MCID: AGR014
MIFTS: 11

Age-Related Hearing Impairment 2

Aliases & Classifications for Age-Related Hearing Impairment 2

MalaCards integrated aliases for Age-Related Hearing Impairment 2:

Name: Age-Related Hearing Impairment 2 54 13
Presbycusis 2 69

External Ids:

OMIM 54 612976

Summaries for Age-Related Hearing Impairment 2

OMIM : 54
Age-related hearing impairment (ARHI), or presbycusis, is the progressive, bilaterally symmetric deterioration of hearing ability that occurs with aging. Studies of the cochlea in many animal species and of the histopathology of human temporal bones have shown that stria vascularis volumes and spiral ganglion cell, inner hair cell, and outer hair cell populations, as well as many other cochlear cell types and structures, undergo age-related degeneration. Environmental risk factors for ARHI include noise exposure, smoking, ototoxic medication, and cardiovascular disease. Heritability estimates vary between 0.25 and 0.75 depending on, among other factors, study design (family vs twins), age range of the study population, and the phenotype studied (Huyghe et al., 2008). (612976)

MalaCards based summary : Age-Related Hearing Impairment 2, is also known as presbycusis 2. An important gene associated with Age-Related Hearing Impairment 2 is ARHI2 (Age-Related Hearing Impairment 2). The drugs Pharmaceutical Solutions and Folic Acid have been mentioned in the context of this disorder. Affiliated tissues include bone.

Related Diseases for Age-Related Hearing Impairment 2

Symptoms & Phenotypes for Age-Related Hearing Impairment 2

Clinical features from OMIM:

612976

Drugs & Therapeutics for Age-Related Hearing Impairment 2

Drugs for Age-Related Hearing Impairment 2 (from DrugBank, HMDB, Dgidb, PharmGKB, IUPHAR, NovoSeek, BitterDB):

(show all 17)
id Name Status Phase Clinical Trials Cas Number PubChem Id
1 Pharmaceutical Solutions Phase 1
2
Folic Acid Approved, Nutraceutical, Vet_approved 59-30-3 6037
3
leucovorin Approved, Nutraceutical 58-05-9 143 6006
4
Huperzine A Investigational 102518-79-6
5 Hematinics
6 Hemostatics
7 Micronutrients
8 Trace Elements
9 Vitamin B Complex
10 Vitamins
11 Cholinergic Agents
12 Cholinesterase Inhibitors
13 Neuroprotective Agents
14 Neurotransmitter Agents
15 Protective Agents
16 Folate Nutraceutical
17 Vitamin B9 Nutraceutical

Interventional clinical trials:


id Name Status NCT ID Phase Drugs
1 Efficacy and Safety of AUT00063 Versus Placebo in Age-Related Hearing Loss Completed NCT02345031 Phase 2 AUT00063;Placebo
2 A Study Of The Effects Of PF-04958242 In Subjects With Age-Related Hearing Loss Completed NCT01518920 Phase 1 PF-04958242;PF-04958242;Placebo
3 Workshops for Veterans With Vision and Hearing Loss Completed NCT01109576 Early Phase 1
4 The Effect of Sound Stimulation on Pure-tone Hearing Threshold Completed NCT01184248
5 The Effect of Sound Stimulation on Hearing Ability Completed NCT01434446
6 The Effect of Folic Acid on Atherosclerosis, Cognitive Performance and Hearing Completed NCT00110604
7 The RBANS-H in Older Adults With Normal Hearing or Age-related Hearing Loss Recruiting NCT03208608
8 Effects of Hearing Rehabilitative Interventions and Huperzine A on Presbycusis(Δ,kHz, dB,MMSE, AD) Recruiting NCT03101722 Huperzine A

Search NIH Clinical Center for Age-Related Hearing Impairment 2

Genetic Tests for Age-Related Hearing Impairment 2

Anatomical Context for Age-Related Hearing Impairment 2

MalaCards organs/tissues related to Age-Related Hearing Impairment 2:

39
Bone

Publications for Age-Related Hearing Impairment 2

Variations for Age-Related Hearing Impairment 2

Expression for Age-Related Hearing Impairment 2

Search GEO for disease gene expression data for Age-Related Hearing Impairment 2.

Pathways for Age-Related Hearing Impairment 2

GO Terms for Age-Related Hearing Impairment 2

Sources for Age-Related Hearing Impairment 2

3 CDC
7 CNVD
9 Cosmic
10 dbSNP
11 DGIdb
16 ExPASy
18 FMA
28 GO
29 GTR
30 HGMD
31 HMDB
32 HPO
33 ICD10
34 ICD10 via Orphanet
35 ICD9CM
36 IUPHAR
37 KEGG
38 LifeMap
40 MedGen
42 MeSH
43 MESH via Orphanet
44 MGI
46 NCI
47 NCIt
48 NDF-RT
51 NINDS
52 Novoseek
54 OMIM
55 OMIM via Orphanet
59 PubMed
60 QIAGEN
65 SNOMED-CT via HPO
66 SNOMED-CT via Orphanet
67 TGDB
68 Tocris
69 UMLS
70 UMLS via Orphanet
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