ADC
MCID: ADS004
MIFTS: 40

Aids Dementia Complex (ADC) malady

Rare diseases, Mental diseases categories
Download this MalaCard

Summaries for Aids Dementia Complex

About this section
Sources:
65Wikipedia, 33MalaCards
See all sources

Fully expand this MalaCard
Wikipedia:65 HIV-associated neurocognitive disorder (HAND) is a common umbrella term for neurological disorders... more...

MalaCards: Aids Dementia Complex, also known as aids related cognitive impairment, is related to dementia and kaposi's sarcoma. An important gene associated with Aids Dementia Complex is ITIH4 (inter-alpha-trypsin inhibitor heavy chain family, member 4). The compounds dizocilpine and memantine have been mentioned in the context of this disorder. Affiliated tissues include monocytes, brain and testes, and related mouse phenotypes are liver/biliary system and cellular.

Aliases & Classifications for Aids Dementia Complex

About this section
Sources:
43NIH Rare Diseases, 45Novoseek, 62UMLS
See all sources

Classifications:

Malacards categories (disease lists): (See all malacards categories)
Global: Rare diseases
Anatomical: Mental diseases


Aliases & Descriptions:

aids dementia complex 43 45 62
aids related cognitive impairment 43
adc 43


Related Diseases for Aids Dementia Complex

About this section
Sources:
17GeneCards, 18GeneDecks
See all sources

Graphical network of the top 20 diseases related to Aids Dementia Complex:



Diseases related to aids dementia complex

Symptoms for Aids Dementia Complex

About this section

Drugs & Therapeutics for Aids Dementia Complex

About this section
Sources:
42NIH Clinical Center, 6ClinicalTrials, 62UMLS, 41NDF-RT
See all sources

Drug clinical trials:

Search ClinicalTrials for Aids Dementia Complex

Search NIH Clinical Center for Aids Dementia Complex

Genetic Tests for Aids Dementia Complex

About this section

Anatomical Context for Aids Dementia Complex

About this section
Sources:
33MalaCards
See all sources

MalaCards organs/tissues related to Aids Dementia Complex:

33
Monocytes, Brain, Testes, T cells, Cortex

Animal Models for Aids Dementia Complex or affiliated genes

About this section
Sources:
37MGI
See all sources

MGI Mouse Phenotypes related to Aids Dementia Complex:

37
idDescriptionMGI Source AccessionScoreTop Affiliating Genes
1MP:00053708.7PLAUR, ITIH4, B2M
2MP:00053847.9PLAUR, ITIH4, CCR3, B2M

Publications for Aids Dementia Complex

About this section
Sources:
52PubMed
See all sources

Articles related to Aids Dementia Complex:

(show top 50)    (show all 184)
idTitleAuthorsYear
1
Memantine for AIDS dementia complex: open-label report of ACTG 301. (20400412)
2010
2
Validity of the CogState brief battery: relationship to standardized tests and sensitivity to cognitive impairment in mild traumatic brain injury, schizophrenia, and AIDS dementia complex. (19395350)
2009
3
High level HIV-1 DNA concentrations in brain tissues differentiate patients with post-HAART AIDS dementia complex or cardiovascular disease from those with AIDS. (19641870)
2009
4
Communication impairment in the AIDS dementia complex (ADC): a case report. (18242630)
2008
5
Prevalence of AIDS dementia complex: results from a statewide population-based registry of Alzheimer's disease and related disorders. (19058735)
2008
6
AIDS dementia complex in China. (17070055)
2007
7
Cerebrospinal fluid markers in central nervous system HIV infection and AIDS dementia complex. (18808988)
2007
8
AIDS dementia complex and Hashimoto encephalopathy in a senescent woman. (18033678)
2007
9
AIDS dementia complex. (16909695)
2006
10
Inflammation and neuroaxonal injury in multiple sclerosis and AIDS dementia complex: implications for neuroprotective treatment. (16138246)
2005
11
The AIDS dementia complex: clinical and basic neuroscience with implications for novel molecular therapies. (16260383)
2005
12
Involvement of quinolinic acid in AIDS dementia complex. (15639803)
2005
13
A multi-center 1H MRS study of the AIDS dementia complex: validation and preliminary analysis. (12766890)
2003
14
Elevated levels of soluble Fas and Fas ligand in cerebrospinal fluid of patients with AIDS dementia complex. (11240032)
2001
15
Human Herpesvirus 8 and Protection from AIDS Dementia Complex. (11867000)
2000
16
AIDS dementia complex. (10517932)
1999
17
Anomalies in Nef expression within the central nervous system of HIV-1 positive individuals/AIDS patients with or without AIDS dementia complex. (9639072)
1998
18
Pathogenic mechanisms of neuronal damage in the AIDS dementia complex. (9231153)
1997
19
The neuropathogenesis of the AIDS dementia complex. (9451964)
1997
20
The relationship between AIDS dementia complex and the presence of macrophage tropic and non-syncytium inducing isolates of human immunodeficiency virus type 1 in the cerebrospinal fluid. (8799207)
1996
21
The cellular basis of central nervous system HIV-1 infection and the AIDS dementia complex: introduction. (16873153)
1996
22
Genetic and biological analysis of variants derived from the cerebrospinal fluid of HIV type 1 subtype B- and D- infected patients with and without AIDS dementia complex. (8947301)
1996
23
Epidemiology of AIDS dementia complex in Europe. AIDS in Europe Study Group. (8528731)
1996
24
Cellular basis of HIV infection of the CNS and the AIDS dementia complex: oligodendrocyte. (16873159)
1996
25
AIDS dementia complex: incidence, clinical profile and impact of zidovudine treatment*. (21284769)
1996
26
Astrocytes and the AIDS dementia complex. (16873158)
1996
27
Review of antiretroviral therapy in the prevention of HIV-related AIDS dementia complex (ADC). (7614899)
1995
28
Trypsin inhibition: a potential cause of cobalamin deficiency common to the pathogenesis of Alzheimer-type dementia and AIDS dementia complex? (8531843)
1995
29
More acquired immunodeficiency syndrome (AIDS) dementia complex in Japan? (8563090)
1995
30
Management of AIDS dementia complex and HIV-1 infection of the nervous system. (8819589)
1995
31
The role of the consultation-liaison nurse. Caring for patients with AIDS dementia complex. (8667308)
1995
32
Neuropsychological characterization of the AIDS dementia complex and rationalization of a test battery. (8018042)
1994
33
Cerebrospinal fluid HIV-1 p24 antigen and culture: sensitivity and specificity for AIDS-dementia complex. (8021661)
1994
34
SPECT imaging of the brain: comparison of findings in patients with chronic fatigue syndrome, AIDS dementia complex, and major unipolar depression. (8141022)
1994
35
Zidovudine treatment of the AIDS dementia complex: results of a placebo-controlled trial. AIDS Clinical Trials Group. (8489204)
1993
36
Cerebrospinal fluid beta 2-microglobulin in patients with AIDS dementia complex: an expanded series including response to zidovudine treatment. (1616651)
1992
37
Cerebrospinal fluid myelin basic protein in AIDS dementia complex: relationship to disease progression and zidovudine treatment. (1281644)
1992
38
Proton MR spectroscopy of the brain in AIDS dementia complex. (1629410)
1992
39
Single photon emission computed tomography with 99mTc-HMPAO in HIV-1 infection: a help in early diagnosis of AIDS dementia complex. (1927637)
1991
40
Detection of cerebrospinal fluid antibodies against myelin basic protein in patients with AIDS dementia complex. (1720316)
1991
41
Aids dementia complex. On the relationship between HIV-1 infection, immune-mediated response and myelin damage in the brain. (1891984)
1991
42
Early HIV-1 infection and the AIDS dementia complex. (2300258)
1990
43
AIDS dementia complex: brain high-energy phosphate metabolite deficits. (2367655)
1990
44
The significant other's role in improving quality of life in persons with AIDS dementia complex. (2527929)
1989
45
Declining incidence of AIDS dementia complex after introduction of zidovudine treatment. (2510843)
1989
46
Tumor necrosis factor alpha (TNF alpha) and neurological diseases. Failure in detecting TNF alpha in the cerebrospinal fluid from patients with multiple sclerosis, AIDS dementia complex, and brain tumours. (2723041)
1989
47
AIDS-dementia-complex: pathology, pathogenesis and future directions. (2670816)
1989
48
Neuropsychiatric aspects of AIDS dementia complex: a report on a clinical series. (3200506)
1988
49
The brain in AIDS: central nervous system HIV-1 infection and AIDS dementia complex. (3277272)
1988
50
HIV antigen in the brains of patients with the AIDS dementia complex. (3296948)
1987

Variations for Aids Dementia Complex

About this section

Expression for genes affiliated with Aids Dementia Complex

About this section
Sources:
2BioGPS, 15Gene Expression Omnibus DataSets
See all sources
Expression patterns in normal tissues for genes affiliated with Aids Dementia Complex

Search GEO for disease gene expression data for Aids Dementia Complex.

Pathways for genes affiliated with Aids Dementia Complex

About this section

Compounds for genes affiliated with Aids Dementia Complex

About this section
Sources:
45Novoseek, 29IUPHAR, 51PharmGKB, 11DrugBank, 61Tocris Bioscience, 24HMDB, 3BitterDB
See all sources

Compounds related to Aids Dementia Complex according to GeneCards/GeneDecks:

(show top 50)    (show all 59)
idCompoundScoreTop Affiliating Genes
1dizocilpine459.8ITIH4, TAT
2memantine45 29 51 1112.8ITIH4, TAT
32,5-oligoadenylate459.7TAT, B2M
4ccl345 2910.7TAT, CCR3
5corticosterone45 61 2411.6TAT, ITIH4
6asparagine459.6TAT, ITIH4
7urea45 24 1111.6ITIH4, B2M
8nifedipine45 29 51 1112.6ITIH4, B2M
9glycolipid459.5PLAUR, ITIH4
10amiloride45 29 1111.5PLAUR, ITIH4
11lead459.5B2M, TAT
12aprotinin45 1110.5ITIH4, PLAUR
13vincristine45 51 1111.5TAT, B2M
14neopterin459.4PLAUR, B2M
15uric acid45 2410.4B2M, PLAUR
16suramin45 29 1111.4PLAUR, ITIH4
17cocaine45 1110.4ITIH4, TAT
18inositol459.4TAT, ITIH4
19opiate459.3TAT, ITIH4, CCR3
20chloroquine45 3 51 29 1113.3B2M, ITIH4, TAT
21zidovudine45 51 1111.3TAT, ITIH4, B2M
22vitamin-e459.3TAT, ITIH4, B2M
23morphine45 51 29 1112.3TAT, ITIH4, CCR3
24rantes459.3TAT, ITIH4, CCR3
25cyclosporin a45 29 6111.3TAT, ITIH4, B2M
26lactate459.2B2M, ITIH4, TAT
27aspartate459.2TAT, ITIH4, B2M
28adenylate459.2CCR3, ITIH4, TAT
29biotin45 24 1111.1PLAUR, ITIH4, B2M
30paraffin459.1PLAUR, ITIH4, B2M
31pge2459.1PLAUR, ITIH4, B2M
32thymidine45 2410.0PLAUR, CCR3, B2M
33iron45 249.9B2M, PLAUR, TAT
34arginine458.8ITIH4, PLAUR, TAT
35dexamethasone45 51 29 1111.8TAT, PLAUR, CCR3
36vegf458.8TAT, PLAUR, B2M
37indomethacin45 29 61 1111.5B2M, ITIH4, PLAUR, TAT
38actinomycin d458.5CCR3, ITIH4, PLAUR, TAT
39glutamine458.5B2M, ITIH4, PLAUR, TAT
40heparin45 29 24 1111.5CCR3, ITIH4, PLAUR, TAT
41cycloheximide458.5B2M, ITIH4, PLAUR, TAT
42butyrate458.4TAT, PLAUR, CCR3, B2M
43serine458.4TAT, PLAUR, ITIH4, B2M
44genistein45 29 61 3 24 1113.4TAT, PLAUR, CCR3, B2M
45oxygen45 249.4TAT, PLAUR, CCR3
46tyrosine458.4CCR3, ITIH4, PLAUR, TAT
47retinoic acid45 249.4TAT, PLAUR, CCR3, B2M
48estrogen458.2TAT, PLAUR, B2M
49alanine458.0TAT, PLAUR, ITIH4, CCR3, B2M
50cysteine458.0B2M, CCR3, ITIH4, PLAUR, TAT

GO Terms for genes affiliated with Aids Dementia Complex

About this section
Sources:
16Gene Ontology
See all sources

Cellular components related to Aids Dementia Complex according to GeneCards/GeneDecks:

idNameGO IDScoreTop Affiliating Genes
1endoplasmic reticulum lumenGO:0057889.1PLAUR, B2M

Biological processes related to Aids Dementia Complex according to GeneCards/GeneDecks:

idNameGO IDScoreTop Affiliating Genes
1chemotaxisGO:0069359.1PLAUR, CCR3

Products for genes affiliated with Aids Dementia Complex

About this section
  • Antibodies
  • Proteins
  • Lysates
  • Antibodies

Sources for Aids Dementia Complex

About this section
4CDC
13ExPASy
14FMA
22GTR
23HGMD
24HMDB
25ICD10
26ICD10 via Orphanet
27ICD9CM
29IUPHAR
30KEGG
35MeSH
36MESH via Orphanet
37MGI
40NCIt
41NDF-RT
44NINDS
45Novoseek
47OMIM
48OMIM via Orphanet
52PubMed
53QIAGEN
59SNOMED-CT via Orphanet
62UMLS
63UMLS via Orphanet