MCID: AFR002
MIFTS: 43

African Tick-Bite Fever malady

Summaries for African Tick-Bite Fever

Sources:
8Disease Ontology, 64Wikipedia, 33MalaCards
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Disease Ontology:8 A spotted fever that has material basis in rickettsia africae, which is transmitted by ticks (amblyomma hebraeum and amblyomma variegatum). the infection has symptom fever, has symptom eschar and has symptom maculopapular rash.

MalaCards: African Tick-Bite Fever, also known as rickettsia africae spotted fever, is related to boutonneuse fever and cutaneous leishmaniasis, and has symptoms including fever, eschar and maculopapular rash. An important gene associated with African Tick-Bite Fever is CCL5 (chemokine (C-C motif) ligand 5), and among its related pathways are Leishmaniasis and PEDF Induced Signaling. The compounds endotoxin and rolipram have been mentioned in the context of this disorder. Affiliated tissues include skin and endothelial, and related mouse phenotypes are digestive/alimentary and homeostasis/metabolism.

Wikipedia:64 African tick bite fever is a bacterial infection transmitted by the Amblyomma, Dermacentor or the... more...

Aliases & Classifications for African Tick-Bite Fever

Sources:
8Disease Ontology, 10DISEASES, 61UMLS
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Aliases & Descriptions:

african tick-bite fever 8 10
rickettsia africae spotted fever 8
south african tick-bite fever 8
african tick bite fever 61


External Ids:

Disease Ontology8 DOID:0050035

Related Diseases for African Tick-Bite Fever

Sources:
17GeneCards, 18GeneDecks
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Graphical network of the top 20 diseases related to African Tick-Bite Fever:



Diseases related to african tick-bite fever

Clinical Features for African Tick-Bite Fever

Sources:
8Disease Ontology
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Symptoms:

8
  • fever
  • eschar
  • maculopapular rash

Drugs & Therapeutics for African Tick-Bite Fever

Sources:
5CenterWatch, 42NIH Clinical Center, 6ClinicalTrials
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Approved drugs:

Search CenterWatch for African Tick-Bite Fever

Drug clinical trials:

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Search NIH Clinical Center for African Tick-Bite Fever

Search CenterWatch for African Tick-Bite Fever

Genetic Tests for African Tick-Bite Fever

Anatomical Context for African Tick-Bite Fever

Sources:
33MalaCards
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MalaCards organs/tissues related to African Tick-Bite Fever:

33
Skin, Endothelial

Animal Models for African Tick-Bite Fever or affiliated genes

Sources:
37MGI, 28inGenious Targeting Laboratory
See all sources

MGI Mouse Phenotypes related to African Tick-Bite Fever:

37
idDescriptionMGI Source AccessionScoreTop Affiliating Genes
1MP:00053817.7CCL3, IFNG, IL13, IL10, VWF
2MP:00053767.3SELE, VWF, IL10, IL13, CD40LG, IFNG
3MP:00053977.1SELE, CCL5, CCL3, IFNG, CD40LG, IL13
4MP:00053877.0CCL5, CCL3, IFNG, CD40LG, IL13, IL10
5MP:00053846.9CCL5, CCL3, IFNG, CD40LG, IL13, IL10

Publications for African Tick-Bite Fever

Sources:
51PubMed
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Articles related to African Tick-Bite Fever:

(show all 44)
idTitleAuthorsYear
1
The use of eschar swabs for the diagnosis of African tick-bite fever. (23141102)
2012
2
Cutaneous leishmaniasis and rickettsial African tick-bite fever: a combination of exotic traveler's diseases in the same patient. (22788813)
2012
3
Neurological picture. Internuclear ophthalmoplegia following African tick bite fever. (21421770)
2011
4
Risk factors for African tick-bite fever in rural central Africa. (21460018)
2011
5
African tick-bite fever: a new entity in the differential diagnosis of multiple eschars in travelers. Description of five cases imported from South Africa to Switzerland. (20233665)
2010
6
Relative chemokine and adhesion molecule expression in Mediterranean spotted fever and African tick bite fever. (19091423)
2009
7
Unusual location of an inoculation lesion in a traveler with African tick-bite fever returning from South Africa. (19930389)
2009
8
Tache noire in African tick bite fever. (19861601)
2009
9
Diagnosis of Queensland tick typhus and African tick bite fever by PCR of lesion swabs. (19523304)
2009
10
African tick bite Fever in a Taiwanese traveler returning from South Africa: molecular and serologic studies. (19861602)
2009
11
African tick bite fever in elderly patients: 8 cases in French tourists returning from South Africa. (18558881)
2008
12
African tick bite fever--papulovesicular exanthem with fever after staying in South Africa. (18021248)
2008
13
African tick bite fever. (18218581)
2008
14
Two cases of cellulitis in the course of African tick bite fever: a fortuitous association? (18503259)
2008
15
African tick bite fever in a returned traveler. (17939635)
2007
16
Tick bite fever and Q fever - a South African perspective. (18250937)
2007
17
African tick bite fever. (17067925)
2006
18
African tick bite fever: a not-so-uncommon illness in international travelers. (17043186)
2006
19
Histologic features and immunodetection of African tick-bite fever eschar. (17073080)
2006
20
Sub-acute neuropathy in patients with African tick bite fever. (16449002)
2006
21
Increased levels of soluble CD40L in African tick bite fever: possible involvement of TLRs in the pathogenic interaction between Rickettsia africae, endothelial cells, and platelets. (16888032)
2006
22
Cardiac involvement in a patient with clinical and serological evidence of African tick-bite fever. (16242016)
2005
23
African tick-bite fever in French travelers. (16422013)
2005
24
African tick-bite fever. (15301327)
2004
25
Comparison of immunofluorescence, Western blotting, and cross-adsorption assays for diagnosis of African tick bite fever. (15242958)
2004
26
African tick-bite fever: four cases among Swiss travelers returning from South Africa. (15541225)
2004
27
African tick bite fever in travelers to rural sub-Equatorial Africa. (12766836)
2003
28
Sequential changes in hematologic and biochemical parameters in African tick bite fever. (12925109)
2003
29
African tick bite fever: not a spotless rickettsiosis! (12582376)
2003
30
Systemic inflammatory responses in African tick-bite fever. (12696016)
2003
31
African tick bite fever. (12954562)
2003
32
Outbreak of African tick-bite fever in six Italian tourists returning from South Africa. (11939395)
2002
33
African tick-bite fever in South Africa. (12379945)
2002
34
Imported African tick bite fever: a case report. (10344666)
1999
35
African tick-bite fever imported into Norway: presentation of 8 cases. (10447320)
1999
36
African tick-bite fever among international travelers--Oregon, 1998. (9832471)
1998
37
African tick-bite fever. An imported spotless rickettsiosis. (8996049)
1997
38
African Tick-Bite Fever: A Case Report. (9815517)
1997
39
Rickettsia africae sp. nov., the etiological agent of African tick bite fever. (8934912)
1996
40
South African tick-bite fever complicated by severe encephalopathy. (1598654)
1992
41
African tick-bite fever: a new spotted fever group rickettsiosis under an old name. (1357393)
1992
42
Correlation of the distribution of Rickettsia conorii, microscopic lesions, and clinical features in South African tick bite fever. (3885774)
1985
43
South African tick-bite fever (1931-1981). (7036374)
1981
44
A method for increasing the infectivity of yolk-sac cultures of the rickettsiae of epidemic and murine typhus, and South African tick-bite fever. (20282007)
1946

Genetic Variations for African Tick-Bite Fever

Expression for genes affiliated with African Tick-Bite Fever

Sources:
1BioGPS, 15Gene Expression Omnibus DataSets
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Expression patterns in normal tissues for genes affiliated with African Tick-Bite Fever

Search GEO for disease gene expression data for African Tick-Bite Fever.

Pathways for genes affiliated with African Tick-Bite Fever

Sources:
30KEGG, 52QIAGEN, 38NCBI BioSystems Database, 53R&D Systems
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Pathways related to African Tick-Bite Fever according to GeneCards/GeneDecks:

(show all 15)
idSuper pathways (with members indented)ScoreTop Affiliating Genes
1
Hide members
9.8IL13, CD40LG
2
Hide members
9.6IL13, CCL3
39.5IL13, IFNG
4
Hide members
9.3CCL5, CCL3, IL13
59.2SELE, IL13, IFNG
69.0IL10, IL13, IFNG
79.0IFNG, IL13, IL10
89.0IFNG, IL13, IL10
99.0IFNG, IL10, SELE
10
Hide members
9.0IL10, CD40LG, IFNG
11
Hide members
8.8CCL5, CCL3, IL13, IL10
12
Hide members
8.8IL10, IFNG, CCL3
13
Hide members
8.6IL10, IL13, CD40LG, IFNG
14
Hide members
8.5CCL5, CCL3, IFNG, IL10
15
Hide members
8.2CCL5, CCL3, IFNG, IL13, IL10

Compounds for genes affiliated with African Tick-Bite Fever

Sources:
45Novoseek, 60Tocris Bioscience, 29IUPHAR, 50PharmGKB, 11DrugBank, 24HMDB
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Compounds related to African Tick-Bite Fever according to GeneCards/GeneDecks:

(show top 50)    (show all 145)
idCompoundScoreTop Affiliating Genes
1endotoxin4510.6SELE
2rolipram45 60 2912.4SELE
3cyclophosphamide45 50 1112.3VWF
4gamma globulin4510.2VWF
5prednisolone45 29 1112.1IL13, VWF
6dexamethasone45 50 29 1112.8CD40LG, CCL5, IL13
7aspartate459.7SELE, GPT, CD40LG
8pdtc459.7SELE, CCL5
9mycophenolic acid45 50 1111.5CD40LG, CCL5, IL13, SELE
10gm-csf45 2910.5IFNG, IL10, CCL5
11rantes459.4IFNG, CD40LG, CCL3
12fenofibrate45 50 1111.3GPT, SELE, CD40LG, CCL5
13fluticasone propionate45 50 60 1112.2SELE, IL13, IFNG, CCL5
14mip 1alpha459.2CCL3, CCL5, IL13, IL10
15ccl445 2910.2IL13, CCL3, CCL5, GPT
16alpha-galactosylceramide459.2IL13, IL10, IFNG
17mcp 1459.1CCL5, CCL3, IL10
18glatiramer acetate45 1110.1IFNG, IL13, CCL5, IL10
19il-12459.0CD40LG, IL13, IL10, IFNG
20okt3459.0IL10, CD40LG, SELE, IFNG
21aspirin45 50 29 2411.9VWF, IL13, CD40LG, SELE, CCL5
22rituximab45 50 1110.9CD40LG, IL13, IL10, VWF
23groalpha458.9IL10, SELE, IL13, CCL5, CCL3
24heparin45 29 11 2411.9CCL5, IL13, CCL3, CD40LG, SELE
25ifn-alpha458.8IL10, GPT, IL13, IFNG
26polyinosinic-polycytidylic acid458.8IL10, SELE, CCL3, IFNG
27atorvastatin45 50 29 11 2412.7SELE, GPT, VWF, IL10, CD40LG
28thyroxine45 249.7CD40LG, GPT, VWF, IL10, IL13
29thalidomide45 50 60 1111.7CD40LG, IFNG, IL13, IL10, CCL5
30allergens458.7IFNG, CD40LG, IL10, IL13
31cyclosporin a45 29 6010.7CCL3, IFNG, CD40LG, GPT, CCL5
32mycophenolate mofetil45 50 1110.6IFNG, CD40LG, IL10, GPT, SELE
33il 10458.6IL13, IFNG, CCL3, CCL5, IL10
34tarc458.6IFNG, CCL3, CCL5, IL10, IL13
35ccl345 299.6CCL3, IL13, IL10, CCL5, IFNG
36ivig458.5CD40LG, IL10, IFNG, GPT, VWF
37epinephrine45 11 2410.5CCL5, CD40LG, CCL3, SELE, VWF
38ribavirin45 50 1110.4IFNG, GPT, CCL3, IL10, CD40LG
39neopterin458.4IL10, CD40LG, IFNG, GPT, CCL3
40n acetylcysteine458.3CCL5, CD40LG, GPT, SELE, VWF
41ionomycin458.2IFNG, IL10, CCL5, IL13, CD40LG, CCL3
42sb 20358045 609.2IL13, IFNG, CCL3, CCL5, SELE, IL10
43tacrolimus45 50 1110.2CCL5, CCL3, IL13, IL10, GPT, IFNG
44lactate458.1VWF, IL13, CCL5, CD40LG, GPT, SELE
45alanine458.0CD40LG, CCL5, GPT, CCL3, SELE, VWF
46simvastatin45 50 60 29 11 2412.7CCL3, IFNG, IL10, VWF, GPT, SELE
47nitric oxide45 11 249.7IL13, CCL3, CCL5, IFNG, SELE, IL10
48histamine45 29 249.5SELE, CCL5, VWF, IL10, IL13, CD40LG
49vegf457.4SELE, IL13, VWF, CCL5, CCL3, IL10
50cysteine457.3IL13, CCL5, CCL3, IFNG, MTCP1, CD40LG

GO Terms for genes affiliated with African Tick-Bite Fever

Sources:
16Gene Ontology
See all sources

Cellular components related to African Tick-Bite Fever according to GeneCards/GeneDecks:

idNameGO IDScoreTop Affiliating Genes
1external side of plasma membraneGO:0098978.7VWF, IL13, CD40LG, IFNG
2extracellular spaceGO:0056157.2SELE, CCL5, CCL3, IFNG, CD40LG, IL13

Biological processes related to African Tick-Bite Fever according to GeneCards/GeneDecks:

(show all 21)
idNameGO IDScoreTop Affiliating Genes
1positive regulation of natural killer cell chemotaxisGO:200050310.0CCL3, CCL5
2eosinophil chemotaxisGO:04824510.0CCL5, CCL3
3negative regulation by host of viral transcriptionGO:0439229.9CCL3, CCL5
4macrophage chemotaxisGO:0482469.9CCL5, CCL3
5monocyte chemotaxisGO:0025489.9CCL3, CCL5
6B cell proliferationGO:0421009.9IL10, CD40LG
7cellular response to interferon-gammaGO:0713469.8CCL3, CCL5
8leukocyte cell-cell adhesionGO:0071599.8SELE, CD40LG, CCL5
9positive chemotaxisGO:0509189.8CCL3, CCL5
10positive regulation of calcium ion transportGO:0519289.7CCL3, CCL5
11lipopolysaccharide-mediated signaling pathwayGO:0316639.7CCL5, CCL3
12cellular response to interleukin-1GO:0713479.7CCL3, CCL5
13positive regulation of MHC class II biosynthetic processGO:0453489.6IL10, IFNG
14regulation of sensory perception of painGO:0519309.6IL10, CCL3
15positive regulation of interleukin-12 productionGO:0327359.6IFNG, CD40LG
16negative regulation of growth of symbiont in hostGO:0441309.6IL10, IFNG
17positive regulation of interleukin-1 beta secretionGO:0507189.6CCL3, IFNG
18cellular response to organic cyclic compoundGO:0714079.6CCL3, CCL5
19protein kinase B signaling cascadeGO:0434919.4CCL3, CCL5
20cell-cell signalingGO:0072679.1CCL5, CCL3, IL13, IL10
21inflammatory responseGO:0069548.4SELE, CCL5, CCL3, CD40LG, IL13, IL10

Molecular functions related to African Tick-Bite Fever according to GeneCards/GeneDecks:

idNameGO IDScoreTop Affiliating Genes
1CCR5 chemokine receptor bindingGO:0317309.7CCL3, CCL5
2chemoattractant activityGO:0420569.7CCL3, CCL5
3phospholipase activator activityGO:0160049.6CCL5, CCL3
4CCR1 chemokine receptor bindingGO:0317269.4CCL3, CCL5
5cytokine activityGO:0051258.7IL10, IL13, CD40LG, IFNG

Products for genes affiliated with African Tick-Bite Fever

  • Antibodies
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  • Lysates
  • Antibodies

Sources for African Tick-Bite Fever

3CDC
13ExPASy
14FMA
22GTR
23HGMD
24HMDB
25ICD10
26ICD10 via Orphanet
27ICD9CM
29IUPHAR
30KEGG
35MeSH
36MESH via Orphanet
37MGI
40NCIt
41NDF-RT
44NINDS
45Novoseek
47OMIM
48OMIM via Orphanet
51PubMed
52QIAGEN
58SNOMED-CT via Orphanet
61UMLS
62UMLS via Orphanet