ATLL
MCID: ADL017
MIFTS: 60

Adult T-Cell Leukemia (ATLL) malady

Categories: Rare diseases, Cancer diseases, Skin diseases, Blood diseases, Immune diseases

Aliases & Classifications for Adult T-Cell Leukemia

Aliases & Descriptions for Adult T-Cell Leukemia:

Name: Adult T-Cell Leukemia 38 12 14
Adult T-Cell Leukemia/lymphoma 12 50 56
Atll 50 56
Adult T-Cell Leukaemia/lymphoma 50
Leukemia-Lymphoma, Adult T-Cell 42
T Cell Leukemia Lymphoma Adult 52
Adult T-Cell Lymphoma/leukemia 69
Adult T-Cell Leukaemia 50
Adult T-Cell Lymphoma 50
Leukemia, T-Cell 69

Characteristics:

Orphanet epidemiological data:

56
adult t-cell leukemia/lymphoma
Inheritance: Multigenic/multifactorial,Not applicable; Age of onset: Adult;

Classifications:



External Ids:

Disease Ontology 12 DOID:0050523
ICD10 33 C91.5 C91.50
MeSH 42 D015459
NCIt 47 C3184
Orphanet 56 ORPHA86875
MESH via Orphanet 43 D015459
UMLS via Orphanet 70 C0023493
ICD10 via Orphanet 34 C91.5
UMLS 69 C0023493

Summaries for Adult T-Cell Leukemia

NIH Rare Diseases : 50 adult t-cell leukemia/lymphoma (atl) is is a rare and aggressive t-cell lymphoma that is linked to infection by the human t-cell lymphotropic virus 1 (htlv-1). the exact mechanism by which htlv-i infection causes the atl is unknown. the clinical features of atl include generalized swelling of the lymph nodes (lymphadenopathy), increased liver and spleen size (hepatosplenomegaly), immunosuppression, high levels of calcium in the blood, lytic bone lesions (spots that appear as “holes” on a standard bone x-ray), and skin lesions.  there are four basic clinical variants of atl: acute (60% of cases), lymphomatous (20 % of cases), chronic (10% of cases) and smoldering (10% of cases). the best treatment for these patients is unclear and patients should be enrolled in clinical trials whenever possible. medication may include chop (cyclophosphamide, doxorubicin, vincristine and prednisone) or epoch (etoposide, vincristine, doxorubicin, cyclophosphamide and prednisone). in some patients, a bone marrow transplant may be recommended. last updated: 9/13/2016

MalaCards based summary : Adult T-Cell Leukemia, also known as adult t-cell leukemia/lymphoma, is related to human t-cell leukemia virus type 1 and tropical spastic paraparesis. An important gene associated with Adult T-Cell Leukemia is PMAIP1 (Phorbol-12-Myristate-13-Acetate-Induced Protein 1), and among its related pathways/superpathways are ERK Signaling and TNFR1 Pathway. The drugs Asparaginase and Cyclophosphamide have been mentioned in the context of this disorder. Affiliated tissues include t cells, skin and bone, and related phenotypes are Synthetic lethal with MLN4924 (a NAE inhibitor) and endocrine/exocrine gland

Disease Ontology : 12 A T-cell leukemia that results_in abnormal increase of lymphocytes, derives from T-cells, has material basis in Human T-lymphotropic virus 1, which is transmitted_by sexual contact, transmitted_by contaminated needles used by intravenous-drug users, and transmitted_by breast feeding. The infection results_in_formation_of skin lesions.

Related Diseases for Adult T-Cell Leukemia

Diseases in the T-Cell Leukemia family:

Adult T-Cell Leukemia Acute T Cell Leukemia
Human T-Cell Leukemia Virus Type 1 Human T-Cell Leukemia Virus Type 2
Human T-Cell Leukemia Virus Type 3 Leukemia, B-Cell, Chronic
Leukemia, T-Cell, Chronic

Diseases related to Adult T-Cell Leukemia via text searches within MalaCards or GeneCards Suite gene sharing:

(show top 50) (show all 124)
id Related Disease Score Top Affiliating Genes
1 human t-cell leukemia virus type 1 11.4
2 tropical spastic paraparesis 11.4
3 precursor t-cell acute lymphoblastic leukemia 11.3
4 leukemia, acute lymphoblastic 11.3
5 t-cell leukemia 11.1
6 leukemia 11.1
7 myelopathy, htlv-1-associated 11.0
8 lymphoid leukemia 11.0
9 retrovirus-associated myelopathy 11.0
10 lymphoma 11.0
11 hematopoietic stem cell transplantation 10.4
12 clear cell adenofibroma 10.3 CDKN2A TP53
13 lacrimal gland adenoid cystic carcinoma 10.3 CDKN2A TP53
14 plummer vinson syndrome 10.2 CD7 TNFRSF8
15 barbiturate dependence 10.2 CDKN2A IL2 IL2RA
16 spastic paraparesis 10.2
17 spasticity 10.2
18 causalgia 10.2 CNTN2 IL2 IL2RA
19 pericardium leiomyoma 10.2 CDKN2A TP53
20 pseudohypoaldosteronism, type iic 10.2 BCL2L1 FOXP3 IL2RA
21 penile disease 10.2 CD7 CDKN2A TNFRSF8
22 anterior foramen magnum meningioma 10.2 IL2 IL2RA TP53
23 extraocular retinoblastoma 10.2 CCND2 CDKN2A TP53
24 integumentary system benign neoplasm 10.1 CCND2 CDKN2A TP53
25 paroxysmal nocturnal hemoglobinuria 10.1 CDKN2A FOXP3 TP53
26 post-surgical hypoinsulinemia 10.1 CDKN2A IL2 TP53
27 squamous cell papilloma of skin 10.1 CD7 FOXP3 IL2 IL2RA
28 pneumonia 10.1
29 multiple carboxylase deficiency 10.1 CD7 IL2 IL2RA TNFRSF8
30 coarctation of aorta 10.1 CD7 IL2 IL2RA TNFRSF8
31 pleoconial myopathy with salt craving 10.1 CD7 TNFRSF8
32 scabies 10.1
33 mycosis fungoides 10.1
34 peripheral t-cell lymphoma 10.1
35 prostatic urethral cancer 10.1 FAS FOXP3 IL2 IL2RA
36 hemophagocytic lymphohistiocytosis 10.0 IL2 IL2RA PTHLH TNFRSF8
37 dermatitis 10.0
38 hepatitis 10.0
39 endotheliitis 10.0
40 adrenal cortical carcinoma 10.0 BCL2L1 CADM1 CDKN2A TP53
41 autosomal dominant robinow syndrome 3 10.0 FAS IL2 IL2RA
42 congestive heart failure 10.0 FAS FOXP3 IL2 IL2RA
43 melanoma metastasis 10.0 BCL2L1 CCND2 CDKN2A PMAIP1 TP53
44 non-amyloid monoclonal immunoglobulin deposition disease 10.0 FAS IL2RA
45 meningitis 10.0
46 cutaneous t cell lymphoma 10.0
47 follicular mucinosis 10.0
48 strongyloidiasis 10.0
49 bladder disease 10.0 BCL2L1 CCND2 CDKN2A TNFRSF8 TP53
50 anaplastic large cell lymphoma 9.9

Graphical network of the top 20 diseases related to Adult T-Cell Leukemia:



Diseases related to Adult T-Cell Leukemia

Symptoms & Phenotypes for Adult T-Cell Leukemia

GenomeRNAi Phenotypes related to Adult T-Cell Leukemia according to GeneCards Suite gene sharing:

26
id Description GenomeRNAi Source Accession Score Top Affiliating Genes
1 Synthetic lethal with MLN4924 (a NAE inhibitor) GR00250-A-1 9.88 CDKN2A EPC1 FAS IL2 IL2RA BCL2L1
2 Synthetic lethal with MLN4924 (a NAE inhibitor) GR00250-A-2 9.88 CDKN2A EPC1 FAS IL2 IL2RA BCL2L1

MGI Mouse Phenotypes related to Adult T-Cell Leukemia:

44 (show all 14)
id Description MGI Source Accession Score Top Affiliating Genes
1 endocrine/exocrine gland MP:0005379 10.37 BCL11B BCL2L1 CADM1 CCND2 CD7 CDKN2A
2 hematopoietic system MP:0005397 10.36 CDKN2A EPC1 FAS FOXP3 IL2 IL2RA
3 behavior/neurological MP:0005386 10.35 CADM1 CCND2 CDKN2A CNTN2 EPC1 FAS
4 immune system MP:0005387 10.31 BCL11B BCL2L1 CADM1 CCND2 CD7 CDKN2A
5 cellular MP:0005384 10.3 BCL11B BCL2L1 CADM1 CDKN2A FAS FOXP3
6 growth/size/body region MP:0005378 10.29 BCL11B BCL2L1 CADM1 CDKN2A EPC1 FAS
7 homeostasis/metabolism MP:0005376 10.25 IL2RA JUND NFKBIA PTHLH TP53 BCL11B
8 mortality/aging MP:0010768 10.1 TXN BCL11B BCL2L1 CCND2 CDKN2A EPC1
9 digestive/alimentary MP:0005381 10.05 CDKN2A FAS FOXP3 IL2 IL2RA PTHLH
10 integument MP:0010771 9.97 BCL11B BCL2L1 CDKN2A FAS FOXP3 NFKBIA
11 liver/biliary system MP:0005370 9.87 CCND2 CDKN2A FAS FOXP3 IL2 JUND
12 reproductive system MP:0005389 9.85 FAS FOXP3 IL2 JUND PTHLH TP53
13 respiratory system MP:0005388 9.56 CDKN2A FAS FOXP3 IL2 IL2RA JUND
14 vision/eye MP:0005391 9.28 BCL11B CCND2 CDKN2A FAS FOXP3 IL2

Drugs & Therapeutics for Adult T-Cell Leukemia

Drugs for Adult T-Cell Leukemia (from DrugBank, HMDB, Dgidb, PharmGKB, IUPHAR, NovoSeek, BitterDB):

(show top 50) (show all 544)
id Name Status Phase Clinical Trials Cas Number PubChem Id
1
Asparaginase Approved Phase 4,Phase 3,Phase 2,Phase 1 9015-68-3
2
Cyclophosphamide Approved, Investigational Phase 4,Phase 3,Phase 2,Phase 1,Early Phase 1 50-18-0, 6055-19-2 2907
3
Cytarabine Approved, Investigational Phase 4,Phase 3,Phase 2,Phase 1 147-94-4 6253
4
Daunorubicin Approved Phase 4,Phase 3,Phase 2,Phase 1 20830-81-3 30323
5
Dexamethasone Approved, Investigational, Vet_approved Phase 4,Phase 3,Phase 2,Phase 1 50-02-2 5743
6
Doxorubicin Approved, Investigational Phase 4,Phase 3,Phase 2,Phase 1 23214-92-8 31703
7
Etoposide Approved Phase 4,Phase 3,Phase 2,Phase 1,Early Phase 1 33419-42-0 36462
8
Methotrexate Approved Phase 4,Phase 3,Phase 2,Phase 1 1959-05-2, 59-05-2 126941
9
Methylprednisolone Approved, Vet_approved Phase 4,Phase 2,Phase 3,Phase 1 83-43-2 6741
10
Prednisolone Approved, Vet_approved Phase 4,Phase 2,Phase 3,Phase 1 50-24-8 5755
11
Thioguanine Approved Phase 4,Phase 3,Phase 2 154-42-7 2723601
12
Vincristine Approved, Investigational Phase 4,Phase 3,Phase 2,Phase 1 2068-78-2, 57-22-7 5978
13
Vindesine Approved Phase 4,Phase 3,Phase 2 59917-39-4, 53643-48-4 40839
14
Ifosfamide Approved Phase 4,Phase 3,Phase 2,Phase 1 3778-73-2 3690
15
rituximab Approved Phase 4,Phase 3,Phase 2,Phase 1 174722-31-7 10201696
16
Lenograstim Approved Phase 4,Phase 3,Phase 2,Phase 1 135968-09-1
17
Thiotepa Approved Phase 4,Phase 3,Phase 2,Phase 1 52-24-4 5453
18
Epirubicin Approved Phase 4,Phase 2 56420-45-2 41867
19
Gemcitabine Approved Phase 4,Phase 2,Phase 1 95058-81-4 60750
20
Prednisone Approved, Vet_approved Phase 4,Phase 3,Phase 2,Phase 1 53-03-2 5865
21
Teniposide Approved Phase 4,Phase 2 29767-20-2 34698
22
Busulfan Approved, Investigational Phase 4,Phase 2,Phase 3,Phase 1,Early Phase 1 55-98-1 2478
23
alemtuzumab Approved, Investigational Phase 4,Phase 3,Phase 1,Phase 2 216503-57-0
24
Cyclosporine Approved, Investigational, Vet_approved Phase 4,Phase 2,Phase 3,Phase 1 79217-60-0, 59865-13-3 5284373 6435893
25
Hydrocortisone Approved, Vet_approved Phase 4,Phase 3,Phase 2,Phase 1 50-23-7 5754 657311
26
Tacrolimus Approved, Investigational Phase 4,Phase 3,Phase 2,Phase 1 104987-11-3 445643 439492
27
Daclizumab Approved, Investigational Phase 4,Phase 1,Phase 2 152923-56-3
28
Cladribine Approved, Investigational Phase 4,Phase 2,Phase 1 4291-63-8 20279
29
Cisplatin Approved Phase 4,Phase 3,Phase 2,Phase 1 15663-27-1 84093 441203 2767
30
Acetaminophen Approved Phase 4,Phase 2 103-90-2 1983
31
Diphenhydramine Approved Phase 4,Phase 2 58-73-1, 147-24-0 3100
32
Heparin Approved, Investigational Phase 4,Phase 3 9005-49-6 772 46507594
33
Pancrelipase Approved Phase 4,Phase 1 53608-75-6
34
Promethazine Approved Phase 4,Phase 2 60-87-7 4927
35
Folic Acid Approved, Nutraceutical, Vet_approved Phase 4,Phase 3,Phase 2,Phase 1,Early Phase 1 59-30-3 6037
36
leucovorin Approved, Nutraceutical Phase 4,Phase 3,Phase 2,Phase 1,Early Phase 1 58-05-9 54575, 6560146 143
37
Doxil Approved June 1999 Phase 4,Phase 3,Phase 2,Phase 1 31703
38 Antibodies Phase 4,Phase 3,Phase 2,Phase 1
39 Immunoglobulins Phase 4,Phase 3,Phase 2,Phase 1
40 Immunosuppressive Agents Phase 4,Phase 3,Phase 2,Phase 1,Early Phase 1
41 6-Mercaptopurine Phase 4,Phase 3,Phase 2,Phase 1
42 Alkylating Agents Phase 4,Phase 3,Phase 2,Phase 1,Early Phase 1
43 Anti-Bacterial Agents Phase 4,Phase 3,Phase 2,Phase 1,Early Phase 1
44 Antibiotics, Antitubercular Phase 4,Phase 3,Phase 2,Phase 1
45 Antiemetics Phase 4,Phase 3,Phase 2,Phase 1
46 Anti-Infective Agents Phase 4,Phase 3,Phase 2,Phase 1,Early Phase 1
47 Anti-Inflammatory Agents Phase 4,Phase 3,Phase 2,Phase 1
48 Antimetabolites Phase 4,Phase 3,Phase 2,Phase 1
49 Antimetabolites, Antineoplastic Phase 4,Phase 3,Phase 2,Phase 1
50 Antimitotic Agents Phase 4,Phase 3,Phase 2,Phase 1

Interventional clinical trials:

(show top 50) (show all 1066)
id Name Status NCT ID Phase
1 Pilot Study of Combination Therapy With CHOP-Zenapax (CHOP-daclizumab) Completed NCT01418430 Phase 4
2 German Multicenter Trial for the Treatment of Newly Diagnosed T-lymphoblastic Lymphoma in Adults Completed NCT00199017 Phase 4
3 Trial for the Treatment of Newly Diagnosed Mature B-Cell Acute Lymphoblastic Leukemia (B-ALL), Burkitt's Non-Hodgkin's Lymphoma (NHL) and Other High-grade Lymphoma in Adults Completed NCT00199082 Phase 4
4 Bone Marrow Transplantation in Treating Patients With Hematologic Cancer Completed NCT00003398 Phase 4
5 CEOP/IVE/GDP Compared With CEOP as the First-line Therapy for Newly Diagnosed Adult Patients With PTCL Recruiting NCT02533700 Phase 4
6 ATG Could Improve the Outcome Of Hematopoietic Stem Cell Transplant in Patients With Highly Aggressive T Cell Tumors Recruiting NCT02290132 Phase 4
7 ATG Based Conditioning Regimen in HLA Related HSCT for Aggressive T-cell Tumors Recruiting NCT02938741 Phase 4
8 Identification of New Immune Factors Specific of Relapse in Childhood B Lineage Acute Lymphoblastic Leukemia Recruiting NCT02618109 Phase 4
9 Study of Alemtuzumab Versus Anti-thymocyte Globulin to Help Prevent Rejection in Kidney and Pancreas Transplantation Active, not recruiting NCT00331162 Phase 4
10 Combination Chemotherapy With or Without Rituximab in Treating Older Patients With Non-Hodgkin's Lymphoma Unknown status NCT00052936 Phase 3
11 Levofloxacin Compared With Cefepime in Treating Cancer Patients With Fever and Neutropenia Unknown status NCT00020865 Phase 3
12 Early Hospital Discharge or Standard Inpatient Care in Cancer Patients Receiving Antibiotics for Febrile Neutropenia Unknown status NCT00445497 Phase 3
13 Ketamine Hydrochloride and Best Pain Management in Treating Cancer Patients With Neuropathic Pain Unknown status NCT01316744 Phase 3
14 Standard Chemotherapy With or Without Nelarabine or Rituximab in Treating Patients With Newly Diagnosed Acute Lymphoblastic Leukemia Unknown status NCT01085617 Phase 3
15 Risk-Adjusted Combination Chemotherapy in Treating Young Patients With Acute Lymphoblastic Leukemia Unknown status NCT00764907 Phase 3
16 Combination Chemotherapy in Treating Children With Anaplastic Large Cell Lymphoma Unknown status NCT00006455 Phase 3
17 Allogeneic Stem Cell Transplantation in CML With Partial T Cell Depletion Unknown status NCT00966810 Phase 2, Phase 3
18 Decitabine Augments for Post Allogeneic Stem Cell Transplantation in Patients With Acute Myeloid Leukemia and Myelodysplastic Syndrome Unknown status NCT01809392 Phase 2, Phase 3
19 A Study for Aggressive Adult T-cell Leukemia-lymphoma (ATLL) Completed NCT00145002 Phase 3
20 Treatment of Acute Lymphoblastic Leukemia (ALL) in Younger Adults Completed NCT00327678 Phase 3
21 Study of Treatment High Risk and/or Low Risk Acute Lymphoblastic leukémia(ALL) Adults Stage III Completed NCT00483132 Phase 3
22 ALL2008 Protocol for Childhood Acute Lymphoblastic Leukemia (ALL) - 6MP Consolidation Therapy Completed NCT00816049 Phase 3
23 Radiation Therapy in Treating Patients With Relapsed or Refractory Non-Hodgkin's Lymphoma Who Have Undergone Stem Cell Transplantation Completed NCT00031668 Phase 3
24 Levofloxacin to Prevent Infection Following Chemotherapy in Treating Patients With Solid Tumors or Lymphoma Completed NCT00005590 Phase 3
25 Prevention of Infection in Patients With Hematologic Cancer and Persistent Fever Caused by a Low White Blood Cell Count Completed NCT00003805 Phase 3
26 Dalteparin to Prevent Complications in Cancer Patients Receiving Chemotherapy Through a Catheter Completed NCT00006083 Phase 3
27 St. John's Wort in Relieving Fatigue in Patients Undergoing Chemotherapy or Hormone Therapy for Cancer Completed NCT00005805 Phase 3
28 Darbepoetin Alfa With or Without Iron in Treating Anemia Caused By Chemotherapy in Patients With Cancer Completed NCT00661999 Phase 3
29 Darbepoetin Alfa Compared With Epoetin Alfa in Treating Anemia in Patients Receiving Chemotherapy for Cancer Completed NCT00070382 Phase 3
30 Personalized Information or Basic Information in Helping Patients Make Decisions About Participating in a Clinical Trial Completed NCT00750009 Phase 3
31 American Ginseng in Treating Patients With Fatigue Caused by Cancer Completed NCT00719563 Phase 3
32 Opioid Titration Order Sheet or Standard Care in Treating Patients With Cancer Pain Completed NCT00666211 Phase 3
33 Fentanyl Sublingual Spray in Treating Patients With Breakthrough Cancer Pain Completed NCT00538850 Phase 3
34 Liposomal Amphotericin B in Treating Granulocytopenia and Persistent Unexplained Fever in Cancer Patients Completed NCT00003938 Phase 3
35 Caspofungin Acetate Compared With Amphotericin B Liposomal in Treating Patients With Persistent Fever and Neutropenia Following Cancer Treatment Completed NCT00008359 Phase 3
36 Treatment for Chronic Pain in Patients With Advanced Cancer Completed NCT00003687 Phase 3
37 Ondansetron in Treating Patients With Advanced Cancer and Chronic Nausea and Vomiting Not Caused by Cancer Treatment Completed NCT00006348 Phase 3
38 Comparison of Two Combination Chemotherapy Regimens in Treating Adults With Previously Untreated Leukemia or Lymphoma Completed NCT00002766 Phase 3
39 Combination Chemotherapy in Treating Patients With Acute Lymphoblastic Leukemia or Advanced Lymphoblastic Non-Hodgkin's Lymphoma Completed NCT01230983 Phase 3
40 Study About Treatment of Newly Diagnosed Non Cutaneous Peripheral T Cell Lymphoma Completed NCT00970385 Phase 3
41 Bone Marrow Transplantation in Treating Patients With Leukemia, Myelodysplasia, or Lymphoblastic Lymphoma Completed NCT00003187 Phase 2, Phase 3
42 Laboratory-Treated Donor Bone Marrow in Treating Patients Who Are Undergoing a Donor Bone Marrow Transplant for Hematologic Cancer Completed NCT00265837 Phase 3
43 Chronic Graft-versus-host Disease (cGvHD) Prophylaxis With or Without ATG Prior to Stem Cell Transplantation (SCT) From HLA-identical Siblings in Patients With Acute Leukemia Completed NCT00678275 Phase 3
44 Combination Chemotherapy in Treating Young Patients With Relapsed or Refractory Acute Lymphoblastic Leukemia Completed NCT00967057 Phase 3
45 Stem Cell Transplantation for Patients With Hematologic Malignancies Completed NCT00152139 Phase 3
46 Combination Chemotherapy Based on Risk of Relapse in Treating Young Patients With Acute Lymphoblastic Leukemia Completed NCT00430118 Phase 3
47 Haploidentical Stem Cell Transplantation for Patients With Hematologic Malignancies Completed NCT00186823 Phase 3
48 Internet-Based Program With or Without Telephone-Based Problem-Solving Training in Helping Long-Term Survivors of Hematopoietic Stem Cell Transplant Cope With Late Complications Completed NCT00799461 Phase 3
49 Sibling Donor Peripheral Stem Cell Transplant or Sibling Donor Bone Marrow Transplant in Treating Patients With Hematologic Cancers or Other Diseases Completed NCT00438958 Phase 3
50 Music Therapy or Book Discussion in Improving Quality of Life in Young Patients Undergoing Stem Cell Transplant Completed NCT00305851 Phase 3

Search NIH Clinical Center for Adult T-Cell Leukemia

Cell-based therapeutics:


LifeMap Discovery
Data from LifeMap, the Embryonic Development and Stem Cells Database
Read about Adult T-Cell Leukemia cell therapies at LifeMap Discovery.
Stem-cell-based therapeutic approaches for Adult T-Cell Leukemia:
Hematopoietic stem cells for treatment of hematologic malignancies
Embryonic/Adult Cultured Cells Related to Adult T-Cell Leukemia:
Bone marrow-derived hematopoietic stem cells

Cochrane evidence based reviews: leukemia-lymphoma, adult t-cell

Genetic Tests for Adult T-Cell Leukemia

Anatomical Context for Adult T-Cell Leukemia

MalaCards organs/tissues related to Adult T-Cell Leukemia:

39
T Cells, Skin, Bone, Liver, Bone Marrow, Lymph Node, Breast

Publications for Adult T-Cell Leukemia

Articles related to Adult T-Cell Leukemia:

(show top 50) (show all 843)
id Title Authors Year
1
Acute myelitis resembling human T-lymphotropic virus type 1-associated myelopathy presenting as high-signal-intensity long cord lesions on T2-weighted magnetic resonance images combined with lymphoma-type adult T-cell leukemia/lymphoma. ( 27817856 )
2017
2
Hematopoeitic stem cell transplantation for adult T cell leukemia-lymphoma: Who is the best candidate? ( 27786571 )
2017
3
Dismal outcome of allogeneic hematopoietic stem cell transplantation for relapsed adult T-cell leukemia/lymphoma, a Japanese nation-wide study. ( 28067877 )
2017
4
Evaluation of INOS, ICAM-1, and VCAM-1 gene expression: A study of adult T cell leukemia malignancy associated with HTLV-1. ( 28110427 )
2017
5
Crucial role of carbonic anhydrase IX in tumorigenicity of xenotransplanted adult T-cell leukemia-derived cells. ( 28075522 )
2017
6
Oncogenic mutations in the FBXW7 gene of adult T-cell leukemia patients. ( 27247421 )
2016
7
Development of engineered T cells expressing a chimeric CD16-CD3IP receptor to improve the clinical efficacy of mogamulizumab therapy against adult T cell leukemia. ( 27091408 )
2016
8
Effector regulatory T cells reflect the equilibrium between antitumor immunity and autoimmunity in adult T cell leukemia. ( 27215229 )
2016
9
Impaired expression of DICER and some microRNAs in HBZ expressing cells from acute adult T-cell leukemia patients. ( 26849145 )
2016
10
Early leukemic transformation of adult T-cell leukemia/lymphoma presenting as meningeal lymphoma. ( 27862199 )
2016
11
Phase II study of alemtuzumab (CAMPATH-1Ar) in patients with HTLV-1-associated adult T-cell leukemia/lymphoma. ( 27486175 )
2016
12
Transition of adult T-cell leukemia/lymphoma clones during clinical progression. ( 27383637 )
2016
13
Adult T-Cell Leukemia/Lymphoma: Rarely Encountered in the United States. ( 27521318 )
2016
14
Lenalidomide in Adult T-Cell Leukemia/Lymphoma. ( 27863193 )
2016
15
Adult T-cell leukemia/lymphoma in donor cells responding to second allogeneic hematopoietic stem cell transplantation using unrelated cord blood: the Nagasaki Transplant Group experience. ( 27210445 )
2016
16
Clinical significance of CD70 expression on T cells in human T-lymphotropic virus type-1 carriers and adult T cell leukemia/ lymphoma patients. ( 26077361 )
2016
17
Mutation of epigenetic regulators TET2 and MLL3 in patients with HTLV-I-induced acute adult T-cell leukemia. ( 26880370 )
2016
18
Torin2 Potentiates Anticancer Effects on Adult T-Cell Leukemia/Lymphoma by Inhibiting Mammalian Target of Rapamycin. ( 26722032 )
2016
19
All-trans retinoic acid and interferon-I+ increase CD38 expression on adult T-cell leukemia cells and sensitize them to T cells bearing anti-CD38 chimeric antigen receptors. ( 27176797 )
2016
20
Multicenter Phase II Study of Lenalidomide in Relapsed or Recurrent Adult T-Cell Leukemia/Lymphoma: ATLL-002. ( 27621400 )
2016
21
Relationship between triterpenoid anticancer drug resistance, autophagy, and caspase-1 in adult T-cell leukemia. ( 27190722 )
2016
22
Uchiyama T, Yodoi J, Sagawa K, Takatsuki K, Uchino H. Adult T-cell leukemia: clinical and hematologic features of 16 cases. Blood. 1977;50(3):481-492. ( 27979862 )
2016
23
Recurrence of Psoriasis Vulgaris Accompanied by Treatment with C-C Chemokine Receptor Type 4 (CCR4) Antibody (Mogamulizumab) Therapies in a Patient with Adult T cell Leukemia/ Lymphoma: Insight into Autoinflammatory Diseases. ( 27181545 )
2016
24
Adult T-Cell leukemia/lymphoma in the Caribbean cohort is a distinct clinical entity with dismal response to conventional chemotherapy. ( 27341021 )
2016
25
Tax fingerprint in adult T-cell leukemia. ( 27056993 )
2016
26
Induction of apoptosis by HBI-8000 in adult T-cell leukemia/lymphoma is associated with activation of Bim and NLRP3. ( 27193821 )
2016
27
Alopecia areata, thyroiditis and vitiligo vulgaris in a Japanese patient with smoldering type adult T-cell leukemia/lymphoma. ( 27651025 )
2016
28
Effects of first-line chemotherapy on natural killer cells in adult T-cell leukemia-lymphoma and peripheral T-cell lymphoma. ( 27289375 )
2016
29
Adult T cell leukemia aggressivenness correlates with loss of both 5-hydroxymethylcytosine and TET2 expression. ( 27903986 )
2016
30
Ascites Retention during Mogamulizumab Treatment in a Patient with Adult T-cell Leukemia/lymphoma. ( 27374686 )
2016
31
Dysregulation of c-Myb Pathway by Aberrant Expression of Proto-oncogene MYB Provides the Basis for Malignancy in Adult T-cell Leukemia/lymphoma Cells. ( 27307595 )
2016
32
Cytological diagnosis of adult T-cell leukemia/lymphoma in sputum. ( 26972585 )
2016
33
Characterization of patients with aggressive adult T-cell leukemia-lymphoma in Okinawa, Japan: a retrospective analysis of a large cohort. ( 27329124 )
2016
34
Pretransplantation Anti-CCR4 Antibody Mogamulizumab Against Adult T-Cell Leukemia/Lymphoma Is Associated With Significantly Increased Risks of Severe and Corticosteroid-Refractory Graft-Versus-Host Disease, Nonrelapse Mortality, and Overall Mortality. ( 27507878 )
2016
35
An Unusual Association of Adult T-Cell Leukemia/Lymphoma With Hyalohyphomycosis. ( 26981740 )
2016
36
Prolonged lymphocytosis as the first manifestation of Hodgkin-like adult T-cell leukemia/lymphoma. ( 27789281 )
2016
37
TIM-3 expression in lymphoma cells predicts chemoresistance in patients with adult T-cell leukemia/lymphoma. ( 27446463 )
2016
38
Efficiency of AUY922 in mice with adult T-cell leukemia/lymphoma. ( 27347156 )
2016
39
A new mouse model of acute adult T-cell leukemia generated by transplantation of AKT, BCLxL, and HBZ-transduced T cells. ( 27223899 )
2016
40
Friend or foe? Mogamulizumab in allogeneic hematopoietic stem cell transplantation for adult T-cell leukemia/lymphoma. ( 27868052 )
2016
41
Dose-adjusted EPOCH chemotherapy with bortezomib and raltegravir for human T-cell leukemia virus-associated adult T-cell leukemia lymphoma. ( 27015285 )
2016
42
Xenotransplantation elicits salient tumorigenicity of adult T-cell leukemia-derived cells via aberrant AKT activation. ( 26928911 )
2016
43
A Case of Pneumonia Caused by Pneumocystis Jirovecii and Cryptococcus Neoformans in a Patient with HTLV-1 Associated Adult T- Cell Leukemia/Lymphoma: Occam's Razor Blunted. ( 27024978 )
2016
44
Hypomethylation of the Treg-Specific Demethylated Region in FOXP3 Is a Hallmark of the Regulatory T-cell Subtype in Adult T-cell Leukemia. ( 26681759 )
2016
45
JAK2 V617F Mutation in Adult T Cell Leukemia-Lymphoma. ( 27812253 )
2016
46
Successful treatment with mogamulizumab followed by allogeneic hematopoietic stem-cell transplantation in adult T-cell leukemia/lymphoma: a report of two cases. ( 27573760 )
2016
47
Angiotensin II type 1 receptor blocker telmisartan induces apoptosis and autophagy in adult T-cell leukemia cells. ( 27419050 )
2016
48
Genetic landscape of adult T-cell leukemia/lymphoma. ( 27169444 )
2016
49
Six Cases of CD20-Positive Adult T-Cell Leukemia. ( 27980301 )
2016
50
T Cell Receptor VI^ Staining Identifies the Malignant Clone in Adult T cell Leukemia and Reveals Killing of Leukemia Cells by Autologous CD8+ T cells. ( 27893842 )
2016

Variations for Adult T-Cell Leukemia

Expression for Adult T-Cell Leukemia

Search GEO for disease gene expression data for Adult T-Cell Leukemia.

Pathways for Adult T-Cell Leukemia

Pathways related to Adult T-Cell Leukemia according to GeneCards Suite gene sharing:

(show all 41)
id Super pathways Score Top Affiliating Genes
1
Show member pathways
13.72 BCL2L1 CCND2 CDKN2A FAS IL2 IL2RA
2
Show member pathways
12.84 BCL2L1 FAS NFKBIA TP53 TXN
3
Show member pathways
12.77 BCL2L1 CDKN2A FAS NFKBIA PMAIP1 TP53
4
Show member pathways
12.74 CCND2 FAS IL2 IL2RA NFKBIA TP53
5 12.65 BCL2L1 CDKN2A FAS NFKBIA TP53
6
Show member pathways
12.57 BCL2L1 FOXP3 IL2 IL2RA NFKBIA
7 12.55 BCL2L1 CCND2 IL2 IL2RA TP53
8 12.41 BCL11B FAS FOXP3 IL2 IL2RA NFKBIA
9
Show member pathways
12.38 BCL2L1 IL2 IL2RA NFKBIA TP53
10
Show member pathways
12.36 BCL2L1 CCND2 NFKBIA TP53
11
Show member pathways
12.3 CCND2 CDKN2A FAS PMAIP1 TP53
12 12.21 BCL2L1 FAS PMAIP1 TXN
13
Show member pathways
12.18 BCL2L1 CCND2 IL2 IL2RA
14 12.16 CCND2 CDKN2A NFKBIA PMAIP1 TP53
15
Show member pathways
12.05 BCL2L1 CDKN2A NFKBIA TP53
16
Show member pathways
11.99 IL2 IL2RA NFKBIA TP53
17 11.94 CCND2 CDKN2A PMAIP1 TP53
18 11.91 BCL2L1 CCND2 CDKN2A IL2 IL2RA NFKBIA
19 11.83 IL2 JUND NFKBIA
20
Show member pathways
11.78 BCL2L1 FAS PMAIP1
21 11.78 BCL2L1 NFKBIA TP53
22 11.76 BCL2L1 CCND2 CDKN2A FAS PMAIP1 TP53
23 11.75 CCND2 PMAIP1 TP53
24 11.74 CD7 IL2 IL2RA
25 11.73 BCL2L1 JUND TP53 TXN
26
Show member pathways
11.72 FOXP3 IL2 IL2RA
27
Show member pathways
11.69 BCL2L1 NFKBIA TNFRSF8
28 11.58 BCL2L1 CDKN2A FAS PMAIP1 TP53
29
Show member pathways
11.55 FAS NFKBIA TP53
30 11.48 FOXP3 IL2 IL2RA
31
Show member pathways
11.48 BCL2L1 CCND2 FOXP3 IL2 IL2RA
32 11.44 CCND2 NFKBIA TP53
33 11.43 FAS JUND TP53
34 11.34 BCL2L1 PMAIP1 TP53
35
Show member pathways
11.31 FAS FOXP3 IL2 IL2RA
36
Show member pathways
11.29 BCL2L1 FAS NFKBIA PMAIP1
37 11.14 BCL2L1 IL2 NFKBIA
38
Show member pathways
11.13 IL2 IL2RA JUND NFKBIA
39
Show member pathways
11.04 CDKN2A PMAIP1 TP53
40 10.75 BCL2L1 TP53
41 10.73 BCL2L1 CDKN2A FAS IL2 TP53

GO Terms for Adult T-Cell Leukemia

Biological processes related to Adult T-Cell Leukemia according to GeneCards Suite gene sharing:

(show all 25)
id Name GO ID Score Top Affiliating Genes
1 negative regulation of cell proliferation GO:0008285 9.91 BCL11B CDKN2A FOXP3 PTHLH TNFRSF8 TP53
2 regulation of apoptotic process GO:0042981 9.88 BCL2L1 FAS PMAIP1 TP53
3 response to lipopolysaccharide GO:0032496 9.85 FAS JUND NFKBIA TNFRSF8
4 positive regulation of apoptotic process GO:0043065 9.85 BCL2L1 CDKN2A FAS PMAIP1 TNFRSF8 TP53
5 negative regulation of apoptotic process GO:0043066 9.8 BCL11B BCL2L1 CCND2 FAS IL2 NFKBIA
6 activation of cysteine-type endopeptidase activity involved in apoptotic process GO:0006919 9.77 CDKN2A FAS PMAIP1
7 apoptotic process GO:0006915 9.76 BCL2L1 CADM1 CDKN2A FAS IL2RA NFKBIA
8 negative regulation of inflammatory response GO:0050728 9.75 FOXP3 IL2 IL2RA
9 negative regulation of NF-kappaB transcription factor activity GO:0032088 9.73 CDKN2A FOXP3 NFKBIA
10 response to radiation GO:0009314 9.69 BCL2L1 JUND TXN
11 positive regulation of intrinsic apoptotic signaling pathway GO:2001244 9.65 BCL2L1 PMAIP1 TP53
12 extrinsic apoptotic signaling pathway in absence of ligand GO:0097192 9.63 BCL2L1 FAS IL2
13 positive regulation of protein oligomerization GO:0032461 9.62 PMAIP1 TP53
14 negative regulation of immune response GO:0050777 9.62 FOXP3 IL2RA
15 hepatocyte apoptotic process GO:0097284 9.61 BCL2L1 FAS
16 replicative senescence GO:0090399 9.6 CDKN2A TP53
17 positive regulation of regulatory T cell differentiation GO:0045591 9.57 FOXP3 IL2
18 activation-induced cell death of T cells GO:0006924 9.54 FAS IL2RA
19 negative regulation of T-helper 17 cell differentiation GO:2000320 9.52 FOXP3 IL2
20 regulation of mitochondrial membrane permeability GO:0046902 9.5 BCL2L1 PMAIP1 TP53
21 regulation of T cell homeostatic proliferation GO:0046013 9.49 IL2 IL2RA
22 negative regulation of lymphocyte proliferation GO:0050672 9.13 FOXP3 IL2 IL2RA
23 T cell homeostasis GO:0043029 8.92 FAS FOXP3 IL2RA PMAIP1
24 positive regulation of transcription from RNA polymerase II promoter GO:0045944 10.01 BCL11B CDKN2A EPC1 FOXP3 IL2 JUND
25 immune response GO:0006955 10 CD7 FAS IL2 IL2RA TNFRSF8

Molecular functions related to Adult T-Cell Leukemia according to GeneCards Suite gene sharing:

id Name GO ID Score Top Affiliating Genes
1 NF-kappaB binding GO:0051059 8.8 CDKN2A FOXP3 NFKBIA

Sources for Adult T-Cell Leukemia

3 CDC
7 CNVD
9 Cosmic
10 dbSNP
11 DGIdb
16 ExPASy
18 FMA
28 GO
29 GTR
30 HGMD
31 HMDB
32 HPO
33 ICD10
34 ICD10 via Orphanet
35 ICD9CM
36 IUPHAR
37 KEGG
38 LifeMap
40 MedGen
42 MeSH
43 MESH via Orphanet
44 MGI
46 NCI
47 NCIt
48 NDF-RT
51 NINDS
52 Novoseek
54 OMIM
55 OMIM via Orphanet
59 PubMed
60 QIAGEN
65 SNOMED-CT via Orphanet
67 TGDB
68 Tocris
69 UMLS
70 UMLS via Orphanet
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