MCID: AGN002
MIFTS: 57

Agnosia malady

Categories: Rare diseases, Mental diseases, Eye diseases

Aliases & Classifications for Agnosia

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Aliases & Descriptions for Agnosia:

Name: Agnosia 11 48 49 27 39 13 68
Primary Visual Agnosia 48 68
Dyspraxia 11 49
Apraxias 39 68
 
Monomodal Visual Amnesia 48
Dyspraxia Syndrome 11
Visual Amnesia 48
Alexia 68

Classifications:



Summaries for Agnosia

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NIH Rare Diseases:48 Agnosia is characterized by an inability to recognize and identify objects and/or persons. symptoms may vary, according to the area of the brain that is affected. it can be limited to one sensory modality such as vision or hearing; for example, a person may have difficulty in recognizing an object as a cup or identifying a sound as a cough. agnosia can result from strokes, traumatic brain injury, dementia, a tumor, developmental disorders, overexposure to environmental toxins (e.g., carbon monoxide poisoning), or other neurological conditions. visual agnosia may also occur in association with other underlying disorders. people with agnosia may retain their cognitive abilities in other areas. treatment of primary agnosia is symptomatic and supportive; when it is caused by an underlying disorder, treatment of the disorder may reduce symptoms and help prevent further brain damage. last updated: 4/22/2011

MalaCards based summary: Agnosia, also known as primary visual agnosia, is related to cervicitis and simultanagnosia, and has symptoms including cachexia, cachexia and cyanosis. An important gene associated with Agnosia is TRPV1 (Transient Receptor Potential Cation Channel Subfamily V Member 1), and among its related pathways are Syndecan-3-mediated signaling events and Cell-type Dependent Selectivity of CCK2R Signaling. Affiliated tissues include brain, parietal lobe and temporal lobe, and related mouse phenotypes are adipose tissue and integument.

NINDS:49 Agnosia is a rare disorder characterized by an inability to recognize and identify objects or persons. People with agnosia may have difficulty recognizing the geometric features of an object or face or may be able to perceive the geometric features but not know what the object is used for or whether a face is familiar or not. Agnosia can be limited to one sensory modality such as vision or hearing. For example, a person may have difficulty in recognizing an object as a cup or identifying a sound as a cough. Agnosia can result from strokes, dementia, developmental disorders, or other neurological conditions. It typically results from damage to specific brain areas in the occipital or parietal lobes of the brain. People with agnosia may retain their cognitive abilities in other areas.

Disease Ontology:11 A communication disorder that is a loss of ability to recognize objects, persons, sounds, shapes, or smells while the specific sense is not defective nor is there any significant memory loss.

Wikipedia:71 Agnosia is the inability to process sensory information. Often there is a loss of ability to recognize... more...

Related Diseases for Agnosia

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Diseases in the Agnosia family:

Form Agnosia

Diseases related to Agnosia via text searches within MalaCards or GeneCards Suite gene sharing:

(show top 50)    (show all 96)
idRelated DiseaseScoreTop Affiliating Genes
1cervicitis29.7CCK, OPRK1, OPRM1
2simultanagnosia29.4AP1M2, AP2M1, CCK, CNR1, HTR7, LIPN
3visual agnosia12.2
4auditory agnosia12.2
5apperceptive agnosia12.2
6rolandic epilepsy, mental retardation, and speech dyspraxia12.1
7verbal auditory agnosia12.1
8finger agnosia12.1
9developmental dyspraxia12.1
10integrative agnosia12.1
11tactile agnosia12.1
12form agnosia12.1
13topographical agnosia12.1
14social emotional agnosia12.1
15associative agnosia12.1
16pain agnosia12.0
17mirror agnosia12.0
18visual verbal agnosia12.0
19semantic agnosia12.0
20time agnosia11.9
21color agnosia11.9
22rolandic epilepsy-speech dyspraxia syndrome11.8
23astereognosia11.4
24autotopagnosia11.3
25cortical deafness11.2
26prosopagnosia11.2
27gerstmann syndrome11.1
28apraxia11.1
29alexia11.1
30alexithymia11.0
31amusia11.0
32anosognosia11.0
33agraphia11.0
34phonagnosia11.0
35achromatopsia11.0
36akinetopsia10.6
37kluver-bucy syndrome10.6
38nominal aphasia10.6
39klüver-bucy syndrome10.6
40aphasia10.2
41acute contagious conjunctivitis10.2CCK, OPRM1, PDYN
42testicular leydig cell tumor10.2OPRM1, TAC1, TRPV1
43autoimmune progesterone dermatitis10.2CNR1, TRPV1
44scleral staphyloma10.2CCK, HTR7, TRPV1
45peripheral vertigo10.2OPRK1, OPRM1, PNOC
46siberian tick typhus10.2CNR1, HTR7, PDYN
47suppurative periapical periodontitis10.2OPRK1, OPRM1, PDYN, POMC
48astroblastoma10.2LIPN, OXT, POMC
49transmitted_by10.2OPRK1, OPRM1, PDYN, POMC
50deafness, autosomal recessive 2010.2CCK, HTR7, TAC1, TRPV1

Graphical network of the top 20 diseases related to Agnosia:



Diseases related to agnosia

Symptoms & Phenotypes for Agnosia

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UMLS symptoms related to Agnosia:


cachexia, cyanosis, dyspnea, edema, fever, headache, icterus, seizures, signs and symptoms, signs and symptoms, digestive, syncope, vertigo, reduced consciousness/confusion, visual agnosia, other symbolic dysfunction, hot flushes, scanning speech, muscle rigidity, torticollis, clumsiness, abnormality of extrapyramidal motor function, symptoms

MGI Mouse Phenotypes related to Agnosia according to GeneCards Suite gene sharing:

41
idDescriptionMGI Source AccessionScoreTop Affiliating Genes
1MP:000537510.2CNR1, OPRM1, OXT, PDYN, POMC, TRPV1
2MP:00107719.0CNR1, HTR7, OPRK1, OPRL1, OPRM1, OXT
3MP:00053868.9CCK, CNR1, HTR7, OPRK1, OPRL1, OPRM1
4MP:00053768.7AP1M2, CCK, CNR1, HTR7, LIPN, OPRK1
5MP:00036318.5CCK, CNR1, HTR7, OPRK1, OPRL1, OPRM1

Drugs & Therapeutics for Agnosia

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Drugs for Agnosia (from DrugBank, HMDB, Dgidb, PharmGKB, IUPHAR, NovoSeek, BitterDB):

idNameStatusPhaseClinical TrialsCas NumberPubChem Id
1
Oxytocinapproved, vet_approvedEarly Phase 143950-56-6439302, 53477758
Synonyms:
(2S)-1-[(4R,7S,10S,13S,16S,19R)-19-amino-7-(2-amino-2-oxoethyl)-10-(3-amino-3-oxopropyl)-13-[(2S)-butan-2-yl]-16-[(4-hydroxyphenyl)methyl]-6,9,12,15,18-pentaoxo-1,2-dithia-5,8,11,14,17-pentazacycloicosane-4-carbonyl]-N-[(2S)-1-[(2-amino-2-oxoethyl)amino]-4-methyl-1-oxopentan-2-yl]pyrrolidine-2-carboxamide
(Arg8)-Vasopressin
(Arg8)-Vasotocin
1-({(4R,7S,10S,13S,16S,19R)-19-amino-7-(2-amino-2-oxoethyl)-10-(3-amino-3-oxopropyl)-16-(4-hydroxybenzyl)-13-[(1S)-1-methylpropyl]-6,9,12,15,18-pentaoxo-1,2-dithia-5,8,11,14,17-pentaazacycloicosan-4-yl}carbonyl)-L-prolyl-L-leucylglycinamide
50-56-6
AC1L9735
Argipressin
Argpressin Acetate
BCBcMAP01_000094
Biotinyl-(Arg8)-Vasopressin
C00746
CHEBI:492195
CHEBI:7872
CHEMBL395429
CID439302
Cys-Tyr-Ile-Gln-Asn-Cys-Pro-Arg-Gly-NH2
Cys-Tyr-Ile-Gln-Asn-Cys-Pro-Leu-Gly-NH2
Cys-Tyr-Ile-Thr-Asn-Cys-Gly-Leu-Gly-NH2
Cys-Tyr-Phe-Gln-Asn-Cys-Pro-Arg-Gly-NH2
Cys-Tyr-Phe-Gln-Asn-Cys-Pro-Lys-Gly-NH2
D00089
Disulfide bridge Cys1-Cys6
Gly-Leu-Pro-c
HS-2021
 
L-Cysteinyl-L-tyrosyl-L-isoleucyl-L-glutaminyl-L-asparaginyl-L-cysteinyl-L-prolyl-L-leucylglycinamide cyclic(1-6)-disulfide
MolPort-003-938-941
NCGC00167132-01
O3251_SIGMA
O4375_SIGMA
OXT
OXYTOCIN
Ocytocin
Oxitocina
Oxytocic hormone
Oxytocin (JP15/USP/INN)
Oxytocin (TN)
Oxytocin 10 Usp Units In Dextrose 5%
Oxytocin 20 Usp Units In Dextrose 5%
Oxytocin 5 Usp Units In Dextrose 5%
Oxytocin Acetate
Oxytocin injection
Oxytocine
Oxytocinum
Pitocin
Pitocin (TN)
Syntocinon
Syntocinon (TN)
TI-001
alpha-Hypophamine
nchembio.184-comp2
2OxytocicsEarly Phase 1707

Interventional clinical trials:

idNameStatusNCT IDPhase
1Perception and Multisensory Integration in Neurological Patients Using fMRIUnknown statusNCT01469858
2Orientation Agnosia: Clinical and Anatomical StudyCompletedNCT01304576
3Functional Magnetic Resonance Imaging (fMRI) of Anosognosia in Amnestic Mild Cognitive Impairment (MCI) and Alzheimer's Disease (AD)CompletedNCT00908999
4Lack of Awareness of Symptoms (Anosognosia) in PD: An Observational Study for People With Parkinson'sRecruitingNCT02561715
5Anosognosia Evaluation After Cranocerebral Trauma Moderate to SevereRecruitingNCT02333006
6Processing Integration in Neurological Patients Using fMRINot yet recruitingNCT02722070
7The Effect of Oxytocin on Face PerceptionSuspendedNCT02091817Early Phase 1

Search NIH Clinical Center for Agnosia


Cochrane evidence based reviews: apraxias

Genetic Tests for Agnosia

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Genetic tests related to Agnosia:

id Genetic test Affiliating Genes
1 Agnosia27

Anatomical Context for Agnosia

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MalaCards organs/tissues related to Agnosia:

36
Brain, Parietal lobe, Temporal lobe, Cortex, Eye, Testes, T cells

Publications for Agnosia

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Articles related to Agnosia:

(show top 50)    (show all 409)
idTitleAuthorsYear
1
Landmark Agnosia: Evaluating the Definition of Landmark-based Navigation Impairment. (28164221)
2017
2
Impaired peripheral reaching and on-line corrections in patient DF: Optic ataxia with visual form agnosia. (28532578)
2017
3
Pearls & Oy-sters: Visual agnosia: An overlooked cortical sign. (27821572)
2016
4
Agnosia for head tremor in essential tremor: prevalence and clinical correlates. (26877883)
2016
5
Poster 215 Gustatory Agnosia Following Herpes Simplex Virus Encephalitis: A Case Report. (27672976)
2016
6
Impaired Velocity Processing Reveals an Agnosia for Motion in Depth. (27677897)
2016
7
Enhancing Diversity in Academic Neurology: From Agnosia to Action. (26972163)
2016
8
Functional dissociation between action and perception of object shape in developmental visual object agnosia. (26827163)
2016
9
Hurt but still alive: Residual activity in the parahippocampal cortex conditions the recognition of familiar places in a patient with topographic agnosia. (26909331)
2016
10
Emotional quotient in frontotemporal dementia vs. Alzheimer's disease: the role of socioemotional agnosia. (27903133)
2016
11
What's in the name 'alexithymia'? A commentary on "Affective agnosia: Expansion of the alexithymia construct and a new opportunity to integrate and extend Freud's legacy.". (27235080)
2016
12
Functional Mapping of the Human Auditory Cortex: fMRI Investigation of a Patient with Auditory Agnosia from Trauma to the Inferior Colliculus. (26413744)
2015
13
Real-time vision, tactile cues, and visual form agnosia: removing haptic feedback from a "natural" grasping task induces pantomime-like grasps. (25999834)
2015
14
Reprint of: Visual processing of words in a patient with visual form agnosia: A behavioural and fMRI study. (26475097)
2015
15
Emergence delirium with transient associative agnosia and expressive aphasia reversed by flumazenil in a pediatric patient. (26035220)
2015
16
Affective agnosia: Expansion of the alexithymia construct and a new opportunity to integrate and extend Freud's legacy. (26054794)
2015
17
Auditory agnosia. (25726291)
2015
18
Which visual functions depend on intermediate visual regions? Insights from a case of developmental visual form agnosia. (26209358)
2015
19
Visual processing of words in a patient with visual form agnosia: a behavioural and fMRI study. (25461705)
2015
20
Simultanagnosia and scene agnosia induced by right posterior cerebral artery infarction: a case report. (26369377)
2015
21
Intact implicit representation of object 3D structure in object agnosia. (26326787)
2015
22
Pure word deafness with auditory object agnosia after bilateral lesion of the superior temporal sulcus. (26343343)
2015
23
Tactile Toe Agnosia and Percept of a "Missing Toe" in Healthy Humans. (26562866)
2015
24
Visual agnosia. (26358494)
2015
25
Training-induced recovery of low-level vision followed by mid-level perceptual improvements in developmental object and face agnosia. (24698161)
2014
26
Mirror image agnosia. (25336773)
2014
27
Neurodegeneration and mirror image agnosia. (25317393)
2014
28
Agnosia for mirror stimuli: a new case report with a small parietal lesion. (25037846)
2014
29
Pure associative tactile agnosia for the left hand: clinical and anatomo-functional correlations. (25046697)
2014
30
Patient DF's visual brain in action: Visual feedforward control in visual form agnosia. (25199609)
2014
31
When apperceptive agnosia is explained by a deficit of primary visual processing. (24607265)
2014
32
Delayed action does not always require the ventral stream: a study on a patient with visual form agnosia. (24657477)
2014
33
Episodic epileptic verbal auditory agnosia in Landau Kleffner syndrome treated with combination diazepam and corticosteroids. (24453158)
2014
34
Visual object agnosia is associated with a breakdown of object-selective responses in the lateral occipital cortex. (24863251)
2014
35
Psychosis, agnosia, and confabulation: an alternative two-factor account. (24328860)
2014
36
Selective preservation of the beat in apperceptive music agnosia: a case study. (24561388)
2014
37
The mitochondrial DNA 10197 Ga88>a88A mutation causes MELAS/Leigh overlap syndrome presenting with acute auditory agnosia. (24708134)
2014
38
Auditory agnosia as a clinical symptom of childhood adrenoleukodystrophy. (25544384)
2014
39
Agnosia in Canon: a Historical Issue. (26110161)
2014
40
Auditory agnosia in a patient with nephrotic syndrome. (23322309)
2013
41
Agnosia for accents in primary progressive aphasia. (23721780)
2013
42
Making memories: the development of long-term visual knowledge in children with visual agnosia. (24319599)
2013
43
Corticobasal syndrome presenting with partial Gerstmann's syndrome and digit agnosia. (23686076)
2013
44
Configural Gestalts remain nothing more than the sum of their parts in visual agnosia. (25165506)
2013
45
Acquired auditory agnosia in childhood and normal sleep electroencephalography subsequently diagnosed as Landau-Kleffner syndrome: a report of three cases. (23121226)
2013
46
Clinical presentation of left angular gyrus ischaemic lesion: finger agnosia, acalculia, agraphia, left-right disorientation and episodic autoscopia. (23813508)
2013
47
Structural and functional changes across the visual cortex of a patient with visual form agnosia. (23904613)
2013
48
Selective impairment of living things and musical instruments on a verbal 'Semantic Knowledge Questionnaire' in a case of apperceptive visual agnosia. (22771855)
2012
49
A case of generalized auditory agnosia with unilateral subcortical brain lesion. (23342322)
2012
50
Perception of biological motion in visual agnosia. (22973210)
2012

Variations for Agnosia

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Expression for genes affiliated with Agnosia

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Search GEO for disease gene expression data for Agnosia.

GO Terms for genes affiliated with Agnosia

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Cellular components related to Agnosia according to GeneCards Suite gene sharing:

idNameGO IDScoreTop Affiliating Genes
1axonGO:003042410.5CCK, CNR1, OPRM1, TAC1
2neuron projectionGO:004300510.5OPRK1, OPRL1, OPRM1, TRPV1
3clathrin adaptor complexGO:003013110.5AP1M2, AP2M1
4perikaryonGO:004320410.4CCK, NPFF, OPRK1, OPRM1
5axon terminusGO:004367910.3NPFF, OPRK1, PDYN, PNOC
6neuronal cell bodyGO:004302510.0CCK, OPRK1, PDYN, PNOC, TAC1, TRPV1
7integral component of plasma membraneGO:00058879.9CNR1, HTR7, OPRK1, OPRL1, OPRM1, PSENEN
8dendriteGO:00304259.8CCK, NPFF, OPRK1, OPRM1, PDYN, PNOC
9terminal boutonGO:00431959.6AP2M1, CCK, OXT
10plasma membraneGO:00058868.2AP2M1, CNR1, HTR7, OPRK1, OPRL1, OPRM1

Biological processes related to Agnosia according to GeneCards Suite gene sharing:

(show all 31)
idNameGO IDScoreTop Affiliating Genes
1negative regulation of cAMP biosynthetic processGO:003081810.9OPRL1, OPRM1
2positive regulation of gastric acid secretionGO:006045410.9OPRL1, TRPV1
3response to painGO:004826510.9TAC1, TRPV1
4adenylate cyclase-inhibiting opioid receptor signaling pathwayGO:003163510.8OPRK1, OPRM1
5behaviorGO:000761010.8OPRK1, OPRL1
6response to foodGO:003209410.8OPRM1, OXT
7acute inflammatory response to antigenic stimulusGO:000243810.8NPFF, OPRM1
8positive regulation of ossificationGO:004577810.8OXT, TAC1
9positive regulation of renal sodium excretionGO:003581510.8OXT, TAC1
10negative regulation of heart rateGO:001045910.8NPFF, TAC1
11negative regulation of appetiteGO:003209910.7CCK, NPFF
12maternal behaviorGO:004271110.7OPRK1, OXT
13adenylate cyclase-inhibiting G-protein coupled receptor signaling pathwayGO:000719310.7OPRK1, OPRL1, OPRM1
14G-protein coupled receptor signaling pathway, coupled to cyclic nucleotide second messengerGO:000718710.7CNR1, HTR7, OPRM1
15estrous cycleGO:004484910.7OPRK1, OPRL1, OPRM1
16opioid receptor signaling pathwayGO:003800310.6OPRK1, OPRL1, OPRM1
17excitatory postsynaptic potentialGO:006007910.6NPFF, OPRM1, TRPV1
18response to ethanolGO:004547110.6CNR1, OPRK1, OPRM1
19negative regulation of blood pressureGO:004577610.6CNR1, OPRL1, OXT
20positive regulation of blood pressureGO:004577710.5CNR1, NPFF, OXT
21positive regulation of apoptotic processGO:004306510.5CCK, CNR1, PSENEN, TRPV1
22response to cocaineGO:004222010.4CNR1, OPRK1, OPRM1, OXT
23sensory perceptionGO:000760010.2OPRK1, OPRL1, OPRM1, PDYN, PNOC
24eating behaviorGO:004275510.2CCK, OPRK1, OPRL1, OPRM1, OXT
25positive regulation of cytosolic calcium ion concentrationGO:000720410.2NPFF, OPRL1, OXT, TAC1, TRPV1
26response to morphineGO:004327810.2CNR1, NPFF, OPRK1, OPRM1, TAC1
27sensory perception of painGO:001923310.1CNR1, OPRK1, OPRL1, OPRM1, TAC1, TRPV1
28regulation of sensory perception of painGO:00519309.9CCK, NPFF, OPRK1, OPRL1, OPRM1, OXT
29neuropeptide signaling pathwayGO:00072189.6NPFF, OPRK1, OPRL1, OPRM1, PDYN, PNOC
30chemical synaptic transmissionGO:00072689.5HTR7, NPFF, OPRK1, OPRL1, OPRM1, PDYN
31signal transductionGO:00071658.3CCK, CNR1, HTR7, OPRK1, OPRL1, OPRM1

Molecular functions related to Agnosia according to GeneCards Suite gene sharing:

idNameGO IDScoreTop Affiliating Genes
1neuropeptide bindingGO:004292310.3OPRK1, OPRL1, OPRM1
2hormone activityGO:000517910.3CCK, OXT, POMC
3opioid peptide activityGO:000151510.3PDYN, PNOC
4opioid receptor bindingGO:003162810.0PDYN, PNOC
5opioid receptor activityGO:000498510.0OPRK1, OPRL1, OPRM1
6neuropeptide hormone activityGO:00051849.6CCK, NPFF, OXT, PDYN, PNOC

Sources for Agnosia

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2CDC
6CNVD
10DGIdb
15ExPASy
16FDA
17FMA
27GTR
28HGMD
29HMDB
30ICD10
31ICD10 via Orphanet
32ICD9CM
33IUPHAR
34KEGG
37MedGen
39MeSH
40MESH via Orphanet
41MGI
44NCI
45NCIt
46NDF-RT
49NINDS
50Novoseek
52OMIM
53OMIM via Orphanet
57PubMed
58QIAGEN
63SNOMED-CT via Orphanet
67Tumor Gene Family of Databases
68UMLS
69UMLS via Orphanet