ADC
MCID: ADS004
MIFTS: 47

Aids Dementia Complex (ADC) malady

Summaries for Aids Dementia Complex

Sources:
64Wikipedia, 33MalaCards
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Wikipedia:64 HIV-associated neurocognitive disorder (HAND) is a common umbrella term for neurological disorders... more...

MalaCards: Aids Dementia Complex, also known as aids related cognitive impairment, is related to kaposi's sarcoma and brain disease. An important gene associated with Aids Dementia Complex is ITIH4 (inter-alpha-trypsin inhibitor heavy chain family, member 4), and among its related pathways are Leishmaniasis and Monoamine Transport. The compounds pge2 and cycloheximide have been mentioned in the context of this disorder. Affiliated tissues include brain, cortex and monocytes, and related mouse phenotypes are reproductive system and tumorigenesis.

Aliases & Classifications for Aids Dementia Complex

Sources:
43NIH Rare Diseases, 45Novoseek, 61UMLS
See all sources

Aliases & Descriptions:

aids dementia complex 43 45 61
aids related cognitive impairment 43
adc 43


Related Diseases for Aids Dementia Complex

Sources:
17GeneCards, 18GeneDecks
See all sources

Diseases related to Aids Dementia Complex via text searches within MalaCards or GeneCards/GeneDecks gene sharing:

(show top 50)    (show all 205)
idRelated DiseaseScoreTop Affiliating Genes
1kaposi's sarcoma30.6TAT
2brain disease30.4TAT, ITIH4, MBP
3acquired immunodeficiency syndrome30.4TAT, IL1B, CXCL12, B2M, CCR3, CCR5
4cocaine abuse30.2SLC6A3
5alzheimer's disease30.2BDNF, CCR3, ITIH4, CXCL12, IL1B, PLAUR
6hepatitis c30.1CCR5, MBP, CXCL12
7hypoglycemia29.9BDNF
8chronic fatigue syndrome10.1
9toxoplasmosis10.1
10neurologic diseases10.1
11brain injury10.1
12cerebral atrophy10.1
13dementia - subcortical10.1
14myoclonus10.1
15traumatic brain injury10.1
16normal pressure hydrocephalus10.1
17hyperargininemia10.1
18neuronitis10.1
19hepatitis d10.1
20viral hepatitis10.1
21spinal cord injury10.1
22solitary fibrous tumor10.1
23macroglobulinemia10.0B2M
24liver cirrhosis10.0TAT
25atopy10.0CCR3
26sjogren's syndrome10.0B2M
27sarcoma10.0TAT
28esophagitis10.0CCR3
29chagas disease10.0CCR5
30allergic rhinitis10.0CCR3
31thrombocytopenia10.0CXCR4
32neuroblastoma10.0BDNF
33wilson disease10.0SLC6A3
34disseminated intravascular coagulation10.0TAT
35neuropathy10.0MBP
36essential hypertension10.0CCR5
37neuritis10.0MBP
38optic neuritis10.0MBP
39pemphigus10.0PLAUR
40gingivitis10.0IL1B
41chronic myeloproliferative disease10.0B2M
42myelofibrosis10.0CXCL12
43meningitis10.0IL1B
44wegener's granulomatosis10.0CCR5
45graves' disease10.0CCR5
46hypercholesterolemia10.0NOS2
47polyneuropathy10.0MBP
48crohn's disease10.0TNF
49amphetamine abuse10.0SLC6A3
50lyme disease10.0MBP

Graphical network of the top 20 diseases related to Aids Dementia Complex:



Diseases related to aids dementia complex

Clinical Features for Aids Dementia Complex

Drugs & Therapeutics for Aids Dementia Complex

Sources:
5CenterWatch, 42NIH Clinical Center, 6ClinicalTrials, 61UMLS, 41NDF-RT
See all sources

Approved drugs:

Search CenterWatch for Aids Dementia Complex

Drug clinical trials:

Search ClinicalTrials for Aids Dementia Complex

Search NIH Clinical Center for Aids Dementia Complex

Search CenterWatch for Aids Dementia Complex

Genetic Tests for Aids Dementia Complex

Anatomical Context for Aids Dementia Complex

Sources:
33MalaCards
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MalaCards organs/tissues related to Aids Dementia Complex:

33
Brain, Cortex, Monocytes, T cells, B cells, Temporal lobe

Animal Models for Aids Dementia Complex or affiliated genes

Sources:
37MGI, 28inGenious Targeting Laboratory
See all sources

Publications for Aids Dementia Complex

Sources:
51PubMed
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Articles related to Aids Dementia Complex:

(show top 50)    (show all 186)
idTitleAuthorsYear
1
Validity of the CogState brief battery: relationship to standardized tests and sensitivity to cognitive impairment in mild traumatic brain injury, schizophrenia, and AIDS dementia complex. (19395350)
2009
2
Analysis of genetic diversity and biological functional site of HIV-1 gp120 from a patient with AIDS dementia complex]. (19634757)
2009
3
Prevalence of AIDS dementia complex: results from a statewide population-based registry of Alzheimer's disease and related disorders. (19058735)
2008
4
Adjunctive therapies for AIDS dementia complex. (18646159)
2008
5
AIDS dementia complex in China. (17070055)
2007
6
Proton MRS and neuropsychological correlates in AIDS dementia complex: evidence of subcortical specificity. (17827413)
2007
7
Timed Gait test: normative data for the assessment of the AIDS dementia complex. (16840235)
2006
8
Editorial comment: AIDS dementia complex in the current era. (17152650)
2006
9
Inflammation and neuroaxonal injury in multiple sclerosis and AIDS dementia complex: implications for neuroprotective treatment. (16138246)
2005
10
The AIDS dementia complex: clinical and basic neuroscience with implications for novel molecular therapies. (16260383)
2005
11
HAART & the molecular biology of AIDS dementia complex. (15817943)
2005
12
Screening for the AIDS dementia complex. (11862659)
2002
13
Involvement of dopamine in the progression of AIDS Dementia Complex. (11956960)
2002
14
Kaposi's sarcoma and human herpesvirus 8 infection do not protect HIV-1 infected homosexual men from AIDS dementia complex. (11684936)
2001
15
Human Herpesvirus 8 and Protection from AIDS Dementia Complex. (11867000)
2000
16
Reduced prevalence of the CCR5 delta32 heterozygous genotype in human immunodeficiency virus-infected individuals with AIDS dementia complex. (10438379)
1999
17
Increased peroxynitrite activity in AIDS dementia complex: implications for the neuropathogenesis of HIV-1 infection. (10201964)
1999
18
AIDS dementia complex: response to highly active antiretroviral therapy. (10597800)
1999
19
Neuroimaging of the AIDS dementia complex. (9517985)
1998
20
Functional imaging of the AIDS dementia complex and the metabolic pathology of the HIV-1-infected brain. (9376962)
1997
21
HIV encephalitis and HIV leukoencephalopathy are associated with distinct clinical and radiological subtypes of the AIDS dementia complex. (9108957)
1997
22
Transient infection of astrocytes with HIV-1 primary isolates derived from patients with and without AIDS dementia complex. (9475117)
1997
23
The cellular basis of central nervous system HIV-1 infection and the AIDS dementia complex: introduction. (16873153)
1996
24
Genetic and biological analysis of variants derived from the cerebrospinal fluid of HIV type 1 subtype B- and D- infected patients with and without AIDS dementia complex. (8947301)
1996
25
Transgenic models in the study of AIDS dementia complex. (8608719)
1996
26
AIDS dementia complex: a complex, slow virus "model" of acquired genetic neurodegenerative disease. (9246501)
1996
27
The role of the consultation-liaison nurse. Caring for patients with AIDS dementia complex. (8667308)
1995
28
Differences in human immunodeficiency virus type 1 V3 sequences from patients with and without AIDS dementia complex. (7844529)
1995
29
AIDS dementia complex. (7732098)
1994
30
AIDS dementia complex. (8035256)
1994
31
Persistent neuroleptic-induced rigidity and dystonia in AIDS dementia complex: a clinico-pathological case report. (7699386)
1994
32
Zidovudine treatment of the AIDS dementia complex: results of a placebo-controlled trial. AIDS Clinical Trials Group. (8489204)
1993
33
White matter lesions and cerebral atrophy on MR images in patients with and without AIDS dementia complex. (8517298)
1993
34
AIDS dementia complex complicated by cytomegalovirus encephalopathy. (8388434)
1993
35
Computer-based neuropsychological screening for AIDS dementia complex. (8318175)
1993
36
Cerebrospinal fluid T cell receptor gamma/delta+ lymphocyte subsets in patient with AIDS-dementia complex. (1414465)
1992
37
Detection of a vigorous HIV-1-specific cytotoxic T lymphocyte response in cerebrospinal fluid from infected persons with AIDS dementia complex. (1383338)
1992
38
Cerebrospinal fluid myelin basic protein as predictive marker of demyelination in AIDS dementia complex. (1370671)
1992
39
Methods for detecting early signs of AIDS dementia complex in asymptomatic HIV-1-infected subjects. (1361744)
1992
40
Cerebrospinal fluid beta-2-microglobulin in multiple sclerosis and AIDS dementia complex. (1355285)
1992
41
Aids dementia complex. On the relationship between HIV-1 infection, immune-mediated response and myelin damage in the brain. (1891984)
1991
42
AIDS dementia complex in health care providers: do treating physicians have an ethical and legal duty to protect endangered patients? (11651196)
1991
43
Early HIV-1 infection and the AIDS dementia complex. (2300258)
1990
44
Evaluation of the AIDS dementia complex in clinical trials. (2231303)
1990
45
The AIDS dementia complex and HIV-1 brain infection: a pathogenetic model of virus-immune interaction. (2183316)
1990
46
Tumor necrosis factor alpha (TNF alpha) and neurological diseases. Failure in detecting TNF alpha in the cerebrospinal fluid from patients with multiple sclerosis, AIDS dementia complex, and brain tumours. (2723041)
1989
47
Zidovudine in AIDS dementia complex. (2513062)
1989
48
AIDS dementia complex. (3411540)
1988
49
HIV antigen in the brains of patients with the AIDS dementia complex. (3296948)
1987
50
The metabolic pathology of the AIDS dementia complex. (3501695)
1987

Genetic Variations for Aids Dementia Complex

Expression for genes affiliated with Aids Dementia Complex

Sources:
1BioGPS, 15Gene Expression Omnibus DataSets
See all sources
Expression patterns in normal tissues for genes affiliated with Aids Dementia Complex

Search GEO for disease gene expression data for Aids Dementia Complex.

Pathways for genes affiliated with Aids Dementia Complex

Sources:
30KEGG, 38NCBI BioSystems Database, 54Reactome, 12EMD Millipore, 52QIAGEN, 56SinoBiological, 53R&D Systems
See all sources

Pathways related to Aids Dementia Complex according to GeneCards/GeneDecks:

(show all 21)
idSuper pathways (with members indented)ScoreTop Affiliating Genes
1
Hide members
10.3CCR5
210.3SLC6A3
3
Hide members
10.1CXCR4, CCR5
49.9NOS2, CXCL12, CXCR4
5
Hide members
9.9CCR5, B2M, IL1B
69.8CXCL12, TNF, IL1B
7
Immune response Bacterial infections in normal airways
Hide members
9.8TNF, IL1B, NOS2
89.8TNF, IL1B, NOS2
99.8CCR3, CCR5, CXCR4, CXCL12
10
Hide members
9.8CXCL12, CXCR4, CCR3, CCR5
119.8IL1B, F2RL1, TNF
12
Hide members
9.7CXCR4, CCR3, CCR5, F2RL1
13
Hide members
9.7CCR5, PLAUR, CXCL12, CXCR4, CCR3
14
Hide members
9.6CXCL12, IL1B, BDNF, TNF
15
Hide members
9.6BDNF, TNF, B2M, CD27
16
Hide members
9.5TNF, IL1B, CXCL12, CXCR4, B2M
17
Hide members
9.4CXCL12, BDNF, CCR5, CCR3, CXCR4, CD27
189.3NOS2, BDNF, TNF, MBP, IL1B
19
Hide members
9.2CXCL12, CXCR4, TNF, CCR3, IL1B, CCR5
20
Hide members
9.2BDNF, CCR5, TNF, CXCR4, IL1B, CCR3
21
Hide members
9.2BDNF, IL1B, CXCL12, CXCR4, TNF, CCR3

Compounds for genes affiliated with Aids Dementia Complex

Sources:
45Novoseek, 50PharmGKB, 29IUPHAR, 11DrugBank, 60Tocris Bioscience, 2BitterDB, 24HMDB
See all sources

Compounds related to Aids Dementia Complex according to GeneCards/GeneDecks:

(show top 50)    (show all 158)
idCompoundScoreTop Affiliating Genes
1pge24510.8ITIH4
2cycloheximide4510.6TAT, CXCL12
3estrogen4510.5TAT
4butyrate4510.3CCR5, CCR3, B2M
5dexamethasone45 50 29 1113.2PLAUR, TAT, CXCL12, CCR3
6bicyclam4510.2CCR5, CXCR4, CXCL12, ITIH4
7c-d4i4510.2CXCR4, ITIH4, CCR5
8mdms4510.1TAT, CCR5, CXCL12, CXCR4
9indomethacin45 60 29 1113.0BDNF, PLAUR, TAT, ITIH4, MBP
10galactosylceramide4510.0CXCR4, CXCL12, ITIH4, CCR5, MBP
11glutamate459.9TAT, SLC6A3, SLC1A2, ITIH4, MBP
12quinine45 29 2 1112.9CCR3, BDNF, CCR5, CXCR4, CXCL12
13tarc459.9TNF, CCR3, CCR5, CXCR4, CXCL12
14zidovudine45 1110.9CXCL12, CXCR4, B2M, TAT, CCR5, ITIH4
15morphine45 50 29 1112.9SLC6A3, CXCR4, ITIH4, CCR3, CCR5, TAT
16opiate459.8ITIH4, SLC6A3, F2RL1, TAT, CCR3, CCR5
17oxygen45 2410.8CCR3, TNF, F2RL1, SLC1A2, NOS2
18h2o2459.8MBP, SLC6A3, SLC1A2, ITIH4, PLAUR
19rantes459.7CXCL12, IL1B, F2RL1, CXCR4, ITIH4, TNF
20cyclosporin a45 29 6011.7B2M, F2RL1, TAT, CXCR4, MBP, ITIH4
21nmda45 2910.7SLC6A3, BDNF, ITIH4, CXCR4, CXCL12, SLC1A2
22groalpha459.7TNF, IL1B, CCR5, CXCL12
23heparin45 29 11 2412.7CCR3, ITIH4, CCR5, CXCL12, TAT, F2RL1
24ccl345 2910.7TAT, IL1B, CXCR4, TNF, CCR3, CCR5
25cocaine45 1110.7BDNF, CCR5, ITIH4, TAT, MBP, SLC6A3
26herbimycin a45 6010.6IL1B, TNF, PLAUR, CXCR4, NOS2, CXCL12
27corticosterone45 60 2411.6MBP, BDNF, ITIH4, IL1B, TAT
28serine459.6SLC1A2, CCR5, B2M, F2RL1, SLC6A3, TNF
29ly294002459.5CXCR4, CXCL12, TNF, IL1B, F2RL1, NOS2
30aspartate459.5CXCR4, BDNF, CCR5, ITIH4, B2M, TAT
31superoxide45 2410.5SLC1A2, F2RL1, IL1B, TNF
32glutamine459.4TAT, SLC1A2, PLAUR, CCR5, MBP, ITIH4
33sb 20358045 6010.4TNF, CXCL12, IL1B, F2RL1, PLAUR, NOS2
34sodium45 2410.4SLC1A2, SLC6A3, TAT, F2RL1
35pd 98,059459.3PLAUR, BDNF, TNF, CXCL12, IL1B, F2RL1
36gaba459.3BDNF, SLC6A3, F2RL1, CXCL12, SLC1A2, MBP
37histamine45 29 2411.3TAT, IL1B, BDNF, F2RL1, CXCR4, TNF
38lactate459.3TNF, BDNF, MBP, TAT, ITIH4, B2M
39adenylate459.2NOS2, SLC1A2, TAT, CXCL12, CXCR4, ITIH4
40n acetylcysteine459.2NOS2, IL1B, TNF, MBP, BDNF, PLAUR
41dopamine45 29 11 2412.1ITIH4, TAT, F2RL1, SLC1A2, SLC6A3, TPPP3
42thymidine45 2410.0IL1B, BDNF, CCR3, MBP, TNF, B2M
43genistein45 29 60 2 11 2414.0CCR3, B2M, CXCL12, IL1B, F2RL1, PLAUR
44vegf458.9PLAUR, IL1B, CXCR4, TNF, NOS2, BDNF
45retinoic acid45 249.9PLAUR, TAT, IL1B, CXCR4, B2M, CCR5
46alanine458.9CCR5, CCR3, MBP, SLC6A3, ITIH4, B2M
47arginine458.8CCR5, NOS2, SLC6A3, SLC1A2, PLAUR, F2RL1
48cysteine458.8TAT, CD27, B2M, ITIH4, MBP, CCR3
49actinomycin d458.7NOS2, F2RL1, BDNF, IL1B, CXCL12, TAT
50tyrosine458.6TAT, CXCL12, CXCR4, BDNF, CCR5, MBP

GO Terms for genes affiliated with Aids Dementia Complex

Sources:
16Gene Ontology
See all sources

Cellular components related to Aids Dementia Complex according to GeneCards/GeneDecks:

idNameGO IDScoreTop Affiliating Genes
1external side of plasma membraneGO:0098979.3CXCL12, CXCR4, CD27, B2M, TNF, CCR5
2integral to plasma membraneGO:0058879.1CCR3, TNF, CD27, F2RL1, PLAUR, SLC6A3
3extracellular regionGO:0055768.6BDNF, TNF, ITIH4, B2M, CD27, CXCL12
4plasma membraneGO:0058868.0ITIH4, TNF, MBP, CCR3, CCR5, B2M

Biological processes related to Aids Dementia Complex according to GeneCards/GeneDecks:

(show all 23)
idNameGO IDScoreTop Affiliating Genes
1entry into host cellGO:03026010.4CXCR4, CCR5
2positive regulation of calcidiol 1-monooxygenase activityGO:06055910.3TNF, IL1B
3ameboidal cell migrationGO:00166710.3CXCL12, CXCR4
4sequestering of triglycerideGO:03073010.3TNF, IL1B
5chemokine-mediated signaling pathwayGO:07009810.3CCR5, CCR3, CXCL12
6positive regulation of heterotypic cell-cell adhesionGO:03411610.3IL1B, TNF
7positive regulation of fever generationGO:03162210.3IL1B, TNF
8germ cell migrationGO:00835410.2CXCL12, CXCR4
9positive regulation of chemokine biosynthetic processGO:04508010.2IL1B, TNF
10calcium-mediated signalingGO:01972210.2CCR5, TNF, CXCR4
11chemotaxisGO:00693510.1PLAUR, CXCL12, CCR3, CCR5
12neutrophil activationGO:04211910.1F2RL1, CXCR4
13regulation of I-kappaB kinase/NF-kappaB cascadeGO:04312210.1F2RL1, IL1B, TNF
14MAPK cascadeGO:00016510.1CCR5, TNF, IL1B
15elevation of cytosolic calcium ion concentrationGO:00720410.1CCR5, CCR3, CXCR4, F2RL1
16positive regulation of membrane protein ectodomain proteolysisGO:05104410.0IL1B, TNF
17regulation of insulin secretionGO:05079610.0TNF, IL1B, NOS2
18response to hypoxiaGO:00166610.0NOS2, CXCR4, TNF, BDNF
19leukocyte tethering or rollingGO:0509019.9GOLPH3, TNF
20positive regulation of JNK cascadeGO:0463309.9TNF, CD27, IL1B, F2RL1
21response to drugGO:0424939.6TNF, B2M, SLC1A2, SLC6A3
22activation of MAPK activityGO:0001879.6IL1B, CXCR4, TNF
23inflammatory responseGO:0069549.4NOS2, F2RL1, IL1B, CXCR4, TNF, CCR3

Molecular functions related to Aids Dementia Complex according to GeneCards/GeneDecks:

idNameGO IDScoreTop Affiliating Genes
1C-C chemokine receptor activityGO:01649310.2CCR3, CCR5
2protease bindingGO:0020209.7MBP, TNF, SLC6A3
3receptor bindingGO:0051029.3NOS2, SLC6A3, F2RL1, CXCL12
4protein bindingGO:0055157.6GOLPH3, CCR5, CCR3, MBP, TNF, ITIH4

Products for genes affiliated with Aids Dementia Complex

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  • Proteins
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  • Antibodies

Sources for Aids Dementia Complex

3CDC
13ExPASy
14FMA
22GTR
23HGMD
24HMDB
25ICD10
26ICD10 via Orphanet
27ICD9CM
29IUPHAR
30KEGG
35MeSH
36MESH via Orphanet
37MGI
40NCIt
41NDF-RT
44NINDS
45Novoseek
47OMIM
48OMIM via Orphanet
51PubMed
52QIAGEN
58SNOMED-CT via Orphanet
61UMLS
62UMLS via Orphanet