Aliases & Classifications for Agraphia

Summaries for Agraphia

Disease Ontology : 12 An acquired writing disorder causing a loss in the ability to communicate through writing, either due to some motor dysfunction or the inability to spell.

MalaCards based summary : Agraphia is related to dysgraphia and gerstmann syndrome, and has symptoms including other symbolic dysfunction An important gene associated with Agraphia is MAPT (Microtubule Associated Protein Tau), and among its related pathways/superpathways are Spinal Cord Injury and Amyotrophic lateral sclerosis (ALS). Affiliated tissues include brain, temporal lobe and occipital lobe, and related phenotypes are Decreased viability with paclitaxel and hematopoietic system

Wikipedia : 71 Agraphia is an acquired neurological disorder causing a loss in the ability to communicate through... more...

Related Diseases for Agraphia

Diseases related to Agraphia via text searches within MalaCards or GeneCards Suite gene sharing:

(show top 50) (show all 81)
id Related Disease Score Top Affiliating Genes
1 dysgraphia 11.0
2 gerstmann syndrome 11.0
3 alexia 10.6
4 protein r deficiency 10.3 GRN MAPT
5 mcleod neuroacanthocytosis syndrome 10.3 MAPT PSEN1
6 gata1-related thrombocytopenia 10.2 GRN MAPT PSEN1
7 hereditary paraganglioma-pheochromocytoma syndromes 10.2 GRN MAPT PSEN1
8 cerebroretinal vasculopathy 10.2 GRN MAPT PSEN1
9 social emotional agnosia 10.2 GRN PSEN1 TARDBP
10 color agnosia 10.2 GRN PSEN1 TARDBP
11 pancreatitis 10.2 GRN PSEN1
12 encephalitozoonosis 10.2 CBS GRN PSEN1
13 hyperglycemia 10.2 CBS GRN PSEN1
14 cerebral arteritis 10.2 PSEN1 TARDBP
15 mitochondrial dna depletion syndrome 3 10.2 GRN MAPT TARDBP
16 meckel syndrome 10 10.1 BCHE MAPT PSEN1
17 spastic ataxia 3 10.1 PPP3CA TP53
18 severe congenital nemaline myopathy 10.1 GRN MAPT PSEN1 TARDBP
19 andersen syndrome 10.1 GRN MAPT PSEN1 TARDBP
20 autoimmune disease of blood 10.1 GRN POU3F3 PSEN1 TARDBP
21 autotopagnosia 10.1 CBS GRN MAPT
22 meier-gorlin syndrome 5 10.1 ACHE CBS GRN MAPT
23 acne inversa, familial, 3 10.1 MAPT MBP PSEN1 TARDBP
24 riedel's fibrosing thyroiditis 10.1 KANTR MAPT TARDBP
25 acquired metabolic disease 10.1 GRN KANTR PSEN1
26 pancreatic cancer/melanoma syndrome 10.1 CBS GRN PSEN1 TARDBP
27 scrotum basal cell carcinoma 10.1 MAPT PRNP
28 mucopolysaccharidosis iv 10.1 GRN MAPT TARDBP
29 central nervous system vasculitis 10.1 KANTR TP53
30 clear cell adenoma 10.1 KANTR MBP PSEN1
31 placental insufficiency 10.0 ACHE BCHE KANTR
32 pancreatic solid pseudopapillary carcinoma 10.0 CBS GRN MAPT PSEN1 TARDBP
33 acute serous otitis media 10.0 KANTR MBP PNMA2
34 ampulla of vater adenosquamous carcinoma 10.0 KANTR MBP PNMA2
35 autoimmune disease of urogenital tract 10.0 GRN MAPT PRNP PSEN1 TARDBP
36 aphasia 9.9
37 adult mesenchymal chondrosarcoma 9.9 ACHE CBS GRN MAPT PSEN1 TARDBP
38 cardiomyopathy, dilated, 1u 9.9 ACHE CBS GRN MAPT PSEN1 TARDBP
39 hallucinogen abuse 9.9 CBS KANTR
40 urethritis 9.9 KANTR MBP PPP3CA PSEN1 TARDBP
41 epithelioid type angiomyolipoma 9.9 ACHE MAPT MBP PRNP PSEN1 TARDBP
42 contagious pustular dermatitis 9.9 ACHE BCHE MAPT MBP PRNP PSEN1
43 long qt syndrome 5 9.8 CBS GRN MAPT PRNP PSEN1 TARDBP
44 cerebritis 9.8
45 dementia 9.8
46 angina pectoris 9.8 CBS GRN KANTR MAPT PSEN1 TARDBP
47 chronic wasting disease 9.8 KANTR PNMA2 PRTN3
48 coenzyme q10 deficiency, primary, 1 9.8 ACHE BCHE GRN MAPT PRNP PSEN1
49 eumycotic mycetoma 9.8 ACHE BCHE GRN MAPT PRNP PSEN1
50 lateral sclerosis 9.7

Graphical network of the top 20 diseases related to Agraphia:



Diseases related to Agraphia

Symptoms & Phenotypes for Agraphia

UMLS symptoms related to Agraphia:


other symbolic dysfunction

GenomeRNAi Phenotypes related to Agraphia according to GeneCards Suite gene sharing:

26
id Description GenomeRNAi Source Accession Score Top Affiliating Genes
1 Decreased viability with paclitaxel GR00293-A 8.92 DEDD PPP3CA PRTN3 TP53

MGI Mouse Phenotypes related to Agraphia:

44 (show all 11)
id Description MGI Source Accession Score Top Affiliating Genes
1 hematopoietic system MP:0005397 10.23 ACHE DEDD GRN MAPK14 MAPT MBP
2 homeostasis/metabolism MP:0005376 10.21 ACHE BCHE GRN MAPK14 MAPT MBP
3 cellular MP:0005384 10.19 GRN MAPK14 MAPT MBP POU3F3 PRNP
4 growth/size/body region MP:0005378 10.18 ACHE DEDD MAPK14 MAPT MBP PPP3CA
5 mortality/aging MP:0010768 10.15 MBP POU3F3 PPP3CA PRNP PSEN1 TARDBP
6 immune system MP:0005387 10.14 DEDD GRN MAPK14 MAPT MBP PPP3CA
7 nervous system MP:0003631 10.03 DEDD GRN MAPK14 MAPT MBP POU3F3
8 muscle MP:0005369 9.92 TARDBP TP53 ACHE MAPK14 MAPT PPP3CA
9 no phenotypic analysis MP:0003012 9.7 ACHE GRN MAPT PRNP PRTN3 TARDBP
10 reproductive system MP:0005389 9.61 ACHE BCHE DEDD GRN MAPK14 MBP
11 vision/eye MP:0005391 9.17 PSEN1 TP53 ACHE GRN MAPT MBP

Drugs & Therapeutics for Agraphia

Interventional clinical trials:


id Name Status NCT ID Phase
1 Effectiveness of a Handwriting Intervention Completed NCT02620098
2 Neurobiology of Language Recovery in Aphasia: Natural History and Treatment-Induced Recovery Recruiting NCT01927302

Search NIH Clinical Center for Agraphia

Genetic Tests for Agraphia

Anatomical Context for Agraphia

MalaCards organs/tissues related to Agraphia:

39
Brain, Temporal Lobe, Occipital Lobe, Testes, Parietal Lobe

Publications for Agraphia

Articles related to Agraphia:

(show top 50) (show all 133)
id Title Authors Year
1
Pure agraphia after infarction in the superior and middle portions of the left precentral gyrus: Dissociation between Kanji and Kana. ( 26597609 )
2016
2
Brain pathology case of the month August 2016 - case 2 A 71 year old man presenting with headache, blurry vision and alexia without agraphia. ( 27647576 )
2016
3
Characteristics of Agraphia in Chinese Patients with Alzheimer's Disease and Amnestic Mild Cognitive Impairment. ( 27364791 )
2016
4
The Ege Agraphia Test Battery for Identifying the Writing Disorders in Cases with Mild Cognitive Impairment and Alzheimer's Disease. ( 27711939 )
2016
5
The nature and treatment of phonological text agraphia. ( 27392251 )
2016
6
Agraphia in Amyotrophic Lateral Sclerosis with Frontotemporal Lobe Degeneration. ( 26905000 )
2016
7
Agraphia in Mobile Text Messages in a Case of Amyotrophic Lateral Sclerosis with Frontotemporal Dementia. ( 26631894 )
2015
8
What letters can "learn" from Arabic digits - fMRI-controlled single case therapy study of peripheral agraphia. ( 26186229 )
2015
9
Apraxic agraphia following thalamic damage: Three new cases. ( 26460984 )
2015
10
Apraxic agraphia following bithalamic damage. ( 25682350 )
2015
11
Treatment for Alexia With Agraphia Following Left Ventral Occipito-Temporal Damage: Strengthening Orthographic Representations Common to Reading and Spelling. ( 26110814 )
2015
12
Alexia Without Agraphia in a Right-Handed Individual Following Right Occipital Stroke. ( 26397830 )
2015
13
Agraphia caused by acute right parietal infarction. ( 25564267 )
2015
14
Reversible cursive agraphia. ( 26195237 )
2015
15
Agraphia in patients with frontotemporal dementia and parkinsonism linked to chromosome 17 with P301L MAPT mutation: dysexecutive, aphasic, apraxic or spatial phenomenon? ( 23121543 )
2014
16
Right Brain: A reading specialist with alexia without agraphia: Teacher interrupted. ( 24379102 )
2014
17
Progressive Wallerian Degeneration of the Corpus Callosal Splenium in a Patient with Alexia Without Agraphia: Advanced MR Findings. ( 25489886 )
2014
18
Posterior cerebral artery stroke presenting as alexia without agraphia. ( 24935413 )
2014
19
Agraphia caused by an infarction in Exner's area. ( 23916761 )
2014
20
Agraphia of Kanji (Chinese characters): an early symptom of sporadic Creutzfeldt-Jakob disease in a Japanese patient: a case report. ( 25098795 )
2014
21
Progressive apraxic agraphia with micrographia presenting as corticobasal syndrome showing extensive Pittsburgh compound B uptake. ( 23589191 )
2013
22
Clinical presentation of left angular gyrus ischaemic lesion: finger agnosia, acalculia, agraphia, left-right disorientation and episodic autoscopia. ( 23813508 )
2013
23
Pure agraphia in Romaji after left inferior frontal gyrus infarction: A case of selective deficit in syllable-to-grapheme conversion in Japanese. ( 23954318 )
2013
24
Agraphia caused by left thalamic hemorrhage. ( 23620716 )
2013
25
Allographic agraphia for single letters. ( 22713390 )
2012
26
Thalamic alexia with agraphia. ( 22593808 )
2012
27
Transient beneficial effects of excitatory theta burst stimulation in a patient with phonological agraphia after left supramarginal gyrus infarction. ( 22296779 )
2012
28
The specificity of notation codes in apraxic agraphia: dissociation between Arabic and alphabetical scripts in a patient with severe ideomotor and visuoconstructional apraxia. ( 20672223 )
2011
29
Temporal lobe epilepsy manifesting as alexia with agraphia for kanji. ( 21907629 )
2011
30
Posterior cortical atrophy with prominent alexia without agraphia in a Tourette syndrome. ( 21912890 )
2011
31
Alexia without agraphia. ( 21675099 )
2011
32
Compensational strategies for a merchant after stroke with anosognosia for alexia without agraphia. ( 20829414 )
2011
33
Damage to the upper portion of area 19 and the deep white matter in the left inferior parietal lobe, including the superior longitudinal fasciculus, results in alexia with agraphia. ( 20798545 )
2010
34
Alexia and agraphia with lesions of the angular and supramarginal gyri: evidence for the disruption of sequential processing. ( 19896678 )
2010
35
A treatment sequence for phonological alexia/agraphia. ( 20360466 )
2010
36
Hanja (Ideogram) alexia and agraphia in patients with semantic dementia. ( 19967597 )
2010
37
Posterior reversible encephalopathy and alexia without agraphia in a patient with Hashimoto's encephalopathy. ( 20119737 )
2010
38
Chapter 37: alexia and agraphia. ( 19892140 )
2010
39
Neologistic jargon aphasia and agraphia in primary progressive aphasia. ( 19033077 )
2009
40
Alexia and agraphia: contrasting perspectives of J.-M. Charcot and J. Hughlings Jackson. ( 18227421 )
2008
41
Alexia with and without agraphia: an assessment of two classical syndromes. ( 19235446 )
2008
42
Alexia without agraphia in Creutzfeldt-Jakob disease. ( 17628601 )
2007
43
Nonconvulsive status epilepticus manifesting as pure alexia (alexia without agraphia). ( 17418645 )
2007
44
Alexia without agraphia in a child with acute disseminated encephalomyelitis. ( 17372144 )
2007
45
Do dual-route models accurately predict reading and spelling performance in individuals with acquired alexia and agraphia? ( 17482218 )
2007
46
Selective alexia and agraphia sparing numbers-a case study. ( 17083972 )
2007
47
Alexia without agraphia in a child with acute disseminated encephalomyelitis. ( 16924040 )
2006
48
Acquired alexia with agraphia syndrome in childhood. ( 16900930 )
2006
49
Magnetic resonance tractography in a patient with alexia without agraphia. ( 16340212 )
2005
50
Alexia without agraphia following cerebral venous thrombosis associated with protein C and protein S deficiency. ( 16311147 )
2005

Variations for Agraphia

Expression for Agraphia

Search GEO for disease gene expression data for Agraphia.

Pathways for Agraphia

Pathways related to Agraphia according to GeneCards Suite gene sharing:

id Super pathways Score Top Affiliating Genes
1 11.62 MBP PPP3CA TP53
2
Show member pathways
11.55 MAPK14 PPP3CA TP53
3 11.53 MAPT MBP PRNP PSEN1 TARDBP
4 11.36 MAPK14 PPP3CA TP53
5 11.1 MAPK14 PPP3CA PSEN1
6 10.86 MAPT PRNP TP53

GO Terms for Agraphia

Cellular components related to Agraphia according to GeneCards Suite gene sharing:

id Name GO ID Score Top Affiliating Genes
1 nucleus GO:0005634 9.44 ACHE CBS DEDD MAPK14 MAPT MBP

Biological processes related to Agraphia according to GeneCards Suite gene sharing:

id Name GO ID Score Top Affiliating Genes
1 positive regulation of gene expression GO:0010628 9.62 MAPK14 POU3F3 PPP3CA TP53
2 3-UTR-mediated mRNA stabilization GO:0070935 9.26 MAPK14 TARDBP
3 amyloid precursor protein metabolic process GO:0042982 9.16 ACHE PSEN1
4 negative regulation of protein phosphorylation GO:0001933 9.13 PRNP PSEN1 TARDBP
5 cellular response to drug GO:0035690 8.8 PPP3CA PRNP TP53

Molecular functions related to Agraphia according to GeneCards Suite gene sharing:

id Name GO ID Score Top Affiliating Genes
1 identical protein binding GO:0042802 9.8 BCHE CBS MAPT PRNP TARDBP TP53
2 beta-amyloid binding GO:0001540 9.43 ACHE BCHE PRNP
3 enzyme binding GO:0019899 9.17 BCHE CBS MAPK14 MAPT PPP3CA PRTN3
4 cholinesterase activity GO:0004104 9.16 ACHE BCHE
5 acetylcholinesterase activity GO:0003990 8.96 ACHE BCHE

Sources for Agraphia

3 CDC
7 CNVD
9 Cosmic
10 dbSNP
11 DGIdb
16 ExPASy
18 FMA
28 GO
29 GTR
30 HGMD
31 HMDB
32 HPO
33 ICD10
34 ICD10 via Orphanet
35 ICD9CM
36 IUPHAR
37 KEGG
38 LifeMap
40 MedGen
42 MeSH
43 MESH via Orphanet
44 MGI
46 NCI
47 NCIt
48 NDF-RT
51 NINDS
52 Novoseek
54 OMIM
55 OMIM via Orphanet
59 PubMed
60 QIAGEN
65 SNOMED-CT via Orphanet
67 TGDB
68 Tocris
69 UMLS
70 UMLS via Orphanet
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