MCID: AGG001
MIFTS: 47

Aggressive Periodontitis malady

Oral diseases category

Summaries for Aggressive Periodontitis

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Disease Ontology:9 A periodontitis that is characterized by rapid attachment loss and bone destruction in the presence of little local factors such as dental plaque and dental calculus resulting in inflammation and a loss of periodontium.

MalaCards based summary: Aggressive Periodontitis, also known as periodontitis, juvenile, is related to periodontitis and gingivitis. An important gene associated with Aggressive Periodontitis is FCGR3B (Fc fragment of IgG, low affinity IIIb, receptor (CD16b)), and among its related pathways are Fc-GammaR Pathway and Tuberculosis. The compounds tositumomab and ibritumomab have been mentioned in the context of this disorder. Affiliated tissues include bone, neutrophil and monocytes, and related mouse phenotypes are hematopoietic system and immune system.

Wikipedia:64 Aggressive periodontitis describes a type of periodontal disease and includes two of the seven... more...

Descriptions from OMIM:46 170650,608526

Aliases & Classifications for Aggressive Periodontitis

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Sources:
9Disease Ontology, 11DISEASES, 61UMLS, 44Novoseek, 56SNOMED-CT, 34MeSH, 46OMIM
See all sources

Aggressive Periodontitis, Aliases & Descriptions:

Name: Aggressive Periodontitis 9 11 61
Periodontitis, Juvenile 61
 
Periodontitis Juvenile 44
Juvenile Periodontitis 9


Classifications:

Malacards categories (disease lists): (See all malacards categories)
Anatomical: Oral diseases


External Ids:

Disease Ontology9 DOID:1474
MeSH34 D010520
SNOMED-CT56 2624008, 49965002

Related Diseases for Aggressive Periodontitis

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Diseases in the Aggressive Periodontitis family:

Periodontitis, Aggressive, 2

Diseases related to Aggressive Periodontitis via text searches within MalaCards or GeneCards/GeneDecks gene sharing:

(show all 40)
idRelated DiseaseScoreTop Affiliating Genes
1periodontitis32.1IL1A, MMP8, DEFB1
2gingivitis31.5IL1A, MMP8
3periodontal disease30.8DEFB1, MMP8, IL1A
4arthritis30.4FCGR2A, FCGR3B, MMP8, IL1A
5rheumatoid arthritis30.2FCGR2A, FCGR3B, MMP8, IL1A
6sarcoidosis30.1IL1A, DEFB1
7periodontosis10.7
8fibromatosis10.4
9tonsillitis10.4IL1A
10malaria10.4FCGR2A
11diabetes mellitus10.3
12type 1 diabetes mellitus10.3
13periapical granuloma10.3MMP8
14periodontitis 1, juvenile10.2
15blindness10.2
16neutropenia10.2FPR1, FCGR3B
17peritonitis10.1MMP8, FCGR3B
18nephritis10.1FCGR2A, FCGR3B
19systemic lupus erythematosus10.1FCGR3B, FCGR2A
20amelogenesis imperfecta10.1
21ectodermal dysplasia10.1
22fanconi's anemia10.1
23giant cell reparative granuloma10.1
24cutaneous lupus erythematosus10.1
25rickets10.1
26dental caries10.1
27lupus erythematosus10.1
28dentinogenesis imperfecta10.1
29tooth agenesis10.1
30pierre robin sequence10.1
31pustulosis palmaris et plantaris10.1
32synovitis10.0IL1A, MMP8
33cholesteatoma10.0IL1A, MMP8, DEFB1
34hypersensitivity reaction type ii disease10.0FCGR2A, FCGR3B, IL1A
35osteoarthritis10.0FCGR3B, MMP8, IL1A
36leukemia9.9FPR1, IL1A, FCGR3B, CYBA
37ipex syndrome9.9FPR1, MMP8, FCGR3B, FCGR2A
38sepsis9.8DEFB1, FCGR2A, FCGR3B, IL1A, FPR1
39atherosclerosis9.7CYBA, FCGR2A, MMP8, IL1A
40asthma9.7DEFB1, FCGR3B, FCER1A, MMP8

Graphical network of the top 20 diseases related to Aggressive Periodontitis:



Diseases related to aggressive periodontitis

Symptoms for Aggressive Periodontitis

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Clinical features from OMIM:

170650,608526

Drugs & Therapeutics for Aggressive Periodontitis

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Drug clinical trials:

Search ClinicalTrials for Aggressive Periodontitis

Search NIH Clinical Center for Aggressive Periodontitis

Genetic Tests for Aggressive Periodontitis

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Anatomical Context for Aggressive Periodontitis

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MalaCards organs/tissues related to Aggressive Periodontitis:

32
Bone, Neutrophil, Monocytes, Whole blood, Colon, T cells

Animal Models for Aggressive Periodontitis or affiliated genes

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MGI Mouse Phenotypes related to Aggressive Periodontitis:

36
idDescriptionMGI Source AccessionScoreTop Affiliating Genes
1MP:00053977.9FPR1, IL1A, FCER1A, FCGR2A, CYBA
2MP:00053876.7FPR1, DEFB1, CYBA, FCGR2A, FCER1A, MMP8

Publications for Aggressive Periodontitis

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Articles related to Aggressive Periodontitis:

(show top 50)    (show all 469)
idTitleAuthorsYear
1
The novel role of HtrA1 in gingivitis, chronic and aggressive periodontitis. (24979214)
2014
2
Investigation of dental pulp stem cells isolated from discarded human teeth extracted due to aggressive periodontitis. (25172527)
2014
3
Clinical and Microbiological Effects of Photodynamic Therapy Associated with Non-surgical Treatment in Aggressive Periodontitis. (25346834)
2014
4
Clinical and radiographic evaluation of intra-bony defects in localized aggressive periodontitis patients with platelet rich plasma/hydroxyapatite graft: A comparative controlled clinical trial. (25395757)
2014
5
Correlation of Aggregatibacter actinomycetemcomitans Detection with Clinical/Immunoinflammatory Profile of Localized Aggressive Periodontitis Using a 16S rRNA Microarray Method: A Cross-Sectional Study. (24376864)
2013
6
Bimaxillary unilateral gingival fibromatosis with localized aggressive periodontitis (eating the tooth at the same table). (24124307)
2013
7
Aggressive periodontitis diagnosed during or before orthodontic treatment. (23210838)
2013
8
Template-guided flapless implant insertion and prosthetic rehabilitation with telescopic crowns in a patient with treated generalized aggressive periodontitis: a case report. (22299117)
2012
9
Generalized aggressive periodontitis and its treatment options: case reports and review of the literature. (22291715)
2012
10
Microbiological characterization in children with aggressive periodontitis. (22863892)
2012
11
Treatment of generalised aggressive periodontitis: a 4-year follow-up case report. (22866285)
2012
12
A combination of clinical and microbiological management of generalized aggressive periodontitis in primary teeth. A case report. (22066568)
2012
13
Antimicrobial photodynamic therapy in the non-surgical treatment of aggressive periodontitis: microbiological profile. (21399951)
2012
14
Detection of human herpes viruses in patients with chronic and aggressive periodontitis and relationship between viruses and clinical parameters. (22923891)
2012
15
Prevalence of Aggregatibacter actinomycetemcomitans in Sudanese patients with aggressive periodontitis: a case-control study. (21332472)
2011
16
Report of a case of Turner's syndrome with localized aggressive periodontitis. (21976844)
2011
17
Genetic study of families affected with aggressive periodontitis. (21501238)
2011
18
The clinical assessment of aggressive periodontitis patients. (21811690)
2011
19
Local inflammatory markers and systemic endotoxin in aggressive periodontitis. (21730256)
2011
20
Volumetric analysis of intrabony defects in aggressive periodontitis patients following use of a novel composite alloplast: a pilot study. (21519556)
2011
21
Amoxicillin and metronidazole as an adjunctive treatment in generalized aggressive periodontitis at initial therapy or re-treatment: a randomized controlled clinical trial. (21062335)
2011
22
Investigation of the interleukin-1 gene cluster polymorphisms in Jordanian patients with chronic and aggressive periodontitis. (21035110)
2011
23
Response of chronic and aggressive periodontitis to treatment. (20403111)
2010
24
Genetic power of a Brazilian three-generation family with generalized aggressive periodontitis. (20640360)
2010
25
IL-1 gene cluster is not linked to aggressive periodontitis. (20335539)
2010
26
Eosinophilic granuloma or aggressive periodontitis?]. (20074763)
2010
27
Histopathological features of chronic and aggressive periodontitis. (20403104)
2010
28
Immunologic and microbiologic profiles of chronic and aggressive periodontitis subjects. (20450404)
2010
29
Unusual gingival enlargement with aggressive periodontitis: a case report. (20461324)
2010
30
FBAT analysis of polymorphisms of vitamin D receptor (Taq I and Fok I) in aggressive periodontitis families]. (20140038)
2010
31
Aggressive periodontitis and chronic arthritis: blood mononuclear cell gene expression and plasma protein levels of cytokines and cytokine inhibitors. (19186969)
2009
32
Ceruloplasmin induces polymorphonuclear leukocyte priming in localized aggressive periodontitis. (19656030)
2009
33
Relationship of neutrophil phagocytosis and oxidative burst with the subgingival microbiota of generalized aggressive periodontitis. (19239639)
2009
34
Risk of aggressive periodontitis in adolescent carriers of the JP2 clone of Aggregatibacter (Actinobacillus) actinomycetemcomitans in Morocco: a prospective longitudinal cohort study. (18207019)
2008
35
Interleukin-1 and tumor necrosis factor-alpha gene polymorphisms in Turkish patients with localized aggressive periodontitis. (18587204)
2008
36
Association of vitamin D receptor gene polymorphisms in Chinese patients with generalized aggressive periodontitis. (18205735)
2008
37
Platelet-rich plasma in combination with bovine derived xenograft in the treatment of generalized aggressive periodontitis: a case report with re-entry. (17957570)
2007
38
Aggregatibacter actinomycetemcomitans as indicator for aggressive periodontitis by two analysing strategies. (17433043)
2007
39
Timing affects the clinical outcome of adjunctive systemic antibiotic therapy for generalized aggressive periodontitis. (17608574)
2007
40
Demographic, clinical, and microbial aspects of chronic and aggressive periodontitis in Colombia: a multicenter study. (17397309)
2007
41
Incomplete adherence to an adjunctive systemic antibiotic regimen decreases clinical outcomes in generalized aggressive periodontitis patients: a pilot retrospective study. (17711478)
2007
42
Expressions of selected adhesion molecules on peripheral blood leukocytes in patients with aggressive periodontitis. (15995587)
2005
43
Cytokine profile in gingival crevicular fluid of aggressive periodontitis: influence of smoking and stress. (15367195)
2004
44
The -308 polymorphism in the promoter region of the tumor necrosis factor-alpha (TNF-alpha) gene and ex vivo lipopolysaccharide-induced TNF-alpha expression in patients with aggressive periodontitis and/or type 1 diabetes mellitus. (15627647)
2004
45
Aggressive periodontitis of the primary dentition associated with idiopathic immune deficiency: case report and treatment considerations. (15554399)
2004
46
Clinical and radiographic evaluation of Emdogain as a regenerative material in the treatment of interproximal vertical defects in chronic and aggressive periodontitis patients. (15119889)
2004
47
Identification of mRNAs for the various diacylglycerol kinase isoforms in neutrophils from patients with localized aggressive periodontitis. (12941073)
2003
48
Distribution of periodontal pathogens in Korean aggressive periodontitis. (14584866)
2003
49
Lactoferrin iron levels are reduced in saliva of patients with localized aggressive periodontitis. (12083535)
2002
50
Differential gene expression in neutrophils from patients with generalized aggressive periodontitis. (11762875)
2001

Variations for Aggressive Periodontitis

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Expression for genes affiliated with Aggressive Periodontitis

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Expression patterns in normal tissues for genes affiliated with Aggressive Periodontitis

Search GEO for disease gene expression data for Aggressive Periodontitis.

Pathways for genes affiliated with Aggressive Periodontitis

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Compounds for genes affiliated with Aggressive Periodontitis

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Compounds related to Aggressive Periodontitis according to GeneCards/GeneDecks:

(show top 50)    (show all 51)
idCompoundScoreTop Affiliating Genes
1tositumomab50 1211.1FCGR2A, FCGR3B
2ibritumomab50 1211.1FCGR3B, FCGR2A
3alefacept44 1211.1FCGR3B, FCGR2A
4bevacizumab50 1211.1FCGR3B, FCGR2A
5efalizumab44 1211.1FCGR2A, FCGR3B
6cytochalasin b4410.1FPR1, FCGR3B
7daclizumab44 1211.1FCGR2A, FCGR3B
8basiliximab44 1211.1FCGR3B, FCGR2A
9natalizumab44 1211.1FCGR2A, FCGR3B
10alemtuzumab44 1211.1FCGR2A, FCGR3B
11gemtuzumab ozogamicin50 44 1212.1FCGR3B, FCGR2A
12adalimumab44 50 1212.1FCGR3B, FCGR2A
13ciprofloxacin44 50 1212.1IL1A, DEFB1
14abciximab44 1211.0FCGR3B, FCGR2A
15polymyxin b4410.0IL1A, DEFB1
16cetuximab44 50 1212.0FCGR3B, FCGR2A
17etanercept44 50 1212.0FCGR2A, FCGR3B
18pentoxifylline44 1210.9FPR1, IL1A
19leukotriene b444 60 2511.9FPR1, IL1A, FCGR3B
20ivig449.9IL1A, FCGR2A
21trastuzumab44 50 1211.8FCGR3B, FCGR2A
22rantes449.8DEFB1, IL1A, FPR1
23rituximab44 50 1211.7FCGR2A, FCGR3B
24hocl449.7MMP8, CYBA
25phosphoinositide449.7FCGR2A, FCGR3B, FPR1
26fluvastatin44 50 29 1212.6IL1A, CYBA
27mannose449.6FCAR, FCGR3B, FCGR2A
28dbc-amp449.6FPR1, FCGR3B
29tetracycline44 1210.4IL1A, MMP8
30fmlp449.4FCGR2A, FCGR3B, IL1A, FPR1
31n-formylmethionyl-leucylphenylalanine449.4FPR1, IL1A, FCGR3B, CYBA
32cyclosporin a44 29 6011.3FPR1, IL1A, MMP8
33nadph44 2510.3CYBA, FCGR2A, FCGR3B, FPR1
34pge2449.3FPR1, IL1A, MMP8
35glutamine449.3CYBA, FCGR2A, IL1A
36genistein44 29 60 3 25 1214.3FPR1, IL1A, MMP8, FCGR3B
37dexamethasone44 50 29 1212.2FPR1, IL1A, CYBA, DEFB1
38arachidonic acid44 29 25 1212.2CYBA, FCGR2A, IL1A, FPR1
39heparin44 29 25 1212.2FPR1, IL1A, FCGR2A
40histamine44 29 2511.2FCGR2A, FCER1A, FPR1
41retinoic acid44 2510.1FPR1, IL1A, MMP8, DEFB1
42nitric oxide44 25 1210.9FPR1, IL1A, MMP8, CYBA
43oligonucleotide448.9CYBA, FCGR2A, MMP8, FPR1
44tyrosine448.7CYBA, FCGR2A, FCGR3B, FCAR, FPR1
45lipid448.7CYBA, FCGR2A, FCGR3B, MMP8, FPR1
46superoxide44 259.6CYBA, FCGR3B, FCAR, MMP8, FPR1
47oxygen44 259.5CYBA, FCGR2A, FCAR, MMP8, FPR1
48calcium44 50 25 1211.3DMP1, CYBA, FCGR2A, FCGR3B, MMP8, FPR1
49h2o2448.3CYBA, FCGR2A, FCGR3B, MMP8, IL1A, FPR1
50serine448.3FCGR2A, FCGR3B, FCAR, MMP8, IL1A, FPR1

GO Terms for genes affiliated with Aggressive Periodontitis

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Cellular components related to Aggressive Periodontitis according to GeneCards/GeneDecks:

idNameGO IDScoreTop Affiliating Genes
1extracellular regionGO:0055767.9IL1A, MMP8, FCAR, FCGR3B, DMP1, DEFB1

Biological processes related to Aggressive Periodontitis according to GeneCards/GeneDecks:

idNameGO IDScoreTop Affiliating Genes
1immune responseGO:0069558.6IL1A, FCAR, FCGR3B, DEFB1
2innate immune responseGO:0450878.3FCER1A, FCGR2A, CYBA, DEFB1

Molecular functions related to Aggressive Periodontitis according to GeneCards/GeneDecks:

idNameGO IDScoreTop Affiliating Genes
1IgG bindingGO:0198649.7FCGR3B, FCGR2A

Products for genes affiliated with Aggressive Periodontitis

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Sources for Aggressive Periodontitis

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4CDC
14ExPASy
15FMA
23GTR
24HGMD
25HMDB
26ICD10
27ICD10 via Orphanet
28ICD9CM
29IUPHAR
30KEGG
34MeSH
35MESH via Orphanet
36MGI
39NCIt
40NDF-RT
43NINDS
44Novoseek
46OMIM
47OMIM via Orphanet
51PubMed
52QIAGEN
57SNOMED-CT via Orphanet
61UMLS
62UMLS via Orphanet