MCID: AGN002
MIFTS: 54

Agnosia malady

Categories: Rare diseases, Fetal diseases, Eye diseases

Aliases & Classifications for Agnosia

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Aliases & Descriptions for Agnosia:

Name: Agnosia 10 45 46 12 36 65
Primary Visual Agnosia 45 65
Dyspraxia 10 46
Apraxias 36 65
 
Monomodal Visual Amnesia 45
Dyspraxia Syndrome 10
Visual Amnesia 45
Alexia 65

Classifications:



External Ids:

Disease Ontology10 DOID:4090
ICD1027 R48.1, R48.2
NCIt42 C84542
UMLS65 C0001816, C0003635

Summaries for Agnosia

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NIH Rare Diseases:45 Agnosia is characterized by an inability to recognize and identify objects and/or persons. symptoms may vary, according to the area of the brain that is affected. it can be limited to one sensory modality such as vision or hearing; for example, a person may have difficulty in recognizing an object as a cup or identifying a sound as a cough. agnosia can result from strokes, traumatic brain injury, dementia, a tumor, developmental disorders, overexposure to environmental toxins (e.g., carbon monoxide poisoning), or other neurological conditions. visual agnosia may also occur in association with other underlying disorders. people with agnosia may retain their cognitive abilities in other areas. treatment of primary agnosia is symptomatic and supportive; when it is caused by an underlying disorder, treatment of the disorder may reduce symptoms and help prevent further brain damage. last updated: 4/22/2011

MalaCards based summary: Agnosia, also known as primary visual agnosia, is related to phonagnosia and visual agnosia, and has symptoms including hemiasomatognosia, altered pitch perception and autoscopy. An important gene associated with Agnosia is OPRM1 (Opioid Receptor Mu 1), and among its related pathways are Syndecan-3-mediated signaling events and Peptide ligand-binding receptors. Affiliated tissues include brain, parietal lobe and liver, and related mouse phenotypes are adipose tissue and integument.

Disease Ontology:10 A communication disorder that is a loss of ability to recognize objects, persons, sounds, shapes, or smells while the specific sense is not defective nor is there any significant memory loss.

NINDS:46 Agnosia is a rare disorder characterized by an inability to recognize and identify objects or persons. People with agnosia may have difficulty recognizing the geometric features of an object or face or may be able to perceive the geometric features but not know what the object is used for or whether a face is familiar or not. Agnosia can be limited to one sensory modality such as vision or hearing. For example, a person may have difficulty in recognizing an object as a cup or identifying a sound as a cough. Agnosia can result from strokes, dementia, developmental disorders, or other neurological conditions. It typically results from damage to specific brain areas in the occipital or parietal lobes of the brain. People with agnosia may retain their cognitive abilities in other areas.

Wikipedia:68 Agnosia is the inability to process sensory information. Often there is a loss of ability to recognize... more...

Related Diseases for Agnosia

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Diseases in the Agnosia family:

Form Agnosia

Diseases related to Agnosia via text searches within MalaCards or GeneCards Suite gene sharing:

(show top 50)    (show all 135)
idRelated DiseaseScoreTop Affiliating Genes
1phonagnosia25.2AP1M2, AP2M1, CNR1, HTR2A, HTR7, NOL3
2visual agnosia12.2
3auditory agnosia12.2
4rolandic epilepsy, mental retardation, and speech dyspraxia12.2
5developmental dyspraxia12.2
6tactile agnosia12.1
7form agnosia12.1
8topographical agnosia12.1
9apperceptive agnosia12.1
10verbal auditory agnosia12.1
11finger agnosia12.1
12associative agnosia12.1
13pain agnosia12.1
14integrative agnosia12.1
15mirror agnosia12.0
16visual verbal agnosia12.0
17semantic agnosia12.0
18social emotional agnosia12.0
19time agnosia12.0
20color agnosia11.9
21rolandic epilepsy-speech dyspraxia syndrome11.9
22childhood apraxia of speech11.6
23astereognosia11.4
24autotopagnosia11.2
25retrograde amnesia10.9HTR2A, POMC
26mesenchymal chondrosarcoma10.9PDYN, POMC
27smooth muscle tumor10.9HTR2A, POMC
28histiocytosis10.8HTR2A, POMC
29tic disorder10.8CNR1, HTR2A
30phimosis10.8POMC, TRPV1
31buphthalmos10.8OPRM1, PDYN
32autoimmune enteropathy10.8CNR1, TRPV1
33xerophthalmia10.8HTR2A, HTR7
34liver leiomyoma10.8HTR2A, HTR7
35hemangioma of spleen10.8OPRM1, PDYN, POMC
36spastic paraplegia 46, autosomal recessive10.8APTX, SETX
37muscular dystrophy, limb-girdle, type 2c10.7APTX, SETX
38prosopagnosia10.7
39olfactory nerve disease10.7PDYN, POMC
40lobomycosis10.7PDYN, PSENEN
41hematocele of tunica vaginalis testis10.7HTR2A, OXT
42prostatocystitis10.7HTR2A, OXT
43spinocerebellar ataxia, autosomal recessive 1210.7NOL3, PNOC
44ego-dystonic sexual orientation10.7HTR2A, OXT
45parasitic protozoa infectious disease10.7APTX, PDYN, SETX
46testicular brenner tumor10.7HTR2A, OPRM1, TRPV1
47drug dependence10.7CNR1, OPRM1, POMC
48apraxia10.7
49alexia10.7
50nocardiosis10.7HTR2A, TAC1

Graphical network of the top 20 diseases related to Agnosia:



Diseases related to agnosia

Symptoms for Agnosia

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UMLS symptoms related to Agnosia:


hemiasomatognosia, altered pitch perception, autoscopy, gait dyspraxia, symptoms, amimia, hemiapraxia, cortical dysfunction nec, neurologic neglect syndrome, hot flushes, neurobehavioral manifestations, dyspraxia of arm, abnormal coordination, specific learning problem, neurological symptom/complaint other, dyslexia and other symbolic dysfunctions, not elsewhere classified, other and unspecified symbolic dysfunctions, other and unspecified lack of coordination, visual agnosia, disturbance of consciousness, extrapyramidal sign, clumsiness, vertigo, torticollis, syncope, signs and symptoms, digestive, signs and symptoms, seizures, muscle rigidity, lethargy, headache, enuresis, dyspnea, cyanosis, cachexia, alexia and agraphia present, scanning speech, hallucinations, olfactory

Drugs & Therapeutics for Agnosia

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Drugs for Agnosia (from DrugBank, HMDB, Dgidb, PharmGKB, IUPHAR, NovoSeek, BitterDB):

idNameStatusPhaseClinical TrialsCas NumberPubChem Id
1
OxytocinapprovedPhase 036650-56-6439302, 53477758
Synonyms:
(2S)-1-[(4R,7S,10S,13S,16S,19R)-19-amino-7-(2-amino-2-oxoethyl)-10-(3-amino-3-oxopropyl)-13-[(2S)-butan-2-yl]-16-[(4-hydroxyphenyl)methyl]-6,9,12,15,18-pentaoxo-1,2-dithia-5,8,11,14,17-pentazacycloicosane-4-carbonyl]-N-[(2S)-1-[(2-amino-2-oxoethyl)amino]-4-methyl-1-oxopentan-2-yl]pyrrolidine-2-carboxamide
(Arg8)-Vasopressin
(Arg8)-Vasotocin
1-({(4R,7S,10S,13S,16S,19R)-19-amino-7-(2-amino-2-oxoethyl)-10-(3-amino-3-oxopropyl)-16-(4-hydroxybenzyl)-13-[(1S)-1-methylpropyl]-6,9,12,15,18-pentaoxo-1,2-dithia-5,8,11,14,17-pentaazacycloicosan-4-yl}carbonyl)-L-prolyl-L-leucylglycinamide
50-56-6
AC1L9735
Argipressin
Argpressin Acetate
BCBcMAP01_000094
Biotinyl-(Arg8)-Vasopressin
C00746
CHEBI:492195
CHEBI:7872
CHEMBL395429
CID439302
Cys-Tyr-Ile-Gln-Asn-Cys-Pro-Arg-Gly-NH2
Cys-Tyr-Ile-Gln-Asn-Cys-Pro-Leu-Gly-NH2
Cys-Tyr-Ile-Thr-Asn-Cys-Gly-Leu-Gly-NH2
Cys-Tyr-Phe-Gln-Asn-Cys-Pro-Arg-Gly-NH2
Cys-Tyr-Phe-Gln-Asn-Cys-Pro-Lys-Gly-NH2
D00089
Disulfide bridge Cys1-Cys6
Gly-Leu-Pro-c
HS-2021
L-Cysteinyl-L-tyrosyl-L-isoleucyl-L-glutaminyl-L-asparaginyl-L-cysteinyl-L-prolyl-L-leucylglycinamide cyclic(1-6)-disulfide
MolPort-003-938-941
 
NCGC00167132-01
O3251_SIGMA
O4375_SIGMA
OXT
OXYTOCIN
Ocytocin
Oxitocina
Oxytocic hormone
Oxytocin
Oxytocin (JP15/USP/INN)
Oxytocin (TN)
Oxytocin 10 Usp Units In Dextrose 5%
Oxytocin 20 Usp Units In Dextrose 5%
Oxytocin 5 Usp Units In Dextrose 5%
Oxytocin Acetate
Oxytocin injection
Oxytocine
Oxytocinum
Pitocin
Pitocin (TN)
SID29217903
SID50111741
Syntocinon
Syntocinon (TN)
TI-001
alpha-Hypophamine
nchembio.184-comp2

Interventional clinical trials:

idNameStatusNCT IDPhase
1Orientation Agnosia: Clinical and Anatomical StudyCompletedNCT01304576
2Functional Magnetic Resonance Imaging (fMRI) of Anosognosia in Amnestic Mild Cognitive Impairment (MCI) and Alzheimer's Disease (AD)CompletedNCT00908999
3Lack of Awareness of Symptoms (Anosognosia) in PD: An Observational Study for People With Parkinson'sRecruitingNCT02561715
4The Effect of Oxytocin on Face PerceptionSuspendedNCT02091817Phase 0

Search NIH Clinical Center for Agnosia


Cochrane evidence based reviews: agnosia

Genetic Tests for Agnosia

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Anatomical Context for Agnosia

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MalaCards organs/tissues related to Agnosia:

33
Brain, Parietal lobe, Liver, Heart, Eye, Prostate, Breast

Animal Models for Agnosia or affiliated genes

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MGI Mouse Phenotypes related to Agnosia:

38
idDescriptionMGI Source AccessionScoreTop Affiliating Genes
1MP:00053759.5CNR1, OPRM1, OXT, PDYN, POMC, TRPV1
2MP:00107718.5CNR1, HTR7, OPRL1, OPRM1, OXT, PDYN
3MP:00053868.0CNR1, HTR2A, HTR7, OPRL1, OPRM1, OXT

Publications for Agnosia

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Articles related to Agnosia:

(show top 50)    (show all 404)
idTitleAuthorsYear
1
Hurt but still alive: Residual activity in the parahippocampal cortex conditions the recognition of familiar places in a patient with topographic agnosia. (26909331)
2016
2
Agnosia for head tremor in essential tremor: prevalence and clinical correlates. (26877883)
2016
3
Affective agnosia: Expansion of the alexithymia construct and a new opportunity to integrate and extend Freud's legacy. (26054794)
2015
4
Simultanagnosia and scene agnosia induced by right posterior cerebral artery infarction: a case report. (26369377)
2015
5
Patient DF's visual brain in action: Visual feedforward control in visual form agnosia. (25199609)
2014
6
Corticobasal syndrome presenting with partial Gerstmann's syndrome and digit agnosia. (23686076)
2013
7
Impaired integration of emotional faces and affective body context in a rare case of developmental visual agnosia. (21482423)
2012
8
Eye movements during object recognition in visual agnosia. (22627025)
2012
9
Modeling eye movements in visual agnosia with a saliency map approach: bottom-up guidance or top-down strategy? (21316191)
2011
10
The functional neuroanatomy of object agnosia: a case study. (21745637)
2011
11
A case of complex regional pain syndrome with agnosia for object orientation. (21450404)
2011
12
Associative visual agnosia: a case study. (18413915)
2008
13
Preserved implicit form perception and orientation adaptation in visual form agnosia. (16620887)
2006
14
Covert colour processing in colour agnosia. (16420956)
2006
15
No double-dissociation between optic ataxia and visual agnosia: multiple sub-streams for multiple visuo-manual integrations. (16753188)
2006
16
Agnosia for object orientation: naming and mental rotation evidence. (12221142)
2002
17
Hierarchical versus parallel processing in tactile object recognition: a behavioural-neuroanatomical study of aperceptive tactile agnosia. (12390978)
2002
18
The role of premorbid expertise on object identification in a patient with category-specific visual agnosia. (20957546)
2002
19
Animals and artifacts may not be treated equally: differentiating strong and weak forms of category-specific visual agnosia. (11237370)
2001
20
Visual agnosia after treatment of a posterior fossa ependymoma in a 16-month-old girl. (11575616)
2001
21
The influence of premorbid language skills and behavior on language recovery in children with verbal auditory agnosia. (10641609)
2000
22
Superior single dimension relative to "exclusive or" categorization performance by a patient with category-specific visual agnosia: empirical data and an ALCOVE simulation. (10857684)
2000
23
Perception of dynamic acoustic patterns by an individual with unilateral verbal auditory agnosia. (10860565)
2000
24
Impaired face and word recognition without object agnosia. (9920470)
1999
25
The perception of spatial relations in a patient with visual form agnosia. (22448842)
1998
26
Grasping spatial relationships: failure to demonstrate allocentric visual coding in a patient with visual form agnosia. (9787053)
1998
27
Separate visual pathways for perception of actions and objects: evidence from a case of apperceptive agnosia. (9728957)
1998
28
Finger agnosia: fiction or reality? (8179491)
1994
29
Visual agnosia: a case of reduced attentional "spotlight"? (1478087)
1992
30
The role of sensorimotor experience in object recognition. A case of multimodal agnosia. (1782531)
1991
31
Auditory agnosia with relative sparing of speech perception. (2707006)
1989
32
Loss of topographic familiarity. An environmental agnosia. (3947250)
1986
33
Visual agnosia without alexia. (6539870)
1984
34
Prosopagnosia and visual object agnosia: a behavioral study. (656903)
1978
35
Distinctive features of unilateral spatial agnosia in right and left brain-damaged patients. (615703)
1977
36
Generalized auditory agnosia: the first phase of treatment. (5027354)
1972
37
Visual agnosia. (4577659)
1972
38
Visual agnosia. (4671311)
1972
39
Right-sided unilateral visual spatial agnosia, asomatognosia and anosognosia with left hemisphere lesions. (5806126)
1969
40
The child who does not talk. Problems of diagnosis with special reference to children with severe auditory agnosia. (5999081)
1966
41
PURE AUDITORY AGNOSIA ASSOCIATED WITH ALTERATION OF VOICE AND PERSONAL CHARACTER. A CASE REPORT. (14332144)
1965
42
OBSERVATIONS ON COLOUR AGNOSIA. (14200783)
1964
43
Clumsy children: developmental apraxia and agnosia. (13998739)
1962
44
Sensory deprivation, sensory suppression and agnosia: notes for a neurologic theory. (13776128)
1961
45
Agnosia in animal and man. (13056106)
1953
46
Visual agnosia and alternating dominance; analysis of a case. (13109456)
1953
47
Cerebral localization in aphasia and agnosia. (14770629)
1950
48
Aphasia, apraxia, and agnosia; a new classification. (21017997)
1946
49
50

Variations for Agnosia

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Expression for genes affiliated with Agnosia

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Search GEO for disease gene expression data for Agnosia.

Pathways for genes affiliated with Agnosia

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GO Terms for genes affiliated with Agnosia

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Cellular components related to Agnosia according to GeneCards Suite gene sharing:

idNameGO IDScoreTop Affiliating Genes
1clathrin adaptor complexGO:003013110.1AP1M2, AP2M1
2dendriteGO:00304259.4HTR2A, OPRM1, PDYN, PNOC, TRPV1
3cytosolGO:00058298.5HTR2A, NOL3, OPRL1, OPRM1, OXT, RPL34

Biological processes related to Agnosia according to GeneCards Suite gene sharing:

(show all 16)
idNameGO IDScoreTop Affiliating Genes
1mRNA splice site selectionGO:000637610.5NOL3, SETX
2urinary bladder smooth muscle contractionGO:001483210.5HTR2A, TRPV1
3sensory perceptionGO:000760010.4OPRL1, OPRM1
4eating behaviorGO:004275510.4OPRM1, OXT
5smooth muscle contractionGO:000693910.3HTR2A, HTR7
6positive regulation of renal sodium excretionGO:003581510.3OXT, TAC1
7positive regulation of ossificationGO:004577810.2OXT, TAC1
8cellular response to nerve growth factor stimulusGO:199009010.2TAC1, TRPV1
9regulation of sensory perception of painGO:005193010.2OPRL1, OPRM1, OXT
10positive regulation of blood pressureGO:004577710.1CNR1, OXT
11negative regulation of cAMP biosynthetic processGO:003081810.0OPRL1, OPRM1
12negative regulation of blood pressureGO:004577610.0CNR1, OPRL1, OXT
13response to cocaineGO:00422209.8CNR1, OPRM1, OXT
14memoryGO:00076139.5CNR1, HTR2A, OXT
15synaptic transmissionGO:00072689.2AP2M1, HTR2A, OPRL1, OPRM1, TAC1
16sensory perception of painGO:00192339.1CNR1, HTR2A, OPRL1, OPRM1, TAC1, TRPV1

Molecular functions related to Agnosia according to GeneCards Suite gene sharing:

idNameGO IDScoreTop Affiliating Genes
1opioid peptide activityGO:000151510.0PDYN, PNOC

Sources for Agnosia

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2CDC
14ExPASy
15FDA
16FMA
24GTR
25HGMD
26HMDB
27ICD10
28ICD10 via Orphanet
29ICD9CM
30IUPHAR
31KEGG
34MedGen
36MeSH
37MESH via Orphanet
38MGI
41NCI
42NCIt
43NDF-RT
46NINDS
47Novoseek
49OMIM
50OMIM via Orphanet
54PubMed
55QIAGEN
60SNOMED-CT via Orphanet
64Tumor Gene Family of Databases
65UMLS
66UMLS via Orphanet