MCID: AGR014
MIFTS: 9

Age-Related Hearing Impairment 2

Aliases & Classifications for Age-Related Hearing Impairment 2

MalaCards integrated aliases for Age-Related Hearing Impairment 2:

Name: Age-Related Hearing Impairment 2 53 13
Presbycusis 2 53 69
Arhi2 53

External Ids:

OMIM 53 612976
MedGen 39 C2751814
UMLS 69 C2751814

Summaries for Age-Related Hearing Impairment 2

OMIM : 53 Age-related hearing impairment (ARHI), or presbycusis, is the progressive, bilaterally symmetric deterioration of hearing ability that occurs with aging. Studies of the cochlea in many animal species and of the histopathology of human temporal bones have shown that stria vascularis volumes and spiral ganglion cell, inner hair cell, and outer hair cell populations, as well as many other cochlear cell types and structures, undergo age-related degeneration. Environmental risk factors for ARHI include noise exposure, smoking, ototoxic medication, and cardiovascular disease. Heritability estimates vary between 0.25 and 0.75 depending on, among other factors, study design (family vs twins), age range of the study population, and the phenotype studied (Huyghe et al., 2008). (612976)

MalaCards based summary : Age-Related Hearing Impairment 2, also known as presbycusis 2, is related to age-related hearing loss. An important gene associated with Age-Related Hearing Impairment 2 is ARHI2 (Age-Related Hearing Impairment 2). Affiliated tissues include bone.

Related Diseases for Age-Related Hearing Impairment 2

Diseases in the Age-Related Hearing Impairment 2 family:

Age-Related Hearing Impairment 1

Diseases related to Age-Related Hearing Impairment 2 via text searches within MalaCards or GeneCards Suite gene sharing:

# Related Disease Score Top Affiliating Genes
1 age-related hearing loss 10.9

Symptoms & Phenotypes for Age-Related Hearing Impairment 2

Clinical features from OMIM:

612976

Drugs & Therapeutics for Age-Related Hearing Impairment 2

Search Clinical Trials , NIH Clinical Center for Age-Related Hearing Impairment 2

Genetic Tests for Age-Related Hearing Impairment 2

Anatomical Context for Age-Related Hearing Impairment 2

MalaCards organs/tissues related to Age-Related Hearing Impairment 2:

38
Bone

Publications for Age-Related Hearing Impairment 2

Variations for Age-Related Hearing Impairment 2

Expression for Age-Related Hearing Impairment 2

Search GEO for disease gene expression data for Age-Related Hearing Impairment 2.

Pathways for Age-Related Hearing Impairment 2

GO Terms for Age-Related Hearing Impairment 2

Sources for Age-Related Hearing Impairment 2

3 CDC
7 CNVD
9 Cosmic
10 dbSNP
11 DGIdb
16 ExPASy
18 FMA
27 GO
28 GTR
29 HGMD
30 HMDB
31 HPO
32 ICD10
33 ICD10 via Orphanet
34 ICD9CM
35 IUPHAR
36 KEGG
37 LifeMap
39 MedGen
41 MeSH
42 MESH via Orphanet
43 MGI
45 NCI
46 NCIt
47 NDF-RT
50 NINDS
51 Novoseek
53 OMIM
54 OMIM via Orphanet
58 PubMed
60 QIAGEN
65 SNOMED-CT via HPO
66 SNOMED-CT via Orphanet
67 TGDB
68 Tocris
69 UMLS
70 UMLS via Orphanet
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