ATLL
MCID: ADL017
MIFTS: 53

Adult T-Cell Leukemia (ATLL) malady

Cancer diseases, Skin diseases, Blood diseases, Immune diseases categories

Summaries for Adult T-Cell Leukemia

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8Disease Ontology, 32MalaCards
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Disease Ontology:8 A t-cell leukemia that results in abnormal increase of lymphocytes, derives from t-cells, has material basis in human t-lymphotropic virus 1, which is transmitted by sexual contact, transmitted by contaminated needles used by intravenous-drug users, and transmitted by breast feeding. the infection results in formation of skin lesions.

MalaCards: Adult T-Cell Leukemia, also known as adult t-cell leukemia/lymphoma, is related to t-cell leukemia and leukemia. An important gene associated with Adult T-Cell Leukemia is PMAIP1 (phorbol-12-myristate-13-acetate-induced protein 1), and among its related pathways are Rho Family GTPases and PEDF Induced Signaling. The compounds ccl4 and [alcl] have been mentioned in the context of this disorder. Affiliated tissues include t cells, skin and breast.

Aliases & Classifications for Adult T-Cell Leukemia

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Sources:
8Disease Ontology, 10DISEASES, 30LifeMap Discovery™, 48Orphanet, 44Novoseek, 60UMLS, 35MESH via Orphanet, 26ICD10 via Orphanet, 57SNOMED-CT via Orphanet, 61UMLS via Orphanet, 25ICD10
See all sources

Classifications:

Malacards categories (disease lists): (See all malacards categories)
Global: Cancer diseases
Anatomical: Skin diseases, Blood diseases, Immune diseases


Characteristics (Orphanet epidemiological data):

48
adult t-cell leukemia/lymphoma:
Age of onset: Adulthood


Aliases & Descriptions:

adult t-cell leukemia 8 10 30
adult t-cell leukemia/lymphoma 8 48
t cell leukemia lymphoma adult 44
adult t-cell lymphoma/leukemia 60
atll 48


External Ids:

Disease Ontology8 DOID:0050523
MESH via Orphanet35 D015459
ICD10 via Orphanet26 C91.5
SNOMED-CT via Orphanet57 110007008, 188729005, 77430005
UMLS via Orphanet61 C0023493
ICD1025 C91.5

Related Diseases for Adult T-Cell Leukemia

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Sources:
17GeneCards, 18GeneDecks
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Diseases in the Acute T Cell Leukemia family:

adult t-cell leukemia T-Cell Leukemia
Leukemia, B-Cell, Chronic Leukemia, T-Cell, Chronic
Human T-Cell Leukemia Virus Type 1 Human T-Cell Leukemia Virus Type 2
Human T-Cell Leukemia Virus Type 3

Diseases related to Adult T-Cell Leukemia via text searches within MalaCards or GeneCards/GeneDecks gene sharing:

(show top 50)    (show all 105)
idRelated DiseaseScoreTop Affiliating Genes
1t-cell leukemia32.3TXN, CCR4, TNFRSF8, HTLVR, CNTN2, CD7
2leukemia32.3TCL1A, HTLVR, CNTN2, CD7
3cutaneous t cell lymphoma31.1CCR4, CCR10, TNFRSF8
4mycosis fungoides30.7CCL22, CCR4, CCR10, TNFRSF8, CD7
5dermatitis30.7CCR10, CCR4, CCL22
6hodgkin's lymphoma30.4CCL22, CCR4, TNFRSF8, TCL1A
7rheumatoid arthritis30.2TXN, CCR4, TNFRSF8, HTLVR, CNTN2, CD7
8arthritis30.2TXN
9hepatitis b30.2MAGEA4, TNFRSF8, TXN
10severe combined immunodeficiency30.2TNFRSF8
11adult lymphoma11.4
12acute t cell leukemia10.9
13acute leukemia10.9
14hypercalcemia10.7
15tropical spastic paraparesis10.7
16adult syndrome10.6
17bone lymphoma10.5
18scabies10.5
19pneumonia10.5
20strongyloidiasis10.4
21central nervous system leukemia10.4
22t cell deficiency10.4
23graft versus host disease10.4
24lymphoid leukemia10.4
25norwegian scabies10.4
26acute pancreatitis10.4
27follicular mucinosis10.4
28anaplastic large cell lymphoma10.4
29eosinophilia10.4
30hepatitis10.4
31meningitis10.4
32myeloid leukemia10.4
33pancreatitis10.4
34retinitis10.4
35acute liver failure10.3
36colon lymphoma10.3
37central nervous system lymphoma10.3
38acute myeloid leukemia10.3
39pancytopenia10.3
40herpes simplex10.3
41monocytic leukemia10.3
42neuropathy10.3
43non-hodgkin lymphoma10.3
44erythema multiforme10.3
45papillary carcinoma10.3
46papillary thyroid carcinoma10.3
47paranasal sinus lymphoma10.1
48retinal ischemia10.1
49tracheal stenosis10.1
50thyroid lymphoma10.1

Graphical network of the top 20 diseases related to Adult T-Cell Leukemia:



Diseases related to adult t-cell leukemia

Clinical Features for Adult T-Cell Leukemia

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Drugs & Therapeutics for Adult T-Cell Leukemia

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Sources:
5CenterWatch, 41NIH Clinical Center, 6ClinicalTrials, 30LifeMap Discovery™, 60UMLS, 40NDF-RT
See all sources

Approved drugs:

Search CenterWatch for Adult T-Cell Leukemia

Drug clinical trials:

Search ClinicalTrials for Adult T-Cell Leukemia

Search NIH Clinical Center for Adult T-Cell Leukemia

Search CenterWatch for Adult T-Cell Leukemia

Cell-based therapeutics:


LifeMap Discovery
The database of embryonic development, stem cell research and regenerative medicine
Read about Adult T-Cell Leukemia cell therapies at LifeMap Discovery.
Stem-cell-based therapeutic approaches for Adult T-Cell Leukemia:
Hematopoietic stem cells for treatment of hematologic malignancies
Embryonic/Adult Cultured Cells Related to Adult T-Cell Leukemia:
Bone marrow-derived hematopoietic stem cells

Genetic Tests for Adult T-Cell Leukemia

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Anatomical Context for Adult T-Cell Leukemia

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Sources:
32MalaCards
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MalaCards organs/tissues related to Adult T-Cell Leukemia:

32
T cells, Skin, Breast, Bone, Lung, B cells, Endothelial, Liver, Myeloid, Bone marrow, Colon, Monocytes, Thyroid, Retina, Lymph node, Testis, Thymus

Animal Models for Adult T-Cell Leukemia or affiliated genes

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Publications for Adult T-Cell Leukemia

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Sources:
50PubMed
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Articles related to Adult T-Cell Leukemia:

(show top 50)    (show all 744)
idTitleAuthorsYear
1
Screening of promising chemotherapeutic candidates from plants against human adult T-cell leukemia/lymphoma (III). (23397239)
2013
2
A case of adult T-cell leukemia/lymphoma with rapid progression of pulmonary areas of ground-glass attenuation and multiple nodules. (23561258)
2013
3
Genistein induces apoptotic cell death associated with inhibition of the NF-I_B pathway in adult T-cell leukemia cells. (23526666)
2013
4
HTLV-1 bZIP factor dysregulates the Wnt pathways to support proliferation and migration of adult T-cell leukemia cells. (23045287)
2013
5
Association between decreasing trend in the mortality of adult T-cell leukemia/lymphoma and allogeneic hematopoietic stem cell transplants in Japan: analysis of Japanese vital statistics and Japan Society for Hematopoietic Cell Transplantation (JSHCT). (24241399)
2013
6
Resistant and disseminated Strongyloides stercoralis infection in a young patient with adult T-cell leukemia/lymphoma. (23323073)
2012
7
Anti-adult T-cell leukemia effects of Bidens pilosa. (21318218)
2011
8
High incidence of cytomegalovirus, human herpesvirus-6, and Epstein-Barr virus reactivation in patients receiving cytotoxic chemotherapy for adult T cell leukemia. (21328386)
2011
9
Type of skin eruption is an independent prognostic indicator for adult T-cell leukemia/lymphoma. (21325600)
2011
10
Interferon-I+ and zidovudine for relapsed/refractory adult T cell leukemia/lymphoma: case reports of Japanese patients. (21080125)
2010
11
Gene expression signatures of adult T-cell leukemia: is treatment response prediction on the horizon? (20388057)
2010
12
Aberrant expression of the transcription factor Twist in adult T-cell leukemia. (20071663)
2010
13
Testican 3 expression in adult T-cell leukemia. (19144404)
2009
14
Activation of complement system in adult T-cell leukemia (ATL) occurs mainly through lectin pathway: a serum proteomic approach using mass spectrometry. (18691810)
2008
15
Graft-versus-adult T-cell leukemia/lymphoma effect following allogeneic hematopoietic stem cell transplantation. (18332910)
2008
16
Adhesion-dependent growth of primary adult T cell leukemia cells with down-regulation of HTLV-I p40Tax protein: a novel in vitro model of the growth of acute ATL cells. (19043810)
2008
17
Allogeneic hematopoietic stem cell transplantation using reduced-intensity conditioning for adult T cell leukemia/lymphoma: impact of antithymocyte globulin on clinical outcome. (18489996)
2008
18
Influence of Epstein-Barr virus infection in adult T-cell leukemia. (18702873)
2008
19
FBXW7 mutation in adult T-cell and B-cell acute lymphocytic leukemias. (18485478)
2008
20
Detection of NOTCH1 mutations in adult T-cell leukemia/lymphoma and peripheral T-cell lymphoma. (17483057)
2007
21
Cyclin-dependent kinaselike 5 is a novel target of immunotherapy in adult T-cell leukemia. (17589290)
2007
22
HIV vector-mediated targeted suicide gene therapy for adult T-cell leukemia. (17898798)
2007
23
Inhibition of heat shock protein-90 modulates multiple functions required for survival of human T-cell leukemia virus type I-infected T-cell lines and adult T-cell leukemia cells. (17230513)
2007
24
Identification of HLA class I-restricted tumor-associated antigens in adult T cell leukemia cells by mass spectrometric analysis. (17046569)
2006
25
TCR variable gene involvement in chromosome inversion between 14q11 and 14q24 in adult T-cell leukemia. (16520872)
2006
26
Reduced frequency, diversity, and function of human T cell leukemia virus type 1-specific CD8+ T cell in adult T cell leukemia patients. (17015761)
2006
27
Adult T-cell leukemia/lymphoma in a 21-year-old man. (16630222)
2006
28
Dichotomy of all-trans retinoic acid inducing signals for adult T-cell leukemia. (15843825)
2005
29
Production of thymus and activation-regulated chemokine and macrophage-derived chemokine by CCR4+ adult T-cell leukemia cells. (15788694)
2005
30
Human T-cell leukemia virus type I (HTLV-I) infection and the onset of adult T-cell leukemia (ATL). (15854229)
2005
31
Phenotypic and functional relationship between adult T-cell leukemia cells and regulatory T cells. (15674359)
2005
32
A case of adult T-cell leukemia/lymphoma. (14758254)
2004
33
Deoxycoformycin-containing combination chemotherapy for adult T-cell leukemia-lymphoma: Japan Clinical Oncology Group Study (JCOG9109). (12627852)
2003
34
Current status of therapeutic approaches to adult T-cell leukemia. (14686487)
2003
35
Acute pancreatitis induced by diffuse pancreatic invasion of adult T-cell leukemia/lymphoma cells. (14627344)
2003
36
OX40 signaling renders adult T-cell leukemia cells resistant to Fas-induced apoptosis. (12416737)
2002
37
Adult T-cell leukemia cells over-express the multidrug-resistance-protein (MRP) and lung-resistance-protein (LRP) genes. (10404077)
1999
38
Identification of an adhesion molecule expressed on adult T cell leukemia cells derived from a patient with gastrointestinal involvement: implication for a possible role of integrin beta 7 in leukemic cell infiltration into intestinal mucosa. (10404404)
1999
39
Thiol compounds rescue growth inhibition by retinoic acid on HTLV-I (+) T lymphocytes; possible mechanism of retinoic-acid-induced growth inhibition of adult T-cell leukemia cells. (9608357)
1998
40
Constitutive chemokine production results in activation of leukocyte function-associated antigen-1 on adult T-cell leukemia cells. (9573029)
1998
41
OX40 expressed on fresh leukemic cells from adult T-cell leukemia patients mediates cell adhesion to vascular endothelial cells: implication for the possible involvement of OX40 in leukemic cell infiltration. (9108415)
1997
42
An intensive chemotherapy of adult T-cell leukemia/lymphoma: CHOP followed by etoposide, vindesine, ranimustine, and mitoxantrone with granulocyte colony-stimulating factor support. (8680890)
1996
43
Gene therapy for adult T cell leukemia using human immunodeficiency virus vector carrying the thymidine kinase gene of herpes simplex virus type 1. (8953310)
1996
44
Prevalence of human T-cell leukemia virus type 1 (HTLV-I) in family members of adult T-cell leukemia (ATL) patients in non-ATL-endemic Hokkaido of Japan. (7669948)
1995
45
Clinical significance of beta 2-microglobulin in serum of adult T cell leukemia. (7723390)
1995
46
Interleukin-4 inhibits the production of interleukin-1 by adult T-cell leukemia cells. (7628587)
1995
47
Hypercalcemia of T-cell leukemia in adults]. (8167627)
1993
48
Reactive oxygen-reducing and protein-refolding activities of adult T cell leukemia-derived factor/human thioredoxin. (1510657)
1992
49
Adult T-cell leukemia/lymphoma, histologically presenting Ki-1 positive anaplastic large cell lymphoma]. (1335094)
1992
50
Crusted (Norwegian) scabies with adult T-cell leukemia. (3874601)
1985

Genetic Variations for Adult T-Cell Leukemia

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Expression for genes affiliated with Adult T-Cell Leukemia

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Sources:
1BioGPS, 15Gene Expression Omnibus DataSets
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Expression patterns in normal tissues for genes affiliated with Adult T-Cell Leukemia

Search GEO for disease gene expression data for Adult T-Cell Leukemia.

Pathways for genes affiliated with Adult T-Cell Leukemia

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Sources:
51QIAGEN, 29KEGG, 53Reactome
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Compounds for genes affiliated with Adult T-Cell Leukemia

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Sources:
44Novoseek, 28IUPHAR, 59Tocris Bioscience
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Compounds related to Adult T-Cell Leukemia according to GeneCards/GeneDecks:

idCompoundScoreTop Affiliating Genes
1ccl444 2811.7PTHLH, CCR4, CCL22
2[alcl]4410.6TNFRSF8, CCR4
3larc4410.5CCR4, CCL22
4cyclosporin a44 28 5912.4TXN, CCL22, TNFRSF8, CNTN2

GO Terms for genes affiliated with Adult T-Cell Leukemia

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16Gene Ontology
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Biological processes related to Adult T-Cell Leukemia according to GeneCards/GeneDecks:

idNameGO IDScoreTop Affiliating Genes
1immune responseGO:00695510.7CD7, CCR10, CCR4, CCL22
2chemotaxisGO:00693510.4CCR10, CCR4, CCL22

Molecular functions related to Adult T-Cell Leukemia according to GeneCards/GeneDecks:

idNameGO IDScoreTop Affiliating Genes
1C-C chemokine receptor activityGO:01649310.6CCR10, CCR4

Products for genes affiliated with Adult T-Cell Leukemia

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Sources for Adult T-Cell Leukemia

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3CDC
13ExPASy
14FMA
22GTR
23HGMD
24HMDB
25ICD10
26ICD10 via Orphanet
27ICD9CM
28IUPHAR
29KEGG
34MeSH
35MESH via Orphanet
36MGI
39NCIt
40NDF-RT
43NINDS
44Novoseek
46OMIM
47OMIM via Orphanet
50PubMed
51QIAGEN
57SNOMED-CT via Orphanet
60UMLS
61UMLS via Orphanet