ALI
MCID: ADL010
MIFTS: 63

Adult Respiratory Distress Syndrome (ALI) malady

Rare diseases, Respiratory diseases, Cardiovascular diseases categories

Summaries for Adult Respiratory Distress Syndrome

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Sources:
9Disease Ontology, 44NIH Rare Diseases, 66Wikipedia, 34MalaCards
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NIH Rare Diseases:44 Acute respiratory distress syndrome (ards) is a life-threatening lung condition that prevents enough oxygen from getting to the lungs and into the blood.  people who develop ards often are very ill with another disease or have major injuries. the condition leads to a buildup of fluid in the air sacs which prevents enough oxygen from passing into the bloodstream. symptoms may include difficulty breathing, low blood pressure and organ failure, rapid breathing and shortness of breath. last updated: 5/17/2012

MalaCards: Adult Respiratory Distress Syndrome, also known as non-cardiogenic pulmonary edema, is related to sepsis and pneumonia. An important gene associated with Adult Respiratory Distress Syndrome is C4A (complement component 4A (Rodgers blood group)), and among its related pathways are Pertussis and Selected targets of C EBPbeta. The drugs acetylcysteine and methylprednisolone and the compounds sivelestat sodium hydrate and sivelestat have been mentioned in the context of this disorder. Affiliated tissues include lung, endothelial and brain, and related mouse phenotype immune system.

Disease Ontology:9 A respiratory failure that results from diffuse injury to the endothelium of the lung (as in sepsis, chest trauma, massive blood transfusion, aspiration of the gastric contents, or pneumonia) and is characterized by pulmonary edema with an abnormally high amount of protein in the edematous fluid and by difficult rapid breathing and hypoxemia.

Wikipedia:66 Acute respiratory distress syndrome (\"ARDS\"), previously known as respiratory distress syndrome... more...

Aliases & Classifications for Adult Respiratory Distress Syndrome

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Sources:
9Disease Ontology, 44NIH Rare Diseases, 11DISEASES, 46Novoseek, 50Orphanet, 63UMLS, 59SNOMED-CT, 41NCIt, 36MeSH, 37MESH via Orphanet, 60SNOMED-CT via Orphanet, 64UMLS via Orphanet, 26ICD10
See all sources

Classifications:

Malacards categories (disease lists): (See all malacards categories)
Global: Rare diseases
Anatomical: Respiratory diseases, Cardiovascular diseases


Characteristics (Orphanet epidemiological data):

50
acute lung injury:
Prevalence: 1-5/10000


Aliases & Descriptions:

adult respiratory distress syndrome 9 44 11
non-cardiogenic pulmonary edema 9 44 63
respiratory distress syndrome, adult 44 63
acute respiratory distress syndrome 9 44
acute respiratory distress 46 63
acute lung injury 44 50
shock lung 9 44
ards 9 44
increased-permeability pulmonary edema 44
respiratory distress syndrome adult 46
respirat distress synd-adult 9
stiff lung 44
adult rds 9
ali 44


External Ids:

Disease Ontology9 DOID:11394
NCIt41 C3353
MeSH36 D012128
MESH via Orphanet37 D055371
SNOMED-CT via Orphanet60 315345002
UMLS via Orphanet64 C0242488
ICD1026 J80

Related Diseases for Adult Respiratory Distress Syndrome

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Sources:
18GeneCards, 19GeneDecks
See all sources

Diseases in the Adult Respiratory Distress Syndrome family:

Adult Acute Respiratory Distress Syndrome

Diseases related to Adult Respiratory Distress Syndrome via text searches within MalaCards or GeneCards/GeneDecks gene sharing:

(show top 50)    (show all 275)
idRelated DiseaseScoreTop Affiliating Genes
1sepsis31.2ELANE, ANGPT2, IL8, C4A
2pneumonia31.0SFTPC, SOD3, ELANE, IL8
3septic shock31.0IL8, ANGPT2, ELANE
4psoriasis30.7ELANE, ANGPT2, IL8
5rheumatoid arthritis30.5SOD3, ELANE, ANGPT2, IL8
6capillary leak syndrome30.4ELANE
7bronchitis30.3IL8, ELANE
8acute pancreatitis30.3IL8, ELANE
9pulmonary fibrosis30.1IL8, ELANE, SOD3, SFTPC
10idiopathic pulmonary fibrosis30.1SFTPC, ELANE, IL8
11cystic fibrosis30.1SFTPC, ELANE, IL8
12asthma30.0SFTPC, ELANE, ANGPT2, IL8
13miliary tuberculosis10.8
14tuberculosis10.8
15scrub typhus10.7
16typhus10.7
17plasmodium vivax malaria10.6
18hypertension10.6
19cor pulmonale10.5
20pancreatitis10.5
21acute cor pulmonale10.5
22generalized pustular psoriasis10.5
23burns10.5
24influenza10.5
25endotheliitis10.5
26alcohol abuse10.4
27acute interstitial pneumonia10.4
28patent foramen ovale10.4
29arthritis10.4
30disseminated intravascular coagulation10.4
31infant acute respiratory distress syndrome10.4
32diffuse alveolar hemorrhage10.4
33blastomycosis10.4
34malaria10.4
35acute liver failure10.3
36bronchiolitis obliterans organizing pneumonia10.3
37plasmodium ovale malaria10.3
38bronchogenic carcinoma10.3
39cerebral malaria10.3
40critical illness polyneuropathy10.3
41myopathy10.3
42neutropenia10.3
43polyneuropathy10.3
44relapsing fever10.3
45antisynthetase syndrome10.3
46severe acute respiratory syndrome10.3
47epiglottitis10.3
48acute pyelonephritis10.3
49malignant histiocytosis10.3
50pulmonary edema10.3

Graphical network of the top 20 diseases related to Adult Respiratory Distress Syndrome:



Diseases related to adult respiratory distress syndrome

Symptoms for Adult Respiratory Distress Syndrome

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Drugs & Therapeutics for Adult Respiratory Distress Syndrome

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Sources:
6CenterWatch, 43NIH Clinical Center, 7ClinicalTrials, 63UMLS, 42NDF-RT
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Approved drugs:

Search CenterWatch for Adult Respiratory Distress Syndrome

Drug clinical trials:

Search ClinicalTrials for Adult Respiratory Distress Syndrome

Search NIH Clinical Center for Adult Respiratory Distress Syndrome

Search CenterWatch for Adult Respiratory Distress Syndrome

Inferred drug relations via UMLS63/NDF-RT42:

Genetic Tests for Adult Respiratory Distress Syndrome

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Anatomical Context for Adult Respiratory Distress Syndrome

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Sources:
32LifeMap Discovery™, 34MalaCards
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MalaCards organs/tissues related to Adult Respiratory Distress Syndrome:

34
Lung, Endothelial, Brain, Heart, Thyroid, Monocytes, T cells, Liver, Bone, Breast, Bone marrow

LifeMap Discovery
The database of embryonic development, stem cell research and regenerative medicine

Cells/anatomical compartments in embryo or adult related to Adult Respiratory Distress Syndrome:
id TissueAnatomical CompartmentCell Relevance
1 LungAlveoliAlveolar Epithelial Type 1 Cells Potential therapeutic candidate, affected by disease
2 LungAlveoliAlveolar Epithelial Type 2 Cells Potential therapeutic candidate, affected by disease
3 LungPulmonary Capillary Plexus  Affected by disease

Animal Models for Adult Respiratory Distress Syndrome or affiliated genes

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Sources:
38MGI
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MGI Mouse Phenotypes related to Adult Respiratory Distress Syndrome:

38
idDescriptionMGI Source AccessionScoreTop Affiliating Genes
1MP:00053877.5IL8, ANGPT2, ELANE, SOD3, SFTPC

Publications for Adult Respiratory Distress Syndrome

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Sources:
53PubMed
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Articles related to Adult Respiratory Distress Syndrome:

(show top 50)    (show all 542)
idTitleAuthorsYear
1
A case of vivax malaria complicated by adult respiratory distress syndrome and successful management with extracorporeal membrane oxygenation. (24327781)
2013
2
Adult respiratory distress syndrome induced by blunt trauma-A dying threat throughout the world? (24398078)
2013
3
The Adult Respiratory Distress Syndrome Cognitive Outcomes Study: long-term neuropsychological function in survivors of acute lung injury. (23714655)
2013
4
Unmasking of tracheomalacia following short-term mechanical ventilation in a patient of adult respiratory distress syndrome. (22701211)
2012
5
The incidence of adult respiratory distress syndrome in patients undergoing off-pump coronary artery bypass grafting surgery. (16390572)
2006
6
Adult respiratory distress syndrome. (15537121)
2004
7
Late-stage adult respiratory distress syndrome caused by severe acute respiratory syndrome: abnormal findings at thin-section CT. (14752179)
2004
8
Successful use of extracorporeal life support in two cases of posttraumatic adult respiratory distress syndrome. (11426130)
2001
9
Hemodynamic stability during arteriovenous carbon dioxide removal for adult respiratory distress syndrome: a prospective randomized outcomes study in adult sheep. (11374759)
2001
10
Surfactant rescue or liquid ventilation for adult respiratory distress syndrome. (11139126)
2000
11
The adult respiratory distress syndrome after dextran infusion as an antithrombotic agent in free TRAM flap breast reconstruction. (10323708)
1999
12
Systemic Fusarium oxysporum infection in an immunocompetent patient with an adult respiratory distress syndrome (ARDS) and extracorporal membrane oxygenation (ECMO). (9670761)
1998
13
Maternal mortality associated with adult respiratory distress syndrome. (9598851)
1998
14
Inhaled nitric oxide for adult respiratory distress syndrome after pulmonary resection. (9930465)
1998
15
Adult respiratory distress syndrome following cardiopulmonary bypass: incidence, prophylaxis and management. (9972899)
1998
16
Adult respiratory distress syndrome in patients with malignant astrocytoma--three case reports. (9259158)
1997
17
A human case of monocytic ehrlichiosis with adult respiratory distress syndrome in northern California. (8764635)
1996
18
Bronchoscopic surfactant administration in patients with severe adult respiratory distress syndrome and sepsis. (8680699)
1996
19
The role of adult respiratory distress syndrome in the multiple organ dysfunction syndrome. (8901951)
1996
20
The 67gallium pulmonary leak index in assessing the severity and course of the adult respiratory distress syndrome. (8797617)
1996
21
Anti-IL-8 autoantibodies in alveolar fluid from patients with the adult respiratory distress syndrome. (8805676)
1996
22
The fibroproliferative phase of late adult respiratory distress syndrome. (7481129)
1995
23
Impairment in gas exchange after granulocyte colony stimulating factor (G-CSF) in a patient with the adult respiratory distress syndrome. (7529154)
1995
24
Inflammatory predictors for the development of the adult respiratory distress syndrome. (7491546)
1995
25
Intracranial hypertension and adult respiratory distress syndrome: usefulness of tracheal gas insufflation. (7473982)
1995
26
von Willebrand factor antigen levels are not predictive for the adult respiratory distress syndrome. (7812545)
1995
27
Plasma elastase levels and the development of the adult respiratory distress syndrome. (7735596)
1995
28
Additive effect on gas exchange of inhaled nitric oxide and intravenous almitrine bismesylate in the adult respiratory distress syndrome. (8046118)
1994
29
Role of selectins in development of adult respiratory distress syndrome. (7518025)
1994
30
Venovenous extracorporeal life support in traumatic bronchial disruption and adult respiratory distress syndrome using surface-heparinized equipment: case report. (8114147)
1994
31
Cytokine, complement, and endotoxin profiles associated with the development of the adult respiratory distress syndrome after severe injury. (8181284)
1994
32
Prognosis of adult respiratory distress syndrome in pediatric patients. (8176578)
1994
33
Prophylactic treatment in the adult respiratory distress syndrome. (7613495)
1994
34
Efficacy of inhaled nitric oxide in a porcine model of adult respiratory distress syndrome. (8304827)
1994
35
Respiratory syncytial virus triggered adult respiratory distress syndrome in infants: a report of two cases. (8163764)
1994
36
Adult respiratory distress syndrome and late death following imipramine overdose: a case report. (7850687)
1994
37
Evaluation of definitions for adult respiratory distress syndrome. (8049808)
1994
38
Adult respiratory distress syndrome after attempted strangulation. (8318335)
1993
39
A double-blind, prospective, randomized trial of ketoconazole, a thromboxane synthetase inhibitor, in the prophylaxis of the adult respiratory distress syndrome. (8222677)
1993
40
Endothelin-1 in acute lung injury and the adult respiratory distress syndrome. (8256914)
1993
41
Long-term inhalation with evaluated low doses of nitric oxide for selective improvement of oxygenation in patients with adult respiratory distress syndrome. (8294626)
1993
42
Transfusion-related adult respiratory distress syndrome. (8314693)
1993
43
Newer modes of mechanical ventilation for patients with adult respiratory distress syndrome. (8365232)
1993
44
Inhaled nitric oxide for the adult respiratory distress syndrome. (8357386)
1993
45
Permissive hypercapnia and pressure-controlled ventilation as treatment of severe adult respiratory distress syndrome in a pediatric burn patient. (8504665)
1993
46
Adult respiratory distress syndrome as a complication of postanginal sepsis. (8486067)
1993
47
Neuropeptides in pulmonary edema fluid of adult respiratory distress syndrome. (1428125)
1992
48
Increased serum catalase activity in septic patients with the adult respiratory distress syndrome. (1416429)
1992
49
Fatal adult respiratory distress syndrome following successful treatment of pulmonary strongyloidiasis. (1995245)
1991
50
Oxidant stress and adult respiratory distress syndrome. (2278607)
1990

Variations for Adult Respiratory Distress Syndrome

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Expression for genes affiliated with Adult Respiratory Distress Syndrome

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Sources:
2BioGPS, 16Gene Expression Omnibus DataSets
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Expression patterns in normal tissues for genes affiliated with Adult Respiratory Distress Syndrome

Search GEO for disease gene expression data for Adult Respiratory Distress Syndrome.

Pathways for genes affiliated with Adult Respiratory Distress Syndrome

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Sources:
51PathCards, 31KEGG, 13EMD Millipore
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Pathways related to Adult Respiratory Distress Syndrome according to GeneCards/GeneDecks:

idSuper pathways (with members indented)ScoreTop Affiliating Genes
19.6C4A, IL8
29.1ELANE, SOD3

Compounds for genes affiliated with Adult Respiratory Distress Syndrome

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Sources:
46Novoseek, 30IUPHAR, 52PharmGKB, 62Tocris Bioscience, 12DrugBank, 25HMDB, 3BitterDB
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Compounds related to Adult Respiratory Distress Syndrome according to GeneCards/GeneDecks:

(show all 40)
idCompoundScoreTop Affiliating Genes
1sivelestat sodium hydrate469.9IL8, ELANE
2sivelestat469.9IL8, ELANE
3tlck469.9IL8, ELANE
4cilomilast469.9IL8, ELANE
5gabexate mesilate469.9ELANE, IL8
6ulinastatin469.9IL8, ELANE
7aebsf469.9IL8, ELANE
8gm-csf46 3010.9ELANE, IL8
9fluticasone propionate46 52 62 1212.8IL8, ELANE
10rolipram46 62 3011.8IL8, ELANE
11protamine469.8IL8, ELANE
12n-formylmethionyl-leucylphenylalanine469.8IL8, ELANE
13pentoxifylline46 1210.8IL8, ELANE
14rottlerin469.8ELANE, IL8
15neopterin469.7IL8, ELANE
16aprotinin46 1210.7ELANE, IL8
17leukotriene b446 62 2511.7IL8, ELANE
18doxycycline46 1210.6ELANE, SFTPC
19anaphylatoxin469.5ELANE, IL8, C4A
20endotoxin469.5C4A, IL8, ELANE
21hydrocortisone46 3 62 1212.5IL8, ELANE
22egcg469.5IL8, ELANE
23cyclosporin a46 30 6211.3ELANE, ANGPT2, IL8
24curosurf469.3IL8, ELANE, SFTPC
25survanta469.3IL8, ELANE, SFTPC
26pge2469.3IL8, ANGPT2, ELANE
27alpha tocopherol469.3ELANE, SOD3
28peroxynitrite469.3SOD3, SFTPC
29sodium nitroprusside469.2ELANE, SOD3
30fibrinogen469.2ANGPT2, ELANE, SFTPC
31dexamethasone46 52 30 1212.0SFTPC, ANGPT2, IL8
32superoxide46 2510.0SOD3, ELANE, IL8
33heparin46 30 25 1212.0SOD3, ELANE, IL8
34arginine468.6SFTPC, SOD3, C4A
35h2o2468.6SOD3, ELANE, ANGPT2, IL8
36vegf468.4SFTPC, SOD3, ANGPT2, IL8
37nitric oxide46 25 1210.4IL8, ANGPT2, SOD3
38serine468.2SOD3, ELANE, ANGPT2, IL8, C4A
39cysteine467.9SFTPC, SOD3, ELANE, ANGPT2, IL8
40oxygen46 258.6SFTPC, SOD3, ELANE, ANGPT2, IL8, C4A

GO Terms for genes affiliated with Adult Respiratory Distress Syndrome

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Sources:
17Gene Ontology
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Cellular components related to Adult Respiratory Distress Syndrome according to GeneCards/GeneDecks:

idNameGO IDScoreTop Affiliating Genes
1extracellular spaceGO:0056158.1IL8, ANGPT2, SOD3, SFTPC
2extracellular regionGO:0055767.5C4A, IL8, ANGPT2, ELANE, SOD3

Biological processes related to Adult Respiratory Distress Syndrome according to GeneCards/GeneDecks:

idNameGO IDScoreTop Affiliating Genes
1response to lipopolysaccharideGO:0324969.3ELANE, SFTPC
2response to glucoseGO:0097499.2ANGPT2, SFTPC
3leukocyte migrationGO:0509009.1ANGPT2, ELANE

Molecular functions related to Adult Respiratory Distress Syndrome according to GeneCards/GeneDecks:

idNameGO IDScoreTop Affiliating Genes
1heparin bindingGO:0082019.1ELANE, SOD3

Products for genes affiliated with Adult Respiratory Distress Syndrome

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  • Antibodies
  • Proteins
  • Lysates
  • Antibodies

Sources for Adult Respiratory Distress Syndrome

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4CDC
14ExPASy
15FMA
23GTR
24HGMD
25HMDB
26ICD10
27ICD10 via Orphanet
28ICD9CM
30IUPHAR
31KEGG
36MeSH
37MESH via Orphanet
38MGI
41NCIt
42NDF-RT
45NINDS
46Novoseek
48OMIM
49OMIM via Orphanet
53PubMed
54QIAGEN
60SNOMED-CT via Orphanet
63UMLS
64UMLS via Orphanet