Respiratory Distress Syndrome family:

Acute Respiratory Distress Syndrome Adult Acute Respiratory Distress Syndrome

Diseases related to Adult Respiratory Distress Syndrome via text searches within MalaCards or GeneCards Suite gene sharing:

(show top 50)    (show all 164)
idRelated DiseaseScoreTop Affiliating Genes
1acute respiratory distress syndrome30.9IL8, ELANE
2capillary leak syndrome30.9ELANE
3pulmonary hypertension30.6ELANE, SFTPC
4pneumonia30.6SFTPC, SOD3, ELANE, IL8
5acute pancreatitis30.3IL8, ELANE
6pulmonary fibrosis29.6IL8, ELANE, SOD3, SFTPC
7rheumatoid arthritis29.3SOD3, ELANE, ANGPT2, IL8
8miliary tuberculosis10.8
9tuberculosis10.8
10burns10.5
11pancreatitis10.5
12influenza10.5
13endotheliitis10.5
14felty's syndrome10.4C4A
15malaria10.4
16blastomycosis10.4
17typhoid fever10.4
18pustulosis palmaris et plantaris10.4ELANE
19congestive heart failure10.3
20severe acute respiratory syndrome10.3
21epiglottitis10.3
22acute pyelonephritis10.3
23malignant histiocytosis10.3
24pulmonary edema10.3
25eosinophilia10.3
26histiocytosis10.3
27myocarditis10.3
28pyelonephritis10.3
29thyroiditis10.3
30hypoxia10.3
31hypothyroidism10.3
32acute cor pulmonale10.2
33cor pulmonale10.2
34systemic lupus erythematosus10.2
35ovarian hyperstimulation syndrome10.2
36pulmonary function10.2
37sickle cell anemia10.2
38kawasaki disease10.2
39pheochromocytoma10.2
40myocardial infarction10.2
41obesity10.2
42bacteremia10.2
43adult t-cell leukemia10.2
44arthritis10.2
45brain injury10.2
46breast reconstruction10.2
47bronchiolitis obliterans10.2
48hepatitis10.2
49leukemia10.2
50lymphomatoid granulomatosis10.2

Graphical network of the top 20 diseases related to Adult Respiratory Distress Syndrome:



Diseases related to adult respiratory distress syndrome

Symptoms for Adult Respiratory Distress Syndrome

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Drugs & Therapeutics for Adult Respiratory Distress Syndrome

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Drug clinical trials:

Search ClinicalTrials for Adult Respiratory Distress Syndrome

Search NIH Clinical Center for Adult Respiratory Distress Syndrome

Inferred drug relations via UMLS60/NDF-RT39:

Genetic Tests for Adult Respiratory Distress Syndrome

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Anatomical Context for Adult Respiratory Distress Syndrome

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MalaCards organs/tissues related to Adult Respiratory Distress Syndrome:

31
Lung, Neutrophil, Endothelial, Brain, Heart, Thyroid, Monocytes, T cells, Bone marrow, Bone, Liver, Breast

LifeMap Discovery
Data from LifeMap, the Embryonic Development and Stem Cells Database

Cells/anatomical compartments in embryo or adult related to Adult Respiratory Distress Syndrome:
id TissueAnatomical CompartmentCell Relevance
1 LungAlveoliAlveolar Epithelial Type 1 Cells Potential therapeutic candidate, affected by disease
2 LungAlveoliAlveolar Epithelial Type 2 Cells Potential therapeutic candidate, affected by disease
3 LungPulmonary Capillary Plexus  Affected by disease

Animal Models for Adult Respiratory Distress Syndrome or affiliated genes

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MGI Mouse Phenotypes related to Adult Respiratory Distress Syndrome:

35
idDescriptionMGI Source AccessionScoreTop Affiliating Genes
1MP:00053877.5IL8, ANGPT2, ELANE, SOD3, SFTPC

Publications for Adult Respiratory Distress Syndrome

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Articles related to Adult Respiratory Distress Syndrome:

(show top 50)    (show all 559)
idTitleAuthorsYear
1
Ventilation during extracorporeal membrane oxygenation for adult respiratory distress syndrome. (25041935)
2014
2
A case of vivax malaria complicated by adult respiratory distress syndrome and successful management with extracorporeal membrane oxygenation. (24327781)
2013
3
Adult respiratory distress syndrome induced by blunt trauma-A dying threat throughout the world? (24398078)
2013
4
The Adult Respiratory Distress Syndrome Cognitive Outcomes Study: long-term neuropsychological function in survivors of acute lung injury. (23714655)
2013
5
Unmasking of tracheomalacia following short-term mechanical ventilation in a patient of adult respiratory distress syndrome. (22701211)
2012
6
The incidence of adult respiratory distress syndrome in patients undergoing off-pump coronary artery bypass grafting surgery. (16390572)
2006
7
Adult respiratory distress syndrome. (15537121)
2004
8
Late-stage adult respiratory distress syndrome caused by severe acute respiratory syndrome: abnormal findings at thin-section CT. (14752179)
2004
9
Successful use of extracorporeal life support in two cases of posttraumatic adult respiratory distress syndrome. (11426130)
2001
10
Hemodynamic stability during arteriovenous carbon dioxide removal for adult respiratory distress syndrome: a prospective randomized outcomes study in adult sheep. (11374759)
2001
11
Surfactant rescue or liquid ventilation for adult respiratory distress syndrome. (11139126)
2000
12
The adult respiratory distress syndrome after dextran infusion as an antithrombotic agent in free TRAM flap breast reconstruction. (10323708)
1999
13
Systemic Fusarium oxysporum infection in an immunocompetent patient with an adult respiratory distress syndrome (ARDS) and extracorporal membrane oxygenation (ECMO). (9670761)
1998
14
Maternal mortality associated with adult respiratory distress syndrome. (9598851)
1998
15
Inhaled nitric oxide for adult respiratory distress syndrome after pulmonary resection. (9930465)
1998
16
Adult respiratory distress syndrome following cardiopulmonary bypass: incidence, prophylaxis and management. (9972899)
1998
17
Adult respiratory distress syndrome in patients with malignant astrocytoma--three case reports. (9259158)
1997
18
A human case of monocytic ehrlichiosis with adult respiratory distress syndrome in northern California. (8764635)
1996
19
Bronchoscopic surfactant administration in patients with severe adult respiratory distress syndrome and sepsis. (8680699)
1996
20
The role of adult respiratory distress syndrome in the multiple organ dysfunction syndrome. (8901951)
1996
21
The 67gallium pulmonary leak index in assessing the severity and course of the adult respiratory distress syndrome. (8797617)
1996
22
Anti-IL-8 autoantibodies in alveolar fluid from patients with the adult respiratory distress syndrome. (8805676)
1996
23
The fibroproliferative phase of late adult respiratory distress syndrome. (7481129)
1995
24
Impairment in gas exchange after granulocyte colony stimulating factor (G-CSF) in a patient with the adult respiratory distress syndrome. (7529154)
1995
25
Inflammatory predictors for the development of the adult respiratory distress syndrome. (7491546)
1995
26
Intracranial hypertension and adult respiratory distress syndrome: usefulness of tracheal gas insufflation. (7473982)
1995
27
von Willebrand factor antigen levels are not predictive for the adult respiratory distress syndrome. (7812545)
1995
28
Plasma elastase levels and the development of the adult respiratory distress syndrome. (7735596)
1995
29
Additive effect on gas exchange of inhaled nitric oxide and intravenous almitrine bismesylate in the adult respiratory distress syndrome. (8046118)
1994
30
Role of selectins in development of adult respiratory distress syndrome. (7518025)
1994
31
Venovenous extracorporeal life support in traumatic bronchial disruption and adult respiratory distress syndrome using surface-heparinized equipment: case report. (8114147)
1994
32
Cytokine, complement, and endotoxin profiles associated with the development of the adult respiratory distress syndrome after severe injury. (8181284)
1994
33
Prognosis of adult respiratory distress syndrome in pediatric patients. (8176578)
1994
34
Prophylactic treatment in the adult respiratory distress syndrome. (7613495)
1994
35
Efficacy of inhaled nitric oxide in a porcine model of adult respiratory distress syndrome. (8304827)
1994
36
Respiratory syncytial virus triggered adult respiratory distress syndrome in infants: a report of two cases. (8163764)
1994
37
Adult respiratory distress syndrome and late death following imipramine overdose: a case report. (7850687)
1994
38
Adult respiratory distress syndrome after attempted strangulation. (8318335)
1993
39
A double-blind, prospective, randomized trial of ketoconazole, a thromboxane synthetase inhibitor, in the prophylaxis of the adult respiratory distress syndrome. (8222677)
1993
40
Endothelin-1 in acute lung injury and the adult respiratory distress syndrome. (8256914)
1993
41
Long-term inhalation with evaluated low doses of nitric oxide for selective improvement of oxygenation in patients with adult respiratory distress syndrome. (8294626)
1993
42
Transfusion-related adult respiratory distress syndrome. (8314693)
1993
43
Newer modes of mechanical ventilation for patients with adult respiratory distress syndrome. (8365232)
1993
44
Inhaled nitric oxide for the adult respiratory distress syndrome. (8357386)
1993
45
Permissive hypercapnia and pressure-controlled ventilation as treatment of severe adult respiratory distress syndrome in a pediatric burn patient. (8504665)
1993
46
Adult respiratory distress syndrome as a complication of postanginal sepsis. (8486067)
1993
47
Neuropeptides in pulmonary edema fluid of adult respiratory distress syndrome. (1428125)
1992
48
Increased serum catalase activity in septic patients with the adult respiratory distress syndrome. (1416429)
1992
49
Fatal adult respiratory distress syndrome following successful treatment of pulmonary strongyloidiasis. (1995245)
1991
50
Oxidant stress and adult respiratory distress syndrome. (2278607)
1990

Variations for Adult Respiratory Distress Syndrome

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Expression for genes affiliated with Adult Respiratory Distress Syndrome

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Search GEO for disease gene expression data for Adult Respiratory Distress Syndrome.

Pathways for genes affiliated with Adult Respiratory Distress Syndrome

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Pathways related to Adult Respiratory Distress Syndrome according to GeneCards Suite gene sharing:

idSuper pathways (with members indented)ScoreTop Affiliating Genes
19.6C4A, IL8

Compounds for genes affiliated with Adult Respiratory Distress Syndrome

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Compounds related to Adult Respiratory Distress Syndrome according to GeneCards Suite gene sharing:

(show all 40)
idCompoundScoreTop Affiliating Genes
1sivelestat sodium hydrate439.9IL8, ELANE
2sivelestat439.9IL8, ELANE
3tlck439.9IL8, ELANE
4cilomilast439.9IL8, ELANE
5gabexate mesilate439.9ELANE, IL8
6ulinastatin439.9IL8, ELANE
7aebsf439.9IL8, ELANE
8gm-csf43 2810.9ELANE, IL8
9fluticasone propionate43 49 59 1212.8IL8, ELANE
10rolipram43 59 2811.8IL8, ELANE
11protamine439.8IL8, ELANE
12n-formylmethionyl-leucylphenylalanine439.8IL8, ELANE
13pentoxifylline43 1210.8IL8, ELANE
14rottlerin439.8ELANE, IL8
15neopterin439.7IL8, ELANE
16aprotinin43 1210.7ELANE, IL8
17leukotriene b443 59 2411.7IL8, ELANE
18doxycycline43 1210.6ELANE, SFTPC
19anaphylatoxin439.5ELANE, IL8, C4A
20endotoxin439.5C4A, IL8, ELANE
21hydrocortisone43 2 59 1212.5IL8, ELANE
22egcg439.5IL8, ELANE
23cyclosporin a43 28 5911.3ELANE, ANGPT2, IL8
24curosurf439.3IL8, ELANE, SFTPC
25survanta439.3IL8, ELANE, SFTPC
26pge2439.3IL8, ANGPT2, ELANE
27alpha tocopherol439.3ELANE, SOD3
28peroxynitrite439.3SOD3, SFTPC
29sodium nitroprusside439.2ELANE, SOD3
30fibrinogen439.2ANGPT2, ELANE, SFTPC
31dexamethasone43 49 28 1212.0SFTPC, ANGPT2, IL8
32superoxide43 2410.0SOD3, ELANE, IL8
33heparin43 28 24 1212.0SOD3, ELANE, IL8
34arginine438.6SFTPC, SOD3, C4A
35h2o2438.6SOD3, ELANE, ANGPT2, IL8
36vegf438.4SFTPC, SOD3, ANGPT2, IL8
37nitric oxide43 24 1210.4IL8, ANGPT2, SOD3
38serine438.2SOD3, ELANE, ANGPT2, IL8, C4A
39cysteine437.9SFTPC, SOD3, ELANE, ANGPT2, IL8
40oxygen43 248.6SFTPC, SOD3, ELANE, ANGPT2, IL8, C4A

GO Terms for genes affiliated with Adult Respiratory Distress Syndrome

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Cellular components related to Adult Respiratory Distress Syndrome according to GeneCards Suite gene sharing:

idNameGO IDScoreTop Affiliating Genes
1extracellular spaceGO:00056158.1IL8, ANGPT2, SOD3, SFTPC
2extracellular regionGO:00055767.5C4A, IL8, ANGPT2, ELANE, SOD3

Biological processes related to Adult Respiratory Distress Syndrome according to GeneCards Suite gene sharing:

idNameGO IDScoreTop Affiliating Genes
1response to lipopolysaccharideGO:00324969.3ELANE, SFTPC
2response to glucoseGO:00097499.2ANGPT2, SFTPC
3leukocyte migrationGO:00509009.1ANGPT2, ELANE

Molecular functions related to Adult Respiratory Distress Syndrome according to GeneCards Suite gene sharing:

idNameGO IDScoreTop Affiliating Genes
1heparin bindingGO:00082019.1ELANE, SOD3

Products for genes affiliated with Adult Respiratory Distress Syndrome

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  • Antibodies
  • Proteins
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  • Antibodies
  • Proteins
  • Kits and Assays

Sources for Adult Respiratory Distress Syndrome

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3CDC
13ExPASy
14FMA
22GTR
23HGMD
24HMDB
25ICD10
26ICD10 via Orphanet
27ICD9CM
28IUPHAR
29KEGG
33MeSH
34MESH via Orphanet
35MGI
38NCIt
39NDF-RT
42NINDS
43Novoseek
45OMIM
46OMIM via Orphanet
50PubMed
51QIAGEN
56SNOMED-CT via Orphanet
60UMLS
61UMLS via Orphanet