MCID: AFR002
MIFTS: 33

African Tick-Bite Fever malady

Category: Infectious diseases

Aliases & Classifications for African Tick-Bite Fever

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Aliases & Descriptions for African Tick-Bite Fever:

Name: African Tick-Bite Fever 11 13
Rickettsia Africae Spotted Fever 11
 
South African Tick-Bite Fever 11
African Tick Bite Fever 67

Classifications:



External Ids:

Disease Ontology11 DOID:0050035

Summaries for African Tick-Bite Fever

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Disease Ontology:11 A spotted fever that has material basis in Rickettsia africae, which is transmitted by ticks (Amblyomma hebraeum and Amblyomma variegatum). The infection has symptom fever, has symptom eschar and has symptom maculopapular rash.

MalaCards based summary: African Tick-Bite Fever, also known as rickettsia africae spotted fever, is related to boutonneuse fever and endometrial stromal nodule, and has symptoms including fever, eschar and maculopapular rash. An important gene associated with African Tick-Bite Fever is CD40LG (CD40 Ligand), and among its related pathways are Calcineurin-regulated NFAT-dependent transcription in lymphocytes and Inflammatory Response Pathway. Affiliated tissues include endothelial, and related mouse phenotypes are integument and hematopoietic system.

Wikipedia:70 African tick bite fever (ATBF) is a disease caused by the bacterium Rickettsia africae in sub-Saharan... more...

Related Diseases for African Tick-Bite Fever

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Diseases related to African Tick-Bite Fever via text searches within MalaCards or GeneCards Suite gene sharing:

(show top 50)    (show all 133)
idRelated DiseaseScoreTop Affiliating Genes
1boutonneuse fever12.0
2endometrial stromal nodule10.3CD40LG, IFNG
3abdominal tuberculosis10.3CD40LG, IL13
4spastic monoplegia10.3CD40LG, IL13
5acrorenal syndrome10.3CD40LG, IFNG
6pneumonic tularemia10.3CD40LG, IFNG
7malignant histiocytosis10.3CD40LG, IFNG
8gait apraxia10.3CD40LG, IL13
9fibrous histiocytoma10.3CD40LG, IFNG
10oesophagostomiasis10.3CD40LG, IFNG
11compensatory emphysema10.3CD40LG, IFNG
12bartonellosis10.3CD40LG, IFNG
13binocular vision disease10.3CD40LG, IFNG
14lacrimal system cancer10.3CD40LG, IFNG
15bile duct signet ring cell carcinoma10.3CD40LG, IFNG
16intrinsic cardiomyopathy10.3CD40LG, IFNG
17chronic conjunctivitis10.3CD40LG, IFNG
18metagonimiasis10.3CD40LG, IL13
19reproductive system disease10.3CD40LG, IFNG
20progressive relapsing multiple sclerosis10.3CD40LG, IFNG
21subendocardial infarction acute myocardial infarction10.3CD40LG, IFNG
22goat milk allergy10.3IFNG, IL13
23cholesteatoma of middle ear10.3IFNG, IL13
24esophagus melanoma10.3CD40LG, IFNG
25acute gonococcal salpingitis10.3IFNG, IL13
26bacteriuria10.3CD40LG, IFNG
27orbit alveolar rhabdomyosarcoma10.2IFNG, IL13
28biliary tract disease10.2CD40LG, IL13
29loeffler syndrome10.2CD40LG, IL13
30malignant neoplasm of acoustic nerve10.2IFNG, IL13
31parasitic helminthiasis infectious disease10.2CD40LG, SELE
32buphthalmos10.2IFNG, IL13
33bartter disease10.2CD40LG, IFNG
34chromoblastomycosis10.2CD40LG, SELE
35tetanus neonatorum10.2IFNG, IL13
36opportunistic bacterial infectious disease10.2CD40LG, IFNG
37stickler sydrome, type i, nonsyndromic ocular10.2CD40LG, SELE
38idiopathic interstitial pneumonia10.2CD40LG, IFNG
39alternating exotropia10.2CD40LG, IFNG
40labyrinthine bilateral reactive loss10.2CD40LG, SELE
41hemorrhagic fever with renal syndrome10.2CD40LG, IFNG
42uterine inversion10.2CD40LG, IFNG
43blood group incompatibility10.2CD40LG, IFNG
44dengue disease10.2IFNG, IL13
45churg-strauss syndrome10.2IFNG, IL13
46xanthomatosis10.2CD40LG, IFNG
47exophthalmos10.2IFNG, IL13
48mixed lacrimal gland cancer10.2CD40LG, IFNG
49gonococcal synovitis10.2IFNG, SELE
50conventional malignant hemangiopericytoma10.2IFNG, IL13

Graphical network of the top 20 diseases related to African Tick-Bite Fever:



Diseases related to african tick-bite fever

Symptoms for African Tick-Bite Fever

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Symptoms:

 11
  • fever
  • eschar
  • maculopapular rash

Drugs & Therapeutics for African Tick-Bite Fever

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Interventional clinical trials:

Search ClinicalTrials, NIH Clinical Center for African Tick-Bite Fever

Genetic Tests for African Tick-Bite Fever

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Anatomical Context for African Tick-Bite Fever

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MalaCards organs/tissues related to African Tick-Bite Fever:

35
Endothelial

Animal Models for African Tick-Bite Fever or affiliated genes

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MGI Mouse Phenotypes related to African Tick-Bite Fever:

40
idDescriptionMGI Source AccessionScoreTop Affiliating Genes
1MP:00107718.4CD40LG, IFNG, IL13, SELE
2MP:00053978.3CCL5, CD40LG, IFNG, IL13, SELE
3MP:00053878.3CCL5, CD40LG, IFNG, IL13, SELE

Publications for African Tick-Bite Fever

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Articles related to African Tick-Bite Fever:

(show top 50)    (show all 52)
idTitleAuthorsYear
1
A case of African tick-bite fever in a returning traveler. (27516971)
2016
2
African tick bite fever. (27929573)
2016
3
Molecular diagnosis of African tick bite fever using eschar swabs in a traveller returning from Tanzania. (27488618)
2016
4
African Tick-Bite Fever in Traveler Returning to Slovenia from Uganda. (27648844)
2016
5
First case of imported African tick-bite fever in Poland - Case report. (26403104)
2015
6
Images in clinical medicine: African tick-bite fever after a game-hunting expedition. (25738687)
2015
7
African Tick-Bite Fever in a Returning Traveler. (25795527)
2015
8
A family with African tick bite fever. (25886872)
2015
9
Case report of African tick-bite fever from Poland. (24494003)
2013
10
Cutaneous leishmaniasis and rickettsial African tick-bite fever: a combination of exotic traveler's diseases in the same patient. (22788813)
2012
11
The use of eschar swabs for the diagnosis of African tick-bite fever. (23141102)
2012
12
Risk factors for African tick-bite fever in rural central Africa. (21460018)
2011
13
Neurological picture. Internuclear ophthalmoplegia following African tick bite fever. (21421770)
2011
14
African tick-bite fever: a new entity in the differential diagnosis of multiple eschars in travelers. Description of five cases imported from South Africa to Switzerland. (20233665)
2010
15
Relative chemokine and adhesion molecule expression in Mediterranean spotted fever and African tick bite fever. (19091423)
2009
16
Unusual location of an inoculation lesion in a traveler with African tick-bite fever returning from South Africa. (19930389)
2009
17
African tick bite Fever in a Taiwanese traveler returning from South Africa: molecular and serologic studies. (19861602)
2009
18
Tache noire in African tick bite fever. (19861601)
2009
19
Diagnosis of Queensland tick typhus and African tick bite fever by PCR of lesion swabs. (19523304)
2009
20
African tick bite fever--papulovesicular exanthem with fever after staying in South Africa. (18021248)
2008
21
African tick bite fever in elderly patients: 8 cases in French tourists returning from South Africa. (18558881)
2008
22
African tick bite fever. (18218581)
2008
23
Two cases of cellulitis in the course of African tick bite fever: a fortuitous association? (18503259)
2008
24
African tick bite fever in a returned traveler. (17939635)
2007
25
African tick bite fever. (17067925)
2006
26
African tick bite fever: a not-so-uncommon illness in international travelers. (17043186)
2006
27
Histologic features and immunodetection of African tick-bite fever eschar. (17073080)
2006
28
Sub-acute neuropathy in patients with African tick bite fever. (16449002)
2006
29
Increased levels of soluble CD40L in African tick bite fever: possible involvement of TLRs in the pathogenic interaction between Rickettsia africae, endothelial cells, and platelets. (16888032)
2006
30
Cardiac involvement in a patient with clinical and serological evidence of African tick-bite fever. (16242016)
2005
31
African tick-bite fever in French travelers. (16422013)
2005
32
Comparison of immunofluorescence, Western blotting, and cross-adsorption assays for diagnosis of African tick bite fever. (15242958)
2004
33
African tick-bite fever. (15301327)
2004
34
African tick bite fever: not a spotless rickettsiosis! (12582376)
2003
35
Systemic inflammatory responses in African tick-bite fever. (12696016)
2003
36
African tick bite fever. (12954562)
2003
37
African tick bite fever in travelers to rural sub-Equatorial Africa. (12766836)
2003
38
Sequential changes in hematologic and biochemical parameters in African tick bite fever. (12925109)
2003
39
Outbreak of African tick-bite fever in six Italian tourists returning from South Africa. (11939395)
2002
40
African tick-bite fever in South Africa. (12379945)
2002
41
Imported African tick bite fever: a case report. (10344666)
1999
42
African tick-bite fever among international travelers--Oregon, 1998. (9832471)
1998
43
African Tick-Bite Fever: A Case Report. (9815517)
1997
44
African tick-bite fever. An imported spotless rickettsiosis. (8996049)
1997
45
Rickettsia africae sp. nov., the etiological agent of African tick bite fever. (8934912)
1996
46
South African tick-bite fever complicated by severe encephalopathy. (1598654)
1992
47
African tick-bite fever: a new spotted fever group rickettsiosis under an old name. (1357393)
1992
48
Correlation of the distribution of Rickettsia conorii, microscopic lesions, and clinical features in South African tick bite fever. (3885774)
1985
49
South African tick-bite fever (1931-1981). (7036374)
1981
50
A method for increasing the infectivity of yolk-sac cultures of the rickettsiae of epidemic and murine typhus, and South African tick-bite fever. (20282007)
1946

Variations for African Tick-Bite Fever

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Expression for genes affiliated with African Tick-Bite Fever

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Search GEO for disease gene expression data for African Tick-Bite Fever.

Pathways for genes affiliated with African Tick-Bite Fever

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Pathways related to African Tick-Bite Fever according to GeneCards Suite gene sharing:

(show all 19)
idSuper pathwaysScoreTop Affiliating Genes
1
Show member pathways
9.5CD40LG, IFNG
29.5CD40LG, IFNG
39.4IFNG, IL13
49.4IFNG, IL13
59.4IFNG, IL13
69.4IFNG, IL13
79.4IFNG, IL13
89.3IFNG, SELE
99.3IFNG, SELE
109.1CCL5, IFNG
119.0CCL5, SELE
129.0CCL5, SELE
13
Show member pathways
9.0CD40LG, IFNG, IL13
148.9CD40LG, IFNG, SELE
158.8IFNG, IL13, SELE
168.7CCL5, CD40LG, IFNG
178.7CCL5, CD40LG, IL13
18
Show member pathways
8.6CCL5, IFNG, IL13
19
Show member pathways
8.6CCL5, IFNG, IL13

GO Terms for genes affiliated with African Tick-Bite Fever

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Cellular components related to African Tick-Bite Fever according to GeneCards Suite gene sharing:

idNameGO IDScoreTop Affiliating Genes
1external side of plasma membraneGO:00098979.0CD40LG, IFNG, IL13
2extracellular spaceGO:00056157.5CCL5, CD40LG, IFNG, IL13, SELE

Biological processes related to African Tick-Bite Fever according to GeneCards Suite gene sharing:

(show all 13)
idNameGO IDScoreTop Affiliating Genes
1positive regulation of interleukin-12 productionGO:003273510.0CD40LG, IFNG
2positive regulation of osteoclast differentiationGO:00456729.6CCL5, IFNG
3regulation of insulin secretionGO:00507969.6CCL5, IFNG
4positive regulation of smooth muscle cell proliferationGO:00486619.5CCL5, IL13
5positive regulation of cell adhesionGO:00457859.5CCL5, IFNG
6negative regulation of neuron deathGO:19012159.4CCL5, IL13
7neutrophil chemotaxisGO:00305939.4CCL5, IFNG
8response to tumor necrosis factorGO:00346129.3CCL5, SELE
9positive regulation of neuron differentiationGO:00456669.1CCL5, IFNG
10movement of cell or subcellular componentGO:00069289.1IFNG, IL13
11leukocyte cell-cell adhesionGO:00071599.1CCL5, CD40LG, SELE
12positive regulation of T cell proliferationGO:00421028.8CCL5, CD40LG, IFNG
13inflammatory responseGO:00069548.1CCL5, CD40LG, IL13, SELE

Molecular functions related to African Tick-Bite Fever according to GeneCards Suite gene sharing:

idNameGO IDScoreTop Affiliating Genes
1cytokine activityGO:00051259.0CD40LG, IFNG, IL13

Sources for African Tick-Bite Fever

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2CDC
6CNVD
10DGIdb
15ExPASy
16FDA
17FMA
26GTR
27HGMD
28HMDB
29ICD10
30ICD10 via Orphanet
31ICD9CM
32IUPHAR
33KEGG
36MedGen
38MeSH
39MESH via Orphanet
40MGI
43NCI
44NCIt
45NDF-RT
48NINDS
49Novoseek
51OMIM
52OMIM via Orphanet
56PubMed
57QIAGEN
62SNOMED-CT via Orphanet
66Tumor Gene Family of Databases
67UMLS
68UMLS via Orphanet