AMD
MCID: AGR001
MIFTS: 83

Age Related Macular Degeneration (AMD) malady

Eye diseases category

Summaries for Age Related Macular Degeneration

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Sources:
8Disease Ontology, 21Genetics Home Reference, 42NIH Rare Diseases, 33MedlinePlus, 63Wikipedia, 46OMIM, 32MalaCards
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NIH Rare Diseases:42 Age-related macular degeneration (amd) is an eye condition characterized by progressive destruction of the macula. the macula is located in the retina in the eye and enables one to see fine details and perform tasks that require central vision, such as reading and driving. signs and symptoms include vision loss, which usually becomes noticeable in a person's sixties or seventies and tends to worsen over time. there are 2 major types of amd, known as the dry form and the wet form. the dry form accounts for up to 90% of cases and is characterized by slowly progressive vision loss. the wet form is associated with severe vision loss that can worsen rapidly. amd is caused by a combination of genetic and environmental factors, some of which have been identified. increasing age is the most important non-genetic risk factor. the condition appears to run in families in some cases. while there is currently no cure for amd, there are therapies available to help slow the progression of the condition. last updated: 10/7/2013

MalaCards: Age Related Macular Degeneration, also known as age-related macular degeneration, is related to atherosclerosis and kuhnt-junius degeneration. An important gene associated with Age Related Macular Degeneration is APOE (apolipoprotein E), and among its related pathways are Classical antibody-mediated complement activation and Immune response Lectin induced complement pathway. The drugs interferon alfa-2a and interferon alfa-2b and the compounds serine and heparin have been mentioned in the context of this disorder. Affiliated tissues include eye, retina and endothelial, and related mouse phenotypes are cardiovascular system and vision/eye.

Disease Ontology:8 A degeneration of macula and posterior pole that is characterized by a loss of vision in the center of the visual field (the macula) resulting from damage to the retina and resulting in blurring of the sharp central vision.

Genetics Home Reference:21 Age-related macular degeneration is an eye disease that is a leading cause of vision loss in older people in developed countries. The vision loss usually becomes noticeable in a person's sixties or seventies and tends to worsen over time.

MedlinePlus:33 Macular degeneration, or age-related macular degeneration (amd), is a leading cause of vision loss in americans 60 and older. it is a disease that destroys your sharp, central vision. you need central vision to see objects clearly and to do tasks such as reading and driving. amd affects the macula, the part of the eye that allows you to see fine detail. it does not hurt, but it causes cells in the macula to die. there are two types: wet and dry. wet amd happens when abnormal blood vessels grow under the macula. these new blood vessels often leak blood and fluid. wet amd damages the macula quickly. blurred vision is a common early symptom. dry amd happens when the light-sensitive cells in the macula slowly break down. your gradually lose your central vision. a common early symptom is that straight lines appear crooked. regular comprehensive eye exams can detect macular degeneration before the disease causes vision loss. treatment can slow vision loss. it does not restore vision. nih: national eye institute

Wikipedia:63 Macular degeneration, often age-related macular degeneration (AMD or ARMD), is a medical condition that... more...

Description from OMIM:46 613778, 613761, 610698, 611488, 603075 610149, 611378, 611953, 153800, 608895, 613784, 613757 more

Aliases & Classifications for Age Related Macular Degeneration

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Sources:
32MalaCards, 8Disease Ontology, 10DISEASES, 30LifeMap Discovery™, 60UMLS, 42NIH Rare Diseases, 33MedlinePlus, 20GeneTests, 22GTR, 21Genetics Home Reference, 46OMIM, 44Novoseek, 39NCIt, 56SNOMED-CT, 27ICD9CM, 34MeSH
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Classifications:

Malacards categories (disease lists): (See all malacards categories)
Anatomical: Eye diseases


Aliases & Descriptions:

age related macular degeneration 32 8 10 30 60
age-related macular degeneration 8 42 20 22 21
macular degeneration 32 8 42 10 33
age-related maculopathy 42 21 46
macular degeneration, age-related 21 46
amd 42 21
macular degeneration of retina, unspecified 8
senile macular retinal degeneration 8
disorder of macula of retina 60
macular degeneration, senile 44
senile macular degeneration 8
alveolar rhabdomyosarcoma 60
maculopathy age-related 44
armd 21
arm 42


Related Diseases for Age Related Macular Degeneration

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Sources:
17GeneCards, 18GeneDecks
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Diseases related to Age Related Macular Degeneration via text searches within MalaCards or GeneCards/GeneDecks gene sharing:

(show top 50)    (show all 891)
idRelated DiseaseScoreTop Affiliating Genes
1atherosclerosis30.8C3, SERPINF1, APOE
2kuhnt-junius degeneration30.7HTRA1, PLEKHA1, CFH
3retinal drusen30.7CFH
4hepatitis30.5CFB
5complement deficiency30.5C3
6hemolytic-uremic syndrome30.3CFHR3, CFB, CFH, CFHR1
7atypical hemolytic-uremic syndrome30.3CFHR3, CFHR1
8obesity30.3C3, CFH, CFB, APOE
9membranoproliferative glomerulonephritis30.3C3, CFH
10lupus erythematosus30.3C3
11macular holes30.3SERPINF1
12primary open angle glaucoma30.3ABCA4
13glomerulonephritis30.3CFH, C3
14macular degeneration, age-related, reduced risk of30.2CFHR1, CFB, CFHR3
15hypertension30.1APOE
16thrombocytopenia30.0CFH
17hepatitis b29.8CFB
18night blindness29.5ABCA4
19alveolar rhabdomyosarcoma11.3
20rhabdomyosarcoma11.3
21choroiditis11.2
22retinal degeneration11.2
23retinitis11.2
24eye disease10.9
25stargardt disease10.8
26scotoma10.7
27cataract10.7
28embryonal rhabdomyosarcoma10.7
29diabetic retinopathy10.7
30age-related macular degeneration 110.6
31diabetic macular edema10.6
32glaucoma10.6
33retinal detachment10.6
34orbit alveolar rhabdomyosarcoma10.6
35breast rhabdomyosarcoma10.6
36orbit rhabdomyosarcoma10.5
37sarcoma10.5
38vitelliform macular dystrophy10.5
39refractive error10.5
40retinal disease10.5
41age-related macular degeneration 210.5
42age-related macular degeneration 810.5
43retinitis pigmentosa10.4
44pneumonia10.4
45vascular disease10.4
46age-related macular degeneration 310.4
47age-related macular degeneration 410.4
48age-related macular degeneration 510.4
49age-related macular degeneration 610.4
50age-related macular degeneration 710.4

Graphical network of the top 20 diseases related to Age Related Macular Degeneration:



Diseases related to age related macular degeneration

Clinical Features for Age Related Macular Degeneration

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Sources:
46OMIM
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Clinical features from OMIM:

613778, 613761, 610698, 611488, 603075, 610149, 611378, 611953, 153800, 608895 613784, 613757 more

Drugs & Therapeutics for Age Related Macular Degeneration

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Sources:
5CenterWatch, 41NIH Clinical Center, 6ClinicalTrials, 30LifeMap Discovery™, 60UMLS, 40NDF-RT
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Approved drugs:

Search CenterWatch for Age Related Macular Degeneration

Drug clinical trials:

Search ClinicalTrials for Age Related Macular Degeneration

Search NIH Clinical Center for Age Related Macular Degeneration

Search CenterWatch for Age Related Macular Degeneration

Inferred drug relations via UMLS60/NDF-RT40:

Cell-based therapeutics:


LifeMap Discovery
The database of embryonic development, stem cell research and regenerative medicine
Read about Age Related Macular Degeneration cell therapies at LifeMap Discovery.

Genetic Tests for Age Related Macular Degeneration

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20GeneTests, 22GTR
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Genetic tests related to Age Related Macular Degeneration:

id Genetic test Affiliating Genes
1 Age-Related Macular Degeneration20 22 ABCA4, ARMS2, C2, C3, CFB, CFH, ERCC6, FBLN5, HMCN1, HTRA1 (show all 12)

MT-ND2, RAX2

Anatomical Context for Age Related Macular Degeneration

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30LifeMap Discovery™, 32MalaCards
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MalaCards organs/tissues related to Age Related Macular Degeneration:

32
Eye, Retina, Endothelial, Bone, Testes, T cells, Brain, Kidney, Skin, Monocytes, Liver

LifeMap Discovery
The database of embryonic development, stem cell research and regenerative medicine

Cells/anatomical compartments in embryo or adult related to Age Related Macular Degeneration:
id TissueAnatomical CompartmentCell Relevance
1 EyeOuter Nuclear LayerMature L Cone Cells Potential therapeutic candidate, affected by disease
2 EyeOuter Nuclear LayerMature M Cone Cells Potential therapeutic candidate, affected by disease
3 EyeRetinal Pigmented EpitheliumMature Retinal Pigmented Epithelium Cells Potential therapeutic candidate, affected by disease
4 EyeOuter Nuclear LayerMature Rod Cells Potential therapeutic candidate, affected by disease
5 EyeOuter Nuclear LayerMature S Cone Cells Potential therapeutic candidate, affected by disease
6 EyeRetinal Pigmented EpitheliumRetinal Pigmented Epithelium Progenitor Cells Potential therapeutic candidate

Animal Models for Age Related Macular Degeneration or affiliated genes

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36MGI
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MGI Mouse Phenotypes related to Age Related Macular Degeneration:

36
idDescriptionMGI Source AccessionScoreTop Affiliating Genes
1MP:000538511.5C3, C1QTNF5, HTRA1, FHL1, APOE, OPTC
2MP:000539111.1C1QTNF5, HTRA1, FHL1, APOE, OPTC, ABCA4
3MP:000118610.9SERPINF1, ABCA4, APOE, C1QTNF5

Publications for Age Related Macular Degeneration

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50PubMed
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Articles related to Age Related Macular Degeneration:

(show top 50)    (show all 1163)
idTitleAuthorsYear
1
Intravitreal Aflibercept Injection for Neovascular Age-related Macular Degeneration: Ninety-Six-Week Results of the VIEW Studies. (24084500)
2014
2
Complement inhibitors for age-related macular degeneration. (24431152)
2014
3
Influence of TIMP3/SYN3 polymorphisms on the phenotypic presentation of age-related macular degeneration. (23422939)
2013
4
One-year outcome of ranibizumab for neovascular age-related macular degeneration: a thorough analysis in a real-world clinical setting. (24242222)
2013
5
Chromosome 10q26 locus and age-related macular degeneration: AA progress update. (24291204)
2013
6
Cone structure imaged with adaptive optics scanning laser ophthalmoscopy in eyes with nonneovascular age-related macular degeneration. (24135755)
2013
7
Clinical outcomes after switching treatment from intravitreal ranibizumab to aflibercept in neovascular age-related macular degeneration. (24362854)
2013
8
Role of antioxidant enzymes and small molecular weight antioxidants in the pathogenesis of age-related macular degeneration (AMD). (24057278)
2013
9
Association of dehydroepiandrosterone sulfate, serum lipids, C-reactive protein and body mass index with age-related macular degeneration. (23377999)
2013
10
Relationship between macular pigment and visual acuity in eyes with early age-related macular degeneration. (23575039)
2013
11
Is aspirin intake associated with early age-related macular degeneration? The Singapore Indian Eye Study. (23486919)
2013
12
Levels of aqueous humor trace elements in patients with non-exsudative age-related macular degeneration: a case-control study. (23457607)
2013
13
Prediction of age-related macular degeneration in the general population: the Three Continent AMD Consortium. (24120328)
2013
14
Current trends in the rehabilitation of age related macular degeneration: IOL-VIP a promising future. (24269444)
2013
15
Is lipoxins Aa88 a better alternative to anti-VEGF and anti-TNF-I+ antibody to prevent and treat age-related macular degeneration, diabetic macular edema and retinopathy? (22207123)
2012
16
Aflibercept in wet age-related macular degeneration: a perspective review. (23342231)
2012
17
Ranibizumab for exudative age-related macular degeneration in eyes previously treated with alternative vascular endothelial growth factor inhibitors. (20307035)
2010
18
Incorporating prior knowledge to facilitate discoveries in a genome-wide association study on age-related macular degeneration. (20181037)
2010
19
Prospective study of common variants in the retinoic acid receptor-related orphan receptor I+ gene and risk of neovascular age-related macular degeneration. (21060049)
2010
20
R102G polymorphism of the C3 gene associated with exudative age-related macular degeneration in a French population. (20664795)
2010
21
Polymorphisms in CFH, HTRA1 and CX3CR1 confer risk to exudative age-related macular degeneration in Han Chinese. (20538655)
2010
22
Complement component 3 (C3) haplotypes and risk of advanced age-related macular degeneration. (19234341)
2009
23
Analyses of single nucleotide polymorphisms and haplotype linkage of LOC387715 and the HTRA1 gene in exudative age-related macular degeneration in a Chinese cohort. (19491722)
2009
24
Complement component C3 and risk of age-related macular degeneration. (19168221)
2009
25
Polymorphisms in C2, CFB and C3 are associated with progression to advanced age related macular degeneration associated with visual loss. (19015224)
2009
26
Complement factor H Y402H and C-reactive protein polymorphism and photodynamic therapy response in age-related macular degeneration. (19692124)
2009
27
The Y402H variant of complement factor H is associated with age-related macular degeneration but not with diabetic retinal disease in the Go-DARTS study. (19646183)
2009
28
Association of complement factor H and LOC387715 genotypes with response of exudative age-related macular degeneration to photodynamic therapy. (18292785)
2009
29
Age-related macular degeneration is associated with the HLA-Cw*0701 Genotype and the natural killer cell receptor AA haplotype. (18515573)
2008
30
Genotype-phenotype correlation of age-related macular degeneration: influence of complement factor H polymorphism. (18211923)
2008
31
Extreme retinal remodeling triggered by light damage: implications for age related macular degeneration. (18483561)
2008
32
Pegaptanib sodium for the treatment of age-related macular degeneration. (18220500)
2008
33
Toll-like receptor 3 and geographic atrophy in age-related macular degeneration. (18753640)
2008
34
Case-control genetic association study of fibulin-6 (FBLN6 or HMCN1) variants in age-related macular degeneration (AMD). (17216616)
2007
35
Emerging therapies for the treatment of neovascular age-related macular degeneration and diabetic macular edema. (17628122)
2007
36
Inherited complement regulatory protein deficiency predisposes to human disease in acute injury and chronic inflammatory statesthe examples of vascular damage in atypical hemolytic uremic syndrome and debris accumulation in age-related macular degeneration. (17981206)
2007
37
Complement C3 variant and the risk of age-related macular degeneration. (17634448)
2007
38
Murine ccl2/cx3cr1 deficiency results in retinal lesions mimicking human age-related macular degeneration. (17652758)
2007
39
Association between apolipoprotein E polymorphisms and age-related macular degeneration: A HuGE review and meta-analysis. (16916985)
2006
40
No association between complement factor H gene polymorphism and exudative age-related macular degeneration in Japanese. (16710702)
2006
41
Age-related macular degeneration: its association with the epsilon4 allele of the apolipoprotein E gene]. (16450255)
2006
42
Pigment epithelium-derived factor (PEDF) and vascular endothelial growth factor (VEGF) in aged human choroid and eyes with age-related macular degeneration. (16019000)
2006
43
Progression of age-related macular degeneration: prospective assessment of C-reactive protein, interleukin 6, and other cardiovascular biomarkers. (15955978)
2005
44
Cholesterol and age-related macular degeneration: is there a link? (15059717)
2004
45
Cone dysfunction in patients with late-onset cone dystrophy and age-related macular degeneration. (14609911)
2003
46
Allelic variation in the VMD2 gene in best disease and age-related macular degeneration. (10798642)
2000
47
Drusen associated with aging and age-related macular degeneration contain proteins common to extracellular deposits associated with atherosclerosis, elastosis, amyloidosis, and dense deposit disease. (10783137)
2000
48
Distribution of growth factors in subfoveal neovascular membranes in age-related macular degeneration and presumed ocular histoplasmosis syndrome. (7661200)
1995
49
Growth factor localization in choroidal neovascular membranes of age-related macular degeneration. (7519180)
1994
50
Contrast sensitivity peripheral to an absolute central scotoma in age-related macular degeneration and the influence of a yellow or an orange filter. (8299504)
1993

Genetic Variations for Age Related Macular Degeneration

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Sources:
62UniProtKB/Swiss-Prot
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Genetic disease variations for Age Related Macular Degeneration:

62
id Symbol AA change Variation ID SNP ID
1HMCN1p.Gln5345ArgVAR_024818
2HMCN1p.Gln5345ArgVAR_024818

Expression for genes affiliated with Age Related Macular Degeneration

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1BioGPS, 15Gene Expression Omnibus DataSets
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Expression patterns in normal tissues for genes affiliated with Age Related Macular Degeneration

Search GEO for disease gene expression data for Age Related Macular Degeneration.

Pathways for genes affiliated with Age Related Macular Degeneration

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53Reactome, 12EMD Millipore, 29KEGG, 37NCBI BioSystems Database, 51QIAGEN, 55SinoBiological
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Compounds for genes affiliated with Age Related Macular Degeneration

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44Novoseek, 28IUPHAR, 11DrugBank, 24HMDB
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Compounds related to Age Related Macular Degeneration according to GeneCards/GeneDecks:

idCompoundScoreTop Affiliating Genes
1serine4411.2C3, SERPINF1, CFH, CFB, C2, APOE
2heparin44 28 11 2413.9C3, SERPINF1, CFHR1, CFH, APOE
3h2o24410.7HTRA1, APOE, PLEKHA1, ERCC6, SERPINF1

GO Terms for genes affiliated with Age Related Macular Degeneration

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Sources:
16Gene Ontology
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Cellular components related to Age Related Macular Degeneration according to GeneCards/GeneDecks:

idNameGO IDScoreTop Affiliating Genes
1extracellular spaceGO:00561511.3C3, HTRA1, APOE, FBLN5, C2, CFHR3
2extracellular regionGO:00557611.2C3, SERPINF1, CFH, CFB, C2, FBLN5
3extracellular matrixGO:03101210.6HTRA1, FBLN5, HMCN1, SERPINF1

Biological processes related to Age Related Macular Degeneration according to GeneCards/GeneDecks:

idNameGO IDScoreTop Affiliating Genes
1complement activationGO:00695610.9C3, CFHR1, CFH, CFB, C2
2complement activation, alternative pathwayGO:00695710.8C3, CFH, CFB
3regulation of complement activationGO:03044910.6C2, CFB, CFH, C3

Products for genes affiliated with Age Related Macular Degeneration

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  • Antibodies
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Sources for Age Related Macular Degeneration

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3CDC
13ExPASy
14FMA
22GTR
23HGMD
24HMDB
25ICD10
26ICD10 via Orphanet
27ICD9CM
28IUPHAR
29KEGG
34MeSH
35MESH via Orphanet
36MGI
39NCIt
40NDF-RT
43NINDS
44Novoseek
46OMIM
47OMIM via Orphanet
50PubMed
51QIAGEN
57SNOMED-CT via Orphanet
60UMLS
61UMLS via Orphanet