Age Related Macular Degeneration malady

Genetics Home Reference: Age-related macular degeneration is an eye disease that is a leading cause of vision loss in older people in developed countries. The vision loss usually becomes noticeable in a person's sixties or seventies and tends to worsen over time.¹⁷

MalaCards: Age Related Macular Degeneration, also known as age-related macular degeneration, is related to retinal degeneration and kuhnt-junius degeneration. An important gene associated with Age Related Macular Degeneration is HMCN1 (hemicentin 1), and among its related pathways are Lectin Induced Complement Pathway and Complement Pathway. The drugs interferon alfa-2a,recombinant and interferon alfa-2a and the compounds glucose and cyclophosphamide have been mentioned in the context of this disorder. Affiliated tissues include bone marrow, retina and skin, and related mouse phenotypes are pigmentation and respiratory system.

OMIM: 603075

Aliases & Descriptions:

age related macular degeneration 6 8 43 age-related macular degeneration 6 16 17 macular degeneration, age-related 17 33 senile macular degeneration 6 16 armd 16 17

senile macular retinal degeneration 6 macular degeneration, senile 32 macular degeneration 17 amd 17

Diseases related to age related macular degeneration by text searches and GeneDecks gene sharing:

(show top 50)    (show all 1008)

id	Related Disease	Score	Top Affiliating Genes
1	retinal degeneration	35.4	RDH8, SERPINF1, CLU, BEST1, GUCA1A, FGF2
2	kuhnt-junius degeneration	35.0	VEGFA, RAP2A, CFH, CFHR2, CFHR4, CFHR5
3	macular degeneration	34.6	LRP6, RFX5, SGCD, KIR3DL1, VTN, RDH8
4	maculopathy	34.3	SELE, SERPINF1, BEST1, CKB, CFB, CFH
5	macular dystrophy	34.1	BEST1, GUCA1A, IMPG1, FADS1, ABCA4, ELOVL4
6	age-related maculopathy	33.8	CFH, APOB, APOE, ABCA4, TIMP3
7	atherosclerosis	33.7	SELE, CETP, MMP3, ELN, TLR4
8	choroiditis	33.3	VTN, SELE, SERPINF1, SERPINE1, SERPING1, VLDLR
9	retinal drusen	32.9	CFB, CFH, ARMS2, IMPG1, C2, EFEMP1
10	multifocal choroiditis	32.6	CFB, CFH, ARMS2, HTRA1
11	hepatitis	32.3	GSR, F2, HLA-DRB1, CYP1A2, CYP2E1, CR1
12	alzheimer's disease	31.9	APOE, APP, A2M, ACE, HFE
13	retinal disease	31.7	SERPINF1, SERPINE1, VEGFA, CLUL1, BEST1, KDR
14	diabetic macular edema	30.4	SERPINF1, VEGFA, MGST1, FGF2, IL6, CCL2
15	spina bifida	30.1	NAT2, MTRR, MTHFR, MTR, XRCC1, APOB
16	iron overload	30.1	GSTM1, IMMT, APOB, F5, F2, CAT
17	malaria	29.7	CD36, IL10, IL1A, CR1, NOS2, C6
18	immunodeficiency	29.4	KIR3DL1, PARP1, CD55, ITGB2, IL10, IL18
19	amyloidosis	29.0	VTN, SERPINA3, CLU, MME, MMP3, MMP9
20	colorectal cancer	28.9	NAT2, MTHFR, MTR, GSTM1, GSTP1, GSTT1
21	sleeping sickness	28.8	GSR, IL10, IL6, AMD1, NOS2, GFAP
22	retinitis	28.2	VTN, RDH8, SELE, SERPINF1, SERPINE1, BSG
23	cataract	28.1	SERPINF1, NAT2, VEGFA, BEST1, PARP1, MTHFR
24	twinning	27.9	SERPINE1, VEGFA, VEGFC, LIPC, KDR, CKB
25	non-hodgkin lymphoma	27.7	NAT2, MTR, CD59, CD55, CD46, ITGAM
26	familial adenomatous polyposis	27.4	SERPINE1, NAT2, CLU, MMP14, MMP7, GSTM1
27	non-small cell lung carcinoma	26.8	VEGFA, VEGFC, PARP1, KDR, MMP7, FLT1
28	arthritis	26.2	MMP3, IL1A, IL1B, IL6, IL8
29	glaucoma	26.2	SELE, SERPINF1, SERPINE1, VEGFA, BMP4, CLU
30	vasculitis	26.2	SELE, SERPINA3, SERPING1, VEGFA, VEGFC, KDR
31	lung carcinoma	26.0	SERPINF1, SERPINA3, BSG, NAT2, VEGFA, VEGFC
32	conjunctivitis	25.4	VEGFA, CD36, CD46, MMP9, GSR, FGA
33	glomerulonephritis	25.3	VTN, SERPINE1, SERPING1, VEGFA, CLU, PARP1
34	pneumonia	25.2	VTN, BTAF1, SELE, SERPINE1, BSG, VEGFA
35	trypanosomiasis	25.1	SELE, SERPINE1, GSR, IL10, IL18, IL1A
36	leishmaniasis	25.1	ITGAM, ITGB2, MMP9, GSR, IL10, IL1A
37	ataxia	25.0	SERPINE1, VLDLR, PARP1, SCARB1, XRCC1, MMP2
38	breast cancer	24.6	NAT2, VEGFA, KDR, MTHFR, XRCC1, MMP2
39	homocysteine	24.5	SELE, SERPINE1, SERPINA3, NAT2, VEGFA, CLU
40	inflammatory bowel disease	24.3	SELE, SERPINA3, NAT2, CD59, CD55, ITGB2
41	colon adenocarcinoma	23.9	VTN, BSG, VEGFA, BMP4, CLU, PARP1
42	neuropathy	23.9	SELE, SERPINF1, SERPINE1, SERPING1, VEGFA, PARP1
43	bladder carcinoma	23.7	SELE, BSG, VEGFA, VEGFC, CLU, KDR
44	chagas disease	23.1	SERPINE1, GSR, IL10, IL1A, IL1B, IL6
45	renal carcinoma	23.1	VEGFA, KDR, MMP9, MKI67, GSTM1, GSTP1
46	polyposis	22.3	SELE, SERPINE1, NAT2, VEGFA, CLU, MMP14
47	gingivitis	21.9	SELE, SERPINF1, SERPINE1, SERPINA3, BSG, VEGFA
48	hodgkin's lymphoma	21.2	KIR3DL1, SELE, SERPING1, BSG, NAT2, VEGFA
49	retinoblastoma	21.1	SERPINF1, BSG, VEGFA, VEGFC, BMP4, CLU
50	hypoxia	21.0	VTN, SELE, SERPINF1, SERPINE1, VLDLR, BSG

Clinical features from OMIM: 603075

Approved drugs:

Drug clinical trials:

Inferred drug relations via UMLS/NDF-RT:

^43 28 interferon, interferon alfa 2-b, interferon alfa-2a, interferon alfa-2a,recombinant, interferon alfa-2b,recombinant, interferon alfa-3n,human leukocyte derived, interferon alfacon-1, interferon beta-1a,recombinant, interferon beta-1b,recombinant, interferon gamma-1b, peginterferon alfa-2a, peginterferon alfa-2b

Cell-based therapeutics:

Genetic tests related to age related macular degeneration:

id	Genetic test	Affiliating Genes
1	Age Related Macular Degeneration clinical/research	RAX2, MT-ND2, CFB, CFH, ARMS2, FHL1, FBLN5, HTRA1, HMCN1, ERCC6 (show all 13) C2, ABCA4, C3

MalaCards organs/tissues related to age related macular degeneration:

²²

id	Organ / Tissue -> Anatomical Compartment -> Cell	Relevance
1	Eye -> Retinal Pigmented Epithelium -> Mature Retinal Pigmented Epithelium Cells	Potential therapeutic candidate, affected by disease
2	Eye -> Retinal Pigmented Epithelium -> Retinal Pigmented Epithelium Progenitor Cells	Potential therapeutic candidate, affected by disease

MGI Mouse Phenotypes related to age related macular degeneration:

²⁵ (show all 26)

id	Description	MGI Source Accession	Score	Top Affiliating Genes
1	pigmentation phenotype	MP:0001186	11.2	RDH8, SERPINF1, VLDLR, BEST1, ITGB2, MFRP
2	respiratory system phenotype	MP:0005388	11.1	LRP6, FGG, FBLN5, APOE, CCR2, CC2D1A
3	hematopoietic system phenotype	MP:0005397	10.9	RFX5, BMP4, FGF2, FGG, CCR2, CCL11
4	renal/urinary system phenotype	MP:0005367	10.3	LRP6, BMP4, CLU, CFB, CFH, CFI
5	endocrine/exocrine gland phenotype	MP:0005379	10.2	CYP1A2, PLEKHA1, TLR3, PSEN1, PSEN2
6	other phenotype	MP:0005395	10.2	SGCD, CLU, KDR, MME, MMP14, APOE
7	limbs/digits/tail phenotype	MP:0005371	9.8	LRP6, VEGFA, BMP4, MTHFR, MMP14, MMP9
8	liver/biliary system phenotype	MP:0005370	9.8	LRP6, RFX5, VEGFA, BMP4, CD36, FGA
9	embryogenesis phenotype	MP:0005380	9.8	LRP6, BTAF1, PARP1, SCARB1, XRCC1, ITGA5
10	reproductive system phenotype	MP:0005389	9.1	LRP6, SERPINF1, VEGFA, LIPC, SCARB1, CD59
11	integument phenotype	MP:0010771	9.1	LRP6, PARP1, ITGB2, MME, GSTP1, FGA
12	normal phenotype	MP:0002873	9.0	LRP6, VTN, SELE, SERPING1, VEGFA, BMP4
13	nervous system phenotype	MP:0003631	9.0	LRP6, RDH8, BTAF1, SERPINF1, VLDLR, VEGFB
14	immune system phenotype	MP:0005387	8.9	RFX5, BSG, CLU, KDR, SCARB1, MT-ND2
15	digestive/alimentary phenotype	MP:0005381	8.3	LRP6, SERPINF1, VEGFA, BMP4, CD36, MMP14
16	adipose tissue phenotype	MP:0005375	8.0	LRP6, SERPINE1, VLDLR, CD36, IL18, IL6
17	skeleton phenotype	MP:0005390	7.9	LRP6, VEGFA, BMP4, KDR, MTHFR, CFB
18	vision/eye phenotype	MP:0005391	7.8	LRP6, RDH8, SELE, SERPINF1, SEBOX, VLDLR
19	mortality/aging	MP:0010768	7.0	LRP6, SGCD, SELE, SERPINE1, VLDLR, BSG
20	tumorigenesis	MP:0002006	6.9	SERPINE1, XRCC1, FRK, MMP2, MMP7, MMP9
21	behavior/neurological phenotype	MP:0005386	6.8	LRP6, SELE, VLDLR, VEGFB, BMP4, KDR
22	growth/size phenotype	MP:0005378	6.7	LRP6, BTAF1, SELE, SERPINE1, VLDLR, BSG
23	muscle phenotype	MP:0005369	5.8	SGCD, BTAF1, VEGFA, BMP4, CLU, KDR
24	homeostasis/metabolism phenotype	MP:0005376	5.5	LRP6, SGCD, VTN, BTAF1, SELE, SERPINE1
25	cellular phenotype	MP:0005384	5.0	LRP6, SELE, VLDLR, VEGFA, BMP4, PARP1
26	cardiovascular system phenotype	MP:0005385	4.9	RFX5, SGCD, RDH8, BTAF1, SELE, SERPINF1

Articles related to age related macular degeneration:

(show top 50)    (show all 428)

id	Title	Authors	Year	Affiliating Genes
1	ARMS2/HTRA1 locus can confer differential susceptibil ity to the advanced subtypes of age-related macular degeneration. (21122828)	Sobrin L.... Seddon J.M.	2011	HTRA1, ARMS2
2	VEGF gene polymorphism and response to intravitreal b evacizumab and triple therapy in age-related macular degeneration. (21744122)	Nakata I.... Yoshimura N.	2011	VEGFA
3	Incorporating prior knowledge to facilitate discoveri es in a genome-wide association study on age-related macular degeneration. (20181037)	Lin W.Y.... Lee W.C.	2010	CFH, SGCD, CFHR4
4	Complement Factor H and High-Temperature Requirement A-1 Genotypes and Treatment Response of Age-related Macular Degeneration. (20678803)	Tsuchihashi T.... Yoneya S.	2010	VEGFA, CFH, SERPINF1
5	The involvement of complement factor B and complement component C2 in an Indian cohort with age-related macular degeneration. (19696172)	Kaur I.... Chakrabarti S.	2010	C2, CFB
6	Impaired Intracellular Signaling May Allow Up-Regulat ion of CTGF-Synthesis and Secondary Peri-Retinal Fibrosis in Human Retinal Pigm ent Epithelial Cells from Patients with Age-Related Macular Degeneration. (20238043)	Kothary P.C.... Del Monte M.A.	2010	IGF1, MAPK10, CTGF
7	The noncoding variant in complement factor H gene inc reases risk of exudative age-related macular degeneration in a Chinese populati on. (19850835)	Cui L.... Liu N.	2009	CFH, C3
8	Plasma complement components and activation fragments : associations with age-related macular degeneration genotypes and phenotypes. (19661236)	Reynolds R.... Seddon J.M.	2009	C3, C2, CFB
9	Genetic analysis of complement factor H related 5, CFHR5, in patients with age-related macular degeneration. (19365580)	Narendra U.... Hagstrom S.A.	2009	CFHR5
10	Variants in the 10q26 gene cluster (LOC387715 and HTRA1) exhibit enhanced risk of age-related macular degeneration along with CFH in Indian patients. (18436811)	Kaur I.... Chakrabarti S.	2008	CFH, HTRA1, ARMS2
11	Treatment of age-related macular degeneration: focus on ranibizumab. (19668384)	Spitzer M.S.... Szurman P.	2008	VEGFA
12	Genetic variants in three genes and smoking show strong associations with susceptibility to exudative age-related macular degeneration in a Chinese population. (19187590)	Chu J.... Dong F.T.	2008	CFH, CFB, HTRA1
13	Chlamydia pneumoniae infection, complement factor H variants, and age-related macular degeneration. (18996904)	Shen D.... Chan C.C.	2008	CFH
14	Vascular endothelial growth factor gene polymorphisms in age-related macular degeneration. (18378209)	Lin J.M.... Tsai F.J.	2008	VEGFA, CFH
15	Functional and structural implications of the complement factor H Y402H polymorphism associated with age-related macular degeneration. (18263814)	Ormsby R.J.... Gordon D.L.	2008	CFH
16	Deletion of CFHR3 and CFHR1 genes in age-related macular degeneration. (18084039)	Spencer K.L.... Haines J.L.	2008	CFH, CFHR1, CFHR3
17	Systemic complement activation in age-related macular degeneration. (18596911)	Scholl H.P.... Oppermann M.	2008	CFH, C3
18	Coagulation gene predictors of photodynamic therapy for occult choroidal neovascularization in age-related macular degeneration. (18378576)	Parmeggiani F.... Incorvaia C.	2008	F2, MTR, F13A1
19	Polymorphisms in the vascular endothelial growth factor gene and risk of age-related macular degeneration: the Rotterdam Study. (18708255)	Boekhoorn S.S.... Vingerling J.R.	2008	VEGFA
20	Association of HTRA1 polymorphism and bilaterality in advanced age-related macular degeneration. (18206206)	Chen H.... Zhang K.	2008	HTRA1
21	An update on the genetics of age-related macular degeneration. (17327825)	Scholl H.P.... Weber B.H.	2007	CFH
22	Vascular endothelial growth factor and basic fibroblast growth factor in exudative age-related macular degeneration and diffuse diabetic macular edema. (17505145)	Jonas J.B.... Neumaier M.	2007	FGF2, VEGFA
23	Human HtrA1 in the archived eyes with age-related macular degeneration. (18427598)	Chan C.C.... Tuo J.	2007	HTRA1, GTF3A
24	Haplotypes spanning the complement factor H gene are protective against age-related macular degeneration. (17724217)	Spencer K.L.... Haines J.L.	2007	CFH
25	Case-control genetic association study of fibulin-6 (FBLN6 or HMCN1) variants in age-related macular degeneration (AMD). (17216616)	Fisher S.A.... Weber B.H.	2007	HMCN1
26	Pegaptanib 1-year systemic safety results from a safety-pharmacokinetic trial in patients with neovascular age-related macular degeneration. (17509689)	.... Adamis A.P.	2007	VEGFA
27	HTRA1 variant confers similar risks to geographic atrophy and neovascular age-related macular degeneration. (17426452)	Cameron D.J.... Zhang K.	2007	CFH, HTRA1, HTR1A
28	Fibulin-5 distribution in human eyes: relevance to age-related macular degeneration. (17109857)	Mullins R.F.... Stone E.M.	2007	FBLN5
29	Analysis of the RDS/peripherin gene in age-related macular degeneration. (17362467)	Baird P.N.... Guymer R.	2007	PRPH2
30	A variant of mitochondrial protein LOC387715/ARMS2, not HTRA1, is strongly associated with age-related macular degeneration. (17884985)	Kanda A.... Swaroop A.	2007	HTRA1, PLEKHA1, ARMS2
31	Secreted proteome profiling in human RPE cell cultures derived from donors with age related macular degeneration and age matched healthy donors. (17022631)	An E.... Hathout Y.	2006	LGALS3BP
32	Serum paraoxonase 1 activity and lipid peroxidation levels in patients with age-related macular degeneration. (16374043)	Baskol G.... Ustdal M.	2006	PON1
33	Pigment epithelium-derived factor (PEDF) and vascular endothelial growth factor (VEGF) in aged human choroid and eyes with age-related macular degeneration. (16019000)	Bhutto I.A.... Lutty G.A.	2006	SERPINF1
34	Mutation screen of the cone-specific gene, CLUL1, in 376 patients with age-related macular degeneration. (17148042)	Sturgill G.M.... Hagstrom S.A.	2006	CLU, CLUL1
35	Complement factor H polymorphism in age-related macular degeneration. (15761122)	Klein R.J.... Hoh J.	2005	CFH
36	Y402H complement factor H polymorphism associated with exudative age-related macular degeneration in the French population. (16379025)	Souied E.H.... Fremeaux-Bacchi V.	2005	CFH
37	Met72Thr polymorphism of pigment epithelium-derived factor gene and susceptibility to age-related macular degeneration. (15823717)	Yamagishi S.... Takeuchi M.	2005	SERPINF1
38	Association of the M55L and Q192R paraoxonase gene polymorphisms with age-related macular degeneration. (15488805)	Baird P.N.... Guymer R.	2004	PON1
39	Cholesterol and age-related macular degeneration: is there a link? (15059717)	van Leeuwen R.... de Jong P.T.	2004	APOE
40	Nitric oxide and lipid peroxidation are increased and associated with decreased antioxidant enzyme activities in patients with age-related macular degeneration. (12678277)	Evereklioglu C.... Ozerol E.	2003	SOD1, CAT
41	Aberrant accumulation of EFEMP1 underlies drusen formation in Malattia Leventinese and age-related macular degeneration. (12242346)	Marmorstein L.Y.... Marmorstein A.D.	2002	EFEMP1
42	Analysis of the Arg345Trp disease-associated allele of the EFEMP1 gene in individuals with early onset drusen or familial age-related macular degeneration. (12427233)	Guymer R.H.... Baird P.N.	2002	EFEMP1
43	Age-related macular degeneration is associated with increased vascular endothelial growth factor, hemorheology and endothelial dysfunction. (11297487)	Lip P.L.... Lip G.Y.	2001	VEGFA
44	Lack of association of mutations of the bestrophin gene with age-related macular degeneration in non-familial Japanese patients. (11271465)	Akimoto A.... Yoshimura N.	2001	BEST1
45	Cosegregation and functional analysis of mutant ABCR (ABCA4) alleles in families that manifest both Stargardt disease and age-related macular degeneration. (11726554)	Shroyer N.F.... Lupski J.R.	2001	ABCA4
46	Novel mechanism for age-related macular degeneration: an equilibrium shift between the angiogenesis factors VEGF and PEDF. (11748590)	Ohno-Matsui K.... Mochizuki M.	2001	SERPINF1
47	Molecular genetic analysis of ABCR gene in Japanese dry form age-related macular degeneration. (10913642)	Fuse N.... Tamai M.	2000	ABCA4
48	Age-related macular degeneration in grandparents of patients with Stargardt disease: genetic study. (10458172)	Souied E.H.... Kaplan J.	1999	ABCA4
49	Mutation of the Stargardt disease gene (ABCR) in age-related macular degeneration. (9295268)	Allikmets R.... Leppert M.	1997	ABCA4
50	Distribution of growth factors in subfoveal neovascular membranes in age-related macular degeneration and presumed ocular histoplasmosis syndrome. (7661200)	Reddy V.M.... Kaplan H.J.	1995	EGF

Genes related to age related macular degeneration according to GeneCards:

(show top 50)    (show all 228)

id	Symbol	Description	Score	GeneCards Section Context
1	HMCN1	hemicentin 1	11.1	Summaries, Aliases & Descriptions, Publications
2	ARMS2	age-related maculopathy susceptibility 2	11.1	Publications, Summaries
3	CFB	complement factor B	11.1	Summaries, UniProt Related, Publications
4	HTRA1	HtrA serine peptidase 1	11.1	Summaries, Publications
5	C2	complement component 2	11.1	Publications, UniProt Related, Summaries
6	RAX2	retina and anterior neural fold homeobox 2	11.1	Summaries
7	CFHR3	complement factor H-related 3	11.1	Summaries, Publications
8	TNMD	tenomodulin	11.1	Publications, Summaries
9	PLEKHA1	pleckstrin homology domain containing, family A (phosphoinositide binding specific) member 1	11.1	Summaries, Publications
10	FBLN5	fibulin 5	11.1	Summaries, Publications
11	OPTC	opticin	11.0	Summaries
12	CFH	complement factor H	11.0	Publications
13	C1QTNF5	C1q and tumor necrosis factor related protein 5	11.0	Publications
14	GPR75	G protein-coupled receptor 75	11.0	Publications
15	CFHR1	complement factor H-related 1	11.0	Publications
16	SEBOX	SEBOX homeobox	11.0
17	MFRP	membrane frizzled-related protein	11.0	Publications
18	SERPING1	serpin peptidase inhibitor, clade G (C1 inhibitor), member 1	11.0	Publications
19	SERPINF1	serpin peptidase inhibitor, clade F (alpha-2 antiplasmin, pigment epithelium derived factor), member 1	11.0	Publications
20	C3	complement component 3	11.0	Publications
21	CFHR2	complement factor H-related 2	11.0	Publications
22	CFHR5	complement factor H-related 5	11.0	Publications
23	CX3CR1	chemokine (C-X3-C motif) receptor 1	11.0	Publications
24	NRL	neural retina leucine zipper	11.0	Publications
25	RDH8	retinol dehydrogenase 8 (all-trans)	11.0	Publications
26	CFHR4	complement factor H-related 4	11.0	Publications
27	LOXL1	lysyl oxidase-like 1	11.0	Publications
28	ERP29	endoplasmic reticulum protein 29	11.0	Publications
29	ELOVL4	ELOVL fatty acid elongase 4	11.0	Publications
30	SKIV2L	superkiller viralicidic activity 2-like (S. cerevisiae)	11.0	Publications
31	TIMP3	TIMP metallopeptidase inhibitor 3	11.0	Publications
32	BFAR	bifunctional apoptosis regulator	11.0	Publications
33	CFP	complement factor properdin	11.0	Publications
34	PROK1	prokineticin 1	11.0	Publications
35	CRYBB2	crystallin, beta B2	11.0	Publications
36	CRYBB1	crystallin, beta B1	11.0	Publications
37	ABCA4	ATP-binding cassette, sub-family A (ABC1), member 4	11.0	Publications
38	C1QTNF1	C1q and tumor necrosis factor related protein 1	11.0	Publications
39	BEST1	bestrophin 1	11.0	Publications
40	CC2D1A	coiled-coil and C2 domain containing 1A	11.0	Publications
41	RPE	ribulose-5-phosphate-3-epimerase	11.0
42	COL10A1	collagen, type X, alpha 1	11.0	Publications
43	F13B	coagulation factor XIII, B polypeptide	11.0	Publications
44	LGALS3BP	lectin, galactoside-binding, soluble, 3 binding protein	11.0	Publications
45	EFEMP1	EGF containing fibulin-like extracellular matrix protein 1	11.0	Publications
46	THY1	Thy-1 cell surface antigen	11.0	Publications
47	ERCC6	excision repair cross-complementing rodent repair deficiency, complementation group 6	11.0	Publications
48	PEA15	phosphoprotein enriched in astrocytes 15	11.0
49	CLUL1	clusterin-like 1 (retinal)	11.0	Publications
50	RLBP1	retinaldehyde binding protein 1	11.0	Publications

Pathways related to age related macular degeneration according to GeneDecks:

(show top 50)    (show all 143)

id	Pathway	Score	Top Affiliating Genes
1	Lectin Induced Complement Pathway36	11.3	C5, C7, C8A, C6, C9, MASP1
2	Complement Pathway36	11.2	MASP2, C8A, C3, C7, C9, C6
3	Complement cascade38	11.2	CFD, CFI, CD46, MASP2, MASP1, CR1
4	Immune response Lectin Induced complement pathway10	11.1	CLU, SERPING1, MASP2, MASP1, CR1, CR2
5	Immune response Alternative complement pathway10	11.1	CLU, CFB, CFD, CFH, CFI, CFP
6	Immune response_Alternative complement pathway41	11.1	C5AR1, C3, C8A, C8B, C5, C7
7	Immune response_Lectin induced complement pathway41	11.1	CR1, C8B, C8A, C5AR1, C5, SERPING1
8	Immune response Classic complement pathway10	11.0	C8B, C8A, C3, C5AR1, C5, C7
9	Immune response_Classical complement pathway41	11.0	C8B, C8A, ITGAM, C4BPB, C6, C9
10	Classical Complement Pathway36	11.0	C8A, C3, C5, C7, C9, C6
11	Staphylococcus aureus infection20	11.0	HLA-DQB1, CFB, CFD, MASP1, MASP2, IL10
12	Alternative Complement Pathway36	10.9	C8A, C3, C5, C7, C9, C6
13	Glioma Invasiveness36	10.9	ITGAM, ITGA5, VEGFB, VTN, BMP4, VEGFC
14	Complement and coagulation cascades20	10.7	C8B, C8A, C3, C5AR1, C5, C7
15	Extrinsic Prothrombin Activation Pathway36	10.4	F13A1, FGB, FGA, FGG, F5, F3
16	Metalloproteases in connective tissue degradation10	10.0	CST3, ELN, FGG, FGB, FGA, MMP9
17	Transendothelial Migration of Leukocytes36	9.9	CCL11, CCL2, CCL26, IL8, IMPG2, IMPG1
18	UPA-UPAR Pathway36	9.7	IMPG2, MAPK10, MAPK1, COL10A1, COL8A1, COL18A1
19	Akt Signaling36	9.7	IGF1R, CCL2, VEGFB, CCL11, CCL26, IL6
20	Prion diseases20	9.3	IL1A, IL1B, IL6, MAPK1, C6, C9
21	Regulation of eIF4 and p70S6K36	9.1	VEGFC, BMP4, ITGA5, ITGAM, ITGB2, IL18
22	Rheumatoid arthritis20	9.1	HLA-DRB1, IL18, IL1A, IL1B, IL6, IL8
23	Cell adhesion ECM remodeling10	9.0	IGF1R, IGF1, PLAT, TIMP3, MMP2, MMP14
24	Cell adhesion_ECM remodeling41	9.0	PLAT, VTN, SERPINE1, ITGA5, MMP14, MMP3
25	PTEN Pathway36	9.0	FGF2, PROK1, EFEMP1, BMP4, TIMP3, KDR
26	Leishmaniasis20	8.6	C3, CR1, IL1B, MAPK1, HLA-DQB1, NOS2
27	Malaria20	8.5	CR1, IL1B, IL6, IL8, CCL2, IL18
28	Pertussis20	8.5	MAPK1, SERPING1, MAPK10, IL8, IL6, IL1B
29	ILK Signaling36	8.4	CTGF, IGF1, IGF1R, MAPK1, MAPK10, IMPG2
30	Molecular Mechanisms of Cancer36	8.4	IGF1R, EFEMP1, CX3CR1, PSEN2, PSEN1, CYCS
31	NF-KappaB (p50-p65) Pathway36	8.3	IL6, TLR3, TIMP3, TLR7, EGF, KDR
32	NF-KappaB Family Pathway36	8.1	KDR, EGF, CTGF, IGF1, IL1B, IL1A
33	PPAR Pathway36	8.1	ITGB2, ITGAM, ITGA5, BMP4, VEGFB, FGF2
34	Rho Family GTPases36	8.1	VEGFB, BMP4, IL1B, IL8, MAPK10, MAPK1
35	Phospholipase-C Pathway36	8.0	ITGB2, PROK1, FGF2, IMPG1, IMPG2, FLT1
36	PAK Pathway36	8.0	VEGFB, VEGFC, BMP4, CCL2, FLT1, FGF2
37	DHA Signaling36	8.0	EGF, TIMP3, PROK1, FGF2, CTGF, FLT1
38	Tuberculosis20	8.0	TLR4, IL1B, IL1A, IL18, ITGB2, ITGAM
39	MIF Regulation of Innate Immune Cells36	7.9	IL18, TLR4, CCL24, CCL11, IL8, CCL2
40	Cytokine-cytokine receptor interaction20	7.9	CCR2, EGF, CCL24, VEGFB, CCR3, CCL11
41	ERK Signaling36	7.9	PROK1, EGF, COL18A1, COL8A1, COL10A1, CTGF
42	Pathways in cancer20	7.6	VEGFC, VEGFB, VEGFA, EGF, MMP2, MMP9
43	SOCS Pathway36	7.5	CCL11, IL6, IL8, CCL26, CCL2, IL1B
44	Tec Kinases Signaling36	7.4	CX3CR1, PROK1, TIMP3, TLR7, TLR4, TLR3
45	MAPK Signaling36	7.4	VEGFB, MAPK10, IL6, IL1B, IL1A, IMPG2
46	p38 Signaling36	7.3	CCR2, CCL26, IL8, IL6, IL1B, IL1A
47	TGF-Beta Pathway36	7.0	CCL11, KDR, CCL26, CCL2, CCL24, IGF1
48	MAPK Family Pathway36	6.9	KDR, EGF, CTGF, IGF1, BMP4, VEGFC
49	Antioxidant Action of Vitamin-C36	6.6	CCL11, CCL2, CCR2, CCR3, CCL24, IGF1R
50	JAK-STAT Pathway36	6.4	CXCR4, KDR, FLT1, FGF2, IL10, IL18

Compounds related to age related macular degeneration according to GeneDecks:

(show top 50)    (show all 520)

id	Compound	Score	Top Affiliating Genes
1	glucose32	11.1	SERPINF1, VEGFC, CKB, CFB, CFD, MME
2	cyclophosphamide32 34 9 9	13.8	ITGB2
3	malondialdehyde32	10.3	GSR, GSTM1, GSTT1, FGA, GPX1, GPX3
4	h2o232	10.3	CLU, ITGAM, ITGB2, MME, MGST1, IL18
5	carbohydrates32	10.3	SELE, BSG, SCARB1, CFI, CETP, MMP14
6	vitamin a32 9 18 9	13.0	RDH8, SERPINA3, NAT2, LIPC, SCARB1, CETP
7	egcg32	10.0	IL1A, APP, MAPK10, CAT, CYCS, KRT18
8	homocysteine32 18	10.9	SELE, SERPINE1, NAT2, MTRR, MTR, CETP
9	dmso32	9.7	CD36, ITGAM, MMP3, MMP7, APOB, F3
10	fibrinogen32	9.7	VTN, SELE, SERPINE1, SERPINA3, LIPC, CLU
11	pioglitazone32 9 9	11.6	BSG, VEGFA, LIPC, CFD, MMP2, MMP7
12	iron32 18	10.5	SERPINA3, BMP4, MT-ND2, CD59, CD55, MMP3
13	arginine32	9.4	VTN, SERPINA3, LIPC, XRCC1, CETP, ITGB2
14	histamine32 18	10.3	SELE, CD55, ITGAM, ITGB2, MME, FGA
15	n acetylcysteine32	9.3	SELE, CLU, KDR, ITGAM, MMP2, MMP3
16	calcium32 9 18 9	12.2	VTN, SERPINF1, SERPINA3, VEGFC, BMP4, LIPC
17	aspartate32	9.2	VTN, CKB, CETP, CD55, ITGB2, MMP2
18	rapamycin32 42	10.2	VEGFA, BMP4, KDR, CD46, FLT1, MAPK10
19	epinephrine32 9 18 9	12.1	VTN, SELE, ITGAM, MMP2, MMP9, GSR
20	tocopherol32	9.1	SCARB1, GSR, GSTP1, APOB, CAT, HP
21	heparin32 9 18 9	12.1	VTN, SERPINF1, SERPINE1, SERPINA3, VLDLR, BSG
22	fenofibrate32 9 9	11.0	SELE, SERPINE1, LIPC, SCARB1, CETP, MMP9
23	ascorbic acid32 18	9.9	BMP4, XRCC1, CFP, CD36, ITGAM, MME
24	thyroxine32 18	9.9	SERPINA3, LIPC, CFI, CETP, GSR, FGF2
25	anaphylatoxin32	8.8	CFP, CD59, CD55, IL1B, IL6, IL8
26	diphenyleneiodonium32	8.5	SERPINF1, VEGFA, IL1B, IL8, MAPK10, MAPK1
27	lipid32	8.4	KIR3DL1, VTN, SELE, SERPINE1, SERPINA3, VLDLR
28	8-isoprostane32	8.3	SELE, SERPINE1, MMP2, MMP9, IL10, IL6
29	doxorubicin32 34 9 9	11.3	SELE, CLU, PARP1, KDR, MMP7, MKI67
30	glutamate32	8.1	VTN, SERPINF1, BSG, CLU, KDR, MTRR
31	cysteine32	8.0	LRP6, VTN, SERPINF1, SERPINA3, NAT2, BMP4
32	4-hydroxynonenal32 18	8.9	PARP1, MME, GSR, GSTM1, GSTP1, IL10
33	methotrexate32 34 42 9 9	11.9	SELE, SERPINE1, SERPINA3, NAT2, MTRR, MTHFR
34	alanine32	7.8	VTN, SELE, SERPING1, SCARB1, MT-ND2, CFH
35	tgf beta132	7.8	SERPINE1, KDR, CD36, MMP14, MMP2, MMP3
36	cyclosporin a32 42	8.7	BSG, BMP4, LIPC, MTHFR, CFH, CETP
37	creatinine32	7.6	SELE, SERPINA3, VLDLR, CKB, MTHFR, MTR
38	resveratrol32 9 18 9	10.5	BSG, VEGFA, PARP1, MMP2, MMP9, MAPK10
39	cytochalasin d32 42	8.4	VTN, SELE, CD36, ITGB2, MMP14, MMP2
40	cholesterol32 9 18 9	10.4	VTN, SELE, SERPINE1, SERPINA3, VLDLR, BSG
41	paclitaxel32 34 9 9	9.8	VEGFA, CLU, PARP1, KDR, ITGB2, MKI67
42	pdtc32	6.8	SELE, PARP1, MMP2, MMP9, IL18, IL1A
43	estrogen32	6.7	SERPINE1, SERPINA3, BSG, NAT2, VEGFC, BMP4
44	troglitazone32 42 9 9	9.5	SELE, SERPINE1, CFD, CD36, MMP2, MMP3
45	thymidine32 18	7.5	VEGFC, BMP4, CLU, KDR, MTHFR, ITGA5
46	pd 98,05932	6.1	VTN, SERPINE1, VEGFC, BMP4, PARP1, ITGAM
47	herbimycin a32 42	6.9	VTN, SELE, CD36, ITGB2, MMP14, MMP2
48	genistein32 9 18 9	6.8	SELE, SERPINE1, VEGFA, PARP1, KDR, CD36
49	dexamethasone32 42 34 9 9	7.8	VTN, SERPINF1, SERPINE1, SERPINA3, NAT2, VEGFA
50	retinoic acid32 42 18	5.7	VTN, SERPINF1, SERPINE1, SERPINA3, VEGFC, BMP4

Cellular components related to age related macular degeneration according to GeneDecks:

(show all 11)

id	Name	GO ID	Score	Top Affiliating Genes
1	membrane attack complex	GO:005579	10.7	C8B, C8A, C5, C7, C9, C6
2	extracellular matrix	GO:031012	10.7	HTRA1, HMCN1, PLAT, COL8A1, COL18A1, TIMP3
3	proteinaceous extracellular matrix	GO:005578	10.5	IMPG2, FBLN5, CTGF, ELN, OPTC, EFEMP1
4	membrane	GO:016020	9.8	FADS1, IGF1R, HLA-DQB1, HLA-DRB1, ABCA4, TLR3
5	external side of plasma membrane	GO:009897	9.7	CXCR4, THY1, TLR4, ACE, CR2, HLA-DRB1
6	platelet alpha granule lumen	GO:031093	9.5	EGF, VEGFB, VEGFA, SERPING1, SERPINE1, VEGFC
7	integral to plasma membrane	GO:005887	9.3	HFE, C9, ABCA4, ABCA1, RHO, CR1
8	cell surface	GO:009986	9.0	IL1A, APP, CR1, PLAT, TLR3, CD46
9	plasma membrane	GO:005886	8.1	CR2, PLEKHA1, RPE65, RHO, C4BPA, C4BPB
10	extracellular region	GO:005576	7.5	MASP2, FGA, FMOD, MMP9, MMP7, MMP3
11	extracellular space	GO:005615	7.4	IGF1, IL8, IL6, IL1B, IL1A, IL18

Biological processes related to age related macular degeneration according to GeneDecks:

(show top 50)    (show all 53)

id	Name	GO ID	Score	Top Affiliating Genes
1	visual perception	GO:007601	11.7	RPE65, COL18A1, ABCA4, TIMP3, PRPH2, RLBP1
2	complement activation	GO:006956	11.6	C8B, C8A, C3, C5, CLU, C7
3	complement activation, alternative pathway	GO:006957	11.4	C5, C7, C9, CFP, CFHR5, CFH
4	complement activation, classical pathway	GO:006958	11.1	CR1, MASP2, CD46, CD55, CFI, CLU
5	regulation of complement activation	GO:030449	11.0	C3, C4BPB, C4BPA, C2, CR1, CD46
6	cytolysis	GO:019835	11.0	C8B, C6, C9, C7, C5, C8A
7	reverse cholesterol transport	GO:043691	10.9	ABCA1, APOE, CETP, SCARB1, CLU, LIPC
8	response to stimulus	GO:050896	10.9	RPE65, CRYBB2, NRL, HMCN1, RAX2, RDH8
9	microglial cell activation involved in immune response	GO:002282	10.9	CX3CR1, TLR7, TLR4, TLR3
10	cholesterol metabolic process	GO:008203	10.7	ABCA1, PPARD, CAT, APOE, APOB, CETP
11	positive regulation of inflammatory response	GO:050729	10.7	TLR7, TLR4, TLR3, AGTR1, CCL24, CCR2
12	positive regulation of vascular endothelial growth factor receptor signaling pathway	GO:030949	10.6	HIF1A, IL1B, FLT1, ITGA5, VEGFB, VEGFA
13	positive regulation of endothelial cell proliferation	GO:001938	10.6	CCL11, CCR3, CCL24, F3, HIF1A, CCL2
14	vascular endothelial growth factor receptor signaling pathway	GO:048010	10.6	CCL2, FLT1, KDR, VEGFC, VEGFB, VEGFA
15	glutathione metabolic process	GO:006749	10.6	SOD1, G6PD, GPX3, GPX1, GSTT1, GSTP1
16	cellular iron ion homeostasis	GO:006879	10.5	CP, SOD1, TF, HFE, HIF1A, HEPH
17	positive regulation of interleukin-8 production	GO:032757	10.5	TLR7, TLR4, TLR3, IL1B, IL18, SERPINE1
18	positive regulation of cell division	GO:051781	10.3	PROK1, CAT, IL1B, IL1A, FGF2, VEGFC
19	positive chemotaxis	GO:050918	10.3	FGF2, BMP4, VEGFC, VEGFB, VEGFA
20	chemotaxis	GO:006935	10.3	C5AR1, C5, CX3CR1, CCL24, CCR3, CCL11
21	xenobiotic metabolic process	GO:006805	10.3	AHR, CYP46A1, CYP2D6, CYP2E1, CYP1A2, CYP1A1
22	extracellular matrix organization	GO:030198	10.3	COL10A1, COL8A1, COL18A1, ELN, GFAP, ERCC2
23	positive regulation of chemokine production	GO:032722	10.2	TLR7, TLR4, TLR3, HIF1A, IL6, IL18
24	positive regulation vascular endothelial growth factor production	GO:010575	10.2	C3, C5, HIF1A, IL1B, IL1A
25	lipoprotein metabolic process	GO:042157	10.1	ABCA1, PPARA, APOE, APOB, CETP, SCARB1
26	positive regulation of cell migration	GO:030335	10.1	F3, IGF1R, CCL24, CCL11, CCL26, FLT1
27	innate immune response	GO:045087	10.1	PPARG, CLU, SERPING1, CFB, CFD, CFH
28	immune response	GO:006955	10.0	HLA-DQB1, HLA-DRB1, CR2, HFE, TLR4, C5AR1
29	negative regulation of macrophage derived foam cell differentiation	GO:010745	10.0	ABCA1, CRP, PPARA, PPARG, CETP
30	defense response to Gram-negative bacterium	GO:050829	10.0	TLR4, NOS2, IL6, MMP7, SERPINE1
31	positive regulation of ERK1 and ERK2 cascade	GO:070374	9.9	TLR4, CTGF, IL1B, IL1A, FGF2, KDR
32	positive regulation of angiogenesis	GO:045766	9.8	VEGFA, SERPINE1, KDR, CX3CR1, HIF1A, F3
33	positive regulation of peptidyl-tyrosine phosphorylation	GO:050731	9.8	TLR4, IGF1, IL6, ITGA5, CD36, VEGFB
34	wound healing	GO:042060	9.7	PPARD, PPARA, IL1B, IL1A, FGF2, FMOD
35	proteolysis	GO:006508	9.6	MASP2, MASP1, HTRA1, F2, PLAT, C2
36	positive regulation of interleukin-6 production	GO:032755	9.6	TLR7, TLR4, TLR3, IL6, IL1B, IL1A
37	lipid metabolic process	GO:006629	9.6	G6PD, ABCA1, PPARD, PPARA, PPARG, APOE
38	cellular response to lipopolysaccharide	GO:071222	9.6	CX3CR1, TLR4, ABCA1, NOS2, CCL2, IL8
39	activation of MAPK activity	GO:000187	9.5	C5AR1, C5, SOD1, CXCR4, PROK1, TLR4
40	small molecule metabolic process	GO:044281	9.5	CYCS, CYP2D6, CYP2E1, CYP1A2, CYP1A1, DDC
41	negative regulation of apoptotic process	GO:043066	9.3	SOD2, CX3CR1, KRT18, ERCC2, CAT, IGF1R
42	anti-apoptosis	GO:006916	9.3	IGF1R, IGF1, F3, PSEN1, SOD1, PEA15
43	platelet degranulation	GO:002576	9.3	SOD1, TF, EGF, A2M, PLEK, SERPING1
44	angiogenesis	GO:001525	9.2	CTGF, COL8A1, EGF, HIF1A, THY1, PROK1
45	response to drug	GO:042493	9.1	SOD1, TGIF1, PPARG, SST, GPX3, CCL2
46	inflammatory response	GO:006954	9.0	CCL11, CCR3, CCL24, CRP, AGER, TLR3
47	response to hypoxia	GO:001666	9.0	EPAS1, CXCR4, PSEN2, TLR4, HIF1A, NOS2
48	platelet activation	GO:030168	8.0	EGF, A2M, PLEK, F13A1, F2, F5
49	blood coagulation	GO:007596	7.9	SOD1, TF, C9, EGF, C4BPB, A2M
50	signal transduction	GO:007165	7.4	CCL11, CC2D1A, CCL24, IGF1R, IGF1, PPARG

Molecular functions related to age related macular degeneration according to GeneDecks:

(show all 11)

id	Name	GO ID	Score	Top Affiliating Genes
1	heparin binding	GO:008201	10.6	APOE, APP, ANG, CCL2, CTGF, APOB
2	protein homodimerization activity	GO:042803	10.6	CR2, CRP, CRYBB2, PLEK, NOS2, RPE
3	chemoattractant activity	GO:042056	10.5	FGF2, BMP4, VEGFC, VEGFB, VEGFA
4	copper ion binding	GO:005507	10.2	CP, SOD1, HEPH, F5, LOXL1, ANG
5	integrin binding	GO:005178	10.2	THY1, GFAP, CTGF, IGF1, FBLN5, ITGA5
6	receptor binding	GO:005102	10.2	F2, CAT, DIAPH2, NOS2, NPY, C5
7	serine-type endopeptidase activity	GO:004252	10.1	C2, PLAT, F2, HTRA1, MASP1, MASP2
8	heme binding	GO:020037	9.8	CYP46A1, CYCS, CYP2D6, CYP2E1, CYP1A2, CYP1A1
9	drug binding	GO:008144	9.2	TLR7, ACE, PPARD, PPARA, PPARG, CYP2D6
10	growth factor activity	GO:008083	8.4	IGF1, F2, CTGF, EGF, PROK1, EFEMP1
11	protein binding	GO:005515	4.6	F3, PLEKHA1, NOS2, COL18A1, RHO, KRT18