AMD
MCID: AGR001
MIFTS: 70

Age Related Macular Degeneration (AMD) malady

Eye category

Summaries for Age Related Macular Degeneration

Sources:
8Disease Ontology, 21Genetics Home Reference, 43NIH Rare Diseases, 34MedlinePlus, 64Wikipedia, 47OMIM, 33MalaCards
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NIH Rare Diseases:43 Age-related macular degeneration (amd) is an eye condition characterized by progressive destruction of the macula. the macula is located in the retina in the eye and enables one to see fine details and perform tasks that require central vision, such as reading and driving. signs and symptoms include vision loss, which usually becomes noticeable in a person's sixties or seventies and tends to worsen over time. there are 2 major types of amd, known as the dry form and the wet form. the dry form accounts for up to 90% of cases and is characterized by slowly progressive vision loss. the wet form is associated with severe vision loss that can worsen rapidly. amd is caused by a combination of genetic and environmental factors, some of which have been identified. increasing age is the most important non-genetic risk factor. the condition appears to run in families in some cases. while there is currently no cure for amd, there are therapies available to help slow the progression of the condition. last updated: 10/7/2013

MalaCards: Age Related Macular Degeneration, also known as age-related macular degeneration, is related to atherosclerosis and blindness. An important gene associated with Age Related Macular Degeneration is APOE (apolipoprotein E), and among its related pathways are Classical antibody-mediated complement activation and Immune response Lectin induced complement pathway. The drugs interferon alfa-2a and interferon alfa-2b and the compounds serine and heparin have been mentioned in the context of this disorder. Affiliated tissues include bone marrow, retina and endothelial, and related mouse phenotypes are cardiovascular system and vision/eye.

Disease Ontology:8 A degeneration of macula and posterior pole that is characterized by a loss of vision in the center of the visual field (the macula) resulting from damage to the retina and resulting in blurring of the sharp central vision.

Genetics Home Reference:21 Age-related macular degeneration is an eye disease that is a leading cause of vision loss in older people in developed countries. The vision loss usually becomes noticeable in a person's sixties or seventies and tends to worsen over time.

MedlinePlus:34 Macular degeneration, or age-related macular degeneration (amd), is a leading cause of vision loss in americans 60 and older. it is a disease that destroys your sharp, central vision. you need central vision to see objects clearly and to do tasks such as reading and driving. amd affects the macula, the part of the eye that allows you to see fine detail. it does not hurt, but it causes cells in the macula to die. there are two types: wet and dry. wet amd happens when abnormal blood vessels grow under the macula. these new blood vessels often leak blood and fluid. wet amd damages the macula quickly. blurred vision is a common early symptom. dry amd happens when the light-sensitive cells in the macula slowly break down. your gradually lose your central vision. a common early symptom is that straight lines appear crooked. regular comprehensive eye exams can detect macular degeneration before the disease causes vision loss. treatment can slow vision loss. it does not restore vision. nih: national eye institute

Wikipedia:64 Macular degeneration, often age-related macular degeneration (AMD or ARMD), is a medical condition that... more...

Description from OMIM:47 613778, 613761, 610698, 611488, 603075 610149, 611378, 611953, 153800, 608895, 613784, 613757 more

Aliases & Classifications for Age Related Macular Degeneration

Sources:
33MalaCards, 8Disease Ontology, 43NIH Rare Diseases, 20GeneTests, 22GTR, 21Genetics Home Reference, 47OMIM, 10DISEASES, 45Novoseek, 34MedlinePlus, 31LifeMap Discovery™, 61UMLS, 40NCIt, 57SNOMED-CT, 27ICD9CM, 35MeSH
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Classifications:

Malacards categories (disease lists): (See all malacards categories)
Anatomical: Eye


Aliases & Descriptions:

age related macular degeneration 33 8 10 31 61
age-related macular degeneration 8 43 20 22 21
macular degeneration 33 8 43 10 34
age-related maculopathy 43 21 47
macular degeneration, age-related 21 47
amd 43 21
macular degeneration of retina, unspecified 8
senile macular retinal degeneration 8
macular degeneration, senile 45
disorder of macula of retina 61
senile macular degeneration 8
alveolar rhabdomyosarcoma 61
maculopathy age-related 45
armd 21
arm 43


Related Diseases for Age Related Macular Degeneration

Sources:
17GeneCards, 18GeneDecks
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Diseases related to Age Related Macular Degeneration via text searches within MalaCards or GeneCards/GeneDecks gene sharing:

(show top 50)    (show all 830)
idRelated DiseaseScoreTop Affiliating Genes
1atherosclerosis30.8C3, SERPINF1, APOE
2blindness30.8HTRA1, ABCA4, PLEKHA1, CFH, SERPINF1
3retinal drusen30.8CFH
4kuhnt-junius degeneration30.7HTRA1, PLEKHA1, CFH
5hemolytic-uremic syndrome30.3CFHR3, CFB, CFH, CFHR1
6atypical hemolytic-uremic syndrome30.3CFHR3, CFHR1
7membranoproliferative glomerulonephritis30.3C3, CFH
8primary open angle glaucoma30.3ABCA4
9macular degeneration, age-related, reduced risk of30.2CFHR1, CFB, CFHR3
10thrombocytopenia30.1CFH
11stargardt disease10.8
12stargardt macular degeneration10.8
13char syndrome10.7
14charles bonnet syndrome10.7
15scotoma10.7
16age-related macular degeneration 110.7
17diabetic macular edema10.6
18central serous chorioretinopathy10.6
19orbit alveolar rhabdomyosarcoma10.6
20breast rhabdomyosarcoma10.6
21n syndrome10.6
22macular dystrophy10.6
23vitelliform macular dystrophy10.5
24age-related macular degeneration 210.5
25age-related macular degeneration 810.5
26retinitis pigmentosa10.5
27vascular disease10.5
28late-onset retinal degeneration10.5
29age-related macular degeneration 310.5
30age-related macular degeneration 410.5
31age-related macular degeneration 510.5
32age-related macular degeneration 610.5
33age-related macular degeneration 710.5
34age-related macular degeneration 910.5
35juvenile macular degeneration and hypotrichosis10.5
36short syndrome10.4
37cutis laxa10.4
38alzheimer's disease10.4
39vitreous detachment10.4
40uveitis10.4
41adult-onset vitelliform macular dystrophy10.4
42soft tissue sarcoma10.4
43rhabdomyosarcoma 2, alveolar10.4
44retinal degeneration with nanophthalmos, cystic macular degeneration, and angle closure glaucoma10.4
45best vitelliform macular dystrophy10.3
46alopecia macular degeneration growth retardation10.3
47myopic macular degeneration10.3
48primary ciliary dyskinesia10.3
49macular dystrophy, concentric annular10.3
50maculopathy, impg2-related10.3

Graphical network of the top 20 diseases related to Age Related Macular Degeneration:



Diseases related to age related macular degeneration

Clinical Features for Age Related Macular Degeneration

Sources:
47OMIM
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Clinical features from OMIM:

613778, 613761, 610698, 611488, 603075, 610149, 611378, 611953, 153800, 608895 613784, 613757 more

Drugs & Therapeutics for Age Related Macular Degeneration

Sources:
5CenterWatch, 42NIH Clinical Center, 6ClinicalTrials, 31LifeMap Discovery™, 61UMLS, 41NDF-RT
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Approved drugs:

Search CenterWatch for Age Related Macular Degeneration

Drug clinical trials:

Search ClinicalTrials for Age Related Macular Degeneration

Search NIH Clinical Center for Age Related Macular Degeneration

Search CenterWatch for Age Related Macular Degeneration

Inferred drug relations via UMLS61/NDF-RT41:

Cell-based therapeutics:


LifeMap Discovery
The database of embryonic development, stem cell research and regenerative medicine
Read about Age Related Macular Degeneration cell therapies at LifeMap Discovery.

Genetic Tests for Age Related Macular Degeneration

Sources:
20GeneTests, 22GTR
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Genetic tests related to Age Related Macular Degeneration:

id Genetic test Affiliating Genes
1 Age-related Macular Degeneration20 22 C3, ERCC6, CFH, CFB, HMCN1, RAX2, ABCA4, C2, MT-ND2, FBLN5 (show all 12)

ARMS2, HTRA1

Anatomical Context for Age Related Macular Degeneration

Sources:
31LifeMap Discovery™, 33MalaCards
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MalaCards organs/tissues related to Age Related Macular Degeneration:

33
Bone marrow, Retina, Endothelial

LifeMap Discovery
The database of embryonic development, stem cell research and regenerative medicine

Cells/anatomical compartments in embryo or adult related to Age Related Macular Degeneration:
id TissueAnatomical CompartmentCell Relevance
1 EyeOuter Nuclear LayerMature L Cone Cells Potential therapeutic candidate, affected by disease
2 EyeOuter Nuclear LayerMature M Cone Cells Potential therapeutic candidate, affected by disease
3 EyeRetinal Pigmented EpitheliumMature Retinal Pigmented Epithelium Cells Potential therapeutic candidate, affected by disease
4 EyeOuter Nuclear LayerMature Rod Cells Potential therapeutic candidate, affected by disease
5 EyeOuter Nuclear LayerMature S Cone Cells Potential therapeutic candidate, affected by disease
6 EyeRetinal Pigmented EpitheliumRetinal Pigmented Epithelium Progenitor Cells Potential therapeutic candidate

Animal Models for Age Related Macular Degeneration or affiliated genes

Sources:
37MGI, 28inGenious Targeting Laboratory
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MGI Mouse Phenotypes related to Age Related Macular Degeneration:

37
idDescriptionMGI Source AccessionScoreTop Affiliating Genes
1MP:000538511.5C3, C1QTNF5, HTRA1, FHL1, APOE, OPTC
2MP:000539111.1ABCA4, OPTC, APOE, FHL1, HTRA1, ERCC6
3MP:000118610.9C1QTNF5, APOE, SERPINF1, ABCA4

Publications for Age Related Macular Degeneration

Sources:
51PubMed
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Articles related to Age Related Macular Degeneration:

idTitleAuthorsYear
1
Vascular disrupting agent for neovascular age related macular degeneration: a pilot study of the safety and efficacy of intravenous combretastatin A-4 phosphate. (23316779)
2013
2
Clinical Utilization of Anti-VEGF Agents and Disease Monitoring in Neovascular Age-Related Macular Degeneration. (24388973)
2013
3
Therapies for neovascular age-related macular degeneration: current approaches and pharmacologic agents in development. (24319688)
2013
4
Combination therapy for neovascular age-related macular degeneration refractory to anti-vascular endothelial growth factor agents. (23714319)
2013
5
Autophagy and exosomes in the aged retinal pigment epithelium: possible relevance to drusen formation and age-related macular degeneration. (19129916)
2009
6
Introduction: Understanding the role of angiogenesis and antiangiogenic agents in age-related macular degeneration. (19800534)
2009
7
Pigment epithelium-derived factor (PEDF) and vascular endothelial growth factor (VEGF) in aged human choroid and eyes with age-related macular degeneration. (16019000)
2006
8
Localisation of SDF-1 and its receptor CXCR4 in retina and choroid of aged human eyes and in eyes with age related macular degeneration. (16597663)
2006

Genetic Variations for Age Related Macular Degeneration

Expression for genes affiliated with Age Related Macular Degeneration

Sources:
1BioGPS, 15Gene Expression Omnibus DataSets
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Expression patterns in normal tissues for genes affiliated with Age Related Macular Degeneration

Search GEO for disease gene expression data for Age Related Macular Degeneration.

Pathways for genes affiliated with Age Related Macular Degeneration

Sources:
54Reactome, 12EMD Millipore, 30KEGG, 38NCBI BioSystems Database, 52QIAGEN, 56SinoBiological
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Compounds for genes affiliated with Age Related Macular Degeneration

Sources:
45Novoseek, 29IUPHAR, 11DrugBank, 24HMDB
See all sources

Compounds related to Age Related Macular Degeneration according to GeneCards/GeneDecks:

idCompoundScoreTop Affiliating Genes
1serine4511.2HTRA1, APOE, C2, CFB, CFH, SERPINF1
2heparin45 29 11 2413.9SERPINF1, APOE, CFH, C3, CFHR1
3h2o24510.7APOE, PLEKHA1, ERCC6, SERPINF1, HTRA1

GO Terms for genes affiliated with Age Related Macular Degeneration

Sources:
16Gene Ontology
See all sources

Cellular components related to Age Related Macular Degeneration according to GeneCards/GeneDecks:

idNameGO IDScoreTop Affiliating Genes
1extracellular spaceGO:00561511.3C3, HTRA1, APOE, FBLN5, C2, CFHR3
2extracellular regionGO:00557611.2C3, SERPINF1, CFH, CFB, C2, FBLN5
3extracellular matrixGO:03101210.6HTRA1, FBLN5, HMCN1, SERPINF1

Biological processes related to Age Related Macular Degeneration according to GeneCards/GeneDecks:

idNameGO IDScoreTop Affiliating Genes
1complement activationGO:00695610.9C3, CFHR1, CFH, CFB, C2
2complement activation, alternative pathwayGO:00695710.8C3, CFH, CFB
3regulation of complement activationGO:03044910.6C2, CFB, CFH, C3

Products for genes affiliated with Age Related Macular Degeneration

  • Antibodies
  • Proteins
  • Lysates
  • Antibodies

Sources for Age Related Macular Degeneration

3CDC
13ExPASy
14FMA
22GTR
23HGMD
24HMDB
25ICD10
26ICD10 via Orphanet
27ICD9CM
29IUPHAR
30KEGG
35MeSH
36MESH via Orphanet
37MGI
40NCIt
41NDF-RT
44NINDS
45Novoseek
47OMIM
48OMIM via Orphanet
51PubMed
52QIAGEN
58SNOMED-CT via Orphanet
61UMLS
62UMLS via Orphanet