MCID: AGG001
MIFTS: 50

Aggressive Periodontitis malady

Categories: Oral diseases

Aliases & Classifications for Aggressive Periodontitis

Aliases & Descriptions for Aggressive Periodontitis:

Name: Aggressive Periodontitis 12 42 14
Periodontitis, Juvenile 69
Juvenile Periodontitis 12

Classifications:



External Ids:

Disease Ontology 12 DOID:1474
ICD10 33 K05.2
MeSH 42 D010520
UMLS 69 C0031106

Summaries for Aggressive Periodontitis

Disease Ontology : 12 A periodontitis that is characterized by rapid attachment loss and bone destruction in the presence of little local factors such as dental plaque and dental calculus resulting in inflammation and a loss of periodontium.

MalaCards based summary : Aggressive Periodontitis, also known as periodontitis, juvenile, is related to amelogenesis imperfecta and rheumatoid arthritis. An important gene associated with Aggressive Periodontitis is IL1B (Interleukin 1 Beta), and among its related pathways/superpathways are Innate Immune System and PEDF Induced Signaling. The drugs Estradiol and Norgestimate have been mentioned in the context of this disorder. Affiliated tissues include bone, neutrophil and monocytes, and related phenotypes are hematopoietic system and homeostasis/metabolism

Wikipedia : 71 Aggressive periodontitis describes a type of periodontal disease and includes two of the seven... more...

Related Diseases for Aggressive Periodontitis

Diseases in the Aggressive Periodontitis family:

Periodontitis, Aggressive, 2

Diseases related to Aggressive Periodontitis via text searches within MalaCards or GeneCards Suite gene sharing:

(show top 50) (show all 275)
id Related Disease Score Top Affiliating Genes
1 amelogenesis imperfecta 29.8 CXCL8 IL10 IL6 TNF
2 rheumatoid arthritis 28.2 CXCL8 IL10 IL1A IL1B IL1RN IL4
3 histiocytosis 27.6 CTSC CXCL8 IL1A IL1B IL1RN IL6
4 susceptibility to localized juvenile periodontitis 11.9
5 periodontitis 1, juvenile 11.1
6 periodontitis 10.9
7 gingivitis 10.4
8 intussusception 10.4 IL1B TNF
9 pyridoxal 5'-phosphate-dependent epilepsy 10.3 IL10 TNF
10 cerebellar disease 10.3 IL1A IL1B TNF
11 vps11-related autosomal recessive hypomyelinating leukodystrophy 10.3 IL6 TNF
12 warthin tumor 10.3 IL1B IL1RN TNF
13 bipolar i disorder 10.3 IL1B IL6 TNF
14 swine influenza 10.3 IL1A IL6 TNF
15 human immunodeficiency virus infectious disease 10.3 IL1B IL6 TNF
16 mental retardation hypotonia skin hyperpigmentation 10.3 IL1A IL1B IL1RN
17 sarcomatoid transitional cell carcinoma 10.3 IL10 IL1A TNF
18 tinea capitis 10.3 IL1B IL6 TNF
19 measles 10.3 IL1B IL6 TNF
20 transient tic disorder 10.3 IL10 IL6 TNF
21 tubular renal disease-cardiomyopathy syndrome 10.3 IL10 IL4 TNF
22 lagophthalmos 10.3 IL10 IL4 TNF
23 mineral metabolism disease 10.3 IL1B IL6 TNF
24 migraine with aura 10.3 IL1B IL6 TNF
25 cyclosporiasis 10.3 IL10 IL6 TNF
26 oral cavity carcinoma in situ 10.3 IL10 IL1B IL1RN
27 hypotrichosis 4 10.3 IL1A IL4 TNF
28 phlyctenulosis 10.2 IL10 IL6 TNF
29 vestibule of mouth cancer 10.2 IL10 IL4 TNF
30 conduct disorder 10.2 IL10 IL6 TNF
31 urea cycle disorder 10.2 IL10 IL1B IL6
32 splenic artery aneurysm 10.2 IL1B IL6 TNF
33 pancreatic signet ring cell adenocarcinoma 10.2 IL10 IL6 TNF
34 stickler syndrome, type v 10.2 IL1A IL1B IL6
35 hereditary alpha tryptasemia syndrome 10.2 IL10 IL6 TNF
36 osteodysplasty precocious of danks mayne and kozlowski 10.2 IL10 IL4 TNF
37 hepatitis 10.2 IL10 IL6 TNF
38 pancreas lymphoma 10.2 IL1B IL6 TNF
39 congenital hypothyroidism 10.2 IL10 IL4 TNF
40 microglandular adenosis of breast 10.2 CXCL8 IL10 IL1A
41 amyotrophic lateral sclerosis type 14 10.2 CXCL8 IL1B TNF
42 oculomotor nerve paralysis 10.2 CXCL8 IL1B IL6
43 common peroneal nerve lesion 10.2 CXCL8 IL1B IL6
44 clostridium difficile colitis 10.2 IL4 IL6 TNF
45 plummer's disease 10.2 IL10 IL6 TNF
46 tularemia 10.2 IL10 IL4 TNF
47 breast reconstruction 10.2 IL10 IL1B IL6
48 disease of mental health 10.2 IL10 IL6 TNF
49 plantar wart 10.2 CXCL8 IL10 TNF
50 coenurosis 10.2 IL1B IL4 IL6

Graphical network of the top 20 diseases related to Aggressive Periodontitis:



Diseases related to Aggressive Periodontitis

Symptoms & Phenotypes for Aggressive Periodontitis

MGI Mouse Phenotypes related to Aggressive Periodontitis:

44
id Description MGI Source Accession Score Top Affiliating Genes
1 hematopoietic system MP:0005397 10.15 FPR1 IL10 IL1A IL1B IL1RN IL4
2 homeostasis/metabolism MP:0005376 10.13 TNF TNFSF11 CTSC FPR1 IL10 IL1A
3 immune system MP:0005387 10.1 IL1RN IL4 IL6 MMP1 MMP8 TLR4
4 integument MP:0010771 9.85 CTSC IL10 IL1A IL1B IL1RN IL4
5 neoplasm MP:0002006 9.61 IL10 IL1A IL1B IL6 MMP1 MMP8
6 skeleton MP:0005390 9.28 FCGR2A IL10 IL1B IL1RN IL4 IL6

Drugs & Therapeutics for Aggressive Periodontitis

Drugs for Aggressive Periodontitis (from DrugBank, HMDB, Dgidb, PharmGKB, IUPHAR, NovoSeek, BitterDB):

(show top 50) (show all 57)
id Name Status Phase Clinical Trials Cas Number PubChem Id
1
Estradiol Approved, Investigational, Vet_approved Phase 4 50-28-2 5757 53477783
2
Norgestimate Approved Phase 4 35189-28-7 6540478
3
Amoxicillin Approved, Vet_approved Phase 4,Phase 2,Phase 3 26787-78-0 33613 2171
4
Metronidazole Approved Phase 4,Phase 2,Phase 3 443-48-1 4173
5
Moxifloxacin Approved, Investigational Phase 4 354812-41-2, 151096-09-2 152946
6
Chlorhexidine Approved, Vet_approved Phase 4 55-56-1 9552079 2713
7
Ethinyl Estradiol Approved Phase 4 57-63-6 5991
8 Chlorhexidine gluconate Phase 4
9 Estradiol valerate Phase 4 979-32-8
10 Contraceptive Agents Phase 4
11 Contraceptives, Oral Phase 4
12 Contraceptives, Oral, Combined Phase 4
13 Norgestimate, ethinyl estradiol drug combination Phase 4
14 Topoisomerase Inhibitors Phase 4
15 Nucleic Acid Synthesis Inhibitors Phase 4
16 Estradiol 17 beta-cypionate Phase 4
17 Estradiol 3-benzoate Phase 4
18 Anti-Bacterial Agents Phase 4,Phase 2,Phase 3
19 Polyestradiol phosphate Phase 4
20 Anti-Infective Agents Phase 4,Phase 2,Phase 3
21 Fluoroquinolones Phase 4
22 Antibiotics, Antitubercular Phase 4,Phase 2,Phase 3
23 Antiparasitic Agents Phase 4,Phase 2,Phase 3
24 Antiprotozoal Agents Phase 4,Phase 2,Phase 3
25 Anesthetics Phase 4
26 Anesthetics, Local Phase 4
27
Clarithromycin Approved Phase 2, Phase 3 81103-11-9 84029
28
Aspirin Approved, Vet_approved Phase 2, Phase 3 50-78-2 2244
29 Cytochrome P-450 CYP3A Inhibitors Phase 2, Phase 3
30 Cytochrome P-450 Enzyme Inhibitors Phase 2, Phase 3
31 Analgesics Phase 2, Phase 3
32 Cyclooxygenase Inhibitors Phase 2, Phase 3
33 Analgesics, Non-Narcotic Phase 2, Phase 3
34 Peripheral Nervous System Agents Phase 2, Phase 3
35 Platelet Aggregation Inhibitors Phase 2, Phase 3
36 Fibrinolytic Agents Phase 2, Phase 3
37 Anti-Inflammatory Agents Phase 2, Phase 3
38 Anti-Inflammatory Agents, Non-Steroidal Phase 2, Phase 3
39 Antipyretics Phase 2, Phase 3
40 Antirheumatic Agents Phase 2, Phase 3
41 Omega 3 Fatty Acid Nutraceutical Phase 2, Phase 3
42
Nitric Oxide Approved 10102-43-9 145068
43
Ergocalciferol Approved, Nutraceutical 50-14-6 5280793
44 vitamin d
45 Trace Elements
46 Dihydroxycholecalciferols
47 Ergocalciferols
48 Vitamins
49 Micronutrients
50 Bone Density Conservation Agents

Interventional clinical trials:

(show all 36)
id Name Status NCT ID Phase
1 Adjunctive Systemic Administration of Moxifloxacin in the Treatment of Aggressive Periodontitis Completed NCT02125812 Phase 4
2 Evaluation of Efficacy of Full-mouth Disinfection in Generalized Aggressive Periodontitis Patients Completed NCT02466646 Phase 4
3 Treatment of Aggressive Periodontitis With Repeated Adjunctive Antimicrobial Photodynamic Therapy Completed NCT02049008 Phase 4
4 Host Modulatory Effects of β-glucan on Localized Aggressive Periodontitis Completed NCT02402296 Phase 4
5 Alternative Antibiotic Regime in the Treatment of GAgP Completed NCT02223702 Phase 4
6 Effects of the Variation in the Time of Systemic Administration of Metronidazole and Amoxicillin Associated to the Non-surgical Therapy of Chronic Periodontitis. Completed NCT01211223 Phase 4
7 Antimicrobial Therapy as Adjunct to Periodontal Treatment: Effect of Timing Completed NCT02197260 Phase 4
8 Efficacy of Three Antibiotic Protocols for Aggressive Periodontitis Treatment Recruiting NCT02839421 Phase 4
9 Enamel Matrix Proteins in the Treatment of Intrabony Defects in Patients With Aggressive and Chronic Periodontitis Recruiting NCT03025204 Phase 4
10 Two Different Antibiotic Agents to Treat Generalized Aggressive Periodontitis Completed NCT02969928 Phase 2, Phase 3
11 Periodontal Debridement Associated With Systemic Antibiotics and Single/Repeated PDT to Treat Aggressive Periodontitis Completed NCT03132714 Phase 2, Phase 3
12 Omega-3 Plus Low-dose Aspirin Daily Supplementation in Non-surgical Therapy to Treat Aggressive Periodontitis Recruiting NCT03093246 Phase 2, Phase 3
13 Omega-3 Fatty Acids Plus Low-dose Aspirin Daily Supplementation in Surgical Therapy to Treat Aggressive Periodontitis Recruiting NCT03093207 Phase 2, Phase 3
14 The Affect of Orthodontic Treatment on the Periodontal Status of Patients With Aggressive Periodontitis Unknown status NCT01510808
15 Polymorphonuclear Cells' Sensitivity to Aggregatibacter Actinomycetemcomitans Bacteria in Patients With Aggressive Periodontitis Unknown status NCT02010307
16 Chronic Presence of Epstein Barr Virus in Epithelial Cells From Gingiva is Associated With Periodontitis Unknown status NCT01246596
17 Chronic Presence of Epstein Barr Virus in Sulcular and Junctional Epithelial Tissue From Gingiva is Associated With Severe Periodontitis Unknown status NCT01246648
18 Immunolocalization of 1,25,Dihydroxyvitamin D3 in Aggressive Periodontitis Patients Completed NCT02282800
19 Gene Expression Profiles in Generalized Aggressive Periodontitis: A Gene Network-based Microarray Analysis Completed NCT02327533 Early Phase 1
20 Gingival Crevicular Fluid Levels Of Monocyte Chemoattractant Protein-1 Completed NCT02927704
21 Frequency Of MCP-1 And CCR2 Gene Polymorphisms And Its Effect On Gene Expression In Patients With AgP Completed NCT02817568
22 Effects of Er,Cr:YSGG, Diode Lasers on GCF Cytokines Levels Completed NCT03034824
23 Clarithromycin as Adjuvant to Periodontal Debridement Completed NCT02829983
24 Smoking Influence on Apoptosis in Periodontitis Completed NCT02111005
25 Nonsurgical Periodontal Treatment Associated or Not With Systemic Antibiotics and Photodynamic Therapy Completed NCT03142776
26 Estimation of Pentrexin-3 Levels in GCF and Saliva of Patients With Periodontal Disease Completed NCT03128502
27 Effect of Surgical Therapy on RANKL/OPG (Osteoprotegerin) System Completed NCT02190773
28 Nitro-oxidative Stress in Periodontitis Completed NCT02127203
29 The Importance of Periostin in Periodontal Health and Disease Completed NCT01180920
30 Mechanisms and Treatment Response of Aggressive Periodontitis in Children Recruiting NCT01330719
31 Subgingival Microbiome Following Mechanical Treatment and it's Effect on Peri-implant Sub-mucosa in Aggressive Periodontitis Patients Recruiting NCT03090282
32 Analysis of Osteoimmune Interactions Linking Inflammation and Bone Destruction in Aggressive Periodontitis Recruiting NCT01993368
33 B Cell Functions in Periodontitis Recruiting NCT02833285
34 Gingival Bleeding and Von Willebrand Disease Typ 2 and 3 Recruiting NCT03078595
35 Comparison Between Surgical Access and Repeated Applications of APDT Active, not recruiting NCT03140059
36 Long-term Results After Systematic Periodontal Therapy Enrolling by invitation NCT03048045

Search NIH Clinical Center for Aggressive Periodontitis

Cochrane evidence based reviews: aggressive periodontitis

Genetic Tests for Aggressive Periodontitis

Anatomical Context for Aggressive Periodontitis

MalaCards organs/tissues related to Aggressive Periodontitis:

39
Bone, Neutrophil, Monocytes, Whole Blood, Colon, T Cells

Publications for Aggressive Periodontitis

Articles related to Aggressive Periodontitis:

(show top 50) (show all 552)
id Title Authors Year
1
IL-6 and IL-10 gene polymorphisms in patients with aggressive periodontitis: effects on GCF, serum and clinic parameters. ( 28099578 )
2017
2
Treatment compliance in patients with aggressive periodontitis - a retrospective case-control study. ( 27899029 )
2017
3
Treatment of a Periodontic-Endodontic Lesion in a Patient with Aggressive Periodontitis. ( 27418983 )
2016
4
Peri-implant and periodontal microbiome diversity in aggressive periodontitis patients: a pilot study. ( 27170047 )
2016
5
Width of Keratinized Mucosa at Implant Sites in Patients Treated for Generalized Aggressive Periodontitis: A Cohort Study. ( 27004285 )
2016
6
Platelet activation and platelet-leukocyte interaction in generalized aggressive periodontitis. ( 27334227 )
2016
7
Gingival Crevicular Fluid and Saliva Stress Hormone Levels in Patients with Chronic and Aggressive Periodontitis. ( 27513682 )
2016
8
Lack of association between the TNF-I+-1031genotypes and generalized aggressive periodontitis disease. ( 27755954 )
2016
9
Trends in Susceptibility to Aggressive Periodontal Disease. ( 28008419 )
2016
10
Tooth loss and alveolar bone crest loss during supportive periodontal therapy in patients with generalized aggressive periodontitis: retrospective study with follow-up of 8 to 15 years. ( 27396322 )
2016
11
Differentiation of Chronic and Aggressive Periodontitis by FTIR Spectroscopy. ( 27608648 )
2016
12
Periodontal Surgery Involving Modified Widman Flap Procedure and Connective Tissue Graft for Generalized Aggressive Periodontitis: A Case Report. ( 28049974 )
2016
13
The role of platelets in inflammatory immune responses in generalized aggressive periodontitis. ( 27883202 )
2016
14
Gingival crevicular fluid and serum hCAP18/LL-37 levels in generalized aggressive periodontitis. ( 27129587 )
2016
15
A Putative Association of a Single Nucleotide Polymorphism in GPR126 with Aggressive Periodontitis in a Japanese Population. ( 27509131 )
2016
16
Inflammatory Response Influences Treatment of Localized Aggressive Periodontitis. ( 26917438 )
2016
17
Gingival Crevicular Fluid and Salivary Periostin Levels in Non-Smoker Subjects With Chronic and Aggressive Periodontitis : Periostin Levels in Chronic and Aggressive Periodontitis. ( 26931107 )
2016
18
Efficacy of Photodynamic Therapy and Lasers as an Adjunct to Scaling and Root Planing in the Treatment of Aggressive Periodontitis - A Clinical and Microbiologic Short Term Study. ( 27042576 )
2016
19
Antibiotics in aggressive periodontitis, is there a clinical benefit? ( 27980332 )
2016
20
Adjunct Antimicrobial Therapy and Periodontal Surgery to Treat Generalized Aggressive Periodontitis: A Case Report. ( 27320300 )
2016
21
Analysis of polymorphisms in Interleukin 10, NOS2A, and ESR2 genes in chronic and aggressive periodontitis. ( 27737359 )
2016
22
Detection and comparison of Selenomonas sputigena in subgingival biofilms in chronic and aggressive periodontitis patients. ( 27563202 )
2016
23
The microbial community shifts of subgingival plaque in patients with generalized aggressive periodontitis following non-surgical periodontal therapy: a pilot study. ( 27732961 )
2016
24
Predictors of clinical outcomes after periodontal treatment of aggressive periodontitis: 12-month randomized trial. ( 27223128 )
2016
25
Detection of Porphyromonas gingivalis and Treponema denticola in chronic and aggressive periodontitis patients: A comparative polymerase chain reaction study. ( 27994415 )
2016
26
Nonsyndromic localized aggressive periodontitis of primary dentition: A rare case report. ( 27307682 )
2016
27
Clinical and Immunoinflamatory Evaluation of One Stage Full-Mouth Ultrassonic Debridement as a Therapeutic Approach for Smokers With Generalized Aggressive Periodontitis: A Short-Term Follow-up Study. ( 27177288 )
2016
28
GC Gene Polymorphisms and Vitamin D-Binding Protein Levels Are Related to the Risk of Generalized Aggressive Periodontitis. ( 28018430 )
2016
29
Periodontal regeneration with 0.3% basic fibroblast growth factor (FGF-2) for a patient with aggressive periodontitis: a case report. ( 27021551 )
2016
30
Disease progression in aggressive periodontitis patients. A Retrospective Study. ( 26878438 )
2016
31
Periodontal regeneration in aggressive periodontitis patients: A systematic review of the literature. ( 27778470 )
2016
32
Outcomes of implant therapy in patients with a history of aggressive periodontitis. A systematic review and meta-analysis. ( 28013438 )
2016
33
Association of Interleukin-17 polymorphism (-197G/A) in chronic and localized aggressive periodontitis. ( 26910014 )
2016
34
Effect of patient age awareness on diagnostic agreement of chronic or aggressive periodontitis between clinicians; a pilot study. ( 27456238 )
2016
35
Gingival Inflammation and Aggressive Periodontitis in a Child with a Specific Antibody Deficiency. ( 27188128 )
2016
36
Porphyromonas gingivalis-induced production of reactive oxygen species, tumor necrosis factor-I+, interleukin-6, CXCL8 and CCL2 by neutrophils from localized aggressive periodontitis and healthy donors: modulating actions of red blood cells and resolvin E1. ( 27146665 )
2016
37
Langerhans cell histiocytosis mimicking aggressive periodontitis: Challenges in diagnosis and management. ( 27447001 )
2016
38
Total and Differential Leukocyte Counts in the Peripheral Blood of Patients with Generalised Aggressive Periodontitis. ( 27351735 )
2016
39
Localized Aggressive Periodontitis Immune Response to Healthy and Diseased Subgingival Plaque. ( 27037664 )
2016
40
Tumor necrosis factor-I+ G-308A (rs1800629) polymorphism and aggressive periodontitis susceptibility: a meta-analysis of 16 case-control studies. ( 26750615 )
2016
41
Is there a common pathogenesis in aggressive periodontitis & ankylosing spondylitis in HLA-B27 patient? ( 27063088 )
2016
42
Long-term clinical response to treatment and maintenance of localized aggressive periodontitis: a cohort study. ( 27767222 )
2016
43
Epigenetic characteristics in inflammatory candidate genes in aggressive periodontitis. ( 26472015 )
2016
44
Bacterial profile of aggressive periodontitis in Morocco: a cross-sectional study. ( 25888404 )
2015
45
Localized aggressive periodontitis treatment response in primary and permanent dentitions. ( 25812885 )
2015
46
Effect of Surgical Periodontal Therapy on Serum C-reactive Protein Levels Using ELISA in Both Chronic and Aggressive Periodontitis Patient. ( 26557605 )
2015
47
Congenital adrenal hyperplasia with localized aggressive periodontitis and amelogenesis imperfecta. ( 26191638 )
2015
48
Association between Interleukin-1I^ Gene -511C>T/+3954C>T Polymorphisms and Aggressive Periodontitis Susceptibility: Evidence from a Meta-Analysis. ( 26038188 )
2015
49
Association between Manganese Superoxide Dismutase (MnSOD Val-9Ala) genotypes with the risk of generalized aggressive periodontitis disease. ( 26718428 )
2015
50
Comparison of salivary calcium level in smokers and non-smokers with chronic periodontitis, aggressive periodontitis, and healthy controls. ( 26942120 )
2015

Variations for Aggressive Periodontitis

Expression for Aggressive Periodontitis

Search GEO for disease gene expression data for Aggressive Periodontitis.

Pathways for Aggressive Periodontitis

Pathways related to Aggressive Periodontitis according to GeneCards Suite gene sharing:

(show top 50) (show all 69)
id Super pathways Score Top Affiliating Genes
1
Show member pathways
14.03 CTSC CXCL8 FCGR2A FPR1 IL10 IL1A
2
Show member pathways
13.7 CXCL8 IL10 IL1A IL1B IL4 IL6
3
Show member pathways
13.48 CXCL8 IL10 IL1A IL1B IL4 IL6
4
Show member pathways
13.43 CXCL8 FPR1 IL10 IL1A IL1B IL1RN
5
Show member pathways
13.37 CXCL8 IL10 IL1A IL1B IL4 IL6
6
Show member pathways
13.07 CXCL8 IL1A IL1B IL1RN IL6 TLR4
7
Show member pathways
12.97 CXCL8 IL10 IL1B IL6 TLR4 TNF
8
Show member pathways
12.96 CXCL8 IL10 IL1A IL1B IL4 IL6
9
Show member pathways
12.9 CXCL8 IL1A IL1B IL4 IL6 TLR4
10
Show member pathways
12.74 IL1A IL1B IL6 TLR4 TNF
11
Show member pathways
12.7 IL10 IL1A IL1B IL4 IL6 TLR4
12
Show member pathways
12.66 IL1A IL1B TLR4 TNF TNFSF11
13 12.65 IL10 IL1B IL1RN IL4 TNF TNFSF11
14
Show member pathways
12.55 IL10 IL1A IL1B IL4 IL6 TNF
15
Show member pathways
12.44 CXCL8 IL1B IL4 IL6 MMP1 TNF
16
Show member pathways
12.38 CXCL8 IL1A IL1B IL6 TLR4 TNF
17
Show member pathways
12.37 IL1B IL4 IL6 TNF
18
Show member pathways
12.36 CXCL8 IL1A IL6 TLR4 TNF
19
Show member pathways
12.36 FCGR2A IL10 IL1A IL1B IL4 TLR4
20 12.33 FCGR2A IL10 IL1A IL1B IL6 TLR4
21
Show member pathways
12.3 CXCL8 IL1B IL4 IL6 TLR4 TNF
22 12.28 CXCL8 IL10 IL1A IL1B IL1RN IL6
23 12.24 IL6 MMP1 TLR4 TNF
24
Show member pathways
12.23 CXCL8 IL10 IL1A IL1B IL4 IL6
25 12.17 FCGR2A IL1A IL1B TNF TNFSF11
26 12.12 FCGR2A IL10 IL4 IL6 TNF
27
Show member pathways
12.08 IL10 IL1B IL6 TLR4 TNF
28 12.04 CXCL8 IL1A IL1B IL6 TNF
29 12.03 CXCL8 IL1A IL1B IL6
30 12.03 CXCL8 IL10 IL1B IL6 TLR4 TNF
31 12.02 IL1A IL1B IL4 IL6 TNF
32
Show member pathways
12.01 IL1B IL4 IL6 TLR4
33 12.01 CXCL8 IL1B TLR4 TNF TNFSF11
34 11.96 CXCL8 IL1A IL1B IL6 TLR4
35 11.95 IL1B IL6 TNF
36 11.94 CXCL8 FCGR2A IL1A IL1B IL4 IL6
37
Show member pathways
11.91 MMP1 MMP8 TNF
38 11.91 CXCL8 IL4 IL6 MMP1
39 11.9 IL10 IL1B IL4 TNF
40
Show member pathways
11.88 CXCL8 IL6 TLR4
41 11.87 IL10 IL1B IL6 TNF
42 11.83 FCGR2A IL10 IL4 IL6 TLR4 TNF
43 11.81 CXCL8 IL10 IL1A IL1B IL4 IL6
44 11.8 CXCL8 IL1B IL4 IL6 TNF
45
Show member pathways
11.79 CXCL8 IL4 TNF
46 11.79 CXCL8 IL10 IL1A IL1B IL6 TLR4
47
Show member pathways
11.77 CXCL8 IL1A IL1B IL6 MMP1 TNF
48 11.73 CXCL8 IL1B IL6 TLR4 TNF
49 11.65 FCGR2A FPR1 IL10
50 11.64 IL1A TLR4 TNF

GO Terms for Aggressive Periodontitis

Cellular components related to Aggressive Periodontitis according to GeneCards Suite gene sharing:

id Name GO ID Score Top Affiliating Genes
1 extracellular region GO:0005576 9.73 CTSC CXCL8 IL10 IL1A IL1B IL1RN
2 external side of plasma membrane GO:0009897 9.46 IL4 IL6 TLR4 TNF
3 extracellular space GO:0005615 9.36 CTSC CXCL8 IL10 IL1A IL1B IL1RN

Biological processes related to Aggressive Periodontitis according to GeneCards Suite gene sharing:

(show top 50) (show all 60)
id Name GO ID Score Top Affiliating Genes
1 leukocyte migration GO:0050900 9.99 FPR1 IL1B MMP1 TNF
2 response to lipopolysaccharide GO:0032496 9.98 IL10 IL1B IL6 TLR4
3 positive regulation of I-kappaB kinase/NF-kappaB signaling GO:0043123 9.96 IL1B TLR4 TNF TNFSF11
4 cytokine-mediated signaling pathway GO:0019221 9.94 IL1A IL1B IL6 TNFSF11
5 response to organic substance GO:0010033 9.89 CTSC IL10 TNF
6 positive regulation of protein kinase B signaling GO:0051897 9.88 IL6 TNF TNFSF11
7 activation of MAPK activity GO:0000187 9.88 FPR1 IL1B TLR4 TNF
8 positive regulation of T cell proliferation GO:0042102 9.86 IL1B IL4 IL6
9 positive regulation of interferon-gamma production GO:0032729 9.83 IL1B TLR4 TNF
10 response to glucocorticoid GO:0051384 9.83 IL10 IL1RN IL6 TNF
11 positive regulation of NF-kappaB transcription factor activity GO:0051092 9.83 IL1B IL6 TLR4 TNF TNFSF11
12 positive regulation of JNK cascade GO:0046330 9.81 IL1B TLR4 TNF TNFSF11
13 negative regulation of extrinsic apoptotic signaling pathway in absence of ligand GO:2001240 9.8 IL1A IL1B TNF
14 lipopolysaccharide-mediated signaling pathway GO:0031663 9.78 IL1B TLR4 TNF
15 extrinsic apoptotic signaling pathway in absence of ligand GO:0097192 9.77 IL1A IL1B IL4
16 positive regulation of cytokine secretion GO:0050715 9.77 IL10 IL1A TNF
17 positive regulation of interleukin-8 production GO:0032757 9.75 IL1B TLR4 TNF
18 negative regulation of interleukin-6 production GO:0032715 9.74 IL10 TLR4 TNF
19 negative regulation of growth of symbiont in host GO:0044130 9.73 IL10 TNF
20 regulation of osteoclast differentiation GO:0045670 9.73 TNF TNFSF11
21 positive regulation of NF-kappaB import into nucleus GO:0042346 9.73 IL1B TLR4 TNF
22 positive regulation of membrane protein ectodomain proteolysis GO:0051044 9.72 IL1B TNF
23 cellular response to hepatocyte growth factor stimulus GO:0035729 9.72 IL10 IL6
24 regulation of I-kappaB kinase/NF-kappaB signaling GO:0043122 9.72 IL1B TNF
25 defense response to protozoan GO:0042832 9.72 IL10 IL4 IL6
26 cellular response to lipopolysaccharide GO:0071222 9.72 CXCL8 IL10 IL6 TLR4 TNF
27 negative regulation of nitric oxide biosynthetic process GO:0045019 9.71 IL10 IL4
28 response to molecule of bacterial origin GO:0002237 9.71 CXCL8 IL10
29 positive regulation of interleukin-2 biosynthetic process GO:0045086 9.71 IL1A IL1B
30 negative regulation of lipid storage GO:0010888 9.71 IL6 TNF
31 positive regulation of chemokine production GO:0032722 9.71 IL6 TLR4 TNF
32 negative regulation of heterotypic cell-cell adhesion GO:0034115 9.7 IL10 IL1RN
33 positive regulation of interleukin-8 biosynthetic process GO:0045416 9.7 TLR4 TNF
34 positive regulation of monocyte chemotactic protein-1 production GO:0071639 9.7 IL1A IL1B
35 endothelial cell apoptotic process GO:0072577 9.7 IL10 TNF
36 ectopic germ cell programmed cell death GO:0035234 9.69 IL1A IL1B
37 regulation of establishment of endothelial barrier GO:1903140 9.68 IL1B TNF
38 negative regulation of cytokine secretion involved in immune response GO:0002740 9.68 IL10 TNF
39 epithelial cell proliferation involved in salivary gland morphogenesis GO:0060664 9.68 IL6 TNF
40 type 2 immune response GO:0042092 9.67 IL10 IL4
41 positive regulation of fever generation GO:0031622 9.67 IL1B TNF
42 positive regulation of nitric oxide biosynthetic process GO:0045429 9.67 IL1B IL6 TLR4 TNF
43 sequestering of triglyceride GO:0030730 9.65 IL1B TNF
44 regulation of isotype switching GO:0045191 9.65 IL10 IL4
45 negative regulation of interleukin-1-mediated signaling pathway GO:2000660 9.65 IL1RN IL6
46 positive regulation of heterotypic cell-cell adhesion GO:0034116 9.65 IL10 IL1B TNF
47 positive regulation of interleukin-6 production GO:0032755 9.65 IL1A IL1B IL6 TLR4 TNF
48 positive regulation of mononuclear cell migration GO:0071677 9.64 IL4 TNF
49 positive regulation of chemokine biosynthetic process GO:0045080 9.63 IL1B IL4 TNF
50 positive regulation of sequence-specific DNA binding transcription factor activity GO:0051091 9.63 IL10 IL1B IL4 IL6 TNF TNFSF11

Molecular functions related to Aggressive Periodontitis according to GeneCards Suite gene sharing:

id Name GO ID Score Top Affiliating Genes
1 cytokine activity GO:0005125 9.28 CXCL8 IL10 IL1A IL1B IL1RN IL4
2 interleukin-1 receptor binding GO:0005149 9.13 IL1A IL1B IL1RN

Sources for Aggressive Periodontitis

3 CDC
7 CNVD
9 Cosmic
10 dbSNP
11 DGIdb
16 ExPASy
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