MCID: AGN002
MIFTS: 51

Agnosia malady

Eye diseases category

Summaries for Agnosia

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Sources:
8Disease Ontology, 42NIH Rare Diseases, 43NINDS, 63Wikipedia, 32MalaCards
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NINDS:43 Agnosia is a rare disorder characterized by an inability to recognize and identify objects or persons. People with agnosia may have difficulty recognizing the geometric features of an object or face or may be able to perceive the geometric features but not know what the object is used for or whether a face is familiar or not. Agnosia can be limited to one sensory modality such as vision or hearing. For example, a person may have difficulty in recognizing an object as a cup or identifying a sound as a cough. Agnosia can result from strokes, dementia, developmental disorders, or other neurological conditions. It typically results from damage to specific brain areas in the occipital or parietal lobes of the brain. People with agnosia may retain their cognitive abilities in other areas.

MalaCards: Agnosia, also known as dyspraxia, is related to visual agnosia and associative agnosia. An important gene associated with Agnosia is BBS2 (Bardet-Biedl syndrome 2), and among its related pathways are Neuropeptides signaling through G-protein alpha-i & G-protein alpha-q and Class A/1 (Rhodopsin-like receptors). The compounds ufp-101 and ban orl 24 have been mentioned in the context of this disorder. Affiliated tissues include brain, parietal lobe and eye, and related mouse phenotype integument.

Disease Ontology:8 A communication disorder that is a loss of ability to recognize objects, persons, sounds, shapes, or smells while the specific sense is not defective nor is there any significant memory loss.

NIH Rare Diseases:42 Agnosia is characterized by an inability to recognize and identify objects and/or persons. symptoms may vary, according to the area of the brain that is affected. it can be limited to one sensory modality such as vision or hearing; for example, a person may have difficulty in recognizing an object as a cup or identifying a sound as a cough. agnosia can result from strokes, traumatic brain injury, dementia, a tumor, developmental disorders, overexposure to environmental toxins (e.g., carbon monoxide poisoning), or other neurological conditions. visual agnosia may also occur in association with other underlying disorders. people with agnosia may retain their cognitive abilities in other areas. treatment of primary agnosia is symptomatic and supportive; when it is caused by an underlying disorder, treatment of the disorder may reduce symptoms and help prevent further brain damage. last updated: 4/22/2011

Wikipedia:63 Agnosia (from Ancient Greek ἀγνωσία agnosia, \"ignorance\", \"absence of knowledge\") is a loss... more...

Aliases & Classifications for Agnosia

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8Disease Ontology, 42NIH Rare Diseases, 43NINDS, 60UMLS, 56SNOMED-CT, 34MeSH, 39NCIt, 25ICD10
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Classifications:

Malacards categories (disease lists): (See all malacards categories)
Anatomical: Eye diseases


Aliases & Descriptions:

agnosia 8 42 43 60
dyspraxia 8 43
monomodal visual amnesia 42
primary visual agnosia 42
dyspraxia syndrome 8
visual amnesia 42


Related Diseases for Agnosia

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17GeneCards, 18GeneDecks
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Graphical network of the top 20 diseases related to Agnosia:



Diseases related to agnosia

Clinical Features for Agnosia

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Drugs & Therapeutics for Agnosia

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Sources:
5CenterWatch, 41NIH Clinical Center, 6ClinicalTrials
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Approved drugs:

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Drug clinical trials:

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Genetic Tests for Agnosia

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Anatomical Context for Agnosia

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32MalaCards
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MalaCards organs/tissues related to Agnosia:

32
Brain, Parietal lobe, Eye, Temporal lobe, Cortex, Testes, T cells

Animal Models for Agnosia or affiliated genes

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Sources:
36MGI
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MGI Mouse Phenotypes related to Agnosia:

36
idDescriptionMGI Source AccessionScoreTop Affiliating Genes
1MP:001077110.1SP6, PNOC, OPRL1, JAG2, PDYN, LSR

Publications for Agnosia

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50PubMed
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Articles related to Agnosia:

(show top 50)    (show all 370)
idTitleAuthorsYear
1
Corticobasal syndrome presenting with partial Gerstmann's syndrome and digit agnosia. (23686076)
2013
2
Auditory agnosia in a patient with nephrotic syndrome. (23322309)
2013
3
A case of complex regional pain syndrome with agnosia for object orientation. (21450404)
2011
4
Integration of tactile input across fingers in a patient with finger agnosia. (21095197)
2011
5
Memory-guided saccade processing in visual form agnosia (patient DF). (19904528)
2010
6
Nonverbal auditory agnosia with lesion to Wernicke's area. (19698727)
2010
7
Associative visual agnosia: a case study. (18413915)
2008
8
A case of tactile agnosia with a lesion restricted to the post-central gyrus. (19127044)
2008
9
A tale of two agnosias: distinctions between form and integrative agnosia. (18340604)
2008
10
Chapter 21 Visual agnosia. (18631704)
2008
11
Impairments in part-whole representations of objects in two cases of integrative visual agnosia. (18066732)
2007
12
Pure agnosia for mirror stimuli after right inferior parietal lesion. (12615647)
2003
13
Category-specific visual agnosia: lesion to semantic memory versus extra-lesional variables in a case study and a connectionist model. (14642293)
2003
14
Vertical gaze angle as a distance cue for programming reaching: insights from visual form agnosia II (of III). (11497054)
2001
15
A new paradigm for investigating category-specific agnosia in the new millennium. (10739622)
2000
16
Number processing and calculation in a case of visual agnosia. (10921666)
2000
17
Neuropathology of auditory agnosia following bilateral temporal lobe lesions: a case study. (11603786)
2000
18
Auditory agnosia and auditory spatial deficits following left hemispheric lesions: evidence for distinct processing pathways. (10689055)
2000
19
Patterns of music agnosia associated with middle cerebral artery infarcts. (10960056)
2000
20
Neuroanatomic correlates of visual agnosia in Alzheimer's disease: a clinicopathologic study. (9921851)
1999
21
Separate visual pathways for perception of actions and objects: evidence from a case of apperceptive agnosia. (9728957)
1998
22
What Is Special about Face Recognition? Nineteen Experiments on a Person with Visual Object Agnosia and Dyslexia but Normal Face Recognition. (23965118)
1997
23
When is a view unusual? A single case study of orientation-dependent visual agnosia. (8886380)
1996
24
Progressive visual agnosia with posterior cortical atrophy. (8836594)
1996
25
Prosopagnosia without topographagnosia and object agnosia associated with a lesion confined to the right occipitotemporal region. (7964914)
1994
26
Associative visual agnosia and alexia without prosopagnosia. (7805382)
1994
27
Intact visual imagery and impaired visual perception in a patient with visual agnosia. (7964528)
1994
28
The fuzzy boundaries of apperceptive agnosia. (8348820)
1993
29
Selective loss of imagery in a case of visual agnosia. (1528412)
1992
30
Parallel pattern processing and visual agnosia. (1486552)
1992
31
Tactile agnosia and tactile aphasia: symptomatological and anatomical differences. (1382919)
1992
32
The role of sensorimotor experience in object recognition. A case of multimodal agnosia. (1782531)
1991
33
Speech discrimination and lip reading in patients with word deafness or auditory agnosia. (2036580)
1991
34
Prosopagnosia and object agnosia without covert recognition. (2927628)
1989
35
A case of associative visual agnosia: neuropsychological findings and theoretical considerations. (2808655)
1989
36
Pure word deafness (acquired verbal auditory agnosia) in an Arabic speaking patient. (3378145)
1988
37
Visual agnosia and amnesia from a left unilateral lesion. (3416893)
1988
38
Non-conscious face recognition in patients with face agnosia. (3178995)
1988
39
A case of integrative visual agnosia. (3427396)
1987
40
Apperceptive agnosia due to carbon monoxide poisoning. An interpretation based on critical band masking from disseminated lesions. (4005031)
1985
41
Visual agnosia without alexia. (6539870)
1984
42
Taste agnosia following gustatory neocortex ablation: dissociation from odor and generality across taste qualities. (6540588)
1984
43
Prosopo-affective agnosia and computerized tomography findings in patients with cerebral disorders. (7419850)
1980
44
Prosopo-affective agnosia associated with chronic organic brain syndrome. (762371)
1979
45
Distinctive features of unilateral spatial agnosia in right and left brain-damaged patients. (615703)
1977
46
The unilateral forms of finger agnosia. An experimental study. (4760043)
1973
47
VISUAL STATIC AGNOSIA WITH SPECIAL REFERENCE TO LITERAL AGNOSIC ALEXIA. (14239096)
1964
48
Clumsy children: developmental apraxia and agnosia. (13998739)
1962
49
Sensory deprivation, sensory suppression and agnosia: notes for a neurologic theory. (13776128)
1961
50
A further study of visual-spatial agnosia. (13471805)
1957

Genetic Variations for Agnosia

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Expression for genes affiliated with Agnosia

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1BioGPS, 15Gene Expression Omnibus DataSets
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Expression patterns in normal tissues for genes affiliated with Agnosia

Search GEO for disease gene expression data for Agnosia.

Pathways for genes affiliated with Agnosia

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12EMD Millipore, 37NCBI BioSystems Database, 53Reactome, 29KEGG
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Compounds for genes affiliated with Agnosia

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59Tocris Bioscience, 28IUPHAR, 44Novoseek, 11DrugBank, 49PharmGKB, 24HMDB
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Compounds related to Agnosia according to GeneCards/GeneDecks:

(show all 21)
idCompoundScoreTop Affiliating Genes
1ufp-10159 2811.6PNOC, OPRL1
2ban orl 245910.6OPRL1, PNOC
3npff4410.6PNOC, PDYN, NPFF
4damgo44 59 2812.6PDYN, OPRL1, PNOC
5etorphine44 28 1112.6OPRL1, PNOC, PDYN
6nociceptin5910.6PNOC, OPRL1
7(+-)-j 1133975910.6OPRL1, PNOC
8buprenorphine44 28 1112.6PDYN, PNOC, OPRL1
9jtc 8015910.6OPRL1, PNOC
10tetrapeptide4410.6CCKAR, NPFF, PNOC, OPRL1
11nalbzoh4410.6OPRL1, PNOC
12opiate4410.5OPRL1, PDYN, PNOC, NPFF
13morphine44 49 28 1113.5NPFF, CCKAR, PDYN, OPRL1, PNOC
14naltrindole44 2811.5NPFF, PNOC
15norbinaltorphimine4410.5PDYN, PNOC
16[3h]diprenorphine4410.5PDYN, PNOC
17atropine44 28 1112.4CCKAR, PDYN, PNOC
18naltrexone44 49 28 1113.4OPRL1, PNOC
19dpdpe28 44 5912.3PDYN, PNOC
20cyclic amp44 2411.1OPRL1, PNOC, NPFF, NPVF, CCKAR
21cocaine44 1111.0CCKAR, PNOC, PDYN

GO Terms for genes affiliated with Agnosia

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16Gene Ontology
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Biological processes related to Agnosia according to GeneCards/GeneDecks:

idNameGO IDScoreTop Affiliating Genes
1elevation of cytosolic calcium ion concentrationGO:00720410.3OPRL1, NPFF, CCKAR
2neuropeptide signaling pathwayGO:00721810.1PNOC, NPFF, NPVF, PDYN
3sensory perceptionGO:00760010.1PNOC, OPRL1

Molecular functions related to Agnosia according to GeneCards/GeneDecks:

idNameGO IDScoreTop Affiliating Genes
1neuropeptide hormone activityGO:00518410.3PNOC, NPFF
2opioid peptide activityGO:00151510.0PNOC, PDYN

Products for genes affiliated with Agnosia

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Sources for Agnosia

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3CDC
13ExPASy
14FMA
22GTR
23HGMD
24HMDB
25ICD10
26ICD10 via Orphanet
27ICD9CM
28IUPHAR
29KEGG
34MeSH
35MESH via Orphanet
36MGI
39NCIt
40NDF-RT
43NINDS
44Novoseek
46OMIM
47OMIM via Orphanet
50PubMed
51QIAGEN
57SNOMED-CT via Orphanet
60UMLS
61UMLS via Orphanet