MCID: AGR013
MIFTS: 9

Age-Related Hearing Impairment 1

Aliases & Classifications for Age-Related Hearing Impairment 1

MalaCards integrated aliases for Age-Related Hearing Impairment 1:

Name: Age-Related Hearing Impairment 1 54 13 69

External Ids:

OMIM 54 612448

Summaries for Age-Related Hearing Impairment 1

OMIM : 54
Age-related hearing impairment (ARHI), or presbycusis, is the progressive bilaterally symmetric deterioration of hearing ability that occurs with aging. Studies of the cochlea in many animal species and of the histopathology of human temporal bones have shown that stria vascularis volumes and spiral ganglion cell, inner hair cell, and outer hair cell populations, as well as many other cochlear cell types and structures, undergo age-related degeneration. Environmental risk factors for ARHI include noise exposure, smoking, ototoxic medication, and cardiovascular disease. Heritability estimates vary between 0.25 and 0.75 depending on, among other factors, study design (family vs twins), age range of the study population, and the phenotype studied (Huyghe et al., 2008). (612448)

MalaCards based summary : Age-Related Hearing Impairment 1 An important gene associated with Age-Related Hearing Impairment 1 is ARHI1 (Age-Related Hearing Impairment 1). The drugs Estradiol and Estradiol valerate have been mentioned in the context of this disorder. Affiliated tissues include bone.

Related Diseases for Age-Related Hearing Impairment 1

Diseases in the Age-Related Hearing Impairment 2 family:

Age-Related Hearing Impairment 1

Symptoms & Phenotypes for Age-Related Hearing Impairment 1

Clinical features from OMIM:

612448

Drugs & Therapeutics for Age-Related Hearing Impairment 1

Drugs for Age-Related Hearing Impairment 1 (from DrugBank, HMDB, Dgidb, PharmGKB, IUPHAR, NovoSeek, BitterDB):

(show all 9)
id Name Status Phase Clinical Trials Cas Number PubChem Id
1
Estradiol Approved, Investigational, Vet_approved Phase 1 50-28-2 5757
2 Estradiol valerate Phase 1 979-32-8
3 Hormone Antagonists Phase 1
4 Hormones Phase 1
5 Hormones, Hormone Substitutes, and Hormone Antagonists Phase 1
6 Estradiol 17 beta-cypionate Phase 1
7 Estradiol 3-benzoate Phase 1
8 Pharmaceutical Solutions Phase 1
9 Polyestradiol phosphate Phase 1

Interventional clinical trials:


id Name Status NCT ID Phase Drugs
1 Efficacy and Safety of AUT00063 Versus Placebo in Age-Related Hearing Loss Completed NCT02345031 Phase 2 AUT00063;Placebo
2 A Study Of The Effects Of PF-04958242 In Subjects With Age-Related Hearing Loss Completed NCT01518920 Phase 1 PF-04958242;PF-04958242;Placebo
3 Neural Changes in the Aging Auditory System Completed NCT00264407 Phase 1 Hormone Replacement Therapy - HRT
4 The Baltimore HEARS Pilot Study Completed NCT02045511
5 Genetic Study of Age Related Hearing Loss Completed NCT01732289 Early Phase 1
6 Assessment of Age-related Hearing Loss in HIV-1 Patients Recruiting NCT02154971

Search NIH Clinical Center for Age-Related Hearing Impairment 1

Genetic Tests for Age-Related Hearing Impairment 1

Anatomical Context for Age-Related Hearing Impairment 1

MalaCards organs/tissues related to Age-Related Hearing Impairment 1:

39
Bone

Publications for Age-Related Hearing Impairment 1

Variations for Age-Related Hearing Impairment 1

Expression for Age-Related Hearing Impairment 1

Search GEO for disease gene expression data for Age-Related Hearing Impairment 1.

Pathways for Age-Related Hearing Impairment 1

GO Terms for Age-Related Hearing Impairment 1

Sources for Age-Related Hearing Impairment 1

3 CDC
7 CNVD
9 Cosmic
10 dbSNP
11 DGIdb
16 ExPASy
18 FMA
28 GO
29 GTR
30 HGMD
31 HMDB
32 HPO
33 ICD10
34 ICD10 via Orphanet
35 ICD9CM
36 IUPHAR
37 KEGG
38 LifeMap
40 MedGen
42 MeSH
43 MESH via Orphanet
44 MGI
46 NCI
47 NCIt
48 NDF-RT
51 NINDS
52 Novoseek
54 OMIM
55 OMIM via Orphanet
59 PubMed
60 QIAGEN
65 SNOMED-CT via HPO
66 SNOMED-CT via Orphanet
67 TGDB
68 Tocris
69 UMLS
70 UMLS via Orphanet
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