Aliases & Classifications for Agoraphobia

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Sources:
9Disease Ontology, 11DISEASES, 43Novoseek, 60UMLS, 55SNOMED-CT, 33MeSH, 38NCIt, 25ICD10
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Agoraphobia, Aliases & Descriptions:

Name: Agoraphobia 9 11 43 60
 
Fear of Open Spaces 9


Classifications:

Malacards categories (disease lists): (See all malacards categories)
Anatomical: Mental diseases


External Ids:

Disease Ontology9 DOID:593
MeSH33 D000379
NCIt38 C34362
ICD1025 F40.0

Summaries for Agoraphobia

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Disease Ontology:9 A phobic disorder involving the specific anxiety about being in a place or situation where escape is difficult or embarrassing or where help may be unavailable.

MalaCards based summary: Agoraphobia, also known as fear of open spaces, is related to panic disorder and anxiety disorder. An important gene associated with Agoraphobia is HTR1A (5-hydroxytryptamine (serotonin) receptor 1A, G protein-coupled), and among its related pathways are Selective Serotonin Reuptake Inhibitor Pathway, Pharmacodynamics and Monoamine Transport. The drug alprazolam and the compounds cholecystokinin tetrapeptide and idazoxan have been mentioned in the context of this disorder. Affiliated tissues include thyroid, brain and cortex, and related mouse phenotypes are nervous system and cardiovascular system.

Wikipedia:63 Agoraphobia is an anxiety disorder characterized by anxiety in situations where the sufferer perceives... more...

Related Diseases for Agoraphobia

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Diseases related to Agoraphobia via text searches within MalaCards or GeneCards Suite gene sharing:

(show top 50)    (show all 54)
idRelated DiseaseScoreTop Affiliating Genes
1panic disorder31.9PTK7, NAGLU, CCKBR, HTR1A
2anxiety disorder31.6MAOA
3social phobia31.3MAOA, HTR1A
4obsessive-compulsive disorder30.9SLC6A2, MAOA, HTR1A
5generalized anxiety disorder30.3USP39, CCKBR, HTR1A, MAOA, SLC6A2
6bipolar disorder29.7SLC6A2, OPRK1, MAOA, HTR1A
7alcohol dependence29.7OPRK1, MAOA
8personality disorder10.5
9oppositional defiant disorder10.4SLC6A2
10neurotic disorder10.3MAOA, HTR1A
11eating disorder10.3
12blindness10.3
13chronic fatigue syndrome10.3HTR1A, MAOA
14serotonin syndrome10.2HTR1A, MAOA
15separation anxiety disorder10.2
16thyroiditis10.2
17gilles de la tourette syndrome10.2HTR1A, MAOA, SLC6A2
18neuroendocrine tumor10.2CCKBR, SLC6A2
19attention deficit-hyperactivity disorder10.2MAOA, SLC6A2
20psychotic disorder10.2HTR1A, MAOA
21anorexia nervosa10.2SLC6A2, MAOA, HTR1A
22mood disorder10.2SLC6A2, MAOA, HTR1A
23irritable bowel syndrome10.1
24hypochondriasis10.1
25amnestic disorder10.1OPRK1, HTR1A
26drug dependence10.1MAOA, OPRK1
27nicotine dependence, protection against10.0MAOA, NAGLU
28obesity10.0CCKBR, HTR1A, MAOA, SLC6A2
29pain agnosia10.0CCKBR, HTR1A, OPRK1
30asthma10.0
31phenylketonuria10.0
32rubinstein-taybi syndrome10.0
33dystonia-11, myoclonic10.0
34histrionic personality disorder10.0
35animal phobia10.0
36post-traumatic stress disorder10.0
37cerebritis10.0
38gastroenteritis10.0
39hyperthyroidism10.0
40labyrinthitis10.0
41meningitis10.0
42porphyria10.0
43sleep disorder10.0
44tuberculous meningitis10.0
45back pain10.0
46seizure disorder10.0
47rheumatic disease10.0
48dementia9.9HTR1A, MAOA, OPRK1
49epilepsy syndrome9.9OPRK1, MAOA, HTR1A
50malignant glioma9.8CCKBR, HTR1A, OPRK1, SLC6A2

Graphical network of the top 20 diseases related to Agoraphobia:



Diseases related to agoraphobia

Symptoms for Agoraphobia

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Drugs & Therapeutics for Agoraphobia

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Drug clinical trials:

Search ClinicalTrials for Agoraphobia

Search NIH Clinical Center for Agoraphobia

Inferred drug relations via UMLS60/NDF-RT39:

Genetic Tests for Agoraphobia

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Anatomical Context for Agoraphobia

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MalaCards organs/tissues related to Agoraphobia:

31
Thyroid, Brain, Cortex, Cingulate cortex, Amygdala, Pituitary

Animal Models for Agoraphobia or affiliated genes

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MGI Mouse Phenotypes related to Agoraphobia:

35
idDescriptionMGI Source AccessionScoreTop Affiliating Genes
1MP:00036318.0NAGLU, STMN1, CCKBR, HTR1A, MAOA, SLC6A2
2MP:00053857.9SLC6A2, PTK7, NAGLU, STMN1, CCKBR, HTR1A
3MP:00053867.6PTK7, NAGLU, CCKBR, HTR1A, MAOA, OPRK1

Publications for Agoraphobia

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Articles related to Agoraphobia:

(show top 50)    (show all 511)
idTitleAuthorsYear
1
The neural representation of emotionally neutral faces and places in patients with panic disorder with agoraphobia. (24176537)
2014
2
Treatment Modality Preferences and Adherence to Group Treatment for Panic Disorder with Agoraphobia. (24136085)
2013
3
Late-onset agoraphobia: general population incidence and evidence for a clinical subtype. (23820832)
2013
4
Longitudinal course of panic disorder with and without agoraphobia using the National Epidemiologic Survey on Alcohol and Related Conditions (NESARC). (23587657)
2013
5
Antianxiety medications for the treatment of complex agoraphobia: pharmacological interventions for a behavioral condition. (22090798)
2011
6
Health anxiety and fear of fear in panic disorder and agoraphobia vs. social phobia: a prospective longitudinal study. (20143435)
2010
7
Nomophobia: the mobile phone in panic disorder with agoraphobia: reducing phobias or worsening of dependence? (20299865)
2010
8
Cognitive-behavioral treatment for panic disorder with agoraphobia: a randomized, controlled trial and cost-effectiveness analysis. (18391051)
2008
9
Low extraversion and high neuroticism as indices of genetic and environmental risk for social phobia, agoraphobia, and animal phobia. (17974937)
2007
10
Panic disorder and the onset of agoraphobia. (16732761)
2006
11
"My new Alfa Romeo GT is not in the garage any more": Cognitive behavioural therapy of panic disorder with agoraphobia co morbid with psychosis. (17099612)
2006
12
Selective cognitive deficits in obsessive-compulsive disorder compared to panic disorder with agoraphobia. (15667435)
2005
13
Treatment of panic disorder with agoraphobia in an anxiety disorders clinic: factors influencing psychiatrists' treatment choices. (14967551)
2004
14
Predictors of work disabilities in patients with panic disorder with agoraphobia. (15276660)
2004
15
Increased probability of remaining in remission from panic disorder with agoraphobia after drug treatment in patients who received concurrent cognitive-behavioural therapy: a follow-up study. (12466636)
2003
16
Are benzodiazepines still the medication of choice for patients with panic disorder with or without agoraphobia? (12900305)
2003
17
Clinical and psychosocial outcome of patients affected by panic disorder with or without agoraphobia: results from a naturalistic follow-up study. (12547305)
2002
18
Long-term treatment of panic disorder with agoraphobia in private practice. (15990481)
2000
19
Preattentive bias for emotional information in panic disorder with agoraphobia. (10369032)
1999
20
Long-term maintenance and discontinuation of imipramine therapy in panic disorder with agoraphobia. (12884888)
1999
21
The observer perspective: biased imagery in social phobia, agoraphobia, and blood/injury phobia. (10402690)
1999
22
Long-term effects of alprazolam on memory: a 3.5 year follow-up of agoraphobia/panic patients. (10077311)
1999
23
The differential effect of personality on computer-based treatment of agoraphobia. (9777283)
1998
24
The role of trauma and dissociation in cognitive-behavioral psychotherapy outcome and maintenance for panic disorder with agoraphobia. (9737056)
1998
25
Embarrassment about the first panic attack predicts agoraphobia in panic disorder patients. (9159975)
1997
26
Brain blood flow in anxiety disorders. OCD, panic disorder with agoraphobia, and post-traumatic stress disorder on 99mTcHMPAO single photon emission tomography (SPET). (9373423)
1997
27
Explicit and implicit memory bias in panic disorder with agoraphobia. (9431730)
1997
28
A meta-analysis of the treatment of panic disorder with or without agoraphobia: a comparison of psychopharmacological, cognitive-behavioral, and combination treatments. (9284865)
1997
29
A comparison of cognitive and guided mastery therapy of agoraphobia. (7755528)
1995
30
Exposure reduced agoraphobia but not panic, and cognitive therapy reduced panic but not agoraphobia. (7910732)
1994
31
Dimensions of agoraphobia assessed by the Mobility Inventory. (8512544)
1993
32
Gender effects and alcohol use in panic disorder with agoraphobia. (8512541)
1993
33
Personality disorders in panic with agoraphobia and major depression. (1600407)
1992
34
The association of panic/agoraphobia and asthma. Contributing factors and clinical implications. (1473713)
1992
35
Biological correlates of panic disorder with agoraphobia: practice perspectives for nurses. (1759863)
1991
36
Mechanisms of change of panic attacks with exposure treatment of agoraphobia. (1679064)
1991
37
Toxic agoraphobia. (2334481)
1990
38
A comparison of DSM-III personality disorders in panic/agoraphobia and obsessive-compulsive disorder. (2340718)
1990
39
Childhood panic disorder with agoraphobia. (2309969)
1990
40
Panic attacks and agoraphobia: low dose clomipramine treatment. (2651491)
1989
41
Factors in the panic-agoraphobia transition. (2635873)
1989
42
Breathing retraining, exposure and a combination of both, in the treatment of panic disorder with agoraphobia. (2575375)
1989
43
Prescribing patterns in agoraphobia with panic attacks. (3336339)
1988
44
The cause and treatment of agoraphobia. (2895623)
1988
45
Thyroid hormones in panic disorder, panic disorder with agoraphobia, and generalized anxiety disorder. (3379028)
1988
46
Autonomic changes after treatment of agoraphobia with panic attacks. (3393620)
1988
47
Alprazolam in panic disorder and agoraphobia: results from a multicenter trial. III. Discontinuation effects. (3282479)
1988
48
The placebo effect in agoraphobia--II. (3411315)
1988
49
The relationship between panic, phobic and anticipatory anxiety in agoraphobia. (3044349)
1988
50
Agoraphobia and parental bereavement. (3435374)
1987

Variations for Agoraphobia

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Expression for genes affiliated with Agoraphobia

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Search GEO for disease gene expression data for Agoraphobia.

Pathways for genes affiliated with Agoraphobia

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Pathways related to Agoraphobia according to GeneCards Suite gene sharing:

idSuper pathways (with members indented)ScoreTop Affiliating Genes
19.8MAOA, HTR1A
2
Show member pathways
Serotonin Transporter Activity36
9.8SLC6A2, MAOA

Compounds for genes affiliated with Agoraphobia

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Compounds related to Agoraphobia according to GeneCards Suite gene sharing:

(show top 50)    (show all 88)
idCompoundScoreTop Affiliating Genes
1cholecystokinin tetrapeptide4310.2PTK7, CCKBR
2idazoxan4310.2MAOA, HTR1A
3bufotenine43 28 1212.2MAOA, HTR1A
4carbon-114310.1MAOA, HTR1A
5m-tyramine4310.1SLC6A2, MAOA
6zolmitriptan43 28 1212.1HTR1A, MAOA
7milnacipran43 49 1212.1HTR1A, SLC6A2
8rizatriptan43 28 1212.1HTR1A, MAOA
9nomifensine43 28 1212.1MAOA, SLC6A2
10naratriptan43 28 1212.1MAOA, HTR1A
11phentermine43 1211.0MAOA, SLC6A2
12d amphetamine4310.0SLC6A2, MAOA
13pseudoephedrine43 24 1211.9SLC6A2, MAOA
14p-chloroamphetamine439.9MAOA, SLC6A2, HTR1A
15mdma439.9SLC6A2, HTR1A, MAOA
16maoa439.9SLC6A2, MAOA, HTR1A
17ephedrine43 28 1211.9MAOA, SLC6A2
18benzodiazepine439.9MAOA, CCKBR, PTK7
19mianserin43 28 1211.9MAOA, HTR1A, SLC6A2
20sertraline43 28 49 24 1213.9HTR1A, MAOA, SLC6A2
21fluvoxamine43 49 1211.9HTR1A, MAOA, SLC6A2
22raclopride43 2810.9CCKBR, HTR1A
23clomipramine43 49 1211.9MAOA, HTR1A, SLC6A2
24paroxetine43 49 28 1212.9HTR1A, SLC6A2, MAOA
25benzodiazepines439.9MAOA, CCKBR
26desipramine43 49 1211.9MAOA, SLC6A2, HTR1A
27fluoxetine43 49 28 1212.9SLC6A2, HTR1A, MAOA
28imipramine43 28 49 24 1213.8MAOA, SLC6A2, HTR1A
29haloperidol43 49 28 2 1213.8HTR1A, SLC6A2, CCKBR
30tetrapeptide439.7PTK7, OPRK1, CCKBR
31sumatriptan43 28 59 49 24 1214.7MAOA, OPRK1, HTR1A
32indole439.7MAOA, OPRK1, CCKBR
33levodopa43 1210.6OPRK1, HTR1A, MAOA
34citalopram43 49 24 1212.6MAOA, PTK7, HTR1A, SLC6A2
35dopac439.6OPRK1, MAOA
36amine439.5SLC6A2, OPRK1, MAOA
37acth439.4OPRK1, HTR1A, PTK7, CCKBR
38amitriptyline43 28 49 1212.4MAOA, HTR1A, OPRK1, SLC6A2
39amphetamine43 49 1211.4CCKBR, SLC6A2, MAOA, OPRK1
40acetylcholine43 49 28 24 1213.4OPRK1, SLC6A2, HTR1A, CCKBR
41nmda43 2810.4CCKBR, HTR1A, MAOA, OPRK1
42nicotine43 28 49 1212.3OPRK1, CCKBR, SLC6A2, MAOA
43lead439.3OPRK1, NAGLU, SLC6A2, CCKBR
44gaba439.3SLC6A2, OPRK1, MAOA, PTK7
45cocaine43 1210.2SLC6A2, OPRK1, CCKBR
465-hydroxytryptamine439.2HTR1A, MAOA, SLC6A2
47norepinephrine43 24 1211.1HTR1A, PTK7, SLC6A2, OPRK1, MAOA
48superoxide43 249.9STMN1, NAGLU, OPRK1, SLC6A2
49glutamate438.8OPRK1, CCKBR, STMN1, SLC6A2, MAOA
50dopamine43 28 24 1211.4OPRK1, MAOA, HTR1A, CCKBR, NAGLU, PTK7

GO Terms for genes affiliated with Agoraphobia

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Cellular components related to Agoraphobia according to GeneCards Suite gene sharing:

idNameGO IDScoreTop Affiliating Genes
1integral component of plasma membraneGO:00058878.7SLC6A2, OPRK1, HTR1A, CCKBR, PTK7

Biological processes related to Agoraphobia according to GeneCards Suite gene sharing:

idNameGO IDScoreTop Affiliating Genes
1sensory perceptionGO:00076009.6OPRK1, CCKBR
2phospholipase C-activating G-protein coupled receptor signaling pathwayGO:00072009.4OPRK1, CCKBR
3synaptic transmissionGO:00072689.2SLC6A2, OPRK1, MAOA

Products for genes affiliated with Agoraphobia

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Sources for Agoraphobia

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3CDC
13ExPASy
14FMA
22GTR
23HGMD
24HMDB
25ICD10
26ICD10 via Orphanet
27ICD9CM
28IUPHAR
29KEGG
33MeSH
34MESH via Orphanet
35MGI
38NCIt
39NDF-RT
42NINDS
43Novoseek
45OMIM
46OMIM via Orphanet
50PubMed
51QIAGEN
56SNOMED-CT via Orphanet
60UMLS
61UMLS via Orphanet