Aliases & Classifications for Agraphia

Summaries for Agraphia

Disease Ontology : 12 An acquired writing disorder causing a loss in the ability to communicate through writing, either due to some motor dysfunction or the inability to spell.

MalaCards based summary : Agraphia is related to gerstmann syndrome and dysgraphia, and has symptoms including other symbolic dysfunction An important gene associated with Agraphia is MAPT (Microtubule Associated Protein Tau), and among its related pathways/superpathways are Spinal Cord Injury and Amyotrophic lateral sclerosis (ALS). Affiliated tissues include brain, temporal lobe and occipital lobe, and related phenotypes are Decreased viability with paclitaxel and hematopoietic system

Wikipedia : 72 Agraphia is an acquired neurological disorder causing a loss in the ability to communicate through... more...

Related Diseases for Agraphia

Diseases related to Agraphia via text searches within MalaCards or GeneCards Suite gene sharing:

(show top 50) (show all 85)
id Related Disease Score Top Affiliating Genes
1 gerstmann syndrome 11.1
2 dysgraphia 10.8
3 inclusion body myopathy with early-onset paget disease and frontotemporal dementia 10.8
4 extraosseous ewings sarcoma-primitive neuroepithelial tumor 10.6 GRN PSEN1
5 alexia 10.6
6 autoimmune disease of urogenital tract 10.6 GRN PSEN1
7 propriospinal myoclonus 10.6 GRN MAPT PSEN1
8 isolated focal cortical dysplasia type ic 10.6 GRN MAPT PSEN1
9 cerebral arteritis 10.5 PSEN1 TARDBP
10 seow najjar syndrome 10.5 GRN MAPT TARDBP
11 ceroid lipofuscinosis, neuronal, 11 10.5 GRN MAPT TARDBP
12 simultanagnosia 10.5 GRN PSEN1 TARDBP
13 autotopagnosia 10.5 GRN PSEN1 TARDBP
14 spastic ataxia 2 10.5 PPP3CA TP53
15 akinetic mutism 10.4 CBS GRN PSEN1
16 glucose metabolism disease 10.4 CBS GRN PSEN1
17 personality disorder 10.4 GRN MAPT PSEN1
18 penis basal cell carcinoma 10.4 MAPT PRNP
19 meckel syndrome 10 10.4 BCHE MAPT PSEN1
20 transsexualism 10.4 ACHE BCHE PSEN1
21 cardiomyopathy, dilated, 1u 10.4 MAPT PSEN1 TARDBP
22 hallucinogen abuse 10.3 CBS KANTR
23 supranuclear palsy, progressive atypical 10.3 ACHE CBS GRN MAPT
24 retinal hemangioblastoma 10.3 KANTR TP53
25 riedel's fibrosing thyroiditis 10.2 KANTR MAPT TARDBP
26 diffuse alopecia areata 10.2 GRN KANTR PSEN1
27 inferior myocardial infarction 10.2 KANTR MAPT
28 melanoma, cutaneous malignant, 2 10.2 CBS GRN PSEN1 TARDBP
29 arthrogryposis, lethal, with anterior horn cell disease 10.2 MBP TARDBP
30 nosophobia 10.1 GRN MAPT PRNP PSEN1
31 mixed cell adenoma 10.1 KANTR MBP PSEN1
32 intracranial structure hemangioma 10.1 MAPT PSEN1
33 lynch syndrome 10.1 ACHE BCHE KANTR
34 color agnosia 10.0 KANTR PRNP
35 littre gland carcinoma 10.0 KANTR MBP
36 relapsing fever 10.0 KANTR PRNP PSEN1
37 progressive bulbar palsy 10.0 CBS GRN MAPT PSEN1 TARDBP
38 carotid body cancer 10.0 ACHE BCHE MAPT MBP PSEN1
39 fuchs' endothelial dystrophy 10.0 KANTR MBP PNMA2
40 central nervous system germ cell tumor 10.0 KANTR TP53
41 adenosquamous bile duct carcinoma 10.0 KANTR MBP PNMA2
42 aphasia 9.9
43 cerebritis 9.8
44 dementia 9.8
45 mesenchymal chondrosarcoma 9.8 ACHE CBS GRN MAPT PSEN1 TARDBP
46 pick disease 9.8 ACHE CBS GRN MAPT PSEN1 TARDBP
47 long qt syndrome 5 9.8 GRN MAPT PRNP PSEN1 TARDBP
48 marchiafava bignami disease 9.7
49 lateral sclerosis 9.7
50 creutzfeldt-jakob disease 9.7

Graphical network of the top 20 diseases related to Agraphia:



Diseases related to Agraphia

Symptoms & Phenotypes for Agraphia

UMLS symptoms related to Agraphia:


other symbolic dysfunction

GenomeRNAi Phenotypes related to Agraphia according to GeneCards Suite gene sharing:

26
id Description GenomeRNAi Source Accession Score Top Affiliating Genes
1 Decreased viability with paclitaxel GR00293-A 8.92 DEDD PPP3CA PRTN3 TP53

MGI Mouse Phenotypes related to Agraphia:

44
id Description MGI Source Accession Score Top Affiliating Genes
1 hematopoietic system MP:0005397 10.23 PRTN3 PSEN1 TARDBP TP53 ACHE DEDD
2 homeostasis/metabolism MP:0005376 10.21 ACHE BCHE GRN MAPK14 MAPT MBP
3 cellular MP:0005384 10.18 GRN MAPK14 MAPT MBP POU3F3 PRNP
4 mortality/aging MP:0010768 10.15 PPP3CA PRNP PSEN1 TARDBP TP53 ACHE
5 immune system MP:0005387 10.14 DEDD GRN MAPK14 MAPT MBP PPP3CA
6 nervous system MP:0003631 10.03 ACHE DEDD GRN MAPK14 MAPT MBP
7 muscle MP:0005369 9.92 MAPT PPP3CA PRNP PSEN1 TARDBP TP53
8 no phenotypic analysis MP:0003012 9.7 ACHE GRN MAPT PRNP PRTN3 TARDBP
9 reproductive system MP:0005389 9.61 ACHE BCHE DEDD GRN MAPK14 MBP
10 vision/eye MP:0005391 9.17 ACHE GRN MAPT MBP PRNP PSEN1

Drugs & Therapeutics for Agraphia

Interventional clinical trials:


id Name Status NCT ID Phase Drugs
1 Effectiveness of a Handwriting Intervention Completed NCT02620098
2 Neurobiology of Language Recovery in Aphasia: Natural History and Treatment-Induced Recovery Active, not recruiting NCT01927302

Search NIH Clinical Center for Agraphia

Genetic Tests for Agraphia

Anatomical Context for Agraphia

MalaCards organs/tissues related to Agraphia:

39
Brain, Temporal Lobe, Occipital Lobe, Testes, Parietal Lobe

Publications for Agraphia

Articles related to Agraphia:

(show top 50) (show all 137)
id Title Authors Year
1
Multi-step treatment for acquired alexia and agraphia (part II): a dual-route error scoring system. ( 28421910 )
2017
2
Multi-step treatment for acquired alexia and agraphia (Part I): efficacy, generalisation, and identification of beneficial treatment steps. ( 28421858 )
2017
3
A Case of Anoxic Brain Injury Presenting with Agraphia of kanji in the Foreground. ( 28611641 )
2017
4
Alexia Without Agraphia: A Rare Entity. ( 28690938 )
2017
5
Brain pathology case of the month August 2016 - case 2 A 71 year old man presenting with headache, blurry vision and alexia without agraphia. ( 27647576 )
2016
6
Agraphia in Amyotrophic Lateral Sclerosis with Frontotemporal Lobe Degeneration. ( 26905000 )
2016
7
The nature and treatment of phonological text agraphia. ( 27392251 )
2016
8
Pure agraphia after infarction in the superior and middle portions of the left precentral gyrus: Dissociation between Kanji and Kana. ( 26597609 )
2016
9
Characteristics of Agraphia in Chinese Patients with Alzheimer's Disease and Amnestic Mild Cognitive Impairment. ( 27364791 )
2016
10
The Ege Agraphia Test Battery for Identifying the Writing Disorders in Cases with Mild Cognitive Impairment and Alzheimer's Disease. ( 27711939 )
2016
11
Treatment for Alexia With Agraphia Following Left Ventral Occipito-Temporal Damage: Strengthening Orthographic Representations Common to Reading and Spelling. ( 26110814 )
2015
12
Apraxic agraphia following thalamic damage: Three new cases. ( 26460984 )
2015
13
Alexia Without Agraphia in a Right-Handed Individual Following Right Occipital Stroke. ( 26397830 )
2015
14
Reversible cursive agraphia. ( 26195237 )
2015
15
Agraphia in Mobile Text Messages in a Case of Amyotrophic Lateral Sclerosis with Frontotemporal Dementia. ( 26631894 )
2015
16
Apraxic agraphia following bithalamic damage. ( 25682350 )
2015
17
Agraphia caused by acute right parietal infarction. ( 25564267 )
2015
18
What letters can "learn" from Arabic digits - fMRI-controlled single case therapy study of peripheral agraphia. ( 26186229 )
2015
19
Agraphia in patients with frontotemporal dementia and parkinsonism linked to chromosome 17 with P301L MAPT mutation: dysexecutive, aphasic, apraxic or spatial phenomenon? ( 23121543 )
2014
20
Posterior cerebral artery stroke presenting as alexia without agraphia. ( 24935413 )
2014
21
Agraphia of Kanji (Chinese characters): an early symptom of sporadic Creutzfeldt-Jakob disease in a Japanese patient: a case report. ( 25098795 )
2014
22
Right Brain: A reading specialist with alexia without agraphia: Teacher interrupted. ( 24379102 )
2014
23
Agraphia caused by an infarction in Exner's area. ( 23916761 )
2014
24
Progressive Wallerian Degeneration of the Corpus Callosal Splenium in a Patient with Alexia Without Agraphia: Advanced MR Findings. ( 25489886 )
2014
25
Progressive apraxic agraphia with micrographia presenting as corticobasal syndrome showing extensive Pittsburgh compound B uptake. ( 23589191 )
2013
26
Pure agraphia in Romaji after left inferior frontal gyrus infarction: A case of selective deficit in syllable-to-grapheme conversion in Japanese. ( 23954318 )
2013
27
Clinical presentation of left angular gyrus ischaemic lesion: finger agnosia, acalculia, agraphia, left-right disorientation and episodic autoscopia. ( 23813508 )
2013
28
Agraphia caused by left thalamic hemorrhage. ( 23620716 )
2013
29
Allographic agraphia for single letters. ( 22713390 )
2012
30
Thalamic alexia with agraphia. ( 22593808 )
2012
31
Transient beneficial effects of excitatory theta burst stimulation in a patient with phonological agraphia after left supramarginal gyrus infarction. ( 22296779 )
2012
32
Alexia without agraphia. ( 21675099 )
2011
33
The specificity of notation codes in apraxic agraphia: dissociation between Arabic and alphabetical scripts in a patient with severe ideomotor and visuoconstructional apraxia. ( 20672223 )
2011
34
Compensational strategies for a merchant after stroke with anosognosia for alexia without agraphia. ( 20829414 )
2011
35
Posterior cortical atrophy with prominent alexia without agraphia in a Tourette syndrome. ( 21912890 )
2011
36
Temporal lobe epilepsy manifesting as alexia with agraphia for kanji. ( 21907629 )
2011
37
Chapter 37: alexia and agraphia. ( 19892140 )
2010
38
Hanja (Ideogram) alexia and agraphia in patients with semantic dementia. ( 19967597 )
2010
39
Damage to the upper portion of area 19 and the deep white matter in the left inferior parietal lobe, including the superior longitudinal fasciculus, results in alexia with agraphia. ( 20798545 )
2010
40
Alexia and agraphia with lesions of the angular and supramarginal gyri: evidence for the disruption of sequential processing. ( 19896678 )
2010
41
A treatment sequence for phonological alexia/agraphia. ( 20360466 )
2010
42
Posterior reversible encephalopathy and alexia without agraphia in a patient with Hashimoto's encephalopathy. ( 20119737 )
2010
43
Neologistic jargon aphasia and agraphia in primary progressive aphasia. ( 19033077 )
2009
44
Alexia and agraphia: contrasting perspectives of J.-M. Charcot and J. Hughlings Jackson. ( 18227421 )
2008
45
Alexia with and without agraphia: an assessment of two classical syndromes. ( 19235446 )
2008
46
Alexia without agraphia in Creutzfeldt-Jakob disease. ( 17628601 )
2007
47
Alexia without agraphia in a child with acute disseminated encephalomyelitis. ( 17372144 )
2007
48
Nonconvulsive status epilepticus manifesting as pure alexia (alexia without agraphia). ( 17418645 )
2007
49
Selective alexia and agraphia sparing numbers-a case study. ( 17083972 )
2007
50
Do dual-route models accurately predict reading and spelling performance in individuals with acquired alexia and agraphia? ( 17482218 )
2007

Variations for Agraphia

Expression for Agraphia

Search GEO for disease gene expression data for Agraphia.

Pathways for Agraphia

Pathways related to Agraphia according to GeneCards Suite gene sharing:

id Super pathways Score Top Affiliating Genes
1 11.62 MBP PPP3CA TP53
2
Show member pathways
11.55 MAPK14 PPP3CA TP53
3 11.53 MAPT MBP PRNP PSEN1 TARDBP
4 11.36 MAPK14 PPP3CA TP53
5 11.1 MAPK14 PPP3CA PSEN1
6 10.86 MAPT PRNP TP53

GO Terms for Agraphia

Cellular components related to Agraphia according to GeneCards Suite gene sharing:

id Name GO ID Score Top Affiliating Genes
1 nucleus GO:0005634 9.44 ACHE CBS DEDD MAPK14 MAPT MBP

Biological processes related to Agraphia according to GeneCards Suite gene sharing:

id Name GO ID Score Top Affiliating Genes
1 3-UTR-mediated mRNA stabilization GO:0070935 9.37 MAPK14 TARDBP
2 negative regulation of protein phosphorylation GO:0001933 9.33 PRNP PSEN1 TARDBP
3 amyloid precursor protein metabolic process GO:0042982 9.26 ACHE PSEN1
4 cellular response to drug GO:0035690 9.13 PPP3CA PRNP TP53
5 cellular response to beta-amyloid GO:1904646 9.02 PSEN1
6 astrocyte activation GO:0048143 8.32 MAPT

Molecular functions related to Agraphia according to GeneCards Suite gene sharing:

id Name GO ID Score Top Affiliating Genes
1 identical protein binding GO:0042802 9.8 BCHE CBS MAPT PRNP TARDBP TP53
2 beta-amyloid binding GO:0001540 9.43 ACHE BCHE PRNP
3 protease binding GO:0002020 9.37 MBP TP53
4 enzyme binding GO:0019899 9.17 BCHE CBS MAPK14 MAPT PPP3CA PRTN3
5 cholinesterase activity GO:0004104 9.16 ACHE BCHE
6 acetylcholinesterase activity GO:0003990 8.96 ACHE BCHE

Sources for Agraphia

3 CDC
7 CNVD
9 Cosmic
10 dbSNP
11 DGIdb
16 ExPASy
18 FMA
28 GO
29 GTR
30 HGMD
31 HMDB
32 HPO
33 ICD10
34 ICD10 via Orphanet
35 ICD9CM
36 IUPHAR
37 KEGG
38 LifeMap
40 MedGen
42 MeSH
43 MESH via Orphanet
44 MGI
46 NCI
47 NCIt
48 NDF-RT
51 NINDS
52 Novoseek
54 OMIM
55 OMIM via Orphanet
59 PubMed
60 QIAGEN
65 SNOMED-CT via HPO
66 SNOMED-CT via Orphanet
67 TGDB
68 Tocris
69 UMLS
70 UMLS via Orphanet
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