MCID: AGN002
MIFTS: 45

Agnosia malady

Categories: Rare diseases, Fetal diseases, Eye diseases

Aliases & Classifications for Agnosia

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Aliases & Descriptions for Agnosia:

Name: Agnosia 10 45 46 12 36 65
Primary Visual Agnosia 45 65
Dyspraxia 10 46
Apraxias 36 65
 
Monomodal Visual Amnesia 45
Dyspraxia Syndrome 10
Visual Amnesia 45
Alexia 65

Classifications:



External Ids:

Disease Ontology10 DOID:4090
ICD1027 R48.1, R48.2
NCIt42 C84542
UMLS65 C0001816, C0003635

Summaries for Agnosia

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NIH Rare Diseases:45 Agnosia is characterized by an inability to recognize and identify objects and/or persons. symptoms may vary, according to the area of the brain that is affected. it can be limited to one sensory modality such as vision or hearing; for example, a person may have difficulty in recognizing an object as a cup or identifying a sound as a cough. agnosia can result from strokes, traumatic brain injury, dementia, a tumor, developmental disorders, overexposure to environmental toxins (e.g., carbon monoxide poisoning), or other neurological conditions. visual agnosia may also occur in association with other underlying disorders. people with agnosia may retain their cognitive abilities in other areas. treatment of primary agnosia is symptomatic and supportive; when it is caused by an underlying disorder, treatment of the disorder may reduce symptoms and help prevent further brain damage. last updated: 4/22/2011

MalaCards based summary: Agnosia, also known as primary visual agnosia, is related to drug dependence and panuveitis. An important gene associated with Agnosia is OPRM1 (Opioid Receptor Mu 1), and among its related pathways are Syndecan-3-mediated signaling events and Peptide ligand-binding receptors. Affiliated tissues include brain, parietal lobe and breast, and related mouse phenotypes are adipose tissue and integument.

Disease Ontology:10 A communication disorder that is a loss of ability to recognize objects, persons, sounds, shapes, or smells while the specific sense is not defective nor is there any significant memory loss.

NINDS:46 Agnosia is a rare disorder characterized by an inability to recognize and identify objects or persons. People with agnosia may have difficulty recognizing the geometric features of an object or face or may be able to perceive the geometric features but not know what the object is used for or whether a face is familiar or not. Agnosia can be limited to one sensory modality such as vision or hearing. For example, a person may have difficulty in recognizing an object as a cup or identifying a sound as a cough. Agnosia can result from strokes, dementia, developmental disorders, or other neurological conditions. It typically results from damage to specific brain areas in the occipital or parietal lobes of the brain. People with agnosia may retain their cognitive abilities in other areas.

Wikipedia:68 Agnosia is the inability to process sensory information. Often there is a loss of ability to recognize... more...

Related Diseases for Agnosia

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Diseases in the Agnosia family:

Form Agnosia

Diseases related to Agnosia via text searches within MalaCards or GeneCards Suite gene sharing:

(show top 50)    (show all 355)
idRelated DiseaseScoreTop Affiliating Genes
1drug dependence30.5CNR1, OPRM1, POMC
2panuveitis30.4CNR1, HTR2A, HTR7
3trichinosis30.4HTR2A, HTR7, TRPV1
4candidiasis29.7CNR1, HTR2A, HTR7, OPRM1, OXT, PDYN
5phonagnosia27.5AP1M2, AP2M1, CNR1, HTR2A, HTR7, NOL3
6ataxia, early-onset, with oculomotor apraxia and hypoalbuminemia12.7
7rolandic epilepsy, mental retardation, and speech dyspraxia12.6
8visual agnosia12.5
9developmental dyspraxia12.4
10auditory agnosia12.4
11tactile agnosia12.4
12topographical agnosia12.4
13apperceptive agnosia12.4
14social emotional agnosia12.4
15finger agnosia12.4
16verbal auditory agnosia12.4
17associative agnosia12.4
18form agnosia12.4
19pain agnosia12.4
20time agnosia12.4
21integrative agnosia12.3
22color agnosia12.3
23mirror agnosia12.3
24semantic agnosia12.3
25visual verbal agnosia12.3
26rolandic epilepsy-speech dyspraxia syndrome12.3
27childhood apraxia of speech11.8
28astereognosia11.8
29epilepsy, focal, with speech disorder and with or without mental retardation11.8
30autotopagnosia11.6
31alexithymia10.6
32apraxia10.6
33alexia10.6
34retrograde amnesia10.6HTR2A, POMC
35mesenchymal chondrosarcoma10.6PDYN, POMC
36smooth muscle tumor10.6HTR2A, POMC
37histiocytosis10.6HTR2A, POMC
38tic disorder10.5CNR1, HTR2A
39phimosis10.5POMC, TRPV1
40buphthalmos10.5OPRM1, PDYN
41autoimmune enteropathy10.5CNR1, TRPV1
42xerophthalmia10.5HTR2A, HTR7
43liver leiomyoma10.5HTR2A, HTR7
44hemangioma of spleen10.5OPRM1, PDYN, POMC
45spastic paraplegia 46, autosomal recessive10.5APTX, SETX
46muscular dystrophy, limb-girdle, type 2c10.5APTX, SETX
47olfactory nerve disease10.5PDYN, POMC
48lobomycosis10.5PDYN, PSENEN
49hematocele of tunica vaginalis testis10.5HTR2A, OXT
50prostatocystitis10.5HTR2A, OXT

Graphical network of the top 20 diseases related to Agnosia:



Diseases related to agnosia

Symptoms for Agnosia

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Drugs & Therapeutics for Agnosia

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Drugs for Agnosia (from DrugBank, HMDB, Dgidb, PharmGKB, IUPHAR, NovoSeek, BitterDB):

idNameStatusPhaseClinical TrialsCas NumberPubChem Id
1
OxytocinapprovedPhase 036650-56-6439302, 53477758
Synonyms:
(2S)-1-[(4R,7S,10S,13S,16S,19R)-19-amino-7-(2-amino-2-oxoethyl)-10-(3-amino-3-oxopropyl)-13-[(2S)-butan-2-yl]-16-[(4-hydroxyphenyl)methyl]-6,9,12,15,18-pentaoxo-1,2-dithia-5,8,11,14,17-pentazacycloicosane-4-carbonyl]-N-[(2S)-1-[(2-amino-2-oxoethyl)amino]-4-methyl-1-oxopentan-2-yl]pyrrolidine-2-carboxamide
(Arg8)-Vasopressin
(Arg8)-Vasotocin
1-({(4R,7S,10S,13S,16S,19R)-19-amino-7-(2-amino-2-oxoethyl)-10-(3-amino-3-oxopropyl)-16-(4-hydroxybenzyl)-13-[(1S)-1-methylpropyl]-6,9,12,15,18-pentaoxo-1,2-dithia-5,8,11,14,17-pentaazacycloicosan-4-yl}carbonyl)-L-prolyl-L-leucylglycinamide
50-56-6
AC1L9735
Argipressin
Argpressin Acetate
BCBcMAP01_000094
Biotinyl-(Arg8)-Vasopressin
C00746
CHEBI:492195
CHEBI:7872
CHEMBL395429
CID439302
Cys-Tyr-Ile-Gln-Asn-Cys-Pro-Arg-Gly-NH2
Cys-Tyr-Ile-Gln-Asn-Cys-Pro-Leu-Gly-NH2
Cys-Tyr-Ile-Thr-Asn-Cys-Gly-Leu-Gly-NH2
Cys-Tyr-Phe-Gln-Asn-Cys-Pro-Arg-Gly-NH2
Cys-Tyr-Phe-Gln-Asn-Cys-Pro-Lys-Gly-NH2
D00089
Disulfide bridge Cys1-Cys6
Gly-Leu-Pro-c
HS-2021
L-Cysteinyl-L-tyrosyl-L-isoleucyl-L-glutaminyl-L-asparaginyl-L-cysteinyl-L-prolyl-L-leucylglycinamide cyclic(1-6)-disulfide
MolPort-003-938-941
 
NCGC00167132-01
O3251_SIGMA
O4375_SIGMA
OXT
OXYTOCIN
Ocytocin
Oxitocina
Oxytocic hormone
Oxytocin
Oxytocin (JP15/USP/INN)
Oxytocin (TN)
Oxytocin 10 Usp Units In Dextrose 5%
Oxytocin 20 Usp Units In Dextrose 5%
Oxytocin 5 Usp Units In Dextrose 5%
Oxytocin Acetate
Oxytocin injection
Oxytocine
Oxytocinum
Pitocin
Pitocin (TN)
SID29217903
SID50111741
Syntocinon
Syntocinon (TN)
TI-001
alpha-Hypophamine
nchembio.184-comp2

Interventional clinical trials:

idNameStatusNCT IDPhase
1Orientation Agnosia: Clinical and Anatomical StudyCompletedNCT01304576
2Functional Magnetic Resonance Imaging (fMRI) of Anosognosia in Amnestic Mild Cognitive Impairment (MCI) and Alzheimer's Disease (AD)CompletedNCT00908999
3Lack of Awareness of Symptoms (Anosognosia) in PD: An Observational Study for People With Parkinson'sRecruitingNCT02561715
4The Effect of Oxytocin on Face PerceptionSuspendedNCT02091817Phase 0

Search NIH Clinical Center for Agnosia


Cochrane evidence based reviews: agnosia

Genetic Tests for Agnosia

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Anatomical Context for Agnosia

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MalaCards organs/tissues related to Agnosia:

33
Brain, Parietal lobe, Breast, Liver, Lung, Prostate, Bone

Animal Models for Agnosia or affiliated genes

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MGI Mouse Phenotypes related to Agnosia:

38
idDescriptionMGI Source AccessionScoreTop Affiliating Genes
1MP:00053759.5CNR1, OPRM1, OXT, PDYN, POMC, TRPV1
2MP:00107718.5CNR1, HTR7, OPRL1, OPRM1, OXT, PDYN
3MP:00053868.0CNR1, HTR2A, HTR7, OPRL1, OPRM1, OXT

Publications for Agnosia

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Articles related to Agnosia:

(show top 50)    (show all 398)
idTitleAuthorsYear
1
Sclerosing mucoepidermoid carcinoma with eosinophilia of the thyroid: more aggressive than previously reported. (25754017)
2015
2
Cystinosis in adult and adolescent patients: Recommendations for the comprehensive care of cystinosis. (26523297)
2015
3
CTLA4 overexpressing adipose tissue-derived mesenchymal stem cell therapy in a dog with steroid-refractory pemphigus foliaceus. (25889154)
2015
4
Inflammatory Myofibroblastic Tumor Arising in the Pancreatic Head: a Rare Case Report. (26884665)
2015
5
Beneficial Effect of Protein Tyrosine Phosphatase Inhibitor and Phytoestrogen in Dyslipidemia-Induced Vascular Dementia in Ovariectomized Rats. (26324516)
2015
6
Appendicitis-like clinical image elicited by Enterobius vermicularis: case report and review of the literature. (23741933)
2013
7
Pathological features of polyneuropathy in three dogs. (23123885)
2013
8
COSMC is overexpressed in proliferating infantile hemangioma and enhances endothelial cell growth via VEGFR2. (23424651)
2013
9
Abdominal fibromatosis in a young child: a case study and review of the literature. (24255636)
2013
10
Reconstruction of the right atrium using an extracellular matrix patch in a patient with severe mediastinal aspergillosis. (23376511)
2013
11
The production and regulation of IGF and IGFBPs in human adipose tissue cultures. (23079385)
2012
12
Nevirapine induced exfoliative dermatitis in an HIV-infected patient. (22144790)
2011
13
Cloning and characterization of the osteoarthritis-associated gene DVWA. (21057832)
2011
14
No-patch technique for complete atrioventricular canal repair. (20609816)
2010
15
Replication of LCE3C-LCE3B CNV as a risk factor for psoriasis and analysis of interaction with other genetic risk factors. (20016497)
2010
16
The C-terminal domain of Cernunnos/XLF is dispensable for DNA repair in vivo. (19103754)
2009
17
Soy isoflavones have an antiestrogenic effect and alter mammary promoter hypermethylation in healthy premenopausal women. (19235040)
2009
18
Tyrosine sulfation: an increasingly recognised post-translational modification of secreted proteins. (19658209)
2009
19
Functional assessment of allelic variants in the SLC26A4 gene involved in Pendred syndrome and nonsyndromic EVA. (19017801)
2008
20
CCAR1, a key regulator of mediator complex recruitment to nuclear receptor transcription complexes. (18722177)
2008
21
Induction of epidermal growth factor receptor expression by Epstein-Barr virus latent membrane protein 1 C-terminal-activating region 1 is mediated by NF-kappaB p50 homodimer/Bcl-3 complexes. (17881446)
2007
22
Anal and ano-urogenital malformations: a histopathological study of "imperforate anus" with a reconstruction of the pathogenesis. (17535093)
2007
23
Rash as a surrogate marker for efficacy of epidermal growth factor receptor inhibitors in lung cancer. (17239291)
2006
24
The interleukin-6 -174G/C promoter polymorphism is not associated with endometriosis in South Indian women. (15979549)
2005
25
Histiocytoid breast carcinoma: solid variant of invasive lobular carcinoma with decreased expression of both E-cadherin and CD44 epithelial variant. (15943793)
2005
26
Cerebellar hypoplasia with heterotopic purkinje cells in the molecular layer and preservation of the granule layers associated with severe encephalopathy. A new entity? (12910442)
2003
27
Relationship between XPG codon 1104 polymorphism and risk of primary lung cancer. (12869423)
2003
28
Expression of cysteine dioxygenase (EC 1.13.11.20) and sulfite oxidase in the human lung: a potential role for sulfate production in the protection from airborne xenobiotica. (14514920)
2003
29
Intervention by retinoic acid in oxidative stress-induced apoptosis. (12386300)
2002
30
Force spectroscopy of single biomolecules. (12503171)
2002
31
Prenatal diagnosis of mosaicism for triploidy and trisomy 13. (11438949)
2001
32
Squamous cell carcinoma of the tongue after bone marrow transplantation in a patient with Fanconi's anemia. (11117702)
2000
33
Gallbladder carcinomas: an immunoprognostic evaluation of P53, Bcl-2, CEA and alpha-fetoprotein. (10758414)
2000
34
Expression of endothelial nitric oxide synthase, inducible nitric oxide synthase, and endothelin-1 in lungs of subjects who died with ARDS. (10424623)
1999
35
Detection of humoral rejection in human cardiac allografts by assessing the capillary deposition of complement fragment C4d in endomyocardial biopsies. (10528753)
1999
36
Biochemical and physical properties of remnant-HDL2 and of pre beta 1-HDL produced by hepatic lipase. (10052947)
1999
37
Increased biochemical markers of bone formation and resorption in primary hyperparathyroidism with special reference to patients with mild disease. (9566639)
1998
38
Transforming growth factor beta in fracture repair. (9917633)
1998
39
Interleukin-3 priming in acute myeloid leukaemia patients. (7577641)
1995
40
Management of otitis externa. (7817494)
1994
41
Protective effects of basic fibroblast growth factor against hippocampal neuronal damage following cerebral ischemia in the gerbil. (8481788)
1993
42
A comparative study of tear secretion in blepharospasm and hemifacial spasm patients treated with botulinum toxin. (8501266)
1993
43
Antagonism of prolactin binding by cyclosporine A on MCF7 breast tumour cell line. (1776854)
1991
44
Predominant sensory Guillain-BarrAc syndrome in hereditary sensory neuropathy--case report of a three-year-old boy. (6588305)
1984
45
Prolonged survival in tricuspid atresia with Eisenmenger's physiology. (6488600)
1984
46
Studies on the inhibitory action of opiate compounds in isolated bovine adrenal chromaffin cells: noninvolvement of stereospecific opiate binding sites. (6259293)
1981
47
Null cell (non-T, non-B) acute lymphoblastic leukemia terminating as malignant histiocytosis. (6929651)
1980
48
The slow spike-wave complex as a correlate of frontal and fronto-temporal post-traumatic epilepsy. (4988908)
1970
49
50

Variations for Agnosia

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Expression for genes affiliated with Agnosia

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Search GEO for disease gene expression data for Agnosia.

Pathways for genes affiliated with Agnosia

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GO Terms for genes affiliated with Agnosia

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Cellular components related to Agnosia according to GeneCards Suite gene sharing:

idNameGO IDScoreTop Affiliating Genes
1clathrin adaptor complexGO:003013110.1AP1M2, AP2M1
2dendriteGO:00304259.4HTR2A, OPRM1, PDYN, PNOC, TRPV1
3cytosolGO:00058298.5HTR2A, NOL3, OPRL1, OPRM1, OXT, RPL34

Biological processes related to Agnosia according to GeneCards Suite gene sharing:

(show all 16)
idNameGO IDScoreTop Affiliating Genes
1mRNA splice site selectionGO:000637610.5NOL3, SETX
2urinary bladder smooth muscle contractionGO:001483210.5HTR2A, TRPV1
3sensory perceptionGO:000760010.4OPRL1, OPRM1
4eating behaviorGO:004275510.4OPRM1, OXT
5smooth muscle contractionGO:000693910.3HTR2A, HTR7
6positive regulation of renal sodium excretionGO:003581510.3OXT, TAC1
7positive regulation of ossificationGO:004577810.2OXT, TAC1
8cellular response to nerve growth factor stimulusGO:199009010.2TAC1, TRPV1
9regulation of sensory perception of painGO:005193010.2OPRL1, OPRM1, OXT
10positive regulation of blood pressureGO:004577710.1CNR1, OXT
11negative regulation of cAMP biosynthetic processGO:003081810.0OPRL1, OPRM1
12negative regulation of blood pressureGO:004577610.0CNR1, OPRL1, OXT
13response to cocaineGO:00422209.8CNR1, OPRM1, OXT
14memoryGO:00076139.5CNR1, HTR2A, OXT
15synaptic transmissionGO:00072689.2AP2M1, HTR2A, OPRL1, OPRM1, TAC1
16sensory perception of painGO:00192339.1CNR1, HTR2A, OPRL1, OPRM1, TAC1, TRPV1

Molecular functions related to Agnosia according to GeneCards Suite gene sharing:

idNameGO IDScoreTop Affiliating Genes
1opioid peptide activityGO:000151510.0PDYN, PNOC

Sources for Agnosia

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2CDC
14ExPASy
15FDA
16FMA
24GTR
25HGMD
26HMDB
27ICD10
28ICD10 via Orphanet
29ICD9CM
30IUPHAR
31KEGG
34MedGen
36MeSH
37MESH via Orphanet
38MGI
41NCI
42NCIt
43NDF-RT
46NINDS
47Novoseek
49OMIM
50OMIM via Orphanet
54PubMed
55QIAGEN
60SNOMED-CT via Orphanet
64Tumor Gene Family of Databases
65UMLS
66UMLS via Orphanet