Age Related Macular Degeneration (AMD) malady

Genetic diseases, Rare diseases, Eye diseases categories

Summaries for Age Related Macular Degeneration

About this section

NIH Rare Diseases:42 Age-related macular degeneration (amd) is an eye condition characterized by progressive destruction of the macula. the macula is located in the retina in the eye and enables one to see fine details and perform tasks that require central vision, such as reading and driving. signs and symptoms include vision loss, which usually becomes noticeable in a person's sixties or seventies and tends to worsen over time. there are 2 major types of amd, known as the dry form and the wet form. the dry form accounts for up to 90% of cases and is characterized by slowly progressive vision loss. the wet form is associated with severe vision loss that can worsen rapidly. amd is caused by a combination of genetic and environmental factors, some of which have been identified. increasing age is the most important non-genetic risk factor. the condition appears to run in families in some cases. while there is currently no cure for amd, there are therapies available to help slow the progression of the condition. last updated: 10/7/2013

MalaCards based summary: Age Related Macular Degeneration, also known as age-related macular degeneration, is related to kuhnt-junius degeneration and retinal drusen. An important gene associated with Age Related Macular Degeneration is APOE (apolipoprotein E), and among its related pathways are A-beta Uptake and Degradation and Angiogenesis. The drugs interferon alfa-2a and interferon alfa-2b and the compounds agarose and hyaluronic acid have been mentioned in the context of this disorder. Affiliated tissues include eye, retina and endothelial, and related mouse phenotypes are pigmentation and liver/biliary system.

Disease Ontology:9 A degeneration of macula and posterior pole that is characterized by a loss of vision in the center of the visual field (the macula) resulting from damage to the retina and resulting in blurring of the sharp central vision.

Genetics Home Reference:22 Age-related macular degeneration is an eye disease that is a leading cause of vision loss in older people in developed countries. The vision loss usually becomes noticeable in a person's sixties or seventies and tends to worsen over time.

MedlinePlus:33 Macular degeneration, or age-related macular degeneration (amd), is a leading cause of vision loss in americans 60 and older. it is a disease that destroys your sharp, central vision. you need central vision to see objects clearly and to do tasks such as reading and driving. amd affects the macula, the part of the eye that allows you to see fine detail. it does not hurt, but it causes cells in the macula to die. there are two types: wet and dry. wet amd happens when abnormal blood vessels grow under the macula. these new blood vessels often leak blood and fluid. wet amd damages the macula quickly. blurred vision is a common early symptom. dry amd happens when the light-sensitive cells in the macula slowly break down. your gradually lose your central vision. a common early symptom is that straight lines appear crooked. regular comprehensive eye exams can detect macular degeneration before the disease causes vision loss. treatment can slow vision loss. it does not restore vision. nih: national eye institute

Wikipedia:64 Macular degeneration, often age-related macular degeneration (AMD or ARMD), is a medical condition that... more...

Descriptions from OMIM:46 613761, 608895, 610149, 153800, 610698 613757, 613778, 613784, 611953, 611378, 611488, 603075 more

Aliases & Classifications for Age Related Macular Degeneration

About this section

Age Related Macular Degeneration, Aliases & Descriptions:

Name: Age Related Macular Degeneration 32 31 9 11 61
Age-Related Macular Degeneration 9 42 21 23 22
Macular Degeneration 32 9 42 11 33
Age-Related Maculopathy 42 22 46
Senile Macular Retinal Degeneration 9 61
Macular Degeneration, Age-Related 22 46
Amd 42 22
Macular Degeneration of Retina, Unspecified 9
Disorder of Macula of Retina 61
Macular Degeneration, Senile 44
Senile Macular Degeneration 9
Alveolar Rhabdomyosarcoma 61
Maculopathy Age-Related 44
Armd 22
Arm 42


Malacards categories (disease lists): (See all malacards categories)
Global: Genetic diseases, Rare diseases
Anatomical: Eye diseases

Related Diseases for Age Related Macular Degeneration

About this section

Diseases in the Age Related Macular Degeneration family:

Age-Related Macular Degeneration 1 Age-Related Macular Degeneration 2
Age-Related Macular Degeneration 3 Age-Related Macular Degeneration 4
Age-Related Macular Degeneration 5 Age-Related Macular Degeneration 6
Age-Related Macular Degeneration 7 Age-Related Macular Degeneration 8
Age-Related Macular Degeneration 9 Macular Degeneration, Age-Related, 12
Macular Degeneration, Age-Related, 13 Macular Degeneration, Age-Related, 10
Macular Degeneration, Age-Related, 11

Diseases related to Age Related Macular Degeneration via text searches within MalaCards or GeneCards/GeneDecks gene sharing:

(show top 50)    (show all 158)
idRelated DiseaseScoreTop Affiliating Genes
1kuhnt-junius degeneration31.3HTRA1, PLEKHA1, VEGFA, CFH
2retinal drusen31.2CFH
3atherosclerosis31.1APOE, TIMP3, CX3CR1, C3
4atypical hemolytic-uremic syndrome31.1CFHR3, CFHR1
5membranoproliferative glomerulonephritis31.0C3, CFH
6blindness31.0VEGFA, TIMP3, CFH, HTRA1, PLEKHA1, ABCA4
7macular degeneration, age-related, reduced risk of30.9CFHR1, CFHR3
8hemolytic-uremic syndrome30.9CFHR3, CFH, CFB, CFHR1
9obesity30.7CFB, C3, APOE, CFH
10rheumatoid arthritis30.6TIMP3, CX3CR1, C3, CFB, VEGFA
14eye disease10.9
15stargardt disease10.8
16charles bonnet syndrome10.8
19age-related macular degeneration 110.7
20diabetic retinopathy10.7
21diabetic macular edema10.7
22retinal degeneration10.6
23central serous chorioretinopathy10.6
24refractive error10.6
25age-related macular degeneration 810.6
26macular dystrophy10.6
27complement factor h deficiency10.5CFH
28retinitis pigmentosa10.5
29vitelliform macular dystrophy10.5
31late-onset retinal degeneration10.5
32age-related macular degeneration 210.5
33age-related macular degeneration 310.5
34age-related macular degeneration 410.5
35age-related macular degeneration 510.5
36age-related macular degeneration 610.5
37age-related macular degeneration 710.5
38age-related macular degeneration 910.5
39juvenile macular degeneration and hypotrichosis10.5
40complement deficiency10.5C3
41progressive supranuclear palsy10.5APOE
42cone-rod dystrophy 210.4ABCA4, TIMP3
43alzheimer's disease10.4
45vitreous detachment10.4
46cutis laxa10.4
48retinal disease10.4
50retinal degeneration with nanophthalmos, cystic macular degeneration, and angle closure glaucoma10.4

Graphical network of the top 20 diseases related to Age Related Macular Degeneration:

Diseases related to age related macular degeneration

Symptoms for Age Related Macular Degeneration

About this section

Clinical features from OMIM:

613761, 608895, 610149, 153800, 610698, 613757, 613778, 613784, 611953, 611378 611488, 603075 more

Drugs & Therapeutics for Age Related Macular Degeneration

About this section

Drug clinical trials:

Search ClinicalTrials for Age Related Macular Degeneration

Search NIH Clinical Center for Age Related Macular Degeneration

Inferred drug relations via UMLS61/NDF-RT40:

Cell-based therapeutics:

LifeMap Discovery
The database of embryonic development, stem cell research and regenerative medicine
Read about Age Related Macular Degeneration cell therapies at LifeMap Discovery.

Genetic Tests for Age Related Macular Degeneration

About this section

Genetic tests related to Age Related Macular Degeneration:

id Genetic test Affiliating Genes
1 Age-Related Macular Degeneration21 23 ABCA4, ARMS2, C2, C3, CFB, CFH, ERCC6, FBLN5, HMCN1, HTRA1 (show all 12)


Anatomical Context for Age Related Macular Degeneration

About this section

MalaCards organs/tissues related to Age Related Macular Degeneration:

Eye, Retina, Endothelial, Bone, Testes, T cells, Brain, Kidney, Liver, Skin, Monocytes

LifeMap Discovery
The database of embryonic development, stem cell research and regenerative medicine

Cells/anatomical compartments in embryo or adult related to Age Related Macular Degeneration:
id TissueAnatomical CompartmentCell Relevance
1 EyeOuter Nuclear LayerMature L Cone Cells Potential therapeutic candidate, affected by disease
2 EyeOuter Nuclear LayerMature M Cone Cells Potential therapeutic candidate, affected by disease
3 EyeRetinal Pigmented EpitheliumMature Retinal Pigmented Epithelium Cells Potential therapeutic candidate, affected by disease
4 EyeOuter Nuclear LayerMature Rod Cells Potential therapeutic candidate, affected by disease
5 EyeOuter Nuclear LayerMature S Cone Cells Potential therapeutic candidate, affected by disease
6 EyeRetinal Pigmented EpitheliumRetinal Pigmented Epithelium Progenitor Cells Potential therapeutic candidate

Animal Models for Age Related Macular Degeneration or affiliated genes

About this section

Publications for Age Related Macular Degeneration

About this section

Articles related to Age Related Macular Degeneration:

(show top 50)    (show all 1177)
Differential Vulnerability of Retinal Layers to Early Age-Related Macular Degeneration: Evidence by SD-OCT Segmentation Analysis. (24408984)
Anterior Chamber Paracentesis Might Prevent Sustained Intraocular Pressure Elevation after Intravitreal Injections of Ranibizumab for Age-Related Macular Degeneration. (25401265)
Nutrients related to the incidence of early and late age-related macular degeneration. (24056822)
Serum and macular responses to multiple xanthophyll supplements in patients with early age-related macular degeneration. (23312760)
Genetic Susceptibility, Dietary Antioxidants, and Long-term Incidence of Age-related Macular Degeneration in Two Populations. (24290803)
Influence of TIMP3/SYN3 polymorphisms on the phenotypic presentation of age-related macular degeneration. (23422939)
PIGMENT EPITHELIAL TEARS ASSOCIATED WITH ANTI-VEGF THERAPY: Incidence, Long-term Visual Outcome, and Relationship with Pigment Epithelial Detachment in Age-related Macular Degeneration. (24296398)
Visual performance in patients with neovascular age-related macular degeneration undergoing treatment with intravitreal ranibizumab. (23533703)
Elevated norepinephrine may be an etiological factor in a wide range of diseases: age-related macular degeneration, systemic lupus erythematosus, atrial fibrillation, metabolic syndrome. (23410497)
Vascular disrupting agent for neovascular age related macular degeneration: a pilot study of the safety and efficacy of intravenous combretastatin A-4 phosphate. (23316779)
Costs of newly diagnosed neovascular age-related macular degeneration among medicare beneficiaries, 2004-2008. (23296047)
Coding variants in ARMS2 and the risk of age-related macular degeneration. (23572227)
Macular xanthophylls and I8-3 long-chain polyunsaturated fatty acids in age-related macular degeneration: a randomized trial. (23519529)
Genetic influences on the outcome of anti-vascular endothelial growth factor treatment in neovascular age-related macular degeneration. (23582991)
Comparative effectiveness of aflibercept for the treatment of patients with neovascular age-related macular degeneration. (23503202)
Long-term blood pressure and age-related macular degeneration: the ALIENOR study. (23404120)
Diabetes, diabetic retinopathy, and age-related macular degeneration: an unexpected relationship. (23470781)
Age-related macular degeneration and association of CFH Y402H and LOC387715 A69S polymorphisms in a Turkish population. (21790300)
Genome-wide association study of age-related macular degeneration identifies associated variants in the TNXB-FKBPL-NOTCH4 region of chromosome 6p21.3. (22694956)
Single nucleotide polymorphisms in MCP-1 and its receptor are associated with the risk of age related macular degeneration. (23185481)
Patient awareness of binocular central scotoma in age-related macular degeneration. (22863789)
Local vs. systemic mononuclear phagocytes in age-related macular degeneration and their regulation by CCL2-CCR2 and CX3CL1-CX3CR1 chemokine signalling. (22183310)
Complement factor H Y402H variant and risk of age-related macular degeneration in Asians: a systematic review and meta-analysis. (20869121)
DICER1 deficit induces Alu RNA toxicity in age-related macular degeneration. (21297615)
Charles Bonnet syndrome improves when treatment is effective in age-related macular degeneration. (20733019)
CFH and ARMS2 variations in age-related macular degeneration, polypoidal choroidal vasculopathy, and retinal angiomatous proliferation. (20574013)
Impaired binding of the age-related macular degeneration-associated complement factor H 402H allotype to Bruch's membrane in human retina. (20660596)
Noncoding variant in the complement factor H gene and risk of exudative age-related macular degeneration in a Chinese population. (19850835)
Detecting Genes and Gene-gene Interactions for Age-related Macular Degeneration with a Forest-based Approach. (20161521)
A phase I study of intravitreal vascular endothelial growth factor trap-eye in patients with neovascular age-related macular degeneration. (19700196)
Meta-analysis of the association of the HTRA1 polymorphisms with the risk of age-related macular degeneration. (19026638)
Description of the Age-Related Eye Disease Study 9-step severity scale applied to participants in the Complications of Age-related Macular Degeneration Prevention Trial. (19752423)
Genotype-phenotype correlations for exudative age-related macular degeneration associated with homozygous HTRA1 and CFH genotypes. (18362109)
Pegaptanib sodium for neovascular age-related macular degeneration: clinical experience in the UK. (19668726)
HTRA1 variants in exudative age-related macular degeneration and interactions with smoking and CFH. (18316707)
Variants in the 10q26 gene cluster (LOC387715 and HTRA1) exhibit enhanced risk of age-related macular degeneration along with CFH in Indian patients. (18436811)
Age-related macular degeneration is associated with the HLA-Cw*0701 Genotype and the natural killer cell receptor AA haplotype. (18515573)
Association between dietary glycemic index and age-related macular degeneration in nondiabetic participants in the Age-Related Eye Disease Study. (17616779)
Progress in defining the molecular biology of age related macular degeneration. (17659362)
Molecular mechanism of choroidal neovascularization in age-related macular degeneration]. (18051818)
A tag-single nucleotide polymorphisms approach to the vascular endothelial growth factor-A gene in age-related macular degeneration. (18079689)
Pegaptanib in the treatment of wet, age-related macular degeneration. (17717967)
Genetic aspects of age-related macular degeneration. (15947798)
Treatment of neovascular age-related macular degeneration with Ranibizumab/Lucentis]. (15973626)
Joint effects of smoking history and APOE genotypes in age-related macular degeneration. (16288198)
CST3 genotype associated with exudative age related macular degeneration. (11815350)
Allelic variation in the VMD2 gene in best disease and age-related macular degeneration. (10798642)
ABCR gene analysis in familial exudative age-related macular degeneration. (10634626)
Oxidative damage and age-related macular degeneration. (10562656)
Exclusion of TIMP3 as a candidate locus in age-related macular degeneration. (9152225)

Variations for Age Related Macular Degeneration

About this section

UniProtKB/Swiss-Prot genetic disease variations for Age Related Macular Degeneration:

id Symbol AA change Variation ID SNP ID

Expression for genes affiliated with Age Related Macular Degeneration

About this section
2BioGPS, 16Gene Expression Omnibus DataSets, 31LifeMap Discovery®
See all sources
LifeMap Discovery
Genes differentially expressed in tissues of Age Related Macular Degeneration patients vs. healthy controls: 31 (show all 304)
id Gene Description Tissue Up/Dn Fold Change (log2) P value
1CRYAAcrystallin, alpha AEye+2.680.000
2ATP6V1C2ATPase, H+ transporting, lysosomal 42kDa, V1 subunit C2Eye+2.460.000
3ODAModontogenic, ameloblast asssociatedEye+2.430.000
4IL6interleukin 6 (interferon, beta 2)Eye+2.430.000
5DEFA3defensin, alpha 3, neutrophil-specificEye-2.380.000
6ADAMTS5ADAM metallopeptidase with thrombospondin type 1 motif, 5Eye+2.300.000
7CXCL9chemokine (C-X-C motif) ligand 9Eye+2.260.000
8DAPL1death associated protein-like 1Eye+2.230.000
10IL1Binterleukin 1, betaEye+2.110.000
11IBSPintegrin-binding sialoproteinEye+2.030.000
12PDK4pyruvate dehydrogenase kinase, isozyme 4Eye+2.000.000
13C20orf26chromosome 20 open reading frame 26Eye-1.980.000
14CHI3L2chitinase 3-like 2Eye-1.970.000
15CTSVcathepsin VEye+1.930.000
16BPIFB4BPI fold containing family B, member 4Eye+1.930.000
17COMPcartilage oligomeric matrix proteinEye+1.920.000
18FNDC1fibronectin type III domain containing 1Eye+1.890.000
19WIF1WNT inhibitory factor 1Eye+1.890.000
20FDCSPfollicular dendritic cell secreted proteinEye+1.860.000
21CXCL10chemokine (C-X-C motif) ligand 10Eye+1.840.000
22CXCL1chemokine (C-X-C motif) ligand 1 (melanoma growth stimulating activity, alpha)Eye+1.830.000
23CCL8chemokine (C-C motif) ligand 8Eye+1.810.000
24RAXretina and anterior neural fold homeoboxEye+1.790.000
25WFIKKN2WAP, follistatin/kazal, immunoglobulin, kunitz and netrin domain containing 2Eye+1.780.000
26GPR88G protein-coupled receptor 88Eye+1.770.000
27MGARPmitochondria-localized glutamic acid-rich proteinEye+1.760.000
28LOC100289290Ig heavy chain V-III region VH26-likeEye+1.720.000
29THBS2thrombospondin 2Eye+1.720.000
30ANO1anoctamin 1, calcium activated chloride channelEye+1.720.000
31STEAP4STEAP family member 4Eye+1.710.000
32HILPDAhypoxia inducible lipid droplet-associatedEye+1.710.000
33SLC2A5solute carrier family 2 (facilitated glucose/fructose transporter), member 5Eye+1.710.000
34LRRC15leucine rich repeat containing 15Eye+1.710.000
35GFAPglial fibrillary acidic proteinEye+1.700.000
36SELEselectin EEye-1.700.000
38CD24CD24 moleculeEye+1.680.000
39HLA-DQA2major histocompatibility complex, class II, DQ alpha 2Eye+1.680.000
40PLA2G7phospholipase A2, group VII (platelet-activating factor acetylhydrolase, plasma)Eye-1.670.000
41CSF3colony stimulating factor 3 (granulocyte)Eye+1.660.000
42SPON1spondin 1, extracellular matrix proteinEye+1.630.000
43SLC1A3solute carrier family 1 (glial high affinity glutamate transporter), member 3Eye+1.620.000
44ANGPT2angiopoietin 2Eye+1.570.000
45CXCL2chemokine (C-X-C motif) ligand 2Eye+1.570.000
46SLAMF1signaling lymphocytic activation molecule family member 1Eye+1.550.000
47CTHRC1collagen triple helix repeat containing 1Eye+1.550.000
48CA12carbonic anhydrase XIIEye+1.540.000
49GRPgastrin-releasing peptideEye+1.540.000
50FAM84Afamily with sequence similarity 84, member AEye+1.540.000
51CCL2chemokine (C-C motif) ligand 2Eye+1.520.000
52TMSB15Athymosin beta 15aEye+1.520.000
54MARCOmacrophage receptor with collagenous structureEye+1.510.000
55BIRC5baculoviral IAP repeat containing 5Eye+1.500.000
56CD8ACD8a moleculeEye-1.500.000
57LRATlecithin retinol acyltransferase (phosphatidylcholine--retinol O-acyltransferase)Eye-1.490.000
58KRT15keratin 15Eye+1.480.000
59CEMIPcell migration inducing protein, hyaluronan bindingEye-1.480.000
60UBDubiquitin DEye+1.480.000
61TBX1T-box 1Eye+1.470.000
62CRLF1cytokine receptor-like factor 1Eye+1.470.000
63SNX10sorting nexin 10Eye+1.470.000
64FAM26Ffamily with sequence similarity 26, member FEye+1.470.000
65SOCS1suppressor of cytokine signaling 1Eye+1.470.000
66INHBBinhibin, beta BEye+1.460.000
67CRYBB2crystallin, beta B2Eye+1.460.000
68CCL14chemokine (C-C motif) ligand 14Eye+1.460.000
69VCAM1vascular cell adhesion molecule 1Eye+1.450.000
70CHRDL2chordin-like 2Eye+1.450.000
71CXCL11chemokine (C-X-C motif) ligand 11Eye+1.440.000
72DEFA4defensin, alpha 4, corticostatinEye-1.440.000
73KLRC1killer cell lectin-like receptor subfamily C, member 1Eye+1.430.000
74CD38CD38 moleculeEye+1.430.000
75GBP5guanylate binding protein 5Eye+1.420.000
76S100A2S100 calcium binding protein A2Eye+1.420.000
77MMP9matrix metallopeptidase 9 (gelatinase B, 92kDa gelatinase, 92kDa type IV collagenase)Eye+1.420.000
78ARL9ADP-ribosylation factor-like 9Eye+1.410.000
80FCGR1BFc fragment of IgG, high affinity Ib, receptor (CD64)Eye+1.410.000
81OSMoncostatin MEye+1.400.000
82ANGPTL4angiopoietin-like 4Eye+1.400.000
83CLEC4EC-type lectin domain family 4, member EEye+1.390.000
84LRRC2leucine rich repeat containing 2Eye+1.380.000
85RGS1regulator of G-protein signaling 1Eye+1.380.000
86FAM150Bfamily with sequence similarity 150, member BEye+1.380.000
87DKK3dickkopf WNT signaling pathway inhibitor 3Eye+1.380.000
88CRHBPcorticotropin releasing hormone binding proteinEye-1.370.000
90ERAP2endoplasmic reticulum aminopeptidase 2Eye+1.360.000
92PMP2peripheral myelin protein 2Eye+1.360.000
93KCNE1potassium voltage-gated channel, Isk-related family, member 1Eye+1.360.000
94CCL4chemokine (C-C motif) ligand 4Eye+1.350.000
95LY6Klymphocyte antigen 6 complex, locus KEye-1.350.000
96APOLD1apolipoprotein L domain containing 1Eye+1.350.000
97GZMHgranzyme H (cathepsin G-like 2, protein h-CCPX)Eye+1.350.000
99PRSS33protease, serine, 33Eye+1.340.000
100TMEM155transmembrane protein 155Eye+1.340.000
101RBM3RNA binding motif (RNP1, RRM) protein 3Eye+1.340.000
102GALgalanin/GMAP prepropeptideEye-1.340.000
103SLC16A12solute carrier family 16, member 12Eye+1.340.000
104IL4I1interleukin 4 induced 1Eye+1.340.000
105NPR3natriuretic peptide receptor 3Eye-1.340.000
106IDO1indoleamine 2,3-dioxygenase 1Eye+1.330.000
107FOLR1folate receptor 1 (adult)Eye+1.330.000
108KIF25kinesin family member 25Eye-1.330.000
109CNTNAP2contactin associated protein-like 2Eye+1.330.000
110CCR2chemokine (C-C motif) receptor 2Eye+1.320.000
111ANKRD22ankyrin repeat domain 22Eye+1.320.000
112G0S2G0/G1switch 2Eye-1.320.000
113IL1R2interleukin 1 receptor, type IIEye+1.320.000
114SLCO1B3solute carrier organic anion transporter family, member 1B3Eye-1.310.000
115HHATLhedgehog acyltransferase-likeEye-1.310.000
116LOC344887NmrA-like family domain containing 1 pseudogeneEye-1.310.000
117CLMPCXADR-like membrane proteinEye-1.300.000
118IGJimmunoglobulin J polypeptide, linker protein for immunoglobulin alpha and mu polypeptidesEye+1.300.000
119CD48CD48 moleculeEye+1.300.000
121SLAMF7SLAM family member 7Eye+1.290.000
123KCNN4potassium intermediate/small conductance calcium-activated channel, subfamily N, member 4Eye-1.280.000
124MYRIPmyosin VIIA and Rab interacting proteinEye+1.280.000
125APOC1apolipoprotein C-IEye+1.280.000
126FCGBPFc fragment of IgG binding proteinEye-1.280.000
127GAS1growth arrest-specific 1Eye-1.270.000
128TNFAIP3tumor necrosis factor, alpha-induced protein 3Eye+1.270.000
129PTPN3protein tyrosine phosphatase, non-receptor type 3Eye-1.270.000
130SLC38A1solute carrier family 38, member 1Eye+1.260.000
131C1orf186chromosome 1 open reading frame 186Eye+1.260.000
132PTGS2prostaglandin-endoperoxide synthase 2 (prostaglandin G/H synthase and cyclooxygenase)Eye+1.260.000
134FAM208Bfamily with sequence similarity 208, member BEye+1.250.000
135FCRL5Fc receptor-like 5Eye+1.250.000
136EGFL6EGF-like-domain, multiple 6Eye+1.250.000
137MRC1mannose receptor, C type 1Eye+1.250.000
138P2RY14purinergic receptor P2Y, G-protein coupled, 14Eye+1.250.000
139RPSAribosomal protein SAEye+1.240.000
140PNMTphenylethanolamine N-methyltransferaseEye+1.240.000
141SLPIsecretory leukocyte peptidase inhibitorEye-1.240.000
142CCL17chemokine (C-C motif) ligand 17Eye+1.240.000
143SLCO1C1solute carrier organic anion transporter family, member 1C1Eye-1.230.000
144SLC22A6solute carrier family 22 (organic anion transporter), member 6Eye-1.230.000
145SLC14A1solute carrier family 14 (urea transporter), member 1 (Kidd blood group)Eye-1.230.000
146HIST1H2AChistone cluster 1, H2acEye-1.230.000
147CYTL1cytokine-like 1Eye+1.230.000
148ZDHHC11zinc finger, DHHC-type containing 11Eye-1.230.000
149CDH18cadherin 18, type 2Eye+1.220.000
150TGFB2transforming growth factor, beta 2Eye+1.220.000
151PLAC4placenta-specific 4Eye-1.220.000
152HSPA1Aheat shock 70kDa protein 1AEye-1.220.000
153LRP8low density lipoprotein receptor-related protein 8, apolipoprotein e receptorEye-1.210.000
154HBDhemoglobin, deltaEye-1.210.000
155SULT1B1sulfotransferase family, cytosolic, 1B, member 1Eye+1.210.000
156PTGISprostaglandin I2 (prostacyclin) synthaseEye-1.210.000
157PLXNA4plexin A4Eye-1.210.000
158TRPM3transient receptor potential cation channel, subfamily M, member 3Eye-1.210.000
159FAM74A3family with sequence similarity 74, member A3Eye-1.200.000
160BCL2A1BCL2-related protein A1Eye+1.200.000
161SFRP2secreted frizzled-related protein 2Eye+1.200.000
162TNFRSF11Btumor necrosis factor receptor superfamily, member 11bEye+1.200.000
163H19H19, imprinted maternally expressed transcript (non-protein coding)Eye+1.200.000
164TDO2tryptophan 2,3-dioxygenaseEye-1.200.000
165APOL6apolipoprotein L, 6Eye+1.200.000
166PCK1phosphoenolpyruvate carboxykinase 1 (soluble)Eye+1.200.000
167NABP1nucleic acid binding protein 1Eye+1.200.000
168C7orf31chromosome 7 open reading frame 31Eye+1.200.000
169CDKN2Acyclin-dependent kinase inhibitor 2AEye+1.190.000
170IL1RL1interleukin 1 receptor-like 1Eye+1.190.000
171POM121L8PPOM121 transmembrane nucleoporin-like 8 pseudogeneEye+1.190.000
172GBP1guanylate binding protein 1, interferon-inducibleEye+1.190.000
173KCTD4potassium channel tetramerization domain containing 4Eye+1.180.000
174FAM151Afamily with sequence similarity 151, member AEye+1.180.000
175CYP26A1cytochrome P450, family 26, subfamily A, polypeptide 1Eye-1.180.000
177WDR27WD repeat domain 27Eye-1.180.000
178LINC00314long intergenic non-protein coding RNA 314Eye+1.170.000
179SDCBPsyndecan binding protein (syntenin)Eye-1.170.000
180HK2hexokinase 2Eye+1.170.000
182WFDC2WAP four-disulfide core domain 2Eye+1.170.000
183KLRC4killer cell lectin-like receptor subfamily C, member 4Eye+1.170.000
184CX3CR1chemokine (C-X3-C motif) receptor 1Eye+1.160.000
185FGF9fibroblast growth factor 9Eye+1.160.000
186HBA2hemoglobin, alpha 2Eye+1.160.000
187MSX2msh homeobox 2Eye+1.160.000
188ADAMTS1ADAM metallopeptidase with thrombospondin type 1 motif, 1Eye+1.160.000
189KMT2Clysine (K)-specific methyltransferase 2CEye-1.160.000
190ACE2angiotensin I converting enzyme 2Eye+1.160.000
191TNFAIP6tumor necrosis factor, alpha-induced protein 6Eye+1.160.000
192IGFBP3insulin-like growth factor binding protein 3Eye+1.160.000
193MAGED4Bmelanoma antigen family D, 4BEye-1.160.000
194NHLRC3NHL repeat containing 3Eye-1.150.000
195TMEM26transmembrane protein 26Eye-1.150.000
196CEACAM8carcinoembryonic antigen-related cell adhesion molecule 8Eye-1.150.000
197NOSTRINnitric oxide synthase traffickingEye+1.150.000
198HBBhemoglobin, betaEye+1.150.000
199ABCG2ATP-binding cassette, sub-family G (WHITE), member 2Eye+1.150.000
200ADAD2adenosine deaminase domain containing 2Eye-1.140.000
202HMGCS23-hydroxy-3-methylglutaryl-CoA synthase 2 (mitochondrial)Eye-1.140.000
203ZC3H12Azinc finger CCCH-type containing 12AEye+1.140.000
204C2CD4BC2 calcium-dependent domain containing 4BEye+1.140.000
206KLK11kallikrein-related peptidase 11Eye+1.130.000
207SCGB1D2secretoglobin, family 1D, member 2Eye+1.130.000
208CD69CD69 moleculeEye+1.130.000
209SMOC1SPARC related modular calcium binding 1Eye-1.120.000
210FGGfibrinogen gamma chainEye-1.120.000
211SLAMF8SLAM family member 8Eye+1.120.000
212DFNB59deafness, autosomal recessive 59Eye-1.120.000
213FCRL2Fc receptor-like 2Eye+1.120.000
214FZD10frizzled class receptor 10Eye+1.120.000
215KRT86keratin 86Eye+1.120.000
216ZG16Bzymogen granule protein 16BEye+1.110.000
217ACTC1actin, alpha, cardiac muscle 1Eye+1.110.000
218HLA-DQA1major histocompatibility complex, class II, DQ alpha 1Eye+1.110.000
219SCGB1D1secretoglobin, family 1D, member 1Eye+1.110.000
220ADRA2Aadrenoceptor alpha 2AEye+1.110.000
221CPLX3complexin 3Eye+1.110.000
222CCL23chemokine (C-C motif) ligand 23Eye+1.110.000
223SLC7A4solute carrier family 7, member 4Eye-1.100.000
224GZMBgranzyme B (granzyme 2, cytotoxic T-lymphocyte-associated serine esterase 1)Eye+1.100.000
225SCGB3A1secretoglobin, family 3A, member 1Eye+1.100.000
226LHX6LIM homeobox 6Eye-1.100.000
227TNFAIP2tumor necrosis factor, alpha-induced protein 2Eye+1.100.000
228GPR126G protein-coupled receptor 126Eye+1.100.000
229TK1thymidine kinase 1, solubleEye+1.100.000
230COL25A1collagen, type XXV, alpha 1Eye+1.100.000
231IKZF1IKAROS family zinc finger 1 (Ikaros)Eye-1.100.000
232COL12A1collagen, type XII, alpha 1Eye+1.100.000
233PDE6Hphosphodiesterase 6H, cGMP-specific, cone, gammaEye-1.100.000
234PAPSS23'-phosphoadenosine 5'-phosphosulfate synthase 2Eye+1.090.000
235FAM161Afamily with sequence similarity 161, member AEye+1.090.000
236SCDstearoyl-CoA desaturase (delta-9-desaturase)Eye+1.090.000
237OMGoligodendrocyte myelin glycoproteinEye+1.090.000
238AKR1C3aldo-keto reductase family 1, member C3Eye+1.090.000
239SALL4spalt-like transcription factor 4Eye-1.090.000
240KLRC2killer cell lectin-like receptor subfamily C, member 2Eye+1.090.000
241LIMS3-LOC440895LIMS3-LOC440895 readthroughEye+1.090.000
242DIO3deiodinase, iodothyronine, type IIIEye+1.090.000
243NRXN3neurexin 3Eye-1.090.000
244ORM1orosomucoid 1Eye-1.090.000
245BNC2basonuclin 2Eye-1.090.000
246CKMT2creatine kinase, mitochondrial 2 (sarcomeric)Eye+1.090.000
247FMO3flavin containing monooxygenase 3Eye+1.090.000
248COLEC11collectin sub-family member 11Eye+1.090.000
249METTL21Amethyltransferase like 21AEye+1.090.000
250ARMC9armadillo repeat containing 9Eye-1.090.000
251AKR1B10aldo-keto reductase family 1, member B10 (aldose reductase)Eye-1.080.000
252HSD17B1hydroxysteroid (17-beta) dehydrogenase 1Eye-1.080.000
253LOC100272216uncharacterized LOC100272216Eye-1.080.000
254BTNL9butyrophilin-like 9Eye+1.080.000
255NEFLneurofilament, light polypeptideEye-1.080.000
257H2AFJH2A histone family, member JEye-1.080.000
258GSTT2glutathione S-transferase theta 2Eye+1.080.000
259TREM2triggering receptor expressed on myeloid cells 2Eye+1.080.000
260EDNRAendothelin receptor type AEye-1.080.000
261EDN1endothelin 1Eye+1.080.000
262CYP4Z1cytochrome P450, family 4, subfamily Z, polypeptide 1Eye-1.080.000
263APC2adenomatosis polyposis coli 2Eye+1.080.000
264FLJ44087uncharacterized LOC101927980Eye-1.080.000
265FBXO40F-box protein 40Eye-1.070.000
266CNTN3contactin 3 (plasmacytoma associated)Eye-1.070.000
267SOSTDC1sclerostin domain containing 1Eye+1.070.000
269TMEM27transmembrane protein 27Eye+1.070.000
270LAMP5lysosomal-associated membrane protein family, member 5Eye+1.070.000
272HAUS5HAUS augmin-like complex, subunit 5Eye-1.060.000
273SLCO1A2solute carrier organic anion transporter family, member 1A2Eye+1.060.000
274C1QTNF1C1q and tumor necrosis factor related protein 1Eye+1.060.000
275ALDH1A3aldehyde dehydrogenase 1 family, member A3Eye+1.060.000
276CYP4B1cytochrome P450, family 4, subfamily B, polypeptide 1Eye+1.060.000
277SLC5A10solute carrier family 5 (sodium/sugar cotransporter), member 10Eye+1.050.000
278EFCAB1EF-hand calcium binding domain 1Eye-1.050.000
279SIGLEC11sialic acid binding Ig-like lectin 11Eye-1.050.000
280PKDCCprotein kinase domain containing, cytoplasmicEye-1.050.000
281MEDAGmesenteric estrogen-dependent adipogenesisEye-1.050.000
282KIZkizuna centrosomal proteinEye-1.050.000
283BCMO1beta-carotene 15,15'-monooxygenase 1Eye-1.040.000
284IGLL1immunoglobulin lambda-like polypeptide 1Eye-1.040.000
285NMRK2nicotinamide riboside kinase 2Eye-1.040.000
286GABRQgamma-aminobutyric acid (GABA) A receptor, thetaEye-1.040.000
287BCAS4breast carcinoma amplified sequence 4Eye-1.040.000
288MMP3matrix metallopeptidase 3 (stromelysin 1, progelatinase)Eye-1.030.000
289KCNK17potassium channel, subfamily K, member 17Eye-1.030.000
290OLFM4olfactomedin 4Eye-1.030.000
291HTRA4HtrA serine peptidase 4Eye-1.030.000
292GUSBP3glucuronidase, beta pseudogene 3Eye-1.030.000
293NLRP12NLR family, pyrin domain containing 12Eye-1.030.000
294VASH2vasohibin 2Eye-1.020.000
297SPAG8sperm associated antigen 8Eye-1.010.000
298YKT6YKT6 v-SNARE homolog (S. cerevisiae)Eye-1.010.000
299MARCH2membrane-associated ring finger (C3HC4) 2, E3 ubiquitin protein ligaseEye-1.010.000
300OPHN1oligophrenin 1Eye-1.010.000
301NCS1neuronal calcium sensor 1Eye-1.010.000
302FAM118Afamily with sequence similarity 118, member AEye-1.010.000
303LOXlysyl oxidaseEye-1.000.000
304CXCL12chemokine (C-X-C motif) ligand 12Eye-1.000.000

Expression patterns in normal tissues for genes affiliated with Age Related Macular Degeneration

Search GEO for disease gene expression data for Age Related Macular Degeneration.

Pathways for genes affiliated with Age Related Macular Degeneration

About this section

Pathways related to Age Related Macular Degeneration according to GeneCards/GeneDecks:

idSuper pathways (with members indented)ScoreTop Affiliating Genes
110.1CX3CR1, APOE
Show member pathways
Show member pathways
Complement Activation, Classical Pathway37
Complement and Coagulation Cascades37
9.8CFH, CFB, C2, C3
49.8CFH, CFB, C2, C3
Show member pathways
Immune response Alternative complement pathway59
Immune response Lectin Induced complement pathway59
Immune response Classic complement pathway59
9.6C3, C2, CFHR3, CFB, CFH
Show member pathways
9.6CFH, CFB, CFHR3, C2, C3

Compounds for genes affiliated with Age Related Macular Degeneration

About this section
44Novoseek, 25HMDB, 12DrugBank, 29IUPHAR
See all sources

Compounds related to Age Related Macular Degeneration according to GeneCards/GeneDecks:

idCompoundScoreTop Affiliating Genes
1agarose449.9CFB, TIMP3, C3
2hyaluronic acid44 2510.9APOE, VEGFA, CFH
3h2o2449.8ERCC6, PLEKHA1, HTRA1, APOE
4vitamin a44 25 1211.7ABCA4, APOE, C3
5vegf449.5CX3CR1, TIMP3, APOE, VEGFA, FBLN5
6serine449.4CFH, CFB, C2, APOE, HTRA1, C3
7lipid449.4ABCA4, APOE, TIMP3, MT-ND2, PLEKHA1, C3
8heparin44 29 25 1212.3C3, TIMP3, APOE, VEGFA, CFHR1, CFH

GO Terms for genes affiliated with Age Related Macular Degeneration

About this section

Cellular components related to Age Related Macular Degeneration according to GeneCards/GeneDecks:

idNameGO IDScoreTop Affiliating Genes
1extracellular matrixGO:0310129.5FBLN5, TIMP3, HTRA1, HMCN1
2blood microparticleGO:0725629.4C3, CFH, CFB, CFHR3, CFHR1, APOE
3extracellular regionGO:0055769.2C3, APOE, C2, VEGFA, FBLN5, CFB
4extracellular spaceGO:0056158.7CFH, CFHR3, CFHR1, FBLN5, VEGFA, C2

Biological processes related to Age Related Macular Degeneration according to GeneCards/GeneDecks:

(show all 8)
idNameGO IDScoreTop Affiliating Genes
1photoreceptor cell maintenanceGO:04549410.1ERCC6, ABCA4
2complement activation, alternative pathwayGO:00695710.1C3, CFB, CFH
3regulation of complement activationGO:03044910.0CFH, CFB, C2, C3
4complement activationGO:0069569.7C3, C2, CFHR1, CFB, CFH
5artery morphogenesisGO:0488449.7APOE, VEGFA
6visual perceptionGO:0076019.7ABCA4, TIMP3, RAX2, HMCN1
7positive regulation of angiogenesisGO:0457669.7C3, CX3CR1, VEGFA
8G-protein coupled receptor signaling pathwayGO:0071869.6GPR75, APOE, CX3CR1, C3

Molecular functions related to Age Related Macular Degeneration according to GeneCards/GeneDecks:

idNameGO IDScoreTop Affiliating Genes
1serine-type endopeptidase activityGO:00425210.0HTRA1, C2, CFB
2heparin bindingGO:0082019.6APOE, VEGFA, CFH

Products for genes affiliated with Age Related Macular Degeneration

About this section
  • Antibodies
  • Proteins
  • Lysates
  • Antibodies
  • Proteins
  • Kits and Assays

Sources for Age Related Macular Degeneration

About this section
27ICD10 via Orphanet
35MESH via Orphanet
47OMIM via Orphanet
57SNOMED-CT via Orphanet
62UMLS via Orphanet