MCID: AGG001
MIFTS: 48

Aggressive Periodontitis malady

Summaries for Aggressive Periodontitis

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8Disease Ontology, 63Wikipedia, 46OMIM, 32MalaCards
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Disease Ontology:8 A periodontitis that is characterized by rapid attachment loss and bone destruction in the presence of little local factors such as dental plaque and dental calculus resulting in inflammation and a loss of periodontium.

MalaCards: Aggressive Periodontitis, also known as periodontitis, juvenile, is related to periodontitis and gingivitis. An important gene associated with Aggressive Periodontitis is FPR1 (formyl peptide receptor 1), and among its related pathways are Staphylococcus aureus infection and Osteoclast differentiation. The compounds etanercept and adalimumab have been mentioned in the context of this disorder. Affiliated tissues include bone, monocytes and whole blood, and related mouse phenotype immune system.

Wikipedia:63 Aggressive periodontitis describes a type of periodontal disease and includes two of the seven... more...

Description from OMIM:46 608526,170650

Aliases & Classifications for Aggressive Periodontitis

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8Disease Ontology, 10DISEASES, 60UMLS, 44Novoseek, 46OMIM, 56SNOMED-CT, 34MeSH
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Aliases & Descriptions:

aggressive periodontitis 8 10 60
periodontitis, juvenile 60
periodontitis juvenile 44
juvenile periodontitis 8


External Ids:

Disease Ontology8 DOID:1474
SNOMED-CT56 49965002, 2624008
MeSH34 D010520

Related Diseases for Aggressive Periodontitis

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17GeneCards, 18GeneDecks
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Diseases in the Aggressive Periodontitis family:

Periodontitis, Aggressive, 2

Diseases related to Aggressive Periodontitis via text searches within MalaCards or GeneCards/GeneDecks gene sharing:

(show all 49)
idRelated DiseaseScoreTop Affiliating Genes
1periodontitis32.0DEFB1, IL1A, IL1RN
2gingivitis31.2IL1A
3periodontal disease30.7IL1A, IL1RN, DEFB1, CTSC
4arthritis30.5IL1A, FCGR3B, IL1RN, MMP12, FCGR2A
5sarcoidosis30.0IL1RN, IL1A, HLA-S, DEFB1
6periodontosis10.6
7juvenile rheumatoid arthritis10.3
8type 1 diabetes mellitus10.3
9diabetes mellitus10.3
10rheumatoid arthritis10.3
11leukocyte disease10.2
12periodontitis 1, juvenile10.2
13cutaneous lupus erythematosus10.0
14fanconi's anemia10.0
15amelogenesis imperfecta10.0
16rickets10.0
17dental caries10.0
18gingival disease10.0
19intellectual disability10.0
20lupus erythematosus10.0
21tooth disease10.0
22tooth agenesis10.0
23dentinogenesis imperfecta10.0
24pustulosis palmaris et plantaris10.0
25tuberculosis10.0FPR1, CD1A
26celiac disease10.0MMP12
27skin disease10.0IL1A
28sepsis10.0IL1A, DEFB1, FCGR2A, IL1RN, FPR1, FCGR3B
29neutropenia10.0FCGR3B, IL1RN, FPR1
30leukemia10.0CD1A, IL1A, FPR1, FCGR3B, DGKQ
31otitis media10.0DEFB1
32psoriasis10.0HLA-S, IL1A
33hypersensitivity reaction type ii disease10.0IL1A, IL1RN, CD1A, HLA-S, FCGR3B, FCGR2A
34asthma10.0DEFB1, FCER1A, CD1A, MMP12, FCGR3B
35vasculitis10.0FCGR3B
36multiple sclerosis10.0MMP12, IL1RN
37schnitzler syndrome10.0IL1RN
38dermatitis10.0IL1A
39ipex syndrome10.0HLA-S, FPR1, FCGR3B, CTSC, FCGR2A
40colon cancer10.0CTSC, DMP1
41allergic rhinitis10.0FCER1A
42neisseria meningitidis infection10.0FCGR2A, IL1RN
43graves' disease10.0IL1RN, IL1A
44histiocytosis10.0CD1A
45nephritis10.0FCGR2A, FCGR3B, IL1RN
46adenocarcinoma10.0MMP26, MMP12, CTSC
47melanoma10.0MMP26, CD1A, IL1A, MMP12, FCGR2A
48cystic fibrosis10.0DEFB1
49systemic scleroderma10.0IL1A, MMP12, FCGR3B

Graphical network of the top 20 diseases related to Aggressive Periodontitis:



Diseases related to aggressive periodontitis

Clinical Features for Aggressive Periodontitis

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46OMIM
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Clinical features from OMIM:

608526,170650

Drugs & Therapeutics for Aggressive Periodontitis

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Sources:
5CenterWatch, 41NIH Clinical Center, 6ClinicalTrials, 60UMLS, 40NDF-RT
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Approved drugs:

Search CenterWatch for Aggressive Periodontitis

Drug clinical trials:

Search ClinicalTrials for Aggressive Periodontitis

Search NIH Clinical Center for Aggressive Periodontitis

Search CenterWatch for Aggressive Periodontitis

Genetic Tests for Aggressive Periodontitis

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Anatomical Context for Aggressive Periodontitis

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32MalaCards
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MalaCards organs/tissues related to Aggressive Periodontitis:

32
Bone, Monocytes, Whole blood, Colon, T cells

Animal Models for Aggressive Periodontitis or affiliated genes

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36MGI
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MGI Mouse Phenotypes related to Aggressive Periodontitis:

36
idDescriptionMGI Source AccessionScoreTop Affiliating Genes
1MP:000538710.4FCER1A, FCGR2A, MMP12, FPR1, IL1A, IL1RN

Publications for Aggressive Periodontitis

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50PubMed
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Articles related to Aggressive Periodontitis:

(show top 50)    (show all 465)
idTitleAuthorsYear
1
Alternative Splicing Generates a Diacylglycerol Kinase I+ (DGKI+) Transcript That Acts as a Dominant Negative Modulator of Superoxide Production in Localized Aggressive Periodontitis. (24171497)
2013
2
mRNA expression of MMP-28 (Epilysin) in gingival tissues of chronic and aggressive periodontitis patients: a reverse transcriptase PCR study. (24167355)
2013
3
Nonsurgical treatment of aggressive periodontitis with photodynamic therapy or systemic antibiotics. Three-month results of a randomized, prospective, controlled clinical study. (23836044)
2013
4
Antimicrobial photodynamic therapy in the non-surgical treatment of aggressive periodontitis: microbiological profile. (21399951)
2012
5
Detection of human herpes viruses in patients with chronic and aggressive periodontitis and relationship between viruses and clinical parameters. (22923891)
2012
6
Clinical evaluation of intrabony defects in localized aggressive periodontitis patients with and without bioglass- an in-vivo study. (22971854)
2012
7
Association of interleukin-10 gene promoter polymorphisms with chronic and aggressive periodontitis. (22077544)
2012
8
Quantitative discrimination of Aggregatibacter actinomycetemcomitans highly leukotoxic JP2 clone from non-JP2 clones in diagnosis of aggressive periodontitis. (23050598)
2012
9
Role of antibiotics in generalized aggressive periodontitis: A review of clinical trials in humans. (23162322)
2012
10
Periodontal and space maintenance considerations for primary teeth presenting with aggressive periodontitis: a case report. (22795162)
2012
11
Prevalence of Aggregatibacter actinomycetemcomitans in Sudanese patients with aggressive periodontitis: a case-control study. (21332472)
2011
12
Genetic study of families affected with aggressive periodontitis. (21501238)
2011
13
Genetic polymorphism of MUC7 in individuals with aggressive or chronic periodontitis. (22167029)
2011
14
Dynamic therapeutic approach for individuals affected with aggressive periodontitis. (21823498)
2011
15
Calprotectin levels in gingival crevicular fluid predict disease activity in patients treated for generalized aggressive periodontitis. (21488873)
2011
16
Aggressive periodontitis: the silent tooth killer. (22686102)
2011
17
Microbiological and immunological characteristics of young Moroccan patients with aggressive periodontitis with and without detectable Aggregatibacter actinomycetemcomitans JP2 infection. (21214871)
2011
18
Generalized aggressive periodontitis. (21534357)
2011
19
Production of interleukin-13 is influenced by the interleukin-4 -34TT and -590TT genotype in patients with aggressive periodontitis. (21198753)
2011
20
Unusual gingival enlargement with aggressive periodontitis: a case report. (20461324)
2010
21
FBAT analysis of polymorphisms of vitamin D receptor (Taq I and Fok I) in aggressive periodontitis families]. (20140038)
2010
22
Serum levels of cytokines in subjects with generalized chronic and aggressive periodontitis before and after non-surgical periodontal therapy: a pilot study. (20192617)
2010
23
Initial periodontal therapy reduced systemic and local 25-hydroxy vitamin D(3) and interleukin-1beta in patients with aggressive periodontitis. (20151805)
2010
24
Clinical and microbiological effects of mechanical instrumentation and local antimicrobials during periodontal supportive therapy in aggressive periodontitis patients: smoker versus non-smoker patients. (20849433)
2010
25
Genetic variants associated with neutrophil function in aggressive periodontitis and healthy controls. (20367096)
2010
26
Elevated plasma calcifediol is associated with aggressive periodontitis. (19563291)
2009
27
Risk indicators for aggressive periodontitis in an untreated isolated young population from Brazil. (19684958)
2009
28
Neutrophils in chronic and aggressive periodontitis in interaction with Porphyromonas gingivalis and Aggregatibacter actinomycetemcomitans. (19210340)
2009
29
The interleukin-10 promoter haplotype ATA is a putative risk factor for aggressive periodontitis. (18230105)
2008
30
Comments on: M. Zigmond et al. (2006) The outcome of a preventive dental care programme on the prevalence of localized aggressive periodontitis in Down's syndrome (DS) individuals (Journal of Intellectual Disability Research, 50(7), pp. 492-500). (18173577)
2008
31
Blood cell gene expression profiling in subjects with aggressive periodontitis and chronic arthritis. (18315430)
2008
32
The use of 2 antibiotic regimens in aggressive periodontitis: comparison of changes in clinical parameters and gingival crevicular fluid biomarkers. (19093057)
2008
33
Aggressive periodontitis: a case report. (19263735)
2008
34
Polymorphisms within the IL-1 gene cluster: effects on cytokine profiles in peripheral blood and whole blood cell cultures of patients with aggressive periodontitis, juvenile idiopathic arthritis, and rheumatoid arthritis. (17335371)
2007
35
Aggressive periodontitis with streptococcal gingivitis: a case report. (19212476)
2007
36
Atherogenic lipoprotein parameters in patients with aggressive periodontitis. (17956461)
2007
37
Aggressive periodontitis in a patient with chronic cutaneous lupus erythematosus: a case report. (16683689)
2006
38
CARD15 gene variants in aggressive periodontitis. (16965521)
2006
39
Functional gene polymorphisms in aggressive and chronic periodontitis. (16304445)
2005
40
Interdisciplinary treatment of a patient with severe pathologic tooth migration caused by localized aggressive periodontitis. (15775955)
2005
41
Gingival crevicular fluid levels of monocyte chemoattractant protein-1 and tumor necrosis factor-alpha in patients with chronic and aggressive periodontitis. (16274303)
2005
42
Simultaneous measurements of cytoplasmic Ca2+ responses and intracellular pH in neutrophils of localized aggressive periodontitis (LAP) patients. (15937144)
2005
43
Characterization of Actinobacillus actinomycetemcomitans isolated from young Chinese aggressive periodontitis patients. (15853973)
2005
44
Infection patterns in chronic and aggressive periodontitis. (16174268)
2005
45
Localized aggressive periodontitis in a six-year-old: a case report. (15344629)
2004
46
Telomere length in leukocytes and cultured gingival fibroblasts from patients with aggressive periodontitis. (15025219)
2004
47
Localized aggressive periodontitis is linked to human chromosome 1q25. (14673644)
2004
48
Neutrophil-mediated tissue injury in periodontal disease pathogenesis: findings from localized aggressive periodontitis. (12593599)
2003
49
Salivary IgA subclasses and bacteria-reactive IgA in patients with aggressive periodontitis. (12366855)
2002
50
Parameter on aggressive periodontitis. American Academy of Periodontology. (10875695)
2000

Genetic Variations for Aggressive Periodontitis

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Expression for genes affiliated with Aggressive Periodontitis

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1BioGPS, 15Gene Expression Omnibus DataSets
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Expression patterns in normal tissues for genes affiliated with Aggressive Periodontitis

Search GEO for disease gene expression data for Aggressive Periodontitis.

Pathways for genes affiliated with Aggressive Periodontitis

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29KEGG, 51QIAGEN, 37NCBI BioSystems Database
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Pathways related to Aggressive Periodontitis according to GeneCards/GeneDecks:

idSuper pathways (with members indented)ScoreTop Affiliating Genes
110.5FCGR2A, FCGR3B, FPR1
210.5FCGR2A, FCGR3B, IL1A
310.5FCGR3B, FCGR2A, FCER1A
4
Hide members
10.4MMP26, MMP25, MMP12
5
Hide members
10.4FCER1A, FCGR2A, FCGR3B, MMP26, MMP12

Compounds for genes affiliated with Aggressive Periodontitis

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44Novoseek, 49PharmGKB, 11DrugBank, 59Tocris Bioscience, 24HMDB, 28IUPHAR
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Compounds related to Aggressive Periodontitis according to GeneCards/GeneDecks:

(show all 47)
idCompoundScoreTop Affiliating Genes
1etanercept44 49 1112.9FCGR2A, FCGR3B, MMP12, IL1RN
2adalimumab44 49 1112.9IL1RN, FCGR3B, FCGR2A
3fmlp4410.9FCGR2A, FCGR3B, FPR1, IL1A, IL1RN
4n-formylmethionyl-leucylphenylalanine4410.9DGKQ, IL1A, FPR1, FCGR3B
5leukotriene b444 59 2412.9IL1RN, IL1A, FPR1, FCGR3B
62-chloroethyl ethyl sulfide4410.9IL1RN, IL1A
7uk 3833675910.9MMP12, MMP25, MMP26
8polymyxin b4410.9DEFB1, IL1RN, IL1A
9gi 254023x5910.9MMP12, MMP25, MMP26
10gm 60015910.9MMP12, MMP25, MMP26
11histamine44 28 2412.9DGKQ, CTSC, IL1RN, FPR1, FCGR2A, FCER1A
12cellulose triacetate4410.8IL1RN, IL1A
13marimastat44 59 1112.8MMP26, MMP25, MMP12
14h2o24410.8FCGR2A, FCGR3B, FPR1, IL1A, IL1RN, DGKQ
15pentoxifylline44 1111.8FPR1, IL1RN
16ivig4410.8IL1RN, IL1A, FCGR2A
17batimastat44 59 1112.8MMP26, MMP25, MMP12
18rantes4410.8FPR1, IL1A
19phosphoinositide4410.8DGKQ, DGKA, FPR1, FCGR3B, FCGR2A
20Palivizumab1110.8FCGR3B, FCGR2A
21nacl4410.8FPR1, IL1RN, DEFB1, DGKQ
22lipid4410.8DGKQ, DGKA, CD1A, IL1RN, FPR1, MMP12
23phosphatidylinositol4410.8DGKQ, IL1RN, FPR1, MMP12, FCGR3B, FCGR2A
24heparin44 28 11 2413.8CTSC, IL1RN, IL1A, FPR1, FCGR2A
25Intravenous Immunoglobulin1110.8FCGR3B, FCGR2A
26serine4410.8DGKQ, CTSC, IL1RN, IL1A, FPR1, MMP12
27tositumomab49 1111.8FCGR2A, FCGR3B
28calcium44 49 11 2413.8DGKQ, DGKA, DMP1, IL1RN, FPR1, MMP12
29bevacizumab49 1111.8FCGR2A, FCGR3B
30octyl glucoside4410.8DGKQ, FPR1
31dioctanoylglycol5910.8DGKQ, DGKA
32Ibritumomab1110.8FCGR2A, FCGR3B
33alefacept44 1111.8FCGR2A, FCGR3B
34vitamin-e4410.7DGKQ, IL1RN, MMP12
35Muromonab1110.7FCGR3B, FCGR2A
36efalizumab44 1111.7FCGR3B, FCGR2A
37fibrinogen4410.7MMP26, MMP12, FPR1, IL1RN
38daclizumab44 1111.7FCGR3B, FCGR2A
39sodium dodecylsulfate4410.7IL1A, IL1RN, DGKQ
40gold sodium thiomalate4410.6IL1A, IL1RN
41basiliximab44 1111.6FCGR2A, FCGR3B
42gemtuzumab ozogamicin44 1111.6FCGR3B, FCGR2A
43prednisolone44 28 1112.5FCGR2A, FCGR3B, IL1RN
44natalizumab44 1111.5FCGR3B, FCGR2A
45tyrosine4410.4FCGR2A, FCGR3B, MMP12, FPR1, IL1RN, DGKA
46alemtuzumab44 1111.4FCGR3B, FCGR2A
47dexamethasone44 49 28 1113.1DEFB1, IL1RN, IL1A, FPR1, MMP12

GO Terms for genes affiliated with Aggressive Periodontitis

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16Gene Ontology
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Cellular components related to Aggressive Periodontitis according to GeneCards/GeneDecks:

idNameGO IDScoreTop Affiliating Genes
1proteinaceous extracellular matrixGO:00557810.4MMP26, MMP25, MMP12, DMP1

Biological processes related to Aggressive Periodontitis according to GeneCards/GeneDecks:

idNameGO IDScoreTop Affiliating Genes
1immune responseGO:00695510.4FCGR3B, IL1A, IL1RN, CD1A, DEFB1, CTSC

Molecular functions related to Aggressive Periodontitis according to GeneCards/GeneDecks:

idNameGO IDScoreTop Affiliating Genes
1IgG bindingGO:01986410.5FCGR2A, FCGR3B
2interleukin-1 receptor bindingGO:00514910.5IL1A, IL1RN
3NAD+ kinase activityGO:00395110.4DGKA, DGKQ
4metalloendopeptidase activityGO:00422210.3MMP12, MMP25, MMP26
5diacylglycerol kinase activityGO:00414310.1DGKA, DGKQ

Products for genes affiliated with Aggressive Periodontitis

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  • Antibodies
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Sources for Aggressive Periodontitis

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3CDC
13ExPASy
14FMA
22GTR
23HGMD
24HMDB
25ICD10
26ICD10 via Orphanet
27ICD9CM
28IUPHAR
29KEGG
34MeSH
35MESH via Orphanet
36MGI
39NCIt
40NDF-RT
43NINDS
44Novoseek
46OMIM
47OMIM via Orphanet
50PubMed
51QIAGEN
57SNOMED-CT via Orphanet
60UMLS
61UMLS via Orphanet