MCID: AGN002
MIFTS: 51

Agnosia malady

Eye diseases category

Summaries for Agnosia

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Sources:
8Disease Ontology, 42NIH Rare Diseases, 43NINDS, 63Wikipedia, 32MalaCards
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NINDS:43 Agnosia is a rare disorder characterized by an inability to recognize and identify objects or persons. People with agnosia may have difficulty recognizing the geometric features of an object or face or may be able to perceive the geometric features but not know what the object is used for or whether a face is familiar or not. Agnosia can be limited to one sensory modality such as vision or hearing. For example, a person may have difficulty in recognizing an object as a cup or identifying a sound as a cough. Agnosia can result from strokes, dementia, developmental disorders, or other neurological conditions. It typically results from damage to specific brain areas in the occipital or parietal lobes of the brain. People with agnosia may retain their cognitive abilities in other areas.

MalaCards: Agnosia, also known as dyspraxia, is related to visual agnosia and associative agnosia. An important gene associated with Agnosia is BBS2 (Bardet-Biedl syndrome 2), and among its related pathways are Neuropeptides signaling through G-protein alpha-i & G-protein alpha-q and Class A/1 (Rhodopsin-like receptors). The compounds ufp-101 and ban orl 24 have been mentioned in the context of this disorder. Affiliated tissues include brain, parietal lobe and eye, and related mouse phenotype integument.

Disease Ontology:8 A communication disorder that is a loss of ability to recognize objects, persons, sounds, shapes, or smells while the specific sense is not defective nor is there any significant memory loss.

NIH Rare Diseases:42 Agnosia is characterized by an inability to recognize and identify objects and/or persons. symptoms may vary, according to the area of the brain that is affected. it can be limited to one sensory modality such as vision or hearing; for example, a person may have difficulty in recognizing an object as a cup or identifying a sound as a cough. agnosia can result from strokes, traumatic brain injury, dementia, a tumor, developmental disorders, overexposure to environmental toxins (e.g., carbon monoxide poisoning), or other neurological conditions. visual agnosia may also occur in association with other underlying disorders. people with agnosia may retain their cognitive abilities in other areas. treatment of primary agnosia is symptomatic and supportive; when it is caused by an underlying disorder, treatment of the disorder may reduce symptoms and help prevent further brain damage. last updated: 4/22/2011

Wikipedia:63 Agnosia (from Ancient Greek ἀγνωσία agnosia, \"ignorance\", \"absence of knowledge\") is a loss... more...

Aliases & Classifications for Agnosia

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8Disease Ontology, 42NIH Rare Diseases, 43NINDS, 60UMLS, 56SNOMED-CT, 34MeSH, 39NCIt, 25ICD10
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Classifications:

Malacards categories (disease lists): (See all malacards categories)
Anatomical: Eye diseases


Aliases & Descriptions:

agnosia 8 42 43 60
dyspraxia 8 43
monomodal visual amnesia 42
primary visual agnosia 42
dyspraxia syndrome 8
visual amnesia 42


Related Diseases for Agnosia

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17GeneCards, 18GeneDecks
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Graphical network of the top 20 diseases related to Agnosia:



Diseases related to agnosia

Clinical Features for Agnosia

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Drugs & Therapeutics for Agnosia

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Sources:
5CenterWatch, 41NIH Clinical Center, 6ClinicalTrials
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Approved drugs:

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Drug clinical trials:

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Genetic Tests for Agnosia

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Anatomical Context for Agnosia

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32MalaCards
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MalaCards organs/tissues related to Agnosia:

32
Brain, Parietal lobe, Eye, Temporal lobe, Cortex, Testes, T cells

Animal Models for Agnosia or affiliated genes

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36MGI
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MGI Mouse Phenotypes related to Agnosia:

36
idDescriptionMGI Source AccessionScoreTop Affiliating Genes
1MP:001077110.1SP6, PNOC, OPRL1, JAG2, PDYN, LSR

Publications for Agnosia

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50PubMed
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Articles related to Agnosia:

(show top 50)    (show all 370)
idTitleAuthorsYear
1
Acquired auditory agnosia in childhood and normal sleep electroencephalography subsequently diagnosed as Landau-Kleffner syndrome: a report of three cases. (23121226)
2013
2
The right place at the right time: priming facial expressions with emotional face components in developmental visual agnosia. (22349446)
2012
3
Psychic blindness or visual agnosia: early descriptions of a nervous disorder. (21253940)
2011
4
Left hand tactile agnosia after posterior callosal lesion. (18589409)
2008
5
Specular right-left disorientation, finger-agnosia, and asomatognosia in right hemisphere stroke. (17846515)
2007
6
Associative (prosop)agnosia without (apparent) perceptual deficits: a case-study. (17320120)
2007
7
Characteristics of auditory agnosia in a child with severe traumatic brain injury: a case report. (15582032)
2005
8
Gustatory agnosia. (15668430)
2005
9
Section IV: Three As: Alexia, agraphia, agnosia. (21038211)
2004
10
Visual agnosia. (12916489)
2003
11
Agnosia for global patterns: When the cross-talk between grouping and visual selective attention failS. (20957562)
2003
12
Implicit face perception in a patient with visual agnosia? Evidence from behavioural and eye-tracking analyses. (12591027)
2003
13
Music agnosia and auditory agnosia. Dissociations in stroke patients. (14681117)
2003
14
Visual object agnosia as a problem in integrating parts and part relations. (12030502)
2002
15
Dynamic visual speech perception in a patient with visual form agnosia. (12395125)
2002
16
The real-object advantage in agnosia: Evidence for a role of surface and depth information in object recognition. (20945210)
2001
17
Auditory agnosia restricted to environmental sounds following cortical deafness and generalized auditory agnosia. (10996714)
2000
18
Shape-Set dimensionality vs structural-distance effects in a patient with category-specific visual agnosia (10373285)
1999
19
The perception of spatial relations in a patient with visual form agnosia. (22448842)
1998
20
Literature update. Agnosia in Alzheimer disease. (9305505)
1997
21
Object recognition difficulty in visual apperceptive agnosia. (9126398)
1997
22
What is it like to be a patient with apperceptive agnosia? (9262411)
1997
23
Ettlinger revisited: the relation between agnosia and sensory impairment. (7897420)
1995
24
Verbal auditory agnosia with focal EEG abnormality: an unusual case of a child presenting to an ENT surgeon with "deafness". (7798001)
1995
25
T cells. Immunological agnosia. (8483494)
1993
26
Preserved visual imagery and categorization in a case of associative visual agnosia. (23967888)
1992
27
Rediscovering tactile agnosia. (1994134)
1991
28
Prosopagnosia and agnosia for noncanonical views. An autopsied case. (3208058)
1988
29
Verbal auditory agnosia in children. (3229568)
1988
30
Loss of topographic familiarity. An environmental agnosia. (3947250)
1986
31
Pantomime agnosia. (3701356)
1986
32
Multimodal agnosia after unilateral left hemisphere lesion. (3703298)
1986
33
Mini-object test: a new brief clinical assessment for aphasia-apraxia-agnosia. (6823578)
1983
34
Clinical and audiological findings in a case of auditory agnosia. (6176690)
1982
35
On the mechanism underlying facial-affective agnosia in senile demented patients. (7319707)
1981
36
Middle components of the auditory evoked response in bilateral temporal lobe lesions. Report on a patient with auditory agnosia. (7444333)
1980
37
Prosopo-affective agnosia as a symptom of cerebral organic disease. (429743)
1979
38
Visual agnosia: the dual deficit of perception and recognition. (540512)
1979
39
Prosopagnosia and visual object agnosia: a behavioral study. (656903)
1978
40
Pure word deafness. (Auditory verbal agnosia). (849705)
1977
41
Generalized auditory agnosia: the first phase of treatment. (5027354)
1972
42
A case study of auditory agnosia: linguistic and non-linguistic processing. (4671674)
1972
43
Visual agnosia: a single case report. (5136186)
1971
44
Right-sided unilateral visual spatial agnosia, asomatognosia and anosognosia with left hemisphere lesions. (5806126)
1969
45
Clinical aspects of visual agnosia. (5629128)
1967
46
A study of finger agnosia. (14456198)
1962
47
Visual agnosia and loss of recall; report of case. (13149986)
1954
48
Visual agnosia and alternating dominance; analysis of a case. (13109456)
1953
49
Visual agnosia for animate objects. (13085184)
1953
50
Pure visual verbal agnosia with spatial disorientation; report of a case. (18910047)
1948

Genetic Variations for Agnosia

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Expression for genes affiliated with Agnosia

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1BioGPS, 15Gene Expression Omnibus DataSets
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Expression patterns in normal tissues for genes affiliated with Agnosia

Search GEO for disease gene expression data for Agnosia.

Pathways for genes affiliated with Agnosia

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12EMD Millipore, 37NCBI BioSystems Database, 53Reactome, 29KEGG
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Compounds for genes affiliated with Agnosia

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59Tocris Bioscience, 28IUPHAR, 44Novoseek, 11DrugBank, 49PharmGKB, 24HMDB
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Compounds related to Agnosia according to GeneCards/GeneDecks:

(show all 21)
idCompoundScoreTop Affiliating Genes
1ufp-10159 2811.6OPRL1, PNOC
2ban orl 245910.6OPRL1, PNOC
3npff4410.6PDYN, NPFF, PNOC
4damgo44 59 2812.6PNOC, OPRL1, PDYN
5etorphine44 28 1112.6PDYN, OPRL1, PNOC
6nociceptin5910.6OPRL1, PNOC
7jtc 8015910.6OPRL1, PNOC
8buprenorphine44 28 1112.6PDYN, OPRL1, PNOC
9(+-)-j 1133975910.6OPRL1, PNOC
10tetrapeptide4410.6CCKAR, NPFF, OPRL1, PNOC
11naltrindole44 2811.5NPFF, PNOC
12opiate4410.5PNOC, OPRL1, NPFF, PDYN
13nalbzoh4410.5OPRL1, PNOC
14morphine44 49 28 1113.5PNOC, OPRL1, NPFF, PDYN, CCKAR
15norbinaltorphimine4410.5PNOC, PDYN
16[3h]diprenorphine4410.5PNOC, PDYN
17atropine44 28 1112.4CCKAR, PDYN, PNOC
18naltrexone44 49 28 1113.4PNOC, OPRL1
19dpdpe28 44 5912.3PNOC, PDYN
20cyclic amp44 2411.1CCKAR, NPVF, NPFF, OPRL1, PNOC
21cocaine44 1111.0PNOC, PDYN, CCKAR

GO Terms for genes affiliated with Agnosia

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16Gene Ontology
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Biological processes related to Agnosia according to GeneCards/GeneDecks:

idNameGO IDScoreTop Affiliating Genes
1elevation of cytosolic calcium ion concentrationGO:00720410.3OPRL1, NPFF, CCKAR
2neuropeptide signaling pathwayGO:00721810.1PNOC, NPFF, NPVF, PDYN
3sensory perceptionGO:00760010.1PNOC, OPRL1

Molecular functions related to Agnosia according to GeneCards/GeneDecks:

idNameGO IDScoreTop Affiliating Genes
1neuropeptide hormone activityGO:00518410.3PNOC, NPFF
2opioid peptide activityGO:00151510.0PNOC, PDYN

Products for genes affiliated with Agnosia

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Sources for Agnosia

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3CDC
13ExPASy
14FMA
22GTR
23HGMD
24HMDB
25ICD10
26ICD10 via Orphanet
27ICD9CM
28IUPHAR
29KEGG
34MeSH
35MESH via Orphanet
36MGI
39NCIt
40NDF-RT
43NINDS
44Novoseek
46OMIM
47OMIM via Orphanet
50PubMed
51QIAGEN
57SNOMED-CT via Orphanet
60UMLS
61UMLS via Orphanet