MCID: AGG001
MIFTS: 48

Aggressive Periodontitis malady

Summaries for Aggressive Periodontitis

About this section
Sources:
8Disease Ontology, 63Wikipedia, 46OMIM, 32MalaCards
See all sources

Fully expand this MalaCard

Export this MalaCard
Disease Ontology:8 A periodontitis that is characterized by rapid attachment loss and bone destruction in the presence of little local factors such as dental plaque and dental calculus resulting in inflammation and a loss of periodontium.

MalaCards: Aggressive Periodontitis, also known as periodontitis, juvenile, is related to periodontitis and gingivitis. An important gene associated with Aggressive Periodontitis is FPR1 (formyl peptide receptor 1), and among its related pathways are Staphylococcus aureus infection and Osteoclast differentiation. The compounds etanercept and adalimumab have been mentioned in the context of this disorder. Affiliated tissues include bone, monocytes and whole blood, and related mouse phenotype immune system.

Wikipedia:63 Aggressive periodontitis describes a type of periodontal disease and includes two of the seven... more...

Description from OMIM:46 608526,170650

Aliases & Classifications for Aggressive Periodontitis

About this section
Sources:
8Disease Ontology, 10DISEASES, 60UMLS, 44Novoseek, 46OMIM, 56SNOMED-CT, 34MeSH
See all sources

Aliases & Descriptions:

aggressive periodontitis 8 10 60
periodontitis, juvenile 60
periodontitis juvenile 44
juvenile periodontitis 8


External Ids:

Disease Ontology8 DOID:1474
SNOMED-CT56 49965002, 2624008
MeSH34 D010520

Related Diseases for Aggressive Periodontitis

About this section
Sources:
17GeneCards, 18GeneDecks
See all sources

Diseases in the Aggressive Periodontitis family:

Periodontitis, Aggressive, 2

Diseases related to Aggressive Periodontitis via text searches within MalaCards or GeneCards/GeneDecks gene sharing:

(show all 49)
idRelated DiseaseScoreTop Affiliating Genes
1periodontitis32.0DEFB1, IL1A, IL1RN
2gingivitis31.2IL1A
3periodontal disease30.7IL1A, IL1RN, DEFB1, CTSC
4arthritis30.5IL1A, FCGR3B, IL1RN, MMP12, FCGR2A
5sarcoidosis30.0IL1RN, IL1A, HLA-S, DEFB1
6periodontosis10.6
7juvenile rheumatoid arthritis10.3
8type 1 diabetes mellitus10.3
9diabetes mellitus10.3
10rheumatoid arthritis10.3
11leukocyte disease10.2
12periodontitis 1, juvenile10.2
13cutaneous lupus erythematosus10.0
14fanconi's anemia10.0
15amelogenesis imperfecta10.0
16rickets10.0
17dental caries10.0
18gingival disease10.0
19intellectual disability10.0
20lupus erythematosus10.0
21tooth disease10.0
22tooth agenesis10.0
23dentinogenesis imperfecta10.0
24pustulosis palmaris et plantaris10.0
25tuberculosis10.0FPR1, CD1A
26celiac disease10.0MMP12
27skin disease10.0IL1A
28sepsis10.0IL1A, DEFB1, FCGR2A, IL1RN, FPR1, FCGR3B
29neutropenia10.0FCGR3B, IL1RN, FPR1
30leukemia10.0CD1A, IL1A, FPR1, FCGR3B, DGKQ
31otitis media10.0DEFB1
32psoriasis10.0HLA-S, IL1A
33hypersensitivity reaction type ii disease10.0IL1A, IL1RN, CD1A, HLA-S, FCGR3B, FCGR2A
34asthma10.0DEFB1, FCER1A, CD1A, MMP12, FCGR3B
35vasculitis10.0FCGR3B
36multiple sclerosis10.0MMP12, IL1RN
37schnitzler syndrome10.0IL1RN
38dermatitis10.0IL1A
39ipex syndrome10.0HLA-S, FPR1, FCGR3B, CTSC, FCGR2A
40colon cancer10.0CTSC, DMP1
41allergic rhinitis10.0FCER1A
42neisseria meningitidis infection10.0FCGR2A, IL1RN
43graves' disease10.0IL1RN, IL1A
44histiocytosis10.0CD1A
45nephritis10.0FCGR2A, FCGR3B, IL1RN
46adenocarcinoma10.0MMP26, MMP12, CTSC
47melanoma10.0MMP26, CD1A, IL1A, MMP12, FCGR2A
48cystic fibrosis10.0DEFB1
49systemic scleroderma10.0IL1A, MMP12, FCGR3B

Graphical network of the top 20 diseases related to Aggressive Periodontitis:



Diseases related to aggressive periodontitis

Clinical Features for Aggressive Periodontitis

About this section
Sources:
46OMIM
See all sources

Clinical features from OMIM:

608526,170650

Drugs & Therapeutics for Aggressive Periodontitis

About this section
Sources:
5CenterWatch, 41NIH Clinical Center, 6ClinicalTrials, 60UMLS, 40NDF-RT
See all sources

Approved drugs:

Search CenterWatch for Aggressive Periodontitis

Drug clinical trials:

Search ClinicalTrials for Aggressive Periodontitis

Search NIH Clinical Center for Aggressive Periodontitis

Search CenterWatch for Aggressive Periodontitis

Genetic Tests for Aggressive Periodontitis

About this section

Anatomical Context for Aggressive Periodontitis

About this section
Sources:
32MalaCards
See all sources

MalaCards organs/tissues related to Aggressive Periodontitis:

32
Bone, Monocytes, Whole blood, Colon, T cells

Animal Models for Aggressive Periodontitis or affiliated genes

About this section
Sources:
36MGI
See all sources

MGI Mouse Phenotypes related to Aggressive Periodontitis:

36
idDescriptionMGI Source AccessionScoreTop Affiliating Genes
1MP:000538710.4FCER1A, FCGR2A, MMP12, FPR1, IL1A, IL1RN

Publications for Aggressive Periodontitis

About this section
Sources:
50PubMed
See all sources

Articles related to Aggressive Periodontitis:

(show top 50)    (show all 465)
idTitleAuthorsYear
1
Correlation of Aggregatibacter actinomycetemcomitans Detection with Clinical/Immunoinflammatory Profile of Localized Aggressive Periodontitis Using a 16S rRNA Microarray Method: A Cross-Sectional Study. (24376864)
2013
2
Elevation of vitamin D-binding protein levels in the plasma of patients with generalized aggressive periodontitis. (22803589)
2013
3
Associations between CD14 -159 C>T polymorphism and chronic/aggressive periodontitis susceptibility. (23517107)
2013
4
A consortium of Aggregatibacter actinomycetemcomitans, Streptococcus parasanguinis, and Filifactor alocis is present in sites prior to bone loss in a longitudinal study of localized aggressive periodontitis. (23784124)
2013
5
Unusual gingival fibromatosis with aggressive periodontitis. (23518779)
2013
6
Clinical results after nonsurgical therapy in aggressive and chronic periodontitis. (23749245)
2013
7
Association of vitamin D receptor gene polymorphisms with chronic and aggressive periodontitis in Jordanian patients. (24102630)
2013
8
Outcomes of dental implant treatment in patients with generalized aggressive periodontitis: a systematic review. (23236573)
2012
9
Clinical efficacy of 1% alendronate gel in adjunct to mechanotherapy in the treatment of aggressive periodontitis: a randomized controlled clinical trial. (21609254)
2012
10
Genetic power of a Brazilian three-generation family with generalized aggressive periodontitis. II. (21519652)
2011
11
Patient-related risk factors for tooth loss in aggressive periodontitis after active periodontal therapy. (21284688)
2011
12
Single nucleotide polymorphisms in interleukin-1gene cluster and subgingival colonization with Aggregatibacter actinomycetemcomitans in patients with aggressive periodontitis. (21672595)
2011
13
"What is there in a name?": A literature review on chronic and aggressive periodontitis. (22368353)
2011
14
Impact of systemic antimicrobials combined with anti-infective mechanical debridement on the microbiota of generalized aggressive periodontitis: a 6-month RCT. (21303403)
2011
15
Aggressive periodontitis: the historic quest for understanding. (21823495)
2011
16
Diversity and quantitative analysis of Archaea in aggressive periodontitis and periodontally healthy subjects. (21539593)
2011
17
FAM5C contributes to aggressive periodontitis. (20383335)
2010
18
Relationship of neutrophil phagocytosis and oxidative burst with the subgingival microbiota of generalized aggressive periodontitis. (19239639)
2009
19
TNF-alpha and IL-4 levels in generalized aggressive periodontitis subjects. (18992018)
2009
20
Association of SNPs in N-formylpeptide receptor gene with susceptibility of aggressive periodontitis]. (20019777)
2009
21
Formylpeptide receptor single nucleotide polymorphism 348T>C and its relationship to polymorphonuclear leukocyte chemotaxis in aggressive periodontitis. (19722801)
2009
22
Evaluation of the humoral immune response to the cytolethal distending toxin of Aggregatibacter actinomycetemcomitans Y4 in subjects with localized aggressive periodontitis. (19239638)
2009
23
Cathepsin C gene variants in aggressive periodontitis. (18809751)
2008
24
Association between interleukin-6 promoter haplotypes and aggressive periodontitis. (18269659)
2008
25
Human beta-defensin-1 and -2 and matrix metalloproteinase-25 and -26 expression in chronic and aggressive periodontitis and in peri-implantitis. (17996844)
2008
26
Aggregatibacter actinomycetemcomitans as indicator for aggressive periodontitis by two analysing strategies. (17433043)
2007
27
Combined periodontal and implant treatment of a case of aggressive periodontitis. (17987861)
2007
28
Influence of periodontal therapy on the regulation of soluble cell adhesion molecule expression in aggressive periodontitis patients. (17397316)
2007
29
Antimicrobial photodynamic therapy in the non-surgical treatment of aggressive periodontitis: a preliminary randomized controlled clinical study. (17539707)
2007
30
Implant-supported reconstruction in a patient with generalized aggressive periodontitis. (17397329)
2007
31
Distribution of FcgammaRIIa and FcgammaRIIIb genotypes in patients with generalized aggressive periodontitis. (16805673)
2006
32
Subgingival microbiota of periodontally untreated Mexican subjects with generalized aggressive periodontitis. (17092239)
2006
33
The outcome of a preventive dental care programme on the prevalence of localized aggressive periodontitis in Down's syndrome individuals. (16774634)
2006
34
Aggressive periodontitis among young Israeli army personnel. (16881808)
2006
35
C-reactive protein levels in patients with aggressive periodontitis. (16734565)
2006
36
Aggressive periodontitis in a 16-year-old Ghanaian adolescent, the original source of Actinobacillus actinomycetemcomitans strain HK1651 - a 10-year follow up. (16879336)
2006
37
Modulation of clinical expression of plaque-induced gingivitis: response in aggressive periodontitis subjects. (16441729)
2006
38
Rehabilitative management offered Nigerian localized and generalized aggressive periodontitis patients. (16127471)
2005
39
CD38 expression in neutrophils from patients with localized aggressive periodontitis. (16274316)
2005
40
Association of matrix metalloproteinase-1 promoter polymorphism with generalized aggressive periodontitis in a Chinese population. (16302919)
2005
41
The -308 polymorphism in the promoter region of the tumor necrosis factor-alpha (TNF-alpha) gene and ex vivo lipopolysaccharide-induced TNF-alpha expression in patients with aggressive periodontitis and/or type 1 diabetes mellitus. (15627647)
2004
42
Clinical and radiographic evaluation of Emdogain as a regenerative material in the treatment of interproximal vertical defects in chronic and aggressive periodontitis patients. (15119889)
2004
43
Intraosseous sarcoidosis of the jaws mimicking aggressive periodontitis: a case report and literature review. (15088887)
2004
44
Distribution of periodontal pathogens in Korean aggressive periodontitis. (14584866)
2003
45
Are there HLA combinations typical supporting for or making resistant against aggressive and/or chronic periodontitis? (12941076)
2003
46
Localized aggressive periodontitis in primary dentition: a case report. (12931770)
2003
47
Antimicrobials for the treatment of aggressive periodontitis. (12974531)
2003
48
Prevalence of human herpesviruses in patients with aggressive periodontitis. (14682660)
2003
49
Resolution of crevicular fluid leukocyte activity in patients treated for aggressive periodontal disease. (12296600)
2002
50
Three case reports of aggressive periodontitis associated with Porphyromonas gingivalis in younger patients. (12366854)
2002

Genetic Variations for Aggressive Periodontitis

About this section

Expression for genes affiliated with Aggressive Periodontitis

About this section
Sources:
1BioGPS, 15Gene Expression Omnibus DataSets
See all sources
Expression patterns in normal tissues for genes affiliated with Aggressive Periodontitis

Search GEO for disease gene expression data for Aggressive Periodontitis.

Pathways for genes affiliated with Aggressive Periodontitis

About this section
Sources:
29KEGG, 51QIAGEN, 37NCBI BioSystems Database
See all sources

Pathways related to Aggressive Periodontitis according to GeneCards/GeneDecks:

idSuper pathways (with members indented)ScoreTop Affiliating Genes
110.5FCGR2A, FCGR3B, FPR1
210.5FCGR2A, FCGR3B, IL1A
310.5FCGR3B, FCGR2A, FCER1A
4
Hide members
10.4MMP26, MMP25, MMP12
5
Hide members
10.4FCER1A, FCGR2A, FCGR3B, MMP26, MMP12

Compounds for genes affiliated with Aggressive Periodontitis

About this section
Sources:
44Novoseek, 49PharmGKB, 11DrugBank, 59Tocris Bioscience, 24HMDB, 28IUPHAR
See all sources

Compounds related to Aggressive Periodontitis according to GeneCards/GeneDecks:

(show all 47)
idCompoundScoreTop Affiliating Genes
1etanercept44 49 1112.9FCGR2A, FCGR3B, MMP12, IL1RN
2adalimumab44 49 1112.9IL1RN, FCGR3B, FCGR2A
3fmlp4410.9FCGR2A, FCGR3B, FPR1, IL1A, IL1RN
4n-formylmethionyl-leucylphenylalanine4410.9DGKQ, IL1A, FPR1, FCGR3B
5leukotriene b444 59 2412.9IL1RN, IL1A, FPR1, FCGR3B
62-chloroethyl ethyl sulfide4410.9IL1RN, IL1A
7uk 3833675910.9MMP12, MMP25, MMP26
8polymyxin b4410.9DEFB1, IL1RN, IL1A
9gi 254023x5910.9MMP12, MMP25, MMP26
10gm 60015910.9MMP12, MMP25, MMP26
11histamine44 28 2412.9DGKQ, CTSC, IL1RN, FPR1, FCGR2A, FCER1A
12cellulose triacetate4410.8IL1RN, IL1A
13marimastat44 59 1112.8MMP26, MMP25, MMP12
14h2o24410.8FCGR2A, FCGR3B, FPR1, IL1A, IL1RN, DGKQ
15pentoxifylline44 1111.8FPR1, IL1RN
16ivig4410.8IL1RN, IL1A, FCGR2A
17batimastat44 59 1112.8MMP26, MMP25, MMP12
18rantes4410.8FPR1, IL1A
19phosphoinositide4410.8DGKQ, DGKA, FPR1, FCGR3B, FCGR2A
20Palivizumab1110.8FCGR3B, FCGR2A
21nacl4410.8FPR1, IL1RN, DEFB1, DGKQ
22lipid4410.8DGKQ, DGKA, CD1A, IL1RN, FPR1, MMP12
23phosphatidylinositol4410.8DGKQ, IL1RN, FPR1, MMP12, FCGR3B, FCGR2A
24heparin44 28 11 2413.8CTSC, IL1RN, IL1A, FPR1, FCGR2A
25Intravenous Immunoglobulin1110.8FCGR3B, FCGR2A
26serine4410.8DGKQ, CTSC, IL1RN, IL1A, FPR1, MMP12
27tositumomab49 1111.8FCGR2A, FCGR3B
28calcium44 49 11 2413.8DGKQ, DGKA, DMP1, IL1RN, FPR1, MMP12
29bevacizumab49 1111.8FCGR2A, FCGR3B
30octyl glucoside4410.8DGKQ, FPR1
31dioctanoylglycol5910.8DGKQ, DGKA
32Ibritumomab1110.8FCGR2A, FCGR3B
33alefacept44 1111.8FCGR2A, FCGR3B
34vitamin-e4410.7DGKQ, IL1RN, MMP12
35Muromonab1110.7FCGR3B, FCGR2A
36efalizumab44 1111.7FCGR3B, FCGR2A
37fibrinogen4410.7MMP26, MMP12, FPR1, IL1RN
38daclizumab44 1111.7FCGR3B, FCGR2A
39sodium dodecylsulfate4410.7IL1A, IL1RN, DGKQ
40gold sodium thiomalate4410.6IL1A, IL1RN
41basiliximab44 1111.6FCGR2A, FCGR3B
42gemtuzumab ozogamicin44 1111.6FCGR3B, FCGR2A
43prednisolone44 28 1112.5FCGR2A, FCGR3B, IL1RN
44natalizumab44 1111.5FCGR3B, FCGR2A
45tyrosine4410.4FCGR2A, FCGR3B, MMP12, FPR1, IL1RN, DGKA
46alemtuzumab44 1111.4FCGR3B, FCGR2A
47dexamethasone44 49 28 1113.1DEFB1, IL1RN, IL1A, FPR1, MMP12

GO Terms for genes affiliated with Aggressive Periodontitis

About this section
Sources:
16Gene Ontology
See all sources

Cellular components related to Aggressive Periodontitis according to GeneCards/GeneDecks:

idNameGO IDScoreTop Affiliating Genes
1proteinaceous extracellular matrixGO:00557810.4MMP26, MMP25, MMP12, DMP1

Biological processes related to Aggressive Periodontitis according to GeneCards/GeneDecks:

idNameGO IDScoreTop Affiliating Genes
1immune responseGO:00695510.4FCGR3B, IL1A, IL1RN, CD1A, DEFB1, CTSC

Molecular functions related to Aggressive Periodontitis according to GeneCards/GeneDecks:

idNameGO IDScoreTop Affiliating Genes
1IgG bindingGO:01986410.5FCGR2A, FCGR3B
2interleukin-1 receptor bindingGO:00514910.5IL1A, IL1RN
3NAD+ kinase activityGO:00395110.4DGKA, DGKQ
4metalloendopeptidase activityGO:00422210.3MMP12, MMP25, MMP26
5diacylglycerol kinase activityGO:00414310.1DGKA, DGKQ

Products for genes affiliated with Aggressive Periodontitis

About this section
  • Antibodies
  • Proteins
  • Lysates
  • Antibodies

Sources for Aggressive Periodontitis

About this section
3CDC
13ExPASy
14FMA
22GTR
23HGMD
24HMDB
25ICD10
26ICD10 via Orphanet
27ICD9CM
28IUPHAR
29KEGG
34MeSH
35MESH via Orphanet
36MGI
39NCIt
40NDF-RT
43NINDS
44Novoseek
46OMIM
47OMIM via Orphanet
50PubMed
51QIAGEN
57SNOMED-CT via Orphanet
60UMLS
61UMLS via Orphanet