MCID: AGN002
MIFTS: 50

Agnosia malady

Eye category

Summaries for Agnosia

Sources:
8Disease Ontology, 43NIH Rare Diseases, 44NINDS, 64Wikipedia, 33MalaCards
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NINDS:44 Agnosia is a rare disorder characterized by an inability to recognize and identify objects or persons. People with agnosia may have difficulty recognizing the geometric features of an object or face or may be able to perceive the geometric features but not know what the object is used for or whether a face is familiar or not. Agnosia can be limited to one sensory modality such as vision or hearing. For example, a person may have difficulty in recognizing an object as a cup or identifying a sound as a cough. Agnosia can result from strokes, dementia, developmental disorders, or other neurological conditions. It typically results from damage to specific brain areas in the occipital or parietal lobes of the brain. People with agnosia may retain their cognitive abilities in other areas.

MalaCards: Agnosia, also known as dyspraxia, is related to visual agnosia and associative agnosia. An important gene associated with Agnosia is BBS2 (Bardet-Biedl syndrome 2), and among its related pathways are Neuropeptides signaling through G-protein alpha-i & G-protein alpha-q and Class A/1 (Rhodopsin-like receptors). The compounds ufp-101 and ban orl 24 have been mentioned in the context of this disorder. Affiliated tissues include brain, cortex and t cells, and related mouse phenotype integument.

Disease Ontology:8 A communication disorder that is a loss of ability to recognize objects, persons, sounds, shapes, or smells while the specific sense is not defective nor is there any significant memory loss.

NIH Rare Diseases:43 Agnosia is characterized by an inability to recognize and identify objects and/or persons. symptoms may vary, according to the area of the brain that is affected. it can be limited to one sensory modality such as vision or hearing; for example, a person may have difficulty in recognizing an object as a cup or identifying a sound as a cough. agnosia can result from strokes, traumatic brain injury, dementia, a tumor, developmental disorders, overexposure to environmental toxins (e.g., carbon monoxide poisoning), or other neurological conditions. visual agnosia may also occur in association with other underlying disorders. people with agnosia may retain their cognitive abilities in other areas. treatment of primary agnosia is symptomatic and supportive; when it is caused by an underlying disorder, treatment of the disorder may reduce symptoms and help prevent further brain damage. last updated: 4/22/2011

Wikipedia:64 Agnosia (from ancient Greek ἀγνωσία, \"ignorance\", \"absence of knowledge\") is a loss of... more...

Aliases & Classifications for Agnosia

Sources:
8Disease Ontology, 43NIH Rare Diseases, 44NINDS, 61UMLS, 57SNOMED-CT, 35MeSH, 40NCIt, 25ICD10
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Classifications:

Malacards categories (disease lists): (See all malacards categories)
Anatomical: Eye


Aliases & Descriptions:

agnosia 8 43 44 61
dyspraxia 8 44
monomodal visual amnesia 43
primary visual agnosia 43
dyspraxia syndrome 8
visual amnesia 43


Related Diseases for Agnosia

Sources:
17GeneCards, 18GeneDecks
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Graphical network of the top 20 diseases related to Agnosia:



Diseases related to agnosia

Clinical Features for Agnosia

Drugs & Therapeutics for Agnosia

Sources:
5CenterWatch, 42NIH Clinical Center, 6ClinicalTrials
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Approved drugs:

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Drug clinical trials:

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Genetic Tests for Agnosia

Anatomical Context for Agnosia

Sources:
33MalaCards
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MalaCards organs/tissues related to Agnosia:

33
Brain, Cortex, T cells, Parietal lobe, Temporal lobe, Occipital lobe

Animal Models for Agnosia or affiliated genes

Sources:
37MGI, 28inGenious Targeting Laboratory
See all sources

MGI Mouse Phenotypes related to Agnosia:

37
idDescriptionMGI Source AccessionScoreTop Affiliating Genes
1MP:001077110.1SP6, PNOC, OPRL1, JAG2, PDYN, LSR

Publications for Agnosia

Sources:
51PubMed
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Articles related to Agnosia:

(show top 50)    (show all 372)
idTitleAuthorsYear
1
Clinical presentation of left angular gyrus ischaemic lesion: finger agnosia, acalculia, agraphia, left-right disorientation and episodic autoscopia. (23813508)
2013
2
The functional neuroanatomy of object agnosia: a case study. (21745637)
2011
3
Auditory agnosia due to long-term severe hydrocephalus caused by spina bifida - specific auditory pathway versus nonspecific auditory pathway. (21413843)
2011
4
A selective deficit in the appreciation and recognition of brightness: brightness agnosia? (19243743)
2009
5
Visual agnosia for line drawings and silhouettes without apparent impairment of real-object recognition: a case report. (19996516)
2009
6
Analysis of lesions in patients with unilateral tactile agnosia using cytoarchitectonic probabilistic maps. (18636551)
2009
7
Pleasurable emotional response to music: a case of neurodegenerative generalized auditory agnosia. (19253088)
2009
8
Fixation and saliency during search of natural scenes: the case of visual agnosia. (19428433)
2009
9
Acute auditory agnosia as the presenting hearing disorder in MELAS. (19011735)
2008
10
Exaggerated color perception in a patient with visual form agnosia. (18781440)
2007
11
Braille alexia: an apperceptive tactile agnosia? (17635985)
2007
12
Preserved implicit form perception and orientation adaptation in visual form agnosia. (16620887)
2006
13
Independent representation of parts and the relations between them: evidence from integrative agnosia. (17002529)
2006
14
Behavioral and neuroimaging evidence for a contribution of color and texture information to scene classification in a patient with visual form agnosia. (15298783)
2004
15
Evidence for perceptual deficits in associative visual (prosop)agnosia: a single-case study. (14725798)
2004
16
Clinical management of agnosia. (14872395)
2004
17
A Case Study of Visual Agnosia without Perceptual Processing or Structural Descriptions Impairment. (20957586)
2003
18
Agnosia for scenes in topographagnosia. (12757910)
2003
19
Auditory agnosia in children after herpes encephalitis. (12701747)
2003
20
Visual agnosia and prosopagnosia in childhood: a prospective case study. (12610772)
2002
21
Animals and artifacts may not be treated equally: differentiating strong and weak forms of category-specific visual agnosia. (11237370)
2001
22
C rossmodal agnosia for familiar people as a consequence of right infero polar temporal atrophy. (20945224)
2001
23
Pure tactile agnosia. (20945214)
2001
24
Superior single dimension relative to "exclusive or" categorization performance by a patient with category-specific visual agnosia: empirical data and an ALCOVE simulation. (10857684)
2000
25
The computation of occluded contours in visual agnosia: Evidence for early computation prior to shape binding and figure-ground coding. (20945203)
2000
26
A case of verbal auditory agnosia: missing the word ... missing the sound.... (10343694)
1998
27
Autism and visual agnosia in a child with right occipital lobectomy. (9771784)
1998
28
Mirror agnosia. (9178535)
1997
29
The functional anatomy of recovery from auditory agnosia. A PET study of sound categorization in a neurological patient and normal controls. (8595472)
1995
30
Dissociation of local and global processing in visual agnosia. (8160408)
1994
31
Visual agnosia: a case of reduced attentional "spotlight"? (1478087)
1992
32
Implications of olfactory agnosia for understanding sex differences in schizophrenia. (2197715)
1990
33
Auditory agnosia with relative sparing of speech perception. (2707006)
1989
34
Visual agnosia contrasted with visual-verbal disconnection. (3974844)
1985
35
Computerized axial tomography in clumsy children with developmental apraxia and agnosia. (6189411)
1983
36
Auditory agnosia. (6125975)
1982
37
On some peculiarities of the visuomotor system in visual agnosia. (514466)
1979
38
Associative visual agnosia and its related deficits: the role of the minor hemisphere in assigning meaning to visual perceptions. (846640)
1977
39
Tactile manual agnosia. (5020290)
1972
40
Associative visual agnosia. (5548450)
1971
41
Prosopagnosia with animal face agnosia. (5387907)
1969
42
Visual agnosia and asomatognosia as behaviour disorders. (5766697)
1969
43
The child who does not talk. Problems of diagnosis with special reference to children with severe auditory agnosia. (5999081)
1966
44
AUDITORY AGNOSIA WITHOUT APHASIA. (14314279)
1965
45
Visual agnosia and irreminiscence for animate objects. (13728946)
1961
46
Cerebral localization in aphasia and agnosia. (14770629)
1950
47
Visual-spatial agnosia associated with lesions of the right cerebral hemisphere. (14791786)
1950
48
Course and outcome of visual agnosia. (15402617)
1950
49
A case of auditory agnosia. (14791788)
1950
50
Unilateral auditory-spatial agnosia. (18879812)
1948

Genetic Variations for Agnosia

Expression for genes affiliated with Agnosia

Sources:
1BioGPS, 15Gene Expression Omnibus DataSets
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Expression patterns in normal tissues for genes affiliated with Agnosia

Search GEO for disease gene expression data for Agnosia.

Pathways for genes affiliated with Agnosia

Sources:
12EMD Millipore, 38NCBI BioSystems Database, 54Reactome, 30KEGG
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Compounds for genes affiliated with Agnosia

Sources:
60Tocris Bioscience, 29IUPHAR, 45Novoseek, 11DrugBank, 50PharmGKB, 24HMDB
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Compounds related to Agnosia according to GeneCards/GeneDecks:

(show all 21)
idCompoundScoreTop Affiliating Genes
1ufp-10160 2911.6OPRL1, PNOC
2ban orl 246010.6OPRL1, PNOC
3npff4510.6PDYN, NPFF, PNOC
4damgo45 60 2912.6PNOC, OPRL1, PDYN
5etorphine45 29 1112.6PDYN, OPRL1, PNOC
6nociceptin6010.6OPRL1, PNOC
7jtc 8016010.6OPRL1, PNOC
8buprenorphine45 29 1112.6PDYN, OPRL1, PNOC
9(+-)-j 1133976010.6OPRL1, PNOC
10tetrapeptide4510.6CCKAR, NPFF, OPRL1, PNOC
11naltrindole45 2911.5NPFF, PNOC
12opiate4510.5PNOC, OPRL1, NPFF, PDYN
13nalbzoh4510.5OPRL1, PNOC
14morphine45 50 29 1113.5PNOC, OPRL1, NPFF, PDYN, CCKAR
15norbinaltorphimine4510.5PNOC, PDYN
16[3h]diprenorphine4510.5PNOC, PDYN
17atropine45 29 1112.4CCKAR, PDYN, PNOC
18naltrexone45 50 29 1113.4PNOC, OPRL1
19dpdpe29 45 6012.3PNOC, PDYN
20cyclic amp45 2411.1CCKAR, NPVF, NPFF, OPRL1, PNOC
21cocaine45 1111.0PNOC, PDYN, CCKAR

GO Terms for genes affiliated with Agnosia

Sources:
16Gene Ontology
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Biological processes related to Agnosia according to GeneCards/GeneDecks:

idNameGO IDScoreTop Affiliating Genes
1elevation of cytosolic calcium ion concentrationGO:00720410.3OPRL1, NPFF, CCKAR
2neuropeptide signaling pathwayGO:00721810.1PNOC, NPFF, NPVF, PDYN
3sensory perceptionGO:00760010.1PNOC, OPRL1

Molecular functions related to Agnosia according to GeneCards/GeneDecks:

idNameGO IDScoreTop Affiliating Genes
1neuropeptide hormone activityGO:00518410.3PNOC, NPFF
2opioid peptide activityGO:00151510.0PNOC, PDYN

Products for genes affiliated with Agnosia

  • Antibodies
  • Proteins
  • Lysates
  • Antibodies

Sources for Agnosia

3CDC
13ExPASy
14FMA
22GTR
23HGMD
24HMDB
25ICD10
26ICD10 via Orphanet
27ICD9CM
29IUPHAR
30KEGG
35MeSH
36MESH via Orphanet
37MGI
40NCIt
41NDF-RT
44NINDS
45Novoseek
47OMIM
48OMIM via Orphanet
51PubMed
52QIAGEN
58SNOMED-CT via Orphanet
61UMLS
62UMLS via Orphanet