MCID: AGR002
MIFTS: 49

Agoraphobia malady

Mental diseases category
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Summaries for Agoraphobia

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Sources:
8Disease Ontology, 65Wikipedia, 33MalaCards
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Disease Ontology:8 A phobic disorder involving the specific anxiety about being in a place or situation where escape is difficult or embarrassing or where help may be unavailable.

MalaCards: Agoraphobia, also known as fear of open spaces, is related to panic disorder and social phobia. An important gene associated with Agoraphobia is HTR1A (5-hydroxytryptamine (serotonin) receptor 1A, G protein-coupled), and among its related pathways are Selective Serotonin Reuptake Inhibitor Pathway, Pharmacodynamics and Monoamine Transport. The drug alprazolam and the compounds cholecystokinin tetrapeptide and idazoxan have been mentioned in the context of this disorder. Affiliated tissues include thyroid, brain and pituitary, and related mouse phenotypes are nervous system and cardiovascular system.

Wikipedia:65 Agoraphobia (from Greek ?????, \"open space\" and -?????, -phobia) is an anxiety disorder characterized... more...

Aliases & Classifications for Agoraphobia

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8Disease Ontology, 10DISEASES, 45Novoseek, 62UMLS, 40NCIt, 58SNOMED-CT, 35MeSH, 25ICD10
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Classifications:

Malacards categories (disease lists): (See all malacards categories)
Anatomical: Mental diseases


Aliases & Descriptions:

agoraphobia 8 10 45 62
fear of open spaces 8


External Ids:

Disease Ontology8 DOID:593
NCIt40 C34362
MeSH35 D000379
ICD1025 F40.0

Related Diseases for Agoraphobia

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Sources:
17GeneCards, 18GeneDecks
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Diseases related to Agoraphobia via text searches within MalaCards or GeneCards/GeneDecks gene sharing:

(show top 50)    (show all 52)
idRelated DiseaseScoreTop Affiliating Genes
1panic disorder31.8HTR1A, CCKBR, NAGLU, PTK7
2social phobia31.0MAOA, HTR1A
3anxiety disorder31.0MAOA
4obsessive-compulsive disorder30.7MAOA, SLC6A2, HTR1A
5generalized anxiety disorder30.4SLC6A2, MAOA, HTR1A, CCKBR, USP39
6bipolar disorder30.0MAOA, HTR1A
7alcohol dependence29.9OPRK1, MAOA
8personality disorder10.4
9eating disorder10.3
10blindness10.3
11thyroiditis10.2
12oppositional defiant disorder10.1SLC6A2
13separation anxiety disorder10.1
14animal phobia10.1
15irritable bowel syndrome10.1
16hypochondriasis10.1
17specific phobia10.1
18chronic fatigue syndrome10.1MAOA, HTR1A
19serotonin syndrome10.1HTR1A, MAOA
20gilles de la tourette syndrome10.0HTR1A, MAOA, SLC6A2
21neuroendocrine tumor10.0CCKBR, SLC6A2
22anorexia nervosa10.0HTR1A, MAOA, SLC6A2
23mood disorder10.0SLC6A2, HTR1A, MAOA
24attention deficit hyperactivity disorder10.0SLC6A2, MAOA
25psychotic disorder10.0HTR1A, MAOA
26amnestic disorder10.0HTR1A, OPRK1
27drug dependence10.0MAOA, OPRK1
28obesity10.0MAOA, SLC6A2, HTR1A, CCKBR
29pain agnosia10.0OPRK1, CCKBR, HTR1A
30dementia10.0MAOA, HTR1A, OPRK1
31epilepsy syndrome10.0HTR1A, MAOA, OPRK1
32histrionic personality disorder9.9
33major depressive disorder9.9
34mitral valve prolapse9.9
35phenylketonuria9.9
36post-traumatic stress disorder9.9
37cerebritis9.9
38asthma9.9
39gastroenteritis9.9
40hyperthyroidism9.9
41labyrinthitis9.9
42meningitis9.9
43porphyria9.9
44tuberculous meningitis9.9
45back pain9.9
46seizure disorder9.9
47rheumatic disease9.9
48malignant glioma9.9SLC6A2, OPRK1, HTR1A, CCKBR
49ischemia9.9NAGLU, HTR1A, OPRK1, SLC6A2
50parkinson's disease9.9OPRK1, MAOA, HTR1A, CCKBR, SLC6A2

Graphical network of the top 20 diseases related to Agoraphobia:



Diseases related to agoraphobia

Symptoms for Agoraphobia

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Drugs & Therapeutics for Agoraphobia

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Sources:
42NIH Clinical Center, 6ClinicalTrials, 62UMLS, 41NDF-RT
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Drug clinical trials:

Search ClinicalTrials for Agoraphobia

Search NIH Clinical Center for Agoraphobia

Inferred drug relations via UMLS62/NDF-RT41:

Genetic Tests for Agoraphobia

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Anatomical Context for Agoraphobia

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33MalaCards
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MalaCards organs/tissues related to Agoraphobia:

33
Thyroid, Brain, Pituitary, Cortex

Animal Models for Agoraphobia or affiliated genes

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Sources:
37MGI
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MGI Mouse Phenotypes related to Agoraphobia:

37
idDescriptionMGI Source AccessionScoreTop Affiliating Genes
1MP:00036318.0NAGLU, STMN1, CCKBR, HTR1A, MAOA, SLC6A2
2MP:00053857.9SLC6A2, PTK7, NAGLU, STMN1, CCKBR, HTR1A
3MP:00053867.6PTK7, NAGLU, CCKBR, HTR1A, MAOA, OPRK1

Publications for Agoraphobia

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Sources:
52PubMed
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Articles related to Agoraphobia:

(show top 50)    (show all 487)
idTitleAuthorsYear
1
The neural representation of emotionally neutral faces and places in patients with panic disorder with agoraphobia. (24176537)
2014
2
Treatment Modality Preferences and Adherence to Group Treatment for Panic Disorder with Agoraphobia. (24136085)
2013
3
Late-onset agoraphobia: general population incidence and evidence for a clinical subtype. (23820832)
2013
4
Longitudinal course of panic disorder with and without agoraphobia using the National Epidemiologic Survey on Alcohol and Related Conditions (NESARC). (23587657)
2013
5
Antianxiety medications for the treatment of complex agoraphobia: pharmacological interventions for a behavioral condition. (22090798)
2011
6
Health anxiety and fear of fear in panic disorder and agoraphobia vs. social phobia: a prospective longitudinal study. (20143435)
2010
7
Nomophobia: the mobile phone in panic disorder with agoraphobia: reducing phobias or worsening of dependence? (20299865)
2010
8
Cognitive-behavioral treatment for panic disorder with agoraphobia: a randomized, controlled trial and cost-effectiveness analysis. (18391051)
2008
9
Low extraversion and high neuroticism as indices of genetic and environmental risk for social phobia, agoraphobia, and animal phobia. (17974937)
2007
10
Panic disorder and the onset of agoraphobia. (16732761)
2006
11
Selective cognitive deficits in obsessive-compulsive disorder compared to panic disorder with agoraphobia. (15667435)
2005
12
Treatment of panic disorder with agoraphobia in an anxiety disorders clinic: factors influencing psychiatrists' treatment choices. (14967551)
2004
13
Predictors of work disabilities in patients with panic disorder with agoraphobia. (15276660)
2004
14
Increased probability of remaining in remission from panic disorder with agoraphobia after drug treatment in patients who received concurrent cognitive-behavioural therapy: a follow-up study. (12466636)
2003
15
Are benzodiazepines still the medication of choice for patients with panic disorder with or without agoraphobia? (12900305)
2003
16
Clinical and psychosocial outcome of patients affected by panic disorder with or without agoraphobia: results from a naturalistic follow-up study. (12547305)
2002
17
Long-term treatment of panic disorder with agoraphobia in private practice. (15990481)
2000
18
Preattentive bias for emotional information in panic disorder with agoraphobia. (10369032)
1999
19
Long-term maintenance and discontinuation of imipramine therapy in panic disorder with agoraphobia. (12884888)
1999
20
The observer perspective: biased imagery in social phobia, agoraphobia, and blood/injury phobia. (10402690)
1999
21
Long-term effects of alprazolam on memory: a 3.5 year follow-up of agoraphobia/panic patients. (10077311)
1999
22
The differential effect of personality on computer-based treatment of agoraphobia. (9777283)
1998
23
The role of trauma and dissociation in cognitive-behavioral psychotherapy outcome and maintenance for panic disorder with agoraphobia. (9737056)
1998
24
Embarrassment about the first panic attack predicts agoraphobia in panic disorder patients. (9159975)
1997
25
Brain blood flow in anxiety disorders. OCD, panic disorder with agoraphobia, and post-traumatic stress disorder on 99mTcHMPAO single photon emission tomography (SPET). (9373423)
1997
26
Explicit and implicit memory bias in panic disorder with agoraphobia. (9431730)
1997
27
A meta-analysis of the treatment of panic disorder with or without agoraphobia: a comparison of psychopharmacological, cognitive-behavioral, and combination treatments. (9284865)
1997
28
The benefit of an insight-oriented and experiential approach on panic and agoraphobia symptoms. Results of a controlled comparison of client-centered therapy alone and in combination with behavioral exposure. (9403918)
1997
29
A comparison of cognitive and guided mastery therapy of agoraphobia. (7755528)
1995
30
Exposure reduced agoraphobia but not panic, and cognitive therapy reduced panic but not agoraphobia. (7910732)
1994
31
Dimensions of agoraphobia assessed by the Mobility Inventory. (8512544)
1993
32
Gender effects and alcohol use in panic disorder with agoraphobia. (8512541)
1993
33
Personality disorders in panic with agoraphobia and major depression. (1600407)
1992
34
The association of panic/agoraphobia and asthma. Contributing factors and clinical implications. (1473713)
1992
35
Biological correlates of panic disorder with agoraphobia: practice perspectives for nurses. (1759863)
1991
36
Mechanisms of change of panic attacks with exposure treatment of agoraphobia. (1679064)
1991
37
Toxic agoraphobia. (2334481)
1990
38
A comparison of DSM-III personality disorders in panic/agoraphobia and obsessive-compulsive disorder. (2340718)
1990
39
Childhood panic disorder with agoraphobia. (2309969)
1990
40
Panic attacks and agoraphobia: low dose clomipramine treatment. (2651491)
1989
41
Factors in the panic-agoraphobia transition. (2635873)
1989
42
Breathing retraining, exposure and a combination of both, in the treatment of panic disorder with agoraphobia. (2575375)
1989
43
Prescribing patterns in agoraphobia with panic attacks. (3336339)
1988
44
The cause and treatment of agoraphobia. (2895623)
1988
45
Thyroid hormones in panic disorder, panic disorder with agoraphobia, and generalized anxiety disorder. (3379028)
1988
46
Autonomic changes after treatment of agoraphobia with panic attacks. (3393620)
1988
47
Alprazolam in panic disorder and agoraphobia: results from a multicenter trial. III. Discontinuation effects. (3282479)
1988
48
The placebo effect in agoraphobia--II. (3411315)
1988
49
The relationship between panic, phobic and anticipatory anxiety in agoraphobia. (3044349)
1988
50
Agoraphobia and parental bereavement. (3435374)
1987

Variations for Agoraphobia

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Expression for genes affiliated with Agoraphobia

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2BioGPS, 15Gene Expression Omnibus DataSets
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Expression patterns in normal tissues for genes affiliated with Agoraphobia

Search GEO for disease gene expression data for Agoraphobia.

Pathways for genes affiliated with Agoraphobia

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50PathCards, 51PharmGKB, 38NCBI BioSystems Database
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Pathways related to Agoraphobia according to GeneCards/GeneDecks:

idSuper pathways (with members indented)ScoreTop Affiliating Genes
19.8MAOA, HTR1A
2
Show member pathways
Serotonin Transporter Activity38
9.8SLC6A2, MAOA

Compounds for genes affiliated with Agoraphobia

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Sources:
45Novoseek, 29IUPHAR, 11DrugBank, 51PharmGKB, 24HMDB, 3BitterDB, 61Tocris Bioscience
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Compounds related to Agoraphobia according to GeneCards/GeneDecks:

(show top 50)    (show all 88)
idCompoundScoreTop Affiliating Genes
1cholecystokinin tetrapeptide4510.2PTK7, CCKBR
2idazoxan4510.2MAOA, HTR1A
3bufotenine45 29 1112.2MAOA, HTR1A
4carbon-114510.1MAOA, HTR1A
5m-tyramine4510.1MAOA, SLC6A2
6zolmitriptan45 29 1112.1MAOA, HTR1A
7milnacipran45 51 1112.1HTR1A, SLC6A2
8naratriptan45 29 1112.1HTR1A, MAOA
9nomifensine45 29 1112.1MAOA, SLC6A2
10rizatriptan45 29 1112.1HTR1A, MAOA
11phentermine45 1111.0MAOA, SLC6A2
12d amphetamine4510.0MAOA, SLC6A2
13pseudoephedrine45 24 1111.9SLC6A2, MAOA
14p-chloroamphetamine459.9MAOA, SLC6A2, HTR1A
15mdma459.9SLC6A2, MAOA, HTR1A
16maoa459.9SLC6A2, HTR1A, MAOA
17ephedrine45 29 1111.9MAOA, SLC6A2
18mianserin45 29 1111.9HTR1A, MAOA, SLC6A2
19benzodiazepine459.9MAOA, CCKBR, PTK7
20sertraline45 29 51 24 1113.9SLC6A2, MAOA, HTR1A
21fluvoxamine45 51 1111.9HTR1A, MAOA, SLC6A2
22raclopride45 2910.9CCKBR, HTR1A
23clomipramine45 51 1111.9SLC6A2, MAOA, HTR1A
24paroxetine45 51 29 1112.9SLC6A2, MAOA, HTR1A
25benzodiazepines459.9MAOA, CCKBR
26desipramine45 51 1111.9HTR1A, SLC6A2, MAOA
27fluoxetine45 51 29 1112.9HTR1A, MAOA, SLC6A2
28piperazine45 1110.8HTR1A, SLC6A2
29imipramine45 29 51 24 1113.8HTR1A, SLC6A2, MAOA
30haloperidol45 51 29 3 1113.8SLC6A2, CCKBR, HTR1A
31tetrapeptide459.7PTK7, OPRK1, CCKBR
32sumatriptan45 29 61 51 24 1114.7MAOA, HTR1A, OPRK1
33indole459.7CCKBR, OPRK1, MAOA
34levodopa45 1110.6MAOA, HTR1A, OPRK1
35citalopram45 51 24 1112.6HTR1A, PTK7, MAOA, SLC6A2
36amine459.5MAOA, OPRK1, SLC6A2
37acth459.4OPRK1, CCKBR, HTR1A, PTK7
38amitriptyline45 29 51 1112.4MAOA, HTR1A, SLC6A2, OPRK1
39amphetamine45 51 1111.4CCKBR, SLC6A2, OPRK1, MAOA
40acetylcholine45 51 29 24 1113.4OPRK1, SLC6A2, HTR1A, CCKBR
41nmda45 2910.4MAOA, CCKBR, OPRK1, HTR1A
42nicotine45 29 51 1112.3CCKBR, OPRK1, SLC6A2, MAOA
43lead459.3OPRK1, SLC6A2, NAGLU, CCKBR
44gaba459.3SLC6A2, MAOA, OPRK1, PTK7
45cocaine45 1110.2CCKBR, OPRK1, SLC6A2
465-hydroxytryptamine459.2MAOA, SLC6A2, HTR1A
47norepinephrine45 24 1111.1HTR1A, MAOA, OPRK1, SLC6A2, PTK7
48superoxide45 249.9NAGLU, STMN1, OPRK1, SLC6A2
49glutamate458.8MAOA, CCKBR, STMN1, SLC6A2, OPRK1
50dopamine45 29 24 1111.4OPRK1, SLC6A2, MAOA, PTK7, HTR1A, CCKBR

GO Terms for genes affiliated with Agoraphobia

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16Gene Ontology
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Cellular components related to Agoraphobia according to GeneCards/GeneDecks:

idNameGO IDScoreTop Affiliating Genes
1integral component of plasma membraneGO:0058878.7SLC6A2, OPRK1, HTR1A, CCKBR, PTK7

Biological processes related to Agoraphobia according to GeneCards/GeneDecks:

idNameGO IDScoreTop Affiliating Genes
1sensory perceptionGO:0076009.6OPRK1, CCKBR
2phospholipase C-activating G-protein coupled receptor signaling pathwayGO:0072009.4OPRK1, CCKBR
3synaptic transmissionGO:0072689.2SLC6A2, OPRK1, MAOA

Products for genes affiliated with Agoraphobia

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Sources for Agoraphobia

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4CDC
13ExPASy
14FMA
22GTR
23HGMD
24HMDB
25ICD10
26ICD10 via Orphanet
27ICD9CM
29IUPHAR
30KEGG
35MeSH
36MESH via Orphanet
37MGI
40NCIt
41NDF-RT
44NINDS
45Novoseek
47OMIM
48OMIM via Orphanet
52PubMed
53QIAGEN
59SNOMED-CT via Orphanet
62UMLS
63UMLS via Orphanet