MCID: AGN002
MIFTS: 46

Agnosia malady

Rare diseases, Fetal diseases, Eye diseases categories

Aliases & Classifications for Agnosia

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Aliases & Descriptions for Agnosia:

Name: Agnosia 10 45 46 65 36
Primary Visual Agnosia 45 65
Dyspraxia 10 46
Apraxias 65 36
 
Monomodal Visual Amnesia 45
Dyspraxia Syndrome 10
Visual Amnesia 45
Alexia 65


Classifications:



Summaries for Agnosia

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NIH Rare Diseases:45 Agnosia is characterized by an inability to recognize and identify objects and/or persons. symptoms may vary, according to the area of the brain that is affected. it can be limited to one sensory modality such as vision or hearing; for example, a person may have difficulty in recognizing an object as a cup or identifying a sound as a cough. agnosia can result from strokes, traumatic brain injury, dementia, a tumor, developmental disorders, overexposure to environmental toxins (e.g., carbon monoxide poisoning), or other neurological conditions. visual agnosia may also occur in association with other underlying disorders. people with agnosia may retain their cognitive abilities in other areas. treatment of primary agnosia is symptomatic and supportive; when it is caused by an underlying disorder, treatment of the disorder may reduce symptoms and help prevent further brain damage. last updated: 4/22/2011

MalaCards based summary: Agnosia, also known as primary visual agnosia, is related to prosopagnosia and germinoma. An important gene associated with Agnosia is OPRM1 (Opioid Receptor, Mu 1), and among its related pathways are Syndecan-3-mediated signaling events and Peptide ligand-binding receptors. Affiliated tissues include brain, parietal lobe and eye, and related mouse phenotypes are adipose tissue and integument.

Disease Ontology:10 A communication disorder that is a loss of ability to recognize objects, persons, sounds, shapes, or smells while the specific sense is not defective nor is there any significant memory loss.

NINDS:46 Agnosia is a rare disorder characterized by an inability to recognize and identify objects or persons. People with agnosia may have difficulty recognizing the geometric features of an object or face or may be able to perceive the geometric features but not know what the object is used for or whether a face is familiar or not. Agnosia can be limited to one sensory modality such as vision or hearing. For example, a person may have difficulty in recognizing an object as a cup or identifying a sound as a cough. Agnosia can result from strokes, dementia, developmental disorders, or other neurological conditions. It typically results from damage to specific brain areas in the occipital or parietal lobes of the brain. People with agnosia may retain their cognitive abilities in other areas.

Wikipedia:68 Agnosia is the inability to process sensory information. Often there is a loss of ability to recognize... more...

Related Diseases for Agnosia

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Diseases in the Agnosia family:

Form Agnosia

Diseases related to Agnosia via text searches within MalaCards or GeneCards Suite gene sharing:

(show top 50)    (show all 338)
idRelated DiseaseScoreTop Affiliating Genes
1prosopagnosia31.3PDYN, POMC, PSENEN
2germinoma30.5HTR2A, POMC, TAC1
3subacute delirium30.4HTR2A, OPRM1, PDYN, POMC
4psychotic disorder30.2HTR2A, HTR7
5segmental dystonia30.1OXT, TAC1
6simultanagnosia27.9AP1M2, C12orf10, CNR1, HTR2A, HTR7, MICE
7visual agnosia11.0
8auditory agnosia10.9
9form agnosia10.8
10ataxia, early-onset, with oculomotor apraxia and hypoalbuminemia10.7
11developmental dyspraxia10.7
12apperceptive agnosia10.6
13aphasia10.6
14tactile agnosia10.6
15verbal auditory agnosia10.6
16finger agnosia10.6
17gait apraxia10.6
18apraxia10.5
19alexia10.5
20integrative agnosia10.5
21rolandic epilepsy, mental retardation, and speech dyspraxia10.5
22associative agnosia10.5
23spinocerebellar ataxia, autosomal recessive 110.5
24blepharospasm10.4
25cerebritis10.4
26mirror agnosia10.4
27ataxia-oculomotor apraxia 310.4
28oculomotor apraxia cogan type10.4
29jejunal somatostatinoma10.4HTR2A, POMC
30ataxia-oculomotor apraxia 410.3
31primary progressive apraxia of speech10.3
32galactosemia10.3
33topographical agnosia10.3
34cortical deafness10.3
35pain agnosia10.3
36visual verbal agnosia10.3
37wieacker-wolff syndrome10.3
38ethmoid sinus squamous cell carcinoma10.3CNR1, HTR2A
39myxomatous pattern testicular yolk sac tumor10.3HTR2A, POMC
40atrophic rhinitis10.3HTR2A, POMC
41opportunistic bacterial infectious disease10.3OPRM1, PDYN, POMC
42time agnosia10.3
43social emotional agnosia10.3
44phonagnosia10.3
45semantic agnosia10.3
46developmental coordination disorder10.3
47childhood apraxia of speech10.3
48mushroom workers' lung10.3POMC, TRPV1
49hematocele of tunica vaginalis testis10.3MICE, POMC
50speech disorder10.3

Graphical network of the top 20 diseases related to Agnosia:



Diseases related to agnosia

Symptoms for Agnosia

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Drugs & Therapeutics for Agnosia

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Drugs for Agnosia (from DrugBank, HMDB, Dgidb, PharmGKB, IUPHAR, NovoSeek, BitterDB):

idNameStatusPhaseClinical TrialsCas NumberPubChem Id
1
OxytocinapprovedPhase 033550-56-6439302, 53477758
Synonyms:
(2S)-1-[(4R,7S,10S,13S,16S,19R)-19-amino-7-(2-amino-2-oxoethyl)-10-(3-amino-3-oxopropyl)-13-[(2S)-butan-2-yl]-16-[(4-hydroxyphenyl)methyl]-6,9,12,15,18-pentaoxo-1,2-dithia-5,8,11,14,17-pentazacycloicosane-4-carbonyl]-N-[(2S)-1-[(2-amino-2-oxoethyl)amino]-4-methyl-1-oxopentan-2-yl]pyrrolidine-2-carboxamide
(Arg8)-Vasopressin
(Arg8)-Vasotocin
1-({(4R,7S,10S,13S,16S,19R)-19-amino-7-(2-amino-2-oxoethyl)-10-(3-amino-3-oxopropyl)-16-(4-hydroxybenzyl)-13-[(1S)-1-methylpropyl]-6,9,12,15,18-pentaoxo-1,2-dithia-5,8,11,14,17-pentaazacycloicosan-4-yl}carbonyl)-L-prolyl-L-leucylglycinamide
50-56-6
AC1L9735
Argipressin
Argpressin Acetate
BCBcMAP01_000094
Biotinyl-(Arg8)-Vasopressin
C00746
CHEBI:492195
CHEBI:7872
CHEMBL395429
CID439302
Cys-Tyr-Ile-Gln-Asn-Cys-Pro-Arg-Gly-NH2
Cys-Tyr-Ile-Gln-Asn-Cys-Pro-Leu-Gly-NH2
Cys-Tyr-Ile-Thr-Asn-Cys-Gly-Leu-Gly-NH2
Cys-Tyr-Phe-Gln-Asn-Cys-Pro-Arg-Gly-NH2
Cys-Tyr-Phe-Gln-Asn-Cys-Pro-Lys-Gly-NH2
D00089
Disulfide bridge Cys1-Cys6
Gly-Leu-Pro-c
HS-2021
L-Cysteinyl-L-tyrosyl-L-isoleucyl-L-glutaminyl-L-asparaginyl-L-cysteinyl-L-prolyl-L-leucylglycinamide cyclic(1-6)-disulfide
MolPort-003-938-941
 
NCGC00167132-01
O3251_SIGMA
O4375_SIGMA
OXT
OXYTOCIN
Ocytocin
Oxitocina
Oxytocic hormone
Oxytocin
Oxytocin (JP15/USP/INN)
Oxytocin (TN)
Oxytocin 10 Usp Units In Dextrose 5%
Oxytocin 20 Usp Units In Dextrose 5%
Oxytocin 5 Usp Units In Dextrose 5%
Oxytocin Acetate
Oxytocin injection
Oxytocine
Oxytocinum
Pitocin
Pitocin (TN)
SID29217903
SID50111741
Syntocinon
Syntocinon (TN)
TI-001
alpha-Hypophamine
nchembio.184-comp2

Interventional clinical trials:

idNameStatusNCT IDPhase
1Orientation Agnosia: Clinical and Anatomical StudyCompletedNCT01304576
2Functional Magnetic Resonance Imaging (fMRI) of Anosognosia in Amnestic Mild Cognitive Impairment (MCI) and Alzheimer's Disease (AD)CompletedNCT00908999
3Lack of Awareness of Symptoms (Anosognosia) in PD: An Observational Study for People With Parkinson'sRecruitingNCT02561715
4The Effect of Oxytocin on Face PerceptionSuspendedNCT02091817Phase 0

Search NIH Clinical Center for Agnosia


Cochrane evidence based reviews: Agnosia

Genetic Tests for Agnosia

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Anatomical Context for Agnosia

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MalaCards organs/tissues related to Agnosia:

33
Brain, Parietal lobe, Eye, Temporal lobe, Cortex, Testes, T cells

Animal Models for Agnosia or affiliated genes

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MGI Mouse Phenotypes related to Agnosia:

38
idDescriptionMGI Source AccessionScoreTop Affiliating Genes
1MP:00053759.4CNR1, OPRM1, OXT, PDYN, POMC, TRPV1
2MP:00107717.9CNR1, HTR7, OPRL1, OPRM1, OXT, PDYN
3MP:00053867.6C12orf10, CNR1, HTR2A, HTR7, OPRL1, OPRM1

Publications for Agnosia

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Articles related to Agnosia:

(show top 50)    (show all 395)
idTitleAuthorsYear
1
Affective agnosia: Expansion of the alexithymia construct and a new opportunity to integrate and extend Freud's legacy. (26054794)
2015
2
Simultanagnosia and scene agnosia induced by right posterior cerebral artery infarction: a case report. (26369377)
2015
3
Functional Mapping of the Human Auditory Cortex: fMRI Investigation of a Patient with Auditory Agnosia from Trauma to the Inferior Colliculus. (26413744)
2015
4
Patient DF's visual brain in action: Visual feedforward control in visual form agnosia. (25199609)
2014
5
Corticobasal syndrome presenting with partial Gerstmann's syndrome and digit agnosia. (23686076)
2013
6
Impaired integration of emotional faces and affective body context in a rare case of developmental visual agnosia. (21482423)
2012
7
Eye movements during object recognition in visual agnosia. (22627025)
2012
8
Modeling eye movements in visual agnosia with a saliency map approach: bottom-up guidance or top-down strategy? (21316191)
2011
9
The functional neuroanatomy of object agnosia: a case study. (21745637)
2011
10
A case of complex regional pain syndrome with agnosia for object orientation. (21450404)
2011
11
Associative visual agnosia: a case study. (18413915)
2008
12
Specular right-left disorientation, finger-agnosia, and asomatognosia in right hemisphere stroke. (17846515)
2007
13
Preserved implicit form perception and orientation adaptation in visual form agnosia. (16620887)
2006
14
Covert colour processing in colour agnosia. (16420956)
2006
15
No double-dissociation between optic ataxia and visual agnosia: multiple sub-streams for multiple visuo-manual integrations. (16753188)
2006
16
Agnosia for object orientation: naming and mental rotation evidence. (12221142)
2002
17
Hierarchical versus parallel processing in tactile object recognition: a behavioural-neuroanatomical study of aperceptive tactile agnosia. (12390978)
2002
18
The role of premorbid expertise on object identification in a patient with category-specific visual agnosia. (20957546)
2002
19
Animals and artifacts may not be treated equally: differentiating strong and weak forms of category-specific visual agnosia. (11237370)
2001
20
Visual agnosia after treatment of a posterior fossa ependymoma in a 16-month-old girl. (11575616)
2001
21
The influence of premorbid language skills and behavior on language recovery in children with verbal auditory agnosia. (10641609)
2000
22
Superior single dimension relative to "exclusive or" categorization performance by a patient with category-specific visual agnosia: empirical data and an ALCOVE simulation. (10857684)
2000
23
Perception of dynamic acoustic patterns by an individual with unilateral verbal auditory agnosia. (10860565)
2000
24
Impaired face and word recognition without object agnosia. (9920470)
1999
25
The perception of spatial relations in a patient with visual form agnosia. (22448842)
1998
26
Grasping spatial relationships: failure to demonstrate allocentric visual coding in a patient with visual form agnosia. (9787053)
1998
27
Separate visual pathways for perception of actions and objects: evidence from a case of apperceptive agnosia. (9728957)
1998
28
Finger agnosia: fiction or reality? (8179491)
1994
29
Visual agnosia: a case of reduced attentional "spotlight"? (1478087)
1992
30
The role of sensorimotor experience in object recognition. A case of multimodal agnosia. (1782531)
1991
31
Auditory agnosia with relative sparing of speech perception. (2707006)
1989
32
Loss of topographic familiarity. An environmental agnosia. (3947250)
1986
33
Visual agnosia without alexia. (6539870)
1984
34
Prosopagnosia and visual object agnosia: a behavioral study. (656903)
1978
35
Distinctive features of unilateral spatial agnosia in right and left brain-damaged patients. (615703)
1977
36
Generalized auditory agnosia: the first phase of treatment. (5027354)
1972
37
Visual agnosia. (4577659)
1972
38
Visual agnosia. (4671311)
1972
39
A case study of auditory agnosia: linguistic and non-linguistic processing. (4671674)
1972
40
Right-sided unilateral visual spatial agnosia, asomatognosia and anosognosia with left hemisphere lesions. (5806126)
1969
41
The child who does not talk. Problems of diagnosis with special reference to children with severe auditory agnosia. (5999081)
1966
42
PURE AUDITORY AGNOSIA ASSOCIATED WITH ALTERATION OF VOICE AND PERSONAL CHARACTER. A CASE REPORT. (14332144)
1965
43
OBSERVATIONS ON COLOUR AGNOSIA. (14200783)
1964
44
Clumsy children: developmental apraxia and agnosia. (13998739)
1962
45
Sensory deprivation, sensory suppression and agnosia: notes for a neurologic theory. (13776128)
1961
46
Agnosia in animal and man. (13056106)
1953
47
Visual agnosia and alternating dominance; analysis of a case. (13109456)
1953
48
Visual agnosia for animate objects. (13085184)
1953
49
Cerebral localization in aphasia and agnosia. (14770629)
1950
50
Aphasia, apraxia, and agnosia; a new classification. (21017997)
1946

Variations for Agnosia

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Expression for genes affiliated with Agnosia

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Search GEO for disease gene expression data for Agnosia.

Pathways for genes affiliated with Agnosia

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GO Terms for genes affiliated with Agnosia

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Cellular components related to Agnosia according to GeneCards Suite gene sharing:

idNameGO IDScoreTop Affiliating Genes
1axonGO:00304249.4CNR1, HTR2A, SETX, TAC1
2integral component of plasma membraneGO:00058878.6CNR1, HTR2A, HTR7, OPRL1, OPRM1, PSENEN

Biological processes related to Agnosia according to GeneCards Suite gene sharing:

(show all 18)
idNameGO IDScoreTop Affiliating Genes
1opioid receptor signaling pathwayGO:003800310.7OPRL1, OPRM1
2serotonin receptor signaling pathwayGO:000721010.6HTR2A, HTR7
3sleepGO:003043110.5HTR2A, OXT
4smooth muscle contractionGO:000693910.5HTR2A, HTR7
5sensory perceptionGO:000760010.3OPRL1, OPRM1, PNOC
6positive regulation of ossificationGO:004577810.2OXT, TAC1
7G-protein coupled receptor signaling pathway, coupled to cyclic nucleotide second messengerGO:000718710.2CNR1, HTR7, OPRM1
8negative regulation of heart rateGO:001045910.1NPFF, TAC1
9regulation of sensory perception of painGO:005193010.0NPFF, OPRL1, OXT
10memoryGO:00076139.9CNR1, HTR2A, OXT
11positive regulation of renal sodium excretionGO:00358159.9OXT, TAC1
12positive regulation of blood pressureGO:00457779.8CNR1, NPFF, OXT
13negative regulation of blood pressureGO:00457769.6CNR1, OPRL1, OXT
14sensory perception of painGO:00192339.5CNR1, HTR2A, OPRL1, OPRM1, TAC1
15response to morphineGO:00432789.4CNR1, NPFF, TAC1
16positive regulation of cytosolic calcium ion concentrationGO:00072049.0HTR2A, NPFF, OPRL1, OPRM1, OXT, TAC1
17neuropeptide signaling pathwayGO:00072188.7NPFF, OPRL1, OPRM1, PDYN, PNOC, POMC
18synaptic transmissionGO:00072688.2HTR2A, HTR7, NPFF, OPRL1, OPRM1, PDYN

Molecular functions related to Agnosia according to GeneCards Suite gene sharing:

idNameGO IDScoreTop Affiliating Genes
1serotonin receptor activityGO:000499310.2HTR2A, HTR7
2G-protein alpha-subunit bindingGO:000196510.1HTR2A, OPRM1
3opioid peptide activityGO:000151510.0PDYN, PNOC
4neuropeptide bindingGO:00429239.8OPRL1, OPRM1

Sources for Agnosia

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2CDC
14ExPASy
15FDA
16FMA
24GTR
25HGMD
26HMDB
27ICD10
28ICD10 via Orphanet
29ICD9CM
30IUPHAR
31KEGG
34MedGen
36MeSH
37MESH via Orphanet
38MGI
41NCI
42NCIt
43NDF-RT
46NINDS
47Novoseek
49OMIM
50OMIM via Orphanet
54PubMed
55QIAGEN
60SNOMED-CT via Orphanet
64Tumor Gene Family of Databases
65UMLS
66UMLS via Orphanet