MCID: AFR002
MIFTS: 42

African Tick-Bite Fever malady

Summaries for African Tick-Bite Fever

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Disease Ontology:9 A spotted fever that has material basis in rickettsia africae, which is transmitted by ticks (amblyomma hebraeum and amblyomma variegatum). the infection has symptom fever, has symptom eschar and has symptom maculopapular rash.

MalaCards based summary: African Tick-Bite Fever, also known as rickettsia africae spotted fever, is related to cutaneous leishmaniasis and leishmaniasis, and has symptoms including fever, eschar and maculopapular rash. An important gene associated with African Tick-Bite Fever is CCL5 (chemokine (C-C motif) ligand 5), and among its related pathways are Cell adhesion Cell matrix glycoconjugates and Chemokine Superfamily: Human/Mouse Ligand-Receptor Interactions. The compounds mycophenolic acid and mcp 1 have been mentioned in the context of this disorder. Affiliated tissues include skin and endothelial, and related mouse phenotypes are respiratory system and no phenotypic analysis.

Wikipedia:63 African tick bite fever is a bacterial infection transmitted by the Amblyomma, Dermacentor or the... more...

Aliases & Classifications for African Tick-Bite Fever

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African Tick-Bite Fever, Aliases & Descriptions:

Name: African Tick-Bite Fever 9 11
Rickettsia Africae Spotted Fever 9
 
South African Tick-Bite Fever 9
African Tick Bite Fever 60


External Ids:

Disease Ontology9 DOID:0050035

Related Diseases for African Tick-Bite Fever

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Diseases related to African Tick-Bite Fever via text searches within MalaCards or GeneCards Suite gene sharing:

(show top 50)    (show all 100)
idRelated DiseaseScoreTop Affiliating Genes
1cutaneous leishmaniasis30.8IL10, IFNG
2leishmaniasis30.6IFNG, IL10, IL13
3boutonneuse fever10.5
4spotted fever10.5
5typhus10.5
6filariasis10.5IL13
7pustulosis palmaris et plantaris10.4SELE
8queensland tick typhus10.4
9internuclear ophthalmoplegia10.4
10cellulitis10.4
11exanthem10.4
12ophthalmoplegia10.4
13endotheliitis10.4
14mediterranean spotted fever10.4
15eosinophilic pneumonia10.3CCL5, IL13
16vernal keratoconjunctivitis10.3CCL5, IL13
17periapical granuloma10.3CCL3, CCL5
18encephalitis10.3CCL5, CCL3
19allergic rhinitis10.3SELE, IL13
20systemic mastocytosis10.3CCL3, CCL5
21respiratory failure10.3IL13, CCL5
22psoriatic arthritis10.2IL13, SELE
23pulmonary eosinophilia10.2CCL3, IL13
24alcoholic hepatitis10.2CCL3, CCL5
25bullous pemphigoid10.2IL13, CCL5
26dengue disease10.2CCL5, CCL3
27extrinsic allergic alveolitis10.2CCL5, CCL3
28rhinitis10.2CCL5, IL13
29interstitial lung disease10.2CCL5, CCL3
30pleural tuberculosis10.2IFNG, CCL3
31tropical spastic paraparesis10.2CCL3, IFNG
32aspergillosis10.2CCL3, IFNG
33tuberculoid leprosy10.2IFNG, IL10
34behcet's disease10.2CCL3, SELE
35lepromatous leprosy10.2IFNG, IL10
36toxic shock syndrome10.2CCL3, IFNG
37visceral leishmaniasis10.1IFNG, IL10
38acute graft versus host disease10.1IL10, IFNG
39diabetes mellitus, insulin-dependent10.1IFNG, IL10
40lupus nephritis10.1CCL5, IL10
41bronchiolitis10.1CCL3, CCL5, IL13
42pulmonary disease, chronic obstructive10.1CCL3, CCL5, IL13
43peripheral vascular disease10.1VWF, SELE
44thrombotic thrombocytopenic purpura, acquired10.1VWF, SELE
45raynaud disease10.1VWF, SELE
46hepatitis b10.1IFNG, IL10
47cutaneous t cell lymphoma10.1IFNG, SELE
48dermatitis10.1SELE, IFNG, IL13
49lymphopenia10.1IFNG, IL10
50pulmonary sarcoidosis10.1IFNG, CCL5, CCL3

Graphical network of the top 20 diseases related to African Tick-Bite Fever:



Diseases related to african tick-bite fever

Symptoms for African Tick-Bite Fever

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Symptoms:

 9
  • fever
  • eschar
  • maculopapular rash

Drugs & Therapeutics for African Tick-Bite Fever

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Drug clinical trials:

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Search NIH Clinical Center for African Tick-Bite Fever

Genetic Tests for African Tick-Bite Fever

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Anatomical Context for African Tick-Bite Fever

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MalaCards organs/tissues related to African Tick-Bite Fever:

31
Skin, Endothelial

Animal Models for African Tick-Bite Fever or affiliated genes

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MGI Mouse Phenotypes related to African Tick-Bite Fever:

35
idDescriptionMGI Source AccessionScoreTop Affiliating Genes
1MP:00053888.6IL13, IL10, IFNG, SELE
2MP:00030128.2VWF, IFNG, IL10, IL13
3MP:00053818.1VWF, CCL3, IFNG, IL10, IL13
4MP:00053847.6VWF, SELE, CCL3, IFNG, IL10, IL13
5MP:00053767.6VWF, SELE, CCL3, IFNG, IL10, IL13
6MP:00107687.5VWF, SELE, CCL3, IFNG, IL10, IL13
7MP:00053977.4IL13, VWF, SELE, CCL3, CCL5, IFNG
8MP:00053877.4VWF, SELE, CCL3, CCL5, IFNG, IL10

Publications for African Tick-Bite Fever

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Articles related to African Tick-Bite Fever:

(show all 45)
idTitleAuthorsYear
1
Images in clinical medicine: African tick-bite fever after a game-hunting expedition. (25738687)
2015
2
African Tick-Bite Fever in a Returning Traveler. (25795527)
2015
3
A family with African tick bite fever. (25886872)
2015
4
Case report of African tick-bite fever from Poland. (24494003)
2013
5
The use of eschar swabs for the diagnosis of African tick-bite fever. (23141102)
2012
6
Cutaneous leishmaniasis and rickettsial African tick-bite fever: a combination of exotic traveler's diseases in the same patient. (22788813)
2012
7
Neurological picture. Internuclear ophthalmoplegia following African tick bite fever. (21421770)
2011
8
Risk factors for African tick-bite fever in rural central Africa. (21460018)
2011
9
African tick-bite fever: a new entity in the differential diagnosis of multiple eschars in travelers. Description of five cases imported from South Africa to Switzerland. (20233665)
2010
10
Relative chemokine and adhesion molecule expression in Mediterranean spotted fever and African tick bite fever. (19091423)
2009
11
Unusual location of an inoculation lesion in a traveler with African tick-bite fever returning from South Africa. (19930389)
2009
12
Tache noire in African tick bite fever. (19861601)
2009
13
Diagnosis of Queensland tick typhus and African tick bite fever by PCR of lesion swabs. (19523304)
2009
14
African tick bite Fever in a Taiwanese traveler returning from South Africa: molecular and serologic studies. (19861602)
2009
15
African tick bite fever in elderly patients: 8 cases in French tourists returning from South Africa. (18558881)
2008
16
African tick bite fever--papulovesicular exanthem with fever after staying in South Africa. (18021248)
2008
17
African tick bite fever. (18218581)
2008
18
Two cases of cellulitis in the course of African tick bite fever: a fortuitous association? (18503259)
2008
19
African tick bite fever in a returned traveler. (17939635)
2007
20
African tick bite fever. (17067925)
2006
21
African tick bite fever: a not-so-uncommon illness in international travelers. (17043186)
2006
22
Histologic features and immunodetection of African tick-bite fever eschar. (17073080)
2006
23
Increased levels of soluble CD40L in African tick bite fever: possible involvement of TLRs in the pathogenic interaction between Rickettsia africae, endothelial cells, and platelets. (16888032)
2006
24
Cardiac involvement in a patient with clinical and serological evidence of African tick-bite fever. (16242016)
2005
25
African tick-bite fever in French travelers. (16422013)
2005
26
African tick-bite fever. (15301327)
2004
27
Comparison of immunofluorescence, Western blotting, and cross-adsorption assays for diagnosis of African tick bite fever. (15242958)
2004
28
African tick-bite fever: four cases among Swiss travelers returning from South Africa. (15541225)
2004
29
African tick bite fever in travelers to rural sub-Equatorial Africa. (12766836)
2003
30
Sequential changes in hematologic and biochemical parameters in African tick bite fever. (12925109)
2003
31
African tick bite fever: not a spotless rickettsiosis! (12582376)
2003
32
Systemic inflammatory responses in African tick-bite fever. (12696016)
2003
33
Outbreak of African tick-bite fever in six Italian tourists returning from South Africa. (11939395)
2002
34
African tick-bite fever in South Africa. (12379945)
2002
35
Imported African tick bite fever: a case report. (10344666)
1999
36
African tick-bite fever imported into Norway: presentation of 8 cases. (10447320)
1999
37
African tick-bite fever among international travelers--Oregon, 1998. (9832471)
1998
38
African tick-bite fever. An imported spotless rickettsiosis. (8996049)
1997
39
African Tick-Bite Fever: A Case Report. (9815517)
1997
40
Rickettsia africae sp. nov., the etiological agent of African tick bite fever. (8934912)
1996
41
South African tick-bite fever complicated by severe encephalopathy. (1598654)
1992
42
African tick-bite fever: a new spotted fever group rickettsiosis under an old name. (1357393)
1992
43
Correlation of the distribution of Rickettsia conorii, microscopic lesions, and clinical features in South African tick bite fever. (3885774)
1985
44
South African tick-bite fever (1931-1981). (7036374)
1981
45
A method for increasing the infectivity of yolk-sac cultures of the rickettsiae of epidemic and murine typhus, and South African tick-bite fever. (20282007)
1946

Variations for African Tick-Bite Fever

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Expression for genes affiliated with African Tick-Bite Fever

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Search GEO for disease gene expression data for African Tick-Bite Fever.

Pathways for genes affiliated with African Tick-Bite Fever

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Pathways related to African Tick-Bite Fever according to GeneCards Suite gene sharing:

(show all 24)
idSuper pathways (with members indented)ScoreTop Affiliating Genes
19.7CCL5, SELE
2
Show member pathways
9.6CCL5, CCL3
39.5IFNG, IL13
49.4IFNG, SELE
5
Show member pathways
IL27-mediated signaling events36
9.4IL10, IFNG
6
Show member pathways
9.1CCL5, IFNG, IL13
79.1IL13, IFNG, SELE
8
Show member pathways
9.0IFNG, IL10, IL13
9
Show member pathways
9.0IL13, IL10, IFNG
109.0IL13, IL10, IFNG
11
Show member pathways
Type III interferon signaling36
9.0IL13, IL10, IFNG
129.0IL13, IL10, IFNG
139.0IL13, IL10, IFNG
149.0IL10, IFNG, SELE
159.0IL10, IFNG, SELE
169.0CCL3, CCL5, IFNG
17
Show member pathways
8.9CCL3, IFNG, IL10
18
Show member pathways
8.8CCL3, CCL5, IL10, IL13
19
Show member pathways
8.8CCL3, CCL5, IL10, IL13
20
Show member pathways
8.8CCL3, CCL5, IL10, IL13
21
Show member pathways
Toll-like receptor signaling pathway36
Regulation of toll-like receptor signaling pathway36
8.5CCL3, CCL5, IFNG, IL10
22
Show member pathways
8.2CCL3, CCL5, IFNG, IL10, IL13
23
Show member pathways
8.2IL13, IL10, IFNG, CCL5, CCL3

Compounds for genes affiliated with African Tick-Bite Fever

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Compounds related to African Tick-Bite Fever according to GeneCards Suite gene sharing:

(show top 50)    (show all 141)
idCompoundScoreTop Affiliating Genes
1mycophenolic acid43 49 1211.6IL13, SELE, CCL5
2mcp 1439.5CCL3, CCL5, IL10
3mdms439.5CCL3, CCL5, IL10
4amphotericin b439.4IL13, IFNG, CCL5
5alpha-galactosylceramide439.4IL13, IFNG, IL10
6il-12439.3IL10, IFNG, IL13
7indoleamine439.3IFNG, IL13, IL10
8mip 1alpha439.2IL10, IL13, CCL3, CCL5
9polymyxin b439.2IL10, IFNG, SELE
10okt3439.1IL10, IFNG, SELE
11fluticasone propionate43 49 59 1212.1CCL5, IL13, IFNG, SELE
12glatiramer acetate43 1210.1IL10, CCL5, IL13, IFNG
13lipoteichoic acid439.1CCL3, IL10, SELE
14indinavir43 49 1211.1CCL5, CCL3, IFNG
15thalidomide43 49 59 1212.0IL13, IL10, IFNG, CCL5
16homocysteine43 2410.0VWF, SELE, CCL3, CCL5
17triptolide439.0CCL3, CCL5, IFNG
18rolipram43 59 2811.0IFNG, IL10, IL13, SELE
19pdtc438.9CCL5, CCL3, SELE, IFNG
20calcitriol43 59 24 1211.9IL10, IFNG, CCL5, IL13
21polyinosinic-polycytidylic acid438.9SELE, IL10, CCL3, IFNG
22budesonide43 49 1210.8IL13, CCL5, IFNG
23groalpha438.8IL13, SELE, CCL3, CCL5, IL10
24aspirin43 49 28 2411.7SELE, VWF, IL13, CCL5
25ly294002438.7SELE, CCL5, CCL3, IL13, IL10
26guanine43 24 1210.7IL10, SELE, VWF, CCL3
27lactate438.6CCL3, CCL5, IL13, SELE, VWF
28gm-csf43 289.6IFNG, IL10, CCL5, IL13, CCL3
29il 10438.6IL13, CCL3, IL10, IFNG, CCL5
30tarc438.6IL10, IFNG, IL13, CCL5, CCL3
31cyclophosphamide43 49 1210.6IL13, CCL3, IL10, SELE, VWF
32ccl343 289.6CCL5, CCL3, IFNG, IL10, IL13
33hydrocortisone43 2 59 1211.6CCL5, IFNG, IL10, CCL3, IL13
34heparin43 28 24 1211.6IL13, SELE, VWF, CCL3, CCL5
35ionomycin438.6CCL3, CCL5, IFNG, IL10, IL13
36tacrolimus43 49 1210.5IL13, IL10, IFNG, CCL5, CCL3
37aspartate438.5IL10, VWF, SELE, CCL3, IL13
38prednisolone43 28 1210.4VWF, CCL3, IFNG, IL10, IL13
39endotoxin438.2CCL5, CCL3, IFNG, IL10, IL13, SELE
40rantes438.2SELE, CCL5, IL13, IL10, IFNG, CCL3
41sb 20358043 599.2SELE, CCL5, IFNG, IL10, IL13, CCL3
42pge2438.1IL10, SELE, CCL3, IL13, CCL5, IFNG
43cycloheximide438.1SELE, IL10, IFNG, CCL5, CCL3, IL13
44simvastatin43 49 59 28 24 1213.0IL10, VWF, SELE, CCL3, CCL5, IFNG
45cyclosporin a43 28 5910.0CCL5, IFNG, CCL3, VWF, IL10, IL13
46dexamethasone43 49 28 1211.0IL13, IL10, IFNG, CCL5, CCL3, VWF
47histamine43 28 249.7VWF, SELE, CCL3, CCL5, IFNG, IL10
48vegf437.6IL13, CCL3, VWF, SELE, CCL5, IFNG
49nitric oxide43 24 129.6IL13, VWF, SELE, CCL3, IFNG, CCL5
50cysteine437.6VWF, CCL3, CCL5, IL13, MTCP1, IFNG

GO Terms for genes affiliated with African Tick-Bite Fever

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Cellular components related to African Tick-Bite Fever according to GeneCards Suite gene sharing:

idNameGO IDScoreTop Affiliating Genes
1external side of plasma membraneGO:00098979.0IL13, IFNG, VWF
2extracellular regionGO:00055767.8VWF, CCL3, CCL5, IFNG, IL13
3extracellular spaceGO:00056157.6IL13, IL10, IFNG, CCL5, CCL3, SELE

Biological processes related to African Tick-Bite Fever according to GeneCards Suite gene sharing:

(show all 32)
idNameGO IDScoreTop Affiliating Genes
1leukocyte cell-cell adhesionGO:000715910.0SELE, CCL5
2positive regulation of natural killer cell chemotaxisGO:0200050310.0CCL5, CCL3
3eosinophil chemotaxisGO:004824510.0CCL5, CCL3
4negative regulation by host of viral transcriptionGO:004392210.0CCL3, CCL5
5macrophage chemotaxisGO:004824610.0CCL5, CCL3
6monocyte chemotaxisGO:000254810.0CCL3, CCL5
7positive regulation of smooth muscle cell proliferationGO:004866110.0CCL5, IL13
8cellular response to interferon-gammaGO:007134610.0CCL3, CCL5
9positive regulation of calcium ion transportGO:00519289.9CCL5, CCL3
10positive chemotaxisGO:00509189.9CCL3, CCL5
11lipopolysaccharide-mediated signaling pathwayGO:00316639.9CCL5, CCL3
12protein kinase B signalingGO:00434919.9CCL5, CCL3
13cellular response to interleukin-1GO:00713479.9CCL5, CCL3
14cellular response to organic cyclic compoundGO:00714079.9CCL3, CCL5
15regulation of sensory perception of painGO:00519309.8IL10, CCL3
16positive regulation of MHC class II biosynthetic processGO:00453489.8IL10, IFNG
17calcium-mediated signalingGO:00197229.8CCL3, SELE
18negative regulation of growth of symbiont in hostGO:00441309.8IL10, IFNG
19positive regulation of cell adhesionGO:00457859.8IFNG, CCL5
20cellular response to tumor necrosis factorGO:00713569.8CCL5, CCL3
21response to toxic substanceGO:00096369.7CCL5, CCL3
22positive regulation of interleukin-1 beta secretionGO:00507189.7CCL3, IFNG
23positive regulation of T cell proliferationGO:00421029.7IFNG, CCL5
24MAPK cascadeGO:00001659.7CCL3, CCL5
25cellular calcium ion homeostasisGO:00068749.6CCL5, CCL3
26positive regulation of tumor necrosis factor productionGO:00327609.6IFNG, CCL3
27neutrophil chemotaxisGO:00305939.6CCL3, IFNG
28calcium ion transportGO:00068169.5CCL5, CCL3
29cellular response to lipopolysaccharideGO:00712229.4IL10, IFNG
30exocytosisGO:00068879.3CCL5, CCL3
31cell-cell signalingGO:00072679.2CCL3, CCL5, IL10, IL13
32inflammatory responseGO:00069548.8IL13, IL10, CCL5, CCL3, SELE

Molecular functions related to African Tick-Bite Fever according to GeneCards Suite gene sharing:

idNameGO IDScoreTop Affiliating Genes
1phospholipase activator activityGO:00160049.7CCL5, CCL3
2CCR1 chemokine receptor bindingGO:00317269.7CCL5, CCL3
3CCR5 chemokine receptor bindingGO:00317309.6CCL5, CCL3
4chemokine activityGO:00080099.6CCL5, CCL3
5chemoattractant activityGO:00420569.3CCL5, CCL3
6cytokine activityGO:00051258.9IFNG, IL10, IL13

Products for genes affiliated with African Tick-Bite Fever

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Sources for African Tick-Bite Fever

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3CDC
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22GTR
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24HMDB
25ICD10
26ICD10 via Orphanet
27ICD9CM
28IUPHAR
29KEGG
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