MCID: AFR002
MIFTS: 31

African Tick-Bite Fever malady

Infectious diseases category

Aliases & Classifications for African Tick-Bite Fever

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Aliases & Descriptions for African Tick-Bite Fever:

Name: African Tick-Bite Fever 10 12
Rickettsia Africae Spotted Fever 10
 
South African Tick-Bite Fever 10
African Tick Bite Fever 65


Classifications:



External Ids:

Disease Ontology10 DOID:0050035

Summaries for African Tick-Bite Fever

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Disease Ontology:10 A spotted fever that has material basis in rickettsia africae, which is transmitted by ticks (amblyomma hebraeum and amblyomma variegatum). the infection has symptom fever, has symptom eschar and has symptom maculopapular rash.

MalaCards based summary: African Tick-Bite Fever, also known as rickettsia africae spotted fever, is related to boutonneuse fever and spotted fever, and has symptoms including fever, eschar and maculopapular rash. An important gene associated with African Tick-Bite Fever is CD40LG (CD40 Ligand), and among its related pathways are Inflammatory Response Pathway and Calcineurin-regulated NFAT-dependent transcription in lymphocytes. Affiliated tissues include endothelial, and related mouse phenotypes are integument and hematopoietic system.

Related Diseases for African Tick-Bite Fever

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Diseases related to African Tick-Bite Fever via text searches within MalaCards or GeneCards Suite gene sharing:

(show top 50)    (show all 124)
idRelated DiseaseScoreTop Affiliating Genes
1boutonneuse fever10.5
2spotted fever10.5
3typhus10.5
4cutaneous leishmaniasis10.4
5queensland tick typhus10.4
6internuclear ophthalmoplegia10.4
7cellulitis10.4
8exanthem10.4
9leishmaniasis10.4
10neuropathy10.4
11ophthalmoplegia10.4
12encephalopathy10.4
13endotheliitis10.4
14mediterranean spotted fever10.4
15scleroderma10.2IFNG, SELE
16benign deep fibrous histiocytoma10.2CCL5, IFNG
17fasciolopsiasis10.2IFNG, SELE
18pulmonary valve agenesis - fallot's tetralogy - absence of ductus arteriosus10.2CCL5, IFNG
19chronic demyelinizing neuropathy with igm monoclonal10.2IFNG, SELE
20sternum cancer10.2CCL5, IFNG
21polyradiculopathy10.1CCL5, IFNG
22visceral heterotaxy10.1CCL5, IFNG
23basal ganglia cerebrovascular disease10.1IFNG, IL13
24neuroendocrine tumor10.1CCL5, IFNG
25neonatal urinary tract infectious disease10.1IFNG, IL13
26alopecia areata10.1IFNG, SELE
27focal chorioretinitis10.1CCL5, IFNG
28branchiootorenal syndrome10.1IFNG, IL13
29paraphilia disorder10.1IFNG, IL13
30conventional central osteosarcoma10.1IFNG, SELE
31congenital cataract - progressive muscular hypotonia - hearing loss - developmental delay10.1IL13, SELE
32chronic cystitis10.1CCL5, IL13
33allergic contact dermatitis10.1IFNG, IL13
34verrucous nevus acanthokeratolytic10.1CCL5, IL13
35intermediate dend syndrome10.1CCL5, IL13
36prostate small cell carcinoma10.1IL13, SELE
37acute poststreptococcal glomerulonephritis10.1IFNG, SELE
38ependymoblastoma10.1CCL5, IL13
39pulmonary large cell neuroendocrine carcinoma10.1CCL5, IL13
40tuberculosis10.1CCL5, IFNG
41hypotrichosis of eyelid10.1CCL5, IL13
42foramen magnum meningioma10.1IFNG, IL13
43connective tissue benign neoplasm10.1IFNG, IL13
44brachial plexus neuritis10.1CCL5, IFNG
45degenerative disc disease10.1IFNG, IL13
46chronic congestive splenomegaly10.1CCL5, IL13
47xeroderma of eyelid10.1IFNG, IL13
48ileum cancer10.0IFNG, IL13
49glucocorticoid-induced osteoporosis10.0CD40LG, IFNG
50melas syndrome10.0CD40LG, IFNG

Graphical network of the top 20 diseases related to African Tick-Bite Fever:



Diseases related to african tick-bite fever

Symptoms for African Tick-Bite Fever

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Symptoms:

 10
  • fever
  • eschar
  • maculopapular rash

Drugs & Therapeutics for African Tick-Bite Fever

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Interventional clinical trials:

Search ClinicalTrials, NIH Clinical Center for African Tick-Bite Fever

Genetic Tests for African Tick-Bite Fever

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Anatomical Context for African Tick-Bite Fever

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MalaCards organs/tissues related to African Tick-Bite Fever:

33
Endothelial

Animal Models for African Tick-Bite Fever or affiliated genes

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MGI Mouse Phenotypes related to African Tick-Bite Fever:

38
idDescriptionMGI Source AccessionScoreTop Affiliating Genes
1MP:00107718.0CD40LG, IFNG, IL13, SELE
2MP:00053977.5CCL5, CD40LG, IFNG, IL13, SELE
3MP:00053877.2CCL5, CD40LG, IFNG, IL13, SELE

Publications for African Tick-Bite Fever

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Articles related to African Tick-Bite Fever:

(show all 47)
idTitleAuthorsYear
1
First case of imported African tick-bite fever in Poland - Case report. (26403104)
2015
2
Images in clinical medicine: African tick-bite fever after a game-hunting expedition. (25738687)
2015
3
African Tick-Bite Fever in a Returning Traveler. (25795527)
2015
4
A family with African tick bite fever. (25886872)
2015
5
Case report of African tick-bite fever from Poland. (24494003)
2013
6
Cutaneous leishmaniasis and rickettsial African tick-bite fever: a combination of exotic traveler's diseases in the same patient. (22788813)
2012
7
Neurological picture. Internuclear ophthalmoplegia following African tick bite fever. (21421770)
2011
8
Risk factors for African tick-bite fever in rural central Africa. (21460018)
2011
9
African tick-bite fever: a new entity in the differential diagnosis of multiple eschars in travelers. Description of five cases imported from South Africa to Switzerland. (20233665)
2010
10
Relative chemokine and adhesion molecule expression in Mediterranean spotted fever and African tick bite fever. (19091423)
2009
11
Unusual location of an inoculation lesion in a traveler with African tick-bite fever returning from South Africa. (19930389)
2009
12
Tache noire in African tick bite fever. (19861601)
2009
13
Diagnosis of Queensland tick typhus and African tick bite fever by PCR of lesion swabs. (19523304)
2009
14
African tick bite Fever in a Taiwanese traveler returning from South Africa: molecular and serologic studies. (19861602)
2009
15
African tick bite fever in elderly patients: 8 cases in French tourists returning from South Africa. (18558881)
2008
16
African tick bite fever--papulovesicular exanthem with fever after staying in South Africa. (18021248)
2008
17
African tick bite fever. (18218581)
2008
18
Two cases of cellulitis in the course of African tick bite fever: a fortuitous association? (18503259)
2008
19
African tick bite fever in a returned traveler. (17939635)
2007
20
African tick bite fever. (17067925)
2006
21
African tick bite fever: a not-so-uncommon illness in international travelers. (17043186)
2006
22
Histologic features and immunodetection of African tick-bite fever eschar. (17073080)
2006
23
Sub-acute neuropathy in patients with African tick bite fever. (16449002)
2006
24
Increased levels of soluble CD40L in African tick bite fever: possible involvement of TLRs in the pathogenic interaction between Rickettsia africae, endothelial cells, and platelets. (16888032)
2006
25
Cardiac involvement in a patient with clinical and serological evidence of African tick-bite fever. (16242016)
2005
26
African tick-bite fever in French travelers. (16422013)
2005
27
African tick-bite fever. (15301327)
2004
28
Comparison of immunofluorescence, Western blotting, and cross-adsorption assays for diagnosis of African tick bite fever. (15242958)
2004
29
African tick-bite fever: four cases among Swiss travelers returning from South Africa. (15541225)
2004
30
African tick bite fever in travelers to rural sub-Equatorial Africa. (12766836)
2003
31
Sequential changes in hematologic and biochemical parameters in African tick bite fever. (12925109)
2003
32
African tick bite fever: not a spotless rickettsiosis! (12582376)
2003
33
Systemic inflammatory responses in African tick-bite fever. (12696016)
2003
34
African tick bite fever. (12954562)
2003
35
Outbreak of African tick-bite fever in six Italian tourists returning from South Africa. (11939395)
2002
36
African tick-bite fever in South Africa. (12379945)
2002
37
Imported African tick bite fever: a case report. (10344666)
1999
38
African tick-bite fever imported into Norway: presentation of 8 cases. (10447320)
1999
39
African tick-bite fever among international travelers--Oregon, 1998. (9832471)
1998
40
African tick-bite fever. An imported spotless rickettsiosis. (8996049)
1997
41
African Tick-Bite Fever: A Case Report. (9815517)
1997
42
Rickettsia africae sp. nov., the etiological agent of African tick bite fever. (8934912)
1996
43
South African tick-bite fever complicated by severe encephalopathy. (1598654)
1992
44
African tick-bite fever: a new spotted fever group rickettsiosis under an old name. (1357393)
1992
45
Correlation of the distribution of Rickettsia conorii, microscopic lesions, and clinical features in South African tick bite fever. (3885774)
1985
46
South African tick-bite fever (1931-1981). (7036374)
1981
47
A method for increasing the infectivity of yolk-sac cultures of the rickettsiae of epidemic and murine typhus, and South African tick-bite fever. (20282007)
1946

Variations for African Tick-Bite Fever

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Expression for genes affiliated with African Tick-Bite Fever

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Search GEO for disease gene expression data for African Tick-Bite Fever.

Pathways for genes affiliated with African Tick-Bite Fever

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GO Terms for genes affiliated with African Tick-Bite Fever

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Cellular components related to African Tick-Bite Fever according to GeneCards Suite gene sharing:

idNameGO IDScoreTop Affiliating Genes
1external side of plasma membraneGO:00098979.0CD40LG, IFNG, IL13
2extracellular spaceGO:00056157.5CCL5, CD40LG, IFNG, IL13, SELE

Biological processes related to African Tick-Bite Fever according to GeneCards Suite gene sharing:

(show all 19)
idNameGO IDScoreTop Affiliating Genes
1positive regulation of interleukin-12 productionGO:003273510.0CD40LG, IFNG
2regulation of insulin secretionGO:00507969.9CCL5, IFNG
3positive regulation of osteoclast differentiationGO:00456729.9CCL5, IFNG
4cellular response to lipopolysaccharideGO:00712229.8CCL5, IFNG
5response to tumor necrosis factorGO:00346129.8CCL5, SELE
6neutrophil chemotaxisGO:00305939.7CCL5, IFNG
7positive regulation of cell adhesionGO:00457859.7CCL5, IFNG
8negative regulation of neuron deathGO:19012159.6CCL5, IL13
9positive regulation of T cell proliferationGO:00421029.5CCL5, IFNG
10response to virusGO:00096159.5CCL5, IFNG
11positive regulation of smooth muscle cell proliferationGO:00486619.4CCL5, IL13
12positive regulation of neuron differentiationGO:00456669.4CCL5, IFNG
13cellular response to cytokine stimulusGO:00713459.4CCL5, IL13
14leukocyte cell-cell adhesionGO:00071599.4CCL5, CD40LG, SELE
15movement of cell or subcellular componentGO:00069289.3IFNG, IL13
16response to cytokineGO:00340979.0CCL5, SELE
17response to lipopolysaccharideGO:00324968.9CCL5, IL13, SELE
18immune responseGO:00069558.4CCL5, CD40LG, IFNG, IL13
19inflammatory responseGO:00069548.4CCL5, CD40LG, IL13, SELE

Molecular functions related to African Tick-Bite Fever according to GeneCards Suite gene sharing:

idNameGO IDScoreTop Affiliating Genes
1cytokine activityGO:00051258.7CD40LG, IFNG, IL13

Sources for African Tick-Bite Fever

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2CDC
14ExPASy
15FDA
16FMA
24GTR
25HGMD
26HMDB
27ICD10
28ICD10 via Orphanet
29ICD9CM
30IUPHAR
31KEGG
34MedGen
36MeSH
37MESH via Orphanet
38MGI
41NCI
42NCIt
43NDF-RT
46NINDS
47Novoseek
49OMIM
50OMIM via Orphanet
54PubMed
55QIAGEN
60SNOMED-CT via Orphanet
64Tumor Gene Family of Databases
65UMLS
66UMLS via Orphanet