MCID: AGN002
MIFTS: 46

Agnosia malady

Rare diseases, Fetal diseases, Eye diseases categories

Summaries for Agnosia

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Sources:
9Disease Ontology, 44NIH Rare Diseases, 45NINDS, 66Wikipedia, 34MalaCards
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NINDS:45 Agnosia is a rare disorder characterized by an inability to recognize and identify objects or persons. People with agnosia may have difficulty recognizing the geometric features of an object or face or may be able to perceive the geometric features but not know what the object is used for or whether a face is familiar or not. Agnosia can be limited to one sensory modality such as vision or hearing. For example, a person may have difficulty in recognizing an object as a cup or identifying a sound as a cough. Agnosia can result from strokes, dementia, developmental disorders, or other neurological conditions. It typically results from damage to specific brain areas in the occipital or parietal lobes of the brain. People with agnosia may retain their cognitive abilities in other areas.

MalaCards: Agnosia, also known as dyspraxia, is related to associative agnosia and pain agnosia. An important gene associated with Agnosia is BBS2 (Bardet-Biedl syndrome 2), and among its related pathways are Signaling by NOTCH1 PEST Domain Mutants in Cancer and Wnt / Hedgehog / Notch. Affiliated tissues include brain, parietal lobe and eye, and related mouse phenotypes are taste/olfaction and hearing/vestibular/ear.

Disease Ontology:9 A communication disorder that is a loss of ability to recognize objects, persons, sounds, shapes, or smells while the specific sense is not defective nor is there any significant memory loss.

NIH Rare Diseases:44 Agnosia is characterized by an inability to recognize and identify objects and/or persons. symptoms may vary, according to the area of the brain that is affected.Ā it can be limited to one sensory modality such as vision or hearing; for example, a person may have difficulty in recognizing an object as a cup or identifying a sound as a cough. agnosia can result from strokes, traumatic brain injury, dementia, a tumor, developmental disorders, overexposure to environmental toxins (e.g., carbon monoxide poisoning), or other neurological conditions. visual agnosia may also occur in association with other underlying disorders. people with agnosia may retain their cognitive abilities in other areas. treatment of primary agnosia is symptomatic and supportive; when it is caused by an underlying disorder, treatment of the disorderĀ may reduce symptoms and help prevent further brain damage. last updated: 4/22/2011

Wikipedia:66 Agnosia is a loss of ability to recognize objects, persons, sounds, shapes, or smells while the specific... more...

Aliases & Classifications for Agnosia

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9Disease Ontology, 44NIH Rare Diseases, 45NINDS, 63UMLS, 59SNOMED-CT, 41NCIt, 36MeSH, 26ICD10
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Classifications:

Malacards categories (disease lists): (See all malacards categories)
Global: Rare diseases, Fetal diseases
Anatomical: Eye diseases


Aliases & Descriptions:

agnosia 9 44 45 63
dyspraxia 9 45
monomodal visual amnesia 44
primary visual agnosia 44
dyspraxia syndrome 9
visual amnesia 44


Related Diseases for Agnosia

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Sources:
18GeneCards, 19GeneDecks
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Graphical network of the top 20 diseases related to Agnosia:



Diseases related to agnosia

Symptoms for Agnosia

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Drugs & Therapeutics for Agnosia

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Sources:
6CenterWatch, 43NIH Clinical Center, 7ClinicalTrials
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Approved drugs:

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Drug clinical trials:

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Genetic Tests for Agnosia

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Anatomical Context for Agnosia

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34MalaCards
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MalaCards organs/tissues related to Agnosia:

34
Brain, Parietal lobe, Eye, Temporal lobe, Cortex, Testes, T cells

Animal Models for Agnosia or affiliated genes

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38MGI
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MGI Mouse Phenotypes related to Agnosia:

38
idDescriptionMGI Source AccessionScoreTop Affiliating Genes
1MP:00053949.6TRPA1, BBS2
2MP:00053778.3TRPA1, OPRL1, JAG2
3MP:00107718.2TRPA1, OPRL1, BBS2, JAG2

Publications for Agnosia

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53PubMed
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Articles related to Agnosia:

(show top 50)    (show all 368)
idTitleAuthorsYear
1
Corticobasal syndrome presenting with partial Gerstmann's syndrome and digit agnosia. (23686076)
2013
2
Impaired integration of emotional faces and affective body context in a rare case of developmental visual agnosia. (21482423)
2012
3
Eye movements during object recognition in visual agnosia. (22627025)
2012
4
Modeling eye movements in visual agnosia with a saliency map approach: bottom-up guidance or top-down strategy? (21316191)
2011
5
The functional neuroanatomy of object agnosia: a case study. (21745637)
2011
6
A case of complex regional pain syndrome with agnosia for object orientation. (21450404)
2011
7
Associative visual agnosia: a case study. (18413915)
2008
8
Specular right-left disorientation, finger-agnosia, and asomatognosia in right hemisphere stroke. (17846515)
2007
9
Preserved implicit form perception and orientation adaptation in visual form agnosia. (16620887)
2006
10
Covert colour processing in colour agnosia. (16420956)
2006
11
No double-dissociation between optic ataxia and visual agnosia: multiple sub-streams for multiple visuo-manual integrations. (16753188)
2006
12
Agnosia for object orientation: naming and mental rotation evidence. (12221142)
2002
13
Hierarchical versus parallel processing in tactile object recognition: a behavioural-neuroanatomical study of aperceptive tactile agnosia. (12390978)
2002
14
The role of premorbid expertise on object identification in a patient with category-specific visual agnosia. (20957546)
2002
15
Animals and artifacts may not be treated equally: differentiating strong and weak forms of category-specific visual agnosia. (11237370)
2001
16
Visual agnosia after treatment of a posterior fossa ependymoma in a 16-month-old girl. (11575616)
2001
17
The influence of premorbid language skills and behavior on language recovery in children with verbal auditory agnosia. (10641609)
2000
18
Superior single dimension relative to "exclusive or" categorization performance by a patient with category-specific visual agnosia: empirical data and an ALCOVE simulation. (10857684)
2000
19
Perception of dynamic acoustic patterns by an individual with unilateral verbal auditory agnosia. (10860565)
2000
20
Impaired face and word recognition without object agnosia. (9920470)
1999
21
The perception of spatial relations in a patient with visual form agnosia. (22448842)
1998
22
Grasping spatial relationships: failure to demonstrate allocentric visual coding in a patient with visual form agnosia. (9787053)
1998
23
Separate visual pathways for perception of actions and objects: evidence from a case of apperceptive agnosia. (9728957)
1998
24
Optic aphasia with pure alexia: a mild form of visual associative agnosia? A case study. (9669108)
1998
25
Agnosia for object orientation: implications for theories of object recognition. (9025119)
1997
26
Visual agnosia with bilateral temporo-occipital brain lesions in a child with autistic disorder: a case study. (9352734)
1997
27
Finger agnosia: fiction or reality? (8179491)
1994
28
Visual agnosia: a case of reduced attentional "spotlight"? (1478087)
1992
29
The role of sensorimotor experience in object recognition. A case of multimodal agnosia. (1782531)
1991
30
Auditory agnosia with relative sparing of speech perception. (2707006)
1989
31
Loss of topographic familiarity. An environmental agnosia. (3947250)
1986
32
Visual agnosia without alexia. (6539870)
1984
33
Developmental auditory agnosia in the severely retarded: a further investigation. (7427711)
1980
34
Prosopagnosia and visual object agnosia: a behavioral study. (656903)
1978
35
Distinctive features of unilateral spatial agnosia in right and left brain-damaged patients. (615703)
1977
36
Generalized auditory agnosia: the first phase of treatment. (5027354)
1972
37
Visual agnosia. (4577659)
1972
38
Visual agnosia. (4671311)
1972
39
A case study of auditory agnosia: linguistic and non-linguistic processing. (4671674)
1972
40
Right-sided unilateral visual spatial agnosia, asomatognosia and anosognosia with left hemisphere lesions. (5806126)
1969
41
The child who does not talk. Problems of diagnosis with special reference to children with severe auditory agnosia. (5999081)
1966
42
PURE AUDITORY AGNOSIA ASSOCIATED WITH ALTERATION OF VOICE AND PERSONAL CHARACTER. A CASE REPORT. (14332144)
1965
43
OBSERVATIONS ON COLOUR AGNOSIA. (14200783)
1964
44
Clumsy children: developmental apraxia and agnosia. (13998739)
1962
45
Sensory deprivation, sensory suppression and agnosia: notes for a neurologic theory. (13776128)
1961
46
Agnosia in animal and man. (13056106)
1953
47
Visual agnosia and alternating dominance; analysis of a case. (13109456)
1953
48
Visual agnosia for animate objects. (13085184)
1953
49
Cerebral localization in aphasia and agnosia. (14770629)
1950
50
Aphasia, apraxia, and agnosia; a new classification. (21017997)
1946

Variations for Agnosia

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Expression for genes affiliated with Agnosia

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2BioGPS, 16Gene Expression Omnibus DataSets
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Expression patterns in normal tissues for genes affiliated with Agnosia

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Pathways for genes affiliated with Agnosia

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Sources:
51PathCards, 56Reactome, 5Cell Signaling Technology, 31KEGG, 39NCBI BioSystems Database, 54QIAGEN, 61Thomson Reuters, 55R&D Systems
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Pathways related to Agnosia according to GeneCards/GeneDecks:

idSuper pathways (with members indented)ScoreTop Affiliating Genes
1
Show member pathways
9.2PSENEN, JAG2
29.2PSENEN, JAG2
3
Show member pathways
Delta-Notch Signaling Pathway39
Notch Signaling Pathway39
9.2JAG2, PSENEN
4
Show member pathways
Development Notch Signaling Pathway61
Transcription Sin3 and NuRD in transcription regulation61
9.2PSENEN, JAG2
5
Show member pathways
Notch signaling pathway39
9.2PSENEN, JAG2
69.2PSENEN, JAG2
7
Show member pathways
9.2PSENEN, JAG2
8
Show member pathways
8.3TAGAP, OPRL1, PSENEN, JAG2

Compounds for genes affiliated with Agnosia

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GO Terms for genes affiliated with Agnosia

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17Gene Ontology
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Cellular components related to Agnosia according to GeneCards/GeneDecks:

idNameGO IDScoreTop Affiliating Genes
1integral component of plasma membraneGO:0058878.2TRPA1, OPRL1, PSENEN, JAG2

Biological processes related to Agnosia according to GeneCards/GeneDecks:

idNameGO IDScoreTop Affiliating Genes
1Notch signaling pathwayGO:0072199.2PSENEN, JAG2
2Notch receptor processingGO:0072208.9PSENEN, JAG2

Products for genes affiliated with Agnosia

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Sources for Agnosia

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4CDC
14ExPASy
15FMA
23GTR
24HGMD
25HMDB
26ICD10
27ICD10 via Orphanet
28ICD9CM
30IUPHAR
31KEGG
36MeSH
37MESH via Orphanet
38MGI
41NCIt
42NDF-RT
45NINDS
46Novoseek
48OMIM
49OMIM via Orphanet
53PubMed
54QIAGEN
60SNOMED-CT via Orphanet
63UMLS
64UMLS via Orphanet