MCID: AFB001
MIFTS: 49

Afibrinogenemia

Categories: Rare diseases, Blood diseases, Genetic diseases

Aliases & Classifications for Afibrinogenemia

MalaCards integrated aliases for Afibrinogenemia:

Name: Afibrinogenemia 49 36 28 51 69
Congenital Hypofibrinogenemia 69
Congenital Afibrinogenemia 49
Afibrinogenemia Congenital 49

Classifications:



External Ids:

KEGG 36 H00222
UMLS 69 C2584774

Summaries for Afibrinogenemia

NIH Rare Diseases : 49 Afibrinogenemia, sometimes called congenital afibrinogenemia, is an inheritedblood disorder in which the blood does not clot normally. It occurs when there is a lack (deficiency) of a protein called fibrinogen (or coagulation factor I), which is needed for the blood to clot. Affected individuals may be susceptible to severe bleeding (hemorrhaging) episodes, particularly during infancy and childhood. Afibrinogenemia is thought to be transmitted as an autosomal recessivetrait. Treatment may include cryoprecipitate (a blood product containing concentrated fibrinogen and other clotting factors), fibrinogen (RiaSTAP) or plasma (the liquid portion of the blood which contains clotting factors).  Last updated: 5/30/2016

MalaCards based summary : Afibrinogenemia, also known as congenital hypofibrinogenemia, is related to afibrinogenemia, congenital and dysfibrinogenemia, congenital. An important gene associated with Afibrinogenemia is CFI (Complement Factor I), and among its related pathways/superpathways are Complement and coagulation cascades and Response to elevated platelet cytosolic Ca2+. The drugs Hemostatics and Complement Factor I have been mentioned in the context of this disorder. Affiliated tissues include placenta, heart and liver, and related phenotypes are cardiovascular system and homeostasis/metabolism

Related Diseases for Afibrinogenemia

Diseases in the Afibrinogenemia family:

Afibrinogenemia, Congenital

Diseases related to Afibrinogenemia via text searches within MalaCards or GeneCards Suite gene sharing:

(show top 50) (show all 145)
# Related Disease Score Top Affiliating Genes
1 afibrinogenemia, congenital 32.1 C3 CFI F2 F3 F8 FGA
2 dysfibrinogenemia, congenital 32.0 FGA FGB FGG
3 spinal cord infarction 29.8 F2 F5
4 purpura 29.4 F2 F3 VWF
5 thrombotic thrombocytopenic purpura 29.3 CD46 F3 VWF
6 hemophilia 29.0 F2 F3 F8 VWF
7 dysfibrinogenemia 28.9 F2 F5 FGA FGB FGG
8 thrombosis 28.5 F10 F2 F3 F5 VWF
9 pulmonary embolism 28.4 F10 F2 F3 F5
10 von willebrand's disease 28.1 F11 F2 F3 F5 F8 VWF
11 thrombophilia due to thrombin defect 27.7 F10 F2 F3 F5 F8 VWF
12 myocardial infarction 26.6 F10 F11 F2 F3 F5 F8
13 hypofibrinogenemia, familial 10.9
14 chronic thromboembolic pulmonary hypertension 10.5 FGA FGB
15 c3 glomerulopathy 10.4 C3 CFP
16 chronic monocytic leukemia 10.4 C3 F2
17 complement factor h deficiency 10.4 CD46 CFI
18 thyroid crisis 10.3 CR1 F8
19 complement component 3 deficiency 10.3 C3 CFI CFP
20 fainting 10.3 F8 VWF
21 vitamin k deficiency hemorrhagic disease 10.3 F2 F8
22 variola minor 10.3 CD46 CR1
23 von willebrand disease, type 2 10.3 F8 VWF
24 cerebral falx meningioma 10.2 F2 F3
25 von willebrand disease, type 3 10.2 F8 VWF
26 cerebral arteritis 10.2 F8 VWF
27 intestinal impaction 10.2 F2 F3
28 giant hemangioma 10.2 F2 F3
29 dysbaric osteonecrosis 10.2 C3 F3
30 active peptic ulcer disease 10.2 F2 VWF
31 enterocolitis 10.2 C3 CD46 CFI
32 blue toe syndrome 10.2 F2 F3
33 cardiac tamponade 10.2 F2 F8
34 intracranial embolism 10.2 F2 F3
35 femoral neuropathy 10.2 F2 F3
36 neisseria meningitidis infection 10.1 C3 CD46 CFP
37 membranoproliferative glomerulonephritis 10.1 C3 CD46 CFP
38 hantavirus pulmonary syndrome 10.1 F2 F3
39 complement hyperactivation, angiopathic thrombosis, and protein-losing enteropathy 10.1
40 lemierre's syndrome 10.1 C3 F11 F3
41 anterior cranial fossa meningioma 10.1 F2 F3
42 acquired von willebrand syndrome 10.1 F11 F8 VWF
43 ascending cholangitis 10.1 C3 F2
44 marantic endocarditis 10.1 F2 F3
45 acquired angioedema 10.1 C3 F5
46 heparin-induced thrombocytopenia 10.0 F10 F3
47 fournier gangrene 10.0 F2 F3 F8
48 paracetamol poisoning 10.0 F2 F5
49 splenic disease 10.0 F2 F3
50 complement factor i deficiency 10.0 C3 CFI CFP CR1

Graphical network of the top 20 diseases related to Afibrinogenemia:



Diseases related to Afibrinogenemia

Symptoms & Phenotypes for Afibrinogenemia

MGI Mouse Phenotypes related to Afibrinogenemia:

43
# Description MGI Source Accession Score Top Affiliating Genes
1 cardiovascular system MP:0005385 10.22 F3 CD46 F5 CFP F10 FGA
2 homeostasis/metabolism MP:0005376 10.1 F3 CFI F5 CFP F8 F10
3 hematopoietic system MP:0005397 10.02 C3 F3 CFI F8 F11 FGA
4 mortality/aging MP:0010768 9.93 C3 F3 F5 CFP F8 F10
5 immune system MP:0005387 9.91 F2 C3 F3 CFP F8 F11
6 nervous system MP:0003631 9.61 F2 C3 CD46 F3 F5 F11
7 reproductive system MP:0005389 9.23 C3 CD46 F8 F10 FGA F2

Drugs & Therapeutics for Afibrinogenemia

Drugs for Afibrinogenemia (from DrugBank, HMDB, Dgidb, PharmGKB, IUPHAR, NovoSeek, BitterDB):


# Name Status Phase Clinical Trials Cas Number PubChem Id
1 Hemostatics Phase 3,Phase 2
2 Complement Factor I

Interventional clinical trials:

(show all 12)

# Name Status NCT ID Phase Drugs
1 Human Fibrinogen Concentrate in Pediatric Cardiac Surgery Recruiting NCT02822599 Phase 4 RiaStAP;Saline
2 Human Fibrinogen Concentrate (FGTW) in Pediatric Patients With Congenital Fibrinogen Deficiency Completed NCT02094430 Phase 2, Phase 3 biological: human fibrinogen concentrate
3 Haemocomplettan® P During Elective Complex Cardiac Surgery Completed NCT01124981 Phase 2, Phase 3 Haemocomplettan® P;Human albumin (Placebo)
4 Pharmacokinetic, Efficacy and Safety of BT524 in Patients With Congenital Fibrinogen Deficiency Recruiting NCT02065882 Phase 3
5 Study to Assess the Efficacy, Safety and Pharmacokinetic of Octafibrin in Paediatric Subjects With Fibrinogen Deficiency Recruiting NCT02408484 Phase 3
6 Efficacy and Safety Study of Octafibrin for On-demand Treatment of Acute Bleeding and to Prevent Bleeding During and After Surgery Recruiting NCT02267226 Phase 3 Octafibrin
7 Fibrinogen Concentrate (Human) − Efficacy and Safety Study Withdrawn NCT00916656 Phase 3
8 Pharmacokinetic, Efficacy, and Safety Study of Octafibrin Compared to Haemocomplettan/Riastap Completed NCT01575756 Phase 2
9 Human Fibrinogen - Pharmacokinetics Completed NCT00496262 Phase 2
10 Pharmacokinetics, Efficacy, and Safety of Human Plasma-Derived Fibrinogen (FIB Grifols) in Patients With Congenital Afibrinogenaemia Recruiting NCT02281500 Phase 1, Phase 2
11 RiaSTAP vs. Conventional Transfusion in Patients Having Heart Valve Surgery Terminated NCT01283321 Phase 2 Human fibrinogen concentrate
12 An Observational Cohort Study of the Safety and Efficacy of Fibrinogen Concentrate, Human (FCH) in Subjects With Congenital Fibrinogen Deficiency Completed NCT02427217

Search NIH Clinical Center for Afibrinogenemia

Inferred drug relations via UMLS 69 / NDF-RT 47 :


Genetic Tests for Afibrinogenemia

Genetic tests related to Afibrinogenemia:

# Genetic test Affiliating Genes
1 Afibrinogenemia 28 CFI

Anatomical Context for Afibrinogenemia

MalaCards organs/tissues related to Afibrinogenemia:

38
Placenta, Heart, Liver, Prostate, Spinal Cord, Bone, Uterus

Publications for Afibrinogenemia

Articles related to Afibrinogenemia:

(show top 50) (show all 239)
# Title Authors Year
1
Successful delivery in an patient with afibrinogenemia after three abortions: A case report and review of the literature. ( 29388741 )
2018
2
Identification of novel mutations in congenital afibrinogenemia patients and molecular modeling of missense mutations in Pakistani population. ( 28912669 )
2017
3
Afibrinogenemia Acquired by Liver Transplant. ( 28952920 )
2017
4
Post-authorization safety study of Clottafact(Ar) , a triply secured fibrinogen concentrate in congenital afibrinogenemia. A prospective observational study. ( 27583698 )
2016
5
Congenital afibrinogenemia: from etiopathogenesis to challenging clinical management. ( 27291795 )
2016
6
Congenital afibrinogenemia: a case report of a spontaneous hepatic hematoma. ( 27428204 )
2016
7
A Rare Complication Of Congenital Afibrinogenemia: Bone Cysts. ( 27094883 )
2016
8
Fibrinogen Martin: A Novel Mutation in FGB (Gln180Stop) Causing Congenital Afibrinogenemia. ( 27148845 )
2016
9
Perioperative Coagulation Management in a Patient with Congenital Afibrinogenemia during Revision Total Hip Arthroplasty. ( 27472424 )
2016
10
A novel missense mutation in the FGB gene (p.Gly302Arg) leading to afibrinogenemia. Predicted structure and function consequences. ( 27824214 )
2016
11
Severe Thrombotic Complications in Congenital Afibrinogenemia: A Pathophysiological and Management Dilemma. ( 27253088 )
2016
12
Congenital afibrinogenemia: Identification and characterization of two novel homozygous fibrinogen AI+ and BI^ chain mutations in two Tunisian families. ( 27164460 )
2016
13
Thrombosis of abdominal aorta in congenital afibrinogenemia: case report and review of literature. ( 25421938 )
2015
14
Venous thrombosis in afibrinogenemia: a successful use of rivaroxaban. ( 26036982 )
2015
15
Paradoxical bleeding and thrombosis in a patient with afibrinogenemia and fibrinogen mumbai mutation. ( 25873512 )
2015
16
Resolution of fibrinogen deficiency in a patient with congenital afibrinogenemia after liver transplantation. ( 26421965 )
2015
17
Novel Fibrinogen Bbeta Chain Mutation as an Underlying Mechanism of Afibrinogenemia? ( 26485721 )
2015
18
Umbilical bleeding: a presenting feature for congenital afibrinogenemia. ( 26407137 )
2015
19
Yes or no for secondary prophylaxis in afibrinogenemia? ( 26484644 )
2015
20
Recurrent massive haemoperitoneum associated with ruptured corpus luteum in women with congenital afibrinogenemia; case report. ( 28913028 )
2014
21
Spontaneous epidural and subdural hematoma in a child with afibrinogenemia and postoperative management. ( 24509337 )
2014
22
Recurrent myocardial infarction in a case of congenital afibrinogenemia. ( 24949183 )
2014
23
A case of congenital afibrinogenemia complicated with thromboembolic events that required repeated amputations. ( 25255238 )
2014
24
Targeted mutation of zebrafish fga models human congenital afibrinogenemia. ( 24553182 )
2014
25
Spontaneous splenic rupture in a patient with congenital afibrinogenemia. ( 26078670 )
2014
26
Congenital afibrinogenemia in a new born: a rare cause for bleeding. ( 24509333 )
2014
27
Treatment of afibrinogenemia in a chihuahua. ( 23148136 )
2013
28
Novel homozygous fibrinogen AI+ chain truncation causes severe afibrinogenemia with life threatening complications in a two-year-old boy. ( 24050829 )
2013
29
Percutaneous coronary intervention in a case of afibrinogenemia. ( 24570509 )
2013
30
Pulmonary embolism in a patient with congenital afibrinogenemia. ( 23855372 )
2013
31
Successful ABO-incompatible kidney transplantation in patient with congenital afibrinogenemia. ( 22624802 )
2012
32
Diagnosis and non-surgical periodontal management in congenital afibrinogenemia: report of a rare case. ( 22323341 )
2012
33
Mutation of the translation initiation codon in FGA causes congenital afibrinogenemia. ( 22732251 )
2012
34
Recurrent massive hemoperitoneum due to ovulation as a clinical sign in congenital afibrinogenemia. ( 21241266 )
2011
35
A novel frameshift mutation in FGA (c.1846 del A) leading to congenital afibrinogenemia in a consanguineous Syrian family. ( 21245743 )
2011
36
Thrombotic and hemorrhagic presentation of congenital hypo/afibrinogenemia. ( 20870369 )
2011
37
Anaesthetic management of a child with congenital afibrinogenemia - A rare inherited coagulation disorder. ( 22223906 )
2011
38
Chronic subdural hematoma in a patient with congenital afibrinogenemia successfully treated with fibrinogen replacement. ( 22123482 )
2011
39
Cellulitis on face in a patient with congenital afibrinogenemia. ( 21521918 )
2011
40
Successive bleeding and thrombotic complications in a patient with afibrinogenemia: a case report. ( 21496887 )
2011
41
Identification and functional characterization of a novel nonsense mutation in FGA accounting for congenital afibrinogenemia in six Egyptian patients. ( 20051841 )
2010
42
Is primary prophylaxis required in afibrinogenemia? ( 20598104 )
2010
43
Severe elbow arthropathy in a patient with congenital afibrinogenemia: a case report. ( 20124074 )
2010
44
Congenital Afibrinogenemia presenting as antenatal intracranial bleed: a case report. ( 20180944 )
2010
45
Spontaneous intracranial bleeding in a neonate with congenital afibrinogenemia. ( 20445442 )
2010
46
Spinal cord infarction in congenital afibrinogenemia: a case report and review of the literature. ( 19560685 )
2009
47
A novel frameshift mutation in FGA accounting for congenital afibrinogenemia predicted to encode an aberrant peptide terminating 158 amino acids downstream. ( 19417632 )
2009
48
Severe spontaneous arterial thrombotic manifestations in patients with inherited hypo- and afibrinogenemia. ( 19335753 )
2009
49
[Genetic analysis of an inherited afibrinogenemia family caused by a novel frameshift mutation in FGA]. ( 19698251 )
2009
50
A deep intronic mutation in FGB creates a consensus exonic splicing enhancer motif that results in afibrinogenemia caused by aberrant mRNA splicing, which can be corrected in vitro with antisense oligonucleotide treatment. ( 18853456 )
2009

Variations for Afibrinogenemia

ClinVar genetic disease variations for Afibrinogenemia:

6 (show all 18)
# Gene Variation Type Significance SNP ID Assembly Location
1 CFI NM_000204.4(CFI): c.1253A> T (p.His418Leu) single nucleotide variant Pathogenic rs121964912 GRCh37 Chromosome 4, 110667554: 110667554
2 CFI CFI, IVS5DS G-A, -1 single nucleotide variant Pathogenic
3 CFI CFI, 2-BP INS, 1205AT insertion Pathogenic
4 CFI NM_000204.4(CFI): c.728G> A (p.Gly243Asp) single nucleotide variant Pathogenic rs121964916 GRCh37 Chromosome 4, 110681723: 110681723
5 FGG NM_021870.2(FGG): c.78+5G> A single nucleotide variant Pathogenic rs587776837 GRCh38 Chromosome 4, 154612527: 154612527
6 FGG NM_021870.2(FGG): c.307+5G> A single nucleotide variant Pathogenic rs587776838 GRCh37 Chromosome 4, 155533165: 155533165
7 FGG NM_021870.2(FGG): c.667-320A> T single nucleotide variant Pathogenic rs587776839 GRCh38 Chromosome 4, 154608970: 154608970
8 FGB NM_005141.4(FGB): c.1148T> G (p.Leu383Arg) single nucleotide variant Pathogenic rs121909621 GRCh37 Chromosome 4, 155490855: 155490855
9 FGB NM_005141.4(FGB): c.1289G> A (p.Gly430Asp) single nucleotide variant Pathogenic rs121909622 GRCh37 Chromosome 4, 155491615: 155491615
10 FGB NM_005141.4(FGB): c.958+13C> T single nucleotide variant Pathogenic rs606231223 GRCh38 Chromosome 4, 154569320: 154569320
11 FGB NM_005141.4(FGB): c.1244+1G> T single nucleotide variant Pathogenic rs606231224 GRCh38 Chromosome 4, 154569800: 154569800
12 FGB NM_005141.4(FGB): c.605T> A (p.Leu202Gln) single nucleotide variant Pathogenic rs121909624 GRCh37 Chromosome 4, 155488859: 155488859
13 FGB NM_005141.4(FGB): c.139C> T (p.Arg47Ter) single nucleotide variant Pathogenic rs121909625 GRCh37 Chromosome 4, 155486984: 155486984
14 FGA NC_000004.12 deletion Pathogenic GRCh38 Chromosome 4, 154580323: 154590216
15 FGA NM_000508.4(FGA): c.510+1G> T single nucleotide variant Pathogenic rs146387238 GRCh37 Chromosome 4, 155508663: 155508663
16 FGA NM_000508.4(FGA): c.711dupT (p.Lys238Terfs) duplication Pathogenic rs606231225 GRCh38 Chromosome 4, 154586718: 154586718
17 CFI NM_000204.4(CFI): c.80_81delAT (p.Asp27Alafs) deletion Pathogenic rs886043418 GRCh37 Chromosome 4, 110687957: 110687958
18 FGA NM_000508.4(FGA): c.502C> T (p.Arg168Ter) single nucleotide variant Pathogenic rs755117226 GRCh37 Chromosome 4, 155508672: 155508672

Expression for Afibrinogenemia

Search GEO for disease gene expression data for Afibrinogenemia.

Pathways for Afibrinogenemia

Pathways related to Afibrinogenemia according to KEGG:

36
# Name Kegg Source Accession
1 Complement and coagulation cascades hsa04610

Pathways related to Afibrinogenemia according to GeneCards Suite gene sharing:

(show all 16)
# Super pathways Score Top Affiliating Genes
1
Show member pathways
13.1 F10 F11 F2 F3 F5 F8
2
Show member pathways
12.53 F10 F11 F2 F3 F5 F8
3
Show member pathways
12.16 FGA FGB FGG VWF
4
Show member pathways
11.99 FGA FGB FGG VWF
5
Show member pathways
11.96 C3 CD46 CFI CR1
6 11.94 C3 CD46 CFI CR1 F10 F11
7
Show member pathways
11.93 C3 CD46 CFI CFP CR1
8
Show member pathways
11.91 FGA FGB FGG VWF
9 11.85 FGA FGB FGG VWF
10
Show member pathways
11.76 C3 CD46 CFP CR1
11
Show member pathways
11.76 F2 FGA FGB FGG VWF
12
Show member pathways
11.52 F10 F11 F2 F3 F5 F8
13 11.46 C3 CFI FGG
14 11.39 FGA FGB FGG
15 11.36 F2 FGA FGB FGG VWF
16 10.73 F10 F2

GO Terms for Afibrinogenemia

Cellular components related to Afibrinogenemia according to GeneCards Suite gene sharing:

(show all 14)
# Name GO ID Score Top Affiliating Genes
1 cell surface GO:0009986 9.93 CD46 CR1 F3 FGA FGB FGG
2 external side of plasma membrane GO:0009897 9.83 F2 FGA FGB FGG
3 blood microparticle GO:0072562 9.83 C3 F2 FGA FGB FGG
4 endoplasmic reticulum lumen GO:0005788 9.76 C3 CFP F10 F2 F5 F8
5 extracellular vesicle GO:1903561 9.69 F5 FGA FGB
6 fibrinogen complex GO:0005577 9.58 FGA FGB FGG
7 COPII-coated ER to Golgi transport vesicle GO:0030134 9.54 F5 F8
8 intrinsic component of external side of plasma membrane GO:0031233 9.48 F10 F3
9 platelet alpha granule lumen GO:0031093 9.43 F5 F8 FGA FGB FGG VWF
10 platelet alpha granule GO:0031091 9.02 F5 FGA FGB FGG VWF
11 plasma membrane GO:0005886 10.27 C3 CD46 CR1 F10 F11 F2
12 extracellular exosome GO:0070062 10.15 C3 CD46 CFI CR1 F11 F2
13 extracellular region GO:0005576 10.07 C3 CFI CFP F10 F11 F2
14 extracellular space GO:0005615 10.06 C3 CFI CFP F11 F2 F3

Biological processes related to Afibrinogenemia according to GeneCards Suite gene sharing:

(show all 37)
# Name GO ID Score Top Affiliating Genes
1 post-translational protein modification GO:0043687 9.96 C3 F5 FGA FGG
2 extracellular matrix organization GO:0030198 9.94 FGA FGB FGG VWF
3 cellular protein metabolic process GO:0044267 9.93 C3 F2 F5 FGA FGG
4 ER to Golgi vesicle-mediated transport GO:0006888 9.92 F10 F2 F5 F8
5 complement activation, classical pathway GO:0006958 9.9 C3 CD46 CFI CR1
6 platelet degranulation GO:0002576 9.88 F5 F8 FGA FGB FGG VWF
7 platelet activation GO:0030168 9.85 F2 F8 FGA FGB FGG VWF
8 cell-matrix adhesion GO:0007160 9.83 FGA FGB FGG
9 response to calcium ion GO:0051592 9.81 FGA FGB FGG
10 regulation of complement activation GO:0030449 9.8 C3 CD46 CFI CFP CR1 F2
11 toll-like receptor signaling pathway GO:0002224 9.79 FGA FGB FGG
12 platelet aggregation GO:0070527 9.79 FGA FGB FGG
13 positive regulation of protein secretion GO:0050714 9.78 FGA FGB FGG
14 negative regulation of extrinsic apoptotic signaling pathway via death domain receptors GO:1902042 9.77 FGA FGB FGG
15 positive regulation of substrate adhesion-dependent cell spreading GO:1900026 9.76 FGA FGB FGG
16 positive regulation of vasoconstriction GO:0045907 9.75 FGA FGB FGG
17 negative regulation of endothelial cell apoptotic process GO:2000352 9.74 FGA FGB FGG
18 positive regulation of exocytosis GO:0045921 9.73 FGA FGB FGG
19 fibrinolysis GO:0042730 9.73 F2 FGA FGB FGG
20 cellular protein complex assembly GO:0043623 9.72 FGA FGB FGG
21 protein polymerization GO:0051258 9.7 FGA FGB FGG
22 positive regulation of heterotypic cell-cell adhesion GO:0034116 9.69 FGA FGB FGG
23 regulation of blood coagulation GO:0030193 9.67 F11 F2
24 signal peptide processing GO:0006465 9.67 F10 F2
25 positive regulation of peptide hormone secretion GO:0090277 9.67 FGA FGB FGG
26 complement activation, alternative pathway GO:0006957 9.66 C3 CFP
27 peptidyl-glutamic acid carboxylation GO:0017187 9.65 F10 F2
28 blood coagulation GO:0007596 9.65 F10 F11 F2 F3 F5 F8
29 induction of bacterial agglutination GO:0043152 9.64 FGA FGB
30 blood coagulation, extrinsic pathway GO:0007598 9.63 F10 F3
31 blood coagulation, fibrin clot formation GO:0072378 9.63 FGA FGB FGG
32 plasminogen activation GO:0031639 9.56 F11 FGA FGB FGG
33 blood coagulation, intrinsic pathway GO:0007597 9.55 F10 F11 F2 F8 VWF
34 hemostasis GO:0007599 9.32 F10 F11 F2 F3 F5 F8
35 proteolysis GO:0006508 10.07 C3 CFI F10 F11 F2
36 immune system process GO:0002376 10.04 C3 CD46 CR1 FGA FGB
37 innate immune response GO:0045087 10.02 C3 CD46 CFI CFP CR1 FGA

Molecular functions related to Afibrinogenemia according to GeneCards Suite gene sharing:

# Name GO ID Score Top Affiliating Genes
1 receptor binding GO:0005102 9.55 C3 F2 FGA FGB FGG
2 protein binding, bridging GO:0030674 9.54 FGA FGB FGG
3 cell adhesion molecule binding GO:0050839 9.5 FGA FGB FGG
4 serine-type peptidase activity GO:0008236 9.26 CFI F10 F11 F2
5 serine-type endopeptidase activity GO:0004252 9.1 C3 CFI F10 F11 F2 F3
6 protein binding GO:0005515 10.13 C3 CD46 CFI CFP F10 F11

Sources for Afibrinogenemia

3 CDC
7 CNVD
9 Cosmic
10 dbSNP
11 DGIdb
16 ExPASy
18 FMA
27 GO
28 GTR
29 HGMD
30 HMDB
31 HPO
32 ICD10
33 ICD10 via Orphanet
34 ICD9CM
35 IUPHAR
36 KEGG
37 LifeMap
39 MedGen
41 MeSH
42 MESH via Orphanet
43 MGI
45 NCI
46 NCIt
47 NDF-RT
50 NINDS
51 Novoseek
53 OMIM
54 OMIM via Orphanet
58 PubMed
60 QIAGEN
65 SNOMED-CT via HPO
66 SNOMED-CT via Orphanet
67 TGDB
68 Tocris
69 UMLS
70 UMLS via Orphanet
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