MCID: AFR002
MIFTS: 33

African Tick-Bite Fever malady

Category: Infectious diseases

Aliases & Classifications for African Tick-Bite Fever

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Aliases & Descriptions for African Tick-Bite Fever:

Name: African Tick-Bite Fever 11 13
Rickettsia Africae Spotted Fever 11
 
South African Tick-Bite Fever 11
African Tick Bite Fever 68

Classifications:



External Ids:

Disease Ontology11 DOID:0050035

Summaries for African Tick-Bite Fever

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Disease Ontology:11 A spotted fever that has material basis in Rickettsia africae, which is transmitted by ticks (Amblyomma hebraeum and Amblyomma variegatum). The infection has symptom fever, has symptom eschar and has symptom maculopapular rash.

MalaCards based summary: African Tick-Bite Fever, also known as rickettsia africae spotted fever, is related to boutonneuse fever and centronuclear myopathy 5, and has symptoms including fever, eschar and maculopapular rash. An important gene associated with African Tick-Bite Fever is CD40LG (CD40 Ligand), and among its related pathways are Calcineurin-regulated NFAT-dependent transcription in lymphocytes and Inflammatory Response Pathway. Affiliated tissues include endothelial, and related mouse phenotypes are integument and hematopoietic system.

Wikipedia:71 African tick bite fever (ATBF) is a disease caused by the bacterium Rickettsia africae in sub-Saharan... more...

Related Diseases for African Tick-Bite Fever

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Diseases related to African Tick-Bite Fever via text searches within MalaCards or GeneCards Suite gene sharing:

(show top 50)    (show all 126)
idRelated DiseaseScoreTop Affiliating Genes
1boutonneuse fever12.0
2centronuclear myopathy 510.2CD40LG, IFNG
3conduct disorder10.2CD40LG, IFNG
4pancreatic signet ring cell adenocarcinoma10.2CD40LG, IFNG
5tularemia10.2CD40LG, IFNG
6intravascular angioleiomyoma10.2CD40LG, IL13
7oral cavity cancer10.2CD40LG, IFNG
8central nervous system origin vertigo10.2CD40LG, IFNG
9hereditary alpha tryptasemia syndrome10.2CD40LG, IFNG
10rickettsialpox10.2CD40LG, IFNG
11benign deep fibrous histiocytoma10.2CD40LG, IFNG
12hyperlucent lung10.2CD40LG, IFNG
13plummer's disease10.2CD40LG, IFNG
14oropharynx cancer10.2CD40LG, IFNG
15crustacean allergy10.2IFNG, IL13
16spastic diplegia10.2IFNG, IL13
17acute gonococcal prostatitis10.2IFNG, IL13
18disease of mental health10.2CD40LG, IFNG
19myofibroma10.2IFNG, IL13
20malignant oculomotor nerve tumor10.1IFNG, IL13
21proximal symphalangism10.1CD40LG, IFNG
22autoimmune disease of skin and connective tissue10.1CD40LG, IFNG
23myiasis10.1CD40LG, IFNG
24heart conduction disease10.1CD40LG, IFNG
25motor peripheral neuropathy10.1CD40LG, IFNG
26tonsil cancer10.1CD40LG, SELE
27depressed scar10.1CD40LG, IFNG
28actinic keratosis10.1CD40LG, IL13
29czech dysplasia10.1CD40LG, SELE
30dermatomycosis10.1CD40LG, SELE
31hydrophthalmos10.1IFNG, IL13
32loiasis10.1IFNG, IL13
33powassan encephalitis10.1CD40LG, SELE
34xanthogranulomatous cholecystitis10.1CD40LG, IL13
35dracunculiasis10.1CD40LG, SELE
36anterior foramen magnum meningioma10.1CD40LG, IFNG
37radial hypoplasia, triphalangeal thumbs and hypospadias10.1CD40LG, SELE
38urethral intrinsic sphincter deficiency10.1IFNG, SELE
39acute dacryoadenitis10.1CD40LG, IL13
40rosacea10.1IFNG, SELE
41hallucinogen dependence10.1CD40LG, IFNG
42chronic thromboembolic pulmonary hypertension10.1IFNG, SELE
43tracheitis10.1IFNG, IL13
44spotted fever10.1
45paratyphoid fever10.1IFNG, IL13
46childhood choriocarcinoma of the testis10.1CD40LG, IL13
47thyroid hyalinizing trabecular adenoma10.1IFNG, IL13
48keratomalacia10.1CD40LG, IFNG
49dengue hemorrhagic fever10.1IFNG, IL13
50nonspecific interstitial pneumonia10.1CD40LG, IFNG

Graphical network of the top 20 diseases related to African Tick-Bite Fever:



Diseases related to african tick-bite fever

Symptoms & Phenotypes for African Tick-Bite Fever

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Symptoms:

 11
  • fever
  • eschar
  • maculopapular rash

MGI Mouse Phenotypes related to African Tick-Bite Fever according to GeneCards Suite gene sharing:

41
idDescriptionMGI Source AccessionScoreTop Affiliating Genes
1MP:00107718.4CD40LG, IFNG, IL13, SELE
2MP:00053978.3CCL5, CD40LG, IFNG, IL13, SELE
3MP:00053878.3CCL5, CD40LG, IFNG, IL13, SELE

Drugs & Therapeutics for African Tick-Bite Fever

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Interventional clinical trials:

Search ClinicalTrials, NIH Clinical Center for African Tick-Bite Fever

Genetic Tests for African Tick-Bite Fever

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Anatomical Context for African Tick-Bite Fever

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MalaCards organs/tissues related to African Tick-Bite Fever:

36
Endothelial

Publications for African Tick-Bite Fever

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Articles related to African Tick-Bite Fever:

(show top 50)    (show all 52)
idTitleAuthorsYear
1
A case of African tick-bite fever in a returning traveler. (27516971)
2016
2
African tick bite fever. (27929573)
2016
3
African Tick-Bite Fever in Traveler Returning to Slovenia from Uganda. (27648844)
2016
4
Molecular diagnosis of African tick bite fever using eschar swabs in a traveller returning from Tanzania. (27488618)
2016
5
A family with African tick bite fever. (25886872)
2015
6
Images in clinical medicine: African tick-bite fever after a game-hunting expedition. (25738687)
2015
7
First case of imported African tick-bite fever in Poland - Case report. (26403104)
2015
8
African Tick-Bite Fever in a Returning Traveler. (25795527)
2015
9
Case report of African tick-bite fever from Poland. (24494003)
2013
10
Cutaneous leishmaniasis and rickettsial African tick-bite fever: a combination of exotic traveler's diseases in the same patient. (22788813)
2012
11
The use of eschar swabs for the diagnosis of African tick-bite fever. (23141102)
2012
12
Risk factors for African tick-bite fever in rural central Africa. (21460018)
2011
13
Neurological picture. Internuclear ophthalmoplegia following African tick bite fever. (21421770)
2011
14
African tick-bite fever: a new entity in the differential diagnosis of multiple eschars in travelers. Description of five cases imported from South Africa to Switzerland. (20233665)
2010
15
Tache noire in African tick bite fever. (19861601)
2009
16
Relative chemokine and adhesion molecule expression in Mediterranean spotted fever and African tick bite fever. (19091423)
2009
17
Diagnosis of Queensland tick typhus and African tick bite fever by PCR of lesion swabs. (19523304)
2009
18
Unusual location of an inoculation lesion in a traveler with African tick-bite fever returning from South Africa. (19930389)
2009
19
African tick bite Fever in a Taiwanese traveler returning from South Africa: molecular and serologic studies. (19861602)
2009
20
African tick bite fever--papulovesicular exanthem with fever after staying in South Africa. (18021248)
2008
21
African tick bite fever in elderly patients: 8 cases in French tourists returning from South Africa. (18558881)
2008
22
African tick bite fever. (18218581)
2008
23
Two cases of cellulitis in the course of African tick bite fever: a fortuitous association? (18503259)
2008
24
African tick bite fever in a returned traveler. (17939635)
2007
25
Increased levels of soluble CD40L in African tick bite fever: possible involvement of TLRs in the pathogenic interaction between Rickettsia africae, endothelial cells, and platelets. (16888032)
2006
26
Sub-acute neuropathy in patients with African tick bite fever. (16449002)
2006
27
African tick bite fever: a not-so-uncommon illness in international travelers. (17043186)
2006
28
Histologic features and immunodetection of African tick-bite fever eschar. (17073080)
2006
29
African tick bite fever. (17067925)
2006
30
Cardiac involvement in a patient with clinical and serological evidence of African tick-bite fever. (16242016)
2005
31
African tick-bite fever in French travelers. (16422013)
2005
32
Comparison of immunofluorescence, Western blotting, and cross-adsorption assays for diagnosis of African tick bite fever. (15242958)
2004
33
African tick-bite fever. (15301327)
2004
34
African tick-bite fever: four cases among Swiss travelers returning from South Africa. (15541225)
2004
35
Sequential changes in hematologic and biochemical parameters in African tick bite fever. (12925109)
2003
36
African tick bite fever in travelers to rural sub-Equatorial Africa. (12766836)
2003
37
African tick bite fever: not a spotless rickettsiosis! (12582376)
2003
38
African tick bite fever. (12954562)
2003
39
Systemic inflammatory responses in African tick-bite fever. (12696016)
2003
40
Outbreak of African tick-bite fever in six Italian tourists returning from South Africa. (11939395)
2002
41
African tick-bite fever in South Africa. (12379945)
2002
42
African tick-bite fever imported into Norway: presentation of 8 cases. (10447320)
1999
43
Imported African tick bite fever: a case report. (10344666)
1999
44
African tick-bite fever among international travelers--Oregon, 1998. (9832471)
1998
45
African Tick-Bite Fever: A Case Report. (9815517)
1997
46
African tick-bite fever. An imported spotless rickettsiosis. (8996049)
1997
47
Rickettsia africae sp. nov., the etiological agent of African tick bite fever. (8934912)
1996
48
African tick-bite fever: a new spotted fever group rickettsiosis under an old name. (1357393)
1992
49
South African tick-bite fever complicated by severe encephalopathy. (1598654)
1992
50
Correlation of the distribution of Rickettsia conorii, microscopic lesions, and clinical features in South African tick bite fever. (3885774)
1985

Variations for African Tick-Bite Fever

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Expression for genes affiliated with African Tick-Bite Fever

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Search GEO for disease gene expression data for African Tick-Bite Fever.

Pathways for genes affiliated with African Tick-Bite Fever

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Pathways related to African Tick-Bite Fever according to GeneCards Suite gene sharing:

(show all 22)
idSuper pathwaysScoreTop Affiliating Genes
1
Show member pathways
9.5CD40LG, IFNG
29.5CD40LG, IFNG
39.4IFNG, IL13
49.4IFNG, IL13
59.4IFNG, IL13
69.4IFNG, IL13
79.4IFNG, IL13
89.4IFNG, IL13
99.3IFNG, SELE
109.3IFNG, SELE
119.1CCL5, IFNG
129.1CCL5, IL13
139.1CCL5, IL13
149.0CCL5, SELE
15
Show member pathways
9.0CD40LG, IFNG, IL13
16
Show member pathways
8.9CD40LG, IFNG, SELE
178.9CD40LG, IFNG, SELE
188.8IFNG, IL13, SELE
198.7CCL5, CD40LG, IFNG
208.7CCL5, CD40LG, IL13
21
Show member pathways
8.6CCL5, IFNG, IL13
22
Show member pathways
8.2CCL5, CD40LG, IFNG, IL13

GO Terms for genes affiliated with African Tick-Bite Fever

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Cellular components related to African Tick-Bite Fever according to GeneCards Suite gene sharing:

idNameGO IDScoreTop Affiliating Genes
1external side of plasma membraneGO:00098979.7CD40LG, IFNG, IL13
2extracellular spaceGO:00056157.5CCL5, CD40LG, IFNG, IL13, SELE

Biological processes related to African Tick-Bite Fever according to GeneCards Suite gene sharing:

(show all 12)
idNameGO IDScoreTop Affiliating Genes
1positive regulation of interleukin-12 productionGO:003273510.1CD40LG, IFNG
2movement of cell or subcellular componentGO:000692810.1IFNG, IL13
3neutrophil chemotaxisGO:00305939.8CCL5, IFNG
4positive regulation of cell adhesionGO:00457859.7CCL5, IFNG
5positive regulation of smooth muscle cell proliferationGO:00486619.7CCL5, IL13
6positive regulation of tyrosine phosphorylation of STAT proteinGO:00425319.7CCL5, IFNG
7regulation of insulin secretionGO:00507969.5CCL5, IFNG
8positive regulation of T cell proliferationGO:00421029.2CCL5, CD40LG, IFNG
9leukocyte cell-cell adhesionGO:00071599.2CCL5, CD40LG, SELE
10response to tumor necrosis factorGO:00346129.0CCL5, SELE
11immune responseGO:00069558.8CCL5, CD40LG, IFNG, IL13
12inflammatory responseGO:00069548.7CCL5, CD40LG, IL13, SELE

Molecular functions related to African Tick-Bite Fever according to GeneCards Suite gene sharing:

idNameGO IDScoreTop Affiliating Genes
1cytokine activityGO:00051258.2CCL5, CD40LG, IFNG, IL13

Sources for African Tick-Bite Fever

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2CDC
6CNVD
10DGIdb
15ExPASy
16FDA
17FMA
27GTR
28HGMD
29HMDB
30ICD10
31ICD10 via Orphanet
32ICD9CM
33IUPHAR
34KEGG
37MedGen
39MeSH
40MESH via Orphanet
41MGI
44NCI
45NCIt
46NDF-RT
49NINDS
50Novoseek
52OMIM
53OMIM via Orphanet
57PubMed
58QIAGEN
63SNOMED-CT via Orphanet
67Tumor Gene Family of Databases
68UMLS
69UMLS via Orphanet