Agammaglobulinemia malady

Genetics Home Reference: X-linked agammaglobulinemia (XLA) is a condition that affects the immune system and occurs almost exclusively in males. People with XLA have very few B cells, which are specialized white blood cells that help protect the body against infection. B cells can mature into the cells that produce special proteins called antibodies or immunoglobulins. Antibodies attach to specific foreign particles and germs, marking them for destruction. Individuals with XLA are more susceptible to infections because their body makes very few antibodies.¹⁷

MalaCards: Agammaglobulinemia, also known as hypogammaglobulinemia, is related to bruton-type agammaglobulinemia and congenital hypogammaglobulinemia. An important gene associated with Agammaglobulinemia is BTK (Bruton agammaglobulinemia tyrosine kinase), and among its related pathways are Immune response_NFAT in immune response and B cell receptor signaling pathway. The compounds ivig and ionomycin have been mentioned in the context of this disorder. Affiliated tissues include bone marrow, monocytes and t cells, and related mouse phenotypes are renal/urinary system and digestive/alimentary.

Disease Ontology: A b cell deficiency that is caused by a reduction in all types of gamma globulins.⁶

Wikipedia: Hypogammaglobulinemia is a type of primary immune deficiency disease characterized by a reduction in all...⁴⁴ more...

Aliases & Descriptions:

agammaglobulinemia 6 7 8 32 43 hypogammaglobulinemia 6 32 43 mu heavy chain deficiency 6

malnutrition 43 ighm 6

Disease types for agammaglobulinemia family:

agammaglobulinemia 5	agammaglobulinemia 4
agammaglobulinemia 3	agammaglobulinemia 6
agammaglobulinemia 1	agammaglobulinemia 2

Diseases related to agammaglobulinemia by text searches and GeneDecks gene sharing:

(show top 50)    (show all 660)

id	Related Disease	Score	Top Affiliating Genes
1	bruton-type agammaglobulinemia	34.9	CD164, CCNG2, IBTK
2	congenital hypogammaglobulinemia	31.8	BTK, BLNK, IGLL1
3	b cell deficiency	29.7	BTK, CD79A, IGLL1, TEC
4	follicular lymphoma	29.4	BCR, CD27, CD40, IGHM, AICDA, CR2
5	central nervous system lymphoma	29.1	BCR, CD40LG, IL2, IGHM
6	cryoglobulinemia	29.0	BCR, LAG3, CD79A, CD27, CD40LG, IGHM
7	b-cell lymphomas	28.9	BTK, BCR, CD79B, CD19, CD40, IGHM
8	cold agglutinin disease	28.6	IL6, IGHM, TNF
9	gamma chain deficiency	28.1	CFP, IL2, IL2RA, IL2RG
10	isolated growth hormone deficiency	28.0	BTK, CD79A, CD40LG
11	cd40 ligand deficiency	28.0	SH2D1A, CD79A, CD40LG, AICDA
12	hodgkin's lymphoma	27.9	SH2D1A, BCR, CD40, IL2, IL2RA, IGHM
13	hemophilia	27.9	CD4, CD40LG, IL6, IGHM, TNF
14	burkitt's lymphoma	27.8	SH2D1A, BCR, CD27, CD40LG, CD40, CD38
15	hepatitis c	27.7	CD40LG, IL2, MAPK8, TNF, ABCB7
16	malt lymphoma	27.7	CD79A, CD19, CD40, IL6, IGHM, AICDA
17	t cell deficiency	27.2	BTK, CD79A, CD4, IL2, IL2RG, MAPK8
18	cd40 deficiency	26.8	CD40LG, CD40, AICDA
19	twinning	26.7	BTK, BCR, CD79A, CD40LG, IL6, GLA
20	immunoglobulin alpha deficiency	26.6	CD79A, CD40LG, TNFRSF13B
21	mantle cell lymphoma	26.6	CD40LG, CD19, CD40, IL2, MAPK8, IGHM
22	peritonitis	26.6	CD79A, CD40LG, CD40, IL2, IL2RA, IL6
23	pyoderma	26.4	BTK, CD40LG, IL6, TNF
24	t-cell leukemia	26.4	LCP2, CD4, CD40, IL2, IL2RA, MAPK8
25	neutropenia	26.3	WAS, BTK, B3GAT1, CD79A, CD40LG, CD40
26	hairy cell leukemia	26.2	CD79A, CD40, IL2, IL2RA, IL2RG, IL6
27	acute lymphoblastic leukemia	26.0	VPREB1, BTK, BLNK, BCR, CD19, CD40
28	growth hormone deficiency	25.9	SH2D1A, BTK, CD79A, CD40LG, IL6, TNF
29	non-hodgkin lymphoma	25.9	SH2D1A, BCR, CD27, CD19, CD40, CD38
30	hemophagocytic lymphohistiocytosis	25.7	SH2D1A, IL2, IL2RA, TNF, STX11
31	diffuse large b-cell lymphoma	25.5	BLNK, BCR, CD79A, CD79B, CD40LG, CD40
32	tonsillitis	25.4	CD79A, CD27, CD4, CD40LG, CD40, CD38
33	primary biliary cirrhosis	25.3	CD79A, CD27, CD4, CD40LG, IL2, IL2RA
34	diarrhea	25.2	WAS, CD79A, CD4, CD40LG, IL2, IL6
35	thrombosis	24.9	CFP, CD79A, CD40LG, CD40, IL2, IL6
36	fabry disease	24.8	BTK, IL6, GLA, TNF
37	atherosclerosis	24.3	CD79A, CD4, CD40LG, CD40, IL2, IL2RA
38	immunodeficiency	24.2	WAS, BTK, BCR, CD79A, CD4, CD40LG
39	neuropathy	24.2	CD79A, CD4, CD40LG, IL2, IL2RA, IL6
40	chronic obstructive pulmonary disease	24.1	B3GAT1, CD79A, CD27, CD4, CD40, IL6
41	common variable immunodeficiency	24.0	SH2D1A, VPREB1, BTK, CD79A, CD27, CD40LG
42	myelodysplastic syndrome	24.0	BTK, CD40LG, CD19, CD40, CD38, IL2
43	chronic myeloid leukemia	24.0	BCR, CD19, CD38, ITK, IL6, MAPK8
44	waldenstrom macroglobulinemia	24.0	BLNK, CD27, CD40LG, CD40, IL6, MAPK8
45	systemic lupus erythematosus	23.8	BCR, CFP, CD79A, CD27, CD4, CD40LG
46	diabetes mellitus	23.8	CFP, CD79A, CD4, CD40LG, CD40, CD38
47	combined immunodeficiency	23.8	CFP, CD27, CD4, CD40LG, CD40, IL2
48	hyperthyroidism	23.7	CD79A, CD4, CD40, IL2RA, IL6, TNF
49	obstructive jaundice	23.6	CD79A, IL2, IL2RA, IL6, TNF
50	photosensitive trichothiodystrophy	23.4	CD79A, CD4, IL2, IL6, TNF, ABCB7

Approved drugs:

Drug clinical trials:

MalaCards organs/tissues related to agammaglobulinemia:

²²

MGI Mouse Phenotypes related to agammaglobulinemia:

²⁵

id	Description	MGI Source Accession	Score	Top Affiliating Genes
1	renal/urinary system phenotype	MP:0005367	8.6	POU2AF1, CXCR4, TLR8, PLCG2, CR2, NT5E
2	digestive/alimentary phenotype	MP:0005381	7.9	CXCR4, AICDA, IGHM, MAPK8, CD19, CD4
3	hematopoietic system phenotype	MP:0005397	7.6	CR2, PLEK, TLR8, POU2AF1, IGHM, IGLL1
4	tumorigenesis	MP:0002006	6.8	IGHM, AICDA, TNF, TNFRSF13B, SRC, PLCG2
5	immune system phenotype	MP:0005387	6.1	SH2D1A, IL6, IGHM, IGLL1, IBTK, TXK
6	homeostasis/metabolism phenotype	MP:0005376	5.8	PTK2B, TEC, TNFRSF13B, IGHM, NT5E, CR2
7	mortality/aging	MP:0010768	4.2	TNF, AICDA, GNB1, IGHM, TNFRSF13B, SRC
8	cellular phenotype	MP:0005384	2.4	LAG3, CD79A, CD79B, CD4, CD40LG, CD19

Articles related to agammaglobulinemia:

(show top 50)    (show all 124)

id	Title	Authors	Year	Affiliating Genes
1	Agammaglobulinemia associated with BCRa8> B cells and e nhanced expression of CD19. (21693761)	Dobbs A.K.... Conley M.E.	2011	BCR, CD19
2	BTK gene mutation in two non-identical twins with X-l inked agammaglobulinemia associated with polyarticular juvenile idiopathic arth ritis. (21991724)	VA!ncsa A.... Szekanecz Z.	2011	BTK
3	Mutation of the BTK gene and clinical feature of X-li nked agammaglobulinemia in mainland China. (19039656)	Wang Y.... Miyawaki T.	2009	BTK
4	Transient myelodysplastic syndrome in X-linked agammaglobulinemia with a novel Btk mutation. (18726917)	Narula G.... Currimbhoy Z.	2008	BTK
5	Familial hemophagocytic lymphohistiocytosis in two brothers with X-linked agammaglobulinemia. (18421721)	Schultz K.A.... Kumar A.	2008	STX11
6	Mutations of the Igbeta gene cause agammaglobulinemia in man. (17709424)	Ferrari S.... Plebani A.	2007	BTK, CD79B, IGHM
7	Potential application of gene therapy to X-linked agammaglobulinemia. (17969561)	Moreau T.... Chabannon C.	2007	BTK
8	X-linked agammaglobulinemia diagnosed in adulthood: a case report. (16926138)	Mitsui T.... Nojima Y.	2006	BTK
9	De novo mutation in the BTK gene of atypical X-linked agammaglobulinemia in a patient with recurrent pyoderma. (16729790)	Lin M.T.... Yang H.C.	2006	BTK
10	Genotype/phenotype correlations in X-linked agammaglobulinemia. (16297664)	Broides A.... Conley M.E.	2006	TEC
11	BTK: 22 novel and 25 recurrent mutations in European patients with X-linked agammaglobulinemia. (14974089)	Fiorini M.... Notarangelo L.D.	2004	BTK
12	Widely divergent clinical phenotype of x-linked agammaglobulinemia in two cousins (15185441)	Jansen A.G.... Bredius R.G.	2004	BTK
13	Sustained correction of B-cell development and function in a murine model of X-linked agammaglobulinemia (XLA) using retroviral-mediated gene transfer. (15142874)	Yu P.W.... Rawlings D.J.	2004	BTK
14	Screening of the Bruton Tyrosine Kinase (BTK) Gene Mutations in 13 Iranian Patients with Presumed X-Linked Agammaglobulinemia. (17301411)	Aghamohammadi A.... Miyawaki T.	2004	BTK
15	Gene symbol: btk. Disease: Bruton agammaglobulinemia. (12974276)	Chien Y.H.	2003	BTK
16	Long-lasting memory-resting and memory-effector CD4+ T cells in human X-linked agammaglobulinemia. (11877289)	Paroli M.... Barnaba V.	2002	BTK
17	Unimpaired activation of c-Jun NH2-terminal kinase (JNK) 1 upon CD40 stimulation in B cells of patients with X-linked agammaglobulinemia. (12148599)	Brunner C.... Schuster V.	2002	BTK, MAPK8, CD40
18	Novel Igalpha (CD79a) gene mutation in a Turkish patient with B cell- deficient agammaglobulinemia. (11920841)	Wang Y.... Miyawaki T.	2002	CD79A
19	Clinical and mutational characteristics of X-linked agammaglobulinemia and its carrier identified by flow cytometric assessment combined with genetic analysis. (11742281)	Kanegane H.... Miyawaki T.	2001	BTK
20	Maternal germinal mosaicism of X-linked agammaglobulinemia. (11241495)	Sakamoto M.... Shinomiya N.	2001	BTK
21	Role of the PHTH module in protein substrate recognition by Bruton's agammaglobulinemia tyrosine kinase. (11577078)	Lowry W.E.... Huang X.Y.	2001	BTK, SRC
22	A case of X-linked agammaglobulinemia diagnosed in adulthood. (11286545)	Stewart D.M.... Nelson D.L.	2001	BTK
23	Bruton's tyrosine kinase mutations in 8 Chinese families with X-linked agammaglobulinemia. (10737994)	Yip K.L.... Lau Y.L.	2000	BTK
24	Point mutation in intron 11 of Bruton's tyrosine kina se in atypical X-linked agammaglobulinemia. (11192530)	Shinomiya N.... Miyawaki T.	2000	BTK
25	BTK mutations in patients with X-linked agammaglobulinemia: lack of correlation between presence of peripheral B lymphocytes and specific mutations. (11102984)	Tao L.... Schwaber J.	2000	BTK
26	Stability and peptide binding specificity of Btk SH2 domain: molecular basis for X-linked agammaglobulinemia. (11206059)	Tzeng S.R.... Cheng J.W.	2000	BTK, BLNK
27	Characterization of a CD38-like 78-kilodalton soluble protein released from B cell lines derived from patients with X-linked agammaglobulinemia. (9637716)	Mallone R.... Malavasi F.	1998	BTK
28	BTKbase, mutation database for X-linked agammaglobulinemia (XLA). (9399844)	Vihinen M.... Smith C.I.	1998	BTK
29	Mutations in btk in patients with presumed X-linked agammaglobulinemia. (9545398)	Conley M.E.... Rohrer J.	1998	BTK
30	Mutation screening of the BTK gene in 56 families with X-linked agammaglobulinemia (XLA): 47 unique mutations without correlation to clinical course. (9445504)	Holinski-Feder E.... Meindl A.	1998	BTK
31	A novel single basepair insertion in exon 6 of the Bruton's tyrosine kinase (Btk) gene from a Japanese X-linked agammaglobulinemia patient with growth hormone insufficiency. (9554752)	Abo K.... Sumino K.	1998	BTK
32	BTKbase, mutation database for X-linked agammaglobulinemia (XLA). (9016530)	Vihinen M.... Smith C.I.E.	1997	BTK
33	Molecular and structural characterization of five novel mutations in the Bruton's tyrosine kinase gene from patients with X-linked agammaglobulinemia. (9260159)	Saha B.K.... Vihinen M.	1997	BTK, TEC
34	BTKbase, mutation database for X-linked agammaglobulinemia (XLA). (8594569)	Vihinen M.... Smith C.I.E.	1996	BTK
35	Neutropenia in X-linked agammaglobulinemia. (8938104)	Farrar J.E.... Conley M.E.	1996	BTK
36	Structural basis for pleckstrin homology domain mutations in X-linked agammaglobulinemia. (7849006)	Vihinen M.... Smith C.I.E.	1995	BTK, PLEK
37	The spectrum of mutations in Btk that cause X-linked agammaglobulinemia. (7554467)	Conley M.E.... Rohrer J.	1995	BTK
38	Structural basis for X-linked agammaglobulinemia (XLA): mutations at interacting Btk residues R562, W563, and A582. (7554468)	Maniar H.S.... Smith C.I.	1995	BTK
39	Genomic organization of the Btk gene and exon scanning for mutations in patients with X-linked agammaglobulinemia. (7880320)	Hagemann T.L.... Kwan S.-P.	1994	BTK, SRC
40	An exon-skipping mutation in the btk gene of a patient with X-linked agammaglobulinemia and isolated growth hormone deficiency. (8013627)	Duriez B.... Goossens M.	1994	BTK
41	Mutation analysis of the Bruton's tyrosine kinase gene in X-linked agammaglobulinemia: identification of a mutation which affects the same codon as is altered in immunodeficient xid mice. (8162018)	de Weers M.... Hendriks R.W.	1994	BTK
42	Genomic organization of mouse and human Bruton's agammaglobulinemia tyrosine kinase (Btk) loci. (7989760)	Sideras P.... Larsson I.	1994	BTK, ITK, PTK2B
43	The genomic structure of human BTK, the defective gene in X-linked agammaglobulinemia. (7927535)	Rohrer J.... Conley M.E.	1994	BTK
44	Brief report: a point mutation in the SH2 domain of B ruton's tyrosine kinase in atypical X-linked agammaglobulinemia. (8164701)	Saffran D.C.... Conley M.E.	1994	BTK
45	Genomic organization and structure of Bruton agammaglobulinemia tyrosine kinase: localization of mutations associated with varied clinical presentations and course in X chromosome-linked agammaglobulinemia. (8090769)	Ohta Y.... Litman G.W.	1994	BTK, TEC
46	X-linked agammaglobulinemia--gene cloning and future prospects. (8274198)	Kinnon C.... Lovering R.C.	1993	BTK
47	Bone marrow cells in X-linked agammaglobulinemia expr ess pre-B-specific genes (lambda-like and V pre-B) and present immunoglobulin V -D-J gene usage strongly biased to a fetal-like repertoire. (8473505)	Milili M.... Schiff C.	1993	IGHM
48	X-Linked Agammaglobulinemia (20301626)	Conley M.E.... Howard V.C.	1993	BTK
49	Carrier detection in agammaglobulinemia by X chromosome inactivation analysis. (1354911)	Miyashita T.... Kobayashi N.	1992	PGK1
50	Diversity of immunoglobulin heavy chain gene segment rearrangement in B lymphoblastoid cell lines from X-linked agammaglobulinemia patients. (1915549)	Timmers E.... Schuurman R.K.	1991	BTK, IGHM

Genes related to agammaglobulinemia according to GeneCards:

(show top 50)    (show all 58)

id	Symbol	Description	Score	GeneCards Section Context
1	BTK	Bruton agammaglobulinemia tyrosine kinase	11.1	Transcripts, Summaries, Orthologs, Aliases & Descriptions (show all 5 sections) Publications
2	IBTK	inhibitor of Bruton agammaglobulinemia tyrosine kinase	11.1	Publications, Orthologs, Aliases & Descriptions, Transcripts
3	IGLL1	immunoglobulin lambda-like polypeptide 1	11.1	Summaries, Publications
4	LRRC8A	leucine rich repeat containing 8 family, member A	11.1	Publications, Summaries
5	AGMX2	agammaglobulinemia, X-linked 2 (with growth hormone deficiency)	11.1	Aliases & Descriptions
6	HNRNPH2	heterogeneous nuclear ribonucleoprotein H2 (H')	11.0	Summaries, Publications
7	IGHM	immunoglobulin heavy constant mu	11.0	Publications
8	TEC	tec protein tyrosine kinase	11.0	Publications
9	SRC	v-src sarcoma (Schmidt-Ruppin A-2) viral oncogene homolog (avian)	11.0	Publications
10	CD79B	CD79b molecule, immunoglobulin-associated beta	11.0	Publications
11	BMX	BMX non-receptor tyrosine kinase	11.0	Publications
12	CFP	complement factor properdin	11.0
13	BLNK	B-cell linker	11.0	Publications
14	SH3BP5	SH3-domain binding protein 5 (BTK-associated)	11.0	Publications
15	PLEK	pleckstrin	11.0	Publications
16	ITK	IL2-inducible T-cell kinase	11.0	Publications
17	WAS	Wiskott-Aldrich syndrome	11.0
18	CD40	CD40 molecule, TNF receptor superfamily member 5	11.0	Publications
19	PLCG2	phospholipase C, gamma 2 (phosphatidylinositol-specific)	11.0
20	CD79A	CD79a molecule, immunoglobulin-associated alpha	11.0	Publications
21	CD40LG	CD40 ligand	11.0	Publications
22	BCR	breakpoint cluster region	11.0	Publications
23	VPREB1	pre-B lymphocyte 1	11.0	Publications
24	SPRYD3	SPRY domain containing 3	11.0	Disorders
25	LAG3	lymphocyte-activation gene 3	11.0	Publications
26	TIMM8A	translocase of inner mitochondrial membrane 8 homolog A (yeast)	11.0	Publications
27	CCNG2	cyclin G2	11.0
28	DUSP5	dual specificity phosphatase 5	11.0	Publications
29	POU2AF1	POU class 2 associating factor 1	11.0	Publications
30	STX11	syntaxin 11	11.0	Publications
31	PRKACG	protein kinase, cAMP-dependent, catalytic, gamma	11.0	Publications
32	TLR8	toll-like receptor 8	11.0	Publications
33	CD164	CD164 molecule, sialomucin	11.0
34	CD19	CD19 molecule	11.0	Publications
35	TXK	TXK tyrosine kinase	11.0	Publications
36	PGK1	phosphoglycerate kinase 1	11.0	Publications
37	IL2RG	interleukin 2 receptor, gamma	11.0
38	AICDA	activation-induced cytidine deaminase	11.0
39	GNB1	guanine nucleotide binding protein (G protein), beta polypeptide 1	11.0	Publications
40	SH2D1A	SH2 domain containing 1A	11.0
41	GLA	galactosidase, alpha	11.0	Publications
42	TNFRSF13B	tumor necrosis factor receptor superfamily, member 13B	11.0
43	NT5E	5'-nucleotidase, ecto (CD73)	11.0
44	CD27	CD27 molecule	11.0
45	ABCB7	ATP-binding cassette, sub-family B (MDR/TAP), member 7	11.0	Publications
46	B3GAT1	beta-1,3-glucuronyltransferase 1 (glucuronosyltransferase P)	11.0
47	GNG2	guanine nucleotide binding protein (G protein), gamma 2	11.0	Publications
48	CR2	complement component (3d/Epstein Barr virus) receptor 2	11.0
49	LCP2	lymphocyte cytosolic protein 2 (SH2 domain containing leukocyte protein of 76kDa)	11.0
50	CD38	CD38 molecule	11.0

Pathways related to agammaglobulinemia according to GeneDecks:

(show top 50)    (show all 125)

id	Pathway	Score	Top Affiliating Genes
1	Immune response_NFAT in immune response41	10.5	ITK, LCP2
2	B cell receptor signaling pathway20	10.1	CD19, BLNK, PLCG2, CD79B, BTK, CR2
3	Primary immunodeficiency20	10.0	BTK, BLNK, CD4, IL2RG, IGLL1
4	Immune response NFAT in immune response10	10.0	PLCG2, ITK, CD79B, CD79A, LCP2, BLNK
5	G-protein signaling G-Protein beta/gamma signaling cascades10	10.0	PRKACG, PLCG2, GNB1, BTK, SRC, GNG2
6	G-protein signaling_G-Protein beta/gamma signaling cascades41	10.0	GNB1, GNG2, BTK, SRC, PRKACG, PLCG2
7	Immune response BCR pathway10	10.0	IGHM, BTK, CR2, BLNK, CD79B, CD19
8	Immune response_BCR pathway41	10.0	CD79B, CD79A, PLCG2, BTK, IGHM, CD19
9	Fc-Gamma-RIIB Signaling in B-Cells36	10.0	CD79B, MAPK8, BLNK, PLCG2, BTK, CD79A
10	Immune System38	9.8	PTK2B, TEC, IGHM, IL2RG, CD79B, CD79A
11	G-Beta Gamma Signaling36	9.7	GNB1, BTK, SRC, GNG2, PLCG2, PRKACG
12	G-protein signaling_G-Protein alpha-12 signaling pathway41	9.6	BTK, PRKACG, GNB1, GNG2, PLCG2, MAPK8
13	G-protein signaling G-Protein alpha-12 signaling pathway10	9.6	PRKACG, PLCG2, GNG2, GNB1, MAPK8, BTK
14	G-protein signaling G-Protein alpha-q signaling cascades10	9.6	GNG2, GNB1, BTK, PLCG2
15	PI3K Signaling in B-Lymphocyte36	9.5	CR2, MAPK8, TEC, BTK, CD79B, CD79A
16	G-protein signaling_G-Protein alpha-q signaling cascades41	9.4	GNG2, PLCG2, GNB1, BTK, PTK2B
17	G-protein signaling Regulation of p38 and JNK signaling mediated by G-proteins10	9.4	PTK2B, GNG2, BLNK, BTK, SRC, MAPK8
18	G-protein signaling_Regulation of p38 and JNK signaling mediated by G-proteins41	9.4	BTK, BLNK, MAPK8, GNB1, GNG2, PTK2B
19	Chemotaxis CXCR4 signaling pathway10	9.4	PTK2B, SRC, GNG2, GNB1, CXCR4
20	Chemotaxis_CXCR4 signaling pathway41	9.3	GNB1, GNG2, PTK2B, CXCR4, SRC
21	IL-15 Signaling and its Primary Biological Effects in Different Immune Cell Types37	9.2	IL2RA, IL2, IL2RG
22	Chemokine signaling pathway20	9.2	ITK, GNB1, GNG2, PTK2B, PRKACG, CXCR4
23	Osteoclast differentiation20	9.2	TEC, BTK, MAPK8, LCP2, PLCG2, BLNK
24	Tyrosine Kinases / Adaptors3	9.1	TEC, SRC, PTK2B, IL2RA, ITK, LCP2
25	CD28 Signaling in T-Helper Cell36	9.1	MAPK8, PLCG2, TEC, TXK, ITK, CD4
26	NFAT Signaling and Lymphocyte Interactions36	8.9	CD4, IL2, IL2RG, BTK
27	Transendothelial Migration of Leukocytes36	8.9	GNG2, ITK, BMX, BTK, WAS, GNB1
28	CCR5 Pathway in Macrophages36	8.9	CD4, GNB1, GNG2, PTK2B, MAPK8, PLCG2
29	Colorectal Cancer Metastasis36	8.8	IL6, GNB1, TLR8, GNG2, SRC, TNF
30	IL-2 Signaling and its Primary Biological Effects in Different Immune Cell Types37	8.8	TNF, IL2, IL2RA, IL2RG
31	Intestinal immune network for IgA production20	8.5	CD40LG, CD40, IL2, IL6, AICDA, TNFRSF13B
32	T cell receptor signaling pathway20	8.4	CD40LG, TNF, LCP2, CD4, ITK, IL2
33	ICos-ICosL Pathway in T-Helper Cell36	8.3	CD4, LCP2, ITK, IL2RA, IL2RG, TEC
34	Lymphocyte Signaling3	8.1	BMX, ITK, IL2RA, AICDA, TEC, PTK2B
35	IP3 Pathway36	8.1	IL2, LCP2, IL6, CD19, CD79A, ITK
36	Immune response IL-22 signaling pathway10	8.1	MAPK8, IL2RA, IL2, CD4, IL2RG
37	Hematopoietic cell lineage20	8.0	CD38, CD19, IL6, TNF, CR2, CD4
38	Phospholipase-C Pathway36	7.7	BTK, CD79A, IL6, GNB1, GNG2, SRC
39	p70S6K Signaling36	7.7	CD19, IL6, PLCG2, IL2, IL2RA, MAPK8
40	JNK Pathway36	7.5	MAPK8, IL6, CD4, IL2RA, IL2, GNB1
41	Cytokine-cytokine receptor interaction20	7.3	IL6, TNFRSF13B, TNF, IL2RG, IL2RA, IL2
42	Molecular Mechanisms of Cancer36	7.3	BTK, TNFRSF13B, GNG2, MAPK8, IL6, IL2RG
43	NFAT in Immune Response36	7.2	CD79B, CD79A, LCP2, BLNK, BTK, CD4
44	MAPK Signaling36	6.9	PRKACG, PLCG2, SRC, GNB1, PTK2B, TNF
45	MAPK Family Pathway36	6.8	TNF, GNG2, GNB1, MAPK8, IL2RA, IL2
46	STAT3 Pathway36	6.7	IL2RA, CXCR4, IL2RG, SRC, TNFRSF13B, TNF
47	p38 Signaling36	6.6	CXCR4, CD4, IL2, IL2RA, IL2RG, BTK
48	Antioxidant Action of Vitamin-C36	6.5	CD4, PRKACG, IL2RG, IL6, IL2RA, MAPK8
49	Akt Signaling36	6.3	TNF, GNG2, CD4, TNFRSF13B, PTK2B, CXCR4
50	Tec Kinases Signaling36	4.9	IL2, BMX, IL2RA, ITK, CD4, WAS

Compounds related to agammaglobulinemia according to GeneDecks:

(show top 50)    (show all 105)

id	Compound	Score	Top Affiliating Genes
1	ivig32	10.7	AICDA, BTK
2	ionomycin32	10.2	WAS, PTK2B, CD40, BTK
3	inositol32	10.0	SH2D1A, BCR, TEC, PLEK, PLCG2, SRC
4	pge232	10.0	CD4, PTK2B
5	sandoglobulin32	9.9	CD79A, CD40LG, IL6
6	estrogen32	9.8	PTK2B, BMX, NT5E, CCNG2
7	blys32	9.8	BCR, CD79A, CD40, CD40LG, TNF, TNFRSF13B
8	bcma32	9.7	TNFRSF13B, CD40, TNF, CD27
9	ganglioside32	9.5	BCR, CD4, GLA, CD38, CD40
10	vegf32	9.4	PGK1, BMX, CD40LG, CD40, PTK2B, SRC
11	piceatannol32 42 9 9	12.3	SRC, PLCG2, BTK, MAPK8, TNF, PTK2B
12	threonine32	9.3	CD4, LCP2, ITK, GLA, BTK, PLEK
13	mycophenolate mofetil32 9 9	11.3	CD40, CD79A, CD40LG, IL2, IL2RA
14	pkcs32	9.1	PLEK, PTK2B, MAPK8, CD4, PRKACG
15	proline32	9.1	PLEK, SRC, PTK2B, TEC, CD4, LCP2
16	wortmannin32 42	10.1	PLCG2, MAPK8, PLEK, TEC, PTK2B, SRC
17	rapamycin32 42	10.0	MAPK8, WAS, IL2, PTK2B, CCNG2, SRC
18	phosphotyrosine32	8.9	ITK, SH2D1A, CD4, BTK, BCR, LCP2
19	ly29400232	8.9	SRC, PLEK, PLCG2, TNF, MAPK8, IL6
20	aspirin32 34 18	10.9	CD79A, SRC, PTK2B, IL2RA, CD40LG, CXCR4
21	heparin32 9 18 9	11.8	CD79A, CFP, B3GAT1, CXCR4, CD4, SRC
22	phosphoinositide32	8.7	PLEK, BCR, LCP2, CD79B, MAPK8, TEC
23	sb 20358032 42	9.6	SRC, CXCR4, PTK2B, TNF, IL6, BTK
24	glutamate32	8.5	PTK2B, CD38, CD4, CD79A, GLA, CD40
25	triptolide32	8.3	CD40, IL2, IL6, MAPK8, TNF
26	fibrinogen32	8.3	BTK, LCP2, CD40LG, CD40, IL6, CD79A
27	tacrolimus32 34 9 9	11.2	SRC, CD79A, CD40, IL2, IL2RA, PTK2B
28	cyclosporin a32 42	9.2	IL2RG, CD40, ITK, IL2, IL2RA, TEC
29	il 1032	8.2	CD40, TNF, IL2, IL2RA, IL6
30	adp32 18	9.2	BCR, MAPK8, ITK, CD38, CD40, CD40LG
31	h2o232	8.1	CD40, LCP2, BCR, PGK1, IL2RA, CD79A
32	chloroquine32 34 9 9	11.0	IL2, CD4, CD79A, IL2RA, TNF, PTK2B
33	n acetylcysteine32	8.0	PLCG2, CD79A, CD40LG, TNF, SRC, PTK2B
34	okt332	8.0	CD40LG, IL2, IL2RA, IL6, TNF, CR2
35	cysteine32	8.0	CD38, CD40, SRC, PLEK, BTK, CD40LG
36	rituximab32 34 9 9	10.8	CD40, CD40LG, BCR, CD79A, CD38, IL2
37	indomethacin32 9 9	9.6	CD40, TNF, PTK2B, SRC, IL2RA, PLCG2
38	neopterin32	7.4	CD38, IL2RA, IL2, TNF, CD40, CD40LG
39	rantes32	7.2	TNF, CD4, CXCR4, IL6, IL2RA, IL2
40	histamine32 18	8.1	BTK, B3GAT1, CD79A, CD40LG, CD40, IL2
41	actinomycin d32	7.0	CD40, CD38, IL2, CD40LG, TNF, IL6
42	lipid32	7.0	CD4, GLA, IL6, CD38, CD40, CD19
43	genistein32 9 18 9	9.7	CD40LG, SRC, PTK2B, BTK, BCR, PLEK
44	herbimycin a32 42	7.6	SRC, CXCR4, CD4, CD40LG, CD40, IL2
45	dexamethasone32 42 34 9 9	10.5	IL2, IL6, IL2RA, SRC, PTK2B, MAPK8
46	phosphatidylinositol32	6.3	WAS, BTK, BMX, LCP2, CD79B, CD4
47	cycloheximide32	6.1	AICDA, MAPK8, IL6, CD40, TNF, CD4
48	calcium32 9 18 9	8.8	CD38, CD40, IBTK, GLA, TXK, TNFRSF13B
49	serine32	5.7	CD40LG, MAPK8, DUSP5, TNF, IL2, CD40
50	tyrosine32	3.8	DUSP5, CD79B, LCP2, BCR, BLNK, BMX

Cellular components related to agammaglobulinemia according to GeneDecks:

id	Name	GO ID	Score	Top Affiliating Genes
1	external side of plasma membrane	GO:009897	7.2	LAG3, CXCR4, CR2, TNFRSF13B, TNF, IL2RG
2	plasma membrane	GO:005886	5.9	IGHM, GNB1, GNG2, TXK, TNF, TEC

Biological processes related to agammaglobulinemia according to GeneDecks:

(show all 19)

id	Name	GO ID	Score	Top Affiliating Genes
1	B cell proliferation	GO:042100	10.4	CD79A, CD40LG, CD40
2	adaptive immune response	GO:002250	10.2	TXK, ITK, BTK
3	B cell differentiation	GO:030183	10.2	PLCG2, AICDA, CD40LG, CD79A, BLNK
4	interleukin-4 production	GO:032633	10.1	TXK, ITK
5	regulation of immunoglobulin secretion	GO:051023	10.0	TNF, CD40, CD40LG
6	B cell receptor signaling pathway	GO:050853	9.9	BTK, PLCG2, TEC, CD38, CD19, CD79B
7	NK T cell differentiation	GO:001865	9.9	TXK, ITK
8	cytokine production	GO:001816	9.7	CD4, ITK, TXK
9	calcium-mediated signaling	GO:019722	9.6	CXCR4, PLCG2, TNF, BTK
10	T cell receptor signaling pathway	GO:050852	9.5	PLCG2, TXK, ITK, CD4, LCP2, WAS
11	positive regulation of B cell proliferation	GO:030890	9.3	IL2, CD38, CD40, CD40LG
12	blood coagulation	GO:007596	9.2	PRKACG, PLEK, PLCG2, SRC, GNG2, GNB1
13	humoral immune response	GO:006959	9.2	POU2AF1, TNF, IL6, BLNK, SH2D1A
14	positive regulation of interferon-gamma production	GO:032729	9.1	TNF, TXK, IL2, CD40LG
15	platelet activation	GO:030168	9.0	PLEK, PLCG2, SRC, GNG2, GNB1, IL6
16	cell surface receptor signaling pathway	GO:007166	8.8	PTK2B, TNFRSF13B, IL2RA, CD19, CD4, CD27
17	inflammatory response	GO:006954	8.6	CXCR4, TLR8, TNF, IL6, CD40, CD40LG
18	signal transduction	GO:007165	8.4	PRKACG, SRC, PTK2B, GNB1, IL2RG, ITK
19	immune response	GO:006955	7.7	CR2, IGLL1, IGHM, IL2RG, IL2RA, IL2

Molecular functions related to agammaglobulinemia according to GeneDecks:

id	Name	GO ID	Score	Top Affiliating Genes
1	non-membrane spanning protein tyrosine kinase activity	GO:004715	9.6	BTK, SRC, PTK2B, TEC, TXK, ITK
2	protein tyrosine kinase activity	GO:004713	9.5	SRC, PTK2B, BCR, BMX, BTK
3	signal transducer activity	GO:004871	9.4	BMX, CD40, GNB1, GNG2, PTK2B, PLCG2
4	transmembrane signaling receptor activity	GO:004888	9.1	CR2, CD4, CD79B, CD27, CD79A, LAG3