MCID: AFR002
MIFTS: 49

African Tick-Bite Fever malady

Infectious diseases category

Summaries for African Tick-Bite Fever

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Disease Ontology:9 A spotted fever that has material basis in rickettsia africae, which is transmitted by ticks (amblyomma hebraeum and amblyomma variegatum). the infection has symptom fever, has symptom eschar and has symptom maculopapular rash.

MalaCards based summary: African Tick-Bite Fever, also known as south african tick-bite fever, is related to boutonneuse fever and cutaneous leishmaniasis, and has symptoms including fever, eschar and maculopapular rash. An important gene associated with African Tick-Bite Fever is CCL5 (chemokine (C-C motif) ligand 5), and among its related pathways are Cell adhesion Cell matrix glycoconjugates and Chemokine Superfamily: Human/Mouse Ligand-Receptor Interactions. The compounds mycophenolic acid and mcp 1 have been mentioned in the context of this disorder. Affiliated tissues include skin and endothelial, and related mouse phenotypes are respiratory system and no phenotypic analysis.

Wikipedia:64 African tick bite fever is a bacterial infection transmitted by the Amblyomma, Dermacentor or the... more...

Aliases & Classifications for African Tick-Bite Fever

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African Tick-Bite Fever, Aliases & Descriptions:

Name: African Tick-Bite Fever 9 11
South African Tick-Bite Fever 9 61
 
Rickettsia Africae Spotted Fever 9
African Tick Bite Fever 61


Classifications:

Malacards categories (disease lists): (See all malacards categories)
Global: Infectious diseases


External Ids:

Disease Ontology9 DOID:0050035

Related Diseases for African Tick-Bite Fever

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Diseases related to African Tick-Bite Fever via text searches within MalaCards or GeneCards/GeneDecks gene sharing:

(show top 50)    (show all 102)
idRelated DiseaseScoreTop Affiliating Genes
1boutonneuse fever31.7MTCP1
2cutaneous leishmaniasis30.8IL10, IFNG
3leishmaniasis30.6IL10, IFNG, IL13
4spotted fever10.5
5typhus10.5
6filariasis10.5IL13
7pustulosis palmaris et plantaris10.4SELE
8internuclear ophthalmoplegia10.4
9queensland tick typhus10.4
10cellulitis10.4
11exanthem10.4
12neuropathy10.4
13ophthalmoplegia10.4
14endotheliitis10.4
15mediterranean spotted fever10.4
16eosinophilic pneumonia10.3IL13, CCL5
17vernal keratoconjunctivitis10.3CCL5, IL13
18periapical granuloma10.3CCL5, CCL3
19encephalitis10.3CCL3, CCL5
20systemic mastocytosis10.3CCL5, CCL3
21respiratory failure10.3CCL5, IL13
22alcoholic hepatitis10.2CCL5, CCL3
23psoriatic arthritis10.2SELE, IL13
24pulmonary eosinophilia10.2CCL3, IL13
25extrinsic allergic alveolitis10.2CCL5, CCL3
26bullous pemphigoid10.2IL13, CCL5
27dengue disease10.2CCL3, CCL5
28rhinitis10.2IL13, CCL5
29interstitial lung disease10.2CCL3, CCL5
30pleural tuberculosis10.2IFNG, CCL3
31tropical spastic paraparesis10.2IFNG, CCL3
32aspergillosis10.2IFNG, CCL3
33tuberculoid leprosy10.2IL10, IFNG
34behcet's disease10.2SELE, CCL3
35lepromatous leprosy10.2IL10, IFNG
36toxic shock syndrome10.2CCL3, IFNG
37visceral leishmaniasis10.2IFNG, IL10
38acute graft versus host disease10.1IFNG, IL10
39type 1 diabetes mellitus10.1IL10, IFNG
40bronchiolitis10.1IL13, CCL3, CCL5
41lupus nephritis10.1IL10, CCL5
42chronic obstructive pulmonary disease10.1CCL3, IL13, CCL5
43peripheral vascular disease10.1SELE, VWF
44thrombotic thrombocytopenic purpura, acquired10.1VWF, SELE
45hepatitis b10.1IL10, IFNG
46cutaneous t cell lymphoma10.1SELE, IFNG
47dermatitis10.1IFNG, SELE, IL13
48lymphopenia10.1IFNG, IL10
49pulmonary sarcoidosis10.1CCL5, IFNG, CCL3
50myasthenia gravis10.1IFNG, IL10

Graphical network of the top 20 diseases related to African Tick-Bite Fever:



Diseases related to african tick-bite fever

Symptoms for African Tick-Bite Fever

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Symptoms:

 9
  • fever
  • eschar
  • maculopapular rash

Drugs & Therapeutics for African Tick-Bite Fever

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Drug clinical trials:

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Genetic Tests for African Tick-Bite Fever

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Anatomical Context for African Tick-Bite Fever

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MalaCards organs/tissues related to African Tick-Bite Fever:

32
Skin, Endothelial

Animal Models for African Tick-Bite Fever or affiliated genes

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MGI Mouse Phenotypes related to African Tick-Bite Fever:

36
idDescriptionMGI Source AccessionScoreTop Affiliating Genes
1MP:00053888.6IL13, IL10, IFNG, SELE
2MP:00030128.2VWF, IFNG, IL10, IL13
3MP:00053818.1VWF, CCL3, IFNG, IL10, IL13
4MP:00053847.6VWF, SELE, CCL3, IFNG, IL10, IL13
5MP:00053767.6VWF, SELE, CCL3, IFNG, IL10, IL13
6MP:00107687.5VWF, SELE, CCL3, IFNG, IL10, IL13
7MP:00053977.4IL13, VWF, SELE, CCL3, CCL5, IFNG
8MP:00053877.4VWF, SELE, CCL3, CCL5, IFNG, IL10

Publications for African Tick-Bite Fever

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Articles related to African Tick-Bite Fever:

(show all 44)
idTitleAuthorsYear
1
Case report of African tick-bite fever from Poland. (24494003)
2013
2
The use of eschar swabs for the diagnosis of African tick-bite fever. (23141102)
2012
3
Cutaneous leishmaniasis and rickettsial African tick-bite fever: a combination of exotic traveler's diseases in the same patient. (22788813)
2012
4
Neurological picture. Internuclear ophthalmoplegia following African tick bite fever. (21421770)
2011
5
Risk factors for African tick-bite fever in rural central Africa. (21460018)
2011
6
African tick-bite fever: a new entity in the differential diagnosis of multiple eschars in travelers. Description of five cases imported from South Africa to Switzerland. (20233665)
2010
7
Relative chemokine and adhesion molecule expression in Mediterranean spotted fever and African tick bite fever. (19091423)
2009
8
Unusual location of an inoculation lesion in a traveler with African tick-bite fever returning from South Africa. (19930389)
2009
9
Tache noire in African tick bite fever. (19861601)
2009
10
Diagnosis of Queensland tick typhus and African tick bite fever by PCR of lesion swabs. (19523304)
2009
11
African tick bite Fever in a Taiwanese traveler returning from South Africa: molecular and serologic studies. (19861602)
2009
12
African tick bite fever in elderly patients: 8 cases in French tourists returning from South Africa. (18558881)
2008
13
African tick bite fever--papulovesicular exanthem with fever after staying in South Africa. (18021248)
2008
14
African tick bite fever. (18218581)
2008
15
Two cases of cellulitis in the course of African tick bite fever: a fortuitous association? (18503259)
2008
16
African tick bite fever in a returned traveler. (17939635)
2007
17
African tick bite fever. (17067925)
2006
18
African tick bite fever: a not-so-uncommon illness in international travelers. (17043186)
2006
19
Histologic features and immunodetection of African tick-bite fever eschar. (17073080)
2006
20
Sub-acute neuropathy in patients with African tick bite fever. (16449002)
2006
21
Increased levels of soluble CD40L in African tick bite fever: possible involvement of TLRs in the pathogenic interaction between Rickettsia africae, endothelial cells, and platelets. (16888032)
2006
22
Cardiac involvement in a patient with clinical and serological evidence of African tick-bite fever. (16242016)
2005
23
African tick-bite fever in French travelers. (16422013)
2005
24
African tick-bite fever. (15301327)
2004
25
Comparison of immunofluorescence, Western blotting, and cross-adsorption assays for diagnosis of African tick bite fever. (15242958)
2004
26
African tick-bite fever: four cases among Swiss travelers returning from South Africa. (15541225)
2004
27
African tick bite fever in travelers to rural sub-Equatorial Africa. (12766836)
2003
28
Sequential changes in hematologic and biochemical parameters in African tick bite fever. (12925109)
2003
29
African tick bite fever: not a spotless rickettsiosis! (12582376)
2003
30
Systemic inflammatory responses in African tick-bite fever. (12696016)
2003
31
African tick bite fever. (12954562)
2003
32
Outbreak of African tick-bite fever in six Italian tourists returning from South Africa. (11939395)
2002
33
African tick-bite fever in South Africa. (12379945)
2002
34
Imported African tick bite fever: a case report. (10344666)
1999
35
African tick-bite fever imported into Norway: presentation of 8 cases. (10447320)
1999
36
African tick-bite fever among international travelers--Oregon, 1998. (9832471)
1998
37
African tick-bite fever. An imported spotless rickettsiosis. (8996049)
1997
38
African Tick-Bite Fever: A Case Report. (9815517)
1997
39
Rickettsia africae sp. nov., the etiological agent of African tick bite fever. (8934912)
1996
40
South African tick-bite fever complicated by severe encephalopathy. (1598654)
1992
41
African tick-bite fever: a new spotted fever group rickettsiosis under an old name. (1357393)
1992
42
Correlation of the distribution of Rickettsia conorii, microscopic lesions, and clinical features in South African tick bite fever. (3885774)
1985
43
South African tick-bite fever (1931-1981). (7036374)
1981
44
A method for increasing the infectivity of yolk-sac cultures of the rickettsiae of epidemic and murine typhus, and South African tick-bite fever. (20282007)
1946

Variations for African Tick-Bite Fever

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Expression for genes affiliated with African Tick-Bite Fever

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Expression patterns in normal tissues for genes affiliated with African Tick-Bite Fever

Search GEO for disease gene expression data for African Tick-Bite Fever.

Pathways for genes affiliated with African Tick-Bite Fever

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Pathways related to African Tick-Bite Fever according to GeneCards/GeneDecks:

(show all 24)
idSuper pathways (with members indented)ScoreTop Affiliating Genes
19.7CCL5, SELE
2
Show member pathways
9.6CCL5, CCL3
39.5IFNG, IL13
49.4IFNG, SELE
59.4CCL3, VWF
6
Show member pathways
IL27-mediated signaling events37
9.4IL10, IFNG
7
Show member pathways
9.1CCL5, IFNG, IL13
89.1IL13, IFNG, SELE
9
Show member pathways
9.0IFNG, IL10, IL13
10
Show member pathways
9.0IL13, IL10, IFNG
119.0IL13, IL10, IFNG
12
Show member pathways
Type III interferon signaling37
9.0IL13, IL10, IFNG
139.0IL13, IL10, IFNG
149.0IL13, IL10, IFNG
159.0IL10, IFNG, SELE
169.0IL10, IFNG, SELE
179.0CCL3, CCL5, IFNG
18
Show member pathways
8.9CCL3, IFNG, IL10
19
Show member pathways
8.8CCL3, CCL5, IL10, IL13
20
Show member pathways
8.8CCL3, CCL5, IL10, IL13
21
Show member pathways
8.8CCL3, CCL5, IL10, IL13
22
Show member pathways
Toll-like receptor signaling pathway37
Regulation of toll-like receptor signaling pathway37
8.5CCL3, CCL5, IFNG, IL10
23
Show member pathways
8.2CCL3, CCL5, IFNG, IL10, IL13
24
Show member pathways
8.2IL13, IL10, IFNG, CCL5, CCL3

Compounds for genes affiliated with African Tick-Bite Fever

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Compounds related to African Tick-Bite Fever according to GeneCards/GeneDecks:

(show top 50)    (show all 141)
idCompoundScoreTop Affiliating Genes
1mycophenolic acid44 50 1211.6IL13, SELE, CCL5
2mcp 1449.5CCL3, CCL5, IL10
3mdms449.5CCL3, CCL5, IL10
4amphotericin b449.4IL13, IFNG, CCL5
5alpha-galactosylceramide449.4IL13, IFNG, IL10
6il-12449.3IL10, IFNG, IL13
7indoleamine449.3IFNG, IL13, IL10
8mip 1alpha449.2IL10, IL13, CCL3, CCL5
9polymyxin b449.2IL10, IFNG, SELE
10okt3449.1IL10, IFNG, SELE
11fluticasone propionate44 50 60 1212.1CCL5, IL13, IFNG, SELE
12glatiramer acetate44 1210.1IL10, CCL5, IL13, IFNG
13lipoteichoic acid449.1CCL3, IL10, SELE
14indinavir44 50 1211.1CCL5, CCL3, IFNG
15thalidomide44 50 60 1212.0IL13, IL10, IFNG, CCL5
16homocysteine44 2510.0VWF, SELE, CCL3, CCL5
17triptolide449.0CCL3, CCL5, IFNG
18rolipram44 60 2911.0IFNG, IL10, IL13, SELE
19pdtc448.9CCL5, CCL3, SELE, IFNG
20calcitriol44 60 25 1211.9IL10, IFNG, CCL5, IL13
21polyinosinic-polycytidylic acid448.9SELE, IL10, CCL3, IFNG
22budesonide44 50 1210.8IL13, CCL5, IFNG
23groalpha448.8IL13, SELE, CCL3, CCL5, IL10
24aspirin44 50 29 2511.7SELE, VWF, IL13, CCL5
25ly294002448.7SELE, CCL5, CCL3, IL13, IL10
26guanine44 25 1210.7IL10, SELE, VWF, CCL3
27lactate448.6CCL3, CCL5, IL13, SELE, VWF
28gm-csf44 299.6IFNG, IL10, CCL5, IL13, CCL3
29il 10448.6IL13, CCL3, IL10, IFNG, CCL5
30tarc448.6IL10, IFNG, IL13, CCL5, CCL3
31cyclophosphamide44 50 1210.6IL13, CCL3, IL10, SELE, VWF
32ccl344 299.6CCL5, CCL3, IFNG, IL10, IL13
33hydrocortisone44 3 60 1211.6CCL5, IFNG, IL10, CCL3, IL13
34heparin44 29 25 1211.6IL13, SELE, VWF, CCL3, CCL5
35ionomycin448.6CCL3, CCL5, IFNG, IL10, IL13
36tacrolimus44 50 1210.5IL13, IL10, IFNG, CCL5, CCL3
37aspartate448.5IL10, VWF, SELE, CCL3, IL13
38prednisolone44 29 1210.4VWF, CCL3, IFNG, IL10, IL13
39endotoxin448.2CCL5, CCL3, IFNG, IL10, IL13, SELE
40rantes448.2SELE, CCL5, IL13, IL10, IFNG, CCL3
41sb 20358044 609.2SELE, CCL5, IFNG, IL10, IL13, CCL3
42pge2448.1IL10, SELE, CCL3, IL13, CCL5, IFNG
43cycloheximide448.1SELE, IL10, IFNG, CCL5, CCL3, IL13
44simvastatin44 50 60 29 25 1213.0IL10, VWF, SELE, CCL3, CCL5, IFNG
45cyclosporin a44 29 6010.0CCL5, IFNG, CCL3, VWF, IL10, IL13
46dexamethasone44 50 29 1211.0IL13, IL10, IFNG, CCL5, CCL3, VWF
47histamine44 29 259.7VWF, SELE, CCL3, CCL5, IFNG, IL10
48vegf447.6IL13, CCL3, VWF, SELE, CCL5, IFNG
49nitric oxide44 25 129.6IL13, VWF, SELE, CCL3, IFNG, CCL5
50cysteine447.6VWF, CCL3, CCL5, IL13, MTCP1, IFNG

GO Terms for genes affiliated with African Tick-Bite Fever

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Cellular components related to African Tick-Bite Fever according to GeneCards/GeneDecks:

idNameGO IDScoreTop Affiliating Genes
1external side of plasma membraneGO:0098979.0IL13, IFNG, VWF
2extracellular regionGO:0055767.8VWF, CCL3, CCL5, IFNG, IL13
3extracellular spaceGO:0056157.6IL13, IL10, IFNG, CCL5, CCL3, SELE

Biological processes related to African Tick-Bite Fever according to GeneCards/GeneDecks:

(show all 32)
idNameGO IDScoreTop Affiliating Genes
1leukocyte cell-cell adhesionGO:00715910.0SELE, CCL5
2positive regulation of natural killer cell chemotaxisGO:200050310.0CCL5, CCL3
3eosinophil chemotaxisGO:04824510.0CCL5, CCL3
4negative regulation by host of viral transcriptionGO:04392210.0CCL3, CCL5
5macrophage chemotaxisGO:04824610.0CCL5, CCL3
6monocyte chemotaxisGO:00254810.0CCL3, CCL5
7positive regulation of smooth muscle cell proliferationGO:04866110.0CCL5, IL13
8cellular response to interferon-gammaGO:07134610.0CCL3, CCL5
9positive regulation of calcium ion transportGO:0519289.9CCL5, CCL3
10positive chemotaxisGO:0509189.9CCL3, CCL5
11lipopolysaccharide-mediated signaling pathwayGO:0316639.9CCL5, CCL3
12protein kinase B signalingGO:0434919.9CCL5, CCL3
13cellular response to interleukin-1GO:0713479.9CCL5, CCL3
14cellular response to organic cyclic compoundGO:0714079.9CCL3, CCL5
15regulation of sensory perception of painGO:0519309.8IL10, CCL3
16positive regulation of MHC class II biosynthetic processGO:0453489.8IL10, IFNG
17calcium-mediated signalingGO:0197229.8CCL3, SELE
18negative regulation of growth of symbiont in hostGO:0441309.8IL10, IFNG
19positive regulation of cell adhesionGO:0457859.8IFNG, CCL5
20cellular response to tumor necrosis factorGO:0713569.8CCL5, CCL3
21response to toxic substanceGO:0096369.7CCL5, CCL3
22positive regulation of interleukin-1 beta secretionGO:0507189.7CCL3, IFNG
23positive regulation of T cell proliferationGO:0421029.7IFNG, CCL5
24MAPK cascadeGO:0001659.7CCL3, CCL5
25cellular calcium ion homeostasisGO:0068749.6CCL5, CCL3
26positive regulation of tumor necrosis factor productionGO:0327609.6IFNG, CCL3
27neutrophil chemotaxisGO:0305939.6CCL3, IFNG
28calcium ion transportGO:0068169.5CCL5, CCL3
29cellular response to lipopolysaccharideGO:0712229.4IL10, IFNG
30exocytosisGO:0068879.3CCL5, CCL3
31cell-cell signalingGO:0072679.2CCL3, CCL5, IL10, IL13
32inflammatory responseGO:0069548.8IL13, IL10, CCL5, CCL3, SELE

Molecular functions related to African Tick-Bite Fever according to GeneCards/GeneDecks:

idNameGO IDScoreTop Affiliating Genes
1phospholipase activator activityGO:0160049.7CCL5, CCL3
2CCR1 chemokine receptor bindingGO:0317269.7CCL5, CCL3
3CCR5 chemokine receptor bindingGO:0317309.6CCL5, CCL3
4chemokine activityGO:0080099.6CCL5, CCL3
5chemoattractant activityGO:0420569.3CCL5, CCL3
6cytokine activityGO:0051258.9IFNG, IL10, IL13

Products for genes affiliated with African Tick-Bite Fever

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Sources for African Tick-Bite Fever

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26ICD10
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