MCID: ADL017
MIFTS: 40

Adult T-Cell Leukemia malady

Cancer diseases, Skin diseases, Blood diseases, Rare diseases, Immune diseases categories

Summaries for Adult T-Cell Leukemia

About this section


Disease Ontology:9 A t-cell leukemia that results in abnormal increase of lymphocytes, derives from t-cells, has material basis in human t-lymphotropic virus 1, which is transmitted by sexual contact, transmitted by contaminated needles used by intravenous-drug users, and transmitted by breast feeding. the infection results in formation of skin lesions.

MalaCards based summary: Adult T-Cell Leukemia, also known as adult t-cell leukemia/lymphoma, is related to t-cell leukemia and mycosis fungoides. An important gene associated with Adult T-Cell Leukemia is PMAIP1 (phorbol-12-myristate-13-acetate-induced protein 1), and among its related pathways are Hematopoietic cell lineage and ERK Signaling. The compounds leptomycin b and ccl4 have been mentioned in the context of this disorder. Affiliated tissues include t cells, skin and breast.

Aliases & Classifications for Adult T-Cell Leukemia

About this section
Sources:
30LifeMap Discovery®, 9Disease Ontology, 11DISEASES, 47Orphanet, 43Novoseek, 60UMLS, 38NCIt, 26ICD10 via Orphanet, 61UMLS via Orphanet, 34MESH via Orphanet, 25ICD10
See all sources

Adult T-Cell Leukemia, Aliases & Descriptions:

Name: Adult T-Cell Leukemia 30 9 11
Adult T-Cell Leukemia/lymphoma 9 47
T Cell Leukemia Lymphoma Adult 43
 
Adult T-Cell Lymphoma/leukemia 60
Leukemia, T-Cell 60
Atll 47


Classifications:



Characteristics (Orphanet epidemiological data):

47
adult t-cell leukemia/lymphoma:
Age of onset: Adult


External Ids:

Disease Ontology9 DOID:0050523
NCIt38 C3184
Orphanet47 86875
ICD10 via Orphanet26 C91.5
UMLS via Orphanet61 C0023493
MESH via Orphanet34 D015459
ICD1025 C91.5

Related Diseases for Adult T-Cell Leukemia

About this section

Diseases in the T-Cell Leukemia family:

adult t-cell leukemia Acute T Cell Leukemia
Human T-Cell Leukemia Virus Type 1 Human T-Cell Leukemia Virus Type 2
Human T-Cell Leukemia Virus Type 3 Leukemia, B-Cell, Chronic
Leukemia, T-Cell, Chronic

Diseases related to Adult T-Cell Leukemia via text searches within MalaCards or GeneCards Suite gene sharing:

(show top 50)    (show all 92)
idRelated DiseaseScoreTop Affiliating Genes
1t-cell leukemia31.5CD7, CNTN2, HTLVR, CCR4, PTHLH
2mycosis fungoides30.7CCR4, CD7
3rheumatoid arthritis29.7CCR4, HTLVR, CNTN2, CD7
4leukemia11.6
5hematopoietic stem cell transplantation10.8
6human t-cell leukemia virus type 110.8
7hypercalcemia10.7
8tropical spastic paraparesis10.7
9spastic paraparesis10.7
10spasticity10.7
11scabies10.5
12hepatitis10.5
13peripheral t-cell lymphoma10.5
14pneumonia10.5
15endotheliitis10.5
16strongyloidiasis10.5
17follicular mucinosis10.5
18cutaneous t cell lymphoma10.5
19hepatitis b10.4
20acute pancreatitis10.4
21norwegian scabies10.4
22dermatitis10.4
23eosinophilia10.4
24meningitis10.4
25pancreatitis10.4
26retinitis10.4
27acute liver failure10.3
28anaplastic large cell lymphoma10.3
29arthritis10.3
30b-cell lymphomas10.3
31pancytopenia10.3
32colitis10.3
33herpes simplex10.3
34myeloid leukemia10.3
35neuropathy10.3
36systemic lupus erythematosus10.2
37hepatocellular carcinoma10.2
38epidermodysplasia verruciformis10.2
39bacteremia10.2
40adenomatous polyposis coli10.2
41acute leukemia10.2
42adult respiratory distress syndrome10.2
43cataract10.2
44granuloma annulare10.2
45keloids10.2
46lymphoid leukemia10.2
47retinal ischemia10.2
48severe combined immunodeficiency10.2
49ulcerative colitis10.2
50dyshidrosis10.2

Graphical network of the top 20 diseases related to Adult T-Cell Leukemia:



Diseases related to adult t-cell leukemia

Symptoms for Adult T-Cell Leukemia

About this section

Drugs & Therapeutics for Adult T-Cell Leukemia

About this section

Drug clinical trials:

Search ClinicalTrials for Adult T-Cell Leukemia

Search NIH Clinical Center for Adult T-Cell Leukemia

Cell-based therapeutics:


LifeMap Discovery
Data from LifeMap, the Embryonic Development and Stem Cells Database
Read about Adult T-Cell Leukemia cell therapies at LifeMap Discovery.
Stem-cell-based therapeutic approaches for Adult T-Cell Leukemia:
Hematopoietic stem cells for treatment of hematologic malignancies
Embryonic/Adult Cultured Cells Related to Adult T-Cell Leukemia:
Bone marrow-derived hematopoietic stem cells

Genetic Tests for Adult T-Cell Leukemia

About this section

Anatomical Context for Adult T-Cell Leukemia

About this section

MalaCards organs/tissues related to Adult T-Cell Leukemia:

31
T cells, Skin, Breast, Bone, Lung, Liver, Endothelial, B cells, Bone marrow, Colon, Myeloid, Lymph node, Retina, Monocytes, Thymus, Thyroid, Testis, Neutrophil

Animal Models for Adult T-Cell Leukemia or affiliated genes

About this section

Publications for Adult T-Cell Leukemia

About this section

Articles related to Adult T-Cell Leukemia:

(show top 50)    (show all 745)
idTitleAuthorsYear
1
Incidence of adult T-cell leukemia/lymphoma in nonendemic areas. (25762122)
2015
2
HTLV-1-infected CD4+ T-cells display alternative exon usages that culminate in adult T-cell leukemia. (25519886)
2014
3
Involvement of double-stranded RNA-dependent protein kinase and antisense viral RNA in the constitutive NFI_B activation in adult T-cell leukemia/lymphoma cells. (25567137)
2014
4
Stevens-Johnson Syndrome associated with mogamulizumab treatment of adult T-cell leukemia / lymphoma. (23360455)
2013
5
CD4 and CD8 double-negative adult T-cell leukemia/lymphoma with monomorphic cells expressing CD99: a diagnostic challenge in a country non-endemic for human T-cell leukemia virus. (23464972)
2013
6
Strong effect of mogamulizumab on splenic residual disease of adult T cell leukemia/lymphoma. (23949316)
2013
7
Autologous Tax-specific CTL therapy in a primary adult T cell leukemia/lymphoma cell-bearing NOD/Shi-scid, IL-2RI^null mouse model. (23733874)
2013
8
Variant human T-cell lymphotropic virus type 1c and adult T-cell leukemia, Australia. (24047544)
2013
9
Mogamulizumab for the treatment of adult T-cell leukemia/lymphoma. (23110261)
2012
10
Increase in incidence of adult T-cell leukemia/lymphoma in non-endemic areas of Japan and the United States. (22738276)
2012
11
Targeting Bcl-2 family proteins in adult T-cell leukemia/lymphoma: in vitro and in vivo effects of the novel Bcl-2 family inhibitor ABT-737. (22138435)
2012
12
Granulomatous reaction at the site of healed herpes zoster in a patient with adult T-cell leukemia/lymphoma. (21950342)
2012
13
Honokiol induces cell cycle arrest and apoptosis via inhibition of survival signals in adult T-cell leukemia. (22465179)
2012
14
Anti-adult T-cell leukemia effects of Bidens pilosa. (21318218)
2011
15
Adult T-cell leukemia/lymphoma with CLL-like morphology. (21461296)
2011
16
FERM domain mutations induce gain of function in JAK3 in adult T-cell leukemia/lymphoma. (21821710)
2011
17
Clinical and laboratory features in adult T-cell leukemia/lymphoma in Khorasan, Iran. (20178409)
2010
18
Retraction. Tanji H, Ishikawa C, Sawada S, Nakachi S, Takamatsu R, Matsuda T, Okudaira T, Uchihara J-N, Ohshiro K, Tanaka Y, Senba M, Uezato H, Ohshima K, Duc Dodon M, Wu K-J, Mori N. Aberrant expression of the transcription factor Twist in adult T-cell leukemia [published online ahead of print January 13, 2010]. Blood. doi:10.1182/blood-2009-07-232231. (20574045)
2010
19
Absence of gain-of-function JAK1 and JAK3 mutations in adult T cell leukemia/lymphoma. (20697856)
2010
20
PD-1/PD-L1 expression in human T-cell leukemia virus type 1 carriers and adult T-cell leukemia/lymphoma patients. (18830259)
2009
21
The International Prognostic Index predicts outcome in aggressive adult T-cell leukemia/lymphoma: analysis of 126 patients from the International Peripheral T-Cell Lymphoma Project. (19150954)
2009
22
Cardiac involvement with human T-cell lymphotrophic virus type-1-associated adult T-cell leukemia/lymphoma: The NIH experience. (18297519)
2008
23
Rearranged NF-kappa B2 gene in an adult T-cell leukemia cell line. (18377428)
2008
24
Case of adult T-cell leukemia with pulmonary involvement presenting as nodular shadows. (18419680)
2008
25
Activation of complement system in adult T-cell leukemia (ATL) occurs mainly through lectin pathway: a serum proteomic approach using mass spectrometry. (18691810)
2008
26
A network biology approach evaluating the anticancer effects of bortezomib identifies SPARC as a therapeutic target in adult T-cell leukemia cells. (21918608)
2008
27
Clinical efficacy of all-trans retinoic acid for treating adult T cell leukemia. (18008086)
2008
28
Stem cell properties and the side population cells as a target for interferon-alpha in adult T-cell leukemia/lymphoma. (17977513)
2007
29
Inactivation of p14ARF as a key event for the progression of adult T cell leukemia/lymphoma. (18246599)
2007
30
Mature T-cell leukemias including T-prolymphocytic leukemia, adult T-cell leukemia/lymphoma, and SAczary syndrome. (17369126)
2007
31
Implication of the HTLV-I bZIP factor gene in the leukemogenesis of adult T-cell leukemia. (17875522)
2007
32
Blocking NF-kappaB as a potential strategy to treat adult T-cell leukemia/lymphoma. (16823495)
2006
33
Survey of chemokine receptor expression reveals frequent co-expression of skin-homing CCR4 and CCR10 in adult T-cell leukemia/lymphoma. (17071491)
2006
34
Transcriptional regulation of parathyroid hormone-related protein promoter P3 by ETS-1 in adult T-cell leukemia/lymphoma. (15889157)
2005
35
Identification of two new HLA-A*1101-restricted tax epitopes recognized by cytotoxic T lymphocytes in an adult T-cell leukemia patient after hematopoietic stem cell transplantation. (16014972)
2005
36
Natural history of adult T-cell leukemia/lymphoma and approaches to therapy. (16155611)
2005
37
IL-2-regulated persistent human herpesvirus-6B infection facilitates growth of adult T cell leukemia cells. (16187619)
2005
38
Potential immunogenicity of adult T cell leukemia cells in vivo. (15551352)
2005
39
Reduced expression of human mismatch repair genes in adult T-cell leukemia. (15682421)
2005
40
Tax-independent constitutive IkappaB kinase activation in adult T-cell leukemia cells. (15153339)
2004
41
Role of HTLV-1 proviral DNA load and clonality in the development of adult T-cell leukemia/lymphoma in asymptomatic carriers. (15122598)
2004
42
Hemophagocytic syndrome as a presenting sign of transformation of smoldering to acute adult T-cell leukemia/lymphoma: efficacy of anti-retroviral and interferon therapy. (15164389)
2004
43
Deoxycoformycin-containing combination chemotherapy for adult T-cell leukemia-lymphoma: Japan Clinical Oncology Group Study (JCOG9109). (12627852)
2003
44
Multiple osteolysis of peripheral extremities in a patient with adult T cell leukemia/lymphoma. (10526948)
1999
45
OX40 expressed on fresh leukemic cells from adult T-cell leukemia patients mediates cell adhesion to vascular endothelial cells: implication for the possible involvement of OX40 in leukemic cell infiltration. (9108415)
1997
46
Increased expression of human thioredoxin/adult T cell leukemia-derived factor in SjAPgren's syndrome. (8639174)
1996
47
Prevalence of human T-cell leukemia virus type 1 (HTLV-I) in family members of adult T-cell leukemia (ATL) patients in non-ATL-endemic Hokkaido of Japan. (7669948)
1995
48
Adhesion properties of adult T cell leukemia cells. (7787750)
1995
49
Mitochondrial induction of adult T cell leukemia derived factor (ADF/hTx) after oxidative stresses in retinal pigment epithelial cells. (8206709)
1994
50
Reactive oxygen-reducing and protein-refolding activities of adult T cell leukemia-derived factor/human thioredoxin. (1510657)
1992

Variations for Adult T-Cell Leukemia

About this section

Expression for genes affiliated with Adult T-Cell Leukemia

About this section
Search GEO for disease gene expression data for Adult T-Cell Leukemia.

Pathways for genes affiliated with Adult T-Cell Leukemia

About this section

Pathways related to Adult T-Cell Leukemia according to GeneCards Suite gene sharing:

idSuper pathways (with members indented)ScoreTop Affiliating Genes
19.7CD7, IL9R
2
Show member pathways
9.0IL9R, CCR4, PMAIP1, SPOCK3

Compounds for genes affiliated with Adult T-Cell Leukemia

About this section
Sources:
43Novoseek, 59Tocris Bioscience, 28IUPHAR
See all sources

Compounds related to Adult T-Cell Leukemia according to GeneCards Suite gene sharing:

idCompoundScoreTop Affiliating Genes
1leptomycin b43 5910.6CNTN2, PTHLH
2ccl443 2810.6CCR4, PTHLH

GO Terms for genes affiliated with Adult T-Cell Leukemia

About this section

Products for genes affiliated with Adult T-Cell Leukemia

About this section
  • Antibodies
  • Proteins
  • Lysates
  • Antibodies
  • Proteins
  • Kits and Assays

Sources for Adult T-Cell Leukemia

About this section
3CDC
13ExPASy
14FMA
22GTR
23HGMD
24HMDB
25ICD10
26ICD10 via Orphanet
27ICD9CM
28IUPHAR
29KEGG
33MeSH
34MESH via Orphanet
35MGI
38NCIt
39NDF-RT
42NINDS
43Novoseek
45OMIM
46OMIM via Orphanet
50PubMed
51QIAGEN
56SNOMED-CT via Orphanet
60UMLS
61UMLS via Orphanet