MCID: AGG001
MIFTS: 47

Aggressive Periodontitis malady

Oral diseases category
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Summaries for Aggressive Periodontitis

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Disease Ontology:8 A periodontitis that is characterized by rapid attachment loss and bone destruction in the presence of little local factors such as dental plaque and dental calculus resulting in inflammation and a loss of periodontium.

MalaCards based summary: Aggressive Periodontitis, also known as periodontitis, juvenile, is related to periodontitis and gingivitis. An important gene associated with Aggressive Periodontitis is FCGR3B (Fc fragment of IgG, low affinity IIIb, receptor (CD16b)), and among its related pathways are Fc-GammaR Pathway and Tuberculosis. The compounds tositumomab and ibritumomab have been mentioned in the context of this disorder. Affiliated tissues include bone, neutrophil and monocytes, and related mouse phenotypes are hematopoietic system and immune system.

Wikipedia:65 Aggressive periodontitis describes a type of periodontal disease and includes two of the seven... more...

Descriptions from OMIM:46 170650,608526

Aliases & Classifications for Aggressive Periodontitis

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Sources:
8Disease Ontology, 10DISEASES, 62UMLS, 44Novoseek, 57SNOMED-CT, 34MeSH, 46OMIM
See all sources

Aggressive Periodontitis, Aliases & Descriptions:

Name: Aggressive Periodontitis 8 10 62
Periodontitis, Juvenile 62
 
Periodontitis Juvenile 44
Juvenile Periodontitis 8


Classifications:

Malacards categories (disease lists): (See all malacards categories)
Anatomical: Oral diseases


External Ids:

Disease Ontology8 DOID:1474
MeSH34 D010520
SNOMED-CT57 2624008, 49965002

Related Diseases for Aggressive Periodontitis

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Diseases in the Aggressive Periodontitis family:

Periodontitis, Aggressive, 2

Diseases related to Aggressive Periodontitis via text searches within MalaCards or GeneCards/GeneDecks gene sharing:

(show all 40)
idRelated DiseaseScoreTop Affiliating Genes
1periodontitis32.1IL1A, MMP8, DEFB1
2gingivitis31.5IL1A, MMP8
3periodontal disease30.8DEFB1, MMP8, IL1A
4arthritis30.4FCGR2A, FCGR3B, MMP8, IL1A
5rheumatoid arthritis30.2FCGR2A, FCGR3B, MMP8, IL1A
6sarcoidosis30.1IL1A, DEFB1
7periodontosis10.7
8fibromatosis10.4
9tonsillitis10.4IL1A
10malaria10.4FCGR2A
11diabetes mellitus10.3
12type 1 diabetes mellitus10.3
13periapical granuloma10.3MMP8
14periodontitis 1, juvenile10.2
15blindness10.2
16neutropenia10.2FPR1, FCGR3B
17peritonitis10.1MMP8, FCGR3B
18nephritis10.1FCGR2A, FCGR3B
19systemic lupus erythematosus10.1FCGR3B, FCGR2A
20amelogenesis imperfecta10.1
21ectodermal dysplasia10.1
22fanconi's anemia10.1
23giant cell reparative granuloma10.1
24cutaneous lupus erythematosus10.1
25rickets10.1
26dental caries10.1
27lupus erythematosus10.1
28dentinogenesis imperfecta10.1
29tooth agenesis10.1
30pierre robin sequence10.1
31pustulosis palmaris et plantaris10.1
32synovitis10.0IL1A, MMP8
33cholesteatoma10.0IL1A, MMP8, DEFB1
34hypersensitivity reaction type ii disease10.0FCGR2A, FCGR3B, IL1A
35osteoarthritis10.0FCGR3B, MMP8, IL1A
36leukemia9.9FPR1, IL1A, FCGR3B, CYBA
37ipex syndrome9.9FPR1, MMP8, FCGR3B, FCGR2A
38sepsis9.8DEFB1, FCGR2A, FCGR3B, IL1A, FPR1
39atherosclerosis9.7CYBA, FCGR2A, MMP8, IL1A
40asthma9.7DEFB1, FCGR3B, FCER1A, MMP8

Graphical network of the top 20 diseases related to Aggressive Periodontitis:



Diseases related to aggressive periodontitis

Symptoms for Aggressive Periodontitis

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Clinical features from OMIM:

170650,608526

Drugs & Therapeutics for Aggressive Periodontitis

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Drug clinical trials:

Search ClinicalTrials for Aggressive Periodontitis

Search NIH Clinical Center for Aggressive Periodontitis

Genetic Tests for Aggressive Periodontitis

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Anatomical Context for Aggressive Periodontitis

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MalaCards organs/tissues related to Aggressive Periodontitis:

32
Bone, Neutrophil, Monocytes, Whole blood, Colon, T cells

Animal Models for Aggressive Periodontitis or affiliated genes

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MGI Mouse Phenotypes related to Aggressive Periodontitis:

36
idDescriptionMGI Source AccessionScoreTop Affiliating Genes
1MP:00053977.9FPR1, IL1A, FCER1A, FCGR2A, CYBA
2MP:00053876.7FPR1, DEFB1, CYBA, FCGR2A, FCER1A, MMP8

Publications for Aggressive Periodontitis

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Articles related to Aggressive Periodontitis:

(show top 50)    (show all 469)
idTitleAuthorsYear
1
The novel role of HtrA1 in gingivitis, chronic and aggressive periodontitis. (24979214)
2014
2
Investigation of dental pulp stem cells isolated from discarded human teeth extracted due to aggressive periodontitis. (25172527)
2014
3
Clinical and Microbiological Effects of Photodynamic Therapy Associated with Non-surgical Treatment in Aggressive Periodontitis. (25346834)
2014
4
Clinical and radiographic evaluation of intra-bony defects in localized aggressive periodontitis patients with platelet rich plasma/hydroxyapatite graft: A comparative controlled clinical trial. (25395757)
2014
5
Correlation of Aggregatibacter actinomycetemcomitans Detection with Clinical/Immunoinflammatory Profile of Localized Aggressive Periodontitis Using a 16S rRNA Microarray Method: A Cross-Sectional Study. (24376864)
2013
6
Bimaxillary unilateral gingival fibromatosis with localized aggressive periodontitis (eating the tooth at the same table). (24124307)
2013
7
Aggressive periodontitis diagnosed during or before orthodontic treatment. (23210838)
2013
8
Template-guided flapless implant insertion and prosthetic rehabilitation with telescopic crowns in a patient with treated generalized aggressive periodontitis: a case report. (22299117)
2012
9
Generalized aggressive periodontitis and its treatment options: case reports and review of the literature. (22291715)
2012
10
Microbiological characterization in children with aggressive periodontitis. (22863892)
2012
11
Treatment of generalised aggressive periodontitis: a 4-year follow-up case report. (22866285)
2012
12
A combination of clinical and microbiological management of generalized aggressive periodontitis in primary teeth. A case report. (22066568)
2012
13
Antimicrobial photodynamic therapy in the non-surgical treatment of aggressive periodontitis: microbiological profile. (21399951)
2012
14
Detection of human herpes viruses in patients with chronic and aggressive periodontitis and relationship between viruses and clinical parameters. (22923891)
2012
15
Prevalence of Aggregatibacter actinomycetemcomitans in Sudanese patients with aggressive periodontitis: a case-control study. (21332472)
2011
16
Report of a case of Turner's syndrome with localized aggressive periodontitis. (21976844)
2011
17
Genetic study of families affected with aggressive periodontitis. (21501238)
2011
18
The clinical assessment of aggressive periodontitis patients. (21811690)
2011
19
Local inflammatory markers and systemic endotoxin in aggressive periodontitis. (21730256)
2011
20
Volumetric analysis of intrabony defects in aggressive periodontitis patients following use of a novel composite alloplast: a pilot study. (21519556)
2011
21
Amoxicillin and metronidazole as an adjunctive treatment in generalized aggressive periodontitis at initial therapy or re-treatment: a randomized controlled clinical trial. (21062335)
2011
22
Investigation of the interleukin-1 gene cluster polymorphisms in Jordanian patients with chronic and aggressive periodontitis. (21035110)
2011
23
Response of chronic and aggressive periodontitis to treatment. (20403111)
2010
24
Genetic power of a Brazilian three-generation family with generalized aggressive periodontitis. (20640360)
2010
25
IL-1 gene cluster is not linked to aggressive periodontitis. (20335539)
2010
26
Eosinophilic granuloma or aggressive periodontitis?]. (20074763)
2010
27
Histopathological features of chronic and aggressive periodontitis. (20403104)
2010
28
Immunologic and microbiologic profiles of chronic and aggressive periodontitis subjects. (20450404)
2010
29
Unusual gingival enlargement with aggressive periodontitis: a case report. (20461324)
2010
30
FBAT analysis of polymorphisms of vitamin D receptor (Taq I and Fok I) in aggressive periodontitis families]. (20140038)
2010
31
Aggressive periodontitis and chronic arthritis: blood mononuclear cell gene expression and plasma protein levels of cytokines and cytokine inhibitors. (19186969)
2009
32
Ceruloplasmin induces polymorphonuclear leukocyte priming in localized aggressive periodontitis. (19656030)
2009
33
Relationship of neutrophil phagocytosis and oxidative burst with the subgingival microbiota of generalized aggressive periodontitis. (19239639)
2009
34
Risk of aggressive periodontitis in adolescent carriers of the JP2 clone of Aggregatibacter (Actinobacillus) actinomycetemcomitans in Morocco: a prospective longitudinal cohort study. (18207019)
2008
35
Interleukin-1 and tumor necrosis factor-alpha gene polymorphisms in Turkish patients with localized aggressive periodontitis. (18587204)
2008
36
Association of vitamin D receptor gene polymorphisms in Chinese patients with generalized aggressive periodontitis. (18205735)
2008
37
Platelet-rich plasma in combination with bovine derived xenograft in the treatment of generalized aggressive periodontitis: a case report with re-entry. (17957570)
2007
38
Aggregatibacter actinomycetemcomitans as indicator for aggressive periodontitis by two analysing strategies. (17433043)
2007
39
Timing affects the clinical outcome of adjunctive systemic antibiotic therapy for generalized aggressive periodontitis. (17608574)
2007
40
Demographic, clinical, and microbial aspects of chronic and aggressive periodontitis in Colombia: a multicenter study. (17397309)
2007
41
Incomplete adherence to an adjunctive systemic antibiotic regimen decreases clinical outcomes in generalized aggressive periodontitis patients: a pilot retrospective study. (17711478)
2007
42
Expressions of selected adhesion molecules on peripheral blood leukocytes in patients with aggressive periodontitis. (15995587)
2005
43
Cytokine profile in gingival crevicular fluid of aggressive periodontitis: influence of smoking and stress. (15367195)
2004
44
The -308 polymorphism in the promoter region of the tumor necrosis factor-alpha (TNF-alpha) gene and ex vivo lipopolysaccharide-induced TNF-alpha expression in patients with aggressive periodontitis and/or type 1 diabetes mellitus. (15627647)
2004
45
Aggressive periodontitis of the primary dentition associated with idiopathic immune deficiency: case report and treatment considerations. (15554399)
2004
46
Clinical and radiographic evaluation of Emdogain as a regenerative material in the treatment of interproximal vertical defects in chronic and aggressive periodontitis patients. (15119889)
2004
47
Identification of mRNAs for the various diacylglycerol kinase isoforms in neutrophils from patients with localized aggressive periodontitis. (12941073)
2003
48
Distribution of periodontal pathogens in Korean aggressive periodontitis. (14584866)
2003
49
Lactoferrin iron levels are reduced in saliva of patients with localized aggressive periodontitis. (12083535)
2002
50
Differential gene expression in neutrophils from patients with generalized aggressive periodontitis. (11762875)
2001

Variations for Aggressive Periodontitis

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Expression for genes affiliated with Aggressive Periodontitis

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Expression patterns in normal tissues for genes affiliated with Aggressive Periodontitis

Search GEO for disease gene expression data for Aggressive Periodontitis.

Pathways for genes affiliated with Aggressive Periodontitis

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Compounds for genes affiliated with Aggressive Periodontitis

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Compounds related to Aggressive Periodontitis according to GeneCards/GeneDecks:

(show top 50)    (show all 51)
idCompoundScoreTop Affiliating Genes
1tositumomab50 1111.1FCGR3B, FCGR2A
2ibritumomab50 1111.1FCGR2A, FCGR3B
3alefacept44 1111.1FCGR2A, FCGR3B
4bevacizumab50 1111.1FCGR3B, FCGR2A
5efalizumab44 1111.1FCGR3B, FCGR2A
6cytochalasin b4410.1FPR1, FCGR3B
7daclizumab44 1111.1FCGR2A, FCGR3B
8basiliximab44 1111.1FCGR2A, FCGR3B
9alemtuzumab44 1111.1FCGR3B, FCGR2A
10natalizumab44 1111.1FCGR2A, FCGR3B
11gemtuzumab ozogamicin50 44 1112.1FCGR3B, FCGR2A
12adalimumab44 50 1112.1FCGR3B, FCGR2A
13ciprofloxacin44 50 1112.1IL1A, DEFB1
14abciximab44 1111.0FCGR3B, FCGR2A
15polymyxin b4410.0DEFB1, IL1A
16cetuximab44 50 1112.0FCGR2A, FCGR3B
17etanercept44 50 1112.0FCGR2A, FCGR3B
18pentoxifylline44 1110.9FPR1, IL1A
19leukotriene b444 61 2411.9FCGR3B, IL1A, FPR1
20trastuzumab44 50 1111.9FCGR2A, FCGR3B
21ivig449.9FCGR2A, IL1A
22rantes449.8DEFB1, FPR1, IL1A
23rituximab44 50 1111.7FCGR2A, FCGR3B
24hocl449.7CYBA, MMP8
25phosphoinositide449.7FPR1, FCGR3B, FCGR2A
26fluvastatin44 50 28 1112.6CYBA, IL1A
27mannose449.6FCGR2A, FCAR, FCGR3B
28dbc-amp449.6FPR1, FCGR3B
29tetracycline44 1110.4IL1A, MMP8
30fmlp449.4FCGR2A, FPR1, FCGR3B, IL1A
31n-formylmethionyl-leucylphenylalanine449.4FPR1, IL1A, FCGR3B, CYBA
32cyclosporin a44 28 6111.3MMP8, IL1A, FPR1
33nadph44 2410.3FCGR3B, FPR1, FCGR2A, CYBA
34glutamine449.3FCGR2A, IL1A, CYBA
35genistein44 28 61 2 24 1114.3FPR1, MMP8, FCGR3B, IL1A
36dexamethasone44 50 28 1112.2IL1A, DEFB1, CYBA, FPR1
37pge2449.2FPR1, IL1A, MMP8
38arachidonic acid44 28 24 1112.2FCGR2A, CYBA, FPR1, IL1A
39heparin44 28 24 1112.2IL1A, FCGR2A, FPR1
40histamine44 28 2411.2FCER1A, FPR1, FCGR2A
41retinoic acid44 2410.1MMP8, IL1A, FPR1, DEFB1
42nitric oxide44 24 1110.9FPR1, IL1A, MMP8, CYBA
43oligonucleotide448.9FCGR2A, FPR1, MMP8, CYBA
44tyrosine448.7FPR1, FCAR, FCGR3B, FCGR2A, CYBA
45lipid448.7MMP8, FCGR2A, CYBA, FCGR3B, FPR1
46superoxide44 249.6FCAR, FCGR3B, FPR1, CYBA, MMP8
47oxygen44 249.5MMP8, FCAR, FCGR2A, CYBA, FPR1
48calcium44 50 24 1111.3MMP8, DMP1, FCGR3B, CYBA, FPR1, FCGR2A
49h2o2448.3MMP8, FCGR3B, FCGR2A, CYBA, FPR1, IL1A
50serine448.3MMP8, IL1A, FPR1, FCGR3B, FCGR2A, FCAR

GO Terms for genes affiliated with Aggressive Periodontitis

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Cellular components related to Aggressive Periodontitis according to GeneCards/GeneDecks:

idNameGO IDScoreTop Affiliating Genes
1extracellular regionGO:0055767.9IL1A, MMP8, FCAR, FCGR3B, DMP1, DEFB1

Biological processes related to Aggressive Periodontitis according to GeneCards/GeneDecks:

idNameGO IDScoreTop Affiliating Genes
1immune responseGO:0069558.6IL1A, FCAR, FCGR3B, DEFB1
2innate immune responseGO:0450878.3FCER1A, FCGR2A, CYBA, DEFB1

Molecular functions related to Aggressive Periodontitis according to GeneCards/GeneDecks:

idNameGO IDScoreTop Affiliating Genes
1IgG bindingGO:0198649.7FCGR3B, FCGR2A

Products for genes affiliated with Aggressive Periodontitis

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Sources for Aggressive Periodontitis

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3CDC
13ExPASy
14FMA
22GTR
23HGMD
24HMDB
25ICD10
26ICD10 via Orphanet
27ICD9CM
28IUPHAR
29KEGG
34MeSH
35MESH via Orphanet
36MGI
39NCIt
40NDF-RT
43NINDS
44Novoseek
46OMIM
47OMIM via Orphanet
51PubMed
52QIAGEN
58SNOMED-CT via Orphanet
62UMLS
63UMLS via Orphanet