AMD
MCID: AGR001
MIFTS: 83

Age Related Macular Degeneration (AMD) malady

Eye diseases category

Summaries for Age Related Macular Degeneration

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Sources:
8Disease Ontology, 21Genetics Home Reference, 42NIH Rare Diseases, 33MedlinePlus, 63Wikipedia, 46OMIM, 32MalaCards
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NIH Rare Diseases:42 Age-related macular degeneration (amd) is an eye condition characterized by progressive destruction of the macula. the macula is located in the retina in the eye and enables one to see fine details and perform tasks that require central vision, such as reading and driving. signs and symptoms include vision loss, which usually becomes noticeable in a person's sixties or seventies and tends to worsen over time. there are 2 major types of amd, known as the dry form and the wet form. the dry form accounts for up to 90% of cases and is characterized by slowly progressive vision loss. the wet form is associated with severe vision loss that can worsen rapidly. amd is caused by a combination of genetic and environmental factors, some of which have been identified. increasing age is the most important non-genetic risk factor. the condition appears to run in families in some cases. while there is currently no cure for amd, there are therapies available to help slow the progression of the condition. last updated: 10/7/2013

MalaCards: Age Related Macular Degeneration, also known as age-related macular degeneration, is related to atherosclerosis and kuhnt-junius degeneration. An important gene associated with Age Related Macular Degeneration is APOE (apolipoprotein E), and among its related pathways are Classical antibody-mediated complement activation and Immune response Lectin induced complement pathway. The drugs interferon alfa-2a and interferon alfa-2b and the compounds serine and heparin have been mentioned in the context of this disorder. Affiliated tissues include eye, retina and endothelial, and related mouse phenotypes are cardiovascular system and vision/eye.

Disease Ontology:8 A degeneration of macula and posterior pole that is characterized by a loss of vision in the center of the visual field (the macula) resulting from damage to the retina and resulting in blurring of the sharp central vision.

Genetics Home Reference:21 Age-related macular degeneration is an eye disease that is a leading cause of vision loss in older people in developed countries. The vision loss usually becomes noticeable in a person's sixties or seventies and tends to worsen over time.

MedlinePlus:33 Macular degeneration, or age-related macular degeneration (amd), is a leading cause of vision loss in americans 60 and older. it is a disease that destroys your sharp, central vision. you need central vision to see objects clearly and to do tasks such as reading and driving. amd affects the macula, the part of the eye that allows you to see fine detail. it does not hurt, but it causes cells in the macula to die. there are two types: wet and dry. wet amd happens when abnormal blood vessels grow under the macula. these new blood vessels often leak blood and fluid. wet amd damages the macula quickly. blurred vision is a common early symptom. dry amd happens when the light-sensitive cells in the macula slowly break down. your gradually lose your central vision. a common early symptom is that straight lines appear crooked. regular comprehensive eye exams can detect macular degeneration before the disease causes vision loss. treatment can slow vision loss. it does not restore vision. nih: national eye institute

Wikipedia:63 Macular degeneration, often age-related macular degeneration (AMD or ARMD), is a medical condition that... more...

Description from OMIM:46 613778, 613761, 610698, 611488, 603075 610149, 611378, 611953, 153800, 608895, 613784, 613757 more

Aliases & Classifications for Age Related Macular Degeneration

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Sources:
32MalaCards, 8Disease Ontology, 10DISEASES, 30LifeMap Discovery™, 60UMLS, 42NIH Rare Diseases, 33MedlinePlus, 20GeneTests, 22GTR, 21Genetics Home Reference, 46OMIM, 44Novoseek, 39NCIt, 56SNOMED-CT, 27ICD9CM, 34MeSH
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Classifications:

Malacards categories (disease lists): (See all malacards categories)
Anatomical: Eye diseases


Aliases & Descriptions:

age related macular degeneration 32 8 10 30 60
age-related macular degeneration 8 42 20 22 21
macular degeneration 32 8 42 10 33
age-related maculopathy 42 21 46
macular degeneration, age-related 21 46
amd 42 21
macular degeneration of retina, unspecified 8
senile macular retinal degeneration 8
disorder of macula of retina 60
macular degeneration, senile 44
senile macular degeneration 8
alveolar rhabdomyosarcoma 60
maculopathy age-related 44
armd 21
arm 42


Related Diseases for Age Related Macular Degeneration

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Sources:
17GeneCards, 18GeneDecks
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Diseases related to Age Related Macular Degeneration via text searches within MalaCards or GeneCards/GeneDecks gene sharing:

(show top 50)    (show all 891)
idRelated DiseaseScoreTop Affiliating Genes
1atherosclerosis30.8C3, SERPINF1, APOE
2kuhnt-junius degeneration30.7HTRA1, PLEKHA1, CFH
3retinal drusen30.7CFH
4hepatitis30.5CFB
5complement deficiency30.5C3
6hemolytic-uremic syndrome30.3CFHR3, CFB, CFH, CFHR1
7atypical hemolytic-uremic syndrome30.3CFHR3, CFHR1
8obesity30.3C3, CFH, CFB, APOE
9membranoproliferative glomerulonephritis30.3C3, CFH
10lupus erythematosus30.3C3
11macular holes30.3SERPINF1
12primary open angle glaucoma30.3ABCA4
13glomerulonephritis30.3CFH, C3
14macular degeneration, age-related, reduced risk of30.2CFHR1, CFB, CFHR3
15hypertension30.1APOE
16thrombocytopenia30.0CFH
17hepatitis b29.8CFB
18night blindness29.5ABCA4
19alveolar rhabdomyosarcoma11.3
20rhabdomyosarcoma11.3
21choroiditis11.2
22retinal degeneration11.2
23retinitis11.2
24eye disease10.9
25stargardt disease10.8
26scotoma10.7
27cataract10.7
28embryonal rhabdomyosarcoma10.7
29diabetic retinopathy10.7
30age-related macular degeneration 110.6
31diabetic macular edema10.6
32glaucoma10.6
33retinal detachment10.6
34orbit alveolar rhabdomyosarcoma10.6
35breast rhabdomyosarcoma10.6
36orbit rhabdomyosarcoma10.5
37sarcoma10.5
38vitelliform macular dystrophy10.5
39refractive error10.5
40retinal disease10.5
41age-related macular degeneration 210.5
42age-related macular degeneration 810.5
43retinitis pigmentosa10.4
44pneumonia10.4
45vascular disease10.4
46age-related macular degeneration 310.4
47age-related macular degeneration 410.4
48age-related macular degeneration 510.4
49age-related macular degeneration 610.4
50age-related macular degeneration 710.4

Graphical network of the top 20 diseases related to Age Related Macular Degeneration:



Diseases related to age related macular degeneration

Clinical Features for Age Related Macular Degeneration

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Sources:
46OMIM
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Clinical features from OMIM:

613778, 613761, 610698, 611488, 603075, 610149, 611378, 611953, 153800, 608895 613784, 613757 more

Drugs & Therapeutics for Age Related Macular Degeneration

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Sources:
5CenterWatch, 41NIH Clinical Center, 6ClinicalTrials, 30LifeMap Discovery™, 60UMLS, 40NDF-RT
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Approved drugs:

Search CenterWatch for Age Related Macular Degeneration

Drug clinical trials:

Search ClinicalTrials for Age Related Macular Degeneration

Search NIH Clinical Center for Age Related Macular Degeneration

Search CenterWatch for Age Related Macular Degeneration

Inferred drug relations via UMLS60/NDF-RT40:

Cell-based therapeutics:


LifeMap Discovery
The database of embryonic development, stem cell research and regenerative medicine
Read about Age Related Macular Degeneration cell therapies at LifeMap Discovery.

Genetic Tests for Age Related Macular Degeneration

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20GeneTests, 22GTR
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Genetic tests related to Age Related Macular Degeneration:

id Genetic test Affiliating Genes
1 Age-Related Macular Degeneration20 22 ABCA4, ARMS2, C2, C3, CFB, CFH, ERCC6, FBLN5, HMCN1, HTRA1 (show all 12)

MT-ND2, RAX2

Anatomical Context for Age Related Macular Degeneration

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30LifeMap Discovery™, 32MalaCards
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MalaCards organs/tissues related to Age Related Macular Degeneration:

32
Eye, Retina, Endothelial, Bone, Testes, T cells, Brain, Kidney, Skin, Monocytes, Liver

LifeMap Discovery
The database of embryonic development, stem cell research and regenerative medicine

Cells/anatomical compartments in embryo or adult related to Age Related Macular Degeneration:
id TissueAnatomical CompartmentCell Relevance
1 EyeOuter Nuclear LayerMature L Cone Cells Potential therapeutic candidate, affected by disease
2 EyeOuter Nuclear LayerMature M Cone Cells Potential therapeutic candidate, affected by disease
3 EyeRetinal Pigmented EpitheliumMature Retinal Pigmented Epithelium Cells Potential therapeutic candidate, affected by disease
4 EyeOuter Nuclear LayerMature Rod Cells Potential therapeutic candidate, affected by disease
5 EyeOuter Nuclear LayerMature S Cone Cells Potential therapeutic candidate, affected by disease
6 EyeRetinal Pigmented EpitheliumRetinal Pigmented Epithelium Progenitor Cells Potential therapeutic candidate

Animal Models for Age Related Macular Degeneration or affiliated genes

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36MGI
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MGI Mouse Phenotypes related to Age Related Macular Degeneration:

36
idDescriptionMGI Source AccessionScoreTop Affiliating Genes
1MP:000538511.5C3, C1QTNF5, HTRA1, FHL1, APOE, OPTC
2MP:000539111.1C1QTNF5, HTRA1, FHL1, APOE, OPTC, ABCA4
3MP:000118610.9SERPINF1, ABCA4, APOE, C1QTNF5

Publications for Age Related Macular Degeneration

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50PubMed
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Articles related to Age Related Macular Degeneration:

(show top 50)    (show all 1163)
idTitleAuthorsYear
1
Intravitreal Aflibercept for Treatment-Resistant Neovascular Age-related Macular Degeneration. (24144450)
2014
2
PIGMENT EPITHELIAL TEARS ASSOCIATED WITH ANTI-VEGF THERAPY: Incidence, Long-term Visual Outcome, and Relationship with Pigment Epithelial Detachment in Age-related Macular Degeneration. (24296398)
2013
3
Two-year outcomes of pro re nata ranibizumab monotherapy for exudative age-related macular degeneration in Japanese patients. (23620657)
2013
4
Zinc-induced self-association of complement C3b and Factor H: implications for inflammation and age-related macular degeneration. (23661701)
2013
5
Pharmacogenetics for genes associated with age-related macular degeneration in the Comparison of AMD Treatments Trials (CATT). (23337555)
2013
6
Two-year results of reduced-fluence photodynamic therapy combined with intravitreal ranibizumab for typical age-related macular degeneration and polypoidal choroidal vasculopathy. (23413039)
2013
7
Change in Drusen Volume as a Novel Clinical Trial Endpoint for the Study of Complement Inhibition in Age-related Macular Degeneration. (24354307)
2013
8
Long-term effectiveness of ranibizumab for age-related macular degeneration and diabetic macular edema. (23766636)
2013
9
Retinal pigment epithelium tears following intravitreal ranibizumab injection for neovascular age-related macular degeneration. (23844861)
2013
10
Triple therapy for anti-vascular endothelial growth factor nonresponders in neovascular age-related macular degeneration: impact of different photodynamic therapy parameters. (23948986)
2013
11
Immunology of age-related macular degeneration. (23702979)
2013
12
A rare functional haplotype of the P2RX4 and P2RX7 genes leads to loss of innate phagocytosis and confers increased risk of age-related macular degeneration. (23303206)
2013
13
Second reflective band intensity in age-related macular degeneration. (23732057)
2013
14
Superoxide dismutase1 levels in north Indian population with age-related macular degeneration. (24363822)
2013
15
Prevention and treatment of age-related macular degeneration: an update for pharmacists. (24217192)
2013
16
Correlation between subfoveal choroidal thickness and the severity or progression of nonexudative age-related macular degeneration. (24204054)
2013
17
Fundus autofluorescence and microperimetry in progressing geographic atrophy secondary to age-related macular degeneration. (23410728)
2013
18
Prospective audit of exudative age-related macular degeneration: 12-month outcomes in treatment-naive eyes. (23821201)
2013
19
Rheohaemapheresis in the treatment of nonvascular age-related macular degeneration. (23357162)
2013
20
Influence of intravitreal injection of bevacizumab on systemic blood pressure changes in patients with exudative form of age-related macular degeneration. (24305579)
2013
21
Single-session photodynamic therapy combined with intravitreal ranibizumab for neovascular age-related macular degeneration: a comprehensive functional retinal assessment. (23943132)
2013
22
Durable recovery of the macular architecture and functionality of a diagnosed age-related macular degeneration 1 year after a single intravitreal injection of dobesilate. (24225910)
2013
23
Does matrix metalloproteinase-3 polymorphism play a role in age-related macular degeneration in patients with myocardial infarction? (23128460)
2012
24
Homozygosity for the +674C>T polymorphism on VEGF gene is associated with age-related macular degeneration in a Brazilian cohort. (21881842)
2012
25
Relevance of complement factor H-related 1 (CFHR1) genotypes in age-related macular degeneration. (22247456)
2012
26
Anterior uveitis after treatment of age-related macular degeneration with ranibizumab and bevacizumab: uncommon complication. (22927728)
2012
27
Quantitative assessment of age-related macular degeneration using parametric modeling of the leakage transfer function: preliminary results. (23367288)
2012
28
Chlamydia infection status, genotype, and age-related macular degeneration. (22259222)
2012
29
Apolipoprotein E gene and age-related macular degeneration in a Chinese population. (21541275)
2011
30
Vascular endothelial growth factor gene polymorphisms and risk of neovascular age-related macular degeneration in a Chinese cohort. (20847577)
2011
31
Angiogenin in age-related macular degeneration. (21364907)
2011
32
Analysis of SERPING1 and its association with age-related macular degeneration. (19925520)
2011
33
Refractive error and smoking habits in exudative age-related macular degeneration in a hospital-based setting. (19590519)
2010
34
Distribution of the C-460T polymorphism of the vascular endothelial growth factor gene in age-related macular degeneration. (19673440)
2009
35
Decreased serum paraoxonase 1 activity and increased serum homocysteine and malondialdehyde levels in age-related macular degeneration. (19155603)
2009
36
{omega}-3 Long-chain polyunsaturated fatty acid intake and 12-y incidence of neovascular age-related macular degeneration and central geographic atrophy: AREDS report 30, a prospective cohort study from the Age-Related Eye Disease Study. (19812176)
2009
37
Variants in the 10q26 gene cluster (LOC387715 and HTRA1) exhibit enhanced risk of age-related macular degeneration along with CFH in Indian patients. (18436811)
2008
38
Vascular endothelial growth factor gene polymorphisms in age-related macular degeneration. (18378209)
2008
39
Further mapping of 10q26 supports strong association of HTRA1 polymorphisms with age-related macular degeneration. (18207215)
2008
40
Treatment of age-related macular degeneration: focus on ranibizumab. (19668384)
2008
41
A tag-single nucleotide polymorphisms approach to the vascular endothelial growth factor-A gene in age-related macular degeneration. (18079689)
2007
42
Coding and noncoding variants in the CFH gene and cigarette smoking influence the risk of age-related macular degeneration in a Japanese population. (17962488)
2007
43
Emerging therapies for neovascular age-related macular degeneration: state of the art. (17947822)
2007
44
Expression of hypoxia-inducible factor 1alpha and 2alpha in choroidal neovascular membranes associated with age-related macular degeneration. (18024825)
2007
45
Identification of Chlamydia pneumoniae within human choroidal neovascular membranes secondary to age-related macular degeneration. (15909160)
2005
46
Analysis of Hemicentin-1, hOgg1, and E-selectin single nucleotide polymorphisms in age-related macular degeneration. (17057786)
2005
47
MMP-9 microsatellite polymorphism and susceptibility to exudative form of age-related macular degeneration. (15834245)
2005
48
Visual hallucinations and Charles Bonnet syndrome after photodynamic therapy for age related macular degeneration. (12881339)
2003
49
Tamoxifen side effects, age-related macular degeneration (AMD) or cancer associated retinopathy (CAR)? (11681514)
2001
50
Increase in interphotoreceptor matrix gelatinase A (MMP-2) associated with age-related macular degeneration. (9990329)
1998

Genetic Variations for Age Related Macular Degeneration

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Sources:
62UniProtKB/Swiss-Prot
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Genetic disease variations for Age Related Macular Degeneration:

62
id Symbol AA change Variation ID SNP ID
1HMCN1p.Gln5345ArgVAR_024818
2HMCN1p.Gln5345ArgVAR_024818

Expression for genes affiliated with Age Related Macular Degeneration

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1BioGPS, 15Gene Expression Omnibus DataSets
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Expression patterns in normal tissues for genes affiliated with Age Related Macular Degeneration

Search GEO for disease gene expression data for Age Related Macular Degeneration.

Pathways for genes affiliated with Age Related Macular Degeneration

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Sources:
53Reactome, 12EMD Millipore, 29KEGG, 37NCBI BioSystems Database, 51QIAGEN, 55SinoBiological
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Compounds for genes affiliated with Age Related Macular Degeneration

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44Novoseek, 28IUPHAR, 11DrugBank, 24HMDB
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Compounds related to Age Related Macular Degeneration according to GeneCards/GeneDecks:

idCompoundScoreTop Affiliating Genes
1serine4411.2C3, SERPINF1, CFH, CFB, C2, APOE
2heparin44 28 11 2413.9C3, SERPINF1, CFHR1, CFH, APOE
3h2o24410.7HTRA1, APOE, PLEKHA1, ERCC6, SERPINF1

GO Terms for genes affiliated with Age Related Macular Degeneration

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Sources:
16Gene Ontology
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Cellular components related to Age Related Macular Degeneration according to GeneCards/GeneDecks:

idNameGO IDScoreTop Affiliating Genes
1extracellular spaceGO:00561511.3C3, HTRA1, APOE, FBLN5, C2, CFHR3
2extracellular regionGO:00557611.2C3, SERPINF1, CFH, CFB, C2, FBLN5
3extracellular matrixGO:03101210.6HTRA1, FBLN5, HMCN1, SERPINF1

Biological processes related to Age Related Macular Degeneration according to GeneCards/GeneDecks:

idNameGO IDScoreTop Affiliating Genes
1complement activationGO:00695610.9C3, CFHR1, CFH, CFB, C2
2complement activation, alternative pathwayGO:00695710.8C3, CFH, CFB
3regulation of complement activationGO:03044910.6C2, CFB, CFH, C3

Products for genes affiliated with Age Related Macular Degeneration

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  • Antibodies
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Sources for Age Related Macular Degeneration

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3CDC
13ExPASy
14FMA
22GTR
23HGMD
24HMDB
25ICD10
26ICD10 via Orphanet
27ICD9CM
28IUPHAR
29KEGG
34MeSH
35MESH via Orphanet
36MGI
39NCIt
40NDF-RT
43NINDS
44Novoseek
46OMIM
47OMIM via Orphanet
50PubMed
51QIAGEN
57SNOMED-CT via Orphanet
60UMLS
61UMLS via Orphanet