ATLL
MCID: ADL017
MIFTS: 53

Adult T-Cell Leukemia (ATLL) malady

Cancer diseases, Skin diseases, Blood diseases, Immune diseases categories

Summaries for Adult T-Cell Leukemia

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8Disease Ontology, 32MalaCards
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Disease Ontology:8 A t-cell leukemia that results in abnormal increase of lymphocytes, derives from t-cells, has material basis in human t-lymphotropic virus 1, which is transmitted by sexual contact, transmitted by contaminated needles used by intravenous-drug users, and transmitted by breast feeding. the infection results in formation of skin lesions.

MalaCards: Adult T-Cell Leukemia, also known as adult t-cell leukemia/lymphoma, is related to t-cell leukemia and leukemia. An important gene associated with Adult T-Cell Leukemia is PMAIP1 (phorbol-12-myristate-13-acetate-induced protein 1), and among its related pathways are Rho Family GTPases and PEDF Induced Signaling. The compounds ccl4 and [alcl] have been mentioned in the context of this disorder. Affiliated tissues include t cells, skin and breast.

Aliases & Classifications for Adult T-Cell Leukemia

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Sources:
8Disease Ontology, 10DISEASES, 44Novoseek, 48Orphanet, 30LifeMap Discovery™, 60UMLS, 35MESH via Orphanet, 26ICD10 via Orphanet, 57SNOMED-CT via Orphanet, 61UMLS via Orphanet, 25ICD10
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Classifications:

Malacards categories (disease lists): (See all malacards categories)
Global: Cancer diseases
Anatomical: Skin diseases, Blood diseases, Immune diseases


Characteristics (Orphanet epidemiological data):

48
adult t-cell leukemia/lymphoma:
Age of onset: Adulthood


Aliases & Descriptions:

adult t-cell leukemia 8 10 30
adult t-cell leukemia/lymphoma 8 48
t cell leukemia lymphoma adult 44
adult t-cell lymphoma/leukemia 60
atll 48


External Ids:

Disease Ontology8 DOID:0050523
MESH via Orphanet35 D015459
ICD10 via Orphanet26 C91.5
SNOMED-CT via Orphanet57 110007008, 188729005, 77430005
UMLS via Orphanet61 C0023493
ICD1025 C91.5

Related Diseases for Adult T-Cell Leukemia

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Sources:
17GeneCards, 18GeneDecks
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Diseases in the Acute T Cell Leukemia family:

adult t-cell leukemia T-Cell Leukemia
Leukemia, B-Cell, Chronic Leukemia, T-Cell, Chronic
Human T-Cell Leukemia Virus Type 1 Human T-Cell Leukemia Virus Type 2
Human T-Cell Leukemia Virus Type 3

Diseases related to Adult T-Cell Leukemia via text searches within MalaCards or GeneCards/GeneDecks gene sharing:

(show top 50)    (show all 105)
idRelated DiseaseScoreTop Affiliating Genes
1t-cell leukemia32.3TXN, CCR4, TNFRSF8, HTLVR, CNTN2, CD7
2leukemia32.3TCL1A, HTLVR, CNTN2, CD7
3cutaneous t cell lymphoma31.1CCR4, CCR10, TNFRSF8
4mycosis fungoides30.7CCL22, CCR4, CCR10, TNFRSF8, CD7
5dermatitis30.7CCR10, CCR4, CCL22
6hodgkin's lymphoma30.4CCL22, CCR4, TNFRSF8, TCL1A
7rheumatoid arthritis30.2TXN, CCR4, TNFRSF8, HTLVR, CNTN2, CD7
8arthritis30.2TXN
9hepatitis b30.2MAGEA4, TNFRSF8, TXN
10severe combined immunodeficiency30.2TNFRSF8
11adult lymphoma11.4
12acute t cell leukemia10.9
13acute leukemia10.9
14hypercalcemia10.7
15tropical spastic paraparesis10.7
16adult syndrome10.6
17bone lymphoma10.5
18scabies10.5
19pneumonia10.5
20strongyloidiasis10.4
21central nervous system leukemia10.4
22t cell deficiency10.4
23graft versus host disease10.4
24lymphoid leukemia10.4
25norwegian scabies10.4
26acute pancreatitis10.4
27follicular mucinosis10.4
28anaplastic large cell lymphoma10.4
29eosinophilia10.4
30hepatitis10.4
31meningitis10.4
32myeloid leukemia10.4
33pancreatitis10.4
34retinitis10.4
35acute liver failure10.3
36colon lymphoma10.3
37central nervous system lymphoma10.3
38acute myeloid leukemia10.3
39pancytopenia10.3
40herpes simplex10.3
41monocytic leukemia10.3
42neuropathy10.3
43non-hodgkin lymphoma10.3
44erythema multiforme10.3
45papillary carcinoma10.3
46papillary thyroid carcinoma10.3
47paranasal sinus lymphoma10.1
48retinal ischemia10.1
49tracheal stenosis10.1
50thyroid lymphoma10.1

Graphical network of the top 20 diseases related to Adult T-Cell Leukemia:



Diseases related to adult t-cell leukemia

Clinical Features for Adult T-Cell Leukemia

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Drugs & Therapeutics for Adult T-Cell Leukemia

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Sources:
5CenterWatch, 41NIH Clinical Center, 6ClinicalTrials, 30LifeMap Discovery™, 60UMLS, 40NDF-RT
See all sources

Approved drugs:

Search CenterWatch for Adult T-Cell Leukemia

Drug clinical trials:

Search ClinicalTrials for Adult T-Cell Leukemia

Search NIH Clinical Center for Adult T-Cell Leukemia

Search CenterWatch for Adult T-Cell Leukemia

Cell-based therapeutics:


LifeMap Discovery
The database of embryonic development, stem cell research and regenerative medicine
Read about Adult T-Cell Leukemia cell therapies at LifeMap Discovery.
Stem-cell-based therapeutic approaches for Adult T-Cell Leukemia:
Hematopoietic stem cells for treatment of hematologic malignancies
Embryonic/Adult Cultured Cells Related to Adult T-Cell Leukemia:
Bone marrow-derived hematopoietic stem cells

Genetic Tests for Adult T-Cell Leukemia

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Anatomical Context for Adult T-Cell Leukemia

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Sources:
32MalaCards
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MalaCards organs/tissues related to Adult T-Cell Leukemia:

32
T cells, Skin, Breast, Bone, Lung, B cells, Endothelial, Liver, Myeloid, Bone marrow, Colon, Monocytes, Thyroid, Retina, Lymph node, Testis, Thymus

Animal Models for Adult T-Cell Leukemia or affiliated genes

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Publications for Adult T-Cell Leukemia

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Sources:
50PubMed
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Articles related to Adult T-Cell Leukemia:

(show top 50)    (show all 744)
idTitleAuthorsYear
1
A case of adult T-cell leukemia presenting primary SjAPgren's syndrome-like symptoms. (23992276)
2013
2
Potential contribution of a novel Tax epitope-specific CD4+ T cells to graft-versus-Tax effect in adult T cell leukemia patients after allogeneic hematopoietic stem cell transplantation. (23475215)
2013
3
Impact of graft-versus-host disease on allogeneic hematopoietic cell transplantation for adult T cell leukemia-lymphoma focusing on preconditioning regimens: nationwide retrospective study. (24090597)
2013
4
The combination of arsenic, interferon-alpha, and zidovudine restores an "immunocompetent-like" cytokine expression profile in patients with adult T-cell leukemia lymphoma. (23962110)
2013
5
Outcome of treatment with a low cost protocol in adults with T cell acute lymphoblastic leukemia in a tertiary care center in India. (23772647)
2013
6
Mogamulizumab for the treatment of adult T-cell leukemia/lymphoma. (23110261)
2012
7
Adult T-cell leukemia/lymphoma. (22773213)
2012
8
CADM1/TSLC1 is a novel cell surface marker for adult T-cell leukemia/lymphoma. (22706526)
2012
9
Impact of miR-155 and miR-126 as novel biomarkers on the assessment of disease progression and prognosis in adult T-cell leukemia. (22884882)
2012
10
Disseminated Strongyloides stercoralis infection in HTLV-1-associated adult T-cell leukemia/lymphoma. (21474923)
2011
11
CADM1 interacts with Tiam1 and promotes invasive phenotype of human T-cell leukemia virus type I-transformed cells and adult T-cell leukemia cells. (20215110)
2010
12
HTLV-1 and adult T-cell leukemia: insights into viral transformation of cells 30 years after virus discovery. (20970064)
2010
13
Reactive erythema secondary to adult T-cell leukemia and Helicobacter cinaedi bacteremia. (20235304)
2010
14
Expression profiles of adult T-cell leukemia-lymphoma and associations with clinical responses to zidovudine and interferon alpha. (20370541)
2010
15
Adult T cell leukemia-lymphoma with testicular involvement. (18941745)
2009
16
Intestinal strongyloidiasis as a presenting symptom of HTLV-1-associated adult T-cell leukemia/lymphoma. (19866424)
2009
17
Case of adult T-cell leukemia with pulmonary involvement presenting as nodular shadows. (18419680)
2008
18
Clinical efficacy of all-trans retinoic acid for treating adult T cell leukemia. (18008086)
2008
19
Implication of the HTLV-I bZIP factor gene in the leukemogenesis of adult T-cell leukemia. (17875522)
2007
20
Dehydroxymethylepoxyquinomicin (DHMEQ) therapy reduces tumor formation in mice inoculated with tax-deficient adult T-cell leukemia-derived cell lines. (17764832)
2007
21
Two cases of secondary acute myeloid leukemia accompanying adult T-cell leukemia/lymphoma. (17261499)
2007
22
VCAP-AMP-VECP compared with biweekly CHOP for adult T-cell leukemia-lymphoma: Japan Clinical Oncology Group Study JCOG9801. (17968021)
2007
23
HTLV-I viral escape and host genetic changes in the development of adult T cell leukemia. (16052518)
2006
24
A family predisposition to adult T-cell leukemia. (17142956)
2006
25
Allogeneic hematopoietic stem cell transplantation provides sustained long-term survival for patients with adult T-cell leukemia/lymphoma. (15744352)
2005
26
Inactivation of tumor suppressor genes and the progression of adult T-cell leukemia-lymphoma. (16236609)
2005
27
Flow cytometric immunophenotyping of adult T-cell leukemia/lymphoma using CD3 gating. (16040289)
2005
28
Tax-independent constitutive IkappaB kinase activation in adult T-cell leukemia cells. (15153339)
2004
29
Adult T-cell leukemia/lymphoma (ATLL): report of two fully documented Hellenic patients. (15160945)
2004
30
Chemotherapy targeting methylthioadenosine phosphorylase (MTAP) deficiency in adult T cell leukemia (ATL). (12200696)
2002
31
Autocrine antiapoptotic stimulation of cultured adult T-cell leukemia cells by overexpression of the chemokine I-309. (11493464)
2001
32
Soluble Fas (APO-1/CD95) isoform in adult T-cell leukemia. (11342370)
2001
33
p53 stabilization and functional impairment in the absence of genetic mutation or the alteration of the p14(ARF)-MDM2 loop in ex vivo and cultured adult T-cell leukemia/lymphoma cells. (10845931)
2000
34
Multiple osteolysis of peripheral extremities in a patient with adult T cell leukemia/lymphoma. (10526948)
1999
35
Induction of adult T-cell leukemia-like lymphoproliferative disease and its inhibition by adoptive immunotherapy in T-cell-deficient nude rats inoculated with syngeneic human T-cell leukemia virus type 1-immortalized cells. (10364355)
1999
36
Oral administration of human T-cell leukemia virus type 1 induces immune unresponsiveness with persistent infection in adult rats. (9696824)
1998
37
Deletions of p15 and/or p16 genes as a poor-prognosis factor in adult T-cell leukemia. (9164185)
1997
38
Increased expression of human thioredoxin/adult T cell leukemia-derived factor in SjAPgren's syndrome. (8639174)
1996
39
Adult T-cell leukemia/lymphoma on a background of clonally expanding human T-cell leukemia virus type-1-positive cells. (8977257)
1996
40
Human T-cell lymphotropic virus type-I (HTLV-I)-associated myelopathy/tropical spastic paraparesis with acute type of adult T-cell leukemia. (8774979)
1995
41
Adult T cell leukemia following HTLV-I-associated myelopathy/tropical spastic paraparesis: case reports and implication to the natural course of ATL. (7564523)
1995
42
Neuroprotection by glial cells through adult T cell leukemia-derived factor/human thioredoxin (ADF/TRX). (7953744)
1994
43
Problems concerned with adult T-cell leukemia. 1) Causes of death and early diagnosis of cytomegalovirus pneumonia in adult T-cell leukemia. 2) Clinicopathological features of CD30 positive adult T-cell leukemia]. (7869589)
1994
44
Regulation of eosinophil migration by adult T cell leukemia-derived factor. (8228251)
1993
45
Detection of granulocyte-macrophage colony-stimulating factor activity in the supernatant of the cultured leukemic cells of adult T-cell leukemia with eosinophilia]. (8450613)
1993
46
Tumor necrosis factor-beta in the serum of adult T-cell leukemia with hypercalcemia. (2039827)
1991
47
Constitutive expression of parathyroid hormone-related protein gene in human T cell leukemia virus type 1 (HTLV-1) carriers and adult T cell leukemia patients that can be trans-activated by HTLV-1 tax gene. (2388034)
1990
48
Interleukin-2 receptor beta-chain (p70-75) expressed on leukemic cells from adult T cell leukemia patients. (2121691)
1990
49
Sequence variants of human T-cell lymphotropic virus type I from patients with tropical spastic paraparesis and adult T-cell leukemia do not distinguish neurological from leukemic isolates. (2304144)
1990
50
Severe diarrhea and intestinal strongyloidiasis in a patient with adult T-cell leukemia. (3877392)
1985

Genetic Variations for Adult T-Cell Leukemia

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Expression for genes affiliated with Adult T-Cell Leukemia

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Sources:
1BioGPS, 15Gene Expression Omnibus DataSets
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Expression patterns in normal tissues for genes affiliated with Adult T-Cell Leukemia

Search GEO for disease gene expression data for Adult T-Cell Leukemia.

Pathways for genes affiliated with Adult T-Cell Leukemia

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Sources:
51QIAGEN, 29KEGG, 53Reactome
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Compounds for genes affiliated with Adult T-Cell Leukemia

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Sources:
44Novoseek, 28IUPHAR, 59Tocris Bioscience
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Compounds related to Adult T-Cell Leukemia according to GeneCards/GeneDecks:

idCompoundScoreTop Affiliating Genes
1ccl444 2811.7PTHLH, CCR4, CCL22
2[alcl]4410.6TNFRSF8, CCR4
3larc4410.5CCR4, CCL22
4cyclosporin a44 28 5912.4TXN, CCL22, TNFRSF8, CNTN2

GO Terms for genes affiliated with Adult T-Cell Leukemia

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16Gene Ontology
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Biological processes related to Adult T-Cell Leukemia according to GeneCards/GeneDecks:

idNameGO IDScoreTop Affiliating Genes
1immune responseGO:00695510.7CD7, CCR10, CCR4, CCL22
2chemotaxisGO:00693510.4CCR10, CCR4, CCL22

Molecular functions related to Adult T-Cell Leukemia according to GeneCards/GeneDecks:

idNameGO IDScoreTop Affiliating Genes
1C-C chemokine receptor activityGO:01649310.6CCR10, CCR4

Products for genes affiliated with Adult T-Cell Leukemia

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Sources for Adult T-Cell Leukemia

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3CDC
13ExPASy
14FMA
22GTR
23HGMD
24HMDB
25ICD10
26ICD10 via Orphanet
27ICD9CM
28IUPHAR
29KEGG
34MeSH
35MESH via Orphanet
36MGI
39NCIt
40NDF-RT
43NINDS
44Novoseek
46OMIM
47OMIM via Orphanet
50PubMed
51QIAGEN
57SNOMED-CT via Orphanet
60UMLS
61UMLS via Orphanet