MCID: AGR002
MIFTS: 46

Agoraphobia malady

Neuronal diseases category

Summaries for Agoraphobia

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8Disease Ontology, 63Wikipedia, 32MalaCards
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Disease Ontology:8 A phobic disorder involving the specific anxiety about being in a place or situation where escape is difficult or embarrassing or where help may be unavailable.

MalaCards: Agoraphobia, also known as fear of open spaces, is related to panic disorder and anxiety disorder. An important gene associated with Agoraphobia is HTR1A (5-hydroxytryptamine (serotonin) receptor 1A, G protein-coupled). The drug alprazolam and the compounds cholecystokinin tetrapeptide and m-tyramine have been mentioned in the context of this disorder. Affiliated tissues include thyroid, brain and pituitary, and related mouse phenotypes are nervous system and behavior/neurological.

Wikipedia:63 Agoraphobia (from Greek αγορά, \"gathering place\"; and φόβος, φοβία, -phobia) is an... more...

Aliases & Classifications for Agoraphobia

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Sources:
8Disease Ontology, 10DISEASES, 44Novoseek, 60UMLS, 34MeSH, 56SNOMED-CT, 39NCIt, 25ICD10
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Classifications:

Malacards categories (disease lists): (See all malacards categories)
Anatomical: Neuronal diseases


Aliases & Descriptions:

agoraphobia 8 10 44 60
fear of open spaces 8


External Ids:

Disease Ontology8 DOID:593
MeSH34 D000379
NCIt39 C34362
ICD1025 F40.0

Related Diseases for Agoraphobia

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Sources:
17GeneCards, 18GeneDecks
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Diseases related to Agoraphobia via text searches within MalaCards or GeneCards/GeneDecks gene sharing:

(show top 50)    (show all 51)
idRelated DiseaseScoreTop Affiliating Genes
1panic disorder31.7PTK7, NAGLU, HTR1A, CCKBR
2anxiety disorder30.9CCKBR, HTR1A, MAOA, SLC6A2, PTK7
3social phobia30.7MAOA, HTR1A
4obsessive-compulsive disorder30.5HTR1A, MAOA, SLC6A2
5generalized anxiety disorder30.5CCKBR, HTR1A, USP39, MAOA, SLC6A2
6bipolar disorder30.0MAOA, HTR1A
7alcohol dependence29.8MAOA, OPRK1
8mood disorder29.8SLC6A2, MAOA, HTR1A
9personality disorder10.5
10major depressive disorder10.3
11separation anxiety disorder10.2
12eating disorder10.2
13specific phobia10.1
14thyroiditis10.1
15hypochondriasis10.0
16obsessive-compulsive personality disorder10.0
17animal phobia10.0
18irritable bowel syndrome10.0
19dissociative disorder10.0
20sleep disorder10.0
21endogenous depression10.0MAOA
22borderline personality disorder10.0MAOA
23parkinson's disease10.0HTR1A, MAOA
24morphine dependence10.0OPRK1
25anorexia nervosa10.0SLC6A2, MAOA, HTR1A
26gilles de la tourette syndrome10.0HTR1A, MAOA, SLC6A2
27amnestic disorder10.0HTR1A, OPRK1
28serotonin syndrome10.0HTR1A, MAOA
29neuroblastoma10.0SLC6A2
30pain agnosia10.0OPRK1, HTR1A, CCKBR
31attention deficit hyperactivity disorder10.0MAOA, SLC6A2
32ischemia10.0HTR1A, OPRK1, NAGLU, SLC6A2
33schizophrenia10.0PTK7, SLC6A2, MAOA, OPRK1, HTR1A, CCKBR
34mitral valve prolapse9.9
35histrionic personality disorder9.9
36cerebritis9.9
37phenylketonuria9.9
38post-traumatic stress disorder9.9
39asthma9.9
40gastroenteritis9.9
41hyperthyroidism9.9
42labyrinthitis9.9
43meningitis9.9
44mental depression9.9
45phobic disorder9.9
46physical disorder9.9
47porphyria9.9
48speech disorder9.9
49substance abuse9.9
50substance dependence9.9

Graphical network of the top 20 diseases related to Agoraphobia:



Diseases related to agoraphobia

Clinical Features for Agoraphobia

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Drugs & Therapeutics for Agoraphobia

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Sources:
5CenterWatch, 41NIH Clinical Center, 6ClinicalTrials, 60UMLS, 40NDF-RT
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Approved drugs:

Search CenterWatch for Agoraphobia

Drug clinical trials:

Search ClinicalTrials for Agoraphobia

Search NIH Clinical Center for Agoraphobia

Search CenterWatch for Agoraphobia

Inferred drug relations via UMLS60/NDF-RT40:

Genetic Tests for Agoraphobia

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Anatomical Context for Agoraphobia

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32MalaCards
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MalaCards organs/tissues related to Agoraphobia:

32
Thyroid, Brain, Pituitary, Cortex

Animal Models for Agoraphobia or affiliated genes

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Sources:
36MGI
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MGI Mouse Phenotypes related to Agoraphobia:

36
idDescriptionMGI Source AccessionScoreTop Affiliating Genes
1MP:00036317.8HTR1A, STMN1, MAOA, NAGLU, RGS7, SLC6A2
2MP:00053867.6PTK7, CCKBR, HTR1A, OPRK1, MAOA, NAGLU

Publications for Agoraphobia

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Sources:
50PubMed
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Articles related to Agoraphobia:

(show top 50)    (show all 493)
idTitleAuthorsYear
1
Alpha absolute power measurement in panic disorder with agoraphobia patients. (23820098)
2013
2
A controlled study of agoraphobia and the independent effect of virtual reality exposure therapy. (22790176)
2013
3
Noninvasive brain stimulation by radioelectric asymmetric conveyor in the treatment of agoraphobia: open-label, naturalistic study. (22163156)
2011
4
Virtual reality interoceptive exposure for the treatment of panic disorder and agoraphobia. (20543274)
2010
5
Cognitive mediation of clinical improvement after intensive exposure therapy of agoraphobia and social phobia. (20037922)
2010
6
Mechanisms of change in cognitive therapy for panic disorder with agoraphobia. (17727812)
2008
7
Agoraphobia between panic and phobias: clinical epidemiology from the Sesto Fiorentino Study. (18396188)
2008
8
Belief disconfirmation versus habituation approaches to situational exposure in panic disorder with agoraphobia: a pilot study. (17296165)
2007
9
Emptiness in agoraphobia patients. (17915656)
2007
10
Personality traits in early phases of panic disorder: implications on the presence of agoraphobia, clinical severity and short-term outcome. (17087790)
2006
11
A meta-analysis of the efficacy of psycho- and pharmacotherapy in panic disorder with and without agoraphobia. (16005982)
2005
12
Perceived criticism predicts severity of anxiety symptoms after behavioral treatment in patients with obsessive-compulsive disorder and panic disorder with agoraphobia. (12652634)
2003
13
Internet-based telehealth system for the treatment of agoraphobia. (14511446)
2003
14
Australian and New Zealand clinical practice guidelines for the treatment of panic disorder and agoraphobia. (14636376)
2003
15
Attribution of improvement to medication and increased risk of relapse of panic disorder with agoraphobia. (12601232)
2003
16
Clinical and psychosocial outcome of patients affected by panic disorder with or without agoraphobia: results from a naturalistic follow-up study. (12547305)
2002
17
Naturalistic manner of benzodiazepine use and cognitive behavioral therapy outcome in panic disorder with agoraphobia. (12214810)
2002
18
Patterns of personality pathology in patients with generalized anxiety disorder, panic disorder with and without agoraphobia, and social phobia. (11236815)
2001
19
Reducing therapist contact in cognitive behaviour therapy for panic disorder and agoraphobia in primary care: global measures of outcome in a randomised controlled trial. (11224967)
2000
20
Visuo-spatial attention processes in panic disorder with agoraphobia: a pilot study using a visual target discrimination task. (10951609)
2000
21
Preattentive bias for emotional information in panic disorder with agoraphobia. (10369032)
1999
22
Long-term effects of alprazolam on memory: a 3.5 year follow-up of agoraphobia/panic patients. (10077311)
1999
23
Prefrontal enlargement of CSF spaces in agoraphobia: a qualitative CT-scan study. (10509377)
1999
24
Recognition bias for safe faces in panic disorder with agoraphobia. (9642851)
1998
25
Interoceptive exposure versus breathing retraining within cognitive-behavioural therapy for panic disorder with agoraphobia. (9051281)
1997
26
Study and course of the psychological profile in 77 patients expressing panic disorder with agoraphobia after cognitive behaviour therapy with or without buspirone. (8996712)
1997
27
Interpretive bias for benign sensations in panic disorder with agoraphobia. (9168339)
1997
28
Soft signs in children of parents with agoraphobia. (8919714)
1996
29
Does exposure to internal cues enhance exposure to external cues in agoraphobia with panic? A pilot controlled study of self-exposure. (8838693)
1996
30
Agoraphobia and panic states. Panel report. (7650279)
1995
31
Adinazolam-SR in panic disorder with agoraphobia: relationship of daily dose to efficacy. (7737960)
1995
32
Treatment of late-onset agoraphobia secondary to depression. (8574994)
1995
33
Memory functions, alprazolam and exposure therapy: a controlled longitudinal study of agoraphobia with panic disorder. (7892364)
1994
34
Alprazolam and exposure alone and combined in panic disorder with agoraphobia. A controlled study in London and Toronto. (8101126)
1993
35
Use of medical services and treatment for panic disorder with agoraphobia and for social phobia. (1525731)
1992
36
Biological correlates of panic disorder with agoraphobia: practice perspectives for nurses. (1759863)
1991
37
Mechanisms of change of panic attacks with exposure treatment of agoraphobia. (1679064)
1991
38
Hyperventilation-induced panic attacks in panic disorder with agoraphobia. (1904781)
1991
39
Behavioral, cognitive, and pharmacological treatments of panic disorder with agoraphobia: critique and synthesis. (2002125)
1991
40
Risk factors for the onset of Diagnostic Interview Schedule/DSM-III agoraphobia in a prospective, population-based study. (2393340)
1990
41
A contribution of fluorescent lighting to agoraphobia. (2236367)
1990
42
Guided mastery treatment of agoraphobia: beyond stimulus exposure. (1980360)
1990
43
Sleep studies and neurochemical correlates in panic disorder and agoraphobia. (2293254)
1990
44
Generalization of therapeutic changes in agoraphobia: the role of perceived self-efficacy. (2567745)
1989
45
Autonomic changes after treatment of agoraphobia with panic attacks. (3393620)
1988
46
Prodromal symptoms in panic disorder with agoraphobia. (3195676)
1988
47
Bio-informational processing in agoraphobia. (3190652)
1988
48
Behavioral inhibition in children of parents with panic disorder and agoraphobia. A controlled study. (3358645)
1988
49
Panic disorder and agoraphobia: fear of fear or fear of the symptoms produced by hyperventilation? (3325529)
1987
50
Construction and constriction in agoraphobia. (3676131)
1987

Genetic Variations for Agoraphobia

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Expression for genes affiliated with Agoraphobia

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Sources:
1BioGPS, 15Gene Expression Omnibus DataSets
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Expression patterns in normal tissues for genes affiliated with Agoraphobia

Search GEO for disease gene expression data for Agoraphobia.

Pathways for genes affiliated with Agoraphobia

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Compounds for genes affiliated with Agoraphobia

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Sources:
44Novoseek, 28IUPHAR, 11DrugBank, 49PharmGKB, 24HMDB, 59Tocris Bioscience, 2BitterDB
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Compounds related to Agoraphobia according to GeneCards/GeneDecks:

(show top 50)    (show all 77)
idCompoundScoreTop Affiliating Genes
1cholecystokinin tetrapeptide4410.4PTK7, CCKBR
2m-tyramine4410.4SLC6A2, MAOA
3bufotenine28 44 1112.4HTR1A, MAOA
4idazoxan4410.4HTR1A, MAOA
5carbon-114410.3HTR1A, MAOA
6zolmitriptan44 28 1112.3HTR1A, MAOA
7naratriptan44 28 1112.3HTR1A, MAOA
8milnacipran44 49 1112.3HTR1A, SLC6A2
9nomifensine44 28 1112.3MAOA, SLC6A2
10rizatriptan44 28 1112.3HTR1A, MAOA
11MMDA1110.3MAOA, SLC6A2
12phentermine44 1111.3MAOA, SLC6A2
13d amphetamine4410.2SLC6A2, MAOA
14pseudoephedrine44 11 2412.2MAOA, SLC6A2
15ephedrine28 44 1112.2MAOA, SLC6A2
16raclopride44 2811.2CCKBR, HTR1A
17p-chloroamphetamine4410.2SLC6A2, MAOA, HTR1A
18mdma4410.2SLC6A2, MAOA, HTR1A
19maoa4410.2SLC6A2, MAOA, HTR1A
20mianserin28 44 1112.2HTR1A, MAOA, SLC6A2
21sertraline44 28 49 11 2414.2SLC6A2, MAOA, HTR1A
22fluvoxamine44 49 1112.2HTR1A, MAOA, SLC6A2
23clomipramine44 49 1112.2HTR1A, MAOA, SLC6A2
24paroxetine44 49 28 1113.2SLC6A2, MAOA, HTR1A
25benzodiazepine4410.2CCKBR, MAOA, PTK7
26desipramine44 49 1112.1SLC6A2, MAOA, HTR1A
27fluoxetine49 44 28 1113.1SLC6A2, MAOA, HTR1A
28benzodiazepines4410.1CCKBR, MAOA
29Tapentadol1110.1OPRK1, SLC6A2
30imipramine44 49 28 11 2414.1HTR1A, MAOA, SLC6A2
31sumatriptan44 28 59 49 11 2415.1HTR1A, OPRK1, MAOA
32indole4410.1MAOA, OPRK1, CCKBR
33tetrapeptide4410.0PTK7, OPRK1, CCKBR
34Ephedra1110.0SLC6A2, MAOA
35citalopram49 44 11 2412.9PTK7, SLC6A2, MAOA, HTR1A
36amitriptyline44 49 28 1112.9HTR1A, OPRK1, MAOA, SLC6A2
37amphetamine44 1110.9CCKBR, OPRK1, MAOA, SLC6A2
38acth449.8CCKBR, HTR1A, OPRK1, PTK7
39nicotine44 49 28 1112.8CCKBR, OPRK1, MAOA, SLC6A2
40lead449.8SLC6A2, NAGLU, OPRK1, CCKBR
41levodopa44 1110.8HTR1A, OPRK1, MAOA
42gaba449.7PTK7, SLC6A2, MAOA, OPRK1
43amine449.7SLC6A2, MAOA, OPRK1
44haloperidol44 28 2 49 1113.7SLC6A2, HTR1A, CCKBR
45nmda44 2810.7MAOA, OPRK1, HTR1A, CCKBR
46tramadol44 49 1111.6SLC6A2, OPRK1
47norepinephrine44 11 2411.6HTR1A, OPRK1, MAOA, SLC6A2, PTK7
48chloride449.5OPRK1, STMN1, SLC6A2, SLC26A4
49acetylcholine44 49 28 11 2413.5CCKBR, HTR1A, OPRK1, SLC6A2
50dopamine44 28 11 2412.1PTK7, CCKBR, HTR1A, OPRK1, MAOA, NAGLU

GO Terms for genes affiliated with Agoraphobia

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16Gene Ontology
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Biological processes related to Agoraphobia according to GeneCards/GeneDecks:

idNameGO IDScoreTop Affiliating Genes
1sensory perceptionGO:0076009.6OPRK1, CCKBR
2spliceosomal complex assemblyGO:0002459.0SNRPD2, USP39

Products for genes affiliated with Agoraphobia

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Sources for Agoraphobia

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3CDC
13ExPASy
14FMA
22GTR
23HGMD
24HMDB
25ICD10
26ICD10 via Orphanet
27ICD9CM
28IUPHAR
29KEGG
34MeSH
35MESH via Orphanet
36MGI
39NCIt
40NDF-RT
43NINDS
44Novoseek
46OMIM
47OMIM via Orphanet
50PubMed
51QIAGEN
57SNOMED-CT via Orphanet
60UMLS
61UMLS via Orphanet