MCID: AGG001
MIFTS: 49

Aggressive Periodontitis

Categories: Oral diseases

Aliases & Classifications for Aggressive Periodontitis

MalaCards integrated aliases for Aggressive Periodontitis:

Name: Aggressive Periodontitis 12 42 14
Periodontitis, Juvenile 69
Juvenile Periodontitis 12

Classifications:



External Ids:

Disease Ontology 12 DOID:1474
ICD10 33 K05.2
MeSH 42 D010520
UMLS 69 C0031106

Summaries for Aggressive Periodontitis

Disease Ontology : 12 A periodontitis that is characterized by rapid attachment loss and bone destruction in the presence of little local factors such as dental plaque and dental calculus resulting in inflammation and a loss of periodontium.

MalaCards based summary : Aggressive Periodontitis, also known as periodontitis, juvenile, is related to rheumatoid arthritis and susceptibility to localized juvenile periodontitis. An important gene associated with Aggressive Periodontitis is IL1B (Interleukin 1 Beta), and among its related pathways/superpathways are Innate Immune System and PEDF Induced Signaling. The drugs Estradiol and Ethinyl Estradiol have been mentioned in the context of this disorder. Affiliated tissues include bone, neutrophil and monocytes, and related phenotypes are hematopoietic system and homeostasis/metabolism

Wikipedia : 72 Aggressive periodontitis describes a type of periodontal disease and includes two of the seven... more...

Related Diseases for Aggressive Periodontitis

Diseases in the Aggressive Periodontitis family:

Periodontitis, Aggressive, 2

Diseases related to Aggressive Periodontitis via text searches within MalaCards or GeneCards Suite gene sharing:

(show top 50) (show all 308)
id Related Disease Score Top Affiliating Genes
1 rheumatoid arthritis 26.5 CXCL8 IL10 IL1A IL1B IL1RN IL4
2 susceptibility to localized juvenile periodontitis 11.9
3 periodontitis 1, juvenile 11.0
4 periodontitis 10.9
5 pure autonomic failure 10.9 IL10 TNF
6 toxic optic neuropathy 10.8 IL1A IL1B
7 smarca4-deficient sarcoma of thorax 10.8 IL6 TNF
8 tabatznik syndrome 10.8 IL1B TNF
9 sternal cleft 10.8 IL1B TNF
10 lung sarcoma 10.7 IL1A IL1B TNF
11 eye accommodation disease 10.7 IL10 IL4
12 walker dyson syndrome 10.7 IL1B IL1RN TNF
13 gastric cancer risk after h. pylori infection 10.7 IL1B IL1RN
14 aortic arch interruption 10.7 IL6 TNF
15 mental retardation dysmorphism hypogonadism diabetes 10.7 IL1A IL1B IL1RN
16 upper gum cancer 10.7 IL1B IL6 TNF
17 epstein-barr virus hepatitis 10.7 IL1A IL6 TNF
18 bipolar i disorder 10.7 IL1B IL6 TNF
19 urethra transitional cell carcinoma 10.7 IL10 IL1A TNF
20 tinea favosa 10.7 IL1B IL6 TNF
21 central nervous system leiomyosarcoma 10.7 IL1B IL6 TNF
22 multiple familial trichoepithelioma 10.7 IL10 TNF
23 cutaneous leishmaniasis 10.7 IL6 TNF
24 ethmoid sinus adenocarcinoma 10.7 IL10 IL6 TNF
25 ampulla of vater neoplasm 10.7 IL1B IL6 TNF
26 acute ackee fruit intoxication 10.7 IL10 IL4 TNF
27 brucella canis brucellosis 10.7 IL1B IL6 TNF
28 foodborne botulism 10.7 IL1B IL6 TNF
29 human monocytic ehrlichiosis 10.7 IL1B IL6 TNF
30 lagophthalmos 10.6 IL10 IL4 TNF
31 cyclosporiasis 10.6 IL10 IL6 TNF
32 epileptic encephalopathy, early infantile, 7 10.6 IL1A IL1B IL6
33 crystal arthropathies 10.6 IL1RN IL6
34 hepadnavirus infection 10.6 IL10 IL6 TNF
35 ulcerative colitis 10.6 IL10 IL6 TNF
36 hemophagocytic lymphohistiocytosis 10.6 IL10 IL6 TNF
37 liver leiomyoma 10.6 IL10 IL4 TNF
38 pancreas lymphoma 10.6 IL1B IL6 TNF
39 conduct disorder 10.6 IL10 IL6 TNF
40 oropharyngeal cancer, childhood 10.6 IL10 IL4 TNF
41 ileitis 10.6 IL1B IL4
42 plummer's disease 10.6 IL10 IL6 TNF
43 uterine adnexa cancer 10.6 IL1B IL6 TNF
44 amyotrophic lateral sclerosis type 10 10.6 CXCL8 IL1B TNF
45 disease of mental health 10.6 IL10 IL6 TNF
46 lymph node palisaded myofibroblastoma 10.6 CXCL8 IL10 IL1A
47 tularemia 10.6 IL10 IL4 TNF
48 epulis 10.6 CXCL8 IL1B TNF
49 extrahepatic bile duct adenocarcinoma 10.6 IL10 IL6 TNF
50 philophthalmiasis 10.6 IL1B IL4 IL6

Graphical network of the top 20 diseases related to Aggressive Periodontitis:



Diseases related to Aggressive Periodontitis

Symptoms & Phenotypes for Aggressive Periodontitis

MGI Mouse Phenotypes related to Aggressive Periodontitis:

44
id Description MGI Source Accession Score Top Affiliating Genes
1 hematopoietic system MP:0005397 10.15 CTSC FCGR2A FPR1 IL10 IL1A IL1B
2 homeostasis/metabolism MP:0005376 10.13 IL10 IL1A IL1B IL1RN IL4 IL6
3 immune system MP:0005387 10.1 CTSC FCGR2A FPR1 IL10 IL1A IL1B
4 integument MP:0010771 9.85 CTSC IL10 IL1A IL1B IL1RN IL4
5 neoplasm MP:0002006 9.61 MMP8 TLR4 TNF TNFSF11 IL10 IL1A
6 skeleton MP:0005390 9.28 FCGR2A IL10 IL1B IL1RN IL4 IL6

Drugs & Therapeutics for Aggressive Periodontitis

Drugs for Aggressive Periodontitis (from DrugBank, HMDB, Dgidb, PharmGKB, IUPHAR, NovoSeek, BitterDB):

(show top 50) (show all 58)
id Name Status Phase Clinical Trials Cas Number PubChem Id
1
Estradiol Approved, Investigational, Vet_approved Phase 4 50-28-2 5757
2
Ethinyl Estradiol Approved Phase 4 57-63-6 5991
3
Moxifloxacin Approved, Investigational Phase 4 354812-41-2, 151096-09-2 152946
4
Norgestimate Approved Phase 4 35189-28-7 6540478
5
Chlorhexidine Approved, Vet_approved Phase 4 55-56-1 9552079 2713
6
Amoxicillin Approved, Vet_approved Phase 4,Phase 2,Phase 3 26787-78-0 33613 2171
7
Metronidazole Approved Phase 4,Phase 2,Phase 3 443-48-1 4173
8 Anti-Bacterial Agents Phase 4,Phase 2,Phase 3
9 Anti-Infective Agents Phase 4,Phase 2,Phase 3
10 Contraceptive Agents Phase 4
11 Contraceptives, Oral Phase 4
12 Contraceptives, Oral, Combined Phase 4
13 Estradiol 17 beta-cypionate Phase 4
14 Estradiol 3-benzoate Phase 4
15 Estradiol valerate Phase 4 979-32-8
16 Fluoroquinolones Phase 4
17 Norgestimate, ethinyl estradiol drug combination Phase 4
18 Nucleic Acid Synthesis Inhibitors Phase 4
19 Polyestradiol phosphate Phase 4
20 Topoisomerase Inhibitors Phase 4
21 Chlorhexidine gluconate Phase 4
22 Antibiotics, Antitubercular Phase 4,Phase 2,Phase 3
23 Antiparasitic Agents Phase 4,Phase 2,Phase 3
24 Antiprotozoal Agents Phase 4,Phase 2,Phase 3
25 Anesthetics Phase 4
26 Anesthetics, Local Phase 4
27
Clarithromycin Approved Phase 2, Phase 3 81103-11-9 84029
28
Aspirin Approved, Vet_approved Phase 2, Phase 3 50-78-2 2244
29 Cytochrome P-450 CYP3A Inhibitors Phase 2, Phase 3
30 Cytochrome P-450 Enzyme Inhibitors Phase 2, Phase 3
31 Analgesics Phase 2, Phase 3
32 Analgesics, Non-Narcotic Phase 2, Phase 3
33 Anti-Inflammatory Agents Phase 2, Phase 3
34 Anti-Inflammatory Agents, Non-Steroidal Phase 2, Phase 3
35 Antipyretics Phase 2, Phase 3
36 Antirheumatic Agents Phase 2, Phase 3
37 Cyclooxygenase Inhibitors Phase 2, Phase 3
38 Fibrinolytic Agents Phase 2, Phase 3
39 Peripheral Nervous System Agents Phase 2, Phase 3
40 Platelet Aggregation Inhibitors Phase 2, Phase 3
41 Omega 3 Fatty Acid Nutraceutical Phase 2, Phase 3
42
Nitric Oxide Approved 10102-43-9 145068
43
Ergocalciferol Approved, Nutraceutical 50-14-6 5280793
44
Vitamin D Approved, Nutraceutical, Vet_approved 1406-16-2
45 Antibodies
46 Immunoglobulin A
47 Immunoglobulins
48 Bone Density Conservation Agents
49 Dihydroxycholecalciferols
50 Ergocalciferols

Interventional clinical trials:

(show all 38)

id Name Status NCT ID Phase Drugs
1 Adjunctive Systemic Administration of Moxifloxacin in the Treatment of Aggressive Periodontitis Completed NCT02125812 Phase 4
2 Evaluation of Efficacy of Full-mouth Disinfection in Generalized Aggressive Periodontitis Patients Completed NCT02466646 Phase 4 Klorhex® Gel, rinse and sprey
3 Treatment of Aggressive Periodontitis With Repeated Adjunctive Antimicrobial Photodynamic Therapy Completed NCT02049008 Phase 4
4 Host Modulatory Effects of β-glucan on Localized Aggressive Periodontitis Completed NCT02402296 Phase 4 β-1,3/1,6-D-glucan
5 Alternative Antibiotic Regime in the Treatment of GAgP Completed NCT02223702 Phase 4 Amoxicillin;Metronidazole;Moxifloxacin
6 Effects of the Variation in the Time of Systemic Administration of Metronidazole and Amoxicillin Associated to the Non-surgical Therapy of Chronic Periodontitis. Completed NCT01211223 Phase 4 Administration of Metronidazole plus Amoxicillin
7 Antimicrobial Therapy as Adjunct to Periodontal Treatment: Effect of Timing Completed NCT02197260 Phase 4 3/d 500 mg metronidazole plus 375 mg amoxicillin for 7 days
8 Efficacy of Three Antibiotic Protocols for Aggressive Periodontitis Treatment Recruiting NCT02839421 Phase 4 Scaling and Root Planing combined with moxifloxacin
9 Enamel Matrix Proteins in the Treatment of Intrabony Defects in Patients With Aggressive and Chronic Periodontitis Recruiting NCT03025204 Phase 4
10 Two Different Antibiotic Agents to Treat Generalized Aggressive Periodontitis Completed NCT02969928 Phase 2, Phase 3 Clarithromycin;Amoxicillin;Metronidazole
11 Periodontal Debridement Associated With Systemic Antibiotics and Single/Repeated PDT to Treat Aggressive Periodontitis Completed NCT03132714 Phase 2, Phase 3 Amoxicillin 500mg;Metronidazole 400mg;Clarithromycin 500mg
12 Omega-3 Plus Low-dose Aspirin Daily Supplementation in Non-surgical Therapy to Treat Aggressive Periodontitis Recruiting NCT03093246 Phase 2, Phase 3 Aspirin
13 Omega-3 Fatty Acids Plus Low-dose Aspirin Daily Supplementation in Surgical Therapy to Treat Aggressive Periodontitis Recruiting NCT03093207 Phase 2, Phase 3 Aspirin
14 The Affect of Orthodontic Treatment on the Periodontal Status of Patients With Aggressive Periodontitis Unknown status NCT01510808
15 Analysis of Osteoimmune Interactions Linking Inflammation and Bone Destruction in Aggressive Periodontitis Unknown status NCT01993368
16 Polymorphonuclear Cells' Sensitivity to Aggregatibacter Actinomycetemcomitans Bacteria in Patients With Aggressive Periodontitis Unknown status NCT02010307
17 Chronic Presence of Epstein Barr Virus in Epithelial Cells From Gingiva is Associated With Periodontitis Unknown status NCT01246596
18 Chronic Presence of Epstein Barr Virus in Sulcular and Junctional Epithelial Tissue From Gingiva is Associated With Severe Periodontitis Unknown status NCT01246648
19 Immunolocalization of 1,25,Dihydroxyvitamin D3 in Aggressive Periodontitis Patients Completed NCT02282800
20 Gene Expression Profiles in Generalized Aggressive Periodontitis: A Gene Network-based Microarray Analysis Completed NCT02327533 Early Phase 1
21 Gingival Crevicular Fluid Levels Of Monocyte Chemoattractant Protein-1 Completed NCT02927704
22 Frequency Of MCP-1 And CCR2 Gene Polymorphisms And Its Effect On Gene Expression In Patients With AgP Completed NCT02817568
23 Effects of Er,Cr:YSGG, Diode Lasers on GCF Cytokines Levels Completed NCT03034824
24 Clarithromycin as Adjuvant to Periodontal Debridement Completed NCT02829983 Clarithromycin;Placebo
25 Smoking Influence on Apoptosis in Periodontitis Completed NCT02111005
26 Nonsurgical Periodontal Treatment Associated or Not With Systemic Antibiotics and Photodynamic Therapy Completed NCT03142776 systemic clarithromycin
27 Estimation of Pentrexin-3 Levels in GCF and Saliva of Patients With Periodontal Disease Completed NCT03128502
28 Effect of Surgical Therapy on RANKL/OPG (Osteoprotegerin) System Completed NCT02190773
29 Nitro-oxidative Stress in Periodontitis Completed NCT02127203
30 The Importance of Periostin in Periodontal Health and Disease Completed NCT01180920
31 Gingival Bleeding and Von Willebrand Disease Typ 2 and 3 Completed NCT03078595
32 Immediate Implant Placement in Aggressive Periodontitis Recruiting NCT03218228
33 Mechanisms and Treatment Response of Aggressive Periodontitis in Children Recruiting NCT01330719
34 Subgingival Microbiome Following Mechanical Treatment and it's Effect on Peri-implant Sub-mucosa in Aggressive Periodontitis Patients Recruiting NCT03090282
35 B Cell Functions in Periodontitis Recruiting NCT02833285
36 Interaction Between Immune Cells and Bacteria Associated With Periodontitis Recruiting NCT03225950
37 Comparison Between Surgical Access and Repeated Applications of APDT Active, not recruiting NCT03140059
38 Long-term Results After Systematic Periodontal Therapy Enrolling by invitation NCT03048045

Search NIH Clinical Center for Aggressive Periodontitis

Cochrane evidence based reviews: aggressive periodontitis

Genetic Tests for Aggressive Periodontitis

Anatomical Context for Aggressive Periodontitis

MalaCards organs/tissues related to Aggressive Periodontitis:

39
Bone, Neutrophil, Monocytes, B Cells, Whole Blood, Colon, T Cells

Publications for Aggressive Periodontitis

Articles related to Aggressive Periodontitis:

(show top 50) (show all 572)
id Title Authors Year
1
Clarithromycin as an Adjunct to One-Stage Full Mouth Ultrasonic Periodontal Debridement in Generalized Aggressive Periodontitis: a Randomized Controlled Clinical Trial. ( 28671507 )
2017
2
Long-term treatment costs for aggressive periodontitis in a German population. ( 28905412 )
2017
3
Local and Plasma Biomarker Profiles in Localized Aggressive Periodontitis. ( 28879248 )
2017
4
Biomarker levels in gingival crevicular fluid of generalized aggressive periodontitis patients after non-surgical periodontal treatment. ( 28918557 )
2017
5
Autologous Platelet Rich Fibrin in the Treatment of 3-Wall Intrabony Defects in Aggressive Periodontitis - A Randomized Controlled Clinical Trial. ( 28820320 )
2017
6
Comparing the efficiency of Er,Cr:YSGG laser and diode laser on human I^-defensin-1 and IL-1I^ levels during the treatment of generalized aggressive periodontitis and chronic periodontitis. ( 28557642 )
2017
7
Cytokine profile in gingival crevicular fluid and plasma of patients with aggressive periodontitis. ( 28868949 )
2017
8
Treatment compliance in patients with aggressive periodontitis - a retrospective case-control study. ( 27899029 )
2017
9
IL-6 and IL-10 gene polymorphisms in patients with aggressive periodontitis: effects on GCF, serum and clinic parameters. ( 28099578 )
2017
10
Transcriptome of Healthy Gingival Tissue from Edentulous Sites in Patients with a History of Aggressive Periodontitis. ( 28844188 )
2017
11
Disease Staging Index for Aggressive Periodontitis. ( 28831460 )
2017
12
Effect of scaling & root planing on the activity of ALP in GCF & serum of patients with gingivitis, chronic and aggressive periodontitis: A comparative study. ( 28706787 )
2017
13
The Effects of Diode Laser Therapy as an Adjunct to Scaling and Root Planing in the Treatment of Aggressive Periodontitis: A 1-Year Randomized Controlled Clinical Trial. ( 28945145 )
2017
14
Salivary and Serum Markers Related to Innate Immunity in Generalized Aggressive Periodontitis. ( 28753101 )
2017
15
Towards the targeted management of aggressive periodontitis. ( 28571797 )
2017
16
Aggregatibacter actinomycetemcomitans in African Americans with Localized Aggressive Periodontitis. ( 28879247 )
2017
17
Non-Surgical Therapy Reduces Presence of JP2 Clone in Localized Aggressive Periodontitis. ( 28820321 )
2017
18
Association of NOD2 Mutations with Aggressive Periodontitis. ( 28682159 )
2017
19
The Effect of Nonsurgical Periodontal Therapy on the Level of Human Neutrophil Peptides 1-3 in Patients with Aggressive Periodontitis. ( 28944351 )
2017
20
Immature, but Not Mature, Dendritic Cells Are More Often Present in Aggressive Periodontitis Than Chronic Periodontitis: An Immunohistochemical Study. ( 28841097 )
2017
21
Epigenetic regulation of inflammation in localized aggressive periodontitis. ( 28883894 )
2017
22
More than two-thirds of patients with localized aggressive periodontitis gained more than 2 millimeters of clinical attachment level after 4 years of maintenance treatment. ( 28666521 )
2017
23
Gingival crevicular fluid and serum hCAP18/LL-37 levels in generalized aggressive periodontitis. ( 27129587 )
2016
24
Peri-implant and periodontal microbiome diversity in aggressive periodontitis patients: a pilot study. ( 27170047 )
2016
25
Trends in Susceptibility to Aggressive Periodontal Disease. ( 28008419 )
2016
26
Antibiotics in aggressive periodontitis, is there a clinical benefit? ( 27980332 )
2016
27
The role of platelets in inflammatory immune responses in generalized aggressive periodontitis. ( 27883202 )
2016
28
Lack of association between the TNF-I+-1031genotypes and generalized aggressive periodontitis disease. ( 27755954 )
2016
29
Adjunct Antimicrobial Therapy and Periodontal Surgery to Treat Generalized Aggressive Periodontitis: A Case Report. ( 27320300 )
2016
30
Total and Differential Leukocyte Counts in the Peripheral Blood of Patients with Generalised Aggressive Periodontitis. ( 27351735 )
2016
31
Porphyromonas gingivalis-induced production of reactive oxygen species, tumor necrosis factor-I+, interleukin-6, CXCL8 and CCL2 by neutrophils from localized aggressive periodontitis and healthy donors: modulating actions of red blood cells and resolvin E1. ( 27146665 )
2016
32
Differentiation of Chronic and Aggressive Periodontitis by FTIR Spectroscopy. ( 27608648 )
2016
33
Gingival Inflammation and Aggressive Periodontitis in a Child with a Specific Antibody Deficiency. ( 27188128 )
2016
34
Periodontal Surgery Involving Modified Widman Flap Procedure and Connective Tissue Graft for Generalized Aggressive Periodontitis: A Case Report. ( 28049974 )
2016
35
Efficacy of Photodynamic Therapy and Lasers as an Adjunct to Scaling and Root Planing in the Treatment of Aggressive Periodontitis - A Clinical and Microbiologic Short Term Study. ( 27042576 )
2016
36
Periodontal regeneration with 0.3% basic fibroblast growth factor (FGF-2) for a patient with aggressive periodontitis: a case report. ( 27021551 )
2016
37
Inflammatory Response Influences Treatment of Localized Aggressive Periodontitis. ( 26917438 )
2016
38
Gingival Crevicular Fluid and Salivary Periostin Levels in Non-Smoker Subjects With Chronic and Aggressive Periodontitis : Periostin Levels in Chronic and Aggressive Periodontitis. ( 26931107 )
2016
39
GC Gene Polymorphisms and Vitamin D-Binding Protein Levels Are Related to the Risk of Generalized Aggressive Periodontitis. ( 28018430 )
2016
40
Long-term clinical response to treatment and maintenance of localized aggressive periodontitis: a cohort study. ( 27767222 )
2016
41
Is there a common pathogenesis in aggressive periodontitis & ankylosing spondylitis in HLA-B27 patient? ( 27063088 )
2016
42
The microbial community shifts of subgingival plaque in patients with generalized aggressive periodontitis following non-surgical periodontal therapy: a pilot study. ( 27732961 )
2016
43
Tumor necrosis factor-I+ G-308A (rs1800629) polymorphism and aggressive periodontitis susceptibility: a meta-analysis of 16 case-control studies. ( 26750615 )
2016
44
Outcomes of implant therapy in patients with a history of aggressive periodontitis. A systematic review and meta-analysis. ( 28013438 )
2016
45
Tooth loss and alveolar bone crest loss during supportive periodontal therapy in patients with generalized aggressive periodontitis: retrospective study with follow-up of 8 to 15 years. ( 27396322 )
2016
46
Treatment of a Periodontic-Endodontic Lesion in a Patient with Aggressive Periodontitis. ( 27418983 )
2016
47
Association of Interleukin-17 polymorphism (-197G/A) in chronic and localized aggressive periodontitis. ( 26910014 )
2016
48
Epigenetic characteristics in inflammatory candidate genes in aggressive periodontitis. ( 26472015 )
2016
49
Effect of patient age awareness on diagnostic agreement of chronic or aggressive periodontitis between clinicians; a pilot study. ( 27456238 )
2016
50
Localized Aggressive Periodontitis Immune Response to Healthy and Diseased Subgingival Plaque. ( 27037664 )
2016

Variations for Aggressive Periodontitis

Expression for Aggressive Periodontitis

Search GEO for disease gene expression data for Aggressive Periodontitis.

Pathways for Aggressive Periodontitis

Pathways related to Aggressive Periodontitis according to GeneCards Suite gene sharing:

(show top 50) (show all 65)
id Super pathways Score Top Affiliating Genes
1
Show member pathways
14.01 CTSC CXCL8 DEFB1 FCGR2A FPR1 IL10
2
Show member pathways
13.7 CXCL8 IL10 IL1A IL1B IL4 IL6
3
Show member pathways
13.48 CXCL8 IL10 IL1A IL1B IL4 IL6
4
Show member pathways
13.43 CXCL8 FPR1 IL10 IL1A IL1B IL1RN
5
Show member pathways
13.37 CXCL8 IL10 IL1A IL1B IL4 IL6
6
Show member pathways
13.07 CXCL8 IL1A IL1B IL1RN IL6 TLR4
7
Show member pathways
12.96 CXCL8 IL10 IL1A IL1B IL4 IL6
8
Show member pathways
12.95 CXCL8 IL10 IL1B IL6 TLR4 TNF
9
Show member pathways
12.91 CXCL8 IL1A IL1B IL4 IL6 TLR4
10
Show member pathways
12.74 IL1A IL1B IL6 TLR4 TNF
11
Show member pathways
12.7 IL10 IL1A IL1B IL4 IL6 TLR4
12
Show member pathways
12.66 IL1A IL1B TLR4 TNF TNFSF11
13 12.65 IL10 IL1B IL1RN IL4 TNF TNFSF11
14
Show member pathways
12.55 IL10 IL1A IL1B IL4 IL6 TNF
15
Show member pathways
12.44 CXCL8 IL1B IL4 IL6 MMP1 TNF
16
Show member pathways
12.38 CXCL8 IL1A IL1B IL6 TLR4 TNF
17
Show member pathways
12.37 FCGR2A IL10 IL1A IL1B IL4 TLR4
18 12.34 FCGR2A IL10 IL1A IL1B IL6 TLR4
19
Show member pathways
12.3 CXCL8 IL1B IL4 IL6 TLR4 TNF
20 12.29 CXCL8 IL10 IL1A IL1B IL1RN IL6
21 12.23 IL6 MMP1 TLR4 TNF
22
Show member pathways
12.23 CXCL8 IL10 IL1A IL1B IL4 IL6
23 12.17 FCGR2A IL1A IL1B TNF TNFSF11
24 12.12 FCGR2A IL10 IL4 IL6 TNF
25
Show member pathways
12.08 IL10 IL1B IL6 TLR4 TNF
26 12.04 CXCL8 IL1A IL1B IL6 TNF
27 12.03 CXCL8 IL1A IL1B IL6
28 12.03 CXCL8 IL10 IL1B IL6 TLR4 TNF
29 12.02 IL1A IL1B IL4 IL6 TNF
30
Show member pathways
12.01 IL1B IL4 IL6 TLR4
31 12 CXCL8 IL1B TLR4 TNF TNFSF11
32 11.96 CXCL8 IL1A IL1B IL6 TLR4
33 11.94 CXCL8 FCGR2A IL1A IL1B IL4 IL6
34
Show member pathways
11.91 MMP1 MMP8 TNF
35 11.91 CXCL8 IL4 IL6 MMP1
36 11.89 IL10 IL1B IL4 TNF
37
Show member pathways
11.88 CXCL8 IL6 TLR4
38 11.87 IL10 IL1B IL6 TNF
39 11.85 FCGR2A IL10 IL4 IL6 TLR4 TNF
40 11.81 CXCL8 IL10 IL1A IL1B IL4 IL6
41 11.8 CXCL8 IL1B IL4 IL6 TNF
42
Show member pathways
11.79 CXCL8 IL4 TNF
43 11.79 CXCL8 IL10 IL1A IL1B IL6 TLR4
44
Show member pathways
11.77 CXCL8 IL1A IL1B IL6 MMP1 TNF
45 11.73 CXCL8 IL1B IL6 TLR4 TNF
46 11.65 FCGR2A FPR1 IL10
47 11.64 IL1A IL1B IL6 TNF TNFSF11
48 11.63 IL1A TLR4 TNF
49 11.62 CXCL8 IL10 IL1B IL6 TLR4 TNF
50 11.61 CXCL8 IL6 MMP1

GO Terms for Aggressive Periodontitis

Cellular components related to Aggressive Periodontitis according to GeneCards Suite gene sharing:

id Name GO ID Score Top Affiliating Genes
1 extracellular region GO:0005576 9.77 CTSC CXCL8 DEFB1 IL10 IL1A IL1B
2 external side of plasma membrane GO:0009897 9.46 IL4 IL6 TLR4 TNF
3 extracellular space GO:0005615 9.4 CTSC CXCL8 DEFB1 IL10 IL1A IL1B

Biological processes related to Aggressive Periodontitis according to GeneCards Suite gene sharing:

(show top 50) (show all 64)
id Name GO ID Score Top Affiliating Genes
1 response to lipopolysaccharide GO:0032496 9.99 IL10 IL1B IL6 TLR4
2 positive regulation of I-kappaB kinase/NF-kappaB signaling GO:0043123 9.97 IL1B TLR4 TNF TNFSF11
3 chemotaxis GO:0006935 9.96 CXCL8 DEFB1 FPR1 IL4
4 cytokine-mediated signaling pathway GO:0019221 9.94 IL1A IL1B IL6 TNFSF11
5 defense response to Gram-positive bacterium GO:0050830 9.9 DEFB1 IL6 TNF
6 response to organic substance GO:0010033 9.9 CTSC IL10 TNF
7 positive regulation of protein kinase B signaling GO:0051897 9.9 IL6 TNF TNFSF11
8 defense response to Gram-negative bacterium GO:0050829 9.89 DEFB1 IL6 TLR4
9 activation of MAPK activity GO:0000187 9.89 FPR1 IL1B TLR4 TNF
10 positive regulation of T cell proliferation GO:0042102 9.87 IL1B IL4 IL6
11 positive regulation of NF-kappaB transcription factor activity GO:0051092 9.85 IL1B IL6 TLR4 TNF TNFSF11
12 positive regulation of interferon-gamma production GO:0032729 9.83 IL1B TLR4 TNF
13 positive regulation of JNK cascade GO:0046330 9.83 IL1B TLR4 TNF TNFSF11
14 cellular response to lipopolysaccharide GO:0071222 9.83 CXCL8 IL10 IL6 TLR4 TNF
15 negative regulation of extrinsic apoptotic signaling pathway in absence of ligand GO:2001240 9.81 IL1A IL1B TNF
16 response to glucocorticoid GO:0051384 9.81 IL10 IL1RN IL6 TNF
17 response to bacterium GO:0009617 9.79 DEFB1 IL6 TLR4
18 extrinsic apoptotic signaling pathway in absence of ligand GO:0097192 9.79 IL1A IL1B IL4
19 lipopolysaccharide-mediated signaling pathway GO:0031663 9.78 IL1B TLR4 TNF
20 positive regulation of cytokine secretion GO:0050715 9.77 IL10 IL1A TNF
21 positive regulation of interleukin-8 production GO:0032757 9.76 IL1B TLR4 TNF
22 negative regulation of interleukin-6 production GO:0032715 9.75 IL10 TLR4 TNF
23 defense response to protozoan GO:0042832 9.74 IL10 IL4 IL6
24 regulation of osteoclast differentiation GO:0045670 9.73 TNF TNFSF11
25 cellular response to hepatocyte growth factor stimulus GO:0035729 9.73 IL10 IL6
26 acute inflammatory response GO:0002526 9.73 DEFB1 IL6
27 regulation of I-kappaB kinase/NF-kappaB signaling GO:0043122 9.73 IL1B TNF
28 positive regulation of NF-kappaB import into nucleus GO:0042346 9.73 IL1B TLR4 TNF
29 response to molecule of bacterial origin GO:0002237 9.72 CXCL8 IL10
30 positive regulation of interleukin-2 biosynthetic process GO:0045086 9.72 IL1A IL1B
31 negative regulation of heterotypic cell-cell adhesion GO:0034115 9.71 IL10 IL1RN
32 positive regulation of monocyte chemotactic protein-1 production GO:0071639 9.71 IL1A IL1B
33 negative regulation of lipid storage GO:0010888 9.71 IL6 TNF
34 positive regulation of interleukin-8 biosynthetic process GO:0045416 9.71 TLR4 TNF
35 positive regulation of chemokine production GO:0032722 9.71 IL6 TLR4 TNF
36 positive regulation of nitric oxide biosynthetic process GO:0045429 9.71 IL1B IL6 TLR4 TNF
37 endothelial cell apoptotic process GO:0072577 9.7 IL10 TNF
38 ectopic germ cell programmed cell death GO:0035234 9.7 IL1A IL1B
39 regulation of establishment of endothelial barrier GO:1903140 9.69 IL1B TNF
40 negative regulation of cytokine secretion involved in immune response GO:0002740 9.68 IL10 TNF
41 epithelial cell proliferation involved in salivary gland morphogenesis GO:0060664 9.68 IL6 TNF
42 type 2 immune response GO:0042092 9.68 IL10 IL4
43 positive regulation of fever generation GO:0031622 9.67 IL1B TNF
44 positive regulation of heterotypic cell-cell adhesion GO:0034116 9.67 IL10 IL1B TNF
45 sequestering of triglyceride GO:0030730 9.65 IL1B TNF
46 regulation of isotype switching GO:0045191 9.65 IL10 IL4
47 negative regulation of interleukin-1-mediated signaling pathway GO:2000660 9.65 IL1RN IL6
48 positive regulation of chemokine biosynthetic process GO:0045080 9.65 IL1B IL4 TNF
49 positive regulation of interleukin-6 production GO:0032755 9.65 IL1A IL1B IL6 TLR4 TNF
50 positive regulation of mononuclear cell migration GO:0071677 9.64 IL4 TNF

Molecular functions related to Aggressive Periodontitis according to GeneCards Suite gene sharing:

id Name GO ID Score Top Affiliating Genes
1 cytokine activity GO:0005125 9.28 CXCL8 IL10 IL1A IL1B IL1RN IL4
2 interleukin-1 receptor binding GO:0005149 9.13 IL1A IL1B IL1RN

Sources for Aggressive Periodontitis

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