MCID: AGN002
MIFTS: 56

Agnosia malady

Categories: Rare diseases, Mental diseases, Eye diseases

Aliases & Classifications for Agnosia

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Aliases & Descriptions for Agnosia:

Name: Agnosia 11 47 48 26 38 13 67
Primary Visual Agnosia 47 67
Dyspraxia 11 48
Apraxias 38 67
 
Monomodal Visual Amnesia 47
Dyspraxia Syndrome 11
Visual Amnesia 47
Alexia 67

Classifications:



Summaries for Agnosia

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NINDS:48 Agnosia is a rare disorder characterized by an inability to recognize and identify objects or persons. People with agnosia may have difficulty recognizing the geometric features of an object or face or may be able to perceive the geometric features but not know what the object is used for or whether a face is familiar or not. Agnosia can be limited to one sensory modality such as vision or hearing. For example, a person may have difficulty in recognizing an object as a cup or identifying a sound as a cough. Agnosia can result from strokes, dementia, developmental disorders, or other neurological conditions. It typically results from damage to specific brain areas in the occipital or parietal lobes of the brain. People with agnosia may retain their cognitive abilities in other areas.

MalaCards based summary: Agnosia, also known as primary visual agnosia, is related to semantic agnosia and visual agnosia, and has symptoms including hemiasomatognosia, altered pitch perception and autoscopy. An important gene associated with Agnosia is OPRM1 (Opioid Receptor Mu 1), and among its related pathways are Syndecan-3-mediated signaling events and Peptide ligand-binding receptors. Affiliated tissues include brain, parietal lobe and temporal lobe, and related mouse phenotypes are adipose tissue and behavior/neurological.

Disease Ontology:11 A communication disorder that is a loss of ability to recognize objects, persons, sounds, shapes, or smells while the specific sense is not defective nor is there any significant memory loss.

Wikipedia:70 Agnosia is the inability to process sensory information. Often there is a loss of ability to recognize... more...

Related Diseases for Agnosia

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Diseases in the Agnosia family:

Form Agnosia

Diseases related to Agnosia via text searches within MalaCards or GeneCards Suite gene sharing:

(show top 50)    (show all 96)
idRelated DiseaseScoreTop Affiliating Genes
1semantic agnosia28.2AP1M2, AP2M1, CCK, CNR1, HTR7, LIPN
2visual agnosia12.2
3auditory agnosia12.2
4apperceptive agnosia12.2
5rolandic epilepsy, mental retardation, and speech dyspraxia12.2
6verbal auditory agnosia12.1
7finger agnosia12.1
8developmental dyspraxia12.1
9integrative agnosia12.1
10tactile agnosia12.1
11form agnosia12.1
12topographical agnosia12.1
13social emotional agnosia12.1
14associative agnosia12.1
15pain agnosia12.0
16mirror agnosia12.0
17visual verbal agnosia12.0
18time agnosia11.9
19color agnosia11.9
20rolandic epilepsy-speech dyspraxia syndrome11.8
21astereognosia11.4
22autotopagnosia11.3
23cortical deafness11.2
24prosopagnosia11.2
25gerstmann syndrome11.1
26apraxia11.1
27alexia11.1
28alexithymia11.0
29amusia11.0
30anosognosia11.0
31agraphia11.0
32phonagnosia11.0
33achromatopsia11.0
34simultanagnosia11.0
35akinetopsia10.6
36kluver-bucy syndrome10.6
37nominal aphasia10.6
38hyperlipidemia type 310.6
39lymphocytic hypophysitis10.5CNR1, TRPV1
40morphine dependence10.5OPRM1, PDYN, POMC
41pediatric mesenchymal chondrosarcoma10.5PDYN, POMC
42malt worker's lung10.5CCK, TAC1
43focal hand dystonia10.5OXT, TAC1
44transient global amnesia10.5PDYN, PSENEN
45corneal dystrophy10.4CCK, OPRK1, OPRM1
46vulvar melanoma10.4CCK, OPRM1, TAC1
47lymphosarcoma10.4CCK, CNR1, POMC
48ureter adenocarcinoma10.4CCK, PDYN
49congenital epulis10.4LIPN, OXT, POMC
50hypertropia10.4OPRK1, OPRM1, PNOC

Graphical network of the top 20 diseases related to Agnosia:



Diseases related to agnosia

Symptoms for Agnosia

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UMLS symptoms related to Agnosia:


hemiasomatognosia, altered pitch perception, autoscopy, gait dyspraxia, symptoms, amimia, hemiapraxia, cortical dysfunction nec, neurologic neglect syndrome, hot flushes, neurobehavioral manifestations, dyspraxia of arm, abnormal coordination, specific learning problem, neurological symptom/complaint other, dyslexia and other symbolic dysfunctions, not elsewhere classified, other and unspecified symbolic dysfunctions, other and unspecified lack of coordination, visual agnosia, disturbance of consciousness, extrapyramidal sign, clumsiness, vertigo, torticollis, syncope, signs and symptoms, digestive, signs and symptoms, seizures, muscle rigidity, lethargy, headache, enuresis, dyspnea, cyanosis, cachexia, alexia and agraphia present, scanning speech, hallucinations, olfactory

Drugs & Therapeutics for Agnosia

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Drugs for Agnosia (from DrugBank, HMDB, Dgidb, PharmGKB, IUPHAR, NovoSeek, BitterDB):

idNameStatusPhaseClinical TrialsCas NumberPubChem Id
1
Oxytocinapproved, vet_approvedEarly Phase 140850-56-6439302, 53477758
Synonyms:
(2S)-1-[(4R,7S,10S,13S,16S,19R)-19-amino-7-(2-amino-2-oxoethyl)-10-(3-amino-3-oxopropyl)-13-[(2S)-butan-2-yl]-16-[(4-hydroxyphenyl)methyl]-6,9,12,15,18-pentaoxo-1,2-dithia-5,8,11,14,17-pentazacycloicosane-4-carbonyl]-N-[(2S)-1-[(2-amino-2-oxoethyl)amino]-4-methyl-1-oxopentan-2-yl]pyrrolidine-2-carboxamide
(Arg8)-Vasopressin
(Arg8)-Vasotocin
1-({(4R,7S,10S,13S,16S,19R)-19-amino-7-(2-amino-2-oxoethyl)-10-(3-amino-3-oxopropyl)-16-(4-hydroxybenzyl)-13-[(1S)-1-methylpropyl]-6,9,12,15,18-pentaoxo-1,2-dithia-5,8,11,14,17-pentaazacycloicosan-4-yl}carbonyl)-L-prolyl-L-leucylglycinamide
50-56-6
AC1L9735
Argipressin
Argpressin Acetate
BCBcMAP01_000094
Biotinyl-(Arg8)-Vasopressin
C00746
CHEBI:492195
CHEBI:7872
CHEMBL395429
CID439302
Cys-Tyr-Ile-Gln-Asn-Cys-Pro-Arg-Gly-NH2
Cys-Tyr-Ile-Gln-Asn-Cys-Pro-Leu-Gly-NH2
Cys-Tyr-Ile-Thr-Asn-Cys-Gly-Leu-Gly-NH2
Cys-Tyr-Phe-Gln-Asn-Cys-Pro-Arg-Gly-NH2
Cys-Tyr-Phe-Gln-Asn-Cys-Pro-Lys-Gly-NH2
D00089
Disulfide bridge Cys1-Cys6
Gly-Leu-Pro-c
HS-2021
 
L-Cysteinyl-L-tyrosyl-L-isoleucyl-L-glutaminyl-L-asparaginyl-L-cysteinyl-L-prolyl-L-leucylglycinamide cyclic(1-6)-disulfide
MolPort-003-938-941
NCGC00167132-01
O3251_SIGMA
O4375_SIGMA
OXT
OXYTOCIN
Ocytocin
Oxitocina
Oxytocic hormone
Oxytocin (JP15/USP/INN)
Oxytocin (TN)
Oxytocin 10 Usp Units In Dextrose 5%
Oxytocin 20 Usp Units In Dextrose 5%
Oxytocin 5 Usp Units In Dextrose 5%
Oxytocin Acetate
Oxytocin injection
Oxytocine
Oxytocinum
Pitocin
Pitocin (TN)
Syntocinon
Syntocinon (TN)
TI-001
alpha-Hypophamine
nchembio.184-comp2
2OxytocicsEarly Phase 1660

Interventional clinical trials:

idNameStatusNCT IDPhase
1Perception and Multisensory Integration in Neurological Patients Using fMRIUnknown statusNCT01469858
2Orientation Agnosia: Clinical and Anatomical StudyCompletedNCT01304576
3Functional Magnetic Resonance Imaging (fMRI) of Anosognosia in Amnestic Mild Cognitive Impairment (MCI) and Alzheimer's Disease (AD)CompletedNCT00908999
4Lack of Awareness of Symptoms (Anosognosia) in PD: An Observational Study for People With Parkinson'sRecruitingNCT02561715
5Anosognosia Evaluation After Cranocerebral Trauma Moderate to SevereRecruitingNCT02333006
6Processing Integration in Neurological Patients Using fMRINot yet recruitingNCT02722070
7The Effect of Oxytocin on Face PerceptionSuspendedNCT02091817Early Phase 1

Search NIH Clinical Center for Agnosia


Cochrane evidence based reviews: apraxias

Genetic Tests for Agnosia

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Genetic tests related to Agnosia:

id Genetic test Affiliating Genes
1 Agnosia26

Anatomical Context for Agnosia

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MalaCards organs/tissues related to Agnosia:

35
Brain, Parietal lobe, Temporal lobe, Cortex, Eye, Testes, T cells

Animal Models for Agnosia or affiliated genes

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MGI Mouse Phenotypes related to Agnosia:

40
idDescriptionMGI Source AccessionScoreTop Affiliating Genes
1MP:000537510.1CNR1, OPRM1, OXT, PDYN, POMC, TRPV1
2MP:00053868.8CCK, CNR1, HTR7, OPRK1, OPRL1, OPRM1
3MP:00107718.3CNR1, HTR7, OPRK1, OPRL1, OPRM1, OXT

Publications for Agnosia

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Articles related to Agnosia:

(show top 50)    (show all 407)
idTitleAuthorsYear
1
Agnosia for head tremor in essential tremor: prevalence and clinical correlates. (26877883)
2016
2
Affective agnosia: Expansion of the alexithymia construct and a new opportunity to integrate and extend Freud's legacy. (26054794)
2015
3
Simultanagnosia and scene agnosia induced by right posterior cerebral artery infarction: a case report. (26369377)
2015
4
Functional Mapping of the Human Auditory Cortex: fMRI Investigation of a Patient with Auditory Agnosia from Trauma to the Inferior Colliculus. (26413744)
2015
5
Reprint of: Visual processing of words in a patient with visual form agnosia: A behavioural and fMRI study. (26475097)
2015
6
Corticobasal syndrome presenting with partial Gerstmann's syndrome and digit agnosia. (23686076)
2013
7
Eye movements during object recognition in visual agnosia. (22627025)
2012
8
Development of a vocabulary of object shapes in a child with a very-early-acquired visual agnosia: a unique case. (20680887)
2011
9
Preserved implicit form perception and orientation adaptation in visual form agnosia. (16620887)
2006
10
Covert colour processing in colour agnosia. (16420956)
2006
11
A 3-year follow-up study of 'orientation agnosia'. (15817180)
2005
12
A Case Study of Visual Agnosia without Perceptual Processing or Structural Descriptions Impairment. (20957586)
2003
13
The role of premorbid expertise on object identification in a patient with category-specific visual agnosia. (20957546)
2002
14
Superior single dimension relative to "exclusive or" categorization performance by a patient with category-specific visual agnosia: empirical data and an ALCOVE simulation. (10857684)
2000
15
Perception of dynamic acoustic patterns by an individual with unilateral verbal auditory agnosia. (10860565)
2000
16
Number processing and calculation in a case of visual agnosia. (10921666)
2000
17
Auditory agnosia restricted to environmental sounds following cortical deafness and generalized auditory agnosia. (10996714)
2000
18
Impaired face and word recognition without object agnosia. (9920470)
1999
19
Grasping spatial relationships: failure to demonstrate allocentric visual coding in a patient with visual form agnosia. (9787053)
1998
20
Separate visual pathways for perception of actions and objects: evidence from a case of apperceptive agnosia. (9728957)
1998
21
Chronic auditory agnosia following Landau-Kleffner syndrome: a 23 year outcome study. (9672766)
1998
22
Agnosia for object orientation: implications for theories of object recognition. (9025119)
1997
23
Literature update. Agnosia in Alzheimer disease. (9305505)
1997
24
Visual form agnosia in multiple sclerosis. (8874592)
1996
25
A comment on apperceptive agnosia. (7546671)
1995
26
Capgras syndrome: agnosia of identification and delusion of reduplication. (7846236)
1994
27
Visual agnosia: a case of reduced attentional "spotlight"? (1478087)
1992
28
Selective loss of imagery in a case of visual agnosia. (1528412)
1992
29
The role of sensorimotor experience in object recognition. A case of multimodal agnosia. (1782531)
1991
30
A case of integrative visual agnosia. (3427396)
1987
31
Loss of topographic familiarity. An environmental agnosia. (3947250)
1986
32
Correlation between EEG and auditory perceptual measures in auditory agnosia. (6722527)
1984
33
Taste agnosia following gustatory neocortex ablation: dissociation from odor and generality across taste qualities. (6540588)
1984
34
Auditory agnosia. (6125975)
1982
35
Distinctive features of unilateral spatial agnosia in right and left brain-damaged patients. (615703)
1977
36
A visual-speech disconnexion syndrome. Report of a case with optic aphasia, agnosic alexia and colour agnosia. (4773861)
1973
37
Generalized auditory agnosia: the first phase of treatment. (5027354)
1972
38
Right-sided unilateral visual spatial agnosia, asomatognosia and anosognosia with left hemisphere lesions. (5806126)
1969
39
PURE AUDITORY AGNOSIA ASSOCIATED WITH ALTERATION OF VOICE AND PERSONAL CHARACTER. A CASE REPORT. (14332144)
1965
40
OBSERVATIONS ON COLOUR AGNOSIA. (14200783)
1964
41
Clumsy children: developmental apraxia and agnosia. (13998739)
1962
42
Agnosia for faces (prosopagnosia). (13905818)
1962
43
An analysis of agnosia. (13165875)
1954
44
Visual agnosia and alternating dominance; analysis of a case. (13109456)
1953
45
Visual agnosia for animate objects. (13085184)
1953
46
Cerebral localization in aphasia and agnosia. (14770629)
1950
47
Visual-spatial agnosia associated with lesions of the right cerebral hemisphere. (14791786)
1950
48
Pure visual verbal agnosia with spatial disorientation; report of a case. (18910047)
1948
49
Unilateral auditory-spatial agnosia. (18879812)
1948
50
Aphasia, apraxia, and agnosia; a new classification. (21017997)
1946

Variations for Agnosia

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Expression for genes affiliated with Agnosia

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Search GEO for disease gene expression data for Agnosia.

Pathways for genes affiliated with Agnosia

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GO Terms for genes affiliated with Agnosia

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Cellular components related to Agnosia according to GeneCards Suite gene sharing:

idNameGO IDScoreTop Affiliating Genes
1postsynapseGO:009879410.4NPFF, OPRM1
2neuron projectionGO:004300510.0OPRK1, OPRL1, OPRM1, TRPV1
3terminal boutonGO:00431959.9AP2M1, CCK, OXT
4perikaryonGO:00432049.7CCK, NPFF, OPRK1, OPRM1
5neuronal cell bodyGO:00430259.5CCK, OPRK1, PDYN, PNOC, TAC1, TRPV1
6axon terminusGO:00436799.5NPFF, OPRK1, PDYN, PNOC
7dendriteGO:00304259.1CCK, NPFF, OPRK1, OPRM1, PDYN, PNOC
8integral component of plasma membraneGO:00058879.1CNR1, HTR7, OPRK1, OPRL1, OPRM1, PSENEN
9extracellular regionGO:00055769.0CCK, LIPN, NPFF, OXT, PDYN, PNOC
10plasma membraneGO:00058867.4AP2M1, CNR1, HTR7, OPRK1, OPRL1, OPRM1

Biological processes related to Agnosia according to GeneCards Suite gene sharing:

(show all 28)
idNameGO IDScoreTop Affiliating Genes
1adenylate cyclase-inhibiting opioid receptor signaling pathwayGO:003163510.7OPRK1, OPRM1
2positive regulation of gastric acid secretionGO:006045410.7OPRL1, TRPV1
3negative regulation of heart rateGO:001045910.6NPFF, TAC1
4positive regulation of ossificationGO:004577810.6OXT, TAC1
5response to painGO:004826510.6TAC1, TRPV1
6negative regulation of appetiteGO:003209910.5CCK, NPFF
7opioid receptor signaling pathwayGO:003800310.5OPRK1, OPRL1, OPRM1
8estrous cycleGO:004484910.5OPRK1, OPRL1, OPRM1
9response to foodGO:003209410.5OPRM1, OXT
10negative regulation of cAMP biosynthetic processGO:003081810.5OPRL1, OPRM1
11acute inflammatory response to antigenic stimulusGO:000243810.5NPFF, OPRM1
12adenylate cyclase-inhibiting G-protein coupled receptor signaling pathwayGO:000719310.4OPRK1, OPRL1, OPRM1
13positive regulation of blood pressureGO:004577710.2CNR1, NPFF, OXT
14maternal behaviorGO:004271110.2OPRK1, OXT
15G-protein coupled receptor signaling pathway, coupled to cyclic nucleotide second messengerGO:000718710.1CNR1, HTR7, OPRM1
16positive regulation of apoptotic processGO:004306510.0CCK, CNR1, PSENEN, TRPV1
17sensory perceptionGO:000760010.0OPRK1, OPRL1, OPRM1, PDYN, PNOC
18positive regulation of renal sodium excretionGO:003581510.0OXT, TAC1
19eating behaviorGO:00427559.9CCK, OPRK1, OPRL1, OPRM1, OXT
20response to ethanolGO:00454719.9CNR1, OPRK1, OPRM1
21negative regulation of blood pressureGO:00457769.8CNR1, OPRL1, OXT
22positive regulation of cytosolic calcium ion concentrationGO:00072049.8NPFF, OPRL1, OXT, TAC1, TRPV1
23sensory perception of painGO:00192339.7CNR1, OPRK1, OPRL1, OPRM1, TAC1, TRPV1
24response to cocaineGO:00422209.7CNR1, OPRK1, OPRM1, OXT
25regulation of sensory perception of painGO:00519309.6CCK, NPFF, OPRK1, OPRL1, OPRM1, OXT
26neuropeptide signaling pathwayGO:00072189.3NPFF, OPRK1, OPRL1, OPRM1, PDYN, PNOC
27response to morphineGO:00432789.1CNR1, NPFF, OPRK1, OPRM1, TAC1
28chemical synaptic transmissionGO:00072689.1HTR7, NPFF, OPRK1, OPRL1, OPRM1, PDYN

Molecular functions related to Agnosia according to GeneCards Suite gene sharing:

idNameGO IDScoreTop Affiliating Genes
1opioid receptor activityGO:000498510.3OPRK1, OPRM1
2opioid receptor bindingGO:003162810.3PDYN, PNOC
3neuropeptide bindingGO:004292310.3OPRK1, OPRL1, OPRM1
4opioid peptide activityGO:00015159.9PDYN, PNOC
5neuropeptide hormone activityGO:00051849.1CCK, NPFF, OXT, PDYN, PNOC, POMC

Sources for Agnosia

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2CDC
6CNVD
10DGIdb
15ExPASy
16FDA
17FMA
26GTR
27HGMD
28HMDB
29ICD10
30ICD10 via Orphanet
31ICD9CM
32IUPHAR
33KEGG
36MedGen
38MeSH
39MESH via Orphanet
40MGI
43NCI
44NCIt
45NDF-RT
48NINDS
49Novoseek
51OMIM
52OMIM via Orphanet
56PubMed
57QIAGEN
62SNOMED-CT via Orphanet
66Tumor Gene Family of Databases
67UMLS
68UMLS via Orphanet