ADC
MCID: ADS004
MIFTS: 39

Aids Dementia Complex (ADC) malady

Categories: Rare diseases, Mental diseases

Aliases & Classifications for Aids Dementia Complex

Aliases & Descriptions for Aids Dementia Complex:

Name: Aids Dementia Complex 50 52 69
Aids Related Cognitive Impairment 50
Adc 50

Classifications:



Summaries for Aids Dementia Complex

MalaCards based summary : Aids Dementia Complex, also known as aids related cognitive impairment, is related to leukoencephalopathy with ataxia and adenosquamous cell lung carcinoma. An important gene associated with Aids Dementia Complex is CXCL12 (C-X-C Motif Chemokine Ligand 12), and among its related pathways/superpathways are Akt Signaling and PAK Pathway. The drugs Dopamine and Methylphenidate have been mentioned in the context of this disorder. Affiliated tissues include brain, testes and t cells, and related phenotypes are cellular and hematopoietic system

Related Diseases for Aids Dementia Complex

Diseases related to Aids Dementia Complex via text searches within MalaCards or GeneCards Suite gene sharing:

(show top 50) (show all 57)
id Related Disease Score Top Affiliating Genes
1 leukoencephalopathy with ataxia 10.8
2 adenosquamous cell lung carcinoma 10.8
3 dementia 10.8
4 hiv-1 10.3
5 spondylometaphyseal dysplasia east-african type 10.2 B2M TNF
6 glucose intolerance 10.2 B2M TNF
7 childhood pleomorphic rhabdomyosarcoma 10.2 B2M TNF
8 primary ciliary dyskinesia 10.2 B2M TNF
9 hereditary alpha tryptasemia syndrome 10.2 B2M TNF
10 plummer's disease 10.1 B2M TNF
11 osteodysplasty precocious of danks mayne and kozlowski 10.1 CCR3 TNF
12 crohn's colitis 10.1 CCR3 TNF
13 sacrococcygeal teratoma 10.1 CXCL12 TNF
14 oppositional defiant disorder 10.1 CXCL12 TNF
15 cockayne syndrome 10.1 B2M TNF
16 conjunctival concretion 10.1 CCR3 TNF
17 morbid obesity 10.0 CXCR4 TNF
18 sclerosing adenosis of breast 10.0 B2M TNF
19 spontaneous ocular nystagmus 10.0 CCR3 TNF
20 biliary cirrhosis, primary, 2 10.0 B2M TNF
21 ovarian mucinous adenocarcinoma 10.0 ITIH4 TNF
22 encephalopathy 10.0
23 islet cell tumor 10.0 CXCL12 CXCR4
24 cranial nerve palsy 10.0 B2M TNF
25 xeroderma pigmentosum, group b 10.0 CXCL12 CXCR4
26 chronic cervicitis 10.0 CXCL12 CXCR4
27 rhabdomyosarcoma 10.0 CXCL12 CXCR4
28 neuronitis 10.0
29 central nervous system leiomyosarcoma 9.9 CXCL12 CXCR4
30 granuloma inguinale 9.9 CXCL12 CXCR4
31 anterior foramen magnum meningioma 9.9 B2M ITIH4 TNF
32 autosomal recessive congenital methemoglobinemia 9.9 CCR3 CXCR4
33 sarcoma 9.9
34 cerebritis 9.9
35 kcnq3-related disorders 9.9 CXCR4 ITIH4
36 pulmonary fibrosis, idiopathic 9.8 B2M CXCL12 CXCR4
37 acquired immunodeficiency syndrome 9.8
38 human herpesvirus 8 9.8
39 exophthalmos 9.8 CXCR4 ITIH4 TNF
40 cranioectodermal dysplasia 1 9.8 CXCL12 CXCR4 TNF
41 cutis laxa, autosomal recessive, type ib 9.7 B2M CXCL12 CXCR4 TNF
42 cocaine abuse 9.7
43 chronic fatigue syndrome 9.7
44 schizophrenia 9.7
45 encephalitis 9.7
46 toxoplasmosis 9.7
47 cerebral atrophy 9.7
48 brain injury 9.7
49 myoclonus 9.7
50 hydrocephalus 9.7

Graphical network of the top 20 diseases related to Aids Dementia Complex:



Diseases related to Aids Dementia Complex

Symptoms & Phenotypes for Aids Dementia Complex

MGI Mouse Phenotypes related to Aids Dementia Complex:

44
id Description MGI Source Accession Score Top Affiliating Genes
1 cellular MP:0005384 9.8 B2M CCR3 CXCL12 CXCR4 ITIH4 TNF
2 hematopoietic system MP:0005397 9.65 B2M CCR3 CXCL12 CXCR4 TNF
3 immune system MP:0005387 9.55 B2M CCR3 CXCL12 CXCR4 TNF
4 liver/biliary system MP:0005370 9.26 CXCL12 ITIH4 TNF B2M
5 neoplasm MP:0002006 8.92 B2M CXCR4 ITIH4 TNF

Drugs & Therapeutics for Aids Dementia Complex

Drugs for Aids Dementia Complex (from DrugBank, HMDB, Dgidb, PharmGKB, IUPHAR, NovoSeek, BitterDB):

(show top 50) (show all 123)
id Name Status Phase Clinical Trials Cas Number PubChem Id
1
Dopamine Approved Phase 4,Phase 3,Phase 2 51-61-6, 62-31-7 681
2
Methylphenidate Approved, Investigational Phase 4,Phase 3 113-45-1 4158
3
Ritonavir Approved, Investigational Phase 4,Phase 2,Phase 3 155213-67-5 392622
4
Lopinavir Approved Phase 4,Phase 2,Phase 3 192725-17-0 92727
5
Darunavir Approved Phase 4,Phase 2,Phase 3 635728-49-3, 206361-99-1 213039
6
Dextroamphetamine Approved, Illicit Phase 4 51-64-9 5826
7
Epinephrine Approved, Vet_approved Phase 4 51-43-4 5816
8
Formaldehyde Approved, Vet_approved Phase 4 50-00-0 712
9
Cobicistat Approved Phase 4 1004316-88-4
10 Neurotransmitter Agents Phase 4,Phase 3,Phase 2
11 Neurotransmitter Uptake Inhibitors Phase 4,Phase 3
12 Dopamine Agents Phase 4,Phase 3,Phase 2
13 Dopamine Uptake Inhibitors Phase 4,Phase 3
14 Anti-HIV Agents Phase 4,Phase 3,Phase 2,Phase 1
15 Central Nervous System Stimulants Phase 4,Phase 3
16 Dopamine agonists Phase 4
17
protease inhibitors Phase 4,Phase 2,Phase 3,Phase 1
18 HIV Protease Inhibitors Phase 4,Phase 2,Phase 3,Phase 1
19 Cytochrome P-450 CYP3A Inhibitors Phase 4,Phase 2,Phase 3
20 Cytochrome P-450 Enzyme Inhibitors Phase 4,Phase 2,Phase 3
21 Pharmaceutical Solutions Phase 4,Phase 2,Phase 1
22 Hypolipidemic Agents Phase 4
23 Anti-Infective Agents Phase 4,Phase 3,Phase 2,Phase 1
24 Lipid Regulating Agents Phase 4
25 Antimetabolites Phase 4,Phase 3,Phase 2,Phase 1
26 Anti-Retroviral Agents Phase 4,Phase 3,Phase 2,Phase 1
27 Antiviral Agents Phase 4,Phase 3,Phase 2,Phase 1
28 Calcium, Dietary Phase 4,Phase 1
29 Vasoconstrictor Agents Phase 4
30 Epinephryl borate Phase 4
31 Racepinephrine Phase 4
32 Atorvastatin Calcium Phase 4 134523-03-8
33 Hydroxymethylglutaryl-CoA Reductase Inhibitors Phase 4
34 Anticholesteremic Agents Phase 4
35
Saquinavir Approved, Investigational Phase 2, Phase 3 127779-20-8 60787
36
Amprenavir Approved Phase 2, Phase 3 161814-49-9 65016
37
Nelfinavir Approved Phase 2, Phase 3 159989-64-7 64143
38
Efavirenz Approved, Investigational Phase 2, Phase 3 154598-52-4 64139
39
Nevirapine Approved Phase 2, Phase 3 129618-40-2 4463
40
Zidovudine Approved Phase 3,Phase 2,Phase 1 30516-87-1 35370
41
Tenofovir Approved, Investigational Phase 2, Phase 3 147127-20-6 464205
42
Lamivudine Approved, Investigational Phase 2, Phase 3,Phase 1 134678-17-4 60825
43
Stavudine Approved, Investigational Phase 3 3056-17-5 18283
44
Abacavir Approved, Investigational Phase 3,Phase 2 136470-78-5 65140 441300
45
Maraviroc Approved, Investigational Phase 2, Phase 3 376348-65-1 3002977
46
Enfuvirtide Approved, Investigational Phase 2, Phase 3 159519-65-0 16130199
47
Etravirine Approved Phase 2, Phase 3 269055-15-4 193962
48
Tipranavir Approved, Investigational Phase 2, Phase 3 174484-41-4 65027
49
Delavirdine Approved Phase 2, Phase 3 136817-59-9 5625
50
Emtricitabine Approved, Investigational Phase 2, Phase 3 143491-57-0 60877

Interventional clinical trials:

(show top 50) (show all 61)
id Name Status NCT ID Phase
1 Apathy Associated With Alzheimer's Disease Completed NCT00254033 Phase 4
2 Trial of a Pharmacist-physician Intervention Model to Reduce High-risk Drug Use by Hospitalised Elderly Patients Completed NCT02570945 Phase 4
3 SOLFAMU Study of Nasal Brushing Collected OLFActory MUcosa Samples in the Diagnosis of Human Encephalopathies Recruiting NCT02951559 Phase 4
4 Modulation of Monocyte Activation by Atorvastatin in HIV Infection Active, not recruiting NCT01263938 Phase 4
5 Downmodulating Monocyte Activation for HIV-1 Associated Neurocognitive Disorders (HAND) Active, not recruiting NCT01600170 Phase 4
6 Effect of Cobicistat Versus Ritonavir Boosting on the Brain Permeation of Darunavir in HIV-infected Individuals Terminated NCT02503462 Phase 4
7 HIV - Monotherapy in Switzerland (MOST-ch) Terminated NCT00531986 Phase 4
8 A Study Comparing Long-acting Methylphenidate (ConcertaTM) vs. Placebo in the Treatment of Memory Loss Due to HIV Unknown status NCT01599975 Phase 3
9 A Multicenter Placebo-Controlled Double-Blind Trial to Evaluate Azidothymidine (AZT) Treatment of the AIDS Dementia Complex and Central Nervous System (CNS) Human Immunodeficiency Virus (HIV) Infection Completed NCT00000702 Phase 3
10 A Study to Evaluate the Use of Stavudine (d4T) to Treat AIDS Dementia Complex Completed NCT00002246 Phase 3
11 An Open Trial of Zidovudine (AZT) Treatment of the AIDS Dementia Complex in Patients With AIDS or Low CD4+ Lymphocyte Counts Completed NCT00000709 Phase 3
12 A Phase III, Randomized, Double-Blind, Multicentre Study to Evaluate the Safety and Efficacy of 1592U89 in Patients With AIDS Dementia Complex Completed NCT00002163 Phase 3
13 Clinical Trial of CNS-targeted HAART (CIT2) Completed NCT00624195 Phase 2, Phase 3
14 Maraviroc and NeuroAIDS Pathogenesis Recruiting NCT02159027 Phase 2, Phase 3
15 Safety and Effectiveness of Giving CPI-1189 to HIV-Infected Patients With AIDS Dementia Unknown status NCT00002414 Phase 2
16 Comparison of 2',3'-Dideoxyinosine (Didanosine, ddI) and Zidovudine in Therapy of Patients With the AIDS Dementia Complex Completed NCT00000657 Phase 2
17 A Study to Evaluate the Use of Memantine In Combination With Anti-HIV Drugs to Treat AIDS Dementia Complex (ADC) Completed NCT00000867 Phase 2
18 Effect of Cenicriviroc on HIV Neurocognitive Impairment Completed NCT02128828 Phase 2
19 A Study of Thioctic Acid and Deprenyl in HIV-Infected Patients With Dementia Completed NCT00002154 Phase 2
20 Safety and Effectiveness of the Selegiline "Patch" for Decreased Mental Function in HIV Patients Completed NCT00013585 Phase 2
21 FluoroAv45 Imaging Research-in Alzheimer's Disease Completed NCT01325259 Phase 2
22 Effects of Delivery Mode of Cognition Intervention in Early Alzheimer's Disease Completed NCT00611312 Phase 2
23 Ferumoxytol-enhanced Imaging and Mapping in neuroAIDS Recruiting NCT02678767 Phase 2
24 Intranasal Insulin for the Treatment of HAND Recruiting NCT03081117 Phase 1, Phase 2
25 Minocycline for HIV+ Cognitive Impairment in Uganda Terminated NCT00855062 Phase 1, Phase 2
26 Randomized, Double-Blind, Placebo-Controlled Trial of Nimodipine for the Neurological Manifestations of HIV-1 Completed NCT00000738 Phase 1
27 Safety and Effectiveness of CPI-1189 in HIV-Infected Males on Combination Anti-HIV Drug Therapy Completed NCT00002209 Phase 1
28 Parallel Group, Placebo-Controlled, Tolerability, Safety, and Efficacy Study of OPC-14117 in HIV Dementia Completed NCT00002148 Phase 1
29 Ferumoxytol-enhanced Brain MRI in HIV-associated Neurocognitive Disorders Completed NCT01665846 Phase 1
30 A Prospective Observational Trial to Determine Cardiovascular Diseases in HIV-infected Patients Unknown status NCT02291081
31 A Pilot Study To Evaluate the Effect of Retrovir (Zidovudine: AZT) in the Treatment of Human Immunodeficiency Virus (HIV) Associated Dementia and Neuromuscular Diseases Completed NCT00002044
32 HIV-1 Specific Immune Responses in Thai Individuals With HIV Dementia Completed NCT00777426
33 The Prevalence of Neurocognitive Disorder in a Primary Care-based HIV Cohort Compared to a HIV-negative Control Cohort - Completed NCT01434563
34 A Third-Party Blinded, Placebo Controlled Comparative Study of AS-101 Administered Intravenously in HIV Positive Patients With Advanced Disease Completed NCT00002033
35 A Study of Decreased Mental Function Associated With HIV Completed NCT00027040
36 Neurocognitive Impairment and Psychiatric Comorbidities in HIV-1 Completed NCT00476671
37 Treatment of AIDS and AIDS Related Complex. Part-1- Treatment of Patients With ARC (AZT Vs. Placebo) Completed NCT00002063
38 A Randomized Controlled Trial of Using Video Images in Dementia Completed NCT00704886
39 Outcome Predictors of a Cognitive Intervention in aMCI Completed NCT01525368
40 ThinkingFit: Combined Physical, Cognitive and Social Treatment in Mild Cognitive Impairment (MCI) Completed NCT01603862
41 Evaluation of "My Tools 4 Care" for Family Caregivers of Persons With Dementia Completed NCT02428387
42 Blood-brain Barrier Quantification in Cerebral Small Vessel Disease Completed NCT02033291
43 Interaction of Cobalamin Status With Nitrous Oxide in Relation to Postoperative Cognitive Changes in the Elderly Completed NCT00212147
44 Evaluation of the Role of OCT in the Detection of HIV-associated Neurocognitive Disorder Recruiting NCT02431091
45 Elderly CAncer Patient Recruiting NCT02884375
46 Determinants of Quality Of Life in AGEd Cancer Patients Recruiting NCT02672657
47 Amyloid Plaque Deposition in Chemotherapy-Induced Cognitive Impairment Recruiting NCT02317783
48 Beta Testing of a New Assessment in Huntington's Disease (HD) Recruiting NCT03119246
49 Understanding Hallucinations (Part II) Recruiting NCT02460965
50 In Vivo Alzheimer Proteomics Recruiting NCT02263235

Search NIH Clinical Center for Aids Dementia Complex

Genetic Tests for Aids Dementia Complex

Anatomical Context for Aids Dementia Complex

MalaCards organs/tissues related to Aids Dementia Complex:

39
Brain, Testes, T Cells, Cortex

Publications for Aids Dementia Complex

Articles related to Aids Dementia Complex:

(show top 50) (show all 188)
id Title Authors Year
1
Development and in vivo evaluation of an implantable nano-enabled multipolymeric scaffold for the management of AIDS dementia complex (ADC). ( 26456249 )
2015
2
Effects of HIV-1 tat on secretion of TNF-I+ and IL-1I^ by U87 cells in AIDS patients with or without AIDS dementia complex. ( 24625401 )
2014
3
CNS toxoplasmosis induced hydrocephalus revisited and a brief review of AIDS dementia complex. ( 23749026 )
2013
4
What's in a name? AIDS dementia complex, HIV-associated dementia, HIV-associated neurocognitive disorder or HIV encephalopathy. ( 22722724 )
2012
5
Formulation development and in vitro evaluation of didanosine-loaded nanostructured lipid carriers for the potential treatment of AIDS dementia complex. ( 20923388 )
2011
6
HIV-1B gp120 genes from one patient with AIDS dementia complex can affect the secretion of tumor necrosis factor and interleukin 1I^ in glial cells. ( 22340390 )
2011
7
Memantine for AIDS dementia complex: open-label report of ACTG 301. ( 20400412 )
2010
8
Validity of the CogState brief battery: relationship to standardized tests and sensitivity to cognitive impairment in mild traumatic brain injury, schizophrenia, and AIDS dementia complex. ( 19395350 )
2009
9
High level HIV-1 DNA concentrations in brain tissues differentiate patients with post-HAART AIDS dementia complex or cardiovascular disease from those with AIDS. ( 19641870 )
2009
10
[Analysis of genetic diversity and biological functional site of HIV-1 gp120 from a patient with AIDS dementia complex]. ( 19634757 )
2009
11
Prevalence of AIDS dementia complex: results from a statewide population-based registry of Alzheimer's disease and related disorders. ( 19058735 )
2008
12
Communication impairment in the AIDS dementia complex (ADC): a case report. ( 18242630 )
2008
13
Adjunctive therapies for AIDS dementia complex. ( 18646159 )
2008
14
AIDS dementia complex and Hashimoto encephalopathy in a senescent woman. ( 18033678 )
2007
15
Cerebrospinal fluid markers in central nervous system HIV infection and AIDS dementia complex. ( 18808988 )
2007
16
Factors in AIDS dementia complex trial design: results and lessons from the abacavir trial. ( 17401456 )
2007
17
AIDS dementia complex. ( 18808977 )
2007
18
Proton MRS and neuropsychological correlates in AIDS dementia complex: evidence of subcortical specificity. ( 17827413 )
2007
19
SV40 and HIV sequences in the cerebrospinal fluid of a patient with AIDS dementia complex. ( 17504176 )
2007
20
AIDS dementia complex in China. ( 17070055 )
2007
21
Elevated cerebrospinal fluid neurofilament light protein concentrations predict the development of AIDS dementia complex. ( 17492593 )
2007
22
Timed Gait test: normative data for the assessment of the AIDS dementia complex. ( 16840235 )
2006
23
AIDS dementia complex. ( 16909695 )
2006
24
The assessment of cognitive function in advanced HIV-1 infection and AIDS dementia complex using a new computerised cognitive test battery. ( 16343841 )
2006
25
Editorial comment: AIDS dementia complex in the current era. ( 17152650 )
2006
26
Quinolinic acid selectively induces apoptosis of human astrocytes: potential role in AIDS dementia complex. ( 16042813 )
2005
27
CSF amyloid beta42 and tau levels correlate with AIDS dementia complex. ( 16275845 )
2005
28
The AIDS dementia complex: clinical and basic neuroscience with implications for novel molecular therapies. ( 16260383 )
2005
29
Involvement of quinolinic acid in AIDS dementia complex. ( 15639803 )
2005
30
HAART & the molecular biology of AIDS dementia complex. ( 15817943 )
2005
31
Inflammation and neuroaxonal injury in multiple sclerosis and AIDS dementia complex: implications for neuroprotective treatment. ( 16138246 )
2005
32
Undetectable cerebrospinal fluid HIV RNA and beta-2 microglobulin do not indicate inactive AIDS dementia complex in highly active antiretroviral therapy-treated patients. ( 16010165 )
2005
33
Olfactory deficits in HIV-infected patients with and without AIDS dementia complex. ( 14984801 )
2004
34
Regional patterns of brain metabolites in AIDS dementia complex. ( 15528093 )
2004
35
Evidence for a change in AIDS dementia complex in the era of highly active antiretroviral therapy and the possibility of new forms of AIDS dementia complex. ( 15075501 )
2004
36
The urokinase receptor is overexpressed in the AIDS dementia complex and other neurological manifestations. ( 15122709 )
2004
37
Chemokine receptors, neural progenitor cells, and the AIDS dementia complex. ( 15216453 )
2004
38
A multi-center 1H MRS study of the AIDS dementia complex: validation and preliminary analysis. ( 12766890 )
2003
39
SDF-1alpha is expressed in astrocytes and neurons in the AIDS dementia complex: an in vivo and in vitro study. ( 12834106 )
2003
40
Cytokines and AIDS dementia complex. ( 12478083 )
2003
41
Involvement of dopamine in the progression of AIDS Dementia Complex. ( 11956960 )
2002
42
Clinical aspects of the AIDS dementia complex in relation to histopathological and immunohistochemical variables. ( 11914551 )
2002
43
Screening for the AIDS dementia complex. ( 11862659 )
2002
44
Kaposi's sarcoma and human herpesvirus 8 infection do not protect HIV-1 infected homosexual men from AIDS dementia complex. ( 11684936 )
2001
45
Elevated levels of soluble Fas and Fas ligand in cerebrospinal fluid of patients with AIDS dementia complex. ( 11240032 )
2001
46
Transforming growth factor beta-1 and interferon-alpha in the AIDS dementia complex (ADC): possible relationship with cerebral viral load? ( 11282546 )
2001
47
HIV-1 reverse transcriptase sequence in plasma and cerebrospinal fluid of patients with AIDS dementia complex treated with Abacavir. ( 11371689 )
2001
48
Varied tropism of HIV-1 isolates derived from different regions of adult brain cortex discriminate between patients with and without AIDS dementia complex (ADC): evidence for neurotropic HIV variants. ( 11162807 )
2001
49
Markers of AIDS dementia complex: the role of cerebrospinal fluid assays. ( 11579253 )
2001
50
Cerebrospinal fluid S-100beta and its relationship with AIDS dementia complex. ( 11564589 )
2001

Variations for Aids Dementia Complex

Expression for Aids Dementia Complex

Search GEO for disease gene expression data for Aids Dementia Complex.

Pathways for Aids Dementia Complex

Pathways related to Aids Dementia Complex according to GeneCards Suite gene sharing:

(show all 16)
id Super pathways Score Top Affiliating Genes
1
Show member pathways
12.97 CCR3 CXCL12 CXCR4 TNF
2
Show member pathways
12.77 CCR3 CXCL12 CXCR4 TNF
3
Show member pathways
12.49 CCR3 CXCL12 CXCR4
4
Show member pathways
12.3 B2M CXCL12 CXCR4 TNF
5 11.53 CXCL12 TNF
6 11.49 CXCL12 TNF
7
Show member pathways
11.42 CCR3 CXCL12 CXCR4
8 11.42 B2M CXCL12 CXCR4 TNF
9 11.39 CXCL12 CXCR4
10 11.32 CXCL12 CXCR4
11 11.29 CXCL12 CXCR4
12 11.26 CCR3 TNF
13
Show member pathways
11.22 B2M TNF
14 11.05 CXCL12 CXCR4
15 10.81 CXCL12 CXCR4
16 9.91 CXCL12 TNF

GO Terms for Aids Dementia Complex

Cellular components related to Aids Dementia Complex according to GeneCards Suite gene sharing:

id Name GO ID Score Top Affiliating Genes
1 plasma membrane GO:0005886 9.43 B2M CCR3 CXCL12 CXCR4 ITIH4 TNF
2 cell surface GO:0009986 9.33 B2M CXCR4 TNF
3 external side of plasma membrane GO:0009897 8.8 B2M CXCL12 TNF

Biological processes related to Aids Dementia Complex according to GeneCards Suite gene sharing:

id Name GO ID Score Top Affiliating Genes
1 immune response GO:0006955 9.61 B2M CXCL12 TNF
2 inflammatory response GO:0006954 9.5 CCR3 CXCR4 TNF
3 defense response to Gram-positive bacterium GO:0050830 9.4 B2M TNF
4 positive regulation of endothelial cell proliferation GO:0001938 9.37 CCR3 CXCL12
5 chemotaxis GO:0006935 9.33 CCR3 CXCL12 CXCR4
6 positive regulation of cell adhesion GO:0045785 9.26 CXCL12 TNF
7 response to virus GO:0009615 9.13 CXCL12 CXCR4 TNF
8 chemokine-mediated signaling pathway GO:0070098 8.8 CCR3 CXCL12 CXCR4

Molecular functions related to Aids Dementia Complex according to GeneCards Suite gene sharing:

id Name GO ID Score Top Affiliating Genes
1 chemokine receptor activity GO:0004950 8.96 CCR3 CXCR4
2 C-C chemokine binding GO:0019957 8.62 CCR3 CXCR4

Sources for Aids Dementia Complex

3 CDC
7 CNVD
9 Cosmic
10 dbSNP
11 DGIdb
16 ExPASy
18 FMA
28 GO
29 GTR
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32 HPO
33 ICD10
34 ICD10 via Orphanet
35 ICD9CM
36 IUPHAR
37 KEGG
38 LifeMap
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42 MeSH
43 MESH via Orphanet
44 MGI
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54 OMIM
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70 UMLS via Orphanet
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