Aliases & Classifications for Agraphia

Summaries for Agraphia

Disease Ontology : 12 An acquired writing disorder causing a loss in the ability to communicate through writing, either due to some motor dysfunction or the inability to spell.

MalaCards based summary : Agraphia is related to alexia and aphasia, and has symptoms including other symbolic dysfunction An important gene associated with Agraphia is MAPT (Microtubule Associated Protein Tau), and among its related pathways/superpathways are Spinal Cord Injury and Amyotrophic lateral sclerosis (ALS). Affiliated tissues include brain, temporal lobe and occipital lobe, and related phenotypes are Decreased viability with paclitaxel and hematopoietic system

Wikipedia : 72 Agraphia is an acquired neurological disorder causing a loss in the ability to communicate through... more...

Related Diseases for Agraphia

Diseases related to Agraphia via text searches within MalaCards or GeneCards Suite gene sharing:

(show top 50) (show all 80)
# Related Disease Score Top Affiliating Genes
1 alexia 30.7 KANTR MBP PPP3CA PSEN1 TARDBP
2 aphasia 30.3 GRN MAPT PRNP PSEN1
3 frontotemporal lobar degeneration with tdp43 inclusions, grn-related 30.2 GRN MAPT
4 writing disorder 30.1 GRN PSEN1
5 semantic dementia 30.1 GRN MAPT TARDBP
6 prosopagnosia 30.0 GRN PSEN1
7 dementia 29.6 ACHE GRN MAPT PRNP PSEN1 TARDBP
8 frontotemporal dementia 29.1 ACHE BCHE GRN MAPT PRNP PSEN1
9 amyotrophic lateral sclerosis 1 29.0 CDR1 GRN MAPT PRNP PSEN1 TARDBP
10 alzheimer disease 28.9 ACHE BCHE GRN MAPT PPP3CA PRNP
11 gerstmann syndrome 11.2
12 dysgraphia 11.1
13 inclusion body myopathy with early-onset paget disease and frontotemporal dementia 10.9
14 progressive non-fluent aphasia 10.4 GRN MAPT PSEN1
15 behavioral variant of frontotemporal dementia 10.4 GRN MAPT PSEN1
16 phonagnosia 10.4 GRN PSEN1 TARDBP
17 associative agnosia 10.4 GRN PSEN1 TARDBP
18 expressive language disorder 10.4 PSEN1 TARDBP
19 gait apraxia 10.3 CBS GRN PSEN1
20 disease of mental health 10.3 GRN MAPT PSEN1
21 alzheimer disease 2 10.2 BCHE MAPT PSEN1
22 akinetic mutism 10.2 MAPT PRNP
23 pick disease of brain 10.2 GRN MAPT PSEN1 TARDBP
24 familial idiopathic basal ganglia calcification 10.2 MAPT PSEN1
25 echolalia 10.2 CBS GRN MAPT PSEN1
26 cerebral amyloid angiopathy, cst3-related 10.2 MAPT PRNP PSEN1
27 frontotemporal dementia and/or amyotrophic lateral sclerosis 1 10.2 CBS GRN PSEN1 TARDBP
28 cicatricial ectropion 10.2 CBS KANTR
29 glomangiosarcoma 10.1 KANTR TP53
30 postencephalitic parkinson disease 10.1 KANTR MAPT TARDBP
31 visual agnosia 10.1 GRN KANTR PSEN1
32 internuclear ophthalmoplegia 10.1 KANTR MBP PSEN1
33 colonic pseudo-obstruction 10.0 ACHE BCHE KANTR
34 basal ganglia disease 10.0 CBS GRN MAPT PSEN1 TARDBP
35 transient global amnesia 10.0 KANTR PRNP PSEN1
36 oculomotor nerve paralysis 10.0 KANTR MBP PNMA2
37 third cranial nerve disease 10.0 KANTR MBP PNMA2
38 multiple sclerosis 9.9
39 cerebritis 9.9
40 auditory agnosia 9.9 KANTR PRNP
41 nominal aphasia 9.9 ACHE CBS GRN MAPT PSEN1 TARDBP
42 supranuclear palsy, progressive, 1 9.9 ACHE CBS GRN MAPT PSEN1 TARDBP
43 creutzfeldt-jakob disease 9.8
44 lateral sclerosis 9.8
45 agnosia 9.8
46 acute disseminated encephalomyelitis 9.8
47 encephalitis 9.8
48 marchiafava bignami disease 9.8
49 posterior cortical atrophy 9.8
50 central nervous system disease 9.8 ACHE MAPT MBP PRNP PSEN1 TARDBP

Graphical network of the top 20 diseases related to Agraphia:



Diseases related to Agraphia

Symptoms & Phenotypes for Agraphia

UMLS symptoms related to Agraphia:


other symbolic dysfunction

GenomeRNAi Phenotypes related to Agraphia according to GeneCards Suite gene sharing:

25
# Description GenomeRNAi Source Accession Score Top Affiliating Genes
1 Decreased viability with paclitaxel GR00293-A 8.92 DEDD PPP3CA PRTN3 TP53

MGI Mouse Phenotypes related to Agraphia:

43
# Description MGI Source Accession Score Top Affiliating Genes
1 hematopoietic system MP:0005397 10.21 ACHE DEDD GRN MAPK14 MAPT MBP
2 homeostasis/metabolism MP:0005376 10.18 ACHE BCHE GRN MAPK14 MAPT MBP
3 immune system MP:0005387 10.11 TP53 DEDD GRN MAPK14 MAPT MBP
4 mortality/aging MP:0010768 10.1 MAPK14 MAPT MBP POU3F3 PPP3CA PRNP
5 nervous system MP:0003631 9.93 GRN MAPK14 MAPT MBP POU3F3 PPP3CA
6 muscle MP:0005369 9.86 ACHE MAPK14 MAPT PPP3CA PRNP PSEN1
7 no phenotypic analysis MP:0003012 9.5 ACHE GRN MAPT PRNP PRTN3 TARDBP
8 reproductive system MP:0005389 9.28 ACHE BCHE DEDD GRN MAPK14 MBP

Drugs & Therapeutics for Agraphia

Interventional clinical trials:


# Name Status NCT ID Phase Drugs
1 Effectiveness of a Handwriting Intervention Completed NCT02620098
2 Neurobiology of Language Recovery in Aphasia: Natural History and Treatment-Induced Recovery Active, not recruiting NCT01927302

Search NIH Clinical Center for Agraphia

Genetic Tests for Agraphia

Anatomical Context for Agraphia

MalaCards organs/tissues related to Agraphia:

38
Brain, Temporal Lobe, Occipital Lobe, Parietal Lobe, Testes

Publications for Agraphia

Articles related to Agraphia:

(show top 50) (show all 141)
# Title Authors Year
1
Maximising recovery from aphasia with central and peripheral agraphia: The benefit of sequential treatments. ( 29298550 )
2018
2
Agraphia of the left hand with dysfunction of the left superior parietal region without callosal lesions. ( 29430524 )
2018
3
The neural substrates of improved phonological processing following successful treatment in a case of phonological alexia and agraphia. ( 29350575 )
2018
4
Agraphia manifesting during a WhatsApp conversation. ( 29169804 )
2017
5
Multi-step treatment for acquired alexia and agraphia (part II): a dual-route error scoring system. ( 28421910 )
2017
6
A Case of Anoxic Brain Injury Presenting with Agraphia of kanji in the Foreground. ( 28611641 )
2017
7
Alexia Without Agraphia: A Rare Entity. ( 28690938 )
2017
8
Multi-step treatment for acquired alexia and agraphia (Part I): efficacy, generalisation, and identification of beneficial treatment steps. ( 28421858 )
2017
9
Brain pathology case of the month August 2016 - case 2 A 71 year old man presenting with headache, blurry vision and alexia without agraphia. ( 27647576 )
2016
10
The Ege Agraphia Test Battery for Identifying the Writing Disorders in Cases with Mild Cognitive Impairment and Alzheimer's Disease. ( 27711939 )
2016
11
Agraphia in Amyotrophic Lateral Sclerosis with Frontotemporal Lobe Degeneration. ( 26905000 )
2016
12
Pure agraphia after infarction in the superior and middle portions of the left precentral gyrus: Dissociation between Kanji and Kana. ( 26597609 )
2016
13
Characteristics of Agraphia in Chinese Patients with Alzheimer's Disease and Amnestic Mild Cognitive Impairment. ( 27364791 )
2016
14
The nature and treatment of phonological text agraphia. ( 27392251 )
2016
15
Agraphia caused by acute right parietal infarction. ( 25564267 )
2015
16
Treatment for Alexia With Agraphia Following Left Ventral Occipito-Temporal Damage: Strengthening Orthographic Representations Common to Reading and Spelling. ( 26110814 )
2015
17
Alexia Without Agraphia in a Right-Handed Individual Following Right Occipital Stroke. ( 26397830 )
2015
18
Agraphia in Mobile Text Messages in a Case of Amyotrophic Lateral Sclerosis with Frontotemporal Dementia. ( 26631894 )
2015
19
Apraxic agraphia following thalamic damage: Three new cases. ( 26460984 )
2015
20
Apraxic agraphia following bithalamic damage. ( 25682350 )
2015
21
Reversible cursive agraphia. ( 26195237 )
2015
22
What letters can "learn" from Arabic digits - fMRI-controlled single case therapy study of peripheral agraphia. ( 26186229 )
2015
23
Progressive Wallerian Degeneration of the Corpus Callosal Splenium in a Patient with Alexia Without Agraphia: Advanced MR Findings. ( 25489886 )
2014
24
Agraphia caused by an infarction in Exner's area. ( 23916761 )
2014
25
Agraphia in patients with frontotemporal dementia and parkinsonism linked to chromosome 17 with P301L MAPT mutation: dysexecutive, aphasic, apraxic or spatial phenomenon? ( 23121543 )
2014
26
Right Brain: A reading specialist with alexia without agraphia: Teacher interrupted. ( 24379102 )
2014
27
Posterior cerebral artery stroke presenting as alexia without agraphia. ( 24935413 )
2014
28
Agraphia of Kanji (Chinese characters): an early symptom of sporadic Creutzfeldt-Jakob disease in a Japanese patient: a case report. ( 25098795 )
2014
29
Progressive apraxic agraphia with micrographia presenting as corticobasal syndrome showing extensive Pittsburgh compound B uptake. ( 23589191 )
2013
30
Agraphia caused by left thalamic hemorrhage. ( 23620716 )
2013
31
Pure agraphia in Romaji after left inferior frontal gyrus infarction: A case of selective deficit in syllable-to-grapheme conversion in Japanese. ( 23954318 )
2013
32
Clinical presentation of left angular gyrus ischaemic lesion: finger agnosia, acalculia, agraphia, left-right disorientation and episodic autoscopia. ( 23813508 )
2013
33
Transient beneficial effects of excitatory theta burst stimulation in a patient with phonological agraphia after left supramarginal gyrus infarction. ( 22296779 )
2012
34
Allographic agraphia for single letters. ( 22713390 )
2012
35
Thalamic alexia with agraphia. ( 22593808 )
2012
36
Compensational strategies for a merchant after stroke with anosognosia for alexia without agraphia. ( 20829414 )
2011
37
Alexia without agraphia. ( 21675099 )
2011
38
The specificity of notation codes in apraxic agraphia: dissociation between Arabic and alphabetical scripts in a patient with severe ideomotor and visuoconstructional apraxia. ( 20672223 )
2011
39
Posterior cortical atrophy with prominent alexia without agraphia in a Tourette syndrome. ( 21912890 )
2011
40
Temporal lobe epilepsy manifesting as alexia with agraphia for kanji. ( 21907629 )
2011
41
Alexia and agraphia with lesions of the angular and supramarginal gyri: evidence for the disruption of sequential processing. ( 19896678 )
2010
42
A treatment sequence for phonological alexia/agraphia. ( 20360466 )
2010
43
Damage to the upper portion of area 19 and the deep white matter in the left inferior parietal lobe, including the superior longitudinal fasciculus, results in alexia with agraphia. ( 20798545 )
2010
44
Posterior reversible encephalopathy and alexia without agraphia in a patient with Hashimoto's encephalopathy. ( 20119737 )
2010
45
Hanja (Ideogram) alexia and agraphia in patients with semantic dementia. ( 19967597 )
2010
46
Chapter 37: alexia and agraphia. ( 19892140 )
2010
47
Neologistic jargon aphasia and agraphia in primary progressive aphasia. ( 19033077 )
2009
48
Alexia with and without agraphia: an assessment of two classical syndromes. ( 19235446 )
2008
49
Alexia and agraphia: contrasting perspectives of J.-M. Charcot and J. Hughlings Jackson. ( 18227421 )
2008
50
Selective alexia and agraphia sparing numbers-a case study. ( 17083972 )
2007

Variations for Agraphia

Expression for Agraphia

Search GEO for disease gene expression data for Agraphia.

Pathways for Agraphia

Pathways related to Agraphia according to GeneCards Suite gene sharing:

# Super pathways Score Top Affiliating Genes
1 11.62 MBP PPP3CA TP53
2
Show member pathways
11.55 MAPK14 PPP3CA TP53
3 11.55 MAPT MBP PRNP PSEN1 TARDBP
4 11.33 MAPK14 PPP3CA TP53
5 11.07 MAPK14 PPP3CA PSEN1
6 10.86 MAPT PRNP TP53

GO Terms for Agraphia

Biological processes related to Agraphia according to GeneCards Suite gene sharing:

# Name GO ID Score Top Affiliating Genes
1 negative regulation of protein phosphorylation GO:0001933 9.5 PRNP PSEN1 TARDBP
2 cellular response to drug GO:0035690 9.43 PPP3CA PRNP TP53
3 3-UTR-mediated mRNA stabilization GO:0070935 9.4 MAPK14 TARDBP
4 amyloid precursor protein metabolic process GO:0042982 9.37 ACHE PSEN1
5 astrocyte activation GO:0048143 9.16 MAPT PSEN1
6 modulation of age-related behavioral decline GO:0090647 8.96 PRNP PSEN1
7 neuron projection maintenance GO:1990535 8.62 PRNP PSEN1

Molecular functions related to Agraphia according to GeneCards Suite gene sharing:

# Name GO ID Score Top Affiliating Genes
1 identical protein binding GO:0042802 9.88 BCHE CBS MAPT PRNP TARDBP TP53
2 protease binding GO:0002020 9.5 MBP PRNP TP53
3 amyloid-beta binding GO:0001540 9.43 ACHE BCHE PRNP
4 enzyme binding GO:0019899 9.17 BCHE CBS MAPK14 MAPT PPP3CA PRTN3
5 cholinesterase activity GO:0004104 9.16 ACHE BCHE
6 acetylcholinesterase activity GO:0003990 8.96 ACHE BCHE
7 protein binding GO:0005515 10.27 ACHE CBS CDR1 DEDD GRN MAPK14

Sources for Agraphia

3 CDC
7 CNVD
9 Cosmic
10 dbSNP
11 DGIdb
16 ExPASy
18 FMA
27 GO
28 GTR
29 HGMD
30 HMDB
31 HPO
32 ICD10
33 ICD10 via Orphanet
34 ICD9CM
35 IUPHAR
36 KEGG
37 LifeMap
39 MedGen
41 MeSH
42 MESH via Orphanet
43 MGI
45 NCI
46 NCIt
47 NDF-RT
50 NINDS
51 Novoseek
53 OMIM
54 OMIM via Orphanet
58 PubMed
60 QIAGEN
65 SNOMED-CT via HPO
66 SNOMED-CT via Orphanet
67 TGDB
68 Tocris
69 UMLS
70 UMLS via Orphanet
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