ADC
MCID: ADS004
MIFTS: 40

Aids Dementia Complex (ADC) malady

Rare diseases, Mental diseases categories

Summaries for Aids Dementia Complex

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66Wikipedia, 34MalaCards
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Wikipedia:66 HIV-associated neurocognitive disorder (HAND) is a common umbrella term for neurological disorders... more...

MalaCards: Aids Dementia Complex, also known as aids related cognitive impairment, is related to dementia and kaposi's sarcoma. An important gene associated with Aids Dementia Complex is ITIH4 (inter-alpha-trypsin inhibitor heavy chain family, member 4). The compounds dizocilpine and memantine have been mentioned in the context of this disorder. Affiliated tissues include monocytes, brain and testes, and related mouse phenotypes are liver/biliary system and cellular.

Aliases & Classifications for Aids Dementia Complex

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44NIH Rare Diseases, 46Novoseek, 63UMLS
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Classifications:

Malacards categories (disease lists): (See all malacards categories)
Global: Rare diseases
Anatomical: Mental diseases


Aliases & Descriptions:

aids dementia complex 44 46 63
aids related cognitive impairment 44
adc 44


Related Diseases for Aids Dementia Complex

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18GeneCards, 19GeneDecks
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Graphical network of the top 20 diseases related to Aids Dementia Complex:



Diseases related to aids dementia complex

Symptoms for Aids Dementia Complex

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Drugs & Therapeutics for Aids Dementia Complex

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Sources:
6CenterWatch, 43NIH Clinical Center, 7ClinicalTrials, 63UMLS, 42NDF-RT
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Approved drugs:

Search CenterWatch for Aids Dementia Complex

Drug clinical trials:

Search ClinicalTrials for Aids Dementia Complex

Search NIH Clinical Center for Aids Dementia Complex

Search CenterWatch for Aids Dementia Complex

Genetic Tests for Aids Dementia Complex

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Anatomical Context for Aids Dementia Complex

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34MalaCards
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MalaCards organs/tissues related to Aids Dementia Complex:

34
Monocytes, Brain, Testes, T cells, Cortex

Animal Models for Aids Dementia Complex or affiliated genes

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38MGI
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MGI Mouse Phenotypes related to Aids Dementia Complex:

38
idDescriptionMGI Source AccessionScoreTop Affiliating Genes
1MP:00053708.7PLAUR, ITIH4, B2M
2MP:00053847.9PLAUR, ITIH4, CCR3, B2M

Publications for Aids Dementia Complex

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53PubMed
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Articles related to Aids Dementia Complex:

(show top 50)    (show all 184)
idTitleAuthorsYear
1
Memantine for AIDS dementia complex: open-label report of ACTG 301. (20400412)
2010
2
Validity of the CogState brief battery: relationship to standardized tests and sensitivity to cognitive impairment in mild traumatic brain injury, schizophrenia, and AIDS dementia complex. (19395350)
2009
3
High level HIV-1 DNA concentrations in brain tissues differentiate patients with post-HAART AIDS dementia complex or cardiovascular disease from those with AIDS. (19641870)
2009
4
Communication impairment in the AIDS dementia complex (ADC): a case report. (18242630)
2008
5
Prevalence of AIDS dementia complex: results from a statewide population-based registry of Alzheimer's disease and related disorders. (19058735)
2008
6
AIDS dementia complex in China. (17070055)
2007
7
Cerebrospinal fluid markers in central nervous system HIV infection and AIDS dementia complex. (18808988)
2007
8
AIDS dementia complex and Hashimoto encephalopathy in a senescent woman. (18033678)
2007
9
AIDS dementia complex. (16909695)
2006
10
Inflammation and neuroaxonal injury in multiple sclerosis and AIDS dementia complex: implications for neuroprotective treatment. (16138246)
2005
11
The AIDS dementia complex: clinical and basic neuroscience with implications for novel molecular therapies. (16260383)
2005
12
Involvement of quinolinic acid in AIDS dementia complex. (15639803)
2005
13
A multi-center 1H MRS study of the AIDS dementia complex: validation and preliminary analysis. (12766890)
2003
14
Elevated levels of soluble Fas and Fas ligand in cerebrospinal fluid of patients with AIDS dementia complex. (11240032)
2001
15
Human Herpesvirus 8 and Protection from AIDS Dementia Complex. (11867000)
2000
16
AIDS dementia complex. (10517932)
1999
17
Anomalies in Nef expression within the central nervous system of HIV-1 positive individuals/AIDS patients with or without AIDS dementia complex. (9639072)
1998
18
Pathogenic mechanisms of neuronal damage in the AIDS dementia complex. (9231153)
1997
19
The neuropathogenesis of the AIDS dementia complex. (9451964)
1997
20
The relationship between AIDS dementia complex and the presence of macrophage tropic and non-syncytium inducing isolates of human immunodeficiency virus type 1 in the cerebrospinal fluid. (8799207)
1996
21
The cellular basis of central nervous system HIV-1 infection and the AIDS dementia complex: introduction. (16873153)
1996
22
Genetic and biological analysis of variants derived from the cerebrospinal fluid of HIV type 1 subtype B- and D- infected patients with and without AIDS dementia complex. (8947301)
1996
23
Epidemiology of AIDS dementia complex in Europe. AIDS in Europe Study Group. (8528731)
1996
24
Cellular basis of HIV infection of the CNS and the AIDS dementia complex: oligodendrocyte. (16873159)
1996
25
AIDS dementia complex: incidence, clinical profile and impact of zidovudine treatment*. (21284769)
1996
26
Astrocytes and the AIDS dementia complex. (16873158)
1996
27
Review of antiretroviral therapy in the prevention of HIV-related AIDS dementia complex (ADC). (7614899)
1995
28
Trypsin inhibition: a potential cause of cobalamin deficiency common to the pathogenesis of Alzheimer-type dementia and AIDS dementia complex? (8531843)
1995
29
More acquired immunodeficiency syndrome (AIDS) dementia complex in Japan? (8563090)
1995
30
Management of AIDS dementia complex and HIV-1 infection of the nervous system. (8819589)
1995
31
The role of the consultation-liaison nurse. Caring for patients with AIDS dementia complex. (8667308)
1995
32
Neuropsychological characterization of the AIDS dementia complex and rationalization of a test battery. (8018042)
1994
33
Cerebrospinal fluid HIV-1 p24 antigen and culture: sensitivity and specificity for AIDS-dementia complex. (8021661)
1994
34
SPECT imaging of the brain: comparison of findings in patients with chronic fatigue syndrome, AIDS dementia complex, and major unipolar depression. (8141022)
1994
35
Zidovudine treatment of the AIDS dementia complex: results of a placebo-controlled trial. AIDS Clinical Trials Group. (8489204)
1993
36
Cerebrospinal fluid beta 2-microglobulin in patients with AIDS dementia complex: an expanded series including response to zidovudine treatment. (1616651)
1992
37
Cerebrospinal fluid myelin basic protein in AIDS dementia complex: relationship to disease progression and zidovudine treatment. (1281644)
1992
38
Proton MR spectroscopy of the brain in AIDS dementia complex. (1629410)
1992
39
Single photon emission computed tomography with 99mTc-HMPAO in HIV-1 infection: a help in early diagnosis of AIDS dementia complex. (1927637)
1991
40
Detection of cerebrospinal fluid antibodies against myelin basic protein in patients with AIDS dementia complex. (1720316)
1991
41
Aids dementia complex. On the relationship between HIV-1 infection, immune-mediated response and myelin damage in the brain. (1891984)
1991
42
Early HIV-1 infection and the AIDS dementia complex. (2300258)
1990
43
AIDS dementia complex: brain high-energy phosphate metabolite deficits. (2367655)
1990
44
The significant other's role in improving quality of life in persons with AIDS dementia complex. (2527929)
1989
45
Declining incidence of AIDS dementia complex after introduction of zidovudine treatment. (2510843)
1989
46
Tumor necrosis factor alpha (TNF alpha) and neurological diseases. Failure in detecting TNF alpha in the cerebrospinal fluid from patients with multiple sclerosis, AIDS dementia complex, and brain tumours. (2723041)
1989
47
AIDS-dementia-complex: pathology, pathogenesis and future directions. (2670816)
1989
48
Neuropsychiatric aspects of AIDS dementia complex: a report on a clinical series. (3200506)
1988
49
The brain in AIDS: central nervous system HIV-1 infection and AIDS dementia complex. (3277272)
1988
50
HIV antigen in the brains of patients with the AIDS dementia complex. (3296948)
1987

Variations for Aids Dementia Complex

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Expression for genes affiliated with Aids Dementia Complex

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Sources:
2BioGPS, 16Gene Expression Omnibus DataSets
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Expression patterns in normal tissues for genes affiliated with Aids Dementia Complex

Search GEO for disease gene expression data for Aids Dementia Complex.

Pathways for genes affiliated with Aids Dementia Complex

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Compounds for genes affiliated with Aids Dementia Complex

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Sources:
46Novoseek, 30IUPHAR, 52PharmGKB, 12DrugBank, 62Tocris Bioscience, 25HMDB, 3BitterDB
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Compounds related to Aids Dementia Complex according to GeneCards/GeneDecks:

(show top 50)    (show all 59)
idCompoundScoreTop Affiliating Genes
1dizocilpine469.8ITIH4, TAT
2memantine46 30 52 1212.8ITIH4, TAT
32,5-oligoadenylate469.7TAT, B2M
4ccl346 3010.7TAT, CCR3
5corticosterone46 62 2511.6TAT, ITIH4
6asparagine469.6TAT, ITIH4
7urea46 25 1211.6ITIH4, B2M
8nifedipine46 30 52 1212.6ITIH4, B2M
9glycolipid469.5PLAUR, ITIH4
10amiloride46 30 1211.5PLAUR, ITIH4
11lead469.5B2M, TAT
12aprotinin46 1210.5ITIH4, PLAUR
13vincristine46 52 1211.5TAT, B2M
14neopterin469.4PLAUR, B2M
15uric acid46 2510.4B2M, PLAUR
16suramin46 30 1211.4PLAUR, ITIH4
17cocaine46 1210.4ITIH4, TAT
18inositol469.4TAT, ITIH4
19opiate469.3TAT, ITIH4, CCR3
20chloroquine46 3 52 30 1213.3B2M, ITIH4, TAT
21zidovudine46 52 1211.3TAT, ITIH4, B2M
22vitamin-e469.3TAT, ITIH4, B2M
23morphine46 52 30 1212.3TAT, ITIH4, CCR3
24rantes469.3TAT, ITIH4, CCR3
25cyclosporin a46 30 6211.3TAT, ITIH4, B2M
26lactate469.2B2M, ITIH4, TAT
27aspartate469.2TAT, ITIH4, B2M
28adenylate469.2CCR3, ITIH4, TAT
29biotin46 25 1211.1PLAUR, ITIH4, B2M
30paraffin469.1PLAUR, ITIH4, B2M
31pge2469.1PLAUR, ITIH4, B2M
32thymidine46 2510.0PLAUR, CCR3, B2M
33iron46 259.9B2M, PLAUR, TAT
34arginine468.8ITIH4, PLAUR, TAT
35dexamethasone46 52 30 1211.8TAT, PLAUR, CCR3
36vegf468.8TAT, PLAUR, B2M
37indomethacin46 30 62 1211.5B2M, ITIH4, PLAUR, TAT
38actinomycin d468.5CCR3, ITIH4, PLAUR, TAT
39glutamine468.5B2M, ITIH4, PLAUR, TAT
40heparin46 30 25 1211.5CCR3, ITIH4, PLAUR, TAT
41cycloheximide468.5B2M, ITIH4, PLAUR, TAT
42butyrate468.4TAT, PLAUR, CCR3, B2M
43serine468.4TAT, PLAUR, ITIH4, B2M
44genistein46 30 62 3 25 1213.4TAT, PLAUR, CCR3, B2M
45oxygen46 259.4TAT, PLAUR, CCR3
46tyrosine468.4CCR3, ITIH4, PLAUR, TAT
47retinoic acid46 259.4TAT, PLAUR, CCR3, B2M
48estrogen468.2TAT, PLAUR, B2M
49alanine468.0TAT, PLAUR, ITIH4, CCR3, B2M
50cysteine468.0B2M, CCR3, ITIH4, PLAUR, TAT

GO Terms for genes affiliated with Aids Dementia Complex

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17Gene Ontology
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Cellular components related to Aids Dementia Complex according to GeneCards/GeneDecks:

idNameGO IDScoreTop Affiliating Genes
1endoplasmic reticulum lumenGO:0057889.1PLAUR, B2M

Biological processes related to Aids Dementia Complex according to GeneCards/GeneDecks:

idNameGO IDScoreTop Affiliating Genes
1chemotaxisGO:0069359.1PLAUR, CCR3

Products for genes affiliated with Aids Dementia Complex

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  • Antibodies
  • Proteins
  • Lysates
  • Antibodies

Sources for Aids Dementia Complex

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4CDC
14ExPASy
15FMA
23GTR
24HGMD
25HMDB
26ICD10
27ICD10 via Orphanet
28ICD9CM
30IUPHAR
31KEGG
36MeSH
37MESH via Orphanet
38MGI
41NCIt
42NDF-RT
45NINDS
46Novoseek
48OMIM
49OMIM via Orphanet
53PubMed
54QIAGEN
60SNOMED-CT via Orphanet
63UMLS
64UMLS via Orphanet