MCID: AGR002
MIFTS: 49

Agoraphobia malady

Mental diseases category

Summaries for Agoraphobia

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Sources:
9Disease Ontology, 66Wikipedia, 34MalaCards
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Disease Ontology:9 A phobic disorder involving the specific anxiety about being in a place or situation where escape is difficult or embarrassing or where help may be unavailable.

MalaCards: Agoraphobia, also known as fear of open spaces, is related to panic disorder and social phobia. An important gene associated with Agoraphobia is HTR1A (5-hydroxytryptamine (serotonin) receptor 1A, G protein-coupled), and among its related pathways are Selective Serotonin Reuptake Inhibitor Pathway, Pharmacodynamics and Monoamine Transport. The drug alprazolam and the compounds cholecystokinin tetrapeptide and idazoxan have been mentioned in the context of this disorder. Affiliated tissues include thyroid, brain and pituitary, and related mouse phenotypes are nervous system and cardiovascular system.

Wikipedia:66 Agoraphobia (from Greek ?????, \"open space\" and -?????, -phobia) is an anxiety disorder characterized... more...

Aliases & Classifications for Agoraphobia

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Sources:
9Disease Ontology, 11DISEASES, 46Novoseek, 63UMLS, 41NCIt, 59SNOMED-CT, 36MeSH, 26ICD10
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Classifications:

Malacards categories (disease lists): (See all malacards categories)
Anatomical: Mental diseases


Aliases & Descriptions:

agoraphobia 9 11 46 63
fear of open spaces 9


External Ids:

Disease Ontology9 DOID:593
NCIt41 C34362
MeSH36 D000379
ICD1026 F40.0

Related Diseases for Agoraphobia

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Sources:
18GeneCards, 19GeneDecks
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Diseases related to Agoraphobia via text searches within MalaCards or GeneCards/GeneDecks gene sharing:

(show top 50)    (show all 52)
idRelated DiseaseScoreTop Affiliating Genes
1panic disorder31.8HTR1A, CCKBR, NAGLU, PTK7
2social phobia31.0MAOA, HTR1A
3anxiety disorder31.0MAOA
4obsessive-compulsive disorder30.7MAOA, SLC6A2, HTR1A
5generalized anxiety disorder30.4SLC6A2, MAOA, HTR1A, CCKBR, USP39
6bipolar disorder30.0MAOA, HTR1A
7alcohol dependence29.9OPRK1, MAOA
8personality disorder10.4
9eating disorder10.3
10blindness10.3
11thyroiditis10.2
12oppositional defiant disorder10.1SLC6A2
13separation anxiety disorder10.1
14animal phobia10.1
15irritable bowel syndrome10.1
16hypochondriasis10.1
17specific phobia10.1
18chronic fatigue syndrome10.1MAOA, HTR1A
19serotonin syndrome10.1HTR1A, MAOA
20gilles de la tourette syndrome10.0HTR1A, MAOA, SLC6A2
21neuroendocrine tumor10.0CCKBR, SLC6A2
22anorexia nervosa10.0HTR1A, MAOA, SLC6A2
23mood disorder10.0SLC6A2, HTR1A, MAOA
24attention deficit hyperactivity disorder10.0SLC6A2, MAOA
25psychotic disorder10.0HTR1A, MAOA
26amnestic disorder10.0HTR1A, OPRK1
27drug dependence10.0MAOA, OPRK1
28obesity10.0MAOA, SLC6A2, HTR1A, CCKBR
29pain agnosia10.0OPRK1, CCKBR, HTR1A
30dementia10.0MAOA, HTR1A, OPRK1
31epilepsy syndrome10.0HTR1A, MAOA, OPRK1
32histrionic personality disorder9.9
33major depressive disorder9.9
34mitral valve prolapse9.9
35phenylketonuria9.9
36post-traumatic stress disorder9.9
37cerebritis9.9
38asthma9.9
39gastroenteritis9.9
40hyperthyroidism9.9
41labyrinthitis9.9
42meningitis9.9
43porphyria9.9
44tuberculous meningitis9.9
45back pain9.9
46seizure disorder9.9
47rheumatic disease9.9
48malignant glioma9.9SLC6A2, OPRK1, HTR1A, CCKBR
49ischemia9.9NAGLU, HTR1A, OPRK1, SLC6A2
50parkinson's disease9.9OPRK1, MAOA, HTR1A, CCKBR, SLC6A2

Graphical network of the top 20 diseases related to Agoraphobia:



Diseases related to agoraphobia

Symptoms for Agoraphobia

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Drugs & Therapeutics for Agoraphobia

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Sources:
6CenterWatch, 43NIH Clinical Center, 7ClinicalTrials, 63UMLS, 42NDF-RT
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Approved drugs:

Search CenterWatch for Agoraphobia

Drug clinical trials:

Search ClinicalTrials for Agoraphobia

Search NIH Clinical Center for Agoraphobia

Search CenterWatch for Agoraphobia

Inferred drug relations via UMLS63/NDF-RT42:

Genetic Tests for Agoraphobia

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Anatomical Context for Agoraphobia

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34MalaCards
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MalaCards organs/tissues related to Agoraphobia:

34
Thyroid, Brain, Pituitary, Cortex

Animal Models for Agoraphobia or affiliated genes

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Sources:
38MGI
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MGI Mouse Phenotypes related to Agoraphobia:

38
idDescriptionMGI Source AccessionScoreTop Affiliating Genes
1MP:00036318.0NAGLU, STMN1, CCKBR, HTR1A, MAOA, SLC6A2
2MP:00053857.9SLC6A2, PTK7, NAGLU, STMN1, CCKBR, HTR1A
3MP:00053867.6PTK7, NAGLU, CCKBR, HTR1A, MAOA, OPRK1

Publications for Agoraphobia

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Sources:
53PubMed
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Articles related to Agoraphobia:

(show top 50)    (show all 487)
idTitleAuthorsYear
1
The neural representation of emotionally neutral faces and places in patients with panic disorder with agoraphobia. (24176537)
2014
2
Treatment Modality Preferences and Adherence to Group Treatment for Panic Disorder with Agoraphobia. (24136085)
2013
3
Late-onset agoraphobia: general population incidence and evidence for a clinical subtype. (23820832)
2013
4
Longitudinal course of panic disorder with and without agoraphobia using the National Epidemiologic Survey on Alcohol and Related Conditions (NESARC). (23587657)
2013
5
Antianxiety medications for the treatment of complex agoraphobia: pharmacological interventions for a behavioral condition. (22090798)
2011
6
Health anxiety and fear of fear in panic disorder and agoraphobia vs. social phobia: a prospective longitudinal study. (20143435)
2010
7
Nomophobia: the mobile phone in panic disorder with agoraphobia: reducing phobias or worsening of dependence? (20299865)
2010
8
Cognitive-behavioral treatment for panic disorder with agoraphobia: a randomized, controlled trial and cost-effectiveness analysis. (18391051)
2008
9
Low extraversion and high neuroticism as indices of genetic and environmental risk for social phobia, agoraphobia, and animal phobia. (17974937)
2007
10
Panic disorder and the onset of agoraphobia. (16732761)
2006
11
Selective cognitive deficits in obsessive-compulsive disorder compared to panic disorder with agoraphobia. (15667435)
2005
12
Treatment of panic disorder with agoraphobia in an anxiety disorders clinic: factors influencing psychiatrists' treatment choices. (14967551)
2004
13
Predictors of work disabilities in patients with panic disorder with agoraphobia. (15276660)
2004
14
Increased probability of remaining in remission from panic disorder with agoraphobia after drug treatment in patients who received concurrent cognitive-behavioural therapy: a follow-up study. (12466636)
2003
15
Are benzodiazepines still the medication of choice for patients with panic disorder with or without agoraphobia? (12900305)
2003
16
Clinical and psychosocial outcome of patients affected by panic disorder with or without agoraphobia: results from a naturalistic follow-up study. (12547305)
2002
17
Long-term treatment of panic disorder with agoraphobia in private practice. (15990481)
2000
18
Preattentive bias for emotional information in panic disorder with agoraphobia. (10369032)
1999
19
Long-term maintenance and discontinuation of imipramine therapy in panic disorder with agoraphobia. (12884888)
1999
20
The observer perspective: biased imagery in social phobia, agoraphobia, and blood/injury phobia. (10402690)
1999
21
Long-term effects of alprazolam on memory: a 3.5 year follow-up of agoraphobia/panic patients. (10077311)
1999
22
The differential effect of personality on computer-based treatment of agoraphobia. (9777283)
1998
23
The role of trauma and dissociation in cognitive-behavioral psychotherapy outcome and maintenance for panic disorder with agoraphobia. (9737056)
1998
24
Embarrassment about the first panic attack predicts agoraphobia in panic disorder patients. (9159975)
1997
25
Brain blood flow in anxiety disorders. OCD, panic disorder with agoraphobia, and post-traumatic stress disorder on 99mTcHMPAO single photon emission tomography (SPET). (9373423)
1997
26
Explicit and implicit memory bias in panic disorder with agoraphobia. (9431730)
1997
27
A meta-analysis of the treatment of panic disorder with or without agoraphobia: a comparison of psychopharmacological, cognitive-behavioral, and combination treatments. (9284865)
1997
28
The benefit of an insight-oriented and experiential approach on panic and agoraphobia symptoms. Results of a controlled comparison of client-centered therapy alone and in combination with behavioral exposure. (9403918)
1997
29
A comparison of cognitive and guided mastery therapy of agoraphobia. (7755528)
1995
30
Exposure reduced agoraphobia but not panic, and cognitive therapy reduced panic but not agoraphobia. (7910732)
1994
31
Dimensions of agoraphobia assessed by the Mobility Inventory. (8512544)
1993
32
Gender effects and alcohol use in panic disorder with agoraphobia. (8512541)
1993
33
Personality disorders in panic with agoraphobia and major depression. (1600407)
1992
34
The association of panic/agoraphobia and asthma. Contributing factors and clinical implications. (1473713)
1992
35
Biological correlates of panic disorder with agoraphobia: practice perspectives for nurses. (1759863)
1991
36
Mechanisms of change of panic attacks with exposure treatment of agoraphobia. (1679064)
1991
37
Toxic agoraphobia. (2334481)
1990
38
A comparison of DSM-III personality disorders in panic/agoraphobia and obsessive-compulsive disorder. (2340718)
1990
39
Childhood panic disorder with agoraphobia. (2309969)
1990
40
Panic attacks and agoraphobia: low dose clomipramine treatment. (2651491)
1989
41
Factors in the panic-agoraphobia transition. (2635873)
1989
42
Breathing retraining, exposure and a combination of both, in the treatment of panic disorder with agoraphobia. (2575375)
1989
43
Prescribing patterns in agoraphobia with panic attacks. (3336339)
1988
44
The cause and treatment of agoraphobia. (2895623)
1988
45
Thyroid hormones in panic disorder, panic disorder with agoraphobia, and generalized anxiety disorder. (3379028)
1988
46
Autonomic changes after treatment of agoraphobia with panic attacks. (3393620)
1988
47
Alprazolam in panic disorder and agoraphobia: results from a multicenter trial. III. Discontinuation effects. (3282479)
1988
48
The placebo effect in agoraphobia--II. (3411315)
1988
49
The relationship between panic, phobic and anticipatory anxiety in agoraphobia. (3044349)
1988
50
Agoraphobia and parental bereavement. (3435374)
1987

Variations for Agoraphobia

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Expression for genes affiliated with Agoraphobia

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Sources:
2BioGPS, 16Gene Expression Omnibus DataSets
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Expression patterns in normal tissues for genes affiliated with Agoraphobia

Search GEO for disease gene expression data for Agoraphobia.

Pathways for genes affiliated with Agoraphobia

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Sources:
51PathCards, 52PharmGKB, 39NCBI BioSystems Database
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Pathways related to Agoraphobia according to GeneCards/GeneDecks:

idSuper pathways (with members indented)ScoreTop Affiliating Genes
19.8MAOA, HTR1A
2
Show member pathways
Serotonin Transporter Activity39
9.8SLC6A2, MAOA

Compounds for genes affiliated with Agoraphobia

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Sources:
46Novoseek, 30IUPHAR, 12DrugBank, 52PharmGKB, 25HMDB, 3BitterDB, 62Tocris Bioscience
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Compounds related to Agoraphobia according to GeneCards/GeneDecks:

(show top 50)    (show all 88)
idCompoundScoreTop Affiliating Genes
1cholecystokinin tetrapeptide4610.2PTK7, CCKBR
2idazoxan4610.2MAOA, HTR1A
3bufotenine46 30 1212.2MAOA, HTR1A
4carbon-114610.1MAOA, HTR1A
5m-tyramine4610.1MAOA, SLC6A2
6zolmitriptan46 30 1212.1MAOA, HTR1A
7milnacipran46 52 1212.1HTR1A, SLC6A2
8naratriptan46 30 1212.1HTR1A, MAOA
9nomifensine46 30 1212.1MAOA, SLC6A2
10rizatriptan46 30 1212.1HTR1A, MAOA
11phentermine46 1211.0MAOA, SLC6A2
12d amphetamine4610.0MAOA, SLC6A2
13pseudoephedrine46 25 1211.9SLC6A2, MAOA
14p-chloroamphetamine469.9MAOA, SLC6A2, HTR1A
15mdma469.9SLC6A2, MAOA, HTR1A
16maoa469.9SLC6A2, HTR1A, MAOA
17ephedrine46 30 1211.9MAOA, SLC6A2
18mianserin46 30 1211.9HTR1A, MAOA, SLC6A2
19benzodiazepine469.9MAOA, CCKBR, PTK7
20sertraline46 30 52 25 1213.9SLC6A2, MAOA, HTR1A
21fluvoxamine46 52 1211.9HTR1A, MAOA, SLC6A2
22raclopride46 3010.9CCKBR, HTR1A
23clomipramine46 52 1211.9SLC6A2, MAOA, HTR1A
24paroxetine46 52 30 1212.9SLC6A2, MAOA, HTR1A
25benzodiazepines469.9MAOA, CCKBR
26desipramine46 52 1211.9HTR1A, SLC6A2, MAOA
27fluoxetine46 52 30 1212.9HTR1A, MAOA, SLC6A2
28piperazine46 1210.8HTR1A, SLC6A2
29imipramine46 30 52 25 1213.8HTR1A, SLC6A2, MAOA
30haloperidol46 52 30 3 1213.8SLC6A2, CCKBR, HTR1A
31tetrapeptide469.7PTK7, OPRK1, CCKBR
32sumatriptan46 30 62 52 25 1214.7MAOA, HTR1A, OPRK1
33indole469.7CCKBR, OPRK1, MAOA
34levodopa46 1210.6MAOA, HTR1A, OPRK1
35citalopram46 52 25 1212.6HTR1A, PTK7, MAOA, SLC6A2
36amine469.5MAOA, OPRK1, SLC6A2
37acth469.4OPRK1, CCKBR, HTR1A, PTK7
38amitriptyline46 30 52 1212.4MAOA, HTR1A, SLC6A2, OPRK1
39amphetamine46 52 1211.4CCKBR, SLC6A2, OPRK1, MAOA
40acetylcholine46 52 30 25 1213.4OPRK1, SLC6A2, HTR1A, CCKBR
41nmda46 3010.4MAOA, CCKBR, OPRK1, HTR1A
42nicotine46 30 52 1212.3CCKBR, OPRK1, SLC6A2, MAOA
43lead469.3OPRK1, SLC6A2, NAGLU, CCKBR
44gaba469.3SLC6A2, MAOA, OPRK1, PTK7
45cocaine46 1210.2CCKBR, OPRK1, SLC6A2
465-hydroxytryptamine469.2MAOA, SLC6A2, HTR1A
47norepinephrine46 25 1211.1HTR1A, MAOA, OPRK1, SLC6A2, PTK7
48superoxide46 259.9NAGLU, STMN1, OPRK1, SLC6A2
49glutamate468.8MAOA, CCKBR, STMN1, SLC6A2, OPRK1
50dopamine46 30 25 1211.4OPRK1, SLC6A2, MAOA, PTK7, HTR1A, CCKBR

GO Terms for genes affiliated with Agoraphobia

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Sources:
17Gene Ontology
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Cellular components related to Agoraphobia according to GeneCards/GeneDecks:

idNameGO IDScoreTop Affiliating Genes
1integral component of plasma membraneGO:0058878.7SLC6A2, OPRK1, HTR1A, CCKBR, PTK7

Biological processes related to Agoraphobia according to GeneCards/GeneDecks:

idNameGO IDScoreTop Affiliating Genes
1sensory perceptionGO:0076009.6OPRK1, CCKBR
2phospholipase C-activating G-protein coupled receptor signaling pathwayGO:0072009.4OPRK1, CCKBR
3synaptic transmissionGO:0072689.2SLC6A2, OPRK1, MAOA

Products for genes affiliated with Agoraphobia

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Sources for Agoraphobia

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4CDC
14ExPASy
15FMA
23GTR
24HGMD
25HMDB
26ICD10
27ICD10 via Orphanet
28ICD9CM
30IUPHAR
31KEGG
36MeSH
37MESH via Orphanet
38MGI
41NCIt
42NDF-RT
45NINDS
46Novoseek
48OMIM
49OMIM via Orphanet
53PubMed
54QIAGEN
60SNOMED-CT via Orphanet
63UMLS
64UMLS via Orphanet