MCID: AGG001
MIFTS: 55

Aggressive Periodontitis

Categories: Genetic diseases, Oral diseases

Aliases & Classifications for Aggressive Periodontitis

MalaCards integrated aliases for Aggressive Periodontitis:

Name: Aggressive Periodontitis 12 41 14
Periodontitis, Juvenile 69
Juvenile Periodontitis 12

Classifications:



External Ids:

Disease Ontology 12 DOID:1474
ICD10 32 K05.2
MeSH 41 D010520
UMLS 69 C0031106

Summaries for Aggressive Periodontitis

Disease Ontology : 12 A periodontitis that is characterized by rapid attachment loss and bone destruction in the presence of little local factors such as dental plaque and dental calculus resulting in inflammation and a loss of periodontium.

MalaCards based summary : Aggressive Periodontitis, also known as periodontitis, juvenile, is related to periodontitis, aggressive, 1 and gingivitis. An important gene associated with Aggressive Periodontitis is PDON2 (Periodontitis, Localized Aggressive), and among its related pathways/superpathways are Innate Immune System and PEDF Induced Signaling. The drugs Estradiol and Ethinyl Estradiol have been mentioned in the context of this disorder. Affiliated tissues include bone, neutrophil and monocytes, and related phenotypes are hematopoietic system and homeostasis/metabolism

Wikipedia : 72 Aggressive periodontitis describes a type of periodontal disease and includes two of the seven... more...

Related Diseases for Aggressive Periodontitis

Diseases in the Aggressive Periodontitis family:

Periodontitis, Aggressive, 1 Periodontitis, Aggressive, 2

Diseases related to Aggressive Periodontitis via text searches within MalaCards or GeneCards Suite gene sharing:

(show top 50) (show all 317)
# Related Disease Score Top Affiliating Genes
1 periodontitis, aggressive, 1 32.3 CTSC FPR1 IL1A MMP8
2 gingivitis 30.1 CXCL8 IL1A IL1B IL4 IL6 MMP8
3 spondyloarthropathy 1 29.7 IL1RN TNF TNFSF11
4 arthritis 29.0 CXCL8 IL10 IL1A IL1B IL1RN IL6
5 rheumatoid arthritis 28.0 CXCL8 IL10 IL1A IL1B IL1RN IL4
6 periodontitis 27.5 CTSC CXCL8 DEFB1 IL10 IL1A IL1B
7 periodontal disease 27.4 CTSC CXCL8 DEFB1 IL1A IL1B IL1RN
8 susceptibility to localized juvenile periodontitis 12.0
9 punctate inner choroidopathy 10.6 IL10 TNF
10 polyposis, gastric 10.6 IL1B TNF
11 chronic follicular conjunctivitis 10.6 IL1A IL1B
12 systemic onset juvenile idiopathic arthritis 10.6 IL1B TNF
13 scorpion envenomation 10.6 IL6 TNF
14 staphylococcal toxic shock syndrome 10.5 IL1B TNF
15 angioimmunoblastic lymphadenopathy with dysproteinemia 10.5 IL6 TNF
16 microscopic polyangiitis 10.5 IL10 TNF
17 irritant dermatitis 10.5 IL1A IL1B TNF
18 hyperlucent lung 10.5 IL10 IL4
19 multifocal choroiditis 10.5 IL10 TNF
20 critical limb ischemia 10.5 IL6 TNF
21 vulvar vestibulitis syndrome 10.5 IL1B IL1RN TNF
22 cerebral artery occlusion 10.5 IL1B IL1RN TNF
23 meningococcemia 10.5 IL1A IL1B IL1RN
24 laryngitis 10.5 IL1B IL6 TNF
25 acute vascular insufficiency of intestine 10.5 IL1B IL6 TNF
26 poems syndrome 10.5 IL1B IL6 TNF
27 kashin-beck disease 10.5 IL1B TNF
28 multidrug-resistant tuberculosis 10.5 IL10 IL1A TNF
29 burning mouth syndrome 10.5 IL1B IL6 TNF
30 extrapulmonary tuberculosis 10.5 IL10 IL1A IL1B
31 central nervous system vasculitis 10.5 IL1B IL6 TNF
32 eye lymphoma 10.5 IL10 IL6
33 cryopyrin-associated periodic syndrome 10.4 IL1RN IL6
34 endometritis 10.4 IL1B IL6 TNF
35 tropical endomyocardial fibrosis 10.4 IL10 IL4 TNF
36 lacrimal apparatus disease 10.4 IL1B IL6 TNF
37 commensal bacterial infectious disease 10.4 IL1B IL6 TNF
38 listeriosis 10.4 IL10 IL6 TNF
39 radiculopathy 10.4 IL10 IL1A IL6
40 endomyocardial fibrosis 10.4 IL10 IL4 TNF
41 hydrarthrosis 10.4 IL1B IL1RN IL6
42 intermediate uveitis 10.4 IL10 IL6 TNF
43 chikungunya 10.4 IL1B IL6 TNF
44 hemorrhagic fever 10.4 IL10 IL6 TNF
45 hematopoietic stem cell transplantation 10.4 IL10 IL6 TNF
46 intervertebral disc disease 10.4 IL1A IL1B IL6
47 pericarditis 10.4 IL1B IL6 TNF
48 orofacial granulomatosis 10.4 IL10 IL4 TNF
49 plasmodium vivax malaria 10.4 IL10 IL6 TNF
50 haemophilus influenzae 10.4 CXCL8 IL1B TNF

Graphical network of the top 20 diseases related to Aggressive Periodontitis:



Diseases related to Aggressive Periodontitis

Symptoms & Phenotypes for Aggressive Periodontitis

MGI Mouse Phenotypes related to Aggressive Periodontitis:

43
# Description MGI Source Accession Score Top Affiliating Genes
1 hematopoietic system MP:0005397 10.15 IL10 IL1A TLR4 IL1B TNF IL1RN
2 homeostasis/metabolism MP:0005376 10.1 IL6 IL10 MMP8 IL1A TLR4 IL1B
3 immune system MP:0005387 10.07 MMP8 IL1A TLR4 IL1B TNF IL1RN
4 integument MP:0010771 9.85 IL1A TLR4 IL1B TNF IL1RN CTSC
5 neoplasm MP:0002006 9.56 IL10 MMP8 IL1A TLR4 IL1B TNF
6 skeleton MP:0005390 9.28 IL6 IL10 TLR4 IL1B IL1RN FCGR2A

Drugs & Therapeutics for Aggressive Periodontitis

Drugs for Aggressive Periodontitis (from DrugBank, HMDB, Dgidb, PharmGKB, IUPHAR, NovoSeek, BitterDB):

(show top 50) (show all 63)
# Name Status Phase Clinical Trials Cas Number PubChem Id
1
Estradiol Approved, Investigational, Vet_approved Phase 4 50-28-2 5757
2
Ethinyl Estradiol Approved Phase 4 57-63-6 5991
3
Moxifloxacin Approved, Investigational Phase 4 151096-09-2, 354812-41-2 152946
4
Norgestimate Approved, Investigational Phase 4 35189-28-7 6540478
5
Chlorhexidine Approved, Vet_approved Phase 4 55-56-1 2713 9552079
6
Amoxicillin Approved, Vet_approved Phase 4,Phase 2,Phase 3 26787-78-0 33613 2171
7
Metronidazole Approved Phase 4,Phase 2,Phase 3 443-48-1 4173
8 Anti-Bacterial Agents Phase 4,Phase 2,Phase 3
9 Anti-Infective Agents Phase 4,Phase 2,Phase 3
10 Contraceptive Agents Phase 4
11 Contraceptives, Oral Phase 4
12 Contraceptives, Oral, Combined Phase 4
13 Estradiol 17 beta-cypionate Phase 4
14 Estradiol 3-benzoate Phase 4
15 Estradiol valerate Phase 4 979-32-8
16 Fluoroquinolones Phase 4
17 Norgestimate, ethinyl estradiol drug combination Phase 4
18 Nucleic Acid Synthesis Inhibitors Phase 4
19 Polyestradiol phosphate Phase 4
20 Topoisomerase Inhibitors Phase 4
21 Chlorhexidine gluconate Phase 4
22 Antibiotics, Antitubercular Phase 4,Phase 2,Phase 3
23 Antiparasitic Agents Phase 4,Phase 2,Phase 3
24 Antiprotozoal Agents Phase 4,Phase 2,Phase 3
25 Anesthetics Phase 4
26 Anesthetics, Local Phase 4
27
Clarithromycin Approved Phase 2, Phase 3 81103-11-9 84029
28
Aspirin Approved, Vet_approved Phase 2, Phase 3 50-78-2 2244
29 Cytochrome P-450 CYP3A Inhibitors Phase 2, Phase 3
30 Cytochrome P-450 Enzyme Inhibitors Phase 2, Phase 3
31 Analgesics Phase 2, Phase 3
32 Analgesics, Non-Narcotic Phase 2, Phase 3
33 Anti-Inflammatory Agents Phase 2, Phase 3
34 Anti-Inflammatory Agents, Non-Steroidal Phase 2, Phase 3
35 Antipyretics Phase 2, Phase 3
36 Antirheumatic Agents Phase 2, Phase 3
37 Cyclooxygenase Inhibitors Phase 2, Phase 3
38 Fibrinolytic Agents Phase 2, Phase 3
39 Peripheral Nervous System Agents Phase 2, Phase 3
40 Platelet Aggregation Inhibitors Phase 2, Phase 3
41 Omega 3 Fatty Acid Nutraceutical Phase 2, Phase 3
42
Nitric Oxide Approved 10102-43-9 145068
43
Ergocalciferol Approved, Nutraceutical 50-14-6 5280793
44
Vitamin D Approved, Nutraceutical, Vet_approved 1406-16-2
45 Bone Density Conservation Agents
46 Dihydroxycholecalciferols
47 Ergocalciferols
48 Micronutrients
49 Trace Elements
50 Vitamins

Interventional clinical trials:

(show all 39)

# Name Status NCT ID Phase Drugs
1 Adjunctive Systemic Administration of Moxifloxacin in the Treatment of Aggressive Periodontitis Completed NCT02125812 Phase 4
2 Evaluation of Efficacy of Full-mouth Disinfection in Generalized Aggressive Periodontitis Patients Completed NCT02466646 Phase 4 Klorhex® Gel, rinse and sprey
3 Treatment of Aggressive Periodontitis With Repeated Adjunctive Antimicrobial Photodynamic Therapy Completed NCT02049008 Phase 4
4 Host Modulatory Effects of β-glucan on Localized Aggressive Periodontitis Completed NCT02402296 Phase 4 β-1,3/1,6-D-glucan
5 Alternative Antibiotic Regime in the Treatment of GAgP Completed NCT02223702 Phase 4 Amoxicillin;Metronidazole;Moxifloxacin
6 Efficacy of Three Antibiotic Protocols for Aggressive Periodontitis Treatment Recruiting NCT02839421 Phase 4 Scaling and Root Planing combined with moxifloxacin
7 Enamel Matrix Proteins in the Treatment of Intrabony Defects in Patients With Aggressive and Chronic Periodontitis Recruiting NCT03025204 Phase 4
8 Two Different Antibiotic Agents to Treat Generalized Aggressive Periodontitis Completed NCT02969928 Phase 2, Phase 3 Clarithromycin;Amoxicillin;Metronidazole
9 Periodontal Debridement Associated With Systemic Antibiotics and Single/Repeated PDT to Treat Aggressive Periodontitis Completed NCT03132714 Phase 2, Phase 3 Amoxicillin 500mg;Metronidazole 400mg;Clarithromycin 500mg
10 Omega-3 Plus Low-dose Aspirin Daily Supplementation in Non-surgical Therapy to Treat Aggressive Periodontitis Recruiting NCT03093246 Phase 2, Phase 3 Aspirin
11 Omega-3 Fatty Acids Plus Low-dose Aspirin Daily Supplementation in Surgical Therapy to Treat Aggressive Periodontitis Recruiting NCT03093207 Phase 2, Phase 3 Aspirin
12 The Affect of Orthodontic Treatment on the Periodontal Status of Patients With Aggressive Periodontitis Unknown status NCT01510808
13 Polymorphonuclear Cells' Sensitivity to Aggregatibacter Actinomycetemcomitans Bacteria in Patients With Aggressive Periodontitis Unknown status NCT02010307
14 Chronic Presence of Epstein Barr Virus in Epithelial Cells From Gingiva is Associated With Periodontitis Unknown status NCT01246596
15 Gene Expression Profiles in Generalized Aggressive Periodontitis: A Gene Network-based Microarray Analysis Completed NCT02327533 Early Phase 1
16 Immunolocalization of 1,25,Dihydroxyvitamin D3 in Aggressive Periodontitis Patients Completed NCT02282800
17 Effects Of Adjunctive Photodynamic Therapy To Non-Surgical Periodontal Treatment In Patients With Generalized Aggressive Periodontitis Completed NCT03412331
18 Gingival Crevicular Fluid Levels Of Monocyte Chemoattractant Protein-1 Completed NCT02927704
19 Frequency Of MCP-1 And CCR2 Gene Polymorphisms And Its Effect On Gene Expression In Patients With AgP Completed NCT02817568
20 Effects of Er,Cr:YSGG, Diode Lasers on GCF Cytokines Levels Completed NCT03034824
21 Clarithromycin as Adjuvant to Periodontal Debridement Completed NCT02829983 Clarithromycin;Placebo
22 Smoking Influence on Apoptosis in Periodontitis Completed NCT02111005
23 Nonsurgical Periodontal Treatment Associated or Not With Systemic Antibiotics and Photodynamic Therapy Completed NCT03142776 systemic clarithromycin
24 Estimation of Pentrexin-3 Levels in GCF and Saliva of Patients With Periodontal Disease Completed NCT03128502
25 Effect of Surgical Therapy on RANKL/OPG (Osteoprotegerin) System Completed NCT02190773
26 Nitro-oxidative Stress in Periodontitis Completed NCT02127203
27 The Importance of Periostin in Periodontal Health and Disease Completed NCT01180920
28 Gingival Bleeding and Von Willebrand Disease Typ 2 and 3 Completed NCT03078595
29 Perforated Collagen Membrane With Nanohydroxyapatite for Intrabony Defects Completed NCT03399279
30 Immediate Implant Placement in Aggressive Periodontitis Recruiting NCT03218228
31 Subgingival Microbiome Following Mechanical Treatment and it's Effect on Peri-implant Sub-mucosa in Aggressive Periodontitis Patients Recruiting NCT03090282
32 Mechanisms and Treatment Response of Aggressive Periodontitis in Children Recruiting NCT01330719
33 EMD for Treatment of Proximal Class-II Furcation Involvements Recruiting NCT03320135
34 B Cell Functions in Periodontitis Recruiting NCT02833285
35 Interaction Between Immune Cells and Bacteria Associated With Periodontitis Recruiting NCT03225950
36 Comparison Between Surgical Access and Repeated Applications of APDT Active, not recruiting NCT03140059
37 Long-term Results After Systematic Periodontal Therapy Enrolling by invitation NCT03048045
38 Clinical and Radiographic Evaluation of Guided Tissue Regeneration With Radiation-sterilized Allogenic Bone Grafts or Xenogenic Grafts for the Treatment of Intrabony Defects in Aggressive Periodontitis Not yet recruiting NCT03340012
39 Analysis of Osteoimmune Interactions Linking Inflammation and Bone Destruction in Aggressive Periodontitis Terminated NCT01993368

Search NIH Clinical Center for Aggressive Periodontitis

Cochrane evidence based reviews: aggressive periodontitis

Genetic Tests for Aggressive Periodontitis

Anatomical Context for Aggressive Periodontitis

MalaCards organs/tissues related to Aggressive Periodontitis:

38
Bone, Neutrophil, Monocytes, B Cells, Whole Blood, Colon, T Cells

Publications for Aggressive Periodontitis

Articles related to Aggressive Periodontitis:

(show top 50) (show all 592)
# Title Authors Year
1
Definition of aggressive periodontitis in periodontal research. A systematic review. ( 29226356 )
2018
2
Diagnosis of aggressive periodontitis: A dilemma? ( 29363676 )
2018
3
CCR5I932 (rs333) polymorphism is associated with decreased risk of chronic and aggressive periodontitis: A case-control analysis based in disease resistance and susceptibility phenotypes. ( 28969941 )
2018
4
Impact of aggressive periodontitis and chronic periodontitis on oral health-related quality of life. ( 29451591 )
2018
5
Localised aggressive periodontitis in a 3-year-old-boy. ( 29332208 )
2018
6
Treatment of intrabony defects with modified perforated membranes in aggressive periodontitis: a 12-month randomized controlled trial. ( 29411112 )
2018
7
Comprehensive rehabilitation using dental implants in generalized aggressive periodontitis. ( 29398863 )
2017
8
Adjunctive Effect of Autologous Platelet-Rich Fibrin in the Treatment of Intrabony Defects in Localized Aggressive Periodontitis Patients: A Randomized Controlled Split-Mouth Clinical Trial. ( 29023611 )
2017
9
Long-term treatment costs for aggressive periodontitis in a German population. ( 28905412 )
2017
10
Clarithromycin as an Adjunct to One-Stage Full Mouth Ultrasonic Periodontal Debridement in Generalized Aggressive Periodontitis: a Randomized Controlled Clinical Trial. ( 28671507 )
2017
11
Dental anxiety and oral health-related quality of life in aggressive periodontitis patients. ( 29022175 )
2017
12
The Effects of Diode Laser Therapy as an Adjunct to Scaling and Root Planing in the Treatment of Aggressive Periodontitis: A 1-Year Randomized Controlled Clinical Trial. ( 28945145 )
2017
13
Moderate- to long-term therapeutic outcomes of treated aggressive periodontitis patients without regular supportive care. ( 29105779 )
2017
14
Salivary and Serum Markers Related to Innate Immunity in Generalized Aggressive Periodontitis. ( 28753101 )
2017
15
Aggregatibacter actinomycetemcomitans in African Americans with Localized Aggressive Periodontitis. ( 28879247 )
2017
16
The Effect of Nonsurgical Periodontal Therapy on the Level of Human Neutrophil Peptides 1-3 in Patients with Aggressive Periodontitis. ( 28944351 )
2017
17
Transcriptome of Healthy Gingival Tissue from Edentulous Sites in Patients with a History of Aggressive Periodontitis. ( 28844188 )
2017
18
Association of NOD2 Mutations with Aggressive Periodontitis. ( 28682159 )
2017
19
Shift in the Subgingival Microbiome following Scaling and Root Planing in Generalized Aggressive Periodontitis. ( 29266363 )
2017
20
More than two-thirds of patients with localized aggressive periodontitis gained more than 2 millimeters of clinical attachment level after 4 years of maintenance treatment. ( 28666521 )
2017
21
Differential Diagnosis between Chronic versus Aggressive Periodontitis and Staging of Aggressive Periodontitis: A Cross-sectional Study. ( 29326511 )
2017
22
Aggressive periodontitis associated with Kindler syndrome in a large Kindler syndrome pedigree. ( 29168364 )
2017
23
Effect of scaling & root planing on the activity of ALP in GCF & serum of patients with gingivitis, chronic and aggressive periodontitis: A comparative study. ( 28706787 )
2017
24
Evaluation of microbiota associated with Herpesviruses in active sites of generalized aggressive periodontitis. ( 29299190 )
2017
25
Cytokine profile in gingival crevicular fluid and plasma of patients with aggressive periodontitis. ( 28868949 )
2017
26
Immature, but Not Mature, Dendritic Cells Are More Often Present in Aggressive Periodontitis Than Chronic Periodontitis: An Immunohistochemical Study. ( 28841097 )
2017
27
Disease Staging Index for Aggressive Periodontitis. ( 28831460 )
2017
28
Non-Surgical Therapy Reduces Presence of JP2 Clone in Localized Aggressive Periodontitis. ( 28820321 )
2017
29
Epigenetic regulation of inflammation in localized aggressive periodontitis. ( 28883894 )
2017
30
Potential Risk for Localized Aggressive Periodontitis in African American Preadolescent Children. ( 29122069 )
2017
31
Diagnosis and Management of Chronic and Aggressive Periodontitis Part 2: Periodontal Management. ( 29188693 )
2017
32
Local and Plasma Biomarker Profiles in Localized Aggressive Periodontitis. ( 28879248 )
2017
33
Diagnosis and Management of Chronic and Aggressive Periodontitis Part 1: Periodontal Assessment and Diagnosis. ( 29172354 )
2017
34
Towards the targeted management of aggressive periodontitis. ( 28571797 )
2017
35
Autologous Platelet Rich Fibrin in the Treatment of 3-Wall Intrabony Defects in Aggressive Periodontitis - A Randomized Controlled Clinical Trial. ( 28820320 )
2017
36
IL-6 and IL-10 gene polymorphisms in patients with aggressive periodontitis: effects on GCF, serum and clinic parameters. ( 28099578 )
2017
37
Herpesviruses in etiopathogenesis of aggressive periodontitis: A meta-analysis based on case-control studies. ( 29036216 )
2017
38
Clinical Characteristics of Localized Aggressive Periodontitis in Primary Dentition. ( 29087795 )
2017
39
Comparing the efficiency of Er,Cr:YSGG laser and diode laser on human I^-defensin-1 and IL-1I^ levels during the treatment of generalized aggressive periodontitis and chronic periodontitis. ( 28557642 )
2017
40
Treatment compliance in patients with aggressive periodontitis - a retrospective case-control study. ( 27899029 )
2017
41
Biomarker levels in gingival crevicular fluid of generalized aggressive periodontitis patients after non-surgical periodontal treatment. ( 28918557 )
2017
42
Radiographic Description of the Distribution of Aggressive Periodontitis in Primary Teeth. ( 29087797 )
2017
43
Inflammatory Response Influences Treatment of Localized Aggressive Periodontitis. ( 26917438 )
2016
44
Predictors of clinical outcomes after periodontal treatment of aggressive periodontitis: 12-month randomized trial. ( 27223128 )
2016
45
Tooth loss and alveolar bone crest loss during supportive periodontal therapy in patients with generalized aggressive periodontitis: retrospective study with follow-up of 8 to 15 years. ( 27396322 )
2016
46
Association of Interleukin-17 polymorphism (-197G/A) in chronic and localized aggressive periodontitis. ( 26910014 )
2016
47
The microbial community shifts of subgingival plaque in patients with generalized aggressive periodontitis following non-surgical periodontal therapy: a pilot study. ( 27732961 )
2016
48
Analysis of polymorphisms in Interleukin 10, NOS2A, and ESR2 genes in chronic and aggressive periodontitis. ( 27737359 )
2016
49
Effect of patient age awareness on diagnostic agreement of chronic or aggressive periodontitis between clinicians; a pilot study. ( 27456238 )
2016
50
Long-term clinical response to treatment and maintenance of localized aggressive periodontitis: a cohort study. ( 27767222 )
2016

Variations for Aggressive Periodontitis

Expression for Aggressive Periodontitis

Search GEO for disease gene expression data for Aggressive Periodontitis.

Pathways for Aggressive Periodontitis

Pathways related to Aggressive Periodontitis according to GeneCards Suite gene sharing:

(show top 50) (show all 65)
# Super pathways Score Top Affiliating Genes
1
Show member pathways
14.04 CTSC CXCL8 DEFB1 FCGR2A FPR1 IL10
2
Show member pathways
13.7 CXCL8 IL10 IL1A IL1B IL4 IL6
3
Show member pathways
13.48 CXCL8 IL10 IL1A IL1B IL4 IL6
4
Show member pathways
13.43 CXCL8 FPR1 IL10 IL1A IL1B IL1RN
5
Show member pathways
13.37 CXCL8 IL10 IL1A IL1B IL4 IL6
6
Show member pathways
13.06 CXCL8 IL1A IL1B IL1RN IL6 TLR4
7
Show member pathways
12.96 CXCL8 IL10 IL1A IL1B IL4 IL6
8
Show member pathways
12.9 CXCL8 IL1A IL1B IL4 IL6 TLR4
9
Show member pathways
12.74 IL1A IL1B IL6 TLR4 TNF
10
Show member pathways
12.7 IL10 IL1A IL1B IL4 IL6 TLR4
11 12.67 IL10 IL1B IL1RN IL4 TNF TNFSF11
12
Show member pathways
12.66 IL1A IL1B TLR4 TNF TNFSF11
13
Show member pathways
12.64 CXCL8 IL10 IL1B IL6 TLR4 TNF
14
Show member pathways
12.55 IL10 IL1A IL1B IL4 IL6 TNF
15
Show member pathways
12.43 CXCL8 IL1B IL4 IL6 TNF
16
Show member pathways
12.38 CXCL8 IL1A IL1B IL6 TLR4 TNF
17
Show member pathways
12.37 IL1B IL4 IL6 TNF
18
Show member pathways
12.36 CXCL8 IL1A IL6 TLR4 TNF
19
Show member pathways
12.35 FCGR2A IL10 IL1A IL1B IL4 TLR4
20 12.32 FCGR2A IL10 IL1A IL1B IL6 TLR4
21
Show member pathways
12.29 CXCL8 IL1B IL4 IL6 TLR4 TNF
22 12.27 CXCL8 IL10 IL1A IL1B IL1RN IL6
23
Show member pathways
12.26 IL1A IL1B TLR4 TNF
24
Show member pathways
12.23 CXCL8 IL10 IL1A IL1B IL4 IL6
25 12.17 FCGR2A IL1A IL1B TNF TNFSF11
26 12.12 FCGR2A IL10 IL4 IL6 TNF
27
Show member pathways
12.07 IL10 IL1B IL6 TLR4 TNF
28 12.06 CXCL8 IL10 IL1A IL1B IL4 IL6
29 12.04 CXCL8 IL1A IL1B IL6 TNF
30 12.03 CXCL8 IL1A IL1B IL6
31 12.02 IL1A IL1B IL4 IL6 TNF
32 12.01 CXCL8 IL1B TLR4 TNF TNFSF11
33 12.01 CXCL8 IL10 IL1B IL6 TLR4 TNF
34
Show member pathways
11.96 IL1B IL4 IL6 TLR4
35 11.96 CXCL8 IL1A IL1B IL6 TLR4
36 11.9 IL10 IL1B IL4 TNF
37
Show member pathways
11.88 CXCL8 IL6 TLR4
38 11.87 CXCL8 IL1A IL1B IL6 TLR4 TNF
39 11.86 IL10 IL1B IL6 TNF
40 11.82 CXCL8 IL4 IL6
41
Show member pathways
11.79 CXCL8 IL4 TNF
42 11.79 CXCL8 IL1B IL4 IL6 TNF
43 11.79 FCGR2A IL10 IL4 IL6 TLR4 TNF
44
Show member pathways
11.78 CXCL8 IL1A IL1B IL6 TNF
45 11.71 CXCL8 IL1B IL6 TLR4 TNF
46 11.68 CXCL8 IL10 IL1A IL1B IL6 TLR4
47 11.65 FCGR2A FPR1 IL10
48 11.64 CXCL8 FCGR2A IL1A IL1B IL4 IL6
49 11.63 IL1A TLR4 TNF
50 11.61 IL1A IL1B IL6 TNF TNFSF11

GO Terms for Aggressive Periodontitis

Cellular components related to Aggressive Periodontitis according to GeneCards Suite gene sharing:

# Name GO ID Score Top Affiliating Genes
1 extracellular region GO:0005576 9.73 CTSC CXCL8 DEFB1 IL10 IL1A IL1B
2 extracellular space GO:0005615 9.4 CTSC CXCL8 DEFB1 IL10 IL1A IL1B

Biological processes related to Aggressive Periodontitis according to GeneCards Suite gene sharing:

(show top 50) (show all 54)
# Name GO ID Score Top Affiliating Genes
1 defense response to bacterium GO:0042742 9.98 DEFB1 IL10 TLR4 TNF
2 positive regulation of I-kappaB kinase/NF-kappaB signaling GO:0043123 9.95 IL1B TLR4 TNF TNFSF11
3 chemotaxis GO:0006935 9.95 CXCL8 DEFB1 FPR1 IL4
4 cytokine-mediated signaling pathway GO:0019221 9.92 IL1A IL1B IL6 TNFSF11
5 defense response to Gram-positive bacterium GO:0050830 9.89 DEFB1 IL6 TNF
6 response to organic substance GO:0010033 9.88 CTSC IL10 TNF
7 activation of MAPK activity GO:0000187 9.88 FPR1 IL1B TLR4 TNF
8 defense response to Gram-negative bacterium GO:0050829 9.87 DEFB1 IL6 TLR4
9 positive regulation of T cell proliferation GO:0042102 9.85 IL1B IL4 IL6
10 positive regulation of NF-kappaB transcription factor activity GO:0051092 9.85 IL1B IL6 TLR4 TNF TNFSF11
11 cellular response to lipopolysaccharide GO:0071222 9.83 CXCL8 IL10 IL6 TLR4 TNF
12 positive regulation of interferon-gamma production GO:0032729 9.82 IL1B TLR4 TNF
13 positive regulation of nitric oxide biosynthetic process GO:0045429 9.81 IL1B TLR4 TNF
14 positive regulation of JNK cascade GO:0046330 9.81 IL1B TLR4 TNF TNFSF11
15 regulation of receptor activity GO:0010469 9.81 CXCL8 IL10 IL1A IL1B IL1RN IL4
16 response to glucocorticoid GO:0051384 9.8 IL10 IL1RN IL6 TNF
17 negative regulation of extrinsic apoptotic signaling pathway in absence of ligand GO:2001240 9.77 IL1A IL1B TNF
18 lipopolysaccharide-mediated signaling pathway GO:0031663 9.77 IL1B TLR4 TNF
19 positive regulation of DNA binding transcription factor activity GO:0051091 9.77 IL10 IL1B IL6 TNF TNFSF11
20 positive regulation of cytokine secretion GO:0050715 9.76 IL10 IL1A TNF
21 positive regulation of interleukin-8 production GO:0032757 9.74 IL1B TLR4 TNF
22 negative regulation of interleukin-6 production GO:0032715 9.73 IL10 TLR4 TNF
23 negative regulation of growth of symbiont in host GO:0044130 9.72 IL10 TNF
24 positive regulation of NF-kappaB import into nucleus GO:0042346 9.72 IL1B TLR4 TNF
25 regulation of I-kappaB kinase/NF-kappaB signaling GO:0043122 9.71 IL1B TNF
26 response to molecule of bacterial origin GO:0002237 9.71 CXCL8 IL10
27 positive regulation of chemokine production GO:0032722 9.71 IL6 TLR4 TNF
28 positive regulation of interleukin-2 biosynthetic process GO:0045086 9.7 IL1A IL1B
29 positive regulation of monocyte chemotactic protein-1 production GO:0071639 9.7 IL1A IL1B
30 negative regulation of heterotypic cell-cell adhesion GO:0034115 9.7 IL10 IL1RN
31 negative regulation of lipid storage GO:0010888 9.69 IL6 TNF
32 positive regulation of chemokine biosynthetic process GO:0045080 9.69 IL1B TNF
33 positive regulation of interleukin-8 biosynthetic process GO:0045416 9.69 TLR4 TNF
34 endothelial cell apoptotic process GO:0072577 9.68 IL10 TNF
35 regulation of establishment of endothelial barrier GO:1903140 9.68 IL1B TNF
36 ectopic germ cell programmed cell death GO:0035234 9.68 IL1A IL1B
37 negative regulation of cytokine secretion involved in immune response GO:0002740 9.67 IL10 TNF
38 type 2 immune response GO:0042092 9.66 IL10 IL4
39 positive regulation of fever generation GO:0031622 9.65 IL1B TNF
40 positive regulation of heterotypic cell-cell adhesion GO:0034116 9.65 IL10 IL1B TNF
41 positive regulation of interleukin-6 production GO:0032755 9.65 IL1A IL1B IL6 TLR4 TNF
42 sequestering of triglyceride GO:0030730 9.63 IL1B TNF
43 regulation of isotype switching GO:0045191 9.63 IL10 IL4
44 negative regulation of interleukin-1-mediated signaling pathway GO:2000660 9.62 IL1RN IL6
45 receptor biosynthetic process GO:0032800 9.61 IL10 TNF
46 positive regulation of calcidiol 1-monooxygenase activity GO:0060559 9.61 IL1B TNF
47 inflammatory response GO:0006954 9.61 CXCL8 FPR1 IL10 IL1A IL1B IL1RN
48 positive regulation of MHC class II biosynthetic process GO:0045348 9.58 IL10 IL4 TLR4
49 fever generation GO:0001660 9.5 IL1A IL1B IL1RN
50 immune response GO:0006955 9.4 CTSC CXCL8 DEFB1 IL10 IL1A IL1B

Molecular functions related to Aggressive Periodontitis according to GeneCards Suite gene sharing:

# Name GO ID Score Top Affiliating Genes
1 cytokine activity GO:0005125 9.28 CXCL8 IL10 IL1A IL1B IL1RN IL4
2 interleukin-1 receptor binding GO:0005149 9.13 IL1A IL1B IL1RN

Sources for Aggressive Periodontitis

3 CDC
7 CNVD
9 Cosmic
10 dbSNP
11 DGIdb
16 ExPASy
18 FMA
27 GO
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29 HGMD
30 HMDB
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65 SNOMED-CT via HPO
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67 TGDB
68 Tocris
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