MCID: AGN002
MIFTS: 57

Agnosia malady

Categories: Rare diseases, Mental diseases, Eye diseases

Aliases & Classifications for Agnosia

Aliases & Descriptions for Agnosia:

Name: Agnosia 12 50 51 29 42 14 69
Primary Visual Agnosia 50 69
Dyspraxia 12 51
Apraxias 42 69
Monomodal Visual Amnesia 50
Dyspraxia Syndrome 12
Visual Amnesia 50
Alexia 69

Classifications:



Summaries for Agnosia

NIH Rare Diseases : 50 agnosia is characterized by an inability to recognize and identify objects and/or persons. symptoms may vary, according to the area of the brain that is affected. it can be limited to one sensory modality such as vision or hearing; for example, a person may have difficulty in recognizing an object as a cup or identifying a sound as a cough. agnosia can result from strokes, traumatic brain injury, dementia, a tumor, developmental disorders, overexposure to environmental toxins (e.g., carbon monoxide poisoning), or other neurological conditions. visual agnosia may also occur in association with other underlying disorders. people with agnosia may retain their cognitive abilities in other areas. treatment of primary agnosia is symptomatic and supportive; when it is caused by an underlying disorder, treatment of the disorder may reduce symptoms and help prevent further brain damage. last updated: 4/22/2011

MalaCards based summary : Agnosia, also known as primary visual agnosia, is related to cervicitis and simultanagnosia, and has symptoms including cachexia, cyanosis and dyspnea. An important gene associated with Agnosia is TRPV1 (Transient Receptor Potential Cation Channel Subfamily V Member 1), and among its related pathways/superpathways are Signaling by GPCR and Peptide ligand-binding receptors. The drugs Oxytocin and Oxytocics have been mentioned in the context of this disorder. Affiliated tissues include brain, parietal lobe and eye, and related phenotypes are behavior/neurological and homeostasis/metabolism

NINDS : 51 Agnosia is a rare disorder characterized by an inability to recognize and identify objects or persons. People with agnosia may have difficulty recognizing the geometric features of an object or face or may be able to perceive the geometric features but not know what the object is used for or whether a face is familiar or not. Agnosia can be limited to one sensory modality such as vision or hearing. For example, a person may have difficulty in recognizing an object as a cup or identifying a sound as a cough. Agnosia can result from strokes, dementia, developmental disorders, or other neurological conditions. It typically results from damage to specific brain areas in the occipital or parietal lobes of the brain. People with agnosia may retain their cognitive abilities in other areas.

Disease Ontology : 12 A communication disorder that is a loss of ability to recognize objects, persons, sounds, shapes, or smells while the specific sense is not defective nor is there any significant memory loss.

Wikipedia : 71 Agnosia is the inability to process sensory information. Often there is a loss of ability to recognize... more...

Related Diseases for Agnosia

Diseases in the Agnosia family:

Form Agnosia

Diseases related to Agnosia via text searches within MalaCards or GeneCards Suite gene sharing:

(show top 50) (show all 96)
id Related Disease Score Top Affiliating Genes
1 cervicitis 29.7 CCK OPRK1 OPRM1
2 simultanagnosia 29.4 AP1M2 AP2M1 CCK CNR1 HTR7 LIPN
3 visual agnosia 12.2
4 auditory agnosia 12.2
5 apperceptive agnosia 12.2
6 rolandic epilepsy, mental retardation, and speech dyspraxia 12.1
7 verbal auditory agnosia 12.1
8 finger agnosia 12.1
9 developmental dyspraxia 12.1
10 integrative agnosia 12.1
11 tactile agnosia 12.1
12 form agnosia 12.1
13 topographical agnosia 12.1
14 social emotional agnosia 12.1
15 associative agnosia 12.1
16 pain agnosia 12.0
17 mirror agnosia 12.0
18 visual verbal agnosia 12.0
19 semantic agnosia 12.0
20 time agnosia 11.9
21 color agnosia 11.9
22 rolandic epilepsy-speech dyspraxia syndrome 11.8
23 astereognosia 11.4
24 autotopagnosia 11.3
25 cortical deafness 11.2
26 prosopagnosia 11.2
27 gerstmann syndrome 11.1
28 apraxia 11.1
29 alexia 11.1
30 alexithymia 11.0
31 amusia 11.0
32 anosognosia 11.0
33 agraphia 11.0
34 phonagnosia 11.0
35 achromatopsia 11.0
36 akinetopsia 10.6
37 kluver-bucy syndrome 10.6
38 nominal aphasia 10.6
39 klüver-bucy syndrome 10.6
40 aphasia 10.2
41 acute contagious conjunctivitis 10.2 CCK OPRM1 PDYN
42 testicular leydig cell tumor 10.2 OPRM1 TAC1 TRPV1
43 autoimmune progesterone dermatitis 10.2 CNR1 TRPV1
44 scleral staphyloma 10.2 CCK HTR7 TRPV1
45 peripheral vertigo 10.2 OPRK1 OPRM1 PNOC
46 siberian tick typhus 10.2 CNR1 HTR7 PDYN
47 suppurative periapical periodontitis 10.2 OPRK1 OPRM1 PDYN POMC
48 astroblastoma 10.2 LIPN OXT POMC
49 transmitted_by 10.2 OPRK1 OPRM1 PDYN POMC
50 deafness, autosomal recessive 20 10.2 CCK HTR7 TAC1 TRPV1

Graphical network of the top 20 diseases related to Agnosia:



Diseases related to Agnosia

Symptoms & Phenotypes for Agnosia

UMLS symptoms related to Agnosia:


cachexia, cyanosis, dyspnea, edema, fever, headache, icterus, seizures, signs and symptoms, signs and symptoms, digestive, syncope, vertigo, reduced consciousness/confusion, visual agnosia, other symbolic dysfunction, hot flushes, scanning speech, muscle rigidity, torticollis, clumsiness, abnormality of extrapyramidal motor function, symptoms

MGI Mouse Phenotypes related to Agnosia:

44
id Description MGI Source Accession Score Top Affiliating Genes
1 behavior/neurological MP:0005386 10.03 CCK CNR1 HTR7 OPRK1 OPRL1 OPRM1
2 homeostasis/metabolism MP:0005376 9.93 AP1M2 CCK CNR1 HTR7 LIPN OPRK1
3 adipose tissue MP:0005375 9.8 CNR1 OPRM1 OXT PDYN POMC TRPV1
4 integument MP:0010771 9.7 PDYN PNOC POMC TAC1 TRPV1 CNR1
5 nervous system MP:0003631 9.32 CCK CNR1 HTR7 OPRK1 OPRL1 OPRM1

Drugs & Therapeutics for Agnosia

Drugs for Agnosia (from DrugBank, HMDB, Dgidb, PharmGKB, IUPHAR, NovoSeek, BitterDB):


id Name Status Phase Clinical Trials Cas Number PubChem Id
1
Oxytocin Approved, Vet_approved Early Phase 1 50-56-6 439302 53477758
2 Oxytocics Early Phase 1

Interventional clinical trials:


id Name Status NCT ID Phase
1 Perception and Multisensory Integration in Neurological Patients Using fMRI Unknown status NCT01469858
2 Orientation Agnosia: Clinical and Anatomical Study Completed NCT01304576
3 Functional Magnetic Resonance Imaging (fMRI) of Anosognosia in Amnestic Mild Cognitive Impairment (MCI) and Alzheimer's Disease (AD) Completed NCT00908999
4 Lack of Awareness of Symptoms (Anosognosia) in PD: An Observational Study for People With Parkinson's Recruiting NCT02561715
5 Anosognosia Evaluation After Cranocerebral Trauma Moderate to Severe Recruiting NCT02333006
6 Processing Integration in Neurological Patients Using fMRI Not yet recruiting NCT02722070
7 The Effect of Oxytocin on Face Perception Suspended NCT02091817 Early Phase 1

Search NIH Clinical Center for Agnosia

Cochrane evidence based reviews: agnosia

Genetic Tests for Agnosia

Genetic tests related to Agnosia:

id Genetic test Affiliating Genes
1 Agnosia 29

Anatomical Context for Agnosia

MalaCards organs/tissues related to Agnosia:

39
Brain, Parietal Lobe, Eye, Cortex, Temporal Lobe, T Cells, Testes

Publications for Agnosia

Articles related to Agnosia:

(show top 50) (show all 409)
id Title Authors Year
1
Landmark Agnosia: Evaluating the Definition of Landmark-based Navigation Impairment. ( 28164221 )
2017
2
Impaired peripheral reaching and on-line corrections in patient DF: Optic ataxia with visual form agnosia. ( 28532578 )
2017
3
Pearls & Oy-sters: Visual agnosia: An overlooked cortical sign. ( 27821572 )
2016
4
Agnosia for head tremor in essential tremor: prevalence and clinical correlates. ( 26877883 )
2016
5
Poster 215 Gustatory Agnosia Following Herpes Simplex Virus Encephalitis: A Case Report. ( 27672976 )
2016
6
Impaired Velocity Processing Reveals an Agnosia for Motion in Depth. ( 27677897 )
2016
7
Enhancing Diversity in Academic Neurology: From Agnosia to Action. ( 26972163 )
2016
8
Functional dissociation between action and perception of object shape in developmental visual object agnosia. ( 26827163 )
2016
9
Hurt but still alive: Residual activity in the parahippocampal cortex conditions the recognition of familiar places in a patient with topographic agnosia. ( 26909331 )
2016
10
Emotional quotient in frontotemporal dementia vs. Alzheimer's disease: the role of socioemotional agnosia. ( 27903133 )
2016
11
What's in the name 'alexithymia'? A commentary on "Affective agnosia: Expansion of the alexithymia construct and a new opportunity to integrate and extend Freud's legacy.". ( 27235080 )
2016
12
Functional Mapping of the Human Auditory Cortex: fMRI Investigation of a Patient with Auditory Agnosia from Trauma to the Inferior Colliculus. ( 26413744 )
2015
13
Real-time vision, tactile cues, and visual form agnosia: removing haptic feedback from a "natural" grasping task induces pantomime-like grasps. ( 25999834 )
2015
14
Reprint of: Visual processing of words in a patient with visual form agnosia: A behavioural and fMRI study. ( 26475097 )
2015
15
Emergence delirium with transient associative agnosia and expressive aphasia reversed by flumazenil in a pediatric patient. ( 26035220 )
2015
16
Affective agnosia: Expansion of the alexithymia construct and a new opportunity to integrate and extend Freud's legacy. ( 26054794 )
2015
17
Auditory agnosia. ( 25726291 )
2015
18
Which visual functions depend on intermediate visual regions? Insights from a case of developmental visual form agnosia. ( 26209358 )
2015
19
Visual processing of words in a patient with visual form agnosia: a behavioural and fMRI study. ( 25461705 )
2015
20
Simultanagnosia and scene agnosia induced by right posterior cerebral artery infarction: a case report. ( 26369377 )
2015
21
Intact implicit representation of object 3D structure in object agnosia. ( 26326787 )
2015
22
Pure word deafness with auditory object agnosia after bilateral lesion of the superior temporal sulcus. ( 26343343 )
2015
23
Tactile Toe Agnosia and Percept of a "Missing Toe" in Healthy Humans. ( 26562866 )
2015
24
Visual agnosia. ( 26358494 )
2015
25
Training-induced recovery of low-level vision followed by mid-level perceptual improvements in developmental object and face agnosia. ( 24698161 )
2014
26
Mirror image agnosia. ( 25336773 )
2014
27
Neurodegeneration and mirror image agnosia. ( 25317393 )
2014
28
Agnosia for mirror stimuli: a new case report with a small parietal lesion. ( 25037846 )
2014
29
Pure associative tactile agnosia for the left hand: clinical and anatomo-functional correlations. ( 25046697 )
2014
30
Patient DF's visual brain in action: Visual feedforward control in visual form agnosia. ( 25199609 )
2014
31
When apperceptive agnosia is explained by a deficit of primary visual processing. ( 24607265 )
2014
32
Delayed action does not always require the ventral stream: a study on a patient with visual form agnosia. ( 24657477 )
2014
33
Episodic epileptic verbal auditory agnosia in Landau Kleffner syndrome treated with combination diazepam and corticosteroids. ( 24453158 )
2014
34
Visual object agnosia is associated with a breakdown of object-selective responses in the lateral occipital cortex. ( 24863251 )
2014
35
Psychosis, agnosia, and confabulation: an alternative two-factor account. ( 24328860 )
2014
36
Selective preservation of the beat in apperceptive music agnosia: a case study. ( 24561388 )
2014
37
The mitochondrial DNA 10197 Ga88>a88A mutation causes MELAS/Leigh overlap syndrome presenting with acute auditory agnosia. ( 24708134 )
2014
38
Auditory agnosia as a clinical symptom of childhood adrenoleukodystrophy. ( 25544384 )
2014
39
Agnosia in Canon: a Historical Issue. ( 26110161 )
2014
40
Auditory agnosia in a patient with nephrotic syndrome. ( 23322309 )
2013
41
Agnosia for accents in primary progressive aphasia. ( 23721780 )
2013
42
Making memories: the development of long-term visual knowledge in children with visual agnosia. ( 24319599 )
2013
43
Corticobasal syndrome presenting with partial Gerstmann's syndrome and digit agnosia. ( 23686076 )
2013
44
Configural Gestalts remain nothing more than the sum of their parts in visual agnosia. ( 25165506 )
2013
45
Acquired auditory agnosia in childhood and normal sleep electroencephalography subsequently diagnosed as Landau-Kleffner syndrome: a report of three cases. ( 23121226 )
2013
46
Clinical presentation of left angular gyrus ischaemic lesion: finger agnosia, acalculia, agraphia, left-right disorientation and episodic autoscopia. ( 23813508 )
2013
47
Structural and functional changes across the visual cortex of a patient with visual form agnosia. ( 23904613 )
2013
48
Selective impairment of living things and musical instruments on a verbal 'Semantic Knowledge Questionnaire' in a case of apperceptive visual agnosia. ( 22771855 )
2012
49
A case of generalized auditory agnosia with unilateral subcortical brain lesion. ( 23342322 )
2012
50
Perception of biological motion in visual agnosia. ( 22973210 )
2012

Variations for Agnosia

Expression for Agnosia

Search GEO for disease gene expression data for Agnosia.

Pathways for Agnosia

GO Terms for Agnosia

Cellular components related to Agnosia according to GeneCards Suite gene sharing:

id Name GO ID Score Top Affiliating Genes
1 integral component of plasma membrane GO:0005887 9.91 CNR1 HTR7 OPRK1 OPRL1 OPRM1 PSENEN
2 neuron projection GO:0043005 9.78 OPRK1 OPRL1 OPRM1 TRPV1
3 axon GO:0030424 9.71 CCK CNR1 OPRM1 TAC1
4 neuronal cell body GO:0043025 9.63 CCK OPRK1 PDYN PNOC TAC1 TRPV1
5 perikaryon GO:0043204 9.56 CCK NPFF OPRK1 OPRM1
6 terminal bouton GO:0043195 9.5 AP2M1 CCK OXT
7 clathrin adaptor complex GO:0030131 9.43 AP1M2 AP2M1
8 axon terminus GO:0043679 9.26 NPFF OPRK1 PDYN PNOC
9 dendrite GO:0030425 9.17 CCK NPFF OPRK1 OPRM1 PDYN PNOC
10 plasma membrane GO:0005886 10.23 AP2M1 CNR1 HTR7 OPRK1 OPRL1 OPRM1

Biological processes related to Agnosia according to GeneCards Suite gene sharing:

(show all 31)
id Name GO ID Score Top Affiliating Genes
1 positive regulation of apoptotic process GO:0043065 9.95 CCK CNR1 PSENEN TRPV1
2 chemical synaptic transmission GO:0007268 9.92 HTR7 NPFF OPRK1 OPRL1 OPRM1 PDYN
3 positive regulation of cytosolic calcium ion concentration GO:0007204 9.88 NPFF OPRL1 OXT TAC1 TRPV1
4 response to ethanol GO:0045471 9.82 CNR1 OPRK1 OPRM1
5 response to morphine GO:0043278 9.8 CNR1 NPFF OPRK1 OPRM1 TAC1
6 excitatory postsynaptic potential GO:0060079 9.78 NPFF OPRM1 TRPV1
7 eating behavior GO:0042755 9.77 CCK OPRK1 OPRL1 OPRM1 OXT
8 adenylate cyclase-inhibiting G-protein coupled receptor signaling pathway GO:0007193 9.75 OPRK1 OPRL1 OPRM1
9 G-protein coupled receptor signaling pathway, coupled to cyclic nucleotide second messenger GO:0007187 9.74 CNR1 HTR7 OPRM1
10 negative regulation of blood pressure GO:0045776 9.73 CNR1 OPRL1 OXT
11 response to cocaine GO:0042220 9.73 CNR1 OPRK1 OPRM1 OXT
12 sensory perception of pain GO:0019233 9.73 CNR1 OPRK1 OPRL1 OPRM1 TAC1 TRPV1
13 positive regulation of blood pressure GO:0045777 9.69 CNR1 NPFF OXT
14 estrous cycle GO:0044849 9.67 OPRK1 OPRL1 OPRM1
15 response to food GO:0032094 9.65 OPRM1 OXT
16 response to pain GO:0048265 9.64 TAC1 TRPV1
17 negative regulation of cAMP biosynthetic process GO:0030818 9.63 OPRL1 OPRM1
18 positive regulation of ossification GO:0045778 9.63 OXT TAC1
19 opioid receptor signaling pathway GO:0038003 9.63 OPRK1 OPRL1 OPRM1
20 maternal behavior GO:0042711 9.62 OPRK1 OXT
21 positive regulation of renal sodium excretion GO:0035815 9.62 OXT TAC1
22 behavior GO:0007610 9.61 OPRK1 OPRL1
23 negative regulation of heart rate GO:0010459 9.6 NPFF TAC1
24 negative regulation of appetite GO:0032099 9.59 CCK NPFF
25 acute inflammatory response to antigenic stimulus GO:0002438 9.58 NPFF OPRM1
26 sensory perception GO:0007600 9.55 OPRK1 OPRL1 OPRM1 PDYN PNOC
27 adenylate cyclase-inhibiting opioid receptor signaling pathway GO:0031635 9.54 OPRK1 OPRM1
28 positive regulation of gastric acid secretion GO:0060454 9.52 OPRL1 TRPV1
29 regulation of sensory perception of pain GO:0051930 9.43 CCK NPFF OPRK1 OPRL1 OPRM1 OXT
30 neuropeptide signaling pathway GO:0007218 9.23 NPFF OPRK1 OPRL1 OPRM1 PDYN PNOC
31 signal transduction GO:0007165 10.25 CCK CNR1 HTR7 OPRK1 OPRL1 OPRM1

Molecular functions related to Agnosia according to GeneCards Suite gene sharing:

id Name GO ID Score Top Affiliating Genes
1 hormone activity GO:0005179 9.54 CCK OXT POMC
2 neuropeptide binding GO:0042923 9.33 OPRK1 OPRL1 OPRM1
3 opioid receptor binding GO:0031628 9.32 PDYN PNOC
4 opioid peptide activity GO:0001515 9.26 PDYN PNOC
5 opioid receptor activity GO:0004985 9.13 OPRK1 OPRL1 OPRM1
6 neuropeptide hormone activity GO:0005184 9.02 CCK NPFF OXT PDYN PNOC

Sources for Agnosia

3 CDC
7 CNVD
9 Cosmic
10 dbSNP
11 DGIdb
16 ExPASy
18 FMA
28 GO
29 GTR
30 HGMD
31 HMDB
32 HPO
33 ICD10
34 ICD10 via Orphanet
35 ICD9CM
36 IUPHAR
37 KEGG
38 LifeMap
40 MedGen
42 MeSH
43 MESH via Orphanet
44 MGI
46 NCI
47 NCIt
48 NDF-RT
51 NINDS
52 Novoseek
54 OMIM
55 OMIM via Orphanet
59 PubMed
60 QIAGEN
65 SNOMED-CT via Orphanet
67 TGDB
68 Tocris
69 UMLS
70 UMLS via Orphanet
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