MCID: AGG001
MIFTS: 47

Aggressive Periodontitis malady

Oral diseases category
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Summaries for Aggressive Periodontitis

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8Disease Ontology, 65Wikipedia, 47OMIM, 33MalaCards
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Disease Ontology:8 A periodontitis that is characterized by rapid attachment loss and bone destruction in the presence of little local factors such as dental plaque and dental calculus resulting in inflammation and a loss of periodontium.

MalaCards: Aggressive Periodontitis, also known as periodontitis, juvenile, is related to periodontitis and gingivitis. An important gene associated with Aggressive Periodontitis is FCGR3B (Fc fragment of IgG, low affinity IIIb, receptor (CD16b)), and among its related pathways are Fc-GammaR Pathway and Tuberculosis. The compounds tositumomab and ibritumomab have been mentioned in the context of this disorder. Affiliated tissues include bone, monocytes and whole blood, and related mouse phenotypes are hematopoietic system and immune system.

Wikipedia:65 Aggressive periodontitis describes a type of periodontal disease and includes two of the seven... more...

Description from OMIM:47 170650,608526

Aliases & Classifications for Aggressive Periodontitis

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8Disease Ontology, 10DISEASES, 45Novoseek, 62UMLS, 58SNOMED-CT, 47OMIM, 35MeSH
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Classifications:

Malacards categories (disease lists): (See all malacards categories)
Anatomical: Oral diseases


Aliases & Descriptions:

aggressive periodontitis 8 10 62
periodontitis, juvenile 62
periodontitis juvenile 45
juvenile periodontitis 8


External Ids:

Disease Ontology8 DOID:1474
SNOMED-CT58 2624008, 49965002
MeSH35 D010520

Related Diseases for Aggressive Periodontitis

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17GeneCards, 18GeneDecks
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Diseases in the Aggressive Periodontitis family:

Periodontitis, Aggressive, 2

Diseases related to Aggressive Periodontitis via text searches within MalaCards or GeneCards/GeneDecks gene sharing:

(show all 40)
idRelated DiseaseScoreTop Affiliating Genes
1periodontitis32.1IL1A, MMP8, DEFB1
2gingivitis31.3IL1A, MMP8
3periodontal disease30.7DEFB1, MMP8, IL1A
4arthritis30.5FCGR2A, FCGR3B, MMP8, IL1A
5rheumatoid arthritis30.4FCGR2A, FCGR3B, MMP8, IL1A
6sarcoidosis30.1IL1A, DEFB1
7periodontosis10.7
8fibromatosis10.4
9type 1 diabetes mellitus10.3
10diabetes mellitus10.3
11periodontitis 1, juvenile10.2
12blindness10.2
13tonsillitis10.1IL1A
14malaria10.1FCGR2A
15periapical granuloma10.1MMP8
16amelogenesis imperfecta10.1
17rickets10.1
18cutaneous lupus erythematosus10.1
19fanconi's anemia10.1
20dental caries10.1
21intellectual disability10.1
22lupus erythematosus10.1
23ectodermal dysplasia10.1
24dentinogenesis imperfecta10.0
25tooth agenesis10.0
26pierre robin sequence10.0
27pustulosis palmaris et plantaris10.0
28neutropenia10.0FPR1, FCGR3B
29peritonitis10.0MMP8, FCGR3B
30nephritis10.0FCGR2A, FCGR3B
31systemic lupus erythematosus10.0FCGR3B, FCGR2A
32synovitis10.0IL1A, MMP8
33cholesteatoma10.0IL1A, MMP8, DEFB1
34hypersensitivity reaction type ii disease10.0FCGR2A, FCGR3B, IL1A
35osteoarthritis10.0FCGR3B, MMP8, IL1A
36leukemia10.0FPR1, IL1A, FCGR3B, CYBA
37ipex syndrome10.0FPR1, MMP8, FCGR3B, FCGR2A
38sepsis10.0DEFB1, FCGR2A, FCGR3B, IL1A, FPR1
39atherosclerosis9.9CYBA, FCGR2A, MMP8, IL1A
40asthma9.9DEFB1, FCGR3B, FCER1A, MMP8

Graphical network of the top 20 diseases related to Aggressive Periodontitis:



Diseases related to aggressive periodontitis

Symptoms for Aggressive Periodontitis

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47OMIM
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Clinical features from OMIM:

170650,608526

Drugs & Therapeutics for Aggressive Periodontitis

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Sources:
42NIH Clinical Center, 6ClinicalTrials, 62UMLS, 41NDF-RT
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Drug clinical trials:

Search ClinicalTrials for Aggressive Periodontitis

Search NIH Clinical Center for Aggressive Periodontitis

Genetic Tests for Aggressive Periodontitis

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Anatomical Context for Aggressive Periodontitis

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33MalaCards
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MalaCards organs/tissues related to Aggressive Periodontitis:

33
Bone, Monocytes, Whole blood, Colon, T cells

Animal Models for Aggressive Periodontitis or affiliated genes

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37MGI
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MGI Mouse Phenotypes related to Aggressive Periodontitis:

37
idDescriptionMGI Source AccessionScoreTop Affiliating Genes
1MP:00053977.9FPR1, IL1A, FCER1A, FCGR2A, CYBA
2MP:00053876.7FPR1, DEFB1, CYBA, FCGR2A, FCER1A, MMP8

Publications for Aggressive Periodontitis

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52PubMed
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Articles related to Aggressive Periodontitis:

(show top 50)    (show all 445)
idTitleAuthorsYear
1
Correlation of Aggregatibacter actinomycetemcomitans Detection with Clinical/Immunoinflammatory Profile of Localized Aggressive Periodontitis Using a 16S rRNA Microarray Method: A Cross-Sectional Study. (24376864)
2013
2
Bimaxillary unilateral gingival fibromatosis with localized aggressive periodontitis (eating the tooth at the same table). (24124307)
2013
3
Aggressive periodontitis diagnosed during or before orthodontic treatment. (23210838)
2013
4
Template-guided flapless implant insertion and prosthetic rehabilitation with telescopic crowns in a patient with treated generalized aggressive periodontitis: a case report. (22299117)
2012
5
Generalized aggressive periodontitis and its treatment options: case reports and review of the literature. (22291715)
2012
6
Microbiological characterization in children with aggressive periodontitis. (22863892)
2012
7
Treatment of generalised aggressive periodontitis: a 4-year follow-up case report. (22866285)
2012
8
Antimicrobial photodynamic therapy in the non-surgical treatment of aggressive periodontitis: microbiological profile. (21399951)
2012
9
Detection of human herpes viruses in patients with chronic and aggressive periodontitis and relationship between viruses and clinical parameters. (22923891)
2012
10
Prevalence of Aggregatibacter actinomycetemcomitans in Sudanese patients with aggressive periodontitis: a case-control study. (21332472)
2011
11
Report of a case of Turner's syndrome with localized aggressive periodontitis. (21976844)
2011
12
Genetic study of families affected with aggressive periodontitis. (21501238)
2011
13
The clinical assessment of aggressive periodontitis patients. (21811690)
2011
14
Local inflammatory markers and systemic endotoxin in aggressive periodontitis. (21730256)
2011
15
Volumetric analysis of intrabony defects in aggressive periodontitis patients following use of a novel composite alloplast: a pilot study. (21519556)
2011
16
Amoxicillin and metronidazole as an adjunctive treatment in generalized aggressive periodontitis at initial therapy or re-treatment: a randomized controlled clinical trial. (21062335)
2011
17
Investigation of the interleukin-1 gene cluster polymorphisms in Jordanian patients with chronic and aggressive periodontitis. (21035110)
2011
18
Genetic power of a Brazilian three-generation family with generalized aggressive periodontitis. II. (21519652)
2011
19
Response of chronic and aggressive periodontitis to treatment. (20403111)
2010
20
Genetic power of a Brazilian three-generation family with generalized aggressive periodontitis. (20640360)
2010
21
IL-1 gene cluster is not linked to aggressive periodontitis. (20335539)
2010
22
Eosinophilic granuloma or aggressive periodontitis?]. (20074763)
2010
23
Histopathological features of chronic and aggressive periodontitis. (20403104)
2010
24
Immunologic and microbiologic profiles of chronic and aggressive periodontitis subjects. (20450404)
2010
25
Unusual gingival enlargement with aggressive periodontitis: a case report. (20461324)
2010
26
FBAT analysis of polymorphisms of vitamin D receptor (Taq I and Fok I) in aggressive periodontitis families]. (20140038)
2010
27
Management of infrabony defects in mandibular molars in a patient with generalized aggressive periodontitis using autogenous bone graft from maxillary tuberosity. (20922081)
2010
28
Supernumerary eumorphic mandibular incisor in association with aggressive periodontitis. (21691553)
2010
29
Aggressive periodontitis and chronic arthritis: blood mononuclear cell gene expression and plasma protein levels of cytokines and cytokine inhibitors. (19186969)
2009
30
Ceruloplasmin induces polymorphonuclear leukocyte priming in localized aggressive periodontitis. (19656030)
2009
31
Relationship of neutrophil phagocytosis and oxidative burst with the subgingival microbiota of generalized aggressive periodontitis. (19239639)
2009
32
Risk of aggressive periodontitis in adolescent carriers of the JP2 clone of Aggregatibacter (Actinobacillus) actinomycetemcomitans in Morocco: a prospective longitudinal cohort study. (18207019)
2008
33
Interleukin-1 and tumor necrosis factor-alpha gene polymorphisms in Turkish patients with localized aggressive periodontitis. (18587204)
2008
34
Association of vitamin D receptor gene polymorphisms in Chinese patients with generalized aggressive periodontitis. (18205735)
2008
35
Platelet-rich plasma in combination with bovine derived xenograft in the treatment of generalized aggressive periodontitis: a case report with re-entry. (17957570)
2007
36
Aggregatibacter actinomycetemcomitans as indicator for aggressive periodontitis by two analysing strategies. (17433043)
2007
37
Timing affects the clinical outcome of adjunctive systemic antibiotic therapy for generalized aggressive periodontitis. (17608574)
2007
38
Demographic, clinical, and microbial aspects of chronic and aggressive periodontitis in Colombia: a multicenter study. (17397309)
2007
39
Incomplete adherence to an adjunctive systemic antibiotic regimen decreases clinical outcomes in generalized aggressive periodontitis patients: a pilot retrospective study. (17711478)
2007
40
NADPH oxidase (CYBA) and FcgammaR polymorphisms as risk factors for aggressive periodontitis: a case-control association study. (16899095)
2006
41
Expressions of selected adhesion molecules on peripheral blood leukocytes in patients with aggressive periodontitis. (15995587)
2005
42
Cytokine profile in gingival crevicular fluid of aggressive periodontitis: influence of smoking and stress. (15367195)
2004
43
The -308 polymorphism in the promoter region of the tumor necrosis factor-alpha (TNF-alpha) gene and ex vivo lipopolysaccharide-induced TNF-alpha expression in patients with aggressive periodontitis and/or type 1 diabetes mellitus. (15627647)
2004
44
Aggressive periodontitis of the primary dentition associated with idiopathic immune deficiency: case report and treatment considerations. (15554399)
2004
45
Clinical and radiographic evaluation of Emdogain as a regenerative material in the treatment of interproximal vertical defects in chronic and aggressive periodontitis patients. (15119889)
2004
46
Identification of mRNAs for the various diacylglycerol kinase isoforms in neutrophils from patients with localized aggressive periodontitis. (12941073)
2003
47
Distribution of periodontal pathogens in Korean aggressive periodontitis. (14584866)
2003
48
Lactoferrin iron levels are reduced in saliva of patients with localized aggressive periodontitis. (12083535)
2002
49
Can presence or absence of periodontal pathogens distinguish between subjects with chronic and aggressive periodontitis? A systematic review. (12787203)
2002
50
Differential gene expression in neutrophils from patients with generalized aggressive periodontitis. (11762875)
2001

Variations for Aggressive Periodontitis

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Expression for genes affiliated with Aggressive Periodontitis

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2BioGPS, 15Gene Expression Omnibus DataSets
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Expression patterns in normal tissues for genes affiliated with Aggressive Periodontitis

Search GEO for disease gene expression data for Aggressive Periodontitis.

Pathways for genes affiliated with Aggressive Periodontitis

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50PathCards, 53QIAGEN, 30KEGG
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Compounds for genes affiliated with Aggressive Periodontitis

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51PharmGKB, 11DrugBank, 45Novoseek, 61Tocris Bioscience, 24HMDB, 29IUPHAR, 3BitterDB
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Compounds related to Aggressive Periodontitis according to GeneCards/GeneDecks:

(show top 50)    (show all 51)
idCompoundScoreTop Affiliating Genes
1tositumomab51 1111.1FCGR2A, FCGR3B
2ibritumomab51 1111.1FCGR3B, FCGR2A
3alefacept45 1111.1FCGR3B, FCGR2A
4bevacizumab51 1111.1FCGR3B, FCGR2A
5efalizumab45 1111.1FCGR2A, FCGR3B
6cytochalasin b4510.1FPR1, FCGR3B
7daclizumab45 1111.1FCGR2A, FCGR3B
8basiliximab45 1111.1FCGR3B, FCGR2A
9natalizumab45 1111.1FCGR2A, FCGR3B
10alemtuzumab45 1111.1FCGR2A, FCGR3B
11gemtuzumab ozogamicin51 45 1112.1FCGR3B, FCGR2A
12adalimumab45 51 1112.1FCGR3B, FCGR2A
13ciprofloxacin45 51 1112.1IL1A, DEFB1
14abciximab45 1111.0FCGR3B, FCGR2A
15polymyxin b4510.0IL1A, DEFB1
16cetuximab45 51 1112.0FCGR3B, FCGR2A
17etanercept45 51 1112.0FCGR2A, FCGR3B
18pentoxifylline45 1110.9FPR1, IL1A
19leukotriene b445 61 2411.9FPR1, IL1A, FCGR3B
20ivig459.9IL1A, FCGR2A
21trastuzumab45 51 1111.8FCGR3B, FCGR2A
22rantes459.8DEFB1, IL1A, FPR1
23rituximab45 51 1111.7FCGR2A, FCGR3B
24hocl459.7MMP8, CYBA
25phosphoinositide459.7FCGR2A, FCGR3B, FPR1
26fluvastatin45 51 29 1112.6IL1A, CYBA
27mannose459.6FCAR, FCGR3B, FCGR2A
28dbc-amp459.6FPR1, FCGR3B
29tetracycline45 1110.4IL1A, MMP8
30fmlp459.4FCGR2A, FCGR3B, IL1A, FPR1
31n-formylmethionyl-leucylphenylalanine459.4FPR1, IL1A, FCGR3B, CYBA
32cyclosporin a45 29 6111.3FPR1, IL1A, MMP8
33nadph45 2410.3CYBA, FCGR2A, FCGR3B, FPR1
34pge2459.3FPR1, IL1A, MMP8
35glutamine459.3CYBA, FCGR2A, IL1A
36genistein45 29 61 3 24 1114.3FPR1, IL1A, MMP8, FCGR3B
37dexamethasone45 51 29 1112.2FPR1, IL1A, CYBA, DEFB1
38arachidonic acid45 29 24 1112.2CYBA, FCGR2A, IL1A, FPR1
39heparin45 29 24 1112.2FPR1, IL1A, FCGR2A
40histamine45 29 2411.2FCGR2A, FCER1A, FPR1
41retinoic acid45 2410.1FPR1, IL1A, MMP8, DEFB1
42nitric oxide45 24 1110.9FPR1, IL1A, MMP8, CYBA
43oligonucleotide458.9CYBA, FCGR2A, MMP8, FPR1
44tyrosine458.7CYBA, FCGR2A, FCGR3B, FCAR, FPR1
45lipid458.7CYBA, FCGR2A, FCGR3B, MMP8, FPR1
46superoxide45 249.6CYBA, FCGR3B, FCAR, MMP8, FPR1
47oxygen45 249.5CYBA, FCGR2A, FCAR, MMP8, FPR1
48calcium45 51 24 1111.3DMP1, CYBA, FCGR2A, FCGR3B, MMP8, FPR1
49h2o2458.3CYBA, FCGR2A, FCGR3B, MMP8, IL1A, FPR1
50serine458.3FCGR2A, FCGR3B, FCAR, MMP8, IL1A, FPR1

GO Terms for genes affiliated with Aggressive Periodontitis

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16Gene Ontology
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Cellular components related to Aggressive Periodontitis according to GeneCards/GeneDecks:

idNameGO IDScoreTop Affiliating Genes
1extracellular regionGO:0055767.9IL1A, MMP8, FCAR, FCGR3B, DMP1, DEFB1

Biological processes related to Aggressive Periodontitis according to GeneCards/GeneDecks:

idNameGO IDScoreTop Affiliating Genes
1immune responseGO:0069558.6IL1A, FCAR, FCGR3B, DEFB1
2innate immune responseGO:0450878.3FCER1A, FCGR2A, CYBA, DEFB1

Molecular functions related to Aggressive Periodontitis according to GeneCards/GeneDecks:

idNameGO IDScoreTop Affiliating Genes
1IgG bindingGO:0198649.7FCGR3B, FCGR2A

Products for genes affiliated with Aggressive Periodontitis

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  • Antibodies
  • Proteins
  • Lysates
  • Antibodies

Sources for Aggressive Periodontitis

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4CDC
13ExPASy
14FMA
22GTR
23HGMD
24HMDB
25ICD10
26ICD10 via Orphanet
27ICD9CM
29IUPHAR
30KEGG
35MeSH
36MESH via Orphanet
37MGI
40NCIt
41NDF-RT
44NINDS
45Novoseek
47OMIM
48OMIM via Orphanet
52PubMed
53QIAGEN
59SNOMED-CT via Orphanet
62UMLS
63UMLS via Orphanet