Aliases & Classifications for Aging

MalaCards integrated aliases for Aging:

Name: Aging 53 72 3

External Ids:

OMIM 53 502000

Summaries for Aging

OMIM : 53 Progressive damage to mitochondrial DNA (mtDNA) during life is thought to contribute to aging processes. This notion is supported by the observation of an aging-related accumulation in human mtDNA of oxidative and alkylation derivatives of nucleotides, of small deletions and insertions, and of large deletions, although their low frequency raises questions about their functional significance (Michikawa et al., 1999). (502000)

MalaCards based summary : Aging is related to werner syndrome and atypical werner syndrome. An important gene associated with Aging is LMNA (Lamin A/C), and among its related pathways/superpathways are Endometrial cancer and TNFR1 Pathway. The drugs Acetylcholine and Dopamine have been mentioned in the context of this disorder. Affiliated tissues include brain, bone and heart, and related phenotypes are Decreased viability and Decreased viability

Wikipedia : 72 Senescence (/sɪˈnɛsəns/) or biological aging (also spelled biological ageing) is the gradual... more...

Related Diseases for Aging

Diseases related to Aging via text searches within MalaCards or GeneCards Suite gene sharing:

(show top 50) (show all 3470)
# Related Disease Score Top Affiliating Genes
1 werner syndrome 33.0 LMNA PARP1 WRN
2 atypical werner syndrome 31.8 LMNA WRN
3 leukemia, acute myeloid 31.3 AKT1 JUN PARP1 SNCA TP53
4 esophageal cancer 31.1 AKT1 HIF1A JUN TGFBR2 TP53
5 pancreatic cancer 30.8 AKT1 HIF1A PARP1 PDGFRB TGFBR2 TP53
6 adenocarcinoma 30.3 AKT1 PDGFRB TGFBR2 TP53
7 glioblastoma 30.0 AKT1 HIF1A PDGFRB TP53
8 arteriosclerosis 30.0 IL10 KL PPARG SERPINE1
9 vascular disease 29.9 NAMPT PPARG SERPINE1 SOD1
10 overnutrition 29.9 NAMPT PPARG SERPINE1
11 cervical cancer 29.5 HIF1A PARP1 TP53 TP63
12 glioblastoma multiforme 29.4 AKT1 HIF1A PDGFRB PPARG TP53
13 glucose metabolism disease 29.4 AKT1 PPARG SERPINE1
14 nasopharyngeal carcinoma 29.3 AKT1 HIF1A JUN PARP1 TGFBR2 TP53
15 tetraploidy 29.0 PARP1 TP53
16 ewing sarcoma 28.8 AKT1 HIF1A JUN PARP1 PDGFRB TGFBR2
17 lung cancer 28.8 AKT1 HIF1A JUN PARP1 PDGFRB PPARG
18 diabetes mellitus, noninsulin-dependent 28.6 AKT1 LMNA NAMPT PPARG SERPINE1 SIRT1
19 macular degeneration, age-related, 1 12.4
20 macular degeneration, age-related, 10 12.2
21 age-related hearing loss 12.1
22 premature aging syndrome, penttinen type 12.1
23 neuropathy, hereditary, with or without age-related macular degeneration 12.1
24 macular degeneration, age-related, 5 12.1
25 macular degeneration, age-related, 13 12.1
26 macular degeneration, age-related, 2 12.1
27 macular degeneration, age-related, 7 12.1
28 macular degeneration, age-related, 8 12.1
29 macular degeneration, age-related, 4 12.1
30 macular degeneration, age-related, 9 12.1
31 macular degeneration, age-related, 11 12.1
32 macular degeneration, age-related, 6 12.1
33 macular degeneration, age-related, 12 12.1
34 macular degeneration, age-related, 14 12.1
35 macular degeneration, age-related, 15 12.1
36 age-related hearing impairment 1 12.0
37 age-related hearing impairment 2 12.0
38 short stature and advanced bone age, with or without early-onset osteoarthritis and/or osteochondritis dissecans 11.9
39 menarche, age at, quantitative trait locus 1 11.9
40 menopause, natural, age at, quantitative trait locus 1 11.8
41 premature aging syndrome, okamoto type 11.8
42 menopause, natural, age at, quantitative trait locus 2 11.8
43 menopause, natural, age at, quantitative trait locus 4 11.8
44 macroepiphyseal dysplasia with osteoporosis, wrinkled skin, and aged appearance 11.8
45 cataract, age-related nuclear 11.8
46 creases, infra-auricular cutaneous, with tall stature and advanced bone age 11.7
47 menarche, age at, quantitative trait locus 2 11.7
48 menarche, age at, quantitative trait locus 3 11.7
49 dwarfism lethal type advanced bone age 11.7
50 gigantism advanced bone age hoarse cry 11.7

Graphical network of the top 20 diseases related to Aging:



Diseases related to Aging

Symptoms & Phenotypes for Aging

Clinical features from OMIM:

502000

GenomeRNAi Phenotypes related to Aging according to GeneCards Suite gene sharing:

25
# Description GenomeRNAi Source Accession Score Top Affiliating Genes
1 Decreased viability GR00107-A-1 10.46 TGFBR2
2 Decreased viability GR00221-A-1 10.46 TGFBR2 AKT1 PDGFRB PPARG
3 Decreased viability GR00221-A-2 10.46 PPARG SOD1 AKT1 JUN
4 Decreased viability GR00221-A-3 10.46 PPARG SOD1 TGFBR2 AKT1 JUN PDGFRB
5 Decreased viability GR00221-A-4 10.46 SOD1 TGFBR2 AKT1 PDGFRB PPARG
6 Decreased viability GR00342-S-1 10.46 PDGFRB
7 Synthetic lethal with MLN4924 (a NAE inhibitor) GR00250-A-1 9.84 AKT1 HIF1A IL10 JUN SIRT1 SNCA
8 Synthetic lethal with MLN4924 (a NAE inhibitor) GR00250-A-2 9.84 AKT1 HIF1A IL10 JUN SIRT1 SNCA
9 Increased viability with MLN4924 (a NAE inhibitor) GR00250-A-3 9.56 HIF1A JUN PARP1 SIRT1 SOD1 TP53

MGI Mouse Phenotypes related to Aging:

43 (show all 27)
# Description MGI Source Accession Score Top Affiliating Genes
1 cardiovascular system MP:0005385 10.6 SERPINE1 SIRT1 SNCA SOD1 SOD2 TGFBR2
2 growth/size/body region MP:0005378 10.58 TP63 WRN HIF1A IL10 JUN KL
3 cellular MP:0005384 10.57 TP53 TP63 WRN AKT1 HIF1A IL10
4 behavior/neurological MP:0005386 10.56 SOD1 SOD2 TGFBR2 TP53 TP63 AKT1
5 homeostasis/metabolism MP:0005376 10.56 IL10 JUN KL LMNA NAMPT PARP1
6 immune system MP:0005387 10.53 AKT1 HIF1A IL10 JUN KL LMNA
7 integument MP:0010771 10.51 AKT1 HIF1A IL10 JUN KL LMNA
8 hematopoietic system MP:0005397 10.5 SOD2 TGFBR2 AKT1 HIF1A IL10 JUN
9 endocrine/exocrine gland MP:0005379 10.49 JUN KL AKT1 HIF1A IL10 LMNA
10 mortality/aging MP:0010768 10.49 AKT1 HIF1A IL10 JUN KL LMNA
11 adipose tissue MP:0005375 10.41 AKT1 KL LMNA PDGFRB PPARG RGN
12 embryo MP:0005380 10.38 IL10 AKT1 HIF1A JUN NAMPT PARP1
13 liver/biliary system MP:0005370 10.36 KL LMNA PPARG RGN SERPINE1 SIRT1
14 nervous system MP:0003631 10.36 AKT1 HIF1A IL10 JUN KL LMNA
15 digestive/alimentary MP:0005381 10.35 HIF1A IL10 KL LMNA PDGFRB SIRT1
16 craniofacial MP:0005382 10.31 HIF1A IL10 KL LMNA PDGFRB SIRT1
17 muscle MP:0005369 10.26 AKT1 HIF1A IL10 KL LMNA PDGFRB
18 hearing/vestibular/ear MP:0005377 10.23 SOD1 SOD2 TP53 KL LMNA PARP1
19 neoplasm MP:0002006 10.23 AKT1 HIF1A IL10 PPARG SERPINE1 SIRT1
20 limbs/digits/tail MP:0005371 10.18 HIF1A IL10 KL LMNA PDGFRB SIRT1
21 normal MP:0002873 10.15 AKT1 HIF1A IL10 JUN LMNA PDGFRB
22 renal/urinary system MP:0005367 10.1 SNCA SOD2 TP53 TP63 SIRT1 HIF1A
23 reproductive system MP:0005389 10.1 AKT1 IL10 KL LMNA PARP1 PDGFRB
24 no phenotypic analysis MP:0003012 10.01 IL10 JUN PARP1 PPARG SIRT1 SNCA
25 respiratory system MP:0005388 9.93 TGFBR2 TP53 TP63 AKT1 HIF1A IL10
26 skeleton MP:0005390 9.86 AKT1 HIF1A IL10 JUN KL LMNA
27 vision/eye MP:0005391 9.53 SIRT1 SOD1 SOD2 TGFBR2 TP53 TP63

Drugs & Therapeutics for Aging

Drugs for Aging (from DrugBank, HMDB, Dgidb, PharmGKB, IUPHAR, NovoSeek, BitterDB):

(show top 50) (show all 866)
# Name Status Phase Clinical Trials Cas Number PubChem Id
1
Acetylcholine Approved Phase 4,Phase 3,Phase 2,Phase 1 51-84-3 187
2
Dopamine Approved Phase 4,Phase 3,Phase 2 51-61-6, 62-31-7 681
3
Methylphenidate Approved, Investigational Phase 4,Phase 3,Phase 2 20748-11-2, 113-45-1 4158
4
Dexmedetomidine Approved, Vet_approved Phase 4,Phase 2,Phase 3 76631-46-4, 113775-47-6 5311068 56032 68602
5
Propofol Approved, Investigational, Vet_approved Phase 4 2078-54-8 4943
6
Aspirin Approved, Vet_approved Phase 4,Phase 3 50-78-2 2244
7
Clopidogrel Approved Phase 4,Phase 3 120202-66-6, 113665-84-2 60606
8
Pantoprazole Approved Phase 4 102625-70-7 4679
9
Ticlopidine Approved Phase 4,Phase 3 55142-85-3 5472
10
Digoxin Approved Phase 4 20830-75-5 2724385 30322
11
Cobicistat Approved Phase 4 1004316-88-4
12
Darunavir Approved Phase 4 635728-49-3, 206361-99-1 213039
13
Rilpivirine Approved Phase 4 500287-72-9
14
Hyaluronic acid Approved, Vet_approved Phase 4,Phase 3,Phase 2,Phase 1 9004-61-9 53477741 24759
15
Medroxyprogesterone acetate Approved, Investigational Phase 4,Phase 3,Phase 2 71-58-9
16
Levobupivacaine Approved, Investigational Phase 4 27262-47-1 92253
17
Methyltestosterone Approved Phase 4,Phase 3,Phase 2,Phase 1,Early Phase 1 58-18-4 6010
18
Testosterone Approved, Investigational Phase 4,Phase 3,Phase 2,Phase 1,Early Phase 1 58-22-0 6013
19
Donepezil Approved Phase 4,Phase 3,Phase 2,Phase 1 120014-06-4 3152
20
Hydrocortisone Approved, Vet_approved Phase 4,Phase 2,Phase 1 50-23-7 657311 5754
21
Isoflurane Approved, Vet_approved Phase 4 26675-46-7 3763
22
Sevoflurane Approved, Vet_approved Phase 4 28523-86-6 5206
23
Benzocaine Approved, Investigational Phase 4,Phase 3,Phase 2,Phase 1 1994-09-7, 94-09-7 2337
24
Lidocaine Approved, Vet_approved Phase 4,Phase 3,Phase 2,Early Phase 1 137-58-6 3676
25
Triamcinolone Approved, Vet_approved Phase 4,Phase 2 124-94-7 31307
26
Celecoxib Approved, Investigational Phase 4,Phase 3 169590-42-5 2662
27
Ibuprofen Approved Phase 4,Phase 3,Phase 1 15687-27-1 3672
28
Armodafinil Approved, Investigational Phase 4,Phase 2 112111-43-0
29
Modafinil Approved, Investigational Phase 4,Phase 2 68693-11-8 4236
30
Naproxen Approved, Vet_approved Phase 4,Phase 2,Phase 3 22204-53-1 156391 1302
31
Dexamethasone Approved, Investigational, Vet_approved Phase 4,Phase 2 50-02-2 5743
32
Estradiol Approved, Investigational, Vet_approved Phase 4,Phase 2,Phase 3,Phase 1,Early Phase 1 50-28-2 5757
33
Zinc Approved, Investigational Phase 4,Phase 3,Phase 2,Phase 1 7440-66-6 32051 23994
34
Mannitol Approved, Investigational Phase 4,Phase 1,Phase 2 69-65-8 6251 453
35
Loperamide Approved Phase 4 53179-11-6 3955
36
Pectin Approved, Vet_approved Phase 4 9000-69-5 441476
37
Citalopram Approved Phase 4,Phase 3 59729-33-8 2771
38
Metformin Approved Phase 4,Phase 3,Phase 2,Phase 1,Early Phase 1 657-24-9 4091 14219
39
Pravastatin Approved Phase 4,Phase 3 81093-37-0 54687
40
Simvastatin Approved Phase 4,Phase 3,Phase 2 79902-63-9 54454
41
Pioglitazone Approved, Investigational Phase 4,Phase 3,Phase 2 111025-46-8 4829
42
Abacavir Approved, Investigational Phase 4,Phase 3 136470-78-5 441300 65140
43 Dolutegravir Approved Phase 4,Phase 3 1051375-16-6 54726191
44
Lamivudine Approved, Investigational Phase 4,Phase 3 134678-17-4 60825
45
Desflurane Approved Phase 4 57041-67-5 42113
46
Ethanol Approved Phase 4,Phase 3,Phase 2,Early Phase 1 64-17-5 702
47
Kinetin Approved Phase 4 525-79-1 3830
48
Polidocanol Approved Phase 4 9002-92-0
49
Chlorhexidine Approved, Vet_approved Phase 4,Phase 3,Phase 1 55-56-1 2713 9552079
50
Fentanyl Approved, Illicit, Investigational, Vet_approved Phase 4 437-38-7 3345

Interventional clinical trials:

(show top 50) (show all 3061)

# Name Status NCT ID Phase Drugs
1 Comparison of Escalating Doses of IncobotulinumtoxinA (Xeomin®) in the Treatment of Glabellar Rhytids Unknown status NCT01583478 Phase 4
2 Effects of Omega-3 Fatty Acids on Bone and Frailty Unknown status NCT00634686 Phase 4
3 Ritalin, Memory and Attention in MCI: a Behaviour-EEG Study Unknown status NCT02326038 Phase 4 Methylphenidate
4 Rosuvastatin Effect on Telomere-telomerase System in ACS Unknown status NCT02299245 Phase 4 rosuvastatin
5 Postoperative Recovery in Elderly Patients Undergoing Hip Hemi-arthroplasty Unknown status NCT01934049 Phase 4 Total Intravenous Anesthesia and Peripheral nerve blocks
6 Does Early Re-administration of Aspirin/Clopidogrel Increase the Risk of Bleeding From Artificial Ulcer After EMR or ESD? Unknown status NCT01621451 Phase 4 aspirin and/or clopidogrel;aspirin and/or clopidogrel
7 Marinobufagenin as a Target for DIGIBIND in Hypertensive Patients With End-stage Renal Disease Unknown status NCT00852787 Phase 4 Digoxin immune fab;Placebo
8 Open Label, Pilot Study of Darunavir Boosted by Cobicistat in Combination With Rilpivirine to Treat HIV+ Naïve Subjects Unknown status NCT02404233 Phase 4 darunavir/cobicistat;rilpivirine
9 The Effect of a Higher Dose of Dehydroepiandrosterone (DHEA) Supplementation in Poor Responders Unknown status NCT02357472 Phase 4 dehydroepiandrosterone
10 The Role Of FGF23, Klotho, And Sclerostin In Kidney Stone Formers Unknown status NCT01526304 Phase 4
11 The Impact of Hyaluronic Acid Injections on Osteoarthritic Knee Mechanics Unknown status NCT00778076 Phase 4
12 The Effects of Blood Pressure Reduction on Cerebral Perfusion and Cognition in the Elderly Population Unknown status NCT00966199 Phase 4 anti-hypertensive medication
13 Herbal Alternatives for Menopause Symptoms (HALT Study) Unknown status NCT00169299 Phase 4 Black cohosh;Multibotanical preparation;Multibotanical preparation + dietary soy counseling;Conjugated equine estrogen +/- medroxyprogesterone acetate
14 A Dose Finding Study for Pain Relief of a Broken Hip Unknown status NCT00926666 Phase 4 Levobupivacaine
15 Testosterone Replacement in Middle-Aged Hypogonadal Men With Dysthymia: Parallel Group, Double Blind Randomized Trial Unknown status NCT00260390 Phase 4 Testoviron
16 CALM-AD Unknown status NCT00142324 Phase 4 Donepezil
17 Volume Restoration of the Aging Midface With Sculptra Aesthetic Completed NCT01307865 Phase 4 injectable poly-L-lactic acid
18 Changing in Skin Physiology After Microdroplet Placement of Stabilized Hyaluronic Acid in Aging Faces Completed NCT02312154 Phase 4
19 Skin Aging in Renal Transplant Patients Completed NCT01776983 Phase 4
20 Age-Related Changes in Stress Hormone Regulation Completed NCT00018369 Phase 4
21 Pectin, Aging and Intestinal Barrier Function Completed NCT02376270 Phase 4
22 Brain Imaging and Mental Disorders of Aging Intervention Completed NCT00267163 Phase 4 donepezil;Placebo
23 PPV: Pneumococcal Polysaccharide Vaccine in Older Adults Completed NCT00239694 Phase 4
24 Canadian Aesthetic Experience With Sculptra Therapy Completed NCT00447551 Phase 4 Poly-L-Lactic Acid
25 Aging Brain Changes, Executive Dysfunction and Depression Completed NCT00918684 Phase 4 Escitalopram
26 Memory and Mental Health in Aging Completed NCT02988908 Phase 4 Donepezil;Placebos
27 Testosterone Effects on Bone and Frailty Completed NCT00182871 Phase 4 testosterone
28 The Effect of Luteinizing Hormone (LH) Supplementation Following Gonadotropin-releasing Hormone (GnRH) Antagonist Administration in Advanced Reproductive Ageing Women Undergoing IVF and Embryo Transfer (IVF/ET) Completed NCT01016210 Phase 4 Leuveris;Leuveris
29 Clinical Evaluation of Day and Night Skin Care Creams Supplemented With MediCell Technology (MCT)'s Composition of Defensins and Supportive Molecules Completed NCT02765763 Phase 4 2-Minute Reveal Masque;24/7 Barrier Repair Cream;8-in-1 BioSerum;Null Formula 2-Minute Reveal Masque;Null Formula 24/7 Barrier Repair Cream;Null Formula 8-in-1 BioSerum
30 Effect of a Transcutaneous Electrical Nerve Stimulation (TENS) Device on Overall Facial Appearance Completed NCT01740440 Phase 4
31 Comparative Study of the Effect of Dysport and Botox Completed NCT00434863 Phase 4 botulinum toxin type A
32 Poly-L-lactic Acid for Skin Quality Completed NCT02003833 Phase 4
33 Evaluation of Radiesse® Dermal Filler for Hand Rejuvenation Completed NCT01004107 Phase 4
34 Effects of a Proprietary Blend of Herbal Extract Supplement on Cellular Detoxification, Inflammation, and Cumulative Cognitive Index as Well as Gene Expression in Middle-Aged Adult Women Completed NCT01598272 Phase 4
35 Comparison of Outcome Parameters in Laser Rhytide Treatment Completed NCT00994474 Phase 4
36 Patient Satisfaction With Treatment of BOTOX® Cosmetic for the Temporary Correction of Moderate to Severe Glabellar Lines Completed NCT00856414 Phase 4
37 Comparative Study of Reconstituted JUVÉDERM® Ultra vs COSMODERM® 1 for Lip and Cheek Lines, Folds or Wrinkles Completed NCT01212809 Phase 4
38 Efficacy of Fenugreek Seed and Lespedeza Cuneata in TDS Completed NCT03057899 Phase 4 TFG capsules (200 mg /capsule);Placebo oral capsule
39 Metformin and Longevity Genes in Prediabetes Completed NCT01765946 Phase 4 Metformin;placebo
40 Do HMG CoA Reductase Inhibitors Affect Abeta Levels? Completed NCT00303277 Phase 4 simvastatin;pravastatin
41 Effect of Revival Soy on Weight Loss and Skin, Hair, and Nails in Premenopausal Women Completed NCT00352157 Phase 4
42 Onabotulinum Toxin Type A and Abobotulinum Toxin Type A Crow's Feet Rhytid Study Completed NCT01529788 Phase 4 Right lateral orbital injection of Botox Cosmetic or Dysport;Left lateral orbital injection of Botox Cosmetic or Dysport
43 ESPRIT Study in Hypogonadal Men Completed NCT01143818 Phase 4 AndroGel (testosterone gel) 1%
44 Study to Assess DerMend Moisturizing Bruise Formula in Improving the Appearance of Chronically Aged Forearms and Hands Completed NCT01910831 Phase 4 DerMend Moisturizing Bruise Formula
45 Anabolic and Inflammatory Responses to Short-Term Testosterone Administration in Older Men Completed NCT00957801 Phase 4 Testosterone injection;Testosterone gel
46 Zurich Multiple Endpoint Vitamin D Trial in Knee OA Patients Completed NCT00599807 Phase 4
47 Optimizing Body Composition for Function in Older Adults Completed NCT00315146 Phase 4 Pioglitazone;Placebo
48 Effects of DHEA/Exercise on Bone, Muscle and Balance Completed NCT00664053 Phase 4
49 Effect of an Alpha-linolenic Acid-rich Supplement on Ketogenesis and Plasma Fatty Acids Completed NCT02410161 Phase 4
50 Donepezil in Preventing Delirium in Hospitalized Elderly Completed NCT00182884 Phase 4 Donepezil

Search NIH Clinical Center for Aging

Genetic Tests for Aging

Anatomical Context for Aging

MalaCards organs/tissues related to Aging:

38
Brain, Bone, Heart, Skin, Breast, Endothelial, Eye

Publications for Aging

Articles related to Aging:

(show top 50) (show all 15929)
# Title Authors Year
1
Hydrocephalus in children under the age of five from diagnosis to short-/medium-/long-term progression: a retrospective review of 142 children. ( 29435827 )
2018
2
Rubella natural immunity among adolescent girls in Tanzania: the need to vaccinate child bearing aged women. ( 29298693 )
2018
3
HIV and syphilis epidemic among MSM and non-MSM aged 50 and above in Shanghai, China: A yearly cross-sectional study, 2008-2014. ( 29419357 )
2018
4
Aortic coarctation decision making comes of age. ( 29224838 )
2018
5
Prevalence, cause and diagnosis of lactose intolerance in children aged 1-5 years: a systematic review of 1995-2015 literature. ( 29222879 )
2018
6
Optimizing Pulmonary Embolism Computed Tomography in the Age of Individualized Medicine: A Prospective Clinical Study. ( 29438139 )
2018
7
Ageing impairs parasite-specific antibody responses in cystic echinococcosis. ( 29161459 )
2018
8
DNA methylation signatures reflect aging in patients with nonalcoholic steatohepatitis. ( 29367468 )
2018
9
Werner syndrome (WRN) gene variants and their association with altered function and age-associated diseases. ( 29146545 )
2018
10
Effect of chemical disinfectants and accelerated aging on maxillofacial silicone elastomers: An<i>In vitro</i>Study. ( 29442090 )
2018
11
Histologic chorioamnionitis in preterm infants: correlation with brain magnetic resonance imaging at term equivalent age. ( 29448926 )
2018
12
A Reassessment of Genes Modulating Aging in Mice Using Demographic Measurements of the Rate of Aging. ( 29444805 )
2018
13
Coping Mechanisms for Psychosomatic Symptoms among Aging Roman Catholic German priests. ( 29446050 )
2018
14
Effects of carvacrol on human fibroblast (WS-1) and gastric adenocarcinoma (AGS) cells in vitro and on Wistar rats in vivo. ( 29442269 )
2018
15
Mutations in L-type amino acid transporter-2 support<i>SLC7A8</i>as a novel gene involved in age-related hearing loss. ( 29355479 )
2018
16
The curvilinear relationship of early-life adversity and successful aging: the mediating role of mental health. ( 29447460 )
2018
17
Gastroesophageal Reflux Frequency, Severity, Age of Onset, Family History and Acid Suppressive Therapy Predict Barrett Esophagus in a Large Population. ( 29356784 )
2018
18
Chondrosarcoma: A Rare Misfortune in Aging Human Cartilage? The Role of Stem and Progenitor Cells in Proliferation, Malignant Degeneration and Therapeutic Resistance. ( 29361725 )
2018
19
Clinical Characteristics and Risk Factors for Poor Outcome in Infants Less Than 90 Days of Age with Bacterial Meningitis in the United Kingdom and Ireland. ( 29384979 )
2018
20
Association of Retinal Vascular Caliber and Age-Related Macular Degeneration in Patients With the Acquired Immunodeficiency Syndrome. ( 29435590 )
2018
21
Maternal obesity increases insulin resistance, low-grade inflammation and osteochondrosis lesions in foals and yearlings until 18 months of age. ( 29373573 )
2018
22
Differential vocational rehabilitation service patterns and outcomes for transition-age youth with autism. ( 29441662 )
2018
23
Efficacy and Safety of Nimotuzumab Plus Radiotherapy With or Without Cisplatin-Based Chemotherapy in an Elderly Patient Subgroup (Aged 60 and Older) With Nasopharyngeal Carcinoma. ( 29425953 )
2018
24
Overestimation of hyperopia with autorefraction compared with retinoscopy under cycloplegia in school-age children. ( 29439996 )
2018
25
<i>Porphyromonas gingivalis</i> , a periodontitis causing bacterium, induces memory impairment and age-dependent neuroinflammation in mice. ( 29422938 )
2018
26
Aging-like physiological changes in the skin of Japanese obese diabetic patients. ( 29449943 )
2018
27
Length of synostosis and segmented intracranial volume correlate with age in patients with non-syndromic sagittal synostosis. ( 29067505 )
2018
28
Inhibiting Cellular Senescence: A New Therapeutic Paradigm for Age-Related Osteoporosis. ( 29425296 )
2018
29
Effects of Aging on Transformation of Biogenic Magnetite Nanoparticles. ( 29448600 )
2018
30
Effects of Mg Addition with Natural Aging Time on Two-Step Aging Behavior in Al-Mg-Si Alloys. ( 29448743 )
2018
31
Long-term treadmill exercise improves memory impairment through restoration of decreased synaptic adhesion molecule 1/2/3 induced by transient cerebral ischemia in the aged gerbil hippocampus. ( 29341891 )
2018
32
Exposure to traffic-related air pollution and acute bronchitis in children: season and age as modifiers. ( 29440305 )
2018
33
Age of Infection with Kaposi Sarcoma Associated Herpesvirus and Subsequent Antibody Values Among Children in Uganda. ( 29369149 )
2018
34
Rolling and aging in temperature-ramp soft adhesion. ( 29448484 )
2018
35
Seropositivity of Hepatitis A in Children Aged 7-14 Years in Diyarbakir Province Center. ( 29445079 )
2018
36
Mice overexpressing lamin B1 in oligodendrocytes recapitulate the age-dependent motor signs, but not the early autonomic cardiovascular dysfunction of autosomal-dominant leukodystrophy (ADLD). ( 29262292 )
2018
37
Global Cerebral Atrophy Detected by Routine Imaging: Relationship with Age, Hippocampal Atrophy, and White Matter Hyperintensities. ( 29314393 )
2018
38
Exposure to cooking oil fumes and chronic bronchitis in nonsmoking women aged 40A years and over: a health-care based study. ( 29439699 )
2018
39
Lipoidal corneal degeneration in aged falcons. ( 29350449 )
2018
40
Socio-economic patterning in early mortality of patients aged 0-49 years diagnosed with primary bone cancer in Great Britain, 1985-2008. ( 29414632 )
2018
41
Cognitive control under stressful conditions in transitional age youth with bipolar disorder: Diagnostic and sleep-related differences in fronto-limbic activation patterns. ( 29441653 )
2018
42
Exploring current status of Helicobacter pylori infection in different age groups of patients with dyspepsia. ( 29368191 )
2018
43
The influence of gestational age, mode of delivery and abdominal wall closure method on the surgical outcome of neonates with uncomplicated gastroschisis. ( 29417204 )
2018
44
Does reduced mastication influence cognitive and systemic health during aging? ( 29452151 )
2018
45
Eating fish and farm life reduce allergic rhinitis at the age of twelve. ( 29446153 )
2018
46
Serum uric acid and prevalence of age-related hearing loss in the Japanese population: Baseline data from the Aidai Cohort Study in Yawatahama. ( 29339204 )
2018
47
Comprehensive knowledge on cervical cancer, attitude towards its screening and associated factors among women aged 30-49A years in Finote Selam town, northwest Ethiopia. ( 29444689 )
2018
48
Attention-deficit/hyperactivity disorder, joint hypermobility-related disorders and pain: expanding body-mind connections to the developmental age. ( 29446032 )
2018
49
Age-related changes in with-the-rule and oblique corneal astigmatism. ( 29369508 )
2018
50
Quercetin Suppresses CYR61-Mediated Multidrug Resistance in Human Gastric Adenocarcinoma AGS Cells. ( 29364834 )
2018

Variations for Aging

Expression for Aging

Search GEO for disease gene expression data for Aging.

Pathways for Aging

Pathways related to Aging according to GeneCards Suite gene sharing:

(show top 50) (show all 56)
# Super pathways Score Top Affiliating Genes
1
Show member pathways
13.05 AKT1 JUN PDGFRB PPARG TGFBR2 TP53
2
Show member pathways
12.89 AKT1 JUN LMNA PARP1 TP53
3
Show member pathways
12.79 AKT1 JUN LMNA PARP1 TP53 TP63
4 12.76 AKT1 JUN PDGFRB TGFBR2 TP53
5 12.72 AKT1 HIF1A JUN PDGFRB PPARG TGFBR2
6
Show member pathways
12.65 AKT1 JUN PDGFRB SIRT1 TP53
7
Show member pathways
12.53 AKT1 IL10 JUN SERPINE1 TGFBR2
8 12.52 AKT1 NAMPT PPARG SIRT1 SOD2
9
Show member pathways
12.41 AKT1 HIF1A JUN PDGFRB
10
Show member pathways
12.41 AKT1 JUN PDGFRB TGFBR2 TP53
11 12.39 AKT1 JUN PDGFRB TGFBR2 TP53
12
Show member pathways
12.33 SERPINE1 SOD1 SOD2 TP53
13 12.3 AKT1 IL10 JUN TP53
14
Show member pathways
12.27 AKT1 JUN LMNA PARP1
15
Show member pathways
12.25 AKT1 HIF1A SIRT1 TP53
16
Show member pathways
12.23 HIF1A NAMPT SERPINE1 SIRT1
17
Show member pathways
12.11 AKT1 JUN PPARG TGFBR2 TP53
18 12.1 AKT1 SERPINE1 SIRT1 TGFBR2 TP53
19 12.06 AKT1 JUN TGFBR2 TP53
20 12.06 AKT1 JUN SIRT1 TGFBR2 TP53
21 12.05 JUN SERPINE1 TP53 TP63
22
Show member pathways
12.04 AKT1 JUN PARP1 TP53
23 12.03 AKT1 JUN PPARG TGFBR2
24
Show member pathways
11.99 AKT1 HIF1A JUN PPARG SERPINE1 TP53
25 11.97 AKT1 JUN SOD2 TP53
26 11.96 AKT1 HIF1A IL10 TP53
28
Show member pathways
11.91 AKT1 IL10 SIRT1 SOD2 TGFBR2
29 11.87 AKT1 JUN SERPINE1 TGFBR2
30 11.85 AKT1 JUN PPARG TGFBR2
31 11.84 HIF1A LMNA NAMPT PPARG SERPINE1
32 11.83 AKT1 TP53 TP63
33
Show member pathways
11.81 AKT1 JUN PDGFRB
34 11.8 AKT1 JUN TP53
35 11.78 JUN SIRT1 TP53
36 11.75 AKT1 IL10 JUN SERPINE1
37 11.74 AKT1 PPARG SIRT1
38 11.7 AKT1 JUN SOD1
39 11.69 AKT1 JUN WRN
40
Show member pathways
11.68 AKT1 KL PPARG SIRT1 SOD1 SOD2
41 11.67 HIF1A JUN TP53
42 11.67 AKT1 HIF1A JUN SOD1
43 11.65 AKT1 HIF1A PDGFRB TP53
44 11.64 AKT1 HIF1A JUN SERPINE1
45 11.62 JUN SERPINE1 TGFBR2
46 11.6 JUN PPARG SIRT1
47 11.58 HIF1A JUN TP53
48 11.57 AKT1 HIF1A PDGFRB
49
Show member pathways
11.57 AKT1 JUN TP53
50 11.51 AKT1 SIRT1 SOD2

GO Terms for Aging

Cellular components related to Aging according to GeneCards Suite gene sharing:

# Name GO ID Score Top Affiliating Genes
1 nuclear chromatin GO:0000790 9.62 JUN SIRT1 TP53 TP63
2 protein complex GO:0043234 9.5 AKT1 HIF1A PARP1 PPARG SOD1 TP53
3 transcription factor complex GO:0005667 9.02 HIF1A JUN PARP1 TP53 TP63
4 cytosol GO:0005829 10.18 AKT1 HIF1A JUN LMNA NAMPT PPARG
5 nucleus GO:0005634 10.03 AKT1 HIF1A JUN LMNA NAMPT PARP1
6 mitochondrion GO:0005739 10.01 AKT1 PARP1 SIRT1 SNCA SOD1 SOD2
7 nucleoplasm GO:0005654 10 AKT1 HIF1A JUN LMNA PARP1 PPARG

Biological processes related to Aging according to GeneCards Suite gene sharing:

(show top 50) (show all 69)
# Name GO ID Score Top Affiliating Genes
1 positive regulation of angiogenesis GO:0045766 9.97 HIF1A SERPINE1 SIRT1 TGFBR2
2 regulation of signal transduction by p53 class mediator GO:1901796 9.97 AKT1 TP53 TP63 WRN
3 rhythmic process GO:0048511 9.96 NAMPT PPARG SIRT1 TP53
4 negative regulation of neuron apoptotic process GO:0043524 9.96 HIF1A JUN SNCA SOD1 SOD2
5 cellular response to hypoxia GO:0071456 9.93 AKT1 HIF1A LMNA SIRT1 TP53
6 response to oxidative stress GO:0006979 9.93 AKT1 SIRT1 SOD1 SOD2 TP53 WRN
7 transforming growth factor beta receptor signaling pathway GO:0007179 9.92 JUN PARP1 SIRT1 TGFBR2
8 liver development GO:0001889 9.91 JUN RGN SOD2
9 cellular response to insulin stimulus GO:0032869 9.91 AKT1 PARP1 PPARG
10 insulin receptor signaling pathway GO:0008286 9.91 AKT1 KL NAMPT
11 cellular response to oxidative stress GO:0034599 9.91 PARP1 SNCA SOD1 SOD2
12 positive regulation of endothelial cell proliferation GO:0001938 9.91 AKT1 HIF1A IL10 JUN SIRT1
13 response to organic cyclic compound GO:0014070 9.91 JUN NAMPT PDGFRB PPARG TGFBR2 TP53
14 protein homotetramerization GO:0051289 9.9 SOD2 TP53 TP63
15 regulation of blood pressure GO:0008217 9.89 PPARG SOD1 SOD2
16 circadian rhythm GO:0007623 9.89 JUN NAMPT SERPINE1 SIRT1
17 positive regulation of smooth muscle cell proliferation GO:0048661 9.89 AKT1 JUN NAMPT PDGFRB TGFBR2
18 response to mechanical stimulus GO:0009612 9.88 JUN PPARG TGFBR2
19 response to estrogen GO:0043627 9.88 PDGFRB PPARG TGFBR2
20 response to hydrogen peroxide GO:0042542 9.88 JUN PDGFRB SIRT1 SOD1 SOD2
21 interleukin-12-mediated signaling pathway GO:0035722 9.87 IL10 SOD1 SOD2
22 negative regulation of neuron death GO:1901215 9.86 AKT1 SIRT1 SNCA
23 outflow tract morphogenesis GO:0003151 9.86 HIF1A JUN TGFBR2
24 response to drug GO:0042493 9.86 IL10 JUN PPARG SNCA SOD1 SOD2
25 response to retinoic acid GO:0032526 9.85 PDGFRB PPARG TP53
26 positive regulation of epithelial cell migration GO:0010634 9.84 HIF1A JUN TGFBR2
27 positive regulation of blood vessel endothelial cell migration GO:0043536 9.83 AKT1 HIF1A SIRT1
28 response to gamma radiation GO:0010332 9.83 PARP1 SOD2 TP53 TP63
29 cellular response to reactive oxygen species GO:0034614 9.82 AKT1 JUN TP53
30 cellular response to cadmium ion GO:0071276 9.81 AKT1 JUN SOD1
31 positive regulation of reactive oxygen species metabolic process GO:2000379 9.8 PDGFRB TGFBR2 TP53
32 intrinsic apoptotic signaling pathway in response to DNA damage by p53 class mediator GO:0042771 9.8 SIRT1 TP53 TP63
33 response to organic substance GO:0010033 9.8 AKT1 IL10 JUN PPARG SOD1 TGFBR2
34 positive regulation of pri-miRNA transcription by RNA polymerase II GO:1902895 9.78 HIF1A JUN TP53
35 response to hyperoxia GO:0055093 9.76 PDGFRB SOD2 TP53
36 white fat cell differentiation GO:0050872 9.74 PPARG SIRT1
37 negative regulation of DNA biosynthetic process GO:2000279 9.74 RGN TP53
38 replicative senescence GO:0090399 9.74 SERPINE1 TP53
39 negative regulation of oxidative stress-induced intrinsic apoptotic signaling pathway GO:1902176 9.74 AKT1 SIRT1 SOD2
40 response to caffeine GO:0031000 9.73 PPARG TP53
41 negative regulation of apoptotic process GO:0043066 9.73 AKT1 HIF1A IL10 JUN PDGFRB RGN
42 hydrogen peroxide biosynthetic process GO:0050665 9.72 SOD1 SOD2
43 negative regulation of telomerase activity GO:0051974 9.72 PPARG TP53
44 mitotic G1 DNA damage checkpoint GO:0031571 9.72 TP53 TP63
45 retina vasculature development in camera-type eye GO:0061298 9.72 HIF1A PDGFRB
46 response to fluid shear stress GO:0034405 9.71 AKT1 PDGFRB
47 positive regulation of glucose metabolic process GO:0010907 9.71 AKT1 RGN
48 response to superoxide GO:0000303 9.7 SOD1 SOD2
49 oxygen homeostasis GO:0032364 9.7 HIF1A SOD2
50 peripheral nervous system myelin maintenance GO:0032287 9.7 AKT1 SOD1

Molecular functions related to Aging according to GeneCards Suite gene sharing:

(show all 14)
# Name GO ID Score Top Affiliating Genes
1 protein kinase binding GO:0019901 9.89 AKT1 HIF1A PARP1 PDGFRB TP53
2 chromatin binding GO:0003682 9.88 JUN PPARG TP53 TP63 WRN
3 transcription regulatory region DNA binding GO:0044212 9.72 JUN PPARG SNCA TP53 TP63
4 identical protein binding GO:0042802 9.7 AKT1 JUN NAMPT PARP1 PPARG SIRT1
5 transcription factor binding GO:0008134 9.63 HIF1A JUN PARP1 PPARG SIRT1 TP53
6 copper ion binding GO:0005507 9.61 SNCA SOD1 TP53
7 p53 binding GO:0002039 9.56 HIF1A SIRT1 TP53 TP63
8 core promoter sequence-specific DNA binding GO:0001046 9.54 PPARG SIRT1 TP53
9 MDM2/MDM4 family protein binding GO:0097371 9.46 TP53 TP63
10 superoxide dismutase activity GO:0004784 9.4 SOD1 SOD2
11 enzyme binding GO:0019899 9.36 AKT1 HIF1A JUN PARP1 PDGFRB PPARG
12 protein binding GO:0005515 10.44 AKT1 HIF1A IL10 JUN LMNA NAMPT
13 metal ion binding GO:0046872 10.28 PARP1 PPARG RGN SIRT1 SNCA SOD1
14 zinc ion binding GO:0008270 10 PARP1 PPARG RGN SNCA SOD1 TP53

Sources for Aging

3 CDC
7 CNVD
9 Cosmic
10 dbSNP
11 DGIdb
16 ExPASy
18 FMA
27 GO
28 GTR
29 HGMD
30 HMDB
31 HPO
32 ICD10
33 ICD10 via Orphanet
34 ICD9CM
35 IUPHAR
36 KEGG
37 LifeMap
39 MedGen
41 MeSH
42 MESH via Orphanet
43 MGI
45 NCI
46 NCIt
47 NDF-RT
50 NINDS
51 Novoseek
53 OMIM
54 OMIM via Orphanet
58 PubMed
60 QIAGEN
65 SNOMED-CT via HPO
66 SNOMED-CT via Orphanet
67 TGDB
68 Tocris
69 UMLS
70 UMLS via Orphanet