ALI
MCID: ADL010
MIFTS: 66

Adult Respiratory Distress Syndrome (ALI) malady

Respiratory, Cardiovascular categories

Summaries for Adult Respiratory Distress Syndrome

Sources:
8Disease Ontology, 43NIH Rare Diseases, 64Wikipedia, 33MalaCards
See all sources

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NIH Rare Diseases:43 Acute respiratory distress syndrome (ards) is a life-threatening lung condition that prevents enough oxygen from getting to the lungs and into the blood.  people who develop ards often are very ill with another disease or have major injuries. the condition leads to a buildup of fluid in the air sacs which prevents enough oxygen from passing into the bloodstream. symptoms may include difficulty breathing, low blood pressure and organ failure, rapid breathing and shortness of breath. last updated: 5/17/2012

MalaCards: Adult Respiratory Distress Syndrome, also known as acute respiratory distress syndrome, is related to sepsis and tuberculosis. An important gene associated with Adult Respiratory Distress Syndrome is IL8 (interleukin 8), and among its related pathways are Activation of C3 and C5 and Collagen biosynthesis and modifying enzymes. The drugs acetylcysteine and methylprednisolone and the compounds pge2 and alpha tocopherol have been mentioned in the context of this disorder. Affiliated tissues include bone marrow, brain and heart, and related mouse phenotypes are skeleton and cardiovascular system.

Disease Ontology:8 A respiratory failure that results from diffuse injury to the endothelium of the lung (as in sepsis, chest trauma, massive blood transfusion, aspiration of the gastric contents, or pneumonia) and is characterized by pulmonary edema with an abnormally high amount of protein in the edematous fluid and by difficult rapid breathing and hypoxemia.

Wikipedia:64 Acute respiratory distress syndrome (ARDS), also known as respiratory distress syndrome (RDS) or adult... more...

Aliases & Classifications for Adult Respiratory Distress Syndrome

Sources:
8Disease Ontology, 43NIH Rare Diseases, 10DISEASES, 45Novoseek, 49Orphanet, 61UMLS, 57SNOMED-CT, 35MeSH, 40NCIt, 36MESH via Orphanet, 58SNOMED-CT via Orphanet, 62UMLS via Orphanet, 25ICD10
See all sources

Classifications:

Malacards categories (disease lists): (See all malacards categories)
Anatomical: Respiratory, Cardiovascular


Characteristics (Orphanet epidemiological data):

49
acute lung injury:
Prevalence: 1-5/10000


Aliases & Descriptions:

adult respiratory distress syndrome 8 43 10
acute respiratory distress syndrome 8 43
non-cardiogenic pulmonary edema 8 61
acute respiratory distress 45 61
acute lung injury 43 49
ards 8 43
increased-permeability pulmonary edema 43
respiratory distress syndrome, adult 61
respiratory distress syndrome adult 45
respirat distress synd-adult 8
shock lung 8
adult rds 8
ali 43


External Ids:

Disease Ontology8 DOID:11394
MeSH35 D012128
NCIt40 C3353
MESH via Orphanet36 D055371
SNOMED-CT via Orphanet58 315345002
UMLS via Orphanet62 C0242488
ICD1025 J80

Related Diseases for Adult Respiratory Distress Syndrome

Sources:
17GeneCards, 18GeneDecks
See all sources

Diseases in the Adult Respiratory Distress Syndrome family:

adult acute respiratory distress syndrome

Diseases related to Adult Respiratory Distress Syndrome via text searches within MalaCards or GeneCards/GeneDecks gene sharing:

(show top 50)    (show all 375)
idRelated DiseaseScoreTop Affiliating Genes
1sepsis31.2FGA, CD14, ANGPT2, C4A, TNF, CXCL1
2tuberculosis31.2CP, C5AR1, TNF
3septic shock31.0ELANE, ADRB2, C5AR1, PLA2G6, IL8, IL1R1
4newborn respiratory distress syndrome30.4IL8, CP, ELANE
5sickle cell disease30.3ANGPT2, FGA
6bronchiolitis30.2IL8
7familial mediterranean fever30.2TNF
8aspergillosis30.2ELANE
9capillary leak syndrome30.2ELANE
10kawasaki disease30.2ELANE
11wilson disease30.2CP, CAT
12wegener's granulomatosis30.2ELN, ELANE, CD14
13astrocytoma30.2ANGPT2, CXCL1, PLA2G6
14thrombocytopenia30.2BCHE, IL1R1, FGA
15pulmonary tuberculosis30.2CAT, CD14, CP
16acute leukemia30.2FGA, CD14
17acute pancreatitis30.2CD14, IL1R1, IL8, PLA2G6, ELANE
18coronary artery disease,30.2SOD3, CD14, FGA, BCHE, ADRB2
19pulmonary disease, chronic obstructive30.2SOD3, TNF, IL8, C5AR1, ADRB2, ELANE
20systemic lupus erythematosus30.2TNF, C4A, FGA, IL1R1, C5AR1, ADRB2
21uremia30.1PLA2G6
22idiopathic pulmonary fibrosis30.1CXCL1, IL1R1, IL8, ELANE
23cystic fibrosis30.1IL1R1, IL8, PLA2G6, BCHE, ADRB2, CP
24asthma30.1PLA2G6, IL8, CXCL1, CD14, ANGPT2, TNF
25hepatitis c29.8IL1R1
26vasculitis29.8ELANE, CXCL1, FGA, CD14, TNF
27arthritis29.8SOD3, TNF, CXCL1, IL1R1, IL8, PLA2G6
28adult syndrome11.5
29n syndrome11.1
30adult acute respiratory distress syndrome10.9
31miliary tuberculosis10.8
32generalized pustular psoriasis10.5
33respiratory distress syndrome, infant10.5
34patent foramen ovale10.4
35diffuse alveolar hemorrhage10.4
36blastomycosis10.4
37adult lymphoma10.4
38short syndrome10.4
39acute liver failure10.3
40critical illness polyneuropathy10.3
41bronchogenic carcinoma10.3
42antisynthetase syndrome10.3
43antiphospholipid syndrome10.3
44severe acute respiratory syndrome10.3
45pulmonary edema10.3
46acute pyelonephritis10.3
47epiglottitis10.3
48malignant histiocytosis10.3
49typhoid fever10.3
50spotted fever10.3

Graphical network of the top 20 diseases related to Adult Respiratory Distress Syndrome:



Diseases related to adult respiratory distress syndrome

Clinical Features for Adult Respiratory Distress Syndrome

Drugs & Therapeutics for Adult Respiratory Distress Syndrome

Sources:
5CenterWatch, 42NIH Clinical Center, 6ClinicalTrials, 61UMLS, 41NDF-RT
See all sources

Approved drugs:

Search CenterWatch for Adult Respiratory Distress Syndrome

Drug clinical trials:

Search ClinicalTrials for Adult Respiratory Distress Syndrome

Search NIH Clinical Center for Adult Respiratory Distress Syndrome

Search CenterWatch for Adult Respiratory Distress Syndrome

Inferred drug relations via UMLS61/NDF-RT41:

Genetic Tests for Adult Respiratory Distress Syndrome

Anatomical Context for Adult Respiratory Distress Syndrome

Sources:
31LifeMap Discovery™, 33MalaCards
See all sources

MalaCards organs/tissues related to Adult Respiratory Distress Syndrome:

33
Bone marrow, Brain, Heart, Liver, Lung, Thyroid, Breast, Monocytes, T cells, B cells, Endothelial, Bronchial epithelium

LifeMap Discovery
The database of embryonic development, stem cell research and regenerative medicine

Cells/anatomical compartments in embryo or adult related to Adult Respiratory Distress Syndrome:
id TissueAnatomical CompartmentCell Relevance
1 LungAlveoliAlveolar Epithelial Type 1 Cells Potential therapeutic candidate, affected by disease
2 LungAlveoliAlveolar Epithelial Type 2 Cells Potential therapeutic candidate, affected by disease
3 LungPulmonary Capillary Plexus  Affected by disease

Animal Models for Adult Respiratory Distress Syndrome or affiliated genes

Sources:
37MGI, 28inGenious Targeting Laboratory
See all sources

MGI Mouse Phenotypes related to Adult Respiratory Distress Syndrome:

37
idDescriptionMGI Source AccessionScoreTop Affiliating Genes
1MP:00053909.6SOD3, CD14, FGA, PLA2G6, C5AR1, C5
2MP:00053859.4ANGPT2, FGA, CXCL1, IL1R1, ADRB2, CP
3MP:00053979.0TNF, FGA, IL1R1, IL8, PLA2G6, C5AR1
4MP:00053879.0ELANE, SOD3, TNF, ANGPT2, CD14, FGA
5MP:00107688.8CAT, SOD3, TNF, ANGPT2, CD14, FGA
6MP:00053768.7FGA, CD14, ANGPT2, TNF, SOD3, CAT

Publications for Adult Respiratory Distress Syndrome

Sources:
51PubMed
See all sources

Articles related to Adult Respiratory Distress Syndrome:

(show top 50)    (show all 560)
idTitleAuthorsYear
1
High or conventional positive end-expiratory pressure in adult respiratory distress syndrome. (24290732)
2013
2
An innovative approach to predict the development of adult respiratory distress syndrome in patients with blunt trauma. (22914080)
2012
3
The successful use of extra-corporeal membrane oxygenation in the management of a pregnant woman with severe H1N1 2009 influenza complicated by pneumonitis and adult respiratory distress syndrome. (20705450)
2010
4
The role of extracorporeal membrane oxygenation for treatment of the adult respiratory distress syndrome: review and quantitative analysis. (18361004)
2008
5
A systematic approach to care: adult respiratory distress syndrome. (18467944)
2008
6
High frequency oscillatory ventilation compared with conventional mechanical ventilation in adult respiratory distress syndrome: a randomized controlled trial [ISRCTN24242669]. (16137357)
2005
7
Absence of association between angiotensin converting enzyme polymorphism and development of adult respiratory distress syndrome in patients with severe acute respiratory syndrome: a case control study. (15819995)
2005
8
Massive rise in thyroglobulin with adult respiratory distress syndrome after embolisation of thyroid cancer metastasis. (10884754)
2000
9
Actin-containing sera from patients with adult respiratory distress syndrome are toxic to sheep pulmonary endothelial cells. (10903256)
2000
10
The adult respiratory distress syndrome after dextran infusion as an antithrombotic agent in free TRAM flap breast reconstruction. (10323708)
1999
11
Inhaled nitric oxide for adult respiratory distress syndrome after pulmonary resection. (9930465)
1998
12
High-frequency oscillatory ventilation for infants and children with adult respiratory distress syndrome. (9151467)
1997
13
A comparative study of the vasodilator effects of prostaglandin E1 in patients with pulmonary hypertension after mitral valve replacement and with adult respiratory distress syndrome. (9296401)
1997
14
Pulmonary actinomycosis: a cause of adult respiratory distress syndrome. (9200900)
1997
15
Alveolar macrophages of patients with adult respiratory distress syndrome express high levels of heat shock protein 72 mRNA. (8696981)
1996
16
Adult respiratory distress syndrome: learning lessons from the past. (8614895)
1996
17
Surfactant replacement therapy for adult respiratory distress syndrome in children. (8726159)
1996
18
Adult respiratory distress syndrome induced by a Chinese medicine, Kamisyoyo-san. (8835603)
1996
19
Pathogenesis and treatment of the adult respiratory distress syndrome. (8526694)
1996
20
The fibroproliferative phase of late adult respiratory distress syndrome. (7481129)
1995
21
Intracranial hypertension and adult respiratory distress syndrome: usefulness of tracheal gas insufflation. (7473982)
1995
22
Fibrosing alveolitis in the adult respiratory distress syndrome. (7985899)
1995
23
Effects of positive end-expiratory pressure on regional distribution of tidal volume and recruitment in adult respiratory distress syndrome. (7767524)
1995
24
Toxic epidermal necrolysis with adult respiratory distress syndrome. (7573872)
1995
25
Incidence of the adult respiratory distress syndrome in the state of Utah. (7663811)
1995
26
Adult respiratory distress syndrome in polymyositis patients with the anti-Jo-1 antibody. (7575703)
1995
27
Adult respiratory distress syndrome and late death following imipramine overdose: a case report. (7850687)
1994
28
Evaluation of definitions for adult respiratory distress syndrome. (8049808)
1994
29
Acute effects of a single dose of porcine surfactant on patients with the adult respiratory distress syndrome. (8031347)
1994
30
Oxidative damage to plasma proteins in adult respiratory distress syndrome. (8069386)
1994
31
Should inverse ratio ventilation be used in adult respiratory distress syndrome? (8173778)
1994
32
Endothelial cell harbingers of adult respiratory distress syndrome in acute pancreatitis. (7523814)
1994
33
Adult respiratory distress syndrome associated with amitriptyline overdose. (7975138)
1994
34
Ibuprofen overdose complicated by renal failure, adult respiratory distress syndrome, and metabolic acidosis. (8007040)
1994
35
Newer modes of mechanical ventilation for patients with adult respiratory distress syndrome. (8365232)
1993
36
Expression of tumor necrosis factor-alpha gene in alveolar macrophages from patients with the adult respiratory distress syndrome. (8503572)
1993
37
Respiratory mechanics and bronchodilator responsiveness in patients with the adult respiratory distress syndrome. (8420734)
1993
38
Adult respiratory distress syndrome. (8493185)
1993
39
Radiographic issues in adult respiratory distress syndrome. (8087568)
1993
40
Adult respiratory distress syndrome in children. (8385548)
1993
41
The case for and against fluid restriction and occlusion pressure reduction in adult respiratory distress syndrome. (8087569)
1993
42
Antioxidant activity of bronchoalveolar lavage fluid in the adult respiratory distress syndrome. (1539674)
1992
43
Oxidant stress and adult respiratory distress syndrome. (2278607)
1990
44
Changes in the fibrinolysin system in infantile and adult respiratory distress syndrome (ARDS), caused by trauma and/or septic shock in patients and in experimental animals. (2145377)
1990
45
Plasma tumor necrosis factor in patients with septic shock. Mortality rate, incidence of adult respiratory distress syndrome, and effects of methylprednisolone administration. (2297191)
1990
46
Miliary tuberculosis and adult respiratory distress syndrome. (3584648)
1987
47
Mycoplasmal pneumonia and adult respiratory distress syndrome: a complication to be recognized. (7241615)
1981
48
Miliary tuberculosis, with adult respiratory distress syndrome and a leukemoid reaction. (6765820)
1981
49
Adult respiratory distress syndrome one month following myocardial infarction: differential diagnosis, including particularly Dressler's syndrome. (6936642)
1981
50
The adult respiratory distress syndrome associated with miliary tuberculosis. (620556)
1978

Genetic Variations for Adult Respiratory Distress Syndrome

Expression for genes affiliated with Adult Respiratory Distress Syndrome

Sources:
1BioGPS, 15Gene Expression Omnibus DataSets
See all sources
Expression patterns in normal tissues for genes affiliated with Adult Respiratory Distress Syndrome

Search GEO for disease gene expression data for Adult Respiratory Distress Syndrome.

Pathways for genes affiliated with Adult Respiratory Distress Syndrome

Sources:
54Reactome, 38NCBI BioSystems Database, 12EMD Millipore, 30KEGG, 53R&D Systems, 52QIAGEN
See all sources

Pathways related to Adult Respiratory Distress Syndrome according to GeneCards/GeneDecks:

(show all 25)
idSuper pathways (with members indented)ScoreTop Affiliating Genes
110.3C5, C4A
2
Hide members
10.2ELN, ELANE
310.2SOD3, CAT
4
Cell adhesion ECM remodeling
Hide members
10.2ELN, FGA
510.1IL8, C5AR1, ELN
610.1IL8, CXCL1, CD14
7
Cytokine production by Th17 cells in CF (Mouse model)
10.1CD14, CXCL1, IL8
810.1C4A, C5AR1, C5
9
Immune response Lectin induced complement pathway
Hide members
10.1C5, C5AR1, C4A
1010.1CAT, SOD3, TNF
1110.1TNF, CD14, IL1R1
1210.1TNF, CD14, IL1R1
13
Hide members
10.1TNF, CXCL1, IL8
14
Hide members
10.0TNF, CD14, IL1R1, IL8
15
Immune response Bacterial infections in normal airways
Hide members
10.0IL8, IL1R1, CD14, TNF
1610.0IL8, IL1R1, CD14, TNF
17
Hide members
10.0ANGPT2, CD14, CXCL1, PLA2G6
18
Hide members
10.0C4A, FGA, C5AR1, C5
199.9TNF, CD14, CXCL1, IL8
20
Development PDGF signaling via STATs and NF-kB
Hide members
9.9TNF, ANGPT2, CD14, CXCL1
219.9C5, IL8, CD14, C4A, TNF
22
Hide members
9.8TNF, CD14, IL1R1, IL8, CP
239.8PLA2G6, IL8, IL1R1, CXCL1, TNF
249.8TNF, CD14, CXCL1, IL1R1, IL8
25
Hide members
9.7TNF, ANGPT2, CXCL1, IL1R1, IL8, PLA2G6

Compounds for genes affiliated with Adult Respiratory Distress Syndrome

Sources:
45Novoseek, 11DrugBank, 29IUPHAR, 60Tocris Bioscience, 50PharmGKB, 24HMDB, 2BitterDB
See all sources

Compounds related to Adult Respiratory Distress Syndrome according to GeneCards/GeneDecks:

(show top 50)    (show all 156)
idCompoundScoreTop Affiliating Genes
1pge24510.8ADRB2
2alpha tocopherol4510.5PLA2G6, ELANE
3endotoxin4510.5C4A, FGA, CXCL1
4cycloheximide4510.5CAT, PLA2G6, ELN
5pentoxifylline45 1111.5CD14, IL1R1, ELANE
6gm-csf45 2911.4CD14, TNF
7gold sodium thiomalate4510.4IL8, IL1R1, CD14, TNF
8cuprophan4510.3CD14, FGA, IL1R1, ELANE
9polysulfone4510.3CD14, FGA, IL1R1, ELANE
10anaphylatoxin4510.3C4A, IL8, C5AR1, C5, ELANE
11indomethacin45 60 29 1113.3IL1R1, PLA2G6, ELN
12dexamethasone45 50 29 1113.3ANGPT2, CD14, CXCL1, IL1R1, PLA2G6
13cellulose acetate4510.2ELANE, C5AR1, IL1R1, FGA
14cyclosporin a45 29 6012.2ANGPT2, CD14, CXCL1, IL1R1, ELANE
15neopterin4510.2TNF, CD14, IL1R1, IL8, ELANE
16txb24510.2C4A, CD14, FGA, PLA2G6, C5AR1
17protamine4510.2CP, FGA
18lipoteichoic acid4510.2TNF, CD14, IL1R1, IL8
19sulfasalazine45 29 50 1113.2TNF, CXCL1, IL1R1, IL8
20vitamin d4510.1SOD3, CD14, IL1R1, C5AR1, ELANE, ELN
21rolipram45 60 2912.1ELANE, ADRB2
22fluticasone propionate45 50 60 1113.1ELANE, ADRB2, IL8, TNF
23sodium nitroprusside4510.1CAT, SOD3, CP, ELANE, ELN
24norepinephrine45 11 2412.1ELANE
25superoxide45 2411.1SOD3, TNF, CXCL1, C5AR1, CP, ELANE
26aspirin45 50 29 2413.1FGA, IL1R1, PLA2G6, BCHE, ADRB2, ELANE
27leukotriene b445 60 2412.1TNF, CXCL1, IL1R1, IL8, C5AR1, ELANE
28hydrocortisone45 2 60 1113.1TNF, CD14, IL1R1, IL8, PLA2G6, ELANE
29rantes4510.0TNF, CD14, CXCL1, IL1R1, C5AR1
30fmlp4510.0TNF, CD14, CXCL1, IL8, C5AR1, ELANE
31h2o24510.0CAT, ANGPT2, IL1R1, C5AR1, BCHE, CP
32epinephrine45 11 2411.9FGA, CXCL1, IL1R1, ADRB2, CP, ELANE
33n acetylcysteine459.9CAT, SOD3, TNF, IL1R1, IL8, ELN
34actinomycin d459.9CAT, TNF, CXCL1, IL1R1, IL8, PLA2G6
35sb 20358045 6010.9CAT, TNF, CXCL1, IL1R1, IL8, PLA2G6
36oxygen45 2410.8SOD3, TNF, C4A, ANGPT2, IL8, C5AR1
37fibrinogen459.7TNF, ANGPT2, CD14, FGA, IL1R1, C5AR1
38histamine45 29 2411.7TNF, CD14, FGA, CXCL1, IL8, PLA2G6
39adenylate459.7SOD3, CXCL1, IL1R1, PLA2G6, ADRB2, CP
40nitric oxide45 11 2411.7CAT, SOD3, TNF, ANGPT2, CXCL1, IL1R1
41retinoic acid45 2410.6TNF, ANGPT2, CD14, CXCL1, IL1R1, PLA2G6
42arginine459.6SOD3, C4A, CD14, IL1R1, PLA2G6, C5AR1
43creatinine459.6ANGPT2, CD14, FGA, IL1R1, PLA2G6, C5AR1
44lactate459.5CAT, TNF, CD14, FGA, IL1R1, IL8
45serine459.5ELN, ADRB2, BCHE, C5AR1, PLA2G6, IL8
46lipid459.5CAT, SOD3, TNF, CD14, FGA, IL1R1
47vegf459.5SOD3, TNF, ANGPT2, CD14, CXCL1, IL1R1
48alanine459.4SOD3, CD14, IL1R1, C5AR1, BCHE, ADRB2
49heparin45 29 11 2412.4CP, BCHE, C5AR1, PLA2G6, IL8, IL1R1
50cysteine459.3CXCL1, CD14, ANGPT2, SOD3, CAT, IL1R1

GO Terms for genes affiliated with Adult Respiratory Distress Syndrome

Sources:
16Gene Ontology
See all sources

Cellular components related to Adult Respiratory Distress Syndrome according to GeneCards/GeneDecks:

idNameGO IDScoreTop Affiliating Genes
1cell surfaceGO:0099869.7CD14, FGA, IL1R1, C5AR1, ELANE, TNF
2extracellular spaceGO:0056158.8SOD3, TNF, C4A, ANGPT2, CD14, FGA
3extracellular regionGO:0055768.7ELN, TNF, C4A, ANGPT2, CD14, FGA

Biological processes related to Adult Respiratory Distress Syndrome according to GeneCards/GeneDecks:

idNameGO IDScoreTop Affiliating Genes
1activation of MAPK activityGO:00018710.0C5, C5AR1, TNF
2response to hypoxiaGO:00166610.0CAT, SOD3, TNF, ANGPT2
3chemotaxisGO:00693510.0C5, C5AR1, PLA2G6, CXCL1
4positive regulation of interleukin-8 biosynthetic processGO:0454169.9ELANE, TNF
5cell surface receptor signaling pathwayGO:0071669.9CD14, IL1R1, C5, ADRB2
6inflammatory responseGO:0069549.6C5, TNF, C4A, CD14, CXCL1, IL8

Molecular functions related to Adult Respiratory Distress Syndrome according to GeneCards/GeneDecks:

idNameGO IDScoreTop Affiliating Genes
1protease bindingGO:00202010.1ELANE, IL1R1, TNF
2chemokine activityGO:0080099.8CXCL1, IL8, C5
3receptor bindingGO:0051029.7C5, CXCL1, FGA, ANGPT2, CAT

Products for genes affiliated with Adult Respiratory Distress Syndrome

  • Antibodies
  • Proteins
  • Lysates
  • Antibodies

Sources for Adult Respiratory Distress Syndrome

3CDC
13ExPASy
14FMA
22GTR
23HGMD
24HMDB
25ICD10
26ICD10 via Orphanet
27ICD9CM
29IUPHAR
30KEGG
35MeSH
36MESH via Orphanet
37MGI
40NCIt
41NDF-RT
44NINDS
45Novoseek
47OMIM
48OMIM via Orphanet
51PubMed
52QIAGEN
58SNOMED-CT via Orphanet
61UMLS
62UMLS via Orphanet