MCID: ADL037
MIFTS: 25

Adult Xanthogranuloma

Categories: Rare diseases, Skin diseases, Bone diseases, Immune diseases

Aliases & Classifications for Adult Xanthogranuloma

MalaCards integrated aliases for Adult Xanthogranuloma:

Name: Adult Xanthogranuloma 12 14 69

Classifications:



External Ids:

Disease Ontology 12 DOID:7875
NCIt 46 C27514
UMLS 69 C1332220

Summaries for Adult Xanthogranuloma

MalaCards based summary : Adult Xanthogranuloma is related to necrobiotic xanthogranuloma and cutaneous fibrous histiocytoma. An important gene associated with Adult Xanthogranuloma is CD163 (CD163 Molecule), and among its related pathways/superpathways are C-MYB transcription factor network and Hematopoietic Stem Cell Differentiation Pathways and Lineage-specific Markers. Related phenotypes are hematopoietic system and immune system

Related Diseases for Adult Xanthogranuloma

Diseases in the Adult Xanthogranuloma family:

Juvenile Xanthogranuloma

Diseases related to Adult Xanthogranuloma via text searches within MalaCards or GeneCards Suite gene sharing:

(show top 50) (show all 68)
# Related Disease Score Top Affiliating Genes
1 necrobiotic xanthogranuloma 11.0
2 cutaneous fibrous histiocytoma 10.3 CD163 HAVCR1
3 congenital granular cell tumor 10.3 LYZ SERPINA1
4 lymphoplasmacyte-rich meningioma 10.3 CD163 CD68
5 brain sarcoma 10.3 CD163 CD68
6 malignant giant cell tumor of soft parts 10.2 CD68 LYZ
7 cutaneous solitary mastocytoma 10.2 LYZ SERPINA1
8 photokeratitis 10.2 CD163 CD68
9 liver sarcoma 10.2 CD68 LYZ
10 phacolytic glaucoma 10.2 CD68 SERPINA1
11 granulomatous myositis 10.2 CD68 LYZ
12 retinitis pigmentosa 7 10.2 LYZ SERPINA1
13 inflammatory mfh 10.2 CD68 SERPINA1
14 parasitic ichthyosporea infectious disease 10.2 CD68 SERPINA1
15 rhinosporidiosis 10.2 CD68 SERPINA1
16 verruciform xanthoma of skin 10.1 CD68 S100A9
17 enterobiasis 10.1 CD163 CD68
18 nodular tenosynovitis 10.1 CD68 S100A9
19 xanthogranulomatous pyelonephritis 10.1 CD68 LYZ
20 clear cell acanthoma 10.1 CD68 HAVCR1
21 rhinoscleroma 10.1 CD68 SERPINA1
22 ulcerative stomatitis 10.1 CD68 LYZ
23 dermis tumor 10.1 CD163 HAVCR1 LYZ
24 histiocytic sarcoma 10.1 CD163 CD68
25 retinal hemangioblastoma 10.0 LYZ S100A9
26 granulomatous gastritis 10.0 CD68 FUT4
27 hodgkin's lymphoma, lymphocytic depletion 10.0 CD68 FUT4
28 nodular nonsuppurative panniculitis 10.0 LYZ SERPINA1
29 hepatitis a 10.0 HAVCR1 SERPINA1
30 central nervous system melanocytic neoplasm 10.0 CD68 S100A9
31 central nervous system sarcoma 10.0 CD163 CD68 LYZ
32 infiltrating lipoma 10.0 CD163 CD34
33 secretory meningioma 9.9 FUT4 SERPINA1
34 integumentary system benign neoplasm 9.9 CD34 HAVCR1
35 malignant epithelial mesothelioma 9.9 FUT4 S100A9
36 retina lymphoma 9.9 CD34 CD68
37 extracutaneous mastocytoma 9.9 CD34 CD68
38 glomeruloid hemangioma 9.9 CD34 CD68
39 lymphangiosarcoma 9.9 CD34 LYZ
40 hemangioma of liver 9.9 CD34 CD68
41 sarcomatoid squamous cell skin carcinoma 9.9 CD34 CD68
42 erythema elevatum diutinum 9.9 CD34 S100A9
43 in situ pulmonary adenocarcinoma 9.9 LYZ S100A9 SERPINA1
44 conventional fibrosarcoma 9.9 CD34 CD68
45 mixed liposarcoma 9.9 CD34 CD68
46 ischemic fasciitis 9.9 CD34 CD68
47 xanthogranulomatous cholecystitis 9.8 CD68 LYZ S100A9
48 chorioangioma 9.8 CD34 FUT4
49 urinary system disease 9.8 HAVCR1 LYZ
50 clear cell ependymoma 9.7 CD34 CD68

Graphical network of the top 20 diseases related to Adult Xanthogranuloma:



Diseases related to Adult Xanthogranuloma

Symptoms & Phenotypes for Adult Xanthogranuloma

MGI Mouse Phenotypes related to Adult Xanthogranuloma:

43
# Description MGI Source Accession Score Top Affiliating Genes
1 hematopoietic system MP:0005397 9.43 CD163 CD34 CD68 FUT4 LYZ S100A9
2 immune system MP:0005387 9.1 CD163 CD34 CD68 FUT4 LYZ S100A9

Drugs & Therapeutics for Adult Xanthogranuloma

Search Clinical Trials , NIH Clinical Center for Adult Xanthogranuloma

Genetic Tests for Adult Xanthogranuloma

Anatomical Context for Adult Xanthogranuloma

Publications for Adult Xanthogranuloma

Articles related to Adult Xanthogranuloma:

(show all 13)
# Title Authors Year
1
Adult xanthogranuloma diagnosed on reflectance confocal microscopy. ( 28671710 )
2017
2
Multiple CD163(+) adult xanthogranuloma associated with myelodysplastic syndrome. ( 26249658 )
2015
3
Adult Xanthogranuloma, Reticulohistiocytosis, and Rosai-Dorfman Disease. ( 26143426 )
2015
4
Unusual presentation of adult xanthogranuloma: a case report. ( 24154556 )
2013
5
CD163+ adult xanthogranuloma arising from Merkel cell carcinoma treated with local radiotherapy. ( 22504842 )
2012
6
Adult xanthogranuloma mimicking basal cell carcinoma: dermoscopy, reflectance confocal microscopy and pathological correlation. ( 19996569 )
2010
7
Adult xanthogranuloma causing nasal obstruction. ( 20479384 )
2010
8
Multiple adult xanthogranuloma in intertriginous areas. ( 19335696 )
2009
9
Multiple adult xanthogranuloma: case report and literature review. ( 16319479 )
2006
10
Ossifying adult xanthogranuloma. ( 14521441 )
2003
11
Adult xanthogranuloma of the vulva: case report and review. ( 11902455 )
2002
12
Juvenile and adult xanthogranuloma. A histological and immunohistochemical comparison. ( 8291651 )
1994
13
Solitary adult xanthogranuloma: a case report with new observation on lipid droplet formation. ( 6162331 )
1980

Variations for Adult Xanthogranuloma

Expression for Adult Xanthogranuloma

Search GEO for disease gene expression data for Adult Xanthogranuloma.

Pathways for Adult Xanthogranuloma

Pathways related to Adult Xanthogranuloma according to GeneCards Suite gene sharing:

# Super pathways Score Top Affiliating Genes
1 11.05 CD34 LYZ
2 10.86 CD163 CD34 CD68
3 10.82 CD163 CD34

GO Terms for Adult Xanthogranuloma

Cellular components related to Adult Xanthogranuloma according to GeneCards Suite gene sharing:

# Name GO ID Score Top Affiliating Genes
1 cell periphery GO:0071944 8.62 CD34 FUT4

Biological processes related to Adult Xanthogranuloma according to GeneCards Suite gene sharing:

# Name GO ID Score Top Affiliating Genes
1 inflammatory response GO:0006954 9.43 CD163 LYZ S100A9
2 antimicrobial humoral response GO:0019730 9.16 LYZ S100A9
3 acute-phase response GO:0006953 8.96 CD163 SERPINA1
4 neutrophil degranulation GO:0043312 8.92 CD68 LYZ S100A9 SERPINA1

Sources for Adult Xanthogranuloma

3 CDC
7 CNVD
9 Cosmic
10 dbSNP
11 DGIdb
16 ExPASy
18 FMA
27 GO
28 GTR
29 HGMD
30 HMDB
31 HPO
32 ICD10
33 ICD10 via Orphanet
34 ICD9CM
35 IUPHAR
36 KEGG
37 LifeMap
39 MedGen
41 MeSH
42 MESH via Orphanet
43 MGI
45 NCI
46 NCIt
47 NDF-RT
50 NINDS
51 Novoseek
53 OMIM
54 OMIM via Orphanet
58 PubMed
60 QIAGEN
65 SNOMED-CT via HPO
66 SNOMED-CT via Orphanet
67 TGDB
68 Tocris
69 UMLS
70 UMLS via Orphanet
Content
Loading form....