MCID: AFR002
MIFTS: 45

African Tick-Bite Fever malady

Category: Infectious diseases

Aliases & Classifications for African Tick-Bite Fever

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Aliases & Descriptions for African Tick-Bite Fever:

Name: African Tick-Bite Fever 10 12
Rickettsia Africae Spotted Fever 10
 
South African Tick-Bite Fever 10
African Tick Bite Fever 65

Classifications:



External Ids:

Disease Ontology10 DOID:0050035
UMLS65 C1320317

Summaries for African Tick-Bite Fever

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Disease Ontology:10 A spotted fever that has material basis in Rickettsia africae, which is transmitted by ticks (Amblyomma hebraeum and Amblyomma variegatum). The infection has symptom fever, has symptom eschar and has symptom maculopapular rash.

MalaCards based summary: African Tick-Bite Fever, also known as rickettsia africae spotted fever, is related to cutaneous leishmaniasis and boutonneuse fever, and has symptoms including fever, eschar and maculopapular rash. An important gene associated with African Tick-Bite Fever is CD40LG (CD40 Ligand), and among its related pathways are Th2 Differentiation Pathway and OX40 Pathway. Affiliated tissues include skin, liver and bone, and related mouse phenotypes are respiratory system and reproductive system.

Wikipedia:68 African tick bite fever is a bacterial infection transmitted by the Amblyomma, Dermacentor or the... more...

Related Diseases for African Tick-Bite Fever

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Diseases related to African Tick-Bite Fever via text searches within MalaCards or GeneCards Suite gene sharing:

(show top 50)    (show all 159)
idRelated DiseaseScoreTop Affiliating Genes
1cutaneous leishmaniasis30.3IFNG, IL10, TLR4
2boutonneuse fever11.9
3beriberi10.8CD40LG, IFNG
4oropouche fever10.8CD40LG, IL10
5cycloplegia10.7IFNG, IL10
6proliferative glomerulonephritis10.7CD40LG, CXCL8
7bacillary angiomatosis10.7CD40LG, IFNG
8louping ill10.7CD40LG, IFNG, IL10
9b cell deficiency10.7CD40LG, IFNG, IL10
10cow milk allergy10.7IFNG, IL10, IL13
11cervix melanoma10.7CD40LG, GPT, IFNG
12blastomycosis10.6CD40LG, IFNG, IL10
13vernal conjunctivitis10.6CD40LG, IFNG, IL10
14idiopathic cd4-positive t-lymphocytopenia10.6IL10, IL13
15primary progressive multiple sclerosis10.6CD40LG, IFNG, IL10
16hodgkin's lymphoma, nodular sclerosis10.6CD40LG, IL10, IL13
17dysgammaglobulinemia10.6CD40LG, IL10
18wissler's syndrome10.6IFNG, IL10, IL13
19food allergy10.6IFNG, IL10, SELE
20limited scleroderma10.6CD40LG, IFNG, IL10
21peritoneal cystic mesothelioma10.6CXCL8, IFNG, IL10
22peripheral retinal degeneration10.6CXCL8, IFNG, IL10
23blackwater fever10.5IFNG, IL10, SELE
24temporal lobe epilepsy10.5CD40LG, IFNG, SELE
25pneumocystosis10.5CD40LG, IFNG, IL10
26hydronephrosis10.5CCL5, IFNG, IL10
27narcissistic personality disorder10.5CD40LG, CXCL8, TLR4
28blue toe syndrome10.5CD40LG, CXCL8, TLR4
29lymph node cancer10.5TLR2, TLR4
30vagus nerve neoplasm10.5CD40LG, IFNG, IL10, SELE
31uterine corpus epithelioid leiomyoma10.5CD40LG, IFNG, IL10, IL13
32aniseikonia10.5CD40LG, IL10, TLR2
33liver lipoma10.5CXCL8, IFNG, IL10
34hemorrhagic proctocolitis10.5CD40LG, GPT, IFNG, IL10
35orbital plasma cell granuloma10.5CCL5, IFNG, IL13
36abdominal tuberculosis10.5IFNG, IL10, TLR2
37tethered spinal cord syndrome10.5IFNG, IL10, TLR2
38lateral sclerosis10.5CD40LG, IL10, TLR2
39rumination disorder10.4CD40LG, TLR2, TLR4
40capillary hemangioma10.4CD40LG, IFNG, IL13, SELE
41xanthogranulomatous pyelonephritis10.4CXCL8, IL10, TLR4
42temporal arteritis10.4CD40LG, TLR2, TLR4
43alcoholic liver cirrhosis10.4CXCL8, GPT, IL10
44angioid streaks of choroid10.4IFNG, TLR2, TLR4
45social phobia10.4CD40LG, TLR2, TLR4
46funisitis10.4CXCL8, IL10, TLR4
47hypoglycemic coma10.4CXCL8, IL10, TLR4
48mycobacterium abscessus10.4CCL5, CXCL8, IL10
49dentin dysplasia10.4CD40LG, CXCL8, IFNG, IL10
50common cold10.4CD40LG, TLR2, TLR4

Graphical network of the top 20 diseases related to African Tick-Bite Fever:



Diseases related to african tick-bite fever

Symptoms for African Tick-Bite Fever

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Symptoms:

 10
  • fever
  • eschar
  • maculopapular rash

Drugs & Therapeutics for African Tick-Bite Fever

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Interventional clinical trials:

Search ClinicalTrials, NIH Clinical Center for African Tick-Bite Fever

Genetic Tests for African Tick-Bite Fever

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Anatomical Context for African Tick-Bite Fever

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MalaCards organs/tissues related to African Tick-Bite Fever:

33
Skin, Liver, Bone, Thyroid, Colon, T cells, B cells

Animal Models for African Tick-Bite Fever or affiliated genes

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MGI Mouse Phenotypes related to African Tick-Bite Fever:

38
idDescriptionMGI Source AccessionScoreTop Affiliating Genes
1MP:00053888.8IFNG, IL10, IL13, SELE, THBD, TLR2
2MP:00053897.9CD40LG, GGT1, IFNG, IL10, IL13, IL15
3MP:00107717.8CD40LG, GGT1, IFNG, IL10, IL13, SELE
4MP:00053857.1ADRA2A, CD40LG, CX3CL1, IFNG, IL10, IL15
5MP:00053766.8ADRA2A, CD40LG, CX3CL1, GGT1, IFNG, IL10
6MP:00053975.8CCL5, CD40LG, CX3CL1, GGT1, GPT, IFNG
7MP:00053875.8CCL5, CD40LG, CX3CL1, GGT1, IFNG, IL10

Publications for African Tick-Bite Fever

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Articles related to African Tick-Bite Fever:

(show all 48)
idTitleAuthorsYear
1
First case of imported African tick-bite fever in Poland - Case report. (26403104)
2015
2
Images in clinical medicine: African tick-bite fever after a game-hunting expedition. (25738687)
2015
3
African Tick-Bite Fever in a Returning Traveler. (25795527)
2015
4
A family with African tick bite fever. (25886872)
2015
5
Case report of African tick-bite fever from Poland. (24494003)
2013
6
The use of eschar swabs for the diagnosis of African tick-bite fever. (23141102)
2012
7
Cutaneous leishmaniasis and rickettsial African tick-bite fever: a combination of exotic traveler's diseases in the same patient. (22788813)
2012
8
Neurological picture. Internuclear ophthalmoplegia following African tick bite fever. (21421770)
2011
9
Risk factors for African tick-bite fever in rural central Africa. (21460018)
2011
10
African tick-bite fever: a new entity in the differential diagnosis of multiple eschars in travelers. Description of five cases imported from South Africa to Switzerland. (20233665)
2010
11
Relative chemokine and adhesion molecule expression in Mediterranean spotted fever and African tick bite fever. (19091423)
2009
12
Unusual location of an inoculation lesion in a traveler with African tick-bite fever returning from South Africa. (19930389)
2009
13
Tache noire in African tick bite fever. (19861601)
2009
14
Diagnosis of Queensland tick typhus and African tick bite fever by PCR of lesion swabs. (19523304)
2009
15
African tick bite Fever in a Taiwanese traveler returning from South Africa: molecular and serologic studies. (19861602)
2009
16
African tick bite fever in elderly patients: 8 cases in French tourists returning from South Africa. (18558881)
2008
17
African tick bite fever--papulovesicular exanthem with fever after staying in South Africa. (18021248)
2008
18
African tick bite fever. (18218581)
2008
19
Two cases of cellulitis in the course of African tick bite fever: a fortuitous association? (18503259)
2008
20
African tick bite fever in a returned traveler. (17939635)
2007
21
African tick bite fever. (17067925)
2006
22
African tick bite fever: a not-so-uncommon illness in international travelers. (17043186)
2006
23
Histologic features and immunodetection of African tick-bite fever eschar. (17073080)
2006
24
Sub-acute neuropathy in patients with African tick bite fever. (16449002)
2006
25
Increased levels of soluble CD40L in African tick bite fever: possible involvement of TLRs in the pathogenic interaction between Rickettsia africae, endothelial cells, and platelets. (16888032)
2006
26
Cardiac involvement in a patient with clinical and serological evidence of African tick-bite fever. (16242016)
2005
27
African tick-bite fever in French travelers. (16422013)
2005
28
African tick-bite fever. (15301327)
2004
29
Comparison of immunofluorescence, Western blotting, and cross-adsorption assays for diagnosis of African tick bite fever. (15242958)
2004
30
African tick-bite fever: four cases among Swiss travelers returning from South Africa. (15541225)
2004
31
African tick bite fever in travelers to rural sub-Equatorial Africa. (12766836)
2003
32
Sequential changes in hematologic and biochemical parameters in African tick bite fever. (12925109)
2003
33
African tick bite fever: not a spotless rickettsiosis! (12582376)
2003
34
Systemic inflammatory responses in African tick-bite fever. (12696016)
2003
35
African tick bite fever. (12954562)
2003
36
Outbreak of African tick-bite fever in six Italian tourists returning from South Africa. (11939395)
2002
37
African tick-bite fever in South Africa. (12379945)
2002
38
Imported African tick bite fever: a case report. (10344666)
1999
39
African tick-bite fever imported into Norway: presentation of 8 cases. (10447320)
1999
40
African tick-bite fever among international travelers--Oregon, 1998. (9832471)
1998
41
African tick-bite fever. An imported spotless rickettsiosis. (8996049)
1997
42
African Tick-Bite Fever: A Case Report. (9815517)
1997
43
Rickettsia africae sp. nov., the etiological agent of African tick bite fever. (8934912)
1996
44
South African tick-bite fever complicated by severe encephalopathy. (1598654)
1992
45
African tick-bite fever: a new spotted fever group rickettsiosis under an old name. (1357393)
1992
46
Correlation of the distribution of Rickettsia conorii, microscopic lesions, and clinical features in South African tick bite fever. (3885774)
1985
47
South African tick-bite fever (1931-1981). (7036374)
1981
48
A method for increasing the infectivity of yolk-sac cultures of the rickettsiae of epidemic and murine typhus, and South African tick-bite fever. (20282007)
1946

Variations for African Tick-Bite Fever

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Expression for genes affiliated with African Tick-Bite Fever

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Search GEO for disease gene expression data for African Tick-Bite Fever.

Pathways for genes affiliated with African Tick-Bite Fever

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Pathways related to African Tick-Bite Fever according to GeneCards Suite gene sharing:

(show all 36)
idSuper pathwaysScoreTop Affiliating Genes
19.8IFNG, IL10, IL13
29.8IFNG, IL10, IL13
39.8IFNG, IL10, SELE
4
Show member pathways
9.7CD40LG, CXCL8, IFNG
59.7CXCL8, IFNG, SELE
69.7IFNG, IL10, THBD
79.7CD40LG, CXCL8, TLR4
89.6CXCL8, IL10, TLR4
99.6CXCL8, SELE, THBD
10
Show member pathways
9.6IFNG, TLR2, TLR4
119.6IFNG, TLR2, TLR4
129.5CXCL8, IFNG, IL13, SELE
139.5CD40LG, CX3CL1, TLR4
149.4CXCL8, TLR2, TLR4
159.3CD40LG, IL10, TLR2, TLR4
16
Show member pathways
9.3IFNG, IL10, TLR2, TLR4
179.3IFNG, IL10, TLR2, TLR4
189.3IFNG, IL10, IL13, IL15
19
Show member pathways
9.3IFNG, IL10, IL13, IL15
20
Show member pathways
9.2CXCL8, IFNG, TLR2, TLR4
21
Show member pathways
9.1CD40LG, IFNG, IL10, TLR2, TLR4
22
Show member pathways
9.0CCL3, CXCL8, IFNG, TLR4
239.0CXCL8, IFNG, IL10, TLR2, TLR4
24
Show member pathways
9.0CXCL8, IFNG, IL10, IL13, IL15
25
Show member pathways
8.9CCL3, IFNG, IL10, IL15
268.8CCL5, CX3CL1, IL15, SELE
278.7CCL3, IFNG, IL10, IL13, IL15
28
Show member pathways
8.6CCL3, CCL5, CX3CL1, CXCL8
298.6CD40LG, CXCL8, IFNG, IL10, SELE, TLR2
30
Show member pathways
8.4CD40LG, IFNG, IL10, IL13, IL15, TLR2
31
Show member pathways
8.1CCL5, CXCL8, IFNG, IL13, IL15, TLR2
32
Show member pathways
8.0CCL3, CCL5, CXCL8, IFNG, IL10, TLR2
337.7CCL3, CCL5, CXCL8, IFNG, IL15, TLR2
34
Show member pathways
7.5CCL3, CCL5, CD40LG, CX3CL1, CXCL8, IL10
35
Show member pathways
6.9CCL3, CCL5, CD40LG, CX3CL1, CXCL8, IFNG
36
Show member pathways
6.7CCL3, CCL5, CD40LG, CX3CL1, CXCL8, IL10

GO Terms for genes affiliated with African Tick-Bite Fever

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Cellular components related to African Tick-Bite Fever according to GeneCards Suite gene sharing:

idNameGO IDScoreTop Affiliating Genes
1external side of plasma membraneGO:00098979.8CD40LG, IL13, TLR4

Biological processes related to African Tick-Bite Fever according to GeneCards Suite gene sharing:

(show all 45)
idNameGO IDScoreTop Affiliating Genes
1defense response to protozoanGO:004283210.7IFNG, IL10
2positive regulation of membrane protein ectodomain proteolysisGO:005104410.7ADRA2A, IFNG
3negative regulation of interleukin-17 productionGO:003270010.7IFNG, TLR4
4positive regulation of interleukin-12 biosynthetic processGO:004508410.7IFNG, TLR4
5negative regulation of growth of symbiont in hostGO:004413010.7IFNG, IL10
6leukocyte cell-cell adhesionGO:000715910.6CCL5, CD40LG
7positive regulation of interleukin-10 productionGO:003273310.5CD40LG, TLR4
8cellular response to cytokine stimulusGO:007134510.5CCL5, IL13
9positive regulation of chemokine productionGO:003272210.5TLR2, TLR4
10neutrophil activationGO:004211910.5CCL5, CXCL8
11positive regulation of nitric-oxide synthase biosynthetic processGO:005177010.4TLR2, TLR4
12I-kappaB phosphorylationGO:000725210.4TLR2, TLR4
13positive regulation of osteoclast differentiationGO:004567210.4CCL5, IFNG
14negative regulation of G-protein coupled receptor protein signaling pathwayGO:004574410.4CCL5, CXCL8
15microglial cell activationGO:000177410.2CX3CL1, IL13
16positive regulation of MHC class II biosynthetic processGO:004534810.2IFNG, IL10, TLR4
17positive regulation of macrophage chemotaxisGO:001075910.2CCL5, CX3CL1
18positive regulation of interleukin-12 productionGO:003273510.2IFNG, TLR2, TLR4
19positive regulation of tumor necrosis factor productionGO:003276010.2IFNG, TLR2, TLR4
20cellular response to lipoteichoic acidGO:007122310.2TLR2, TLR4
21positive regulation of natural killer cell chemotaxisGO:200050310.1CCL3, CCL5
22negative regulation of osteoclast differentiationGO:004567110.1CCL3, TLR4
23eosinophil chemotaxisGO:004824510.1CCL3, CCL5
24response to cholesterolGO:007072310.1CCL3, CCL5
25protein kinase B signalingGO:004349110.0CCL3, CCL5
26movement of cell or subcellular componentGO:000692810.0ADRA2A, CXCL8, IFNG, IL13
27macrophage chemotaxisGO:004824610.0CCL3, CX3CL1
28positive regulation of cell adhesionGO:00457859.9CCL5, CX3CL1, IFNG
29neutrophil chemotaxisGO:00305939.9CX3CL1, CXCL8, IFNG
30positive regulation of smooth muscle cell proliferationGO:00486619.8CCL5, CX3CL1, IL13
31defense response to bacteriumGO:00427429.8IFNG, IL10, TLR4
32cellular response to lipopolysaccharideGO:00712229.5CCL5, CXCL8, IFNG, TLR4
33response to lipopolysaccharideGO:00324969.4CCL5, IL10, IL13, SELE
34monocyte chemotaxisGO:00025489.3CCL3, CCL5, CX3CL1
35cellular response to interferon-gammaGO:00713469.3CCL3, CCL5, CX3CL1
36agingGO:00075689.2CCL5, CX3CL1, IL10, IL15
37lipopolysaccharide-mediated signaling pathwayGO:00316639.2CCL3, CCL5, TLR2, TLR4
38inflammatory responseGO:00069549.1CCL5, CX3CL1, IL10, IL15
39cellular response to tumor necrosis factorGO:00713569.1CCL3, CX3CL1, CXCL8
40cell-cell signalingGO:00072678.8CCL3, CCL5, IL10, IL13, IL15
41positive regulation of gene expressionGO:00106288.7CCL3, CCL5, IFNG, TLR4
42signal transductionGO:00071658.4ADRA2A, CXCL8, IL13, IL15, TLR2, TLR4
43G-protein coupled receptor signaling pathwayGO:00071868.3ADRA2A, CCL3, CCL5, CX3CL1, CXCL8
44positive regulation of inflammatory responseGO:00507298.1CCL3, CCL5, CX3CL1, IL15, TLR2, TLR4
45immune responseGO:00069557.0CCL3, CCL5, CX3CL1, CXCL8, IFNG, IL10

Sources for African Tick-Bite Fever

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2CDC
14ExPASy
15FDA
16FMA
24GTR
25HGMD
26HMDB
27ICD10
28ICD10 via Orphanet
29ICD9CM
30IUPHAR
31KEGG
34MedGen
36MeSH
37MESH via Orphanet
38MGI
41NCI
42NCIt
43NDF-RT
46NINDS
47Novoseek
49OMIM
50OMIM via Orphanet
54PubMed
55QIAGEN
60SNOMED-CT via Orphanet
64Tumor Gene Family of Databases
65UMLS
66UMLS via Orphanet