MCID: AGR002
MIFTS: 51

Agoraphobia malady

Mental diseases category
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Summaries for Agoraphobia

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Disease Ontology:8 A phobic disorder involving the specific anxiety about being in a place or situation where escape is difficult or embarrassing or where help may be unavailable.

MalaCards based summary: Agoraphobia, also known as fear of open spaces, is related to panic disorder and anxiety disorder. An important gene associated with Agoraphobia is HTR1A (5-hydroxytryptamine (serotonin) receptor 1A, G protein-coupled), and among its related pathways are Selective Serotonin Reuptake Inhibitor Pathway, Pharmacodynamics and Monoamine Transport. The drug alprazolam and the compounds cholecystokinin tetrapeptide and idazoxan have been mentioned in the context of this disorder. Affiliated tissues include thyroid, brain and cortex, and related mouse phenotypes are nervous system and cardiovascular system.

Wikipedia:65 Agoraphobia (from Greek ?????, \"Large public square/Marketplace\" and -?????, -phobia) is an anxiety... more...

Aliases & Classifications for Agoraphobia

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Sources:
8Disease Ontology, 10DISEASES, 44Novoseek, 62UMLS, 34MeSH, 57SNOMED-CT, 39NCIt, 25ICD10
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Agoraphobia, Aliases & Descriptions:

Name: Agoraphobia 8 10 44 62
 
Fear of Open Spaces 8 62


Classifications:

Malacards categories (disease lists): (See all malacards categories)
Anatomical: Mental diseases


External Ids:

Disease Ontology8 DOID:593
MeSH34 D000379
NCIt39 C34362
ICD1025 F40.0

Related Diseases for Agoraphobia

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Diseases related to Agoraphobia via text searches within MalaCards or GeneCards/GeneDecks gene sharing:

(show top 50)    (show all 53)
idRelated DiseaseScoreTop Affiliating Genes
1panic disorder31.9HTR1A, CCKBR, NAGLU, PTK7
2anxiety disorder31.6MAOA
3social phobia31.4MAOA, HTR1A
4obsessive-compulsive disorder30.9MAOA, SLC6A2, HTR1A
5bipolar disorder30.4MAOA, HTR1A
6generalized anxiety disorder30.3SLC6A2, MAOA, HTR1A, CCKBR, USP39
7alcohol dependence29.7OPRK1, MAOA
8personality disorder10.5
9oppositional defiant disorder10.4SLC6A2
10eating disorder10.3
11blindness10.3
12chronic fatigue syndrome10.3MAOA, HTR1A
13serotonin syndrome10.2HTR1A, MAOA
14separation anxiety disorder10.2
15thyroiditis10.2
16gilles de la tourette syndrome10.2HTR1A, MAOA, SLC6A2
17neuroendocrine tumor10.2CCKBR, SLC6A2
18anorexia nervosa10.2HTR1A, MAOA, SLC6A2
19mood disorder10.2SLC6A2, HTR1A, MAOA
20attention deficit hyperactivity disorder10.2SLC6A2, MAOA
21psychotic disorder10.1HTR1A, MAOA
22irritable bowel syndrome10.1
23animal phobia10.1
24hypochondriasis10.1
25specific phobia10.1
26amnestic disorder10.1HTR1A, OPRK1
27drug dependence10.1MAOA, OPRK1
28obesity10.0MAOA, SLC6A2, HTR1A, CCKBR
29pain agnosia10.0OPRK1, CCKBR, HTR1A
30asthma10.0
31major depressive disorder10.0
32phenylketonuria10.0
33post-traumatic stress disorder10.0
34histrionic personality disorder10.0
35mitral valve prolapse10.0
36cerebritis10.0
37gastroenteritis10.0
38hyperthyroidism10.0
39labyrinthitis10.0
40meningitis10.0
41porphyria10.0
42sleep disorder10.0
43tuberculous meningitis10.0
44back pain10.0
45seizure disorder10.0
46rheumatic disease10.0
47dementia9.9MAOA, HTR1A, OPRK1
48epilepsy syndrome9.9HTR1A, MAOA, OPRK1
49malignant glioma9.8SLC6A2, OPRK1, HTR1A, CCKBR
50ischemia9.7NAGLU, HTR1A, OPRK1, SLC6A2

Graphical network of the top 20 diseases related to Agoraphobia:



Diseases related to agoraphobia

Symptoms for Agoraphobia

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Drugs & Therapeutics for Agoraphobia

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Drug clinical trials:

Search ClinicalTrials for Agoraphobia

Search NIH Clinical Center for Agoraphobia

Inferred drug relations via UMLS62/NDF-RT40:

Genetic Tests for Agoraphobia

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Anatomical Context for Agoraphobia

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MalaCards organs/tissues related to Agoraphobia:

32
Thyroid, Brain, Cortex, Cingulate cortex, Amygdala, Pituitary

Animal Models for Agoraphobia or affiliated genes

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MGI Mouse Phenotypes related to Agoraphobia:

36
idDescriptionMGI Source AccessionScoreTop Affiliating Genes
1MP:00036318.0NAGLU, STMN1, CCKBR, HTR1A, MAOA, SLC6A2
2MP:00053857.9SLC6A2, PTK7, NAGLU, STMN1, CCKBR, HTR1A
3MP:00053867.6PTK7, NAGLU, CCKBR, HTR1A, MAOA, OPRK1

Publications for Agoraphobia

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Articles related to Agoraphobia:

(show top 50)    (show all 504)
idTitleAuthorsYear
1
The neural representation of emotionally neutral faces and places in patients with panic disorder with agoraphobia. (24176537)
2014
2
Treatment Modality Preferences and Adherence to Group Treatment for Panic Disorder with Agoraphobia. (24136085)
2013
3
Late-onset agoraphobia: general population incidence and evidence for a clinical subtype. (23820832)
2013
4
Longitudinal course of panic disorder with and without agoraphobia using the National Epidemiologic Survey on Alcohol and Related Conditions (NESARC). (23587657)
2013
5
Antianxiety medications for the treatment of complex agoraphobia: pharmacological interventions for a behavioral condition. (22090798)
2011
6
Health anxiety and fear of fear in panic disorder and agoraphobia vs. social phobia: a prospective longitudinal study. (20143435)
2010
7
Nomophobia: the mobile phone in panic disorder with agoraphobia: reducing phobias or worsening of dependence? (20299865)
2010
8
Cognitive-behavioral treatment for panic disorder with agoraphobia: a randomized, controlled trial and cost-effectiveness analysis. (18391051)
2008
9
Low extraversion and high neuroticism as indices of genetic and environmental risk for social phobia, agoraphobia, and animal phobia. (17974937)
2007
10
Panic disorder and the onset of agoraphobia. (16732761)
2006
11
"My new Alfa Romeo GT is not in the garage any more": Cognitive behavioural therapy of panic disorder with agoraphobia co morbid with psychosis. (17099612)
2006
12
Selective cognitive deficits in obsessive-compulsive disorder compared to panic disorder with agoraphobia. (15667435)
2005
13
Treatment of panic disorder with agoraphobia in an anxiety disorders clinic: factors influencing psychiatrists' treatment choices. (14967551)
2004
14
Predictors of work disabilities in patients with panic disorder with agoraphobia. (15276660)
2004
15
Increased probability of remaining in remission from panic disorder with agoraphobia after drug treatment in patients who received concurrent cognitive-behavioural therapy: a follow-up study. (12466636)
2003
16
Are benzodiazepines still the medication of choice for patients with panic disorder with or without agoraphobia? (12900305)
2003
17
Clinical and psychosocial outcome of patients affected by panic disorder with or without agoraphobia: results from a naturalistic follow-up study. (12547305)
2002
18
Long-term treatment of panic disorder with agoraphobia in private practice. (15990481)
2000
19
Preattentive bias for emotional information in panic disorder with agoraphobia. (10369032)
1999
20
Long-term maintenance and discontinuation of imipramine therapy in panic disorder with agoraphobia. (12884888)
1999
21
The observer perspective: biased imagery in social phobia, agoraphobia, and blood/injury phobia. (10402690)
1999
22
Long-term effects of alprazolam on memory: a 3.5 year follow-up of agoraphobia/panic patients. (10077311)
1999
23
The differential effect of personality on computer-based treatment of agoraphobia. (9777283)
1998
24
The role of trauma and dissociation in cognitive-behavioral psychotherapy outcome and maintenance for panic disorder with agoraphobia. (9737056)
1998
25
Embarrassment about the first panic attack predicts agoraphobia in panic disorder patients. (9159975)
1997
26
Brain blood flow in anxiety disorders. OCD, panic disorder with agoraphobia, and post-traumatic stress disorder on 99mTcHMPAO single photon emission tomography (SPET). (9373423)
1997
27
Explicit and implicit memory bias in panic disorder with agoraphobia. (9431730)
1997
28
A meta-analysis of the treatment of panic disorder with or without agoraphobia: a comparison of psychopharmacological, cognitive-behavioral, and combination treatments. (9284865)
1997
29
A comparison of cognitive and guided mastery therapy of agoraphobia. (7755528)
1995
30
Exposure reduced agoraphobia but not panic, and cognitive therapy reduced panic but not agoraphobia. (7910732)
1994
31
Dimensions of agoraphobia assessed by the Mobility Inventory. (8512544)
1993
32
Gender effects and alcohol use in panic disorder with agoraphobia. (8512541)
1993
33
Personality disorders in panic with agoraphobia and major depression. (1600407)
1992
34
The association of panic/agoraphobia and asthma. Contributing factors and clinical implications. (1473713)
1992
35
Biological correlates of panic disorder with agoraphobia: practice perspectives for nurses. (1759863)
1991
36
Mechanisms of change of panic attacks with exposure treatment of agoraphobia. (1679064)
1991
37
Toxic agoraphobia. (2334481)
1990
38
A comparison of DSM-III personality disorders in panic/agoraphobia and obsessive-compulsive disorder. (2340718)
1990
39
Childhood panic disorder with agoraphobia. (2309969)
1990
40
Panic attacks and agoraphobia: low dose clomipramine treatment. (2651491)
1989
41
Factors in the panic-agoraphobia transition. (2635873)
1989
42
Breathing retraining, exposure and a combination of both, in the treatment of panic disorder with agoraphobia. (2575375)
1989
43
Prescribing patterns in agoraphobia with panic attacks. (3336339)
1988
44
The cause and treatment of agoraphobia. (2895623)
1988
45
Thyroid hormones in panic disorder, panic disorder with agoraphobia, and generalized anxiety disorder. (3379028)
1988
46
Autonomic changes after treatment of agoraphobia with panic attacks. (3393620)
1988
47
Alprazolam in panic disorder and agoraphobia: results from a multicenter trial. III. Discontinuation effects. (3282479)
1988
48
The placebo effect in agoraphobia--II. (3411315)
1988
49
The relationship between panic, phobic and anticipatory anxiety in agoraphobia. (3044349)
1988
50
Agoraphobia and parental bereavement. (3435374)
1987

Variations for Agoraphobia

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Expression for genes affiliated with Agoraphobia

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Expression patterns in normal tissues for genes affiliated with Agoraphobia

Search GEO for disease gene expression data for Agoraphobia.

Pathways for genes affiliated with Agoraphobia

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Pathways related to Agoraphobia according to GeneCards/GeneDecks:

idSuper pathways (with members indented)ScoreTop Affiliating Genes
19.8MAOA, HTR1A
2
Show member pathways
Serotonin Transporter Activity37
9.8SLC6A2, MAOA

Compounds for genes affiliated with Agoraphobia

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Compounds related to Agoraphobia according to GeneCards/GeneDecks:

(show top 50)    (show all 88)
idCompoundScoreTop Affiliating Genes
1cholecystokinin tetrapeptide4410.2PTK7, CCKBR
2idazoxan4410.2MAOA, HTR1A
3bufotenine44 28 1112.2MAOA, HTR1A
4carbon-114410.1MAOA, HTR1A
5m-tyramine4410.1MAOA, SLC6A2
6zolmitriptan44 28 1112.1MAOA, HTR1A
7milnacipran44 50 1112.1HTR1A, SLC6A2
8naratriptan44 28 1112.1HTR1A, MAOA
9nomifensine44 28 1112.1MAOA, SLC6A2
10rizatriptan44 28 1112.1HTR1A, MAOA
11phentermine44 1111.0MAOA, SLC6A2
12d amphetamine4410.0MAOA, SLC6A2
13pseudoephedrine44 24 1111.9SLC6A2, MAOA
14p-chloroamphetamine449.9MAOA, SLC6A2, HTR1A
15mdma449.9SLC6A2, MAOA, HTR1A
16maoa449.9SLC6A2, HTR1A, MAOA
17ephedrine44 28 1111.9MAOA, SLC6A2
18mianserin44 28 1111.9HTR1A, MAOA, SLC6A2
19benzodiazepine449.9MAOA, CCKBR, PTK7
20sertraline44 28 50 24 1113.9SLC6A2, MAOA, HTR1A
21fluvoxamine44 50 1111.9HTR1A, MAOA, SLC6A2
22raclopride44 2810.9CCKBR, HTR1A
23clomipramine44 50 1111.9SLC6A2, MAOA, HTR1A
24paroxetine44 50 28 1112.9SLC6A2, MAOA, HTR1A
25benzodiazepines449.9MAOA, CCKBR
26desipramine44 50 1111.9HTR1A, SLC6A2, MAOA
27fluoxetine44 50 28 1112.9HTR1A, MAOA, SLC6A2
28piperazine44 1110.8HTR1A, SLC6A2
29imipramine44 28 50 24 1113.8HTR1A, SLC6A2, MAOA
30haloperidol44 50 28 2 1113.8SLC6A2, CCKBR, HTR1A
31tetrapeptide449.7PTK7, OPRK1, CCKBR
32sumatriptan44 28 61 50 24 1114.7MAOA, HTR1A, OPRK1
33indole449.7CCKBR, OPRK1, MAOA
34levodopa44 1110.6MAOA, HTR1A, OPRK1
35citalopram44 50 24 1112.6HTR1A, PTK7, MAOA, SLC6A2
36amine449.5MAOA, OPRK1, SLC6A2
37acth449.4OPRK1, CCKBR, HTR1A, PTK7
38amitriptyline44 28 50 1112.4MAOA, HTR1A, SLC6A2, OPRK1
39amphetamine44 50 1111.4CCKBR, SLC6A2, OPRK1, MAOA
40acetylcholine44 50 28 24 1113.4OPRK1, SLC6A2, HTR1A, CCKBR
41nmda44 2810.4MAOA, CCKBR, OPRK1, HTR1A
42nicotine44 28 50 1112.3CCKBR, OPRK1, SLC6A2, MAOA
43lead449.3OPRK1, SLC6A2, NAGLU, CCKBR
44gaba449.3SLC6A2, MAOA, OPRK1, PTK7
45cocaine44 1110.2CCKBR, OPRK1, SLC6A2
465-hydroxytryptamine449.2MAOA, SLC6A2, HTR1A
47norepinephrine44 24 1111.1HTR1A, MAOA, OPRK1, SLC6A2, PTK7
48superoxide44 249.9NAGLU, STMN1, OPRK1, SLC6A2
49glutamate448.8MAOA, CCKBR, STMN1, SLC6A2, OPRK1
50dopamine44 28 24 1111.4OPRK1, SLC6A2, MAOA, PTK7, HTR1A, CCKBR

GO Terms for genes affiliated with Agoraphobia

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Cellular components related to Agoraphobia according to GeneCards/GeneDecks:

idNameGO IDScoreTop Affiliating Genes
1integral component of plasma membraneGO:0058878.7SLC6A2, OPRK1, HTR1A, CCKBR, PTK7

Biological processes related to Agoraphobia according to GeneCards/GeneDecks:

idNameGO IDScoreTop Affiliating Genes
1sensory perceptionGO:0076009.6OPRK1, CCKBR
2phospholipase C-activating G-protein coupled receptor signaling pathwayGO:0072009.4OPRK1, CCKBR
3synaptic transmissionGO:0072689.2SLC6A2, OPRK1, MAOA

Products for genes affiliated with Agoraphobia

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Sources for Agoraphobia

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3CDC
13ExPASy
14FMA
22GTR
23HGMD
24HMDB
25ICD10
26ICD10 via Orphanet
27ICD9CM
28IUPHAR
29KEGG
34MeSH
35MESH via Orphanet
36MGI
39NCIt
40NDF-RT
43NINDS
44Novoseek
46OMIM
47OMIM via Orphanet
51PubMed
52QIAGEN
58SNOMED-CT via Orphanet
62UMLS
63UMLS via Orphanet