ALI
MCID: ADL010
MIFTS: 63

Adult Respiratory Distress Syndrome (ALI) malady

Rare diseases, Respiratory diseases, Cardiovascular diseases categories
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Summaries for Adult Respiratory Distress Syndrome

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Sources:
8Disease Ontology, 43NIH Rare Diseases, 65Wikipedia, 33MalaCards
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NIH Rare Diseases:43 Acute respiratory distress syndrome (ards) is a life-threatening lung condition that prevents enough oxygen from getting to the lungs and into the blood.  people who develop ards often are very ill with another disease or have major injuries. the condition leads to a buildup of fluid in the air sacs which prevents enough oxygen from passing into the bloodstream. symptoms may include difficulty breathing, low blood pressure and organ failure, rapid breathing and shortness of breath. last updated: 5/17/2012

MalaCards: Adult Respiratory Distress Syndrome, also known as non-cardiogenic pulmonary edema, is related to sepsis and pneumonia. An important gene associated with Adult Respiratory Distress Syndrome is C4A (complement component 4A (Rodgers blood group)), and among its related pathways are Pertussis and Selected targets of C EBPbeta. The drugs acetylcysteine and methylprednisolone and the compounds sivelestat sodium hydrate and sivelestat have been mentioned in the context of this disorder. Affiliated tissues include lung, endothelial and brain, and related mouse phenotype immune system.

Disease Ontology:8 A respiratory failure that results from diffuse injury to the endothelium of the lung (as in sepsis, chest trauma, massive blood transfusion, aspiration of the gastric contents, or pneumonia) and is characterized by pulmonary edema with an abnormally high amount of protein in the edematous fluid and by difficult rapid breathing and hypoxemia.

Wikipedia:65 Acute respiratory distress syndrome (\"ARDS\"), previously known as respiratory distress syndrome... more...

Aliases & Classifications for Adult Respiratory Distress Syndrome

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Sources:
8Disease Ontology, 43NIH Rare Diseases, 10DISEASES, 45Novoseek, 49Orphanet, 62UMLS, 58SNOMED-CT, 40NCIt, 35MeSH, 36MESH via Orphanet, 59SNOMED-CT via Orphanet, 63UMLS via Orphanet, 25ICD10
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Classifications:

Malacards categories (disease lists): (See all malacards categories)
Global: Rare diseases
Anatomical: Respiratory diseases, Cardiovascular diseases


Characteristics (Orphanet epidemiological data):

49
acute lung injury:
Prevalence: 1-5/10000


Aliases & Descriptions:

adult respiratory distress syndrome 8 43 10
non-cardiogenic pulmonary edema 8 43 62
respiratory distress syndrome, adult 43 62
acute respiratory distress syndrome 8 43
acute respiratory distress 45 62
acute lung injury 43 49
shock lung 8 43
ards 8 43
increased-permeability pulmonary edema 43
respiratory distress syndrome adult 45
respirat distress synd-adult 8
stiff lung 43
adult rds 8
ali 43


External Ids:

Disease Ontology8 DOID:11394
NCIt40 C3353
MeSH35 D012128
MESH via Orphanet36 D055371
SNOMED-CT via Orphanet59 315345002
UMLS via Orphanet63 C0242488
ICD1025 J80

Related Diseases for Adult Respiratory Distress Syndrome

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Sources:
17GeneCards, 18GeneDecks
See all sources

Diseases in the Adult Respiratory Distress Syndrome family:

Adult Acute Respiratory Distress Syndrome

Diseases related to Adult Respiratory Distress Syndrome via text searches within MalaCards or GeneCards/GeneDecks gene sharing:

(show top 50)    (show all 275)
idRelated DiseaseScoreTop Affiliating Genes
1sepsis31.2ELANE, ANGPT2, IL8, C4A
2pneumonia31.0SFTPC, SOD3, ELANE, IL8
3septic shock31.0IL8, ANGPT2, ELANE
4psoriasis30.7ELANE, ANGPT2, IL8
5rheumatoid arthritis30.5SOD3, ELANE, ANGPT2, IL8
6capillary leak syndrome30.4ELANE
7bronchitis30.3IL8, ELANE
8acute pancreatitis30.3IL8, ELANE
9pulmonary fibrosis30.1IL8, ELANE, SOD3, SFTPC
10idiopathic pulmonary fibrosis30.1SFTPC, ELANE, IL8
11cystic fibrosis30.1SFTPC, ELANE, IL8
12asthma30.0SFTPC, ELANE, ANGPT2, IL8
13miliary tuberculosis10.8
14tuberculosis10.8
15scrub typhus10.7
16typhus10.7
17plasmodium vivax malaria10.6
18hypertension10.6
19cor pulmonale10.5
20pancreatitis10.5
21acute cor pulmonale10.5
22generalized pustular psoriasis10.5
23burns10.5
24influenza10.5
25endotheliitis10.5
26alcohol abuse10.4
27acute interstitial pneumonia10.4
28patent foramen ovale10.4
29arthritis10.4
30disseminated intravascular coagulation10.4
31infant acute respiratory distress syndrome10.4
32diffuse alveolar hemorrhage10.4
33blastomycosis10.4
34malaria10.4
35acute liver failure10.3
36bronchiolitis obliterans organizing pneumonia10.3
37plasmodium ovale malaria10.3
38bronchogenic carcinoma10.3
39cerebral malaria10.3
40critical illness polyneuropathy10.3
41myopathy10.3
42neutropenia10.3
43polyneuropathy10.3
44relapsing fever10.3
45antisynthetase syndrome10.3
46severe acute respiratory syndrome10.3
47epiglottitis10.3
48acute pyelonephritis10.3
49malignant histiocytosis10.3
50pulmonary edema10.3

Graphical network of the top 20 diseases related to Adult Respiratory Distress Syndrome:



Diseases related to adult respiratory distress syndrome

Symptoms for Adult Respiratory Distress Syndrome

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Drugs & Therapeutics for Adult Respiratory Distress Syndrome

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Sources:
42NIH Clinical Center, 6ClinicalTrials, 62UMLS, 41NDF-RT
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Drug clinical trials:

Search ClinicalTrials for Adult Respiratory Distress Syndrome

Search NIH Clinical Center for Adult Respiratory Distress Syndrome

Inferred drug relations via UMLS62/NDF-RT41:

Genetic Tests for Adult Respiratory Distress Syndrome

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Anatomical Context for Adult Respiratory Distress Syndrome

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Sources:
31LifeMap Discovery™, 33MalaCards
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MalaCards organs/tissues related to Adult Respiratory Distress Syndrome:

33
Lung, Endothelial, Brain, Heart, Thyroid, Monocytes, T cells, Liver, Bone, Breast, Bone marrow

LifeMap Discovery
The database of embryonic development, stem cell research and regenerative medicine

Cells/anatomical compartments in embryo or adult related to Adult Respiratory Distress Syndrome:
id TissueAnatomical CompartmentCell Relevance
1 LungAlveoliAlveolar Epithelial Type 1 Cells Potential therapeutic candidate, affected by disease
2 LungAlveoliAlveolar Epithelial Type 2 Cells Potential therapeutic candidate, affected by disease
3 LungPulmonary Capillary Plexus  Affected by disease

Animal Models for Adult Respiratory Distress Syndrome or affiliated genes

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Sources:
37MGI
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MGI Mouse Phenotypes related to Adult Respiratory Distress Syndrome:

37
idDescriptionMGI Source AccessionScoreTop Affiliating Genes
1MP:00053877.5IL8, ANGPT2, ELANE, SOD3, SFTPC

Publications for Adult Respiratory Distress Syndrome

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Sources:
52PubMed
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Articles related to Adult Respiratory Distress Syndrome:

(show top 50)    (show all 542)
idTitleAuthorsYear
1
A case of vivax malaria complicated by adult respiratory distress syndrome and successful management with extracorporeal membrane oxygenation. (24327781)
2013
2
Adult respiratory distress syndrome induced by blunt trauma-A dying threat throughout the world? (24398078)
2013
3
The Adult Respiratory Distress Syndrome Cognitive Outcomes Study: long-term neuropsychological function in survivors of acute lung injury. (23714655)
2013
4
Unmasking of tracheomalacia following short-term mechanical ventilation in a patient of adult respiratory distress syndrome. (22701211)
2012
5
The incidence of adult respiratory distress syndrome in patients undergoing off-pump coronary artery bypass grafting surgery. (16390572)
2006
6
Adult respiratory distress syndrome. (15537121)
2004
7
Late-stage adult respiratory distress syndrome caused by severe acute respiratory syndrome: abnormal findings at thin-section CT. (14752179)
2004
8
Successful use of extracorporeal life support in two cases of posttraumatic adult respiratory distress syndrome. (11426130)
2001
9
Hemodynamic stability during arteriovenous carbon dioxide removal for adult respiratory distress syndrome: a prospective randomized outcomes study in adult sheep. (11374759)
2001
10
Surfactant rescue or liquid ventilation for adult respiratory distress syndrome. (11139126)
2000
11
The adult respiratory distress syndrome after dextran infusion as an antithrombotic agent in free TRAM flap breast reconstruction. (10323708)
1999
12
Systemic Fusarium oxysporum infection in an immunocompetent patient with an adult respiratory distress syndrome (ARDS) and extracorporal membrane oxygenation (ECMO). (9670761)
1998
13
Maternal mortality associated with adult respiratory distress syndrome. (9598851)
1998
14
Inhaled nitric oxide for adult respiratory distress syndrome after pulmonary resection. (9930465)
1998
15
Adult respiratory distress syndrome following cardiopulmonary bypass: incidence, prophylaxis and management. (9972899)
1998
16
Adult respiratory distress syndrome in patients with malignant astrocytoma--three case reports. (9259158)
1997
17
A human case of monocytic ehrlichiosis with adult respiratory distress syndrome in northern California. (8764635)
1996
18
Bronchoscopic surfactant administration in patients with severe adult respiratory distress syndrome and sepsis. (8680699)
1996
19
The role of adult respiratory distress syndrome in the multiple organ dysfunction syndrome. (8901951)
1996
20
The 67gallium pulmonary leak index in assessing the severity and course of the adult respiratory distress syndrome. (8797617)
1996
21
Anti-IL-8 autoantibodies in alveolar fluid from patients with the adult respiratory distress syndrome. (8805676)
1996
22
The fibroproliferative phase of late adult respiratory distress syndrome. (7481129)
1995
23
Impairment in gas exchange after granulocyte colony stimulating factor (G-CSF) in a patient with the adult respiratory distress syndrome. (7529154)
1995
24
Inflammatory predictors for the development of the adult respiratory distress syndrome. (7491546)
1995
25
Intracranial hypertension and adult respiratory distress syndrome: usefulness of tracheal gas insufflation. (7473982)
1995
26
von Willebrand factor antigen levels are not predictive for the adult respiratory distress syndrome. (7812545)
1995
27
Plasma elastase levels and the development of the adult respiratory distress syndrome. (7735596)
1995
28
Additive effect on gas exchange of inhaled nitric oxide and intravenous almitrine bismesylate in the adult respiratory distress syndrome. (8046118)
1994
29
Role of selectins in development of adult respiratory distress syndrome. (7518025)
1994
30
Venovenous extracorporeal life support in traumatic bronchial disruption and adult respiratory distress syndrome using surface-heparinized equipment: case report. (8114147)
1994
31
Cytokine, complement, and endotoxin profiles associated with the development of the adult respiratory distress syndrome after severe injury. (8181284)
1994
32
Prognosis of adult respiratory distress syndrome in pediatric patients. (8176578)
1994
33
Prophylactic treatment in the adult respiratory distress syndrome. (7613495)
1994
34
Efficacy of inhaled nitric oxide in a porcine model of adult respiratory distress syndrome. (8304827)
1994
35
Respiratory syncytial virus triggered adult respiratory distress syndrome in infants: a report of two cases. (8163764)
1994
36
Adult respiratory distress syndrome and late death following imipramine overdose: a case report. (7850687)
1994
37
Evaluation of definitions for adult respiratory distress syndrome. (8049808)
1994
38
Adult respiratory distress syndrome after attempted strangulation. (8318335)
1993
39
A double-blind, prospective, randomized trial of ketoconazole, a thromboxane synthetase inhibitor, in the prophylaxis of the adult respiratory distress syndrome. (8222677)
1993
40
Endothelin-1 in acute lung injury and the adult respiratory distress syndrome. (8256914)
1993
41
Long-term inhalation with evaluated low doses of nitric oxide for selective improvement of oxygenation in patients with adult respiratory distress syndrome. (8294626)
1993
42
Transfusion-related adult respiratory distress syndrome. (8314693)
1993
43
Newer modes of mechanical ventilation for patients with adult respiratory distress syndrome. (8365232)
1993
44
Inhaled nitric oxide for the adult respiratory distress syndrome. (8357386)
1993
45
Permissive hypercapnia and pressure-controlled ventilation as treatment of severe adult respiratory distress syndrome in a pediatric burn patient. (8504665)
1993
46
Adult respiratory distress syndrome as a complication of postanginal sepsis. (8486067)
1993
47
Neuropeptides in pulmonary edema fluid of adult respiratory distress syndrome. (1428125)
1992
48
Increased serum catalase activity in septic patients with the adult respiratory distress syndrome. (1416429)
1992
49
Fatal adult respiratory distress syndrome following successful treatment of pulmonary strongyloidiasis. (1995245)
1991
50
Oxidant stress and adult respiratory distress syndrome. (2278607)
1990

Variations for Adult Respiratory Distress Syndrome

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Expression for genes affiliated with Adult Respiratory Distress Syndrome

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Sources:
2BioGPS, 15Gene Expression Omnibus DataSets
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Expression patterns in normal tissues for genes affiliated with Adult Respiratory Distress Syndrome

Search GEO for disease gene expression data for Adult Respiratory Distress Syndrome.

Pathways for genes affiliated with Adult Respiratory Distress Syndrome

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Sources:
50PathCards, 30KEGG, 12EMD Millipore
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Pathways related to Adult Respiratory Distress Syndrome according to GeneCards/GeneDecks:

idSuper pathways (with members indented)ScoreTop Affiliating Genes
19.6C4A, IL8
29.1ELANE, SOD3

Compounds for genes affiliated with Adult Respiratory Distress Syndrome

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Sources:
45Novoseek, 29IUPHAR, 51PharmGKB, 61Tocris Bioscience, 11DrugBank, 24HMDB, 3BitterDB
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Compounds related to Adult Respiratory Distress Syndrome according to GeneCards/GeneDecks:

(show all 40)
idCompoundScoreTop Affiliating Genes
1sivelestat sodium hydrate459.9IL8, ELANE
2sivelestat459.9IL8, ELANE
3tlck459.9IL8, ELANE
4cilomilast459.9IL8, ELANE
5gabexate mesilate459.9ELANE, IL8
6ulinastatin459.9IL8, ELANE
7aebsf459.9IL8, ELANE
8gm-csf45 2910.9ELANE, IL8
9fluticasone propionate45 51 61 1112.8IL8, ELANE
10rolipram45 61 2911.8IL8, ELANE
11protamine459.8IL8, ELANE
12n-formylmethionyl-leucylphenylalanine459.8IL8, ELANE
13pentoxifylline45 1110.8IL8, ELANE
14rottlerin459.8ELANE, IL8
15neopterin459.7IL8, ELANE
16aprotinin45 1110.7ELANE, IL8
17leukotriene b445 61 2411.7IL8, ELANE
18doxycycline45 1110.6ELANE, SFTPC
19anaphylatoxin459.5ELANE, IL8, C4A
20endotoxin459.5C4A, IL8, ELANE
21hydrocortisone45 3 61 1112.5IL8, ELANE
22egcg459.5IL8, ELANE
23cyclosporin a45 29 6111.3ELANE, ANGPT2, IL8
24curosurf459.3IL8, ELANE, SFTPC
25survanta459.3IL8, ELANE, SFTPC
26pge2459.3IL8, ANGPT2, ELANE
27alpha tocopherol459.3ELANE, SOD3
28peroxynitrite459.3SOD3, SFTPC
29sodium nitroprusside459.2ELANE, SOD3
30fibrinogen459.2ANGPT2, ELANE, SFTPC
31dexamethasone45 51 29 1112.0SFTPC, ANGPT2, IL8
32superoxide45 2410.0SOD3, ELANE, IL8
33heparin45 29 24 1112.0SOD3, ELANE, IL8
34arginine458.6SFTPC, SOD3, C4A
35h2o2458.6SOD3, ELANE, ANGPT2, IL8
36vegf458.4SFTPC, SOD3, ANGPT2, IL8
37nitric oxide45 24 1110.4IL8, ANGPT2, SOD3
38serine458.2SOD3, ELANE, ANGPT2, IL8, C4A
39cysteine457.9SFTPC, SOD3, ELANE, ANGPT2, IL8
40oxygen45 248.6SFTPC, SOD3, ELANE, ANGPT2, IL8, C4A

GO Terms for genes affiliated with Adult Respiratory Distress Syndrome

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Sources:
16Gene Ontology
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Cellular components related to Adult Respiratory Distress Syndrome according to GeneCards/GeneDecks:

idNameGO IDScoreTop Affiliating Genes
1extracellular spaceGO:0056158.1IL8, ANGPT2, SOD3, SFTPC
2extracellular regionGO:0055767.5C4A, IL8, ANGPT2, ELANE, SOD3

Biological processes related to Adult Respiratory Distress Syndrome according to GeneCards/GeneDecks:

idNameGO IDScoreTop Affiliating Genes
1response to lipopolysaccharideGO:0324969.3ELANE, SFTPC
2response to glucoseGO:0097499.2ANGPT2, SFTPC
3leukocyte migrationGO:0509009.1ANGPT2, ELANE

Molecular functions related to Adult Respiratory Distress Syndrome according to GeneCards/GeneDecks:

idNameGO IDScoreTop Affiliating Genes
1heparin bindingGO:0082019.1ELANE, SOD3

Products for genes affiliated with Adult Respiratory Distress Syndrome

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  • Antibodies
  • Proteins
  • Lysates
  • Antibodies

Sources for Adult Respiratory Distress Syndrome

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4CDC
13ExPASy
14FMA
22GTR
23HGMD
24HMDB
25ICD10
26ICD10 via Orphanet
27ICD9CM
29IUPHAR
30KEGG
35MeSH
36MESH via Orphanet
37MGI
40NCIt
41NDF-RT
44NINDS
45Novoseek
47OMIM
48OMIM via Orphanet
52PubMed
53QIAGEN
59SNOMED-CT via Orphanet
62UMLS
63UMLS via Orphanet