ATLL
MCID: ADL017
MIFTS: 47

Adult T-Cell Leukemia (ATLL) malady

Cancer, Skin, Blood, Immune categories

Summaries for Adult T-Cell Leukemia

Sources:
8Disease Ontology, 33MalaCards
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Disease Ontology:8 A t-cell leukemia that results in abnormal increase of lymphocytes, derives from t-cells, has material basis in human t-lymphotropic virus 1, which is transmitted by sexual contact, transmitted by contaminated needles used by intravenous-drug users, and transmitted by breast feeding. the infection results in formation of skin lesions.

MalaCards: Adult T-Cell Leukemia, also known as adult t-cell leukemia/lymphoma, is related to t-cell leukemia and mycosis fungoides. An important gene associated with Adult T-Cell Leukemia is PMAIP1 (phorbol-12-myristate-13-acetate-induced protein 1), and among its related pathways are Rho Family GTPases and PEDF Induced Signaling. The compounds ccl4 and [alcl] have been mentioned in the context of this disorder. Affiliated tissues include skin, liver and lymph node.

Aliases & Classifications for Adult T-Cell Leukemia

Sources:
8Disease Ontology, 10DISEASES, 31LifeMap Discovery™, 49Orphanet, 45Novoseek, 61UMLS, 36MESH via Orphanet, 26ICD10 via Orphanet, 58SNOMED-CT via Orphanet, 62UMLS via Orphanet, 25ICD10
See all sources

Classifications:

Malacards categories (disease lists): (See all malacards categories)
Global: Cancer
Anatomical: Skin, Blood, Immune


Characteristics (Orphanet epidemiological data):

49
adult t-cell leukemia/lymphoma:
Age of onset: Adulthood


Aliases & Descriptions:

adult t-cell leukemia 8 10 31
adult t-cell leukemia/lymphoma 8 49
t cell leukemia lymphoma adult 45
adult t-cell lymphoma/leukemia 61
atll 49


External Ids:

Disease Ontology8 DOID:0050523
MESH via Orphanet36 D015459
ICD10 via Orphanet26 C91.5
SNOMED-CT via Orphanet58 110007008, 188729005, 77430005
UMLS via Orphanet62 C0023493
ICD1025 C91.5

Related Diseases for Adult T-Cell Leukemia

Sources:
17GeneCards, 18GeneDecks
See all sources

Diseases related to Adult T-Cell Leukemia via text searches within MalaCards or GeneCards/GeneDecks gene sharing:

(show top 50)    (show all 100)
idRelated DiseaseScoreTop Affiliating Genes
1t-cell leukemia32.1TXN, CCR4, TNFRSF8, HTLVR, CNTN2, CD7
2mycosis fungoides30.7CCL22, CCR4, CCR10, TNFRSF8, CD7
3peripheral t-cell lymphoma30.6TCL1A, TNFRSF8, CCR4
4arthritis30.2TXN
5adult lymphoma11.4
6leukemia/lymphoma, t-cell11.2
7acute leukemia10.9
8hematopoietic stem cell transplantation10.8
9acute t cell leukemia10.7
10hypercalcemia10.7
11tropical spastic paraparesis10.7
12spastic paraparesis10.7
13adult syndrome10.6
14bone lymphoma10.5
15strongyloidiasis10.5
16colon lymphoma10.5
17central nervous system leukemia10.5
18plasma cell leukemia10.5
19graft versus host disease10.4
20lymphoid leukemia10.4
21norwegian scabies10.4
22acute pancreatitis10.4
23follicular mucinosis10.4
24anaplastic large cell lymphoma10.4
25follicular lymphoma10.4
26acute liver failure10.3
27central nervous system lymphoma10.3
28acute myeloid leukemia10.3
29pancytopenia10.3
30null-cell leukemia10.3
31acute myeloid leukemia, adult10.3
32leukemia, t-cell, chronic10.3
33diffuse panbronchiolitis10.3
34chronic actinic dermatitis10.3
35primary bone lymphoma10.3
36erythema multiforme10.3
37papillary carcinoma10.3
38squamous cell papilloma10.2
39paranasal sinus lymphoma10.2
40hepatitis c10.2
41retinal ischemia10.2
42tracheal stenosis10.2
43thyroid lymphoma10.2
44adult respiratory distress syndrome10.2
45testicular leukemia10.2
46mixed connective tissue disease10.2
47hypoparathyroidism10.2
48stevens-johnson syndrome10.2
49testicular lymphoma10.2
50systemic lupus erythematosus10.2

Graphical network of the top 20 diseases related to Adult T-Cell Leukemia:



Diseases related to adult t-cell leukemia

Clinical Features for Adult T-Cell Leukemia

Drugs & Therapeutics for Adult T-Cell Leukemia

Sources:
5CenterWatch, 42NIH Clinical Center, 6ClinicalTrials, 31LifeMap Discovery™, 61UMLS, 41NDF-RT
See all sources

Approved drugs:

Search CenterWatch for Adult T-Cell Leukemia

Drug clinical trials:

Search ClinicalTrials for Adult T-Cell Leukemia

Search NIH Clinical Center for Adult T-Cell Leukemia

Search CenterWatch for Adult T-Cell Leukemia

Cell-based therapeutics:


LifeMap Discovery
The database of embryonic development, stem cell research and regenerative medicine
Read about Adult T-Cell Leukemia cell therapies at LifeMap Discovery.
Stem-cell-based therapeutic approaches for Adult T-Cell Leukemia:
Hematopoietic stem cells for treatment of hematologic malignancies
Embryonic/Adult Cultured Cells Related to Adult T-Cell Leukemia:
Bone marrow-derived hematopoietic stem cells

Genetic Tests for Adult T-Cell Leukemia

Anatomical Context for Adult T-Cell Leukemia

Sources:
33MalaCards
See all sources

MalaCards organs/tissues related to Adult T-Cell Leukemia:

33
Skin, Liver, Lymph node, Lung, Bone marrow, Thymus, Retina, Thyroid, Breast, Testis, Myeloid, T cells, B lymphoblasts, B cells, Endothelial

Animal Models for Adult T-Cell Leukemia or affiliated genes

Sources:
28inGenious Targeting Laboratory
See all sources

Publications for Adult T-Cell Leukemia

Sources:
51PubMed
See all sources

Articles related to Adult T-Cell Leukemia:

(show top 50)    (show all 361)
idTitleAuthorsYear
1
Stevens-Johnson Syndrome associated with mogamulizumab treatment of adult T-cell leukemia / lymphoma. (23360455)
2013
2
Treatment of relapsed adult T-cell leukemia/lymphoma after allogeneic hematopoietic stem cell transplantation: the Nagasaki Transplant Group experience. (23100309)
2013
3
Aggressive adult T cell leukemia/lymphoma: the tip of the iceberg of the hidden human T cell lymphotropic virus type 1 infection burden in nonendemic countries. (23228220)
2013
4
Adult T-cell leukemia/lymphoma triggered by adalimumab. (23911677)
2013
5
SOX4 is a direct target gene of FRA-2 and induces expression of HDAC8 in adult T-cell leukemia/lymphoma. (23482931)
2013
6
Attenuation of an adult T-cell leukemia skin lesion after treatment of a concomitant herpes simplex infection: a case study. (23021252)
2012
7
Unrelated cord blood transplantation for patients with adult T-cell leukemia/lymphoma: experience at a single institute. (22976114)
2012
8
Radiation therapy for the management of patients with HTLV-1-associated adult T-cell leukemia/lymphoma. (22730536)
2012
9
Clonal evolution of adult T-cell leukemia/lymphoma takes place in the lymph nodes. (21447829)
2011
10
One-antigen mismatched related versus HLA-matched unrelated donor hematopoietic stem cell transplantation in adults with acute leukemia: Center for International Blood and Marrow Transplant Research results in the era of molecular HLA typing. (20674756)
2011
11
Trends in HTLV-1 prevalence and incidence of adult T-cell leukemia/lymphoma in Nagasaki, Japan. (20166187)
2010
12
Long-term study of indolent adult T-cell leukemia-lymphoma. (20348391)
2010
13
Complete paraplegia after nelarabine treatment in a T-cell acute lymphoblastic leukemia adult patient. (20658590)
2010
14
Transplantation of allogeneic hematopoietic stem cells for adult T-cell leukemia: a nationwide retrospective study. (20479287)
2010
15
Single-cell analysis of T-cell receptor repertoire of HTLV-1 Tax-specific cytotoxic T cells in allogeneic transplant recipients with adult T-cell leukemia/lymphoma. (20647322)
2010
16
Retraction. Sawada S, Ishikawa C, Tanji H, Nakachi S, Senba M, Okudaira T, Uchihara J-N, Taira N, Ohshiro K, Yamada Y, Tanaka Y, Uezato H, Ohshima K, Sasai K, Burgering BMT, Duc Dodon M, Fujii M, Sunakawa H, Mori N. Overexpression of caveolin-1 in adult T-cell leukemia. Blood. 2010; 115(11):2220-2230. (20574044)
2010
17
Identification of cancer stem cells in a Tax-transgenic (Tax-Tg) mouse model of adult T-cell leukemia/lymphoma. (19584402)
2009
18
Early sequential development of infective dermatitis, human T cell lymphotropic virus type 1-associated myelopathy, and adult T cell leukemia/lymphoma. (18173359)
2008
19
Thymic adult T-cell acute lymphoblastic leukemia stratified in standard- and high-risk group by aberrant HOX11L2 expression: experience of the German multicenter ALL study group. (18368072)
2008
20
Therapeutic potential of arsenic trioxide with or without interferon-alpha for relapsed/refractory adult T-cell leukemia/lymphoma. (17488707)
2007
21
Allogeneic bone marrow transplantation from unrelated human T-cell leukemia virus-I-negative donors for adult T-cell leukemia/lymphoma: retrospective analysis of data from the Japan Marrow Donor Program. (17222757)
2007
22
Identification of HLA class I-restricted tumor-associated antigens in adult T cell leukemia cells by mass spectrometric analysis. (17046569)
2006
23
Transcriptional regulation of parathyroid hormone-related protein promoter P3 by ETS-1 in adult T-cell leukemia/lymphoma. (15889157)
2005
24
Identification of two new HLA-A*1101-restricted tax epitopes recognized by cytotoxic T lymphocytes in an adult T-cell leukemia patient after hematopoietic stem cell transplantation. (16014972)
2005
25
Overexpression of a cell adhesion molecule, TSLC1, as a possible molecular marker for acute-type adult T-cell leukemia. (15471956)
2005
26
Telomerase activity and telomere length as prognostic factors of adult T-cell leukemia. (15621829)
2005
27
Minimal residual disease (MRD) monitoring using rearrangement of T-cell receptor and immunoglobulin H gene in the treatment of adult acute lymphoblastic leukemia patients. (16247752)
2005
28
Production of thymus and activation-regulated chemokine and macrophage-derived chemokine by CCR4+ adult T-cell leukemia cells. (15788694)
2005
29
Prolonged remission of adult T-cell leukemia/lymphoma treated with interferon-gamma following autologous peripheral blood stem cell transplantation. (16263592)
2005
30
Inactivation of tumor suppressor genes and the progression of adult T-cell leukemia-lymphoma. (16236609)
2005
31
Rapid tumor death model for evaluation of new therapeutic agents for adult T-cell leukemia. (14688803)
2004
32
Graft-versus-Tax response in adult T-cell leukemia patients after hematopoietic stem cell transplantation. (14729650)
2004
33
Rearranged T-cell receptor beta genes represent powerful targets for quantification of minimal residual disease in childhood and adult T-cell acute lymphoblastic leukemia. (14961040)
2004
34
Frequent expression of CCR4 in adult T-cell leukemia and human T-cell leukemia virus type 1-transformed T cells. (11861261)
2002
35
Treatment of adult T-cell leukemia-lymphoma by CHOP followed by therapy with antinucleosides, alpha interferon and oral etoposide. (12613513)
2002
36
HLA-A*26, HLA-B*4002, HLA-B*4006, and HLA-B*4801 alleles predispose to adult T cell leukemia: the limited recognition of HTLV type 1 tax peptide anchor motifs and epitopes to generate anti-HTLV type 1 tax CD8(+) cytotoxic T lymphocytes. (11485622)
2001
37
Adult T-cell leukemia with anti-HTLV-I antibody but no HTLV-I DNA in tumor cells. (11408714)
2001
38
Prevention of adult T-cell leukemia-like lymphoproliferative disease in rats by adoptively transferred T cells from a donor immunized with human T-cell leukemia virus type 1 Tax-coding DNA vaccine. (11000233)
2000
39
Human T-cell leukemia virus-1 encoded Tax protein transactivates alpha 1-->3 fucosyltransferase Fuc-T VII, which synthesizes sialyl Lewis X, a selectin ligand expressed on adult T-cell leukemia cells. (9070245)
1997
40
Association between expression of intercellular adhesion molecule-1 and integration of human T-cell-leukemia virus type 1 in adult T-cell leukemia cells. (9219058)
1997
41
Increased expression of thioredoxin/adult T-cell leukemia-derived factor in cisplatin-resistant human cancer cell lines. (9816187)
1996
42
Treatment with a combination of zidovudine and alpha-interferon in naive and pretreated adult T-cell leukemia/lymphoma patients. (8797722)
1996
43
Suppression of adult T cell leukemia-derived factor/human thioredoxin induction by FK506 and cyclosporin A: a new mechanism of immune modulation via redox control. (7577807)
1995
44
Unintegrated HTLV-I proviral DNA in cell lines and uncultured peripheral blood mononuclear cells from tropical spastic paraparesis (TSP/HAM) and adult T-cell leukemia (ATL) patients. (7994613)
1994
45
Variant type of sialyl Lewis X antigen expressed on adult T cell leukemia cells is associated with skin involvement. (7987853)
1994
46
Novel interleukin-2 dependent T-cell line derived from adult T-cell leukemia not associated with human T-cell leukemia virus type I. (8390425)
1993
47
Human T lymphotropic virus type-I (HTLV-I) immortalizes human T cells in vitro--its implication in the pathogenesis of adult T cell leukemia (ATL). (1419953)
1992
48
ADF (adult T cell leukemia-derived factor)/human thioredoxin and viral infection: possible new therapeutic approach. (1329444)
1992
49
Coexpression of adult T-cell leukemia-derived factor, a human thioredoxin homologue, and human papillomavirus DNA in neoplastic cervical squamous epithelium. (1654198)
1991
50
HTLV-I, adult T-cell leukemia, and tropical spastic paraparesis. (2894811)
1988

Genetic Variations for Adult T-Cell Leukemia

Expression for genes affiliated with Adult T-Cell Leukemia

Sources:
1BioGPS, 15Gene Expression Omnibus DataSets
See all sources
Expression patterns in normal tissues for genes affiliated with Adult T-Cell Leukemia

Search GEO for disease gene expression data for Adult T-Cell Leukemia.

Pathways for genes affiliated with Adult T-Cell Leukemia

Sources:
52QIAGEN, 30KEGG, 54Reactome
See all sources

Compounds for genes affiliated with Adult T-Cell Leukemia

Sources:
45Novoseek, 29IUPHAR, 60Tocris Bioscience
See all sources

Compounds related to Adult T-Cell Leukemia according to GeneCards/GeneDecks:

idCompoundScoreTop Affiliating Genes
1ccl445 2911.7PTHLH, CCR4, CCL22
2[alcl]4510.6TNFRSF8, CCR4
3larc4510.5CCR4, CCL22
4cyclosporin a45 29 6012.4TXN, CCL22, TNFRSF8, CNTN2

GO Terms for genes affiliated with Adult T-Cell Leukemia

Sources:
16Gene Ontology
See all sources

Biological processes related to Adult T-Cell Leukemia according to GeneCards/GeneDecks:

idNameGO IDScoreTop Affiliating Genes
1immune responseGO:00695510.7CD7, CCR10, CCR4, CCL22
2chemotaxisGO:00693510.4CCR10, CCR4, CCL22

Molecular functions related to Adult T-Cell Leukemia according to GeneCards/GeneDecks:

idNameGO IDScoreTop Affiliating Genes
1C-C chemokine receptor activityGO:01649310.6CCR10, CCR4

Products for genes affiliated with Adult T-Cell Leukemia

  • Antibodies
  • Proteins
  • Lysates
  • Antibodies

Sources for Adult T-Cell Leukemia

3CDC
13ExPASy
14FMA
22GTR
23HGMD
24HMDB
25ICD10
26ICD10 via Orphanet
27ICD9CM
29IUPHAR
30KEGG
35MeSH
36MESH via Orphanet
37MGI
40NCIt
41NDF-RT
44NINDS
45Novoseek
47OMIM
48OMIM via Orphanet
51PubMed
52QIAGEN
58SNOMED-CT via Orphanet
61UMLS
62UMLS via Orphanet