MCID: AFR002
MIFTS: 50

African Tick-Bite Fever malady

Infectious diseases category
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Summaries for African Tick-Bite Fever

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8Disease Ontology, 65Wikipedia, 33MalaCards
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Disease Ontology:8 A spotted fever that has material basis in rickettsia africae, which is transmitted by ticks (amblyomma hebraeum and amblyomma variegatum). the infection has symptom fever, has symptom eschar and has symptom maculopapular rash.

MalaCards: African Tick-Bite Fever, also known as rickettsia africae spotted fever, is related to boutonneuse fever and cutaneous leishmaniasis, and has symptoms including fever, eschar and maculopapular rash. An important gene associated with African Tick-Bite Fever is CCL5 (chemokine (C-C motif) ligand 5), and among its related pathways are Cell adhesion Cell matrix glycoconjugates and Chemokine Superfamily: Human/Mouse Ligand-Receptor Interactions. The compounds mycophenolic acid and mcp 1 have been mentioned in the context of this disorder. Affiliated tissues include skin and endothelial, and related mouse phenotypes are respiratory system and no phenotypic analysis.

Wikipedia:65 African tick bite fever is a bacterial infection transmitted by the Amblyomma, Dermacentor or the... more...

Aliases & Classifications for African Tick-Bite Fever

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8Disease Ontology, 10DISEASES, 62UMLS
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Classifications:

Malacards categories (disease lists): (See all malacards categories)
Global: Infectious diseases


Aliases & Descriptions:

african tick-bite fever 8 10
rickettsia africae spotted fever 8
south african tick-bite fever 8
african tick bite fever 62


External Ids:

Disease Ontology8 DOID:0050035

Related Diseases for African Tick-Bite Fever

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17GeneCards, 18GeneDecks
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Diseases related to African Tick-Bite Fever via text searches within MalaCards or GeneCards/GeneDecks gene sharing:

(show top 50)    (show all 102)
idRelated DiseaseScoreTop Affiliating Genes
1boutonneuse fever31.0MTCP1
2cutaneous leishmaniasis30.6IL10, IFNG
3leishmaniasis30.5IFNG, IL10, IL13
4spotted fever10.5
5typhus10.5
6queensland tick typhus10.4
7internuclear ophthalmoplegia10.4
8cellulitis10.4
9exanthem10.4
10neuropathy10.4
11ophthalmoplegia10.4
12endotheliitis10.4
13mediterranean spotted fever10.4
14filariasis10.1IL13
15pustulosis palmaris et plantaris10.1SELE
16eosinophilic pneumonia10.1CCL5, IL13
17vernal keratoconjunctivitis10.1CCL5, IL13
18periapical granuloma10.1CCL3, CCL5
19encephalitis10.1CCL5, CCL3
20mast-cell leukemia10.1CCL3, CCL5
21respiratory failure10.1IL13, CCL5
22psoriatic arthritis10.1IL13, SELE
23pulmonary eosinophilia10.1CCL3, IL13
24alcoholic hepatitis10.1CCL3, CCL5
25dengue disease10.1CCL5, CCL3
26bullous pemphigoid10.1IL13, CCL5
27extrinsic allergic alveolitis10.1CCL5, CCL3
28rhinitis10.1CCL5, IL13
29interstitial lung disease10.1CCL5, CCL3
30pleural tuberculosis10.0IFNG, CCL3
31tropical spastic paraparesis10.0CCL3, IFNG
32immunodeficiency, common variable, 710.0IL10, IL13
33aspergillosis10.0CCL3, IFNG
34tuberculoid leprosy10.0IFNG, IL10
35behcet's disease10.0CCL3, SELE
36lepromatous leprosy10.0IFNG, IL10
37toxic shock syndrome10.0CCL3, IFNG
38visceral leishmaniasis10.0IFNG, IL10
39acute graft versus host disease10.0IL10, IFNG
40type 1 diabetes mellitus10.0IFNG, IL10
41lupus nephritis10.0CCL5, IL10
42bronchiolitis10.0CCL3, CCL5, IL13
43pulmonary disease, chronic obstructive10.0CCL3, CCL5, IL13
44peripheral vascular disease10.0VWF, SELE
45thrombotic thrombocytopenic purpura, acquired10.0VWF, SELE
46hepatitis b10.0IFNG, IL10
47cutaneous t cell lymphoma10.0IFNG, SELE
48dermatitis10.0SELE, IFNG, IL13
49lymphopenia10.0IFNG, IL10
50pulmonary sarcoidosis10.0IFNG, CCL5, CCL3

Graphical network of the top 20 diseases related to African Tick-Bite Fever:



Diseases related to african tick-bite fever

Symptoms for African Tick-Bite Fever

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8Disease Ontology
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Symptoms:

8
  • fever
  • eschar
  • maculopapular rash

Drugs & Therapeutics for African Tick-Bite Fever

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42NIH Clinical Center, 6ClinicalTrials
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Drug clinical trials:

Search ClinicalTrials for African Tick-Bite Fever

Search NIH Clinical Center for African Tick-Bite Fever

Genetic Tests for African Tick-Bite Fever

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Anatomical Context for African Tick-Bite Fever

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33MalaCards
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MalaCards organs/tissues related to African Tick-Bite Fever:

33
Skin, Endothelial

Animal Models for African Tick-Bite Fever or affiliated genes

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37MGI
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MGI Mouse Phenotypes related to African Tick-Bite Fever:

37
idDescriptionMGI Source AccessionScoreTop Affiliating Genes
1MP:00053888.6IL13, IL10, IFNG, SELE
2MP:00030128.2VWF, IFNG, IL10, IL13
3MP:00053818.1VWF, CCL3, IFNG, IL10, IL13
4MP:00053847.6VWF, SELE, CCL3, IFNG, IL10, IL13
5MP:00053767.6VWF, SELE, CCL3, IFNG, IL10, IL13
6MP:00107687.5VWF, SELE, CCL3, IFNG, IL10, IL13
7MP:00053977.4IL13, VWF, SELE, CCL3, CCL5, IFNG
8MP:00053877.4VWF, SELE, CCL3, CCL5, IFNG, IL10

Publications for African Tick-Bite Fever

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52PubMed
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Articles related to African Tick-Bite Fever:

(show all 43)
idTitleAuthorsYear
1
The use of eschar swabs for the diagnosis of African tick-bite fever. (23141102)
2012
2
Cutaneous leishmaniasis and rickettsial African tick-bite fever: a combination of exotic traveler's diseases in the same patient. (22788813)
2012
3
Neurological picture. Internuclear ophthalmoplegia following African tick bite fever. (21421770)
2011
4
Risk factors for African tick-bite fever in rural central Africa. (21460018)
2011
5
African tick-bite fever: a new entity in the differential diagnosis of multiple eschars in travelers. Description of five cases imported from South Africa to Switzerland. (20233665)
2010
6
Relative chemokine and adhesion molecule expression in Mediterranean spotted fever and African tick bite fever. (19091423)
2009
7
Unusual location of an inoculation lesion in a traveler with African tick-bite fever returning from South Africa. (19930389)
2009
8
Tache noire in African tick bite fever. (19861601)
2009
9
Diagnosis of Queensland tick typhus and African tick bite fever by PCR of lesion swabs. (19523304)
2009
10
African tick bite Fever in a Taiwanese traveler returning from South Africa: molecular and serologic studies. (19861602)
2009
11
African tick bite fever in elderly patients: 8 cases in French tourists returning from South Africa. (18558881)
2008
12
African tick bite fever--papulovesicular exanthem with fever after staying in South Africa. (18021248)
2008
13
African tick bite fever. (18218581)
2008
14
Two cases of cellulitis in the course of African tick bite fever: a fortuitous association? (18503259)
2008
15
African tick bite fever in a returned traveler. (17939635)
2007
16
African tick bite fever. (17067925)
2006
17
African tick bite fever: a not-so-uncommon illness in international travelers. (17043186)
2006
18
Histologic features and immunodetection of African tick-bite fever eschar. (17073080)
2006
19
Sub-acute neuropathy in patients with African tick bite fever. (16449002)
2006
20
Increased levels of soluble CD40L in African tick bite fever: possible involvement of TLRs in the pathogenic interaction between Rickettsia africae, endothelial cells, and platelets. (16888032)
2006
21
Cardiac involvement in a patient with clinical and serological evidence of African tick-bite fever. (16242016)
2005
22
African tick-bite fever in French travelers. (16422013)
2005
23
African tick-bite fever. (15301327)
2004
24
Comparison of immunofluorescence, Western blotting, and cross-adsorption assays for diagnosis of African tick bite fever. (15242958)
2004
25
African tick-bite fever: four cases among Swiss travelers returning from South Africa. (15541225)
2004
26
African tick bite fever in travelers to rural sub-Equatorial Africa. (12766836)
2003
27
Sequential changes in hematologic and biochemical parameters in African tick bite fever. (12925109)
2003
28
African tick bite fever: not a spotless rickettsiosis! (12582376)
2003
29
Systemic inflammatory responses in African tick-bite fever. (12696016)
2003
30
African tick bite fever. (12954562)
2003
31
Outbreak of African tick-bite fever in six Italian tourists returning from South Africa. (11939395)
2002
32
African tick-bite fever in South Africa. (12379945)
2002
33
Imported African tick bite fever: a case report. (10344666)
1999
34
African tick-bite fever imported into Norway: presentation of 8 cases. (10447320)
1999
35
African tick-bite fever among international travelers--Oregon, 1998. (9832471)
1998
36
African tick-bite fever. An imported spotless rickettsiosis. (8996049)
1997
37
African Tick-Bite Fever: A Case Report. (9815517)
1997
38
Rickettsia africae sp. nov., the etiological agent of African tick bite fever. (8934912)
1996
39
South African tick-bite fever complicated by severe encephalopathy. (1598654)
1992
40
African tick-bite fever: a new spotted fever group rickettsiosis under an old name. (1357393)
1992
41
Correlation of the distribution of Rickettsia conorii, microscopic lesions, and clinical features in South African tick bite fever. (3885774)
1985
42
South African tick-bite fever (1931-1981). (7036374)
1981
43
A method for increasing the infectivity of yolk-sac cultures of the rickettsiae of epidemic and murine typhus, and South African tick-bite fever. (20282007)
1946

Variations for African Tick-Bite Fever

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Expression for genes affiliated with African Tick-Bite Fever

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2BioGPS, 15Gene Expression Omnibus DataSets
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Expression patterns in normal tissues for genes affiliated with African Tick-Bite Fever

Search GEO for disease gene expression data for African Tick-Bite Fever.

Pathways for genes affiliated with African Tick-Bite Fever

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50PathCards, 60Thomson Reuters, 54R&D Systems, 55Reactome, 38NCBI BioSystems Database, 12EMD Millipore, 30KEGG, 53QIAGEN
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Pathways related to African Tick-Bite Fever according to GeneCards/GeneDecks:

(show all 24)
idSuper pathways (with members indented)ScoreTop Affiliating Genes
19.7CCL5, SELE
2
Show member pathways
9.6CCL3, CCL5
39.5IL13, IFNG
49.4SELE, IFNG
59.4CCL3, VWF
6
Show member pathways
IL27-mediated signaling events38
9.4IL10, IFNG
7
Show member pathways
9.1IL13, IFNG, CCL5
89.1IFNG, SELE, IL13
9
Show member pathways
Type III interferon signaling38
9.0IL10, IL13, IFNG
10
Show member pathways
9.0IL13, IL10, IFNG
119.0IFNG, IL10, IL13
129.0IFNG, IL10, IL13
13
Show member pathways
9.0IL13, IL10, IFNG
149.0IL13, IL10, IFNG
159.0SELE, IL10, IFNG
169.0IL10, IFNG, SELE
179.0IFNG, CCL5, CCL3
18
Show member pathways
8.9IL10, CCL3, IFNG
19
Show member pathways
8.8CCL3, CCL5, IL10, IL13
20
Show member pathways
8.8CCL3, IL13, IL10, CCL5
21
Show member pathways
8.8IL13, IL10, CCL5, CCL3
22
Show member pathways
Toll-like receptor signaling pathway38
Regulation of toll-like receptor signaling pathway38
8.5IFNG, IL10, CCL3, CCL5
23
Show member pathways
8.2CCL3, CCL5, IFNG, IL10, IL13
24
Show member pathways
8.2CCL5, CCL3, IFNG, IL13, IL10

Compounds for genes affiliated with African Tick-Bite Fever

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45Novoseek, 51PharmGKB, 11DrugBank, 61Tocris Bioscience, 24HMDB, 29IUPHAR, 3BitterDB
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Compounds related to African Tick-Bite Fever according to GeneCards/GeneDecks:

(show top 50)    (show all 141)
idCompoundScoreTop Affiliating Genes
1mycophenolic acid45 51 1111.6IL13, SELE, CCL5
2mcp 1459.5CCL3, CCL5, IL10
3mdms459.5CCL3, CCL5, IL10
4amphotericin b459.4IL13, IFNG, CCL5
5alpha-galactosylceramide459.4IL13, IFNG, IL10
6il-12459.3IL10, IFNG, IL13
7indoleamine459.3IFNG, IL13, IL10
8mip 1alpha459.2IL10, IL13, CCL3, CCL5
9polymyxin b459.2IL10, IFNG, SELE
10okt3459.1IL10, IFNG, SELE
11fluticasone propionate45 51 61 1112.1CCL5, IL13, IFNG, SELE
12glatiramer acetate45 1110.1IL10, CCL5, IL13, IFNG
13lipoteichoic acid459.1CCL3, IL10, SELE
14indinavir45 51 1111.1CCL5, CCL3, IFNG
15thalidomide45 51 61 1112.0IL13, IL10, IFNG, CCL5
16homocysteine45 2410.0VWF, SELE, CCL3, CCL5
17triptolide459.0CCL3, CCL5, IFNG
18rolipram45 61 2911.0IFNG, IL10, IL13, SELE
19pdtc458.9CCL5, CCL3, SELE, IFNG
20calcitriol45 61 24 1111.9IL10, IFNG, CCL5, IL13
21polyinosinic-polycytidylic acid458.9SELE, IL10, CCL3, IFNG
22budesonide45 51 1110.8IL13, CCL5, IFNG
23groalpha458.8IL13, SELE, CCL3, CCL5, IL10
24aspirin45 51 29 2411.7SELE, VWF, IL13, CCL5
25ly294002458.7SELE, CCL5, CCL3, IL13, IL10
26guanine45 24 1110.7IL10, SELE, VWF, CCL3
27lactate458.6CCL3, CCL5, IL13, SELE, VWF
28gm-csf45 299.6IFNG, IL10, CCL5, IL13, CCL3
29il 10458.6IL13, CCL3, IL10, IFNG, CCL5
30tarc458.6IL10, IFNG, IL13, CCL5, CCL3
31cyclophosphamide45 51 1110.6IL13, CCL3, IL10, SELE, VWF
32ccl345 299.6CCL5, CCL3, IFNG, IL10, IL13
33hydrocortisone45 3 61 1111.6CCL5, IFNG, IL10, CCL3, IL13
34heparin45 29 24 1111.6IL13, SELE, VWF, CCL3, CCL5
35ionomycin458.6CCL3, CCL5, IFNG, IL10, IL13
36tacrolimus45 51 1110.5IL13, IL10, IFNG, CCL5, CCL3
37aspartate458.5IL10, VWF, SELE, CCL3, IL13
38prednisolone45 29 1110.4VWF, CCL3, IFNG, IL10, IL13
39endotoxin458.2CCL5, CCL3, IFNG, IL10, IL13, SELE
40rantes458.2SELE, CCL5, IL13, IL10, IFNG, CCL3
41sb 20358045 619.2SELE, CCL5, IFNG, IL10, IL13, CCL3
42pge2458.1IL10, SELE, CCL3, IL13, CCL5, IFNG
43cycloheximide458.1SELE, IL10, IFNG, CCL5, CCL3, IL13
44simvastatin45 51 61 29 24 1113.0IL10, VWF, SELE, CCL3, CCL5, IFNG
45cyclosporin a45 29 6110.0CCL5, IFNG, CCL3, VWF, IL10, IL13
46dexamethasone45 51 29 1111.0IL13, IL10, IFNG, CCL5, CCL3, VWF
47histamine45 29 249.7VWF, SELE, CCL3, CCL5, IFNG, IL10
48vegf457.6IL13, CCL3, VWF, SELE, CCL5, IFNG
49nitric oxide45 24 119.6IL13, VWF, SELE, CCL3, IFNG, CCL5
50cysteine457.6VWF, CCL3, CCL5, IL13, MTCP1, IFNG

GO Terms for genes affiliated with African Tick-Bite Fever

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16Gene Ontology
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Cellular components related to African Tick-Bite Fever according to GeneCards/GeneDecks:

idNameGO IDScoreTop Affiliating Genes
1external side of plasma membraneGO:0098979.0IL13, IFNG, VWF
2extracellular regionGO:0055767.8IL13, VWF, CCL3, CCL5, IFNG
3extracellular spaceGO:0056157.6IFNG, SELE, CCL3, CCL5, IL13, IL10

Biological processes related to African Tick-Bite Fever according to GeneCards/GeneDecks:

(show all 32)
idNameGO IDScoreTop Affiliating Genes
1leukocyte cell-cell adhesionGO:00715910.0SELE, CCL5
2positive regulation of natural killer cell chemotaxisGO:200050310.0CCL3, CCL5
3eosinophil chemotaxisGO:04824510.0CCL3, CCL5
4negative regulation by host of viral transcriptionGO:04392210.0CCL3, CCL5
5macrophage chemotaxisGO:04824610.0CCL3, CCL5
6monocyte chemotaxisGO:00254810.0CCL5, CCL3
7positive regulation of smooth muscle cell proliferationGO:04866110.0CCL5, IL13
8cellular response to interferon-gammaGO:07134610.0CCL3, CCL5
9positive regulation of calcium ion transportGO:0519289.9CCL5, CCL3
10positive chemotaxisGO:0509189.9CCL3, CCL5
11lipopolysaccharide-mediated signaling pathwayGO:0316639.9CCL3, CCL5
12protein kinase B signalingGO:0434919.9CCL5, CCL3
13cellular response to interleukin-1GO:0713479.9CCL5, CCL3
14cellular response to organic cyclic compoundGO:0714079.9CCL3, CCL5
15regulation of sensory perception of painGO:0519309.8IL10, CCL3
16positive regulation of MHC class II biosynthetic processGO:0453489.8IL10, IFNG
17calcium-mediated signalingGO:0197229.8SELE, CCL3
18negative regulation of growth of symbiont in hostGO:0441309.8IL10, IFNG
19positive regulation of cell adhesionGO:0457859.8IFNG, CCL5
20cellular response to tumor necrosis factorGO:0713569.8CCL3, CCL5
21response to toxic substanceGO:0096369.7CCL5, CCL3
22positive regulation of interleukin-1 beta secretionGO:0507189.7IFNG, CCL3
23positive regulation of T cell proliferationGO:0421029.7IFNG, CCL5
24MAPK cascadeGO:0001659.7CCL3, CCL5
25cellular calcium ion homeostasisGO:0068749.6CCL3, CCL5
26positive regulation of tumor necrosis factor productionGO:0327609.6CCL3, IFNG
27neutrophil chemotaxisGO:0305939.6IFNG, CCL3
28exocytosisGO:0068879.5CCL3, CCL5
29cellular response to lipopolysaccharideGO:0712229.4IFNG, IL10
30calcium ion transportGO:0068169.3CCL3, CCL5
31cell-cell signalingGO:0072679.2IL13, IL10, CCL5, CCL3
32inflammatory responseGO:0069548.8IL13, SELE, CCL3, CCL5, IL10

Molecular functions related to African Tick-Bite Fever according to GeneCards/GeneDecks:

idNameGO IDScoreTop Affiliating Genes
1phospholipase activator activityGO:0160049.7CCL5, CCL3
2CCR1 chemokine receptor bindingGO:0317269.7CCL5, CCL3
3CCR5 chemokine receptor bindingGO:0317309.6CCL5, CCL3
4chemokine activityGO:0080099.6CCL5, CCL3
5chemoattractant activityGO:0420569.3CCL5, CCL3
6cytokine activityGO:0051258.9IFNG, IL10, IL13

Products for genes affiliated with African Tick-Bite Fever

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Sources for African Tick-Bite Fever

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4CDC
13ExPASy
14FMA
22GTR
23HGMD
24HMDB
25ICD10
26ICD10 via Orphanet
27ICD9CM
29IUPHAR
30KEGG
35MeSH
36MESH via Orphanet
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40NCIt
41NDF-RT
44NINDS
45Novoseek
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48OMIM via Orphanet
52PubMed
53QIAGEN
59SNOMED-CT via Orphanet
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