ADC
MCID: ADS004
MIFTS: 38

Aids Dementia Complex (ADC) malady

Summaries for Aids Dementia Complex

About this section
Sources:
63Wikipedia, 32MalaCards
See all sources

Fully expand this MalaCard

Export this MalaCard
Wikipedia:63 HIV-associated neurocognitive disorder (HAND) is a common umbrella term for neurological disorders... more...

MalaCards: Aids Dementia Complex, also known as aids related cognitive impairment, is related to dementia and kaposi's sarcoma. An important gene associated with Aids Dementia Complex is ITIH4 (inter-alpha-trypsin inhibitor heavy chain family, member 4), and among its related pathways are Leishmaniasis and Monoamine Transport. The compounds pge2 and cycloheximide have been mentioned in the context of this disorder. Affiliated tissues include monocytes, and related mouse phenotypes are reproductive system and tumorigenesis.

Aliases & Classifications for Aids Dementia Complex

About this section
Sources:
42NIH Rare Diseases, 44Novoseek, 60UMLS
See all sources

Aliases & Descriptions:

aids dementia complex 42 44 60
aids related cognitive impairment 42
adc 42


Related Diseases for Aids Dementia Complex

About this section
Sources:
17GeneCards, 18GeneDecks
See all sources

Diseases related to Aids Dementia Complex via text searches within MalaCards or GeneCards/GeneDecks gene sharing:

(show top 50)    (show all 206)
idRelated DiseaseScoreTop Affiliating Genes
1dementia31.8TPPP3, SLC6A3, SLC1A2, TAT, CXCL12, CXCR4
2kaposi's sarcoma30.5TAT
3sarcoma30.5TAT
4multiple sclerosis30.5TPPP3, NOS2, IL1B, CXCL12, CD27, TNF
5brain disease30.4TAT, ITIH4, MBP
6acquired immunodeficiency syndrome30.4TAT, IL1B, CXCL12, B2M, CCR3, CCR5
7hepatitis30.3CXCL12, TAT
8cocaine abuse30.2SLC6A3
9schizophrenia30.1BDNF, MBP, F2RL1, SLC1A2, SLC6A3, TPPP3
10encephalitis30.1MBP, CCR5, ITIH4, CXCR4, TPPP3, NOS2
11alzheimer's disease30.1BDNF, CCR3, ITIH4, CXCL12, IL1B, PLAUR
12breast cancer30.0CXCR4, CXCL12, F2RL1, PLAUR, NOS2
13hypoglycemia29.8BDNF
14pneumonia29.8IL1B, TNF
15pancreatitis29.8IL1B, F2RL1
16encephalomyelitis29.8CCR5, MBP, TNF, NOS2
17pancreatic cancer29.8BDNF, CXCR4, CXCL12, F2RL1, PLAUR
18inflammatory bowel disease29.8CCR5, TNF, IL1B, F2RL1, NOS2
19prostate cancer29.8BDNF, CCR5, CXCR4, CXCL12, F2RL1, PLAUR
20neuronitis10.4
21cerebritis10.4
22image syndrome10.3
23chronic fatigue syndrome10.1
24hydrocephalus10.1
25toxoplasmosis10.1
26neurologic diseases10.1
27normal pressure hydrocephalus10.0
28hyperargininemia10.0
29hypertension10.0
30lung cancer10.0
31prostatitis10.0
32viral hepatitis10.0
33spinal cord injury10.0
34macroglobulinemia10.0B2M
35liver cirrhosis10.0TAT
36atopy10.0CCR3
37sjogren's syndrome10.0B2M
38esophagitis10.0CCR3
39chagas disease10.0CCR5
40allergic rhinitis10.0CCR3
41thrombocytopenia10.0CXCR4
42neuroblastoma10.0BDNF
43wilson disease10.0SLC6A3
44disseminated intravascular coagulation10.0TAT
45neuropathy10.0MBP
46essential hypertension10.0CCR5
47neuritis10.0MBP
48optic neuritis10.0MBP
49pemphigus10.0PLAUR
50gingivitis10.0IL1B

Graphical network of the top 20 diseases related to Aids Dementia Complex:



Diseases related to aids dementia complex

Clinical Features for Aids Dementia Complex

About this section

Drugs & Therapeutics for Aids Dementia Complex

About this section
Sources:
5CenterWatch, 41NIH Clinical Center, 6ClinicalTrials, 60UMLS, 40NDF-RT
See all sources

Approved drugs:

Search CenterWatch for Aids Dementia Complex

Drug clinical trials:

Search ClinicalTrials for Aids Dementia Complex

Search NIH Clinical Center for Aids Dementia Complex

Search CenterWatch for Aids Dementia Complex

Genetic Tests for Aids Dementia Complex

About this section

Anatomical Context for Aids Dementia Complex

About this section
Sources:
32MalaCards
See all sources

MalaCards organs/tissues related to Aids Dementia Complex:

32
Monocytes

Animal Models for Aids Dementia Complex or affiliated genes

About this section
Sources:
36MGI
See all sources

MGI Mouse Phenotypes related to Aids Dementia Complex:

36 (show all 12)
idDescriptionMGI Source AccessionScoreTop Affiliating Genes
1MP:000538910.0BDNF, CCR5, SLC6A3
2MP:00020069.6NOS2, IL1B, ITIH4, TNF, CCR5
3MP:00036319.5BDNF, CCR5, F2RL1, SLC1A2, SLC6A3, NOS2
4MP:00053699.3CCR5, CXCR4, CXCL12, PLAUR, SLC6A3
5MP:00053709.1CCR5, TNF, ITIH4, B2M, CXCL12, F2RL1
6MP:00053768.9BDNF, CCR5, CCR3, MBP, B2M, CXCR4
7MP:00053858.6CCR5, TNF, B2M, CXCR4, CXCL12, IL1B
8MP:00053868.6CCR5, MBP, TNF, F2RL1, PLAUR, SLC1A2
9MP:00053978.5CCR5, CCR3, MBP, TNF, B2M, CD27
10MP:00053878.3CCR5, CCR3, MBP, TNF, B2M, CD27
11MP:00053848.0NOS2, BDNF, CCR5, CCR3, MBP, TNF
12MP:00107688.0B2M, TNF, MBP, CCR5, BDNF, CXCR4

Publications for Aids Dementia Complex

About this section

Genetic Variations for Aids Dementia Complex

About this section

Expression for genes affiliated with Aids Dementia Complex

About this section
Sources:
1BioGPS, 15Gene Expression Omnibus DataSets
See all sources
Expression patterns in normal tissues for genes affiliated with Aids Dementia Complex

Search GEO for disease gene expression data for Aids Dementia Complex.

Pathways for genes affiliated with Aids Dementia Complex

About this section
Sources:
29KEGG, 37NCBI BioSystems Database, 53Reactome, 12EMD Millipore, 51QIAGEN, 55SinoBiological, 52R&D Systems
See all sources

Pathways related to Aids Dementia Complex according to GeneCards/GeneDecks:

(show all 21)
idSuper pathways (with members indented)ScoreTop Affiliating Genes
1
Hide members
10.3CCR5
210.3SLC6A3
3
Hide members
10.1CXCR4, CCR5
49.9NOS2, CXCL12, CXCR4
5
Hide members
9.9IL1B, B2M, CCR5
69.8IL1B, CXCL12, TNF
7
Immune response Bacterial infections in normal airways
Hide members
9.8TNF, IL1B, NOS2
89.8TNF, IL1B, NOS2
99.8CCR5, CCR3, CXCR4, CXCL12
10
Hide members
9.8CCR5, CCR3, CXCR4, CXCL12
119.8F2RL1, IL1B, TNF
12
Hide members
9.7F2RL1, CXCR4, CCR3, CCR5
13
Hide members
9.7CCR5, CCR3, CXCR4, CXCL12, PLAUR
14
Hide members
9.6IL1B, CXCL12, TNF, BDNF
15
Hide members
9.6BDNF, TNF, B2M, CD27
16
Hide members
9.5TNF, B2M, CXCR4, CXCL12, IL1B
17
Hide members
9.4CXCL12, CXCR4, CD27, CCR3, CCR5, BDNF
189.3BDNF, MBP, TNF, IL1B, NOS2
19
Hide members
9.2BDNF, CCR5, CCR3, TNF, CXCR4, CXCL12
20
Hide members
9.2BDNF, CCR5, CCR3, TNF, CXCR4, CXCL12
21
Hide members
9.2BDNF, CCR5, CCR3, TNF, CXCR4, CXCL12

Compounds for genes affiliated with Aids Dementia Complex

About this section
Sources:
44Novoseek, 49PharmGKB, 28IUPHAR, 11DrugBank, 59Tocris Bioscience, 2BitterDB, 24HMDB
See all sources

Compounds related to Aids Dementia Complex according to GeneCards/GeneDecks:

(show top 50)    (show all 158)
idCompoundScoreTop Affiliating Genes
1pge24410.8ITIH4
2cycloheximide4410.6CXCL12, TAT
3estrogen4410.5TAT
4butyrate4410.3B2M, CCR3, CCR5
5dexamethasone44 49 28 1113.2CCR3, CXCL12, TAT, PLAUR
6bicyclam4410.2CCR5, ITIH4, CXCR4, CXCL12
7c-d4i4410.2CCR5, ITIH4, CXCR4
8mdms4410.1CCR5, CXCR4, CXCL12, TAT
9indomethacin44 59 28 1113.0BDNF, MBP, ITIH4, TAT, PLAUR
10galactosylceramide4410.0CCR5, MBP, ITIH4, CXCR4, CXCL12
11glutamate449.9MBP, ITIH4, TAT, SLC1A2, SLC6A3
12quinine44 28 2 1112.9CXCL12, CXCR4, CCR3, CCR5, BDNF
13tarc449.9CCR5, CCR3, TNF, CXCR4, CXCL12
14zidovudine44 1110.9CCR5, ITIH4, B2M, CXCR4, CXCL12, TAT
15morphine44 49 28 1112.9CCR5, CCR3, ITIH4, CXCR4, TAT, SLC6A3
16opiate449.8CCR5, CCR3, ITIH4, TAT, F2RL1, SLC6A3
17oxygen44 2410.8CCR3, TNF, F2RL1, SLC1A2, NOS2
18h2o2449.8MBP, ITIH4, PLAUR, SLC1A2, SLC6A3
19rantes449.7TNF, ITIH4, CXCR4, CXCL12, IL1B, F2RL1
20cyclosporin a44 28 5911.7MBP, ITIH4, B2M, CXCR4, TAT, F2RL1
21nmda44 2810.7BDNF, ITIH4, CXCR4, CXCL12, TAT, SLC1A2
22groalpha449.7CCR5, TNF, CXCL12, IL1B
23heparin44 28 11 2412.7CCR5, CCR3, ITIH4, CXCR4, CXCL12, TAT
24ccl344 2810.7CCR5, CCR3, TNF, CXCR4, CXCL12, IL1B
25cocaine44 1110.7BDNF, CCR5, MBP, ITIH4, TAT, SLC6A3
26herbimycin a44 5910.6CCR3, TNF, CXCR4, CXCL12, IL1B, PLAUR
27corticosterone44 59 2411.6BDNF, MBP, ITIH4, IL1B, TAT
28serine449.6CCR5, TNF, B2M, TAT, F2RL1, SLC1A2
29ly294002449.5TNF, CXCR4, CXCL12, IL1B, F2RL1, NOS2
30aspartate449.5BDNF, CCR5, ITIH4, B2M, CXCR4, TAT
31superoxide44 2410.5TNF, IL1B, F2RL1, SLC1A2
32glutamine449.4CCR5, MBP, ITIH4, B2M, TAT, PLAUR
33sb 20358044 5910.4TNF, CXCR4, CXCL12, IL1B, F2RL1, PLAUR
34sodium44 2410.4TAT, F2RL1, SLC1A2, SLC6A3
35pd 98,059449.3BDNF, TNF, CXCR4, CXCL12, IL1B, F2RL1
36gaba449.3BDNF, MBP, CXCL12, F2RL1, SLC1A2, SLC6A3
37histamine44 28 2411.3BDNF, CCR5, CCR3, TNF, CXCR4, IL1B
38lactate449.3BDNF, MBP, TNF, ITIH4, B2M, CXCR4
39adenylate449.2BDNF, CCR3, MBP, ITIH4, CXCR4, CXCL12
40n acetylcysteine449.2NOS2, PLAUR, IL1B, TNF, MBP, BDNF
41dopamine44 28 11 2412.1BDNF, ITIH4, TAT, F2RL1, SLC1A2, SLC6A3
42thymidine44 2410.0BDNF, CCR3, MBP, TNF, B2M, CXCL12
43genistein44 28 59 2 11 2414.0CCR3, TNF, B2M, CXCL12, IL1B, TAT
44vegf448.9BDNF, TNF, B2M, CXCR4, CXCL12, IL1B
45retinoic acid44 249.9BDNF, CCR5, CCR3, MBP, TNF, B2M
46alanine448.9CCR5, CCR3, MBP, ITIH4, B2M, CXCR4
47arginine448.8CCR5, MBP, ITIH4, CXCR4, CXCL12, TAT
48cysteine448.8CCR5, CCR3, MBP, ITIH4, B2M, CD27
49actinomycin d448.7NOS2, BDNF, CCR5, CCR3, TNF, ITIH4
50tyrosine448.6BDNF, CCR5, CCR3, MBP, ITIH4, CXCR4

GO Terms for genes affiliated with Aids Dementia Complex

About this section
Sources:
16Gene Ontology
See all sources

Cellular components related to Aids Dementia Complex according to GeneCards/GeneDecks:

idNameGO IDScoreTop Affiliating Genes
1external side of plasma membraneGO:0098979.3CXCL12, CXCR4, CD27, B2M, TNF, CCR5
2integral to plasma membraneGO:0058879.1CCR3, TNF, CD27, F2RL1, PLAUR, SLC6A3
3extracellular regionGO:0055768.6BDNF, TNF, ITIH4, B2M, CD27, CXCL12
4plasma membraneGO:0058868.0ITIH4, TNF, MBP, CCR3, CCR5, B2M

Biological processes related to Aids Dementia Complex according to GeneCards/GeneDecks:

(show all 23)
idNameGO IDScoreTop Affiliating Genes
1entry into host cellGO:03026010.4CXCR4, CCR5
2positive regulation of calcidiol 1-monooxygenase activityGO:06055910.3TNF, IL1B
3ameboidal cell migrationGO:00166710.3CXCL12, CXCR4
4sequestering of triglycerideGO:03073010.3TNF, IL1B
5chemokine-mediated signaling pathwayGO:07009810.3CCR5, CCR3, CXCL12
6positive regulation of heterotypic cell-cell adhesionGO:03411610.3IL1B, TNF
7positive regulation of fever generationGO:03162210.3IL1B, TNF
8germ cell migrationGO:00835410.2CXCL12, CXCR4
9positive regulation of chemokine biosynthetic processGO:04508010.2IL1B, TNF
10calcium-mediated signalingGO:01972210.2CCR5, TNF, CXCR4
11chemotaxisGO:00693510.1PLAUR, CXCL12, CCR3, CCR5
12neutrophil activationGO:04211910.1F2RL1, CXCR4
13regulation of I-kappaB kinase/NF-kappaB cascadeGO:04312210.1F2RL1, IL1B, TNF
14MAPK cascadeGO:00016510.1CCR5, TNF, IL1B
15elevation of cytosolic calcium ion concentrationGO:00720410.1CCR5, CCR3, CXCR4, F2RL1
16positive regulation of membrane protein ectodomain proteolysisGO:05104410.0IL1B, TNF
17regulation of insulin secretionGO:05079610.0TNF, IL1B, NOS2
18response to hypoxiaGO:00166610.0NOS2, CXCR4, TNF, BDNF
19leukocyte tethering or rollingGO:0509019.9GOLPH3, TNF
20positive regulation of JNK cascadeGO:0463309.9TNF, CD27, IL1B, F2RL1
21response to drugGO:0424939.6TNF, B2M, SLC1A2, SLC6A3
22activation of MAPK activityGO:0001879.6IL1B, CXCR4, TNF
23inflammatory responseGO:0069549.4NOS2, F2RL1, IL1B, CXCR4, TNF, CCR3

Molecular functions related to Aids Dementia Complex according to GeneCards/GeneDecks:

idNameGO IDScoreTop Affiliating Genes
1C-C chemokine receptor activityGO:01649310.2CCR3, CCR5
2protease bindingGO:0020209.7MBP, TNF, SLC6A3
3receptor bindingGO:0051029.3NOS2, SLC6A3, F2RL1, CXCL12
4protein bindingGO:0055157.6GOLPH3, CCR5, CCR3, MBP, TNF, ITIH4

Products for genes affiliated with Aids Dementia Complex

About this section
  • Antibodies
  • Proteins
  • Lysates
  • Antibodies

Sources for Aids Dementia Complex

About this section
3CDC
13ExPASy
14FMA
22GTR
23HGMD
24HMDB
25ICD10
26ICD10 via Orphanet
27ICD9CM
28IUPHAR
29KEGG
34MeSH
35MESH via Orphanet
36MGI
39NCIt
40NDF-RT
43NINDS
44Novoseek
46OMIM
47OMIM via Orphanet
50PubMed
51QIAGEN
57SNOMED-CT via Orphanet
60UMLS
61UMLS via Orphanet