MCID: AFR002
MIFTS: 42

African Tick-Bite Fever malady

Category: Infectious diseases

Aliases & Classifications for African Tick-Bite Fever

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Aliases & Descriptions for African Tick-Bite Fever:

Name: African Tick-Bite Fever 10 12
Rickettsia Africae Spotted Fever 10
 
South African Tick-Bite Fever 10
African Tick Bite Fever 65

Classifications:



External Ids:

Disease Ontology10 DOID:0050035
UMLS65 C1320317

Summaries for African Tick-Bite Fever

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Disease Ontology:10 A spotted fever that has material basis in Rickettsia africae, which is transmitted by ticks (Amblyomma hebraeum and Amblyomma variegatum). The infection has symptom fever, has symptom eschar and has symptom maculopapular rash.

MalaCards based summary: African Tick-Bite Fever, also known as rickettsia africae spotted fever, is related to asthma and boutonneuse fever, and has symptoms including fever, eschar and maculopapular rash. An important gene associated with African Tick-Bite Fever is CD40LG (CD40 Ligand), and among its related pathways are Th2 Differentiation Pathway and OX40 Pathway. Affiliated tissues include skin, bone and thyroid, and related mouse phenotypes are respiratory system and reproductive system.

Wikipedia:68 African tick bite fever is a bacterial infection transmitted by the Amblyomma, Dermacentor or the... more...

Related Diseases for African Tick-Bite Fever

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Diseases related to African Tick-Bite Fever via text searches within MalaCards or GeneCards Suite gene sharing:

(show top 50)    (show all 188)
idRelated DiseaseScoreTop Affiliating Genes
1asthma29.5CCL3, CCL5, CD40LG, CXCL8, IFNG, IL10
2boutonneuse fever12.3
3beriberi10.5CD40LG, IFNG
4oropouche fever10.5CD40LG, IL10
5cycloplegia10.5IFNG, IL10
6proliferative glomerulonephritis10.5CD40LG, CXCL8
7bacillary angiomatosis10.5CD40LG, IFNG
8louping ill10.5CD40LG, IFNG, IL10
9b cell deficiency10.4CD40LG, IFNG, IL10
10cow milk allergy10.4IFNG, IL10, IL13
11cervix melanoma10.4CD40LG, GPT, IFNG
12blastomycosis10.4CD40LG, IFNG, IL10
13vernal conjunctivitis10.4CD40LG, IFNG, IL10
14idiopathic cd4-positive t-lymphocytopenia10.4IL10, IL13
15primary progressive multiple sclerosis10.4CD40LG, IFNG, IL10
16hodgkin's lymphoma, nodular sclerosis10.4CD40LG, IL10, IL13
17dysgammaglobulinemia10.4CD40LG, IL10
18wissler's syndrome10.4IFNG, IL10, IL13
19food allergy10.4IFNG, IL10, SELE
20limited scleroderma10.4CD40LG, IFNG, IL10
21peritoneal cystic mesothelioma10.4CXCL8, IFNG, IL10
22peripheral retinal degeneration10.4CXCL8, IFNG, IL10
23blackwater fever10.4IFNG, IL10, SELE
24temporal lobe epilepsy10.4CD40LG, IFNG, SELE
25pneumocystosis10.3CD40LG, IFNG, IL10
26hydronephrosis10.3CCL5, IFNG, IL10
27narcissistic personality disorder10.3CD40LG, CXCL8, TLR4
28blue toe syndrome10.3CD40LG, CXCL8, TLR4
29lymph node cancer10.3TLR2, TLR4
30vagus nerve neoplasm10.3CD40LG, IFNG, IL10, SELE
31uterine corpus epithelioid leiomyoma10.3CD40LG, IFNG, IL10, IL13
32aniseikonia10.3CD40LG, IL10, TLR2
33liver lipoma10.3CXCL8, IFNG, IL10
34hemorrhagic proctocolitis10.3CD40LG, GPT, IFNG, IL10
35orbital plasma cell granuloma10.3CCL5, IFNG, IL13
36abdominal tuberculosis10.3IFNG, IL10, TLR2
37tethered spinal cord syndrome10.3IFNG, IL10, TLR2
38lateral sclerosis10.3CD40LG, IL10, TLR2
39rumination disorder10.3CD40LG, TLR2, TLR4
40capillary hemangioma10.3CD40LG, IFNG, IL13, SELE
41schizophrenia10.3
42neuroblastoma10.3
43colorectal cancer10.3
44attention deficit-hyperactivity disorder10.3
45nasopharyngeal carcinoma10.3
46pancreatic cancer10.3
47acute lymphocytic leukemia10.3
48crohn's disease10.3
49holoprosencephaly10.3
50leukemia10.3

Graphical network of the top 20 diseases related to African Tick-Bite Fever:



Diseases related to african tick-bite fever

Symptoms for African Tick-Bite Fever

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Symptoms:

 10
  • fever
  • eschar
  • maculopapular rash

Drugs & Therapeutics for African Tick-Bite Fever

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Interventional clinical trials:

Search ClinicalTrials, NIH Clinical Center for African Tick-Bite Fever

Genetic Tests for African Tick-Bite Fever

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Anatomical Context for African Tick-Bite Fever

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MalaCards organs/tissues related to African Tick-Bite Fever:

33
Skin, Bone, Thyroid, Bone marrow, Colon, T cells

Animal Models for African Tick-Bite Fever or affiliated genes

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MGI Mouse Phenotypes related to African Tick-Bite Fever:

38
idDescriptionMGI Source AccessionScoreTop Affiliating Genes
1MP:00053888.8IFNG, IL10, IL13, SELE, THBD, TLR2
2MP:00053897.9CD40LG, GGT1, IFNG, IL10, IL13, IL15
3MP:00107717.8CD40LG, GGT1, IFNG, IL10, IL13, SELE
4MP:00053857.1ADRA2A, CD40LG, CX3CL1, IFNG, IL10, IL15
5MP:00053766.8ADRA2A, CD40LG, CX3CL1, GGT1, IFNG, IL10
6MP:00053975.8CCL5, CD40LG, CX3CL1, GGT1, GPT, IFNG
7MP:00053875.8CCL5, CD40LG, CX3CL1, GGT1, IFNG, IL10

Publications for African Tick-Bite Fever

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Articles related to African Tick-Bite Fever:

(show all 48)
idTitleAuthorsYear
1
Novel AAV-based rat model of forebrain synucleinopathy shows extensive pathologies and progressive loss of cholinergic interneurons. (24999658)
2014
2
Evaluation of autologous blood clot subsegmental pulmonary thromboembolism in minimally invasive experimental canine model. (24020405)
2013
3
Beyond the gowers sign: measuring outcomes in Duchenne muscular dystrophy. (24038058)
2013
4
Transmission network of an HIV type 1 strain with K103N in young Belgian patients from different risk groups. (23731270)
2013
5
CTLA-4 gene polymorphism at position +49 A>G in exon 1: a risk factor for cervical cancer in Indian women. (23830732)
2013
6
4-O-methylhonokiol inhibits colon tumor growth via p21-mediated suppression of NF-I_B activity. (21820300)
2012
7
Activation of stress response gene SIRT1 by BCR-ABL promotes leukemogenesis. (22207735)
2012
8
Identification and characterization of anti-platelet antibodies in idiopathic thrombocytopenic purpura patients. (23113135)
2012
9
Immune reconstitution--the footing of Chinese medicine treatment for acquired immunodeficiency syndrome. (21611894)
2011
10
Polymerase chain reaction confirmation of Babesia canis canis and Anaplasma phagocytophilum in dogs suspected of babesiosis in Slovakia. (21736486)
2011
11
Avian influenza and Newcastle disease in three risk areas for H5N1 highly pathogenic avian influenza in Mali, 2007-2008. (22312986)
2011
12
Residential pesticides and childhood leukemia: a systematic review and meta-analysis. (21519680)
2011
13
Differential effects of Paclitaxel on dendritic cell function. (20302610)
2010
14
The MIF homologue D-dopachrome tautomerase promotes COX-2 expression through I^-catenin-dependent and -independent mechanisms. (21071513)
2010
15
Thyroid hormone receptor beta gene mutation (P453A) in a family producing resistance to thyroid hormone. (18561095)
2009
16
Immunohistochemical similarities between pancreatic mucinous cystic tumor and ovarian mucinous cystic tumor. (18192871)
2008
17
The management of desmoids in patients with familial adenomatous polyposis (FAP). (19069698)
2008
18
Case 1: An unusual cause of headaches and priapism in a teenager. (19337598)
2008
19
Influence of H pylori on plasma ghrelin in patients without atrophic gastritis. (17461454)
2007
20
Functional lentiviral vectors for xeroderma pigmentosum gene therapy. (16857285)
2006
21
Cirp protects against tumor necrosis factor-alpha-induced apoptosis via activation of extracellular signal-regulated kinase. (16569452)
2006
22
A population-based case-control study of isolated primary congenital glaucoma. (16652361)
2006
23
Human primary co-culture angiogenesis assay reveals additive stimulation and different angiogenic properties of VEGF and HGF. (15149635)
2004
24
Milk-induced urticaria is associated with the expansion of T cells expressing cutaneous lymphocyte antigen. (11941320)
2002
25
Failure to replicate an allelic association between an exon 8 polymorphism of the human alpha(1A) calcium channel gene and common syndromes of idiopathic generalized epilepsy. (12049805)
2002
26
A role for protein phosphatase 2A-like activity, but not atypical protein kinase Czeta, in the inhibition of protein kinase B/Akt and glycogen synthesis by palmitate. (11574400)
2001
27
Simulation studies of St. Louis encephalitis virus in south Florida. (12653129)
2001
28
Peptide hormones versus steroid hormones: case studies from snail and turtle populations. (11795397)
2001
29
Three-dimensional crystal structure of human eosinophil cationic protein (RNase 3) at 1.75 A resolution. (10903870)
2000
30
Estradiol formation by human osteoblasts via multiple pathways: relation with osteoblast function. (10536374)
1999
31
Superoxide dismutase-mimicking activities of dinuclear Cu(II) complexes with ligands containing a tetrathioether-tetraamino moiety. (9414487)
1998
32
Duraflo II coating of cardiopulmonary bypass circuits reduces complement activation, but does not affect the release of granulocyte enzymes : a European multicentre study. (9080162)
1997
33
Stress-signalling kinase Sek1 protects thymocytes from apoptosis mediated by CD95 and CD3. (9002521)
1997
34
Association between common alleles of the low-density lipoprotein receptor gene region and interindividual variation in plasma lipid and apolipoprotein levels in a population-based sample from Rochester, Minnesota. (9003506)
1997
35
The "common stem cell" hypothesis reevaluated: human fetal bone marrow contains separate populations of hematopoietic and stromal progenitors. (7537114)
1995
36
Selective inhibition of the mitochondrial permeability transition pore at the oxidation-reduction sensitive dithiol by monobromobimane. (7536690)
1995
37
The Drosophila sex determination gene snf encodes a nuclear protein with sequence and functional similarity to the mammalian U1A snRNP protein. (7926776)
1994
38
Cranial epidural fibrous tumor associated with hyperostosis: a case report. (8235976)
1993
39
CHOP, a novel developmentally regulated nuclear protein that dimerizes with transcription factors C/EBP and LAP and functions as a dominant-negative inhibitor of gene transcription. (1547942)
1992
40
Investigations on macromolecular precipitation inhibitors of calcium oxalate. (1736490)
1992
41
Basement membranes in adenoid cystic carcinoma. An immunohistochemical study. (1315206)
1992
42
The fat lady enters stage left. Acute selenium poisoning. (2274074)
1990
43
Human KGF is FGF-related with properties of a paracrine effector of epithelial cell growth. (2475908)
1989
44
On treating the older patient with multiple personality disorder: "race against time" or "make haste slowly"? (3364389)
1988
45
Hematologic dysfunction in Lassa fever. (3183637)
1988
46
Neonatal meningitis caused by Haemophilus influenzae type c. (6975976)
1981
47
Dissecting aortic aneurysm diagnosed by echocardiography in a patient with rupture of the aneurysm into the right atrium: rare cause for continuous murmur. (4262543)
1972
48
Treatment of epididymitis. (21004806)
1945

Variations for African Tick-Bite Fever

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Expression for genes affiliated with African Tick-Bite Fever

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Search GEO for disease gene expression data for African Tick-Bite Fever.

Pathways for genes affiliated with African Tick-Bite Fever

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Pathways related to African Tick-Bite Fever according to GeneCards Suite gene sharing:

(show all 36)
idSuper pathwaysScoreTop Affiliating Genes
19.8IFNG, IL10, IL13
29.8IFNG, IL10, IL13
39.8IFNG, IL10, SELE
4
Show member pathways
9.7CD40LG, CXCL8, IFNG
59.7CXCL8, IFNG, SELE
69.7IFNG, IL10, THBD
79.7CD40LG, CXCL8, TLR4
89.6CXCL8, IL10, TLR4
99.6CXCL8, SELE, THBD
10
Show member pathways
9.6IFNG, TLR2, TLR4
119.6IFNG, TLR2, TLR4
129.5CXCL8, IFNG, IL13, SELE
139.5CD40LG, CX3CL1, TLR4
149.4CXCL8, TLR2, TLR4
159.3CD40LG, IL10, TLR2, TLR4
16
Show member pathways
9.3IFNG, IL10, TLR2, TLR4
179.3IFNG, IL10, TLR2, TLR4
189.3IFNG, IL10, IL13, IL15
19
Show member pathways
9.3IFNG, IL10, IL13, IL15
20
Show member pathways
9.2CXCL8, IFNG, TLR2, TLR4
21
Show member pathways
9.1CD40LG, IFNG, IL10, TLR2, TLR4
22
Show member pathways
9.0CD40LG, IFNG, IL10, TLR2, TLR4
239.0CXCL8, IFNG, IL10, TLR2, TLR4
24
Show member pathways
9.0CXCL8, IFNG, IL10, IL13, IL15
25
Show member pathways
8.9CCL3, IFNG, IL10, IL15
268.8CCL5, CX3CL1, IL15, SELE
278.7CCL3, IFNG, IL10, IL13, IL15
28
Show member pathways
8.6CCL3, CCL5, CX3CL1, CXCL8
298.6CD40LG, CXCL8, IFNG, IL10, SELE, TLR2
30
Show member pathways
8.4CD40LG, IFNG, IL10, IL13, IL15, TLR2
31
Show member pathways
8.1CCL5, CXCL8, IFNG, IL13, IL15, TLR2
32
Show member pathways
8.0CCL3, CCL5, CXCL8, IFNG, IL10, TLR2
337.7CCL3, CCL5, CXCL8, IFNG, IL15, TLR2
34
Show member pathways
7.5CCL3, CCL5, CD40LG, CX3CL1, CXCL8, IL10
35
Show member pathways
6.9CCL3, CCL5, CD40LG, CX3CL1, CXCL8, IFNG
36
Show member pathways
6.7CCL3, CCL5, CD40LG, CX3CL1, CXCL8, IL10

GO Terms for genes affiliated with African Tick-Bite Fever

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Cellular components related to African Tick-Bite Fever according to GeneCards Suite gene sharing:

idNameGO IDScoreTop Affiliating Genes
1external side of plasma membraneGO:00098979.8CD40LG, IL13, TLR4

Biological processes related to African Tick-Bite Fever according to GeneCards Suite gene sharing:

(show all 45)
idNameGO IDScoreTop Affiliating Genes
1defense response to protozoanGO:004283210.7IFNG, IL10
2positive regulation of membrane protein ectodomain proteolysisGO:005104410.7ADRA2A, IFNG
3negative regulation of interleukin-17 productionGO:003270010.7IFNG, TLR4
4positive regulation of interleukin-12 biosynthetic processGO:004508410.7IFNG, TLR4
5negative regulation of growth of symbiont in hostGO:004413010.7IFNG, IL10
6leukocyte cell-cell adhesionGO:000715910.6CCL5, CD40LG
7positive regulation of interleukin-10 productionGO:003273310.5CD40LG, TLR4
8cellular response to cytokine stimulusGO:007134510.5CCL5, IL13
9positive regulation of chemokine productionGO:003272210.5TLR2, TLR4
10neutrophil activationGO:004211910.5CCL5, CXCL8
11positive regulation of nitric-oxide synthase biosynthetic processGO:005177010.4TLR2, TLR4
12I-kappaB phosphorylationGO:000725210.4TLR2, TLR4
13positive regulation of osteoclast differentiationGO:004567210.4CCL5, IFNG
14negative regulation of G-protein coupled receptor protein signaling pathwayGO:004574410.4CCL5, CXCL8
15microglial cell activationGO:000177410.2CX3CL1, IL13
16positive regulation of MHC class II biosynthetic processGO:004534810.2IFNG, IL10, TLR4
17positive regulation of macrophage chemotaxisGO:001075910.2CCL5, CX3CL1
18positive regulation of interleukin-12 productionGO:003273510.2IFNG, TLR2, TLR4
19positive regulation of tumor necrosis factor productionGO:003276010.2IFNG, TLR2, TLR4
20cellular response to lipoteichoic acidGO:007122310.2TLR2, TLR4
21positive regulation of natural killer cell chemotaxisGO:200050310.1CCL3, CCL5
22negative regulation of osteoclast differentiationGO:004567110.1CCL3, TLR4
23eosinophil chemotaxisGO:004824510.1CCL3, CCL5
24response to cholesterolGO:007072310.1CCL3, CCL5
25protein kinase B signalingGO:004349110.0CCL3, CCL5
26movement of cell or subcellular componentGO:000692810.0ADRA2A, CXCL8, IFNG, IL13
27macrophage chemotaxisGO:004824610.0CCL3, CX3CL1
28positive regulation of cell adhesionGO:00457859.9CCL5, CX3CL1, IFNG
29neutrophil chemotaxisGO:00305939.9CX3CL1, CXCL8, IFNG
30positive regulation of smooth muscle cell proliferationGO:00486619.8CCL5, CX3CL1, IL13
31defense response to bacteriumGO:00427429.8IFNG, IL10, TLR4
32cellular response to lipopolysaccharideGO:00712229.5CCL5, CXCL8, IFNG, TLR4
33response to lipopolysaccharideGO:00324969.4CCL5, IL10, IL13, SELE
34monocyte chemotaxisGO:00025489.3CCL3, CCL5, CX3CL1
35cellular response to interferon-gammaGO:00713469.3CCL3, CCL5, CX3CL1
36agingGO:00075689.2CCL5, CX3CL1, IL10, IL15
37lipopolysaccharide-mediated signaling pathwayGO:00316639.2CCL3, CCL5, TLR2, TLR4
38inflammatory responseGO:00069549.1CCL5, CX3CL1, IL10, IL15
39cellular response to tumor necrosis factorGO:00713569.1CCL3, CX3CL1, CXCL8
40cell-cell signalingGO:00072678.8CCL3, CCL5, IL10, IL13, IL15
41positive regulation of gene expressionGO:00106288.7CCL3, CCL5, IFNG, TLR4
42signal transductionGO:00071658.4ADRA2A, CXCL8, IL13, IL15, TLR2, TLR4
43G-protein coupled receptor signaling pathwayGO:00071868.3ADRA2A, CCL3, CCL5, CX3CL1, CXCL8
44positive regulation of inflammatory responseGO:00507298.1CCL3, CCL5, CX3CL1, IL15, TLR2, TLR4
45immune responseGO:00069557.0CCL3, CCL5, CX3CL1, CXCL8, IFNG, IL10

Sources for African Tick-Bite Fever

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2CDC
14ExPASy
15FDA
16FMA
24GTR
25HGMD
26HMDB
27ICD10
28ICD10 via Orphanet
29ICD9CM
30IUPHAR
31KEGG
34MedGen
36MeSH
37MESH via Orphanet
38MGI
41NCI
42NCIt
43NDF-RT
46NINDS
47Novoseek
49OMIM
50OMIM via Orphanet
54PubMed
55QIAGEN
60SNOMED-CT via Orphanet
64Tumor Gene Family of Databases
65UMLS
66UMLS via Orphanet