ATLL
MCID: ADL017
MIFTS: 46

Adult T-Cell Leukemia (ATLL) malady

Cancer diseases, Skin diseases, Blood diseases, Rare diseases, Immune diseases categories

Summaries for Adult T-Cell Leukemia

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9Disease Ontology, 34MalaCards
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Disease Ontology:9 A t-cell leukemia that results in abnormal increase of lymphocytes, derives from t-cells, has material basis in human t-lymphotropic virus 1, which is transmitted by sexual contact, transmitted by contaminated needles used by intravenous-drug users, and transmitted by breast feeding. the infection results in formation of skin lesions.

MalaCards: Adult T-Cell Leukemia, also known as adult t-cell leukemia/lymphoma, is related to t-cell leukemia and mycosis fungoides. An important gene associated with Adult T-Cell Leukemia is PMAIP1 (phorbol-12-myristate-13-acetate-induced protein 1), and among its related pathways are Hematopoietic cell lineage and ERK Signaling. The compounds leptomycin b and ccl4 have been mentioned in the context of this disorder. Affiliated tissues include t cells, skin and breast.

Aliases & Classifications for Adult T-Cell Leukemia

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Sources:
9Disease Ontology, 11DISEASES, 32LifeMap Discoveryā„¢, 50Orphanet, 46Novoseek, 63UMLS, 37MESH via Orphanet, 27ICD10 via Orphanet, 60SNOMED-CT via Orphanet, 64UMLS via Orphanet, 26ICD10
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Classifications:



Characteristics (Orphanet epidemiological data):

50
adult t-cell leukemia/lymphoma:
Age of onset: Adulthood


Aliases & Descriptions:

adult t-cell leukemia 9 11 32
adult t-cell leukemia/lymphoma 9 50
t cell leukemia lymphoma adult 46
adult t-cell lymphoma/leukemia 63
atll 50


External Ids:

Disease Ontology9 DOID:0050523
MESH via Orphanet37 D015459
ICD10 via Orphanet27 C91.5
SNOMED-CT via Orphanet60 110007008, 188729005, 77430005
UMLS via Orphanet64 C0023493
ICD1026 C91.5

Related Diseases for Adult T-Cell Leukemia

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Sources:
18GeneCards, 19GeneDecks
See all sources

Diseases in the Acute T Cell Leukemia family:

adult t-cell leukemia T-Cell Leukemia
Human T-Cell Leukemia Virus Type 1 Human T-Cell Leukemia Virus Type 2
Human T-Cell Leukemia Virus Type 3 Leukemia, B-Cell, Chronic
Leukemia, T-Cell, Chronic

Diseases related to Adult T-Cell Leukemia via text searches within MalaCards or GeneCards/GeneDecks gene sharing:

(show top 50)    (show all 95)
idRelated DiseaseScoreTop Affiliating Genes
1t-cell leukemia32.2CD7, CNTN2, HTLVR, CCR4, PTHLH
2mycosis fungoides30.8CCR4, CD7
3rheumatoid arthritis30.1CCR4, HTLVR, CNTN2, CD7
4leukemia11.6
5hematopoietic stem cell transplantation10.8
6human t-cell leukemia virus type 110.8
7hypercalcemia10.7
8tropical spastic paraparesis10.7
9spastic paraparesis10.7
10spasticity10.7
11scabies10.6
12pneumonia10.5
13peripheral t-cell lymphoma10.5
14endotheliitis10.5
15strongyloidiasis10.5
16cutaneous t cell lymphoma10.5
17dermatitis10.5
18graft versus host disease10.4
19acute pancreatitis10.4
20follicular mucinosis10.4
21norwegian scabies10.4
22eosinophilia10.4
23hepatitis10.4
24meningitis10.4
25pancreatitis10.4
26retinitis10.4
27acute liver failure10.3
28acute myeloid leukemia10.3
29pancytopenia10.3
30anaplastic large cell lymphoma10.3
31herpes simplex10.3
32hodgkin's lymphoma10.3
33myeloid leukemia10.3
34neuropathy10.3
35b-cell lymphomas10.3
36diffuse panbronchiolitis10.3
37chronic actinic dermatitis10.3
38dyshidrosis10.2
39neuronitis10.2
40hepatitis b10.2
41ulcerative colitis10.2
42infectious mononucleosis10.2
43herpes zoster10.2
44hypersplenism10.2
45duodenitis10.2
46epidermodysplasia verruciformis10.2
47retinal vasculitis10.2
48acute leukemia10.2
49retinal ischemia10.2
50tracheal stenosis10.2

Graphical network of the top 20 diseases related to Adult T-Cell Leukemia:



Diseases related to adult t-cell leukemia

Symptoms for Adult T-Cell Leukemia

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Drugs & Therapeutics for Adult T-Cell Leukemia

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Sources:
6CenterWatch, 43NIH Clinical Center, 7ClinicalTrials, 32LifeMap Discoveryā„¢, 63UMLS, 42NDF-RT
See all sources

Approved drugs:

Search CenterWatch for Adult T-Cell Leukemia

Drug clinical trials:

Search ClinicalTrials for Adult T-Cell Leukemia

Search NIH Clinical Center for Adult T-Cell Leukemia

Search CenterWatch for Adult T-Cell Leukemia

Cell-based therapeutics:


LifeMap Discovery
The database of embryonic development, stem cell research and regenerative medicine
Read about Adult T-Cell Leukemia cell therapies at LifeMap Discovery.
Stem-cell-based therapeutic approaches for Adult T-Cell Leukemia:
Hematopoietic stem cells for treatment of hematologic malignancies
Embryonic/Adult Cultured Cells Related to Adult T-Cell Leukemia:
Bone marrow-derived hematopoietic stem cells

Genetic Tests for Adult T-Cell Leukemia

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Anatomical Context for Adult T-Cell Leukemia

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Sources:
34MalaCards
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MalaCards organs/tissues related to Adult T-Cell Leukemia:

34
T cells, Skin, Breast, Bone, Lung, Liver, Endothelial, B cells, Bone marrow, Colon, Retina, Myeloid, Monocytes, Lymph node, Thyroid, Thymus, Testis

Animal Models for Adult T-Cell Leukemia or affiliated genes

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Publications for Adult T-Cell Leukemia

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Sources:
53PubMed
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Articles related to Adult T-Cell Leukemia:

(show top 50)    (show all 700)
idTitleAuthorsYear
1
Stevens-Johnson Syndrome associated with mogamulizumab treatment of adult T-cell leukemia / lymphoma. (23360455)
2013
2
CD4 and CD8 double-negative adult T-cell leukemia/lymphoma with monomorphic cells expressing CD99: a diagnostic challenge in a country non-endemic for human T-cell leukemia virus. (23464972)
2013
3
Strong effect of mogamulizumab on splenic residual disease of adult T cell leukemia/lymphoma. (23949316)
2013
4
Autologous Tax-specific CTL therapy in a primary adult T cell leukemia/lymphoma cell-bearing NOD/Shi-scid, IL-2RI^null mouse model. (23733874)
2013
5
Variant human T-cell lymphotropic virus type 1c and adult T-cell leukemia, Australia. (24047544)
2013
6
Mogamulizumab for the treatment of adult T-cell leukemia/lymphoma. (23110261)
2012
7
Increase in incidence of adult T-cell leukemia/lymphoma in non-endemic areas of Japan and the United States. (22738276)
2012
8
Targeting Bcl-2 family proteins in adult T-cell leukemia/lymphoma: in vitro and in vivo effects of the novel Bcl-2 family inhibitor ABT-737. (22138435)
2012
9
Granulomatous reaction at the site of healed herpes zoster in a patient with adult T-cell leukemia/lymphoma. (21950342)
2012
10
Honokiol induces cell cycle arrest and apoptosis via inhibition of survival signals in adult T-cell leukemia. (22465179)
2012
11
Interleukin-2 receptor targeted therapy of ocular disease of HTLV-1-associated adult T-cell leukemia. (22642512)
2012
12
Anti-adult T-cell leukemia effects of Bidens pilosa. (21318218)
2011
13
Adult T-cell leukemia/lymphoma with CLL-like morphology. (21461296)
2011
14
FERM domain mutations induce gain of function in JAK3 in adult T-cell leukemia/lymphoma. (21821710)
2011
15
Clinical and laboratory features in adult T-cell leukemia/lymphoma in Khorasan, Iran. (20178409)
2010
16
Retraction. Tanji H, Ishikawa C, Sawada S, Nakachi S, Takamatsu R, Matsuda T, Okudaira T, Uchihara J-N, Ohshiro K, Tanaka Y, Senba M, Uezato H, Ohshima K, Duc Dodon M, Wu K-J, Mori N. Aberrant expression of the transcription factor Twist in adult T-cell leukemia [published online ahead of print January 13, 2010]. Blood. doi:10.1182/blood-2009-07-232231. (20574045)
2010
17
Absence of gain-of-function JAK1 and JAK3 mutations in adult T cell leukemia/lymphoma. (20697856)
2010
18
Osteolytic bone resorption in adult T-cell leukemia/lymphoma. (20214446)
2010
19
Trends in HTLV-1 prevalence and incidence of adult T-cell leukemia/lymphoma in Nagasaki, Japan. (20166187)
2010
20
PD-1/PD-L1 expression in human T-cell leukemia virus type 1 carriers and adult T-cell leukemia/lymphoma patients. (18830259)
2009
21
The International Prognostic Index predicts outcome in aggressive adult T-cell leukemia/lymphoma: analysis of 126 patients from the International Peripheral T-Cell Lymphoma Project. (19150954)
2009
22
Rearranged NF-kappa B2 gene in an adult T-cell leukemia cell line. (18377428)
2008
23
Case of adult T-cell leukemia with pulmonary involvement presenting as nodular shadows. (18419680)
2008
24
Activation of complement system in adult T-cell leukemia (ATL) occurs mainly through lectin pathway: a serum proteomic approach using mass spectrometry. (18691810)
2008
25
A network biology approach evaluating the anticancer effects of bortezomib identifies SPARC as a therapeutic target in adult T-cell leukemia cells. (21918608)
2008
26
Clinical efficacy of all-trans retinoic acid for treating adult T cell leukemia. (18008086)
2008
27
Splenectomy for hypersplenism caused by adult T-cell leukemia: report of a case. (19039645)
2008
28
Stem cell properties and the side population cells as a target for interferon-alpha in adult T-cell leukemia/lymphoma. (17977513)
2007
29
Inactivation of p14ARF as a key event for the progression of adult T cell leukemia/lymphoma. (18246599)
2007
30
Mature T-cell leukemias including T-prolymphocytic leukemia, adult T-cell leukemia/lymphoma, and SAczary syndrome. (17369126)
2007
31
Implication of the HTLV-I bZIP factor gene in the leukemogenesis of adult T-cell leukemia. (17875522)
2007
32
Blocking NF-kappaB as a potential strategy to treat adult T-cell leukemia/lymphoma. (16823495)
2006
33
Survey of chemokine receptor expression reveals frequent co-expression of skin-homing CCR4 and CCR10 in adult T-cell leukemia/lymphoma. (17071491)
2006
34
Transcriptional regulation of parathyroid hormone-related protein promoter P3 by ETS-1 in adult T-cell leukemia/lymphoma. (15889157)
2005
35
Identification of two new HLA-A*1101-restricted tax epitopes recognized by cytotoxic T lymphocytes in an adult T-cell leukemia patient after hematopoietic stem cell transplantation. (16014972)
2005
36
Natural history of adult T-cell leukemia/lymphoma and approaches to therapy. (16155611)
2005
37
IL-2-regulated persistent human herpesvirus-6B infection facilitates growth of adult T cell leukemia cells. (16187619)
2005
38
Potential immunogenicity of adult T cell leukemia cells in vivo. (15551352)
2005
39
Reduced expression of human mismatch repair genes in adult T-cell leukemia. (15682421)
2005
40
Tax-independent constitutive IkappaB kinase activation in adult T-cell leukemia cells. (15153339)
2004
41
Role of HTLV-1 proviral DNA load and clonality in the development of adult T-cell leukemia/lymphoma in asymptomatic carriers. (15122598)
2004
42
Hemophagocytic syndrome as a presenting sign of transformation of smoldering to acute adult T-cell leukemia/lymphoma: efficacy of anti-retroviral and interferon therapy. (15164389)
2004
43
Deoxycoformycin-containing combination chemotherapy for adult T-cell leukemia-lymphoma: Japan Clinical Oncology Group Study (JCOG9109). (12627852)
2003
44
Multiple osteolysis of peripheral extremities in a patient with adult T cell leukemia/lymphoma. (10526948)
1999
45
OX40 expressed on fresh leukemic cells from adult T-cell leukemia patients mediates cell adhesion to vascular endothelial cells: implication for the possible involvement of OX40 in leukemic cell infiltration. (9108415)
1997
46
Increased expression of human thioredoxin/adult T cell leukemia-derived factor in SjAPgren's syndrome. (8639174)
1996
47
Prevalence of human T-cell leukemia virus type 1 (HTLV-I) in family members of adult T-cell leukemia (ATL) patients in non-ATL-endemic Hokkaido of Japan. (7669948)
1995
48
Adhesion properties of adult T cell leukemia cells. (7787750)
1995
49
Mitochondrial induction of adult T cell leukemia derived factor (ADF/hTx) after oxidative stresses in retinal pigment epithelial cells. (8206709)
1994
50
Reactive oxygen-reducing and protein-refolding activities of adult T cell leukemia-derived factor/human thioredoxin. (1510657)
1992

Variations for Adult T-Cell Leukemia

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Expression for genes affiliated with Adult T-Cell Leukemia

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Sources:
2BioGPS, 16Gene Expression Omnibus DataSets
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Expression patterns in normal tissues for genes affiliated with Adult T-Cell Leukemia

Search GEO for disease gene expression data for Adult T-Cell Leukemia.

Pathways for genes affiliated with Adult T-Cell Leukemia

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51PathCards, 31KEGG, 54QIAGEN
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Pathways related to Adult T-Cell Leukemia according to GeneCards/GeneDecks:

idSuper pathways (with members indented)ScoreTop Affiliating Genes
19.7CD7, IL9R
2
Show member pathways
9.0IL9R, CCR4, PMAIP1, SPOCK3

Compounds for genes affiliated with Adult T-Cell Leukemia

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46Novoseek, 62Tocris Bioscience, 30IUPHAR
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Compounds related to Adult T-Cell Leukemia according to GeneCards/GeneDecks:

idCompoundScoreTop Affiliating Genes
1leptomycin b46 6210.6CNTN2, PTHLH
2ccl446 3010.6CCR4, PTHLH

GO Terms for genes affiliated with Adult T-Cell Leukemia

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Products for genes affiliated with Adult T-Cell Leukemia

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  • Antibodies
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  • Antibodies

Sources for Adult T-Cell Leukemia

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4CDC
14ExPASy
15FMA
23GTR
24HGMD
25HMDB
26ICD10
27ICD10 via Orphanet
28ICD9CM
30IUPHAR
31KEGG
36MeSH
37MESH via Orphanet
38MGI
41NCIt
42NDF-RT
45NINDS
46Novoseek
48OMIM
49OMIM via Orphanet
53PubMed
54QIAGEN
60SNOMED-CT via Orphanet
63UMLS
64UMLS via Orphanet