ATLL
MCID: ADL017
MIFTS: 53

Adult T-Cell Leukemia (ATLL) malady

Cancer diseases, Skin diseases, Blood diseases, Immune diseases categories

Summaries for Adult T-Cell Leukemia

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8Disease Ontology, 32MalaCards
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Disease Ontology:8 A t-cell leukemia that results in abnormal increase of lymphocytes, derives from t-cells, has material basis in human t-lymphotropic virus 1, which is transmitted by sexual contact, transmitted by contaminated needles used by intravenous-drug users, and transmitted by breast feeding. the infection results in formation of skin lesions.

MalaCards: Adult T-Cell Leukemia, also known as adult t-cell leukemia/lymphoma, is related to t-cell leukemia and leukemia. An important gene associated with Adult T-Cell Leukemia is PMAIP1 (phorbol-12-myristate-13-acetate-induced protein 1), and among its related pathways are Rho Family GTPases and PEDF Induced Signaling. The compounds ccl4 and [alcl] have been mentioned in the context of this disorder. Affiliated tissues include t cells, skin and breast.

Aliases & Classifications for Adult T-Cell Leukemia

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Sources:
8Disease Ontology, 10DISEASES, 44Novoseek, 48Orphanet, 30LifeMap Discovery™, 60UMLS, 35MESH via Orphanet, 26ICD10 via Orphanet, 57SNOMED-CT via Orphanet, 61UMLS via Orphanet, 25ICD10
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Classifications:

Malacards categories (disease lists): (See all malacards categories)
Global: Cancer diseases
Anatomical: Skin diseases, Blood diseases, Immune diseases


Characteristics (Orphanet epidemiological data):

48
adult t-cell leukemia/lymphoma:
Age of onset: Adulthood


Aliases & Descriptions:

adult t-cell leukemia 8 10 30
adult t-cell leukemia/lymphoma 8 48
t cell leukemia lymphoma adult 44
adult t-cell lymphoma/leukemia 60
atll 48


External Ids:

Disease Ontology8 DOID:0050523
MESH via Orphanet35 D015459
ICD10 via Orphanet26 C91.5
SNOMED-CT via Orphanet57 110007008, 188729005, 77430005
UMLS via Orphanet61 C0023493
ICD1025 C91.5

Related Diseases for Adult T-Cell Leukemia

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Sources:
17GeneCards, 18GeneDecks
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Diseases in the Acute T Cell Leukemia family:

adult t-cell leukemia T-Cell Leukemia
Leukemia, B-Cell, Chronic Leukemia, T-Cell, Chronic
Human T-Cell Leukemia Virus Type 1 Human T-Cell Leukemia Virus Type 2
Human T-Cell Leukemia Virus Type 3

Diseases related to Adult T-Cell Leukemia via text searches within MalaCards or GeneCards/GeneDecks gene sharing:

(show top 50)    (show all 105)
idRelated DiseaseScoreTop Affiliating Genes
1t-cell leukemia32.3TXN, CCR4, TNFRSF8, HTLVR, CNTN2, CD7
2leukemia32.3TCL1A, HTLVR, CNTN2, CD7
3cutaneous t cell lymphoma31.1CCR4, CCR10, TNFRSF8
4mycosis fungoides30.7CCL22, CCR4, CCR10, TNFRSF8, CD7
5dermatitis30.7CCR10, CCR4, CCL22
6hodgkin's lymphoma30.4CCL22, CCR4, TNFRSF8, TCL1A
7rheumatoid arthritis30.2TXN, CCR4, TNFRSF8, HTLVR, CNTN2, CD7
8arthritis30.2TXN
9hepatitis b30.2MAGEA4, TNFRSF8, TXN
10severe combined immunodeficiency30.2TNFRSF8
11adult lymphoma11.4
12acute t cell leukemia10.9
13acute leukemia10.9
14hypercalcemia10.7
15tropical spastic paraparesis10.7
16adult syndrome10.6
17bone lymphoma10.5
18scabies10.5
19pneumonia10.5
20strongyloidiasis10.4
21central nervous system leukemia10.4
22t cell deficiency10.4
23graft versus host disease10.4
24lymphoid leukemia10.4
25norwegian scabies10.4
26acute pancreatitis10.4
27follicular mucinosis10.4
28anaplastic large cell lymphoma10.4
29eosinophilia10.4
30hepatitis10.4
31meningitis10.4
32myeloid leukemia10.4
33pancreatitis10.4
34retinitis10.4
35acute liver failure10.3
36colon lymphoma10.3
37central nervous system lymphoma10.3
38acute myeloid leukemia10.3
39pancytopenia10.3
40herpes simplex10.3
41monocytic leukemia10.3
42neuropathy10.3
43non-hodgkin lymphoma10.3
44erythema multiforme10.3
45papillary carcinoma10.3
46papillary thyroid carcinoma10.3
47paranasal sinus lymphoma10.1
48retinal ischemia10.1
49tracheal stenosis10.1
50thyroid lymphoma10.1

Graphical network of the top 20 diseases related to Adult T-Cell Leukemia:



Diseases related to adult t-cell leukemia

Clinical Features for Adult T-Cell Leukemia

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Drugs & Therapeutics for Adult T-Cell Leukemia

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Sources:
5CenterWatch, 41NIH Clinical Center, 6ClinicalTrials, 30LifeMap Discovery™, 60UMLS, 40NDF-RT
See all sources

Approved drugs:

Search CenterWatch for Adult T-Cell Leukemia

Drug clinical trials:

Search ClinicalTrials for Adult T-Cell Leukemia

Search NIH Clinical Center for Adult T-Cell Leukemia

Search CenterWatch for Adult T-Cell Leukemia

Cell-based therapeutics:


LifeMap Discovery
The database of embryonic development, stem cell research and regenerative medicine
Read about Adult T-Cell Leukemia cell therapies at LifeMap Discovery.
Stem-cell-based therapeutic approaches for Adult T-Cell Leukemia:
Hematopoietic stem cells for treatment of hematologic malignancies
Embryonic/Adult Cultured Cells Related to Adult T-Cell Leukemia:
Bone marrow-derived hematopoietic stem cells

Genetic Tests for Adult T-Cell Leukemia

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Anatomical Context for Adult T-Cell Leukemia

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Sources:
32MalaCards
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MalaCards organs/tissues related to Adult T-Cell Leukemia:

32
T cells, Skin, Breast, Bone, Lung, B cells, Endothelial, Liver, Myeloid, Bone marrow, Colon, Monocytes, Thyroid, Retina, Lymph node, Testis, Thymus

Animal Models for Adult T-Cell Leukemia or affiliated genes

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Publications for Adult T-Cell Leukemia

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Sources:
50PubMed
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Articles related to Adult T-Cell Leukemia:

(show top 50)    (show all 744)
idTitleAuthorsYear
1
Combination of skin-directed therapy and oral etoposide for smoldering adult T-cell leukemia/lymphoma with skin involvement. (22830614)
2013
2
Adult T-cell leukemia/lymphoma with an unusual CD1a positive phenotype. (24000197)
2013
3
Development of a novel redirected T-cell-based adoptive immunotherapy targeting human telomerase reverse transcriptase for adult T-cell leukemia. (23641014)
2013
4
Granulomatous reaction at the site of healed herpes zoster in a patient with adult T-cell leukemia/lymphoma. (21950342)
2012
5
Impact of graft-versus-host disease on outcomes after allogeneic hematopoietic cell transplantation for adult T-cell leukemia: a retrospective cohort study. (22234682)
2012
6
Adult T-cell leukemia/lymphoma with CLL-like morphology. (21461296)
2011
7
Senescence induction therapy for the treatment of adult T-cell leukemia. (21067445)
2011
8
ATF3, an HTLV-1 bZip factor binding protein, promotes proliferation of adult T-cell leukemia cells. (21414204)
2011
9
Azacitidine induces demethylation of p16INK4a and inhibits growth in adult T-cell leukemia/lymphoma. (21785817)
2011
10
Aberrant overexpression of membrane-associated mucin contributes to tumor progression in adult T-cell leukemia/lymphoma cells. (21599593)
2011
11
Interferon alfa and antiretroviral agents: a treatment option for adult T-cell leukemia/lymphoma. (21850284)
2011
12
Adult T-cell leukemia in India: report of two cases and review of literature. (22044818)
2011
13
Absence of gain-of-function JAK1 and JAK3 mutations in adult T cell leukemia/lymphoma. (20697856)
2010
14
Challenging the adult T-cell leukemia/lymphoma (ATL) stem cell concept based on limiting dilution transplantation assay. (20223932)
2010
15
AZ960, a novel Jak2 inhibitor, induces growth arrest and apoptosis in adult T-cell leukemia cells. (21159615)
2010
16
Current management of adult T-cell leukemia/lymphoma. (20120837)
2009
17
Definition, prognostic factors, treatment, and response criteria of adult T-cell leukemia-lymphoma: a proposal from an international consensus meeting. (19064971)
2009
18
FoxP3+ regulatory T cells are distinct from leukemia cells in HTLV-1-associated adult T-cell leukemia. (19544530)
2009
19
Transformation of adult myelodysplastic syndrome-refractory anemia to acute T-cell lymphoblastic leukemia. (19397230)
2009
20
Rearranged NF-kappa B2 gene in an adult T-cell leukemia cell line. (18377428)
2008
21
Critical role for TSLC1 expression in the growth and organ infiltration of adult T-cell leukemia cells in vivo. (18922876)
2008
22
Adult T-cell leukemia/lymphoma: report of two cases. (18719810)
2008
23
Adult T cell leukemia: a typical case from India. (18626153)
2008
24
New entity, definition and diagnostic criteria of cutaneous adult T-cell leukemia/lymphoma: human T-lymphotropic virus type 1 proviral DNA load can distinguish between cutaneous and smoldering types. (18477226)
2008
25
Antibody to the central region of human T-lymphotropic virus type 1 gp46 is associated with the progression of adult T-cell leukemia. (17297657)
2007
26
Augmented expression of programmed death-1 in both neoplastic and non-neoplastic CD4+ T-cells in adult T-cell leukemia/lymphoma. (17721918)
2007
27
High incidence of Notch-1 mutations in adult patients with T-cell acute lymphoblastic leukemia. (16424867)
2006
28
Complete response in a patient with adult T-cell leukemia (ATL) treated with combination of alemtuzumab and pentostatin. (15979704)
2006
29
HTLV-I basic leucine zipper factor gene mRNA supports proliferation of adult T cell leukemia cells. (16407133)
2006
30
CD4/CD8 double-positive, acute type of adult T-cell leukemia/lymphoma with extensive cutaneous involvement. (17040438)
2006
31
Centrosome amplification in adult T-cell leukemia and human T-cell leukemia virus type 1 Tax-induced human T cells. (16805820)
2006
32
Adult T-cell leukemia presenting with acute liver failure. (16516291)
2006
33
IL-2-regulated persistent human herpesvirus-6B infection facilitates growth of adult T cell leukemia cells. (16187619)
2005
34
Adult T-cell leukemia: future prophylaxis and immunotherapy. (15161436)
2004
35
Activating Fc receptors are required for antitumor efficacy of the antibodies directed toward CD25 in a murine model of adult t-cell leukemia. (15313926)
2004
36
Aberrant expression of the MEL1S gene identified in association with hypomethylation in adult T-cell leukemia cells. (14656887)
2004
37
Mechanism of hypercalcemia in adult T-cell leukemia: overexpression of receptor activator of nuclear factor kappaB ligand on adult T-cell leukemia cells. (11781248)
2002
38
Minimal residual disease monitoring in adult T-cell acute lymphoblastic leukemia: a molecular based approach using T-cell receptor G and D gene rearrangements. (12414341)
2002
39
Frequent expression of CCR4 in adult T-cell leukemia and human T-cell leukemia virus type 1-transformed T cells. (11861261)
2002
40
Multiple gammac-receptor expression in adult T-cell leukemia. (12225394)
2002
41
Adult T-cell leukemia (ATL) cells which express neural cell adhesion molecule (NCAM) and infiltrate into the central nervous system. (11838588)
2002
42
Tumor necrosis factor alpha polymorphism associated with increased susceptibility to development of adult T-cell leukemia/lymphoma in human T-lymphotropic virus type 1 carriers. (11325850)
2001
43
Increasing methylation of the CDKN2A gene is associated with the progression of adult T-cell leukemia. (10706122)
2000
44
The methylthioadenosine phosphorylase gene is frequently co-deleted with the p16INK4a gene in acute type adult T-cell leukemia. (9426690)
1998
45
Features of the cytokines secreted by adult T cell leukemia (ATL) cells. (9172809)
1996
46
Characterization of a HTLV-I-infected cell line derived from a patient with adult T-cell leukemia with stable co-expression of CD4 and CD8. (7564472)
1995
47
Induction of ICAM-1 and LFA-3 by Tax1 of human T-cell leukemia virus type 1 and mechanism of down-regulation of ICAM-1 or LFA-1 in adult-T-cell-leukemia cell lines. (7530239)
1995
48
A patient with primary hypoparathyroidism developing hypercalcemia associated with adult T-cell leukemia/lymphoma. (7812215)
1994
49
Adult T-cell leukemia involving the central nervous system after remission of adult respiratory distress syndrome. (8252991)
1993
50
Altered expression of protein kinase C in adult T-cell leukemia cells. (1421175)
1992

Genetic Variations for Adult T-Cell Leukemia

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Expression for genes affiliated with Adult T-Cell Leukemia

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Sources:
1BioGPS, 15Gene Expression Omnibus DataSets
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Expression patterns in normal tissues for genes affiliated with Adult T-Cell Leukemia

Search GEO for disease gene expression data for Adult T-Cell Leukemia.

Pathways for genes affiliated with Adult T-Cell Leukemia

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51QIAGEN, 29KEGG, 53Reactome
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Compounds for genes affiliated with Adult T-Cell Leukemia

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44Novoseek, 28IUPHAR, 59Tocris Bioscience
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Compounds related to Adult T-Cell Leukemia according to GeneCards/GeneDecks:

idCompoundScoreTop Affiliating Genes
1ccl444 2811.7PTHLH, CCR4, CCL22
2[alcl]4410.6TNFRSF8, CCR4
3larc4410.5CCR4, CCL22
4cyclosporin a44 28 5912.4TXN, CCL22, TNFRSF8, CNTN2

GO Terms for genes affiliated with Adult T-Cell Leukemia

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16Gene Ontology
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Biological processes related to Adult T-Cell Leukemia according to GeneCards/GeneDecks:

idNameGO IDScoreTop Affiliating Genes
1immune responseGO:00695510.7CD7, CCR10, CCR4, CCL22
2chemotaxisGO:00693510.4CCR10, CCR4, CCL22

Molecular functions related to Adult T-Cell Leukemia according to GeneCards/GeneDecks:

idNameGO IDScoreTop Affiliating Genes
1C-C chemokine receptor activityGO:01649310.6CCR10, CCR4

Products for genes affiliated with Adult T-Cell Leukemia

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  • Antibodies

Sources for Adult T-Cell Leukemia

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3CDC
13ExPASy
14FMA
22GTR
23HGMD
24HMDB
25ICD10
26ICD10 via Orphanet
27ICD9CM
28IUPHAR
29KEGG
34MeSH
35MESH via Orphanet
36MGI
39NCIt
40NDF-RT
43NINDS
44Novoseek
46OMIM
47OMIM via Orphanet
50PubMed
51QIAGEN
57SNOMED-CT via Orphanet
60UMLS
61UMLS via Orphanet