MCID: AFR002
MIFTS: 36

African Tick-Bite Fever

Categories: Infectious diseases

Aliases & Classifications for African Tick-Bite Fever

MalaCards integrated aliases for African Tick-Bite Fever:

Name: African Tick-Bite Fever 12 14
Rickettsia Africae Spotted Fever 12
South African Tick-Bite Fever 12
African Tick Bite Fever 69

Classifications:



External Ids:

Disease Ontology 12 DOID:0050035
UMLS 69 C1320317

Summaries for African Tick-Bite Fever

Disease Ontology : 12 A spotted fever that has material basis in Rickettsia africae, which is transmitted_by ticks (Amblyomma hebraeum and Amblyomma variegatum). The infection has symptom fever, has symptom eschar and has symptom maculopapular rash.

MalaCards based summary : African Tick-Bite Fever, also known as rickettsia africae spotted fever, is related to spotted fever and cutaneous leishmaniasis, and has symptoms including fever, eschar and maculopapular rash. An important gene associated with African Tick-Bite Fever is CD40LG (CD40 Ligand), and among its related pathways/superpathways are Cytokine Signaling in Immune system and Allograft rejection. Affiliated tissues include endothelial, and related phenotypes are hematopoietic system and immune system

Related Diseases for African Tick-Bite Fever

Diseases related to African Tick-Bite Fever via text searches within MalaCards or GeneCards Suite gene sharing:

(show top 50) (show all 139)
# Related Disease Score Top Affiliating Genes
1 spotted fever 30.2 CCL5 IFNG
2 cutaneous leishmaniasis 30.2 IFNG IL13
3 leishmaniasis 30.0 IFNG IL13
4 boutonneuse fever 12.1
5 cat-scratch disease 10.3 CD40LG IFNG
6 sporotrichosis 10.2 CD40LG IFNG
7 buruli ulcer 10.2 CD40LG IFNG
8 eosinophilic meningitis 10.2 CD40LG IL13
9 intestinal schistosomiasis 10.2 CD40LG IL13
10 central nervous system vasculitis 10.2 CD40LG IFNG
11 primary systemic mycosis 10.2 CD40LG IFNG
12 coccidiosis 10.2 CD40LG IFNG
13 hemorrhagic fever 10.2 CD40LG IFNG
14 lichen disease 10.2 CD40LG IFNG
15 conjunctival disease 10.2 CD40LG IL13
16 q fever 10.2 CD40LG IFNG
17 hepatitis e 10.2 CD40LG IFNG
18 hypersensitivity reaction type iv disease 10.2 CD40LG IFNG
19 autoimmune disease of gastrointestinal tract 10.2 CD40LG IFNG
20 opportunistic mycosis 10.2 CD40LG IFNG
21 penicillin allergy 10.2 IFNG IL13
22 strongyloidiasis 10.2 IFNG IL13
23 vernal conjunctivitis 10.2 CD40LG IFNG
24 mixed connective tissue disease 10.2 CD40LG IFNG
25 echinococcosis 10.2 CD40LG IFNG
26 urinary schistosomiasis 10.2 IFNG IL13
27 parasitic helminthiasis infectious disease 10.2 CD40LG IL13
28 brucellosis 10.2 CD40LG IFNG
29 upper respiratory tract disease 10.2 CD40LG IL13
30 peanut allergy 10.2 IFNG IL13
31 leukocyte disease 10.2 CD40LG IL13
32 leprosy 3 10.2 CD40LG IFNG
33 nonspecific interstitial pneumonia 10.2 IFNG IL13
34 dengue hemorrhagic fever 10.2 CD40LG IFNG
35 mumps 10.2 CD40LG IFNG
36 heterophyiasis 10.2 CD40LG SELE
37 parasitic protozoa infectious disease 10.2 CD40LG IFNG
38 paranasal sinus disease 10.2 IFNG IL13
39 hypersensitivity reaction type iii disease 10.2 CD40LG SELE
40 legg-calve-perthes disease 10.2 CD40LG SELE
41 allergic conjunctivitis 10.2 IFNG IL13
42 pustulosis palmaris et plantaris 10.2 CD40LG SELE
43 primary bacterial infectious disease 10.1 CD40LG IFNG
44 critical illness polyneuropathy 10.1 CD40LG SELE
45 bone inflammation disease 10.1 CD40LG IFNG
46 cutaneous lupus erythematosus 10.1 CD40LG SELE
47 toxoplasmosis 10.1 CD40LG IFNG
48 actinic prurigo 10.1 IL13 SELE
49 conjunctivitis 10.1 IFNG IL13
50 chronic active epstein-barr virus infection 10.1 IFNG SELE

Graphical network of the top 20 diseases related to African Tick-Bite Fever:



Diseases related to African Tick-Bite Fever

Symptoms & Phenotypes for African Tick-Bite Fever

Symptoms:

12
  • fever
  • eschar
  • maculopapular rash

MGI Mouse Phenotypes related to African Tick-Bite Fever:

43
# Description MGI Source Accession Score Top Affiliating Genes
1 hematopoietic system MP:0005397 9.55 SELE CCL5 CD40LG IFNG IL13
2 immune system MP:0005387 9.35 CCL5 CD40LG IFNG IL13 SELE
3 integument MP:0010771 8.92 CD40LG IFNG IL13 SELE

Drugs & Therapeutics for African Tick-Bite Fever

Search Clinical Trials , NIH Clinical Center for African Tick-Bite Fever

Genetic Tests for African Tick-Bite Fever

Anatomical Context for African Tick-Bite Fever

MalaCards organs/tissues related to African Tick-Bite Fever:

38
Endothelial

Publications for African Tick-Bite Fever

Articles related to African Tick-Bite Fever:

(show top 50) (show all 55)
# Title Authors Year
1
African Tick Bite Fever Treated Successfully With Rifampin In A Patient With Doxycycline Intolerance. ( 28505276 )
2017
2
African tick bite fever in returning Swedish travellers. Report of two cases and aspects of diagnostics. ( 28815000 )
2017
3
African tick-bite fever - a tantalizing souvenir from South Africa. ( 28872753 )
2017
4
Molecular diagnosis of African tick bite fever using eschar swabs in a traveller returning from Tanzania. ( 27488618 )
2016
5
African Tick-Bite Fever in Traveler Returning to Slovenia from Uganda. ( 27648844 )
2016
6
A case of African tick-bite fever in a returning traveler. ( 27516971 )
2016
7
African tick bite fever. ( 27929573 )
2016
8
First case of imported African tick-bite fever in Poland - Case report. ( 26403104 )
2015
9
Images in clinical medicine: African tick-bite fever after a game-hunting expedition. ( 25738687 )
2015
10
A family with African tick bite fever. ( 25886872 )
2015
11
African Tick-Bite Fever in a Returning Traveler. ( 25795527 )
2015
12
Case report of African tick-bite fever from Poland. ( 24494003 )
2013
13
Cutaneous leishmaniasis and rickettsial African tick-bite fever: a combination of exotic traveler's diseases in the same patient. ( 22788813 )
2012
14
The use of eschar swabs for the diagnosis of African tick-bite fever. ( 23141102 )
2012
15
Neurological picture. Internuclear ophthalmoplegia following African tick bite fever. ( 21421770 )
2011
16
Risk factors for African tick-bite fever in rural central Africa. ( 21460018 )
2011
17
African tick-bite fever: a new entity in the differential diagnosis of multiple eschars in travelers. Description of five cases imported from South Africa to Switzerland. ( 20233665 )
2010
18
Diagnosis of Queensland tick typhus and African tick bite fever by PCR of lesion swabs. ( 19523304 )
2009
19
Unusual location of an inoculation lesion in a traveler with African tick-bite fever returning from South Africa. ( 19930389 )
2009
20
Tache noire in African tick bite fever. ( 19861601 )
2009
21
Relative chemokine and adhesion molecule expression in Mediterranean spotted fever and African tick bite fever. ( 19091423 )
2009
22
African tick bite Fever in a Taiwanese traveler returning from South Africa: molecular and serologic studies. ( 19861602 )
2009
23
African tick bite fever in elderly patients: 8 cases in French tourists returning from South Africa. ( 18558881 )
2008
24
African tick bite fever--papulovesicular exanthem with fever after staying in South Africa. ( 18021248 )
2008
25
African tick bite fever. ( 18218581 )
2008
26
Two cases of cellulitis in the course of African tick bite fever: a fortuitous association? ( 18503259 )
2008
27
African tick bite fever in a returned traveler. ( 17939635 )
2007
28
Sub-acute neuropathy in patients with African tick bite fever. ( 16449002 )
2006
29
African tick bite fever. ( 17067925 )
2006
30
African tick bite fever: a not-so-uncommon illness in international travelers. ( 17043186 )
2006
31
Increased levels of soluble CD40L in African tick bite fever: possible involvement of TLRs in the pathogenic interaction between Rickettsia africae, endothelial cells, and platelets. ( 16888032 )
2006
32
Histologic features and immunodetection of African tick-bite fever eschar. ( 17073080 )
2006
33
Cardiac involvement in a patient with clinical and serological evidence of African tick-bite fever. ( 16242016 )
2005
34
African tick-bite fever in French travelers. ( 16422013 )
2005
35
Comparison of immunofluorescence, Western blotting, and cross-adsorption assays for diagnosis of African tick bite fever. ( 15242958 )
2004
36
African tick-bite fever: four cases among Swiss travelers returning from South Africa. ( 15541225 )
2004
37
African tick-bite fever. ( 15301327 )
2004
38
African tick bite fever: not a spotless rickettsiosis! ( 12582376 )
2003
39
African tick bite fever in travelers to rural sub-Equatorial Africa. ( 12766836 )
2003
40
African tick bite fever. ( 12954562 )
2003
41
Sequential changes in hematologic and biochemical parameters in African tick bite fever. ( 12925109 )
2003
42
Systemic inflammatory responses in African tick-bite fever. ( 12696016 )
2003
43
African tick-bite fever in South Africa. ( 12379945 )
2002
44
Outbreak of African tick-bite fever in six Italian tourists returning from South Africa. ( 11939395 )
2002
45
Imported African tick bite fever: a case report. ( 10344666 )
1999
46
African tick-bite fever imported into Norway: presentation of 8 cases. ( 10447320 )
1999
47
African tick-bite fever among international travelers--Oregon, 1998. ( 9832471 )
1998
48
African Tick-Bite Fever: A Case Report. ( 9815517 )
1997
49
African tick-bite fever. An imported spotless rickettsiosis. ( 8996049 )
1997
50
Rickettsia africae sp. nov., the etiological agent of African tick bite fever. ( 8934912 )
1996

Variations for African Tick-Bite Fever

Expression for African Tick-Bite Fever

Search GEO for disease gene expression data for African Tick-Bite Fever.

Pathways for African Tick-Bite Fever

Pathways related to African Tick-Bite Fever according to GeneCards Suite gene sharing:

(show all 24)
# Super pathways Score Top Affiliating Genes
1
Show member pathways
12.95 CCL5 CD40LG IFNG IL13
2
Show member pathways
12.5 CD40LG IFNG IL13
3
Show member pathways
12.44 CCL5 IFNG IL13
4 12.18 CCL5 CD40LG IFNG
5 11.65 CCL5 SELE
6 11.57 CCL5 IFNG
7 11.5 IFNG IL13
8
Show member pathways
11.47 CD40LG IFNG
9 11.37 CCL5 IL13
10 11.3 IFNG SELE
11 11.25 IFNG IL13 SELE
12 11.24 CCL5 IL13
13 11.19 IFNG IL13
14 11.1 CCL5 SELE
15 11.02 IFNG SELE
16 10.98 CD40LG IFNG
17 10.94 IFNG IL13
18
Show member pathways
10.93 CD40LG IFNG SELE
19 10.88 IFNG IL13
20 10.82 IFNG IL13
21 10.74 IFNG IL13
22 10.68 CCL5 CD40LG IL13
23 10.66 CCL5 CD40LG IL13
24 10.49 CD40LG IFNG SELE

GO Terms for African Tick-Bite Fever

Cellular components related to African Tick-Bite Fever according to GeneCards Suite gene sharing:

# Name GO ID Score Top Affiliating Genes
1 extracellular space GO:0005615 9.02 CCL5 CD40LG IFNG IL13 SELE

Biological processes related to African Tick-Bite Fever according to GeneCards Suite gene sharing:

(show all 11)
# Name GO ID Score Top Affiliating Genes
1 immune response GO:0006955 9.62 CCL5 CD40LG IFNG IL13
2 regulation of receptor activity GO:0010469 9.56 CCL5 CD40LG IFNG IL13
3 movement of cell or subcellular component GO:0006928 9.49 IFNG IL13
4 regulation of insulin secretion GO:0050796 9.48 CCL5 IFNG
5 positive regulation of T cell proliferation GO:0042102 9.46 CCL5 CD40LG
6 inflammatory response GO:0006954 9.46 CCL5 CD40LG IL13 SELE
7 positive regulation of smooth muscle cell proliferation GO:0048661 9.43 CCL5 IL13
8 response to tumor necrosis factor GO:0034612 9.4 CCL5 SELE
9 positive regulation of interleukin-12 production GO:0032735 9.37 CD40LG IFNG
10 positive regulation of tyrosine phosphorylation of STAT protein GO:0042531 9.13 CCL5 IFNG IL13
11 leukocyte cell-cell adhesion GO:0007159 8.8 CCL5 CD40LG SELE

Molecular functions related to African Tick-Bite Fever according to GeneCards Suite gene sharing:

# Name GO ID Score Top Affiliating Genes
1 cytokine activity GO:0005125 8.92 CCL5 CD40LG IFNG IL13

Sources for African Tick-Bite Fever

3 CDC
7 CNVD
9 Cosmic
10 dbSNP
11 DGIdb
16 ExPASy
18 FMA
27 GO
28 GTR
29 HGMD
30 HMDB
31 HPO
32 ICD10
33 ICD10 via Orphanet
34 ICD9CM
35 IUPHAR
36 KEGG
37 LifeMap
39 MedGen
41 MeSH
42 MESH via Orphanet
43 MGI
45 NCI
46 NCIt
47 NDF-RT
50 NINDS
51 Novoseek
53 OMIM
54 OMIM via Orphanet
58 PubMed
60 QIAGEN
65 SNOMED-CT via HPO
66 SNOMED-CT via Orphanet
67 TGDB
68 Tocris
69 UMLS
70 UMLS via Orphanet
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