MCID: AFR002
MIFTS: 33

African Tick-Bite Fever malady

Categories: Infectious diseases

Aliases & Classifications for African Tick-Bite Fever

Aliases & Descriptions for African Tick-Bite Fever:

Name: African Tick-Bite Fever 12 14
Rickettsia Africae Spotted Fever 12
South African Tick-Bite Fever 12
African Tick Bite Fever 69

Classifications:



External Ids:

Disease Ontology 12 DOID:0050035

Summaries for African Tick-Bite Fever

Disease Ontology : 12 A spotted fever that has material basis in Rickettsia africae, which is transmitted_by ticks (Amblyomma hebraeum and Amblyomma variegatum). The infection has symptom fever, has symptom eschar and has symptom maculopapular rash.

MalaCards based summary : African Tick-Bite Fever, also known as rickettsia africae spotted fever, is related to boutonneuse fever and centronuclear myopathy 5, and has symptoms including fever, eschar and maculopapular rash. An important gene associated with African Tick-Bite Fever is CD40LG (CD40 Ligand), and among its related pathways/superpathways are Cytokine Signaling in Immune system and Allograft rejection. Affiliated tissues include endothelial, and related phenotypes are hematopoietic system and immune system

Wikipedia : 71 African tick bite fever (ATBF) is a disease caused by the bacterium Rickettsia africae in sub-Saharan... more...

Related Diseases for African Tick-Bite Fever

Diseases related to African Tick-Bite Fever via text searches within MalaCards or GeneCards Suite gene sharing:

(show top 50) (show all 126)
id Related Disease Score Top Affiliating Genes
1 boutonneuse fever 12.0
2 centronuclear myopathy 5 10.2 CD40LG IFNG
3 conduct disorder 10.2 CD40LG IFNG
4 pancreatic signet ring cell adenocarcinoma 10.2 CD40LG IFNG
5 tularemia 10.2 CD40LG IFNG
6 intravascular angioleiomyoma 10.2 CD40LG IL13
7 oral cavity cancer 10.2 CD40LG IFNG
8 central nervous system origin vertigo 10.2 CD40LG IFNG
9 hereditary alpha tryptasemia syndrome 10.2 CD40LG IFNG
10 rickettsialpox 10.2 CD40LG IFNG
11 benign deep fibrous histiocytoma 10.2 CD40LG IFNG
12 hyperlucent lung 10.2 CD40LG IFNG
13 plummer's disease 10.2 CD40LG IFNG
14 oropharynx cancer 10.2 CD40LG IFNG
15 crustacean allergy 10.2 IFNG IL13
16 spastic diplegia 10.2 IFNG IL13
17 acute gonococcal prostatitis 10.2 IFNG IL13
18 disease of mental health 10.2 CD40LG IFNG
19 myofibroma 10.2 IFNG IL13
20 malignant oculomotor nerve tumor 10.1 IFNG IL13
21 proximal symphalangism 10.1 CD40LG IFNG
22 autoimmune disease of skin and connective tissue 10.1 CD40LG IFNG
23 myiasis 10.1 CD40LG IFNG
24 heart conduction disease 10.1 CD40LG IFNG
25 motor peripheral neuropathy 10.1 CD40LG IFNG
26 tonsil cancer 10.1 CD40LG SELE
27 depressed scar 10.1 CD40LG IFNG
28 actinic keratosis 10.1 CD40LG IL13
29 czech dysplasia 10.1 CD40LG SELE
30 dermatomycosis 10.1 CD40LG SELE
31 hydrophthalmos 10.1 IFNG IL13
32 loiasis 10.1 IFNG IL13
33 powassan encephalitis 10.1 CD40LG SELE
34 xanthogranulomatous cholecystitis 10.1 CD40LG IL13
35 dracunculiasis 10.1 CD40LG SELE
36 anterior foramen magnum meningioma 10.1 CD40LG IFNG
37 radial hypoplasia, triphalangeal thumbs and hypospadias 10.1 CD40LG SELE
38 urethral intrinsic sphincter deficiency 10.1 IFNG SELE
39 acute dacryoadenitis 10.1 CD40LG IL13
40 rosacea 10.1 IFNG SELE
41 hallucinogen dependence 10.1 CD40LG IFNG
42 chronic thromboembolic pulmonary hypertension 10.1 IFNG SELE
43 tracheitis 10.1 IFNG IL13
44 spotted fever 10.1
45 paratyphoid fever 10.1 IFNG IL13
46 childhood choriocarcinoma of the testis 10.1 CD40LG IL13
47 thyroid hyalinizing trabecular adenoma 10.1 IFNG IL13
48 keratomalacia 10.1 CD40LG IFNG
49 dengue hemorrhagic fever 10.1 IFNG IL13
50 nonspecific interstitial pneumonia 10.1 CD40LG IFNG

Graphical network of the top 20 diseases related to African Tick-Bite Fever:



Diseases related to African Tick-Bite Fever

Symptoms & Phenotypes for African Tick-Bite Fever

Symptoms:

12
  • fever
  • eschar
  • maculopapular rash

MGI Mouse Phenotypes related to African Tick-Bite Fever:

44
id Description MGI Source Accession Score Top Affiliating Genes
1 hematopoietic system MP:0005397 9.55 CCL5 CD40LG IFNG IL13 SELE
2 immune system MP:0005387 9.35 IL13 SELE CCL5 CD40LG IFNG
3 integument MP:0010771 8.92 CD40LG IFNG IL13 SELE

Drugs & Therapeutics for African Tick-Bite Fever

Search Clinical Trials , NIH Clinical Center for African Tick-Bite Fever

Genetic Tests for African Tick-Bite Fever

Anatomical Context for African Tick-Bite Fever

MalaCards organs/tissues related to African Tick-Bite Fever:

39
Endothelial

Publications for African Tick-Bite Fever

Articles related to African Tick-Bite Fever:

(show top 50) (show all 52)
id Title Authors Year
1
A case of African tick-bite fever in a returning traveler. ( 27516971 )
2016
2
African tick bite fever. ( 27929573 )
2016
3
African Tick-Bite Fever in Traveler Returning to Slovenia from Uganda. ( 27648844 )
2016
4
Molecular diagnosis of African tick bite fever using eschar swabs in a traveller returning from Tanzania. ( 27488618 )
2016
5
A family with African tick bite fever. ( 25886872 )
2015
6
Images in clinical medicine: African tick-bite fever after a game-hunting expedition. ( 25738687 )
2015
7
First case of imported African tick-bite fever in Poland - Case report. ( 26403104 )
2015
8
African Tick-Bite Fever in a Returning Traveler. ( 25795527 )
2015
9
Case report of African tick-bite fever from Poland. ( 24494003 )
2013
10
Cutaneous leishmaniasis and rickettsial African tick-bite fever: a combination of exotic traveler's diseases in the same patient. ( 22788813 )
2012
11
The use of eschar swabs for the diagnosis of African tick-bite fever. ( 23141102 )
2012
12
Risk factors for African tick-bite fever in rural central Africa. ( 21460018 )
2011
13
Neurological picture. Internuclear ophthalmoplegia following African tick bite fever. ( 21421770 )
2011
14
African tick-bite fever: a new entity in the differential diagnosis of multiple eschars in travelers. Description of five cases imported from South Africa to Switzerland. ( 20233665 )
2010
15
Tache noire in African tick bite fever. ( 19861601 )
2009
16
Relative chemokine and adhesion molecule expression in Mediterranean spotted fever and African tick bite fever. ( 19091423 )
2009
17
Diagnosis of Queensland tick typhus and African tick bite fever by PCR of lesion swabs. ( 19523304 )
2009
18
Unusual location of an inoculation lesion in a traveler with African tick-bite fever returning from South Africa. ( 19930389 )
2009
19
African tick bite Fever in a Taiwanese traveler returning from South Africa: molecular and serologic studies. ( 19861602 )
2009
20
African tick bite fever--papulovesicular exanthem with fever after staying in South Africa. ( 18021248 )
2008
21
African tick bite fever in elderly patients: 8 cases in French tourists returning from South Africa. ( 18558881 )
2008
22
African tick bite fever. ( 18218581 )
2008
23
Two cases of cellulitis in the course of African tick bite fever: a fortuitous association? ( 18503259 )
2008
24
African tick bite fever in a returned traveler. ( 17939635 )
2007
25
Increased levels of soluble CD40L in African tick bite fever: possible involvement of TLRs in the pathogenic interaction between Rickettsia africae, endothelial cells, and platelets. ( 16888032 )
2006
26
Sub-acute neuropathy in patients with African tick bite fever. ( 16449002 )
2006
27
African tick bite fever: a not-so-uncommon illness in international travelers. ( 17043186 )
2006
28
Histologic features and immunodetection of African tick-bite fever eschar. ( 17073080 )
2006
29
African tick bite fever. ( 17067925 )
2006
30
Cardiac involvement in a patient with clinical and serological evidence of African tick-bite fever. ( 16242016 )
2005
31
African tick-bite fever in French travelers. ( 16422013 )
2005
32
Comparison of immunofluorescence, Western blotting, and cross-adsorption assays for diagnosis of African tick bite fever. ( 15242958 )
2004
33
African tick-bite fever. ( 15301327 )
2004
34
African tick-bite fever: four cases among Swiss travelers returning from South Africa. ( 15541225 )
2004
35
Sequential changes in hematologic and biochemical parameters in African tick bite fever. ( 12925109 )
2003
36
African tick bite fever in travelers to rural sub-Equatorial Africa. ( 12766836 )
2003
37
African tick bite fever: not a spotless rickettsiosis! ( 12582376 )
2003
38
African tick bite fever. ( 12954562 )
2003
39
Systemic inflammatory responses in African tick-bite fever. ( 12696016 )
2003
40
Outbreak of African tick-bite fever in six Italian tourists returning from South Africa. ( 11939395 )
2002
41
African tick-bite fever in South Africa. ( 12379945 )
2002
42
African tick-bite fever imported into Norway: presentation of 8 cases. ( 10447320 )
1999
43
Imported African tick bite fever: a case report. ( 10344666 )
1999
44
African tick-bite fever among international travelers--Oregon, 1998. ( 9832471 )
1998
45
African Tick-Bite Fever: A Case Report. ( 9815517 )
1997
46
African tick-bite fever. An imported spotless rickettsiosis. ( 8996049 )
1997
47
Rickettsia africae sp. nov., the etiological agent of African tick bite fever. ( 8934912 )
1996
48
African tick-bite fever: a new spotted fever group rickettsiosis under an old name. ( 1357393 )
1992
49
South African tick-bite fever complicated by severe encephalopathy. ( 1598654 )
1992
50
Correlation of the distribution of Rickettsia conorii, microscopic lesions, and clinical features in South African tick bite fever. ( 3885774 )
1985

Variations for African Tick-Bite Fever

Expression for African Tick-Bite Fever

Search GEO for disease gene expression data for African Tick-Bite Fever.

Pathways for African Tick-Bite Fever

Pathways related to African Tick-Bite Fever according to GeneCards Suite gene sharing:

(show all 22)
id Super pathways Score Top Affiliating Genes
1
Show member pathways
12.96 CCL5 CD40LG IFNG IL13
2
Show member pathways
12.5 CD40LG IFNG IL13
3
Show member pathways
12.44 CCL5 IFNG IL13
4 12.17 CCL5 CD40LG IFNG
5 11.56 CCL5 IFNG
6 11.5 IFNG IL13
7
Show member pathways
11.47 CD40LG IFNG
8 11.37 CCL5 IL13
9 11.3 IFNG SELE
10 11.25 IFNG IL13 SELE
11 11.23 CCL5 IL13
12 11.2 IFNG IL13
13 11.1 CCL5 SELE
14 11.02 IFNG SELE
15 10.98 CD40LG IFNG
16 10.94 IFNG IL13
17
Show member pathways
10.93 CD40LG IFNG SELE
18 10.88 IFNG IL13
19 10.82 IFNG IL13
20 10.74 IFNG IL13
21 10.66 CCL5 CD40LG IL13
22 10.49 CD40LG IFNG SELE

GO Terms for African Tick-Bite Fever

Cellular components related to African Tick-Bite Fever according to GeneCards Suite gene sharing:

id Name GO ID Score Top Affiliating Genes
1 external side of plasma membrane GO:0009897 9.13 CD40LG IFNG IL13
2 extracellular space GO:0005615 9.02 CCL5 CD40LG IFNG IL13 SELE

Biological processes related to African Tick-Bite Fever according to GeneCards Suite gene sharing:

(show all 12)
id Name GO ID Score Top Affiliating Genes
1 immune response GO:0006955 9.56 CCL5 CD40LG IFNG IL13
2 movement of cell or subcellular component GO:0006928 9.51 IFNG IL13
3 regulation of insulin secretion GO:0050796 9.49 CCL5 IFNG
4 neutrophil chemotaxis GO:0030593 9.48 CCL5 IFNG
5 positive regulation of smooth muscle cell proliferation GO:0048661 9.46 CCL5 IL13
6 inflammatory response GO:0006954 9.46 CCL5 CD40LG IL13 SELE
7 positive regulation of cell adhesion GO:0045785 9.43 CCL5 IFNG
8 positive regulation of tyrosine phosphorylation of STAT protein GO:0042531 9.4 CCL5 IFNG
9 response to tumor necrosis factor GO:0034612 9.37 CCL5 SELE
10 positive regulation of interleukin-12 production GO:0032735 9.32 CD40LG IFNG
11 positive regulation of T cell proliferation GO:0042102 9.13 CCL5 CD40LG IFNG
12 leukocyte cell-cell adhesion GO:0007159 8.8 CCL5 CD40LG SELE

Molecular functions related to African Tick-Bite Fever according to GeneCards Suite gene sharing:

id Name GO ID Score Top Affiliating Genes
1 cytokine activity GO:0005125 8.92 CCL5 CD40LG IFNG IL13

Sources for African Tick-Bite Fever

3 CDC
7 CNVD
9 Cosmic
10 dbSNP
11 DGIdb
16 ExPASy
18 FMA
28 GO
29 GTR
30 HGMD
31 HMDB
32 HPO
33 ICD10
34 ICD10 via Orphanet
35 ICD9CM
36 IUPHAR
37 KEGG
38 LifeMap
40 MedGen
42 MeSH
43 MESH via Orphanet
44 MGI
46 NCI
47 NCIt
48 NDF-RT
51 NINDS
52 Novoseek
54 OMIM
55 OMIM via Orphanet
59 PubMed
60 QIAGEN
65 SNOMED-CT via Orphanet
67 TGDB
68 Tocris
69 UMLS
70 UMLS via Orphanet
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