ADULT SYNDROME
MCID: ADL002
MIFTS: 52

Adult Syndrome (ADULT SYNDROME) malady

Categories: Genetic diseases, Rare diseases, Eye diseases, Bone diseases, Skin diseases, Fetal diseases, Oral diseases

Aliases & Classifications for Adult Syndrome

Aliases & Descriptions for Adult Syndrome:

Name: Adult Syndrome 54 12 50 24 56 66 29 13 52 14 69
Acro-Dermato-Ungual-Lacrimal-Tooth Syndrome 12 50 24 56 66
Acro Dermato Ungual Lacrimal Tooth Syndrome 50 29
Pigment Anomaly-Ectrodactyly-Hypodontia Syndrome 56

Characteristics:

Orphanet epidemiological data:

56
adult syndrome
Inheritance: Autosomal dominant; Prevalence: <1/1000000 (Worldwide); Age of onset: Childhood;

HPO:

32
adult syndrome:
Inheritance autosomal dominant inheritance


Classifications:



External Ids:

OMIM 54 103285
Disease Ontology 12 DOID:0050601
Orphanet 56 ORPHA978
MESH via Orphanet 43 C538052
UMLS via Orphanet 70 C1863204
ICD10 via Orphanet 34 Q87.2
MedGen 40 C1863204
MeSH 42 D004476
ICD10 33 M83.9

Summaries for Adult Syndrome

UniProtKB/Swiss-Prot : 66 Acro-dermato-ungual-lacrimal-tooth syndrome: A form of ectodermal dysplasia. Ectodermal dysplasia defines a heterogeneous group of disorders due to abnormal development of two or more ectodermal structures. ADULT syndrome involves ectrodactyly, syndactyly, finger- and toenail dysplasia, hypoplastic breasts and nipples, intensive freckling, lacrimal duct atresia, frontal alopecia, primary hypodontia and loss of permanent teeth. ADULT syndrome differs significantly from EEC3 syndrome by the absence of facial clefting.

MalaCards based summary : Adult Syndrome, also known as acro-dermato-ungual-lacrimal-tooth syndrome, is related to ectodermal dysplasia and hypomyelinating leukodystrophy 13, and has symptoms including dry skin, finger syndactyly and wide nasal bridge. An important gene associated with Adult Syndrome is TP63 (Tumor Protein P63), and among its related pathways/superpathways is Insulin Pathway. The drugs Iloprost and Moxonidine have been mentioned in the context of this disorder. Affiliated tissues include breast, skin and bone, and related phenotype is embryo.

Disease Ontology : 12 An autosomal dominant disease that is characterized by light pigmentation with excessive freckling, sparse hair involving the scalp and axilla, lacrimal duct stenosis or atresia, onychodysplasia, hypodontia or early loss of permanent teeth, athelia or hypoplastic nipples, and breast hypoplasia, has material basis in a mutation in TP63.

Wikipedia : 71 Acro–dermato–ungual–lacrimal–tooth (ADULT) syndrome is a rare genetic disease. ADULT syndrome is... more...

Description from OMIM: 103285

Related Diseases for Adult Syndrome

Graphical network of the top 20 diseases related to Adult Syndrome:



Diseases related to Adult Syndrome

Symptoms & Phenotypes for Adult Syndrome

Symptoms by clinical synopsis from OMIM:

103285

Clinical features from OMIM:

103285

Human phenotypes related to Adult Syndrome:

56 32 (show all 40)
id Description HPO Frequency Orphanet Frequency HPO Source Accession
1 dry skin 56 32 Very frequent (99-80%) HP:0000958
2 finger syndactyly 56 32 Very frequent (99-80%) HP:0006101
3 wide nasal bridge 56 32 Occasional (29-5%) HP:0000431
4 thin skin 56 32 Very frequent (99-80%) HP:0000963
5 melanocytic nevus 56 32 Very frequent (99-80%) HP:0000995
6 skin ulcer 56 32 Very frequent (99-80%) HP:0200042
7 prominent nasal bridge 56 32 Occasional (29-5%) HP:0000426
8 sparse scalp hair 56 32 Frequent (79-30%) HP:0002209
9 fine hair 56 32 Very frequent (99-80%) HP:0002213
10 alopecia 56 32 Frequent (79-30%) HP:0001596
11 abnormality of dental morphology 56 32 Frequent (79-30%) HP:0006482
12 nasolacrimal duct obstruction 56 32 Very frequent (99-80%) HP:0000579
13 toe syndactyly 56 32 Very frequent (99-80%) HP:0001770
14 hypoplastic nipples 56 32 Frequent (79-30%) HP:0002557
15 fingernail dysplasia 56 32 Very frequent (99-80%) HP:0100798
16 nail pits 56 32 Very frequent (99-80%) HP:0001803
17 freckling 56 32 Very frequent (99-80%) HP:0001480
18 breast hypoplasia 56 32 Frequent (79-30%) HP:0003187
19 split foot 56 32 Very frequent (99-80%) HP:0001839
20 toenail dysplasia 56 32 Very frequent (99-80%) HP:0100797
21 absent nipple 56 32 Frequent (79-30%) HP:0002561
22 abnormality of the teeth 56 Very frequent (99-80%)
23 abnormality of the nail 56 Very frequent (99-80%)
24 microdontia 32 HP:0000691
25 wide intermamillary distance 32 HP:0006610
26 abnormality of the face 56 Occasional (29-5%)
27 conjunctivitis 32 HP:0000509
28 split hand 32 HP:0001171
29 eczema 32 HP:0000964
30 hypodontia 32 HP:0000668
31 cutaneous photosensitivity 32 HP:0000992
32 oral cleft 32 HP:0000202
33 oligodontia 32 HP:0000677
34 sparse axillary hair 32 HP:0002215
35 ectodermal dysplasia 32 HP:0000968
36 alopecia of scalp 32 HP:0002293
37 dermal atrophy 32 HP:0004334
38 fair hair 32 HP:0002286
39 adermatoglyphia 32 HP:0007455
40 premature loss of permanent teeth 32 HP:0006357

UMLS symptoms related to Adult Syndrome:


dry skin

MGI Mouse Phenotypes related to Adult Syndrome:

44
id Description MGI Source Accession Score Top Affiliating Genes
1 embryo MP:0005380 9.1 GRB10 IGF2 INS PHLDA2 SATB2 TP63

Drugs & Therapeutics for Adult Syndrome

Drugs for Adult Syndrome (from DrugBank, HMDB, Dgidb, PharmGKB, IUPHAR, NovoSeek, BitterDB):

(show top 50) (show all 1328)
id Name Status Phase Clinical Trials Cas Number PubChem Id
1
Iloprost Approved, Investigational Phase 4,Phase 3,Phase 2 78919-13-8 6443959
2 Moxonidine Approved Phase 4 75438-57-2 4810
3
Clonidine Approved Phase 4,Phase 2,Phase 1 4205-90-7 2803
4
Morphine Approved, Investigational Phase 4,Phase 3,Phase 2,Phase 1 57-27-2 5288826
5
Metformin Approved Phase 4,Phase 3,Phase 2,Phase 1,Early Phase 1 657-24-9 14219 4091
6
Midazolam Approved, Illicit Phase 4,Phase 1 59467-70-8 4192
7
Propofol Approved, Investigational, Vet_approved Phase 4 2078-54-8 4943
8
Remifentanil Approved Phase 4,Early Phase 1 132875-61-7 60815
9
Cyproterone Acetate Approved, Investigational Phase 4,Phase 2,Phase 3,Early Phase 1 427-51-0
10
Estradiol Approved, Investigational, Vet_approved Phase 4,Phase 3,Phase 2,Phase 1,Early Phase 1 50-28-2 5757 53477783
11
Ethinyl Estradiol Approved Phase 4,Phase 3,Phase 2,Phase 1,Early Phase 1 57-63-6 5991
12
Sodium oxybate Approved Phase 4 502-85-2 5360545
13
Orlistat Approved, Investigational Phase 4,Phase 2,Phase 1 96829-58-2 3034010
14
Epinephrine Approved, Vet_approved Phase 4,Phase 3,Phase 2,Phase 1 51-43-4 5816
15
Hydrocortisone Approved, Vet_approved Phase 4,Phase 3,Phase 2,Phase 1 50-23-7 5754 657311
16
Lamivudine Approved, Investigational Phase 4,Phase 3,Phase 2,Phase 1 134678-17-4 60825
17
Stavudine Approved, Investigational Phase 4 3056-17-5 18283
18
Pentoxifylline Approved, Investigational Phase 4,Phase 3,Phase 1 6493-05-6 4740
19
Ezetimibe Approved Phase 4,Phase 3 163222-33-1 150311
20
Simvastatin Approved Phase 4,Phase 3,Phase 2 79902-63-9 54454
21
Colchicine Approved Phase 4,Phase 3,Phase 2,Phase 1 64-86-8 6167 2833
22
Cyclosporine Approved, Investigational, Vet_approved Phase 4,Phase 3,Phase 2,Phase 1,Early Phase 1 79217-60-0, 59865-13-3 5284373 6435893
23
Methylprednisolone Approved, Vet_approved Phase 4,Phase 2,Phase 3,Phase 1 83-43-2 6741
24
Mycophenolate mofetil Approved, Investigational Phase 4,Phase 3,Phase 1,Phase 2 128794-94-5 5281078
25
Mycophenolic acid Approved Phase 4,Phase 3,Phase 1,Phase 2 24280-93-1 446541
26
Prednisolone Approved, Vet_approved Phase 4,Phase 2,Phase 3,Phase 1 50-24-8 5755
27
Azacitidine Approved, Investigational Phase 4,Phase 2,Phase 3,Phase 1 320-67-2 9444
28
Decitabine Approved, Investigational Phase 4,Phase 2,Phase 3,Phase 1 2353-33-5 451668
29
Acetaminophen Approved Phase 4,Phase 3,Phase 2 103-90-2 1983
30
Prednisone Approved, Vet_approved Phase 4,Phase 3,Phase 2,Phase 1 53-03-2 5865
31
Pioglitazone Approved, Investigational Phase 4,Phase 3,Phase 2,Phase 1,Early Phase 1 111025-46-8 4829
32
lanreotide Approved Phase 4,Phase 3,Phase 2 108736-35-2
33
Somatostatin Approved Phase 4,Phase 3,Phase 2 38916-34-6, 51110-01-1 53481605
34
Ranolazine Approved, Investigational Phase 4,Phase 3,Phase 2 142387-99-3, 95635-55-5 56959
35
Acetylcholine Approved Phase 4,Phase 2,Phase 3,Phase 1,Early Phase 1 51-84-3 187
36
Calcium carbonate Approved Phase 4,Phase 3,Phase 1,Phase 2 471-34-1
37
Cyclophosphamide Approved, Investigational Phase 4,Phase 3,Phase 2,Phase 1,Early Phase 1 50-18-0, 6055-19-2 2907
38
Miconazole Approved, Investigational, Vet_approved Phase 4,Phase 3,Phase 2,Phase 1,Early Phase 1 22916-47-8 4189
39
Citalopram Approved Phase 4,Phase 3,Phase 2,Phase 1 59729-33-8 2771
40
Benzocaine Approved Phase 4,Phase 2,Phase 3,Phase 1,Early Phase 1 1994-09-7, 94-09-7 2337
41
Dopamine Approved Phase 4,Phase 3,Phase 2,Phase 1,Early Phase 1 51-61-6, 62-31-7 681
42
Varenicline Approved, Investigational Phase 4,Phase 3 249296-44-4 5310966
43
Gabapentin Approved, Investigational Phase 4,Phase 3,Phase 2 60142-96-3 3446
44
Ramipril Approved Phase 4,Phase 3,Phase 1 87333-19-5 5362129
45
Telmisartan Approved, Investigational Phase 4,Phase 3 144701-48-4 65999
46
Metyrapone Approved Phase 4,Phase 3 54-36-4 4174
47
Montelukast Approved Phase 4 158966-92-8 5281040
48
Ticagrelor Approved Phase 4,Phase 3,Phase 2,Phase 1 274693-27-5 9871419
49
Memantine Approved, Investigational Phase 4,Phase 2 19982-08-2 4054
50
Pregabalin Approved, Illicit, Investigational Phase 4,Phase 3,Phase 2 148553-50-8 5486971

Interventional clinical trials:

(show top 50) (show all 5000)
id Name Status NCT ID Phase
1 Effect of Vitamin D on Metabolic Parameters in Patients With the Metabolic Syndrome Unknown status NCT01237769 Phase 4
2 Effects of Iloprost Treatment in Adult Patients With Pulmonary Arterial Hypertension Related to Congenital Heart Disease Unknown status NCT01383083 Phase 4
3 Study of the Effect of Moxonidine and Diet on Sympathetic Functions in Young Adults With Obesity Unknown status NCT01180231 Phase 4
4 Vitamin D and Inflammatory Cytokine Levels After Acute Myocardial Infraction (MI) Unknown status NCT01115842 Phase 4
5 NAS Treatment - Opiate Versus Non-Opiate Unknown status NCT01734551 Phase 4
6 Effects of Neuromuscular Blocking Agents (NMBA) on the Alteration of Transpulmonary Pressures at the Early Phase of Acute Respiratory Distress Syndrome (ARDS) Unknown status NCT01573715 Phase 4
7 Effect of Growth Hormone in Metabolic Syndrome Unknown status NCT00307411 Phase 4
8 Trial of Supplementation With Aged Garlic Extract to Improve Endothelial Function in Patients With Metabolic Syndrome Unknown status NCT01168700 Phase 4
9 Therapeutic Monitoring of Metformin in Women With Polycystic Ovary Syndrome Unknown status NCT01366391 Phase 4
10 Saccharomyces Boulardii in Diarrhea Dominant Irritable Bowel Syndrome Unknown status NCT00543478 Phase 4
11 Melatonin Versus Placebo in the Lennox-Gastaut Syndrome: Neurophysiological and Neuropsychological Effects Unknown status NCT01370486 Phase 4
12 Metformin in Postmenopausal Women With Metabolic Syndrome Unknown status NCT01342744 Phase 4
13 Propofol Versus Midazolam as Premedication for Preterm Neonates With Respiratory Distress Syndrome (RDS) Unknown status NCT00797160 Phase 4
14 the Effect of Diane-35 Pretreatment on In-vitro Fertilization Outcome for Patients With Polycystic Ovary Syndrome Unknown status NCT01752270 Phase 4
15 Surgical Ovarian Drilling Versus Hormonal Treatment for Infertility Associated to PolyCystic Ovaries Syndrome (PCOS) Unknown status NCT00378729 Phase 4
16 Sodium Oxybate in Patients With Chronic Fatigue Syndrome. Unknown status NCT01584934 Phase 4
17 The Effect of Weight Loss on Anti-Müllerian Hormone Levels in Women With Polycystic Ovary Syndrome (PCOS) Unknown status NCT01475019 Phase 4
18 Effect of Treatment With Stress-Doses Glucocorticoid in Patients With Acute Respiratory Distress Syndrome (ARDS) Unknown status NCT00773058 Phase 4
19 Study on the Antiviral Therapy and Immune Reconstitution of Chinese HIV/AIDS Patients Unknown status NCT00872417 Phase 4
20 Effect of Pentoxifylline on Tight Junctions (TJs) of Intestinal Mucosa in Patients With Irritable Bowel Syndrome(IBS) Unknown status NCT01542268 Phase 4
21 Use of Sildenafil (Viagra) to Alter Fatigue, Functional Status and Impaired Cerebral Blood Flow in Patients With CFS Unknown status NCT00598585 Phase 4
22 Effects of Ezetimibe, Simvastatin, and Vytorin on Reducing L5 a Subfraction of LDL in Patients With Metabolic Syndrome. Unknown status NCT00988364 Phase 4
23 Colchicine for Acute Coronary Syndromes Unknown status NCT01906749 Phase 4
24 Effects of the Ivabradine on Reduction of Inflammatory Markers in Patients With Acute Coronary Syndrome Unknown status NCT00815100 Phase 4
25 Efficacy Evaluation of Surfactant Administration Via Laryngeal Mask Airway Unknown status NCT01173237 Phase 4
26 Study of 7-valent Pneumococcal Conjugate Vaccine in Children With Idiopathic Nephrotic Syndrome Unknown status NCT01346007 Phase 4
27 A Phase Ⅳ Study of Decitabine in Myelodysplastic Syndrome Unknown status NCT02013102 Phase 4
28 Close Kinect Chain Exercise With Kinesio Taping in the Management of Patellofemoral Pain Syndrome Unknown status NCT02241148 Phase 4
29 Mycophenolate Mofetil in Pediatric Steroid Dependent Nephrotic Syndrome Unknown status NCT01895894 Phase 4
30 Low Dose Steroids in the Treatment of Nephrotic Syndrome Relapse Unknown status NCT02216747 Phase 4
31 Continuous Positive Airway Pressure in Sleep Apnea Syndrome: Effects on Metabolic Syndrome and Cardiac Damage Unknown status NCT00517777 Phase 4
32 6-Methyl-Prednisolone for Multiple Organ Dysfunction Syndrome Unknown status NCT00127985 Phase 4
33 Sex Steroids in Sjögren's Syndrome: Effect of Substitution Treatment on Fatigue Unknown status NCT00543166 Phase 4
34 Early CPAP in Respiratory Distress Syndrome Unknown status NCT00368680 Phase 4
35 The Effect of a Diet Based on Low Sodium and Slowly Absorbed Carbohydrates on the Incidence of Refeeding Syndrome in Patients With Head and Neck Cancer Unknown status NCT01845922 Phase 4
36 Fixed-dose vs. Phenotype-based PrAsugrel Dose to MATCH Therapeutic Zone in Asians With Acute Coronary Syndrome Unknown status NCT01951001 Phase 4
37 Pioglitazone Vs Placebo in Combination With Niacin Extended Release on Low HDL Unknown status NCT00300365 Phase 4
38 Treatment of the Dumping Syndrome With Lanreotide Autogel® Unknown status NCT00543179 Phase 4
39 Ranolazine, Ethnicity and the Metabolic Syndrome Unknown status NCT01304095 Phase 4
40 Botulinum A Toxin in the Treatment of Patients With Painful Bladder Syndrome Unknown status NCT01157507 Phase 4
41 The ACT-OUT Trial: ACTivity OUTcomes Based on High Carbohydrate or High Fat Diet in Metabolic Syndrome Unknown status NCT01357382 Phase 4
42 Comparison of the Efficacy and Safety of Tiropramide and Octylonium in the Treatment of Irritable Bowel Syndrome Unknown status NCT01629212 Phase 4
43 Strategies for Ovulation Induction in Anovulatory Infertile Patients With PCOS Unknown status NCT00461643 Phase 4
44 Cyclosporine A in the TReatment of Interstitial Pneumonitis Associated With Sjogren's Syndrome Unknown status NCT02370550 Phase 4
45 Study of Escitalopram Versus Placebo in the Treatment of Depressive Syndrome in Alzheimer’s Disease, Vascular Dementia, and Mixed Vascular and Alzheimer’s Dementia Unknown status NCT00229333 Phase 4
46 A Placebo Controlled Double Masked Clinical Assessment Study of Essential Fatty Acid Supplement and Its Effect on Patients With Apparent Aqueous Deficient Dry Eye Syndrome Unknown status NCT00344721 Phase 4
47 Effect of Rotigotine Patch Treatment on Cardiovascular Markers in Idiopathic Restless Legs Syndrome Unknown status NCT01823770 Phase 4
48 Endometrial Scratching During Laproscopic Ovarian Drilling in Subfertile PCOS Women Unknown status NCT02140398 Phase 4
49 Safety and Efficacy of the Novel Selective Nicotinic Receptor Partial Agonist, CHANTIX (Varenicline) in Patients With Acute Coronary Syndrome Unknown status NCT01170338 Phase 4
50 Effects of Gabapentin Enacarbil on Arousals, Heart Rate, Blood Pressure and PLMs in Restless Legs Syndrome Unknown status NCT02424695 Phase 4

Search NIH Clinical Center for Adult Syndrome

Genetic Tests for Adult Syndrome

Genetic tests related to Adult Syndrome:

id Genetic test Affiliating Genes
1 Adult Syndrome 29 24 TP63
2 Acro-Dermato-Ungual-Lacrimal-Tooth (adult) Syndrome 29

Anatomical Context for Adult Syndrome

MalaCards organs/tissues related to Adult Syndrome:

39
Breast, Skin, Bone, Eye

Publications for Adult Syndrome

Articles related to Adult Syndrome:

(show all 20)
id Title Authors Year
1
Intermediate Phenotype between ADULT Syndrome and EEC Syndrome Caused by R243Q Mutation in TP63. ( 28293528 )
2016
2
Shaken adult syndrome: report of 2 cases. ( 24077385 )
2013
3
ADULT syndrome due to an R243W mutation in TP63. ( 22607287 )
2012
4
Functional characterization of a novel TP63 mutation in a family with overlapping features of Rapp-Hodgkin/AEC/ADULT syndromes. ( 22069181 )
2011
5
Cleft palate and ADULT phenotype in a patient with a novel TP63 mutation suggests lumping of EEC/LM/ADULT syndromes into a unique entity: ELA syndrome. ( 21990121 )
2011
6
Adermatoglyphia, previously unrecognized manifestation in ADULT syndrome. ( 20814947 )
2010
7
ADULT syndrome caused by a mutation previously associated with EEC syndrome. ( 21078104 )
2010
8
A novel TP63 mutation in family with ADULT syndrome presenting with eczema and hypothelia. ( 19530185 )
2009
9
Mutation analysis of p63 gene in the first Chinese family with ADULT syndrome. ( 19781362 )
2009
10
Severe persistent nasolacrimal duct obstruction: a typical finding in ADULT syndrome. ( 16929068 )
2006
11
Delineation of the ADULT syndrome phenotype due to arginine 298 mutations of the p63 gene. ( 16724007 )
2006
12
Further phenotypic and genetic variation in ADULT syndrome. ( 17041931 )
2006
13
Acro-dermato-ungual-lacrimal-tooth (ADULT) syndrome: report of a child with phenotypic overlap with ulnar-mammary syndrome and a new mutation in TP63. ( 16114047 )
2005
14
Shaken adult syndrome revisited. ( 12960674 )
2003
15
Gain-of-function mutation in ADULT syndrome reveals the presence of a second transactivation domain in p63. ( 11929852 )
2002
16
TP63 gene mutation in ADULT syndrome. ( 11528512 )
2001
17
Domestic violence: the shaken adult syndrome. ( 10718242 )
2000
18
ADULT syndrome allelic to limb mammary syndrome (LMS)? ( 10607963 )
2000
19
Shaken adult syndrome. ( 9430280 )
1997
20
ADULT-syndrome: an autosomal-dominant disorder with pigment anomalies, ectrodactyly, nail dysplasia, and hypodontia. ( 8456838 )
1993

Variations for Adult Syndrome

UniProtKB/Swiss-Prot genetic disease variations for Adult Syndrome:

66
id Symbol AA change Variation ID SNP ID
1 TP63 p.Arg337Gln VAR_020875 rs113993967

ClinVar genetic disease variations for Adult Syndrome:

6
id Gene Variation Type Significance SNP ID Assembly Location
1 TP63 NM_001114982.1(TP63): c.16A> C (p.Asn6His) single nucleotide variant Pathogenic rs113993963 GRCh37 Chromosome 3, 189507605: 189507605
2 TP63 NM_003722.4(TP63): c.1010G> A (p.Arg337Gln) single nucleotide variant Pathogenic rs113993967 GRCh37 Chromosome 3, 189586386: 189586386
3 TP63 TP63, VAL114MET single nucleotide variant Pathogenic
4 TP63 NM_003722.4(TP63): c.1054A> G (p.Arg352Gly) single nucleotide variant Pathogenic rs121908847 GRCh37 Chromosome 3, 189586430: 189586430
5 TP63 NM_003722.4(TP63): c.1009C> G (p.Arg337Gly) single nucleotide variant Pathogenic rs113993966 GRCh37 Chromosome 3, 189586385: 189586385
6 TP63 NM_003722.4(TP63): c.797G> A (p.Arg266Gln) single nucleotide variant Pathogenic rs121908849 GRCh37 Chromosome 3, 189584501: 189584501
7 TP63 TP63, PRO127LEU single nucleotide variant Pathogenic
8 TP63 NM_003722.4(TP63): c.1846delC (p.Leu616Serfs) deletion Pathogenic rs113993964 GRCh37 Chromosome 3, 189612094: 189612094
9 TP63 NM_003722.4(TP63): c.518G> A (p.Gly173Asp) single nucleotide variant Pathogenic rs113993965 GRCh37 Chromosome 3, 189526254: 189526254
10 TP63 NM_003722.4(TP63): c.1963delC (p.Arg655Glufs) deletion Pathogenic rs797044843 GRCh37 Chromosome 3, 189612211: 189612211

Expression for Adult Syndrome

Search GEO for disease gene expression data for Adult Syndrome.

Pathways for Adult Syndrome

Pathways related to Adult Syndrome according to GeneCards Suite gene sharing:

id Super pathways Score Top Affiliating Genes
1 10.26 GRB10 INS

GO Terms for Adult Syndrome

Biological processes related to Adult Syndrome according to GeneCards Suite gene sharing:

id Name GO ID Score Top Affiliating Genes
1 positive regulation of mitotic nuclear division GO:0045840 9.16 IGF2 INS
2 positive regulation of glycogen biosynthetic process GO:0045725 8.96 IGF2 INS
3 positive regulation of insulin receptor signaling pathway GO:0046628 8.62 IGF2 INS

Molecular functions related to Adult Syndrome according to GeneCards Suite gene sharing:

id Name GO ID Score Top Affiliating Genes
1 insulin-like growth factor receptor binding GO:0005159 8.96 IGF2 INS
2 insulin receptor binding GO:0005158 8.8 GRB10 IGF2 INS

Sources for Adult Syndrome

3 CDC
7 CNVD
9 Cosmic
10 dbSNP
11 DGIdb
16 ExPASy
18 FMA
28 GO
29 GTR
30 HGMD
31 HMDB
32 HPO
33 ICD10
34 ICD10 via Orphanet
35 ICD9CM
36 IUPHAR
37 KEGG
38 LifeMap
40 MedGen
42 MeSH
43 MESH via Orphanet
44 MGI
46 NCI
47 NCIt
48 NDF-RT
51 NINDS
52 Novoseek
54 OMIM
55 OMIM via Orphanet
59 PubMed
60 QIAGEN
65 SNOMED-CT via Orphanet
67 TGDB
68 Tocris
69 UMLS
70 UMLS via Orphanet
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