Aids Dementia Complex malady

Wikipedia: AIDS dementia complex (ADC; also known as HIV dementia, HIV encephalopathy, HIV-associated dementia and...⁴⁴ more...

MalaCards: Aids Dementia Complex, also known as aids related cognitive impairment, is related to multiple sclerosis and malaria. An important gene associated with Aids Dementia Complex is B2M (beta-2-microglobulin), and among its related pathways are Amoebiasis and Antigen processing and presentation. The compounds ivig and bicyclam have been mentioned in the context of this disorder. Affiliated tissues include brain, monocytes and t cells, and related mouse phenotypes are hematopoietic system and respiratory system.

aids dementia complex 30 32 43 aids related cognitive impairment 30

adc 30

Diseases related to aids dementia complex by text searches and GeneDecks gene sharing:

(show top 50)    (show all 595)

id	Related Disease	Score	Top Affiliating Genes
1	multiple sclerosis	29.8	IL1B, MBP, CCR5, IFNG, CXCR4
2	malaria	28.9	IL10, IFNG, TNF, NOS2
3	non-small cell lung carcinoma	27.9	CD27, IL10, IL1B, TNF, PLAUR, NOS2
4	spinal cord injury	26.6	BDNF, IL10, IL1B, MBP, IFNG, TPPP3
5	lung carcinoma	25.9	CD27, IL10, IL1B, IFNG, TNF, PLAUR
6	dementia	25.1	NCOA6, BDNF, S100B, B2M, CD27, CD4
7	neuronitis	22.8	BDNF, S100B, CD4, ITIH4, IL10, IL1B
8	hypertension	22.6	BDNF, S100B, B2M, IL10, IL1B, MBP
9	carcinoma	21.5	BDNF, S100B, B2M, CD27, CD4, CD9
10	alzheimer's disease	21.3	BDNF, S100B, ITIH4, IL10, IL1B, MBP
11	hepatitis	20.8	NCOA6, BDNF, S100B, B2M, CD27, CD4
12	prostatitis	20.2	NCOA6, BDNF, S100B, B2M, CD4, CD9
13	breast cancer	20.0	NCOA6, BDNF, S100B, B2M, CD27, CD4
14	aids, resistance to	13.7	CCR5, CXCL12
15	progressive multifocal leukoencephalopathy	13.6	MBP, TAT
16	central nervous system leukemia	13.6	IL1B, TNF
17	retinal hemangioblastoma	13.6	CXCL12, CXCR4
18	corneal ulcer	13.6	IL1B, CCR3, TAT
19	fissured tongue	13.5	IL1B, TNF
20	amphetamine abuse	13.5	IVD, SLC6A3
21	erythema multiforme	13.5	CCR3, TNF, CXCR4
22	chronic myeloproliferative disease	13.5	B2M, IL1B, CXCL12
23	myelokathexis	13.5	CXCL12, CXCR4
24	parametritis	13.4	TNF, TAT, SLC6A3
25	arthritis	13.4	IL1B, TNF, PLAUR
26	staphylococcal toxic shock syndrome	13.4	IL1B, TNF
27	herpes gestationis	13.4	ITIH4, MBP, TAT
28	endotoxin hyporesponsiveness	13.4	IL1B, TNF
29	memory impairment	13.4	BDNF, ITIH4, SLC6A3
30	cocaine abuse	13.4	BDNF, MBP, SLC6A3
31	opiate dependence	13.4	TNF, NOS2, SLC6A3
32	central nervous system disease	13.3	IL1B, CCR5, PLAUR, NOS2
33	toxic epidermal necrolysis	13.3	CCR3, TNF, NOS2, CXCR4
34	stevens-johnson syndrome	13.3	CCR3, TNF, NOS2, CXCR4
35	oral submucous fibrosis	13.3	IL1B, TNF, NOS2
36	tuberculous uveitis	13.3	IFNG, TNF
37	prostate disease	13.3	PLAUR, CXCL12, CXCR4
38	heart block	13.2	TNF, PLAUR, NOS2
39	syphilis	13.2	B2M, CD4, CCR5
40	chronic inflammatory demyelinating polyradiculoneuropathy	13.2	MBP, IFNG, CXCL12
41	erdheim-chester disease	13.2	S100B, IL1B, CCR5, CCR3
42	substance dependence	13.2	BDNF, NOS2, SLC6A3
43	periventricular leukomalacia	13.2	IL1B, MBP, TNF, NOS2, SLC1A2
44	leukomalacia	13.2	IL1B, MBP, TNF, NOS2, SLC1A2
45	punctate inner choroidopathy	13.2	IL10, TNF
46	burkitt's lymphoma	13.1	CD27, CCR3, TAT, CXCR4
47	usual interstitial pneumonia	13.1	IFNG, CXCL12, CXCR4
48	aicardi-goutieres syndrome	13.1	CD4, ITIH4, MBP, TAT
49	meningoencephalitis	13.1	B2M, CD4, MBP, TNF
50	lymphoproliferative syndrome	13.1	B2M, CD4, CCR5, CCR3

Approved drugs:

Drug clinical trials:

MalaCards organs/tissues related to aids dementia complex:

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MGI Mouse Phenotypes related to aids dementia complex:

²⁵ (show all 19)

id	Description	MGI Source Accession	Score	Top Affiliating Genes
1	hematopoietic system phenotype	MP:0005397	10.4	CD27, CCR3
2	respiratory system phenotype	MP:0005388	10.3	BDNF
3	endocrine/exocrine gland phenotype	MP:0005379	10.0	IFNG
4	skeleton phenotype	MP:0005390	9.7	CD9, F2RL1, CXCR4
5	immune system phenotype	MP:0005387	9.0	IFNG, PLAUR, MBP, CD9, CD4, TNF
6	no phenotypic analysis	MP:0003012	8.9	F2RL1, CCR5, CD4, BDNF
7	liver/biliary system phenotype	MP:0005370	8.7	SOD1, ITIH4, CCR5, IFNG, NCOA6
8	reproductive system phenotype	MP:0005389	8.5	CCR5, IL10, IFNG, TNF, NOS2, SLC6A3
9	tumorigenesis	MP:0002006	8.4	IFNG, CCR5, IL1B, IL10, ITIH4, F2RL1
10	digestive/alimentary phenotype	MP:0005381	8.3	IFNG, NOS2, CCR5, CD4, B2M, BDNF
11	nervous system phenotype	MP:0003631	8.2	CXCL12, BDNF, CD4, PLAUR, CXCR4, SLC6A3
12	integument phenotype	MP:0010771	8.1	IFNG, CD4, NCOA6, BDNF, S100B, SLC6A3
13	mortality/aging	MP:0010768	7.8	BDNF, CD4, SLC1A2, NOS2, CCR5, IL1B
14	vision/eye phenotype	MP:0005391	7.3	IL10, MBP, CCR5, IFNG, TNF, NOS2
15	muscle phenotype	MP:0005369	7.3	NOS2, NCOA6, IL10, IFNG, TNF, PLAUR
16	homeostasis/metabolism phenotype	MP:0005376	7.1	SOD1, F2RL1, BDNF, B2M, CD4, MBP
17	cardiovascular system phenotype	MP:0005385	6.8	IFNG, CCR5, IL1B, IL10, NCOA6, B2M
18	behavior/neurological phenotype	MP:0005386	6.6	PLAUR, F2RL1, NOS2, SOD1, SLC6A3, SLC1A2
19	cellular phenotype	MP:0005384	5.5	IL10, TNF, F2RL1, IFNG, CCR3, CCR5

Articles related to aids dementia complex:

(show all 21)

id	Title	Authors	Year	Affiliating Genes
1	Analysis of genetic diversity and biological functio nal site of HIV-1 gp120 from a patient with AIDS dementia complex (19634757)	Yan Y.F.... Xu H.Z.	2009	ITIH4
2	Factors in AIDS dementia complex trial design: results and lessons from the abacavir trial. (17401456)	Brew B.J.... Romero C.	2007	F2RL1
3	Undetectable cerebrospinal fluid HIV RNA and beta-2 microglobulin do not indicate inactive AIDS dementia complex in highly active antiretroviral therapy-treated patients. (16010165)	Cysique L.A.... Romero C.	2005	B2M
4	The urokinase receptor is overexpressed in the AIDS dementia complex and other neurological manifestations. (15122709)	Cinque P.... Sidenius N.	2004	PLAUR
5	SDF-1alpha is expressed in astrocytes and neurons in the AIDS dementia complex: an in vivo and in vitro study. (12834106)	Rostasy K.... Navia B.A.	2003	CXCR4, CXCL12
6	Potential role of CCR5 polymorphism in the development of AIDS dementia complex. (10575135)	Boven L.A.... Nottet H.S.	1999	CCR5
7	Increased peroxynitrite activity in AIDS dementia complex: implications for the neuropathogenesis of HIV-1 infection. (10201964)	Boven L.A.... Nottet H.S.	1999	SOD1, IL1B, NOS2
8	Overexpression of nerve growth factor and basic fibroblast growth factor in AIDS dementia complex. (10408969)	Boven L.A.... Nottet H.S.	1999	BDNF
9	Anomalies in Nef expression within the central nervous system of HIV-1 positive individuals/AIDS patients with or without AIDS dementia complex. (9639072)	McPhee D.A.... Brew B.J.	1998	S100B
10	Tumor necrosis factor-alpha, microglia and astrocytes in AIDS dementia complex. (9144590)	Seilhean D.... Hauw J.J.	1997	TNF
11	Predictive markers of AIDS dementia complex: CD4 cell count and cerebrospinal fluid concentrations of beta 2-microglobulin and neopterin. (8699058)	Brew B.J.... Kaldor J.	1996	B2M
12	Review of antiretroviral therapy in the prevention of HIV-related AIDS dementia complex (ADC). (7614899)	Portegies P.	1995	CD9
13	Biochemical studies on AIDS dementia complex--possib le contribution of quinolinic acid during brain damage (7474452)	Saito K.	1995	IFNG
14	Evaluation of autoantibodies to brain proteins in patients with AIDS dementia complex. (8301522)	Trujillo J.R.... Essex M.	1994	TPPP3
15	Low levels of specific T cell activation marker CD27 accompanied by elevated levels of markers for non-specific immune activation in the cerebrospinal fluid of patients with AIDS dementia complex. (8227320)	Portegies P.... Goudsmit J.	1993	TNF, CD27
16	Cerebrospinal fluid beta 2-microglobulin in patients with AIDS dementia complex: an expanded series including response to zidovudine treatment. (1616651)	Brew B.J.... Price R.W.	1992	B2M
17	Cerebrospinal fluid myelin basic protein in AIDS dementia complex: relationship to disease progression and zidovudine treatment. (1281644)	Mastroianni C.M.... Riccio P.	1992	MBP
18	Cerebrospinal fluid myelin basic protein as predictive marker of demyelination in AIDS dementia complex. (1370671)	Liuzzi G.M.... Riccio P.	1992	MBP
19	Cerebrospinal fluid cytokines in AIDS dementia complex. (1403021)	Perrella O.... Soscia M.	1992	TNF
20	Cerebrospinal fluid beta-2-microglobulin in multiple sclerosis and AIDS dementia complex. (1355285)	Carrieri P.B.... Perrella O.	1992	B2M
21	Detection of cerebrospinal fluid antibodies against myelin basic protein in patients with AIDS dementia complex. (1720316)	Mastroianni C.M.... Riccio P.	1991	MBP

Genes related to aids dementia complex according to GeneCards:

(show all 29)

id	Symbol	Description	Score	GeneCards Section Context
1	B2M	beta-2-microglobulin	11.0	Publications
2	MBP	myelin basic protein	11.0	Publications
3	ITIH4	inter-alpha-trypsin inhibitor heavy chain family, member 4	11.0	Publications
4	PLAUR	plasminogen activator, urokinase receptor	11.0	Publications
5	SLC1A2	solute carrier family 1 (glial high affinity glutamate transporter), member 2	11.0
6	TAT	tyrosine aminotransferase	11.0
7	CCR3	chemokine (C-C motif) receptor 3	11.0
8	TNF	tumor necrosis factor	11.0	Publications
9	CCR5	chemokine (C-C motif) receptor 5 (gene/pseudogene)	11.0	Publications
10	NOS2	nitric oxide synthase 2, inducible	11.0	Publications
11	IL1B	interleukin 1, beta	11.0	Publications
12	BDNF	brain-derived neurotrophic factor	11.0	Publications
13	CXCR4	chemokine (C-X-C motif) receptor 4	11.0	Publications
14	CXCL12	chemokine (C-X-C motif) ligand 12	11.0	Publications
15	SLC6A3	solute carrier family 6 (neurotransmitter transporter, dopamine), member 3	11.0
16	TPPP3	tubulin polymerization-promoting protein family member 3	11.0	Publications
17	SMCR7L	Smith-Magenis syndrome chromosome region, candidate 7-like	11.0
18	IVD	isovaleryl-CoA dehydrogenase	11.0
19	CD27	CD27 molecule	11.0	Publications
20	GOLPH3	golgi phosphoprotein 3 (coat-protein)	11.0
21	CD9	CD9 molecule	11.0	Publications
22	F2RL1	coagulation factor II (thrombin) receptor-like 1	11.0	Publications
23	NCOA6	nuclear receptor coactivator 6	11.0
24	S100B	S100 calcium binding protein B	11.0	Publications
25	IL10	interleukin 10	11.0	Publications
26	CD4	CD4 molecule	11.0
27	TBC1D22A	TBC1 domain family, member 22A	11.0
28	SOD1	superoxide dismutase 1, soluble	11.0	Publications
29	IFNG	interferon, gamma	11.0	Publications

Pathways related to aids dementia complex according to GeneDecks:

(show all 44)

id	Pathway	Score	Top Affiliating Genes
1	Amoebiasis20	10.5	NOS2, IL1B
2	Antigen processing and presentation20	10.3	CD4
3	NFAT Signaling and Lymphocyte Interactions36	10.0	CD4, CXCL12
4	IL-10 Pathway36	9.9	TNF, IL10, IL1B
5	Immune response_MIF-mediated glucocorticoid regulation41	9.9	TNF, IFNG, NOS2
6	Immune response MIF-mediated glucocorticoid regulation10	9.9	NOS2, TNF, IFNG
7	Neuropeptides signaling through G-protein alpha-i & G-protein alpha-q10	9.9	CCR5, CCR3, F2RL1, CXCR4
8	Pertussis20	9.8	NOS2, TNF, IL10, IL1B
9	Immune response MIF in innate immunity response10	9.8	IFNG, TNF, IL1B, NOS2
10	Immune response_MIF in innate immunity response41	9.8	IL1B, IFNG, TNF, NOS2
11	Apoptotic Pathways Triggered By HIV136	9.8	CCR5, TNF, CXCR4, CD4
12	Molecular Mechanisms of Cancer36	9.8	CXCL12, BDNF, CCR3, CD4
13	NF-kappaB Activation by Viruses36	9.7	CXCR4, CCR5, CD4
14	Type I diabetes mellitus20	9.7	IL1B, IFNG, TNF
15	Rheumatoid arthritis20	9.7	IFNG, CXCL12, IL1B, TNF
16	MIF Mediated Glucocorticoid Regulation36	9.7	IL10, IL1B, TNF, CXCL12
17	Transcription_Role of VDR in regulation of genes involved in osteoporosis41	9.7	IFNG, IL1B, TNF
18	MIF Regulation of Innate Immune Cells36	9.6	TNF, CXCL12, IL10, IL1B
19	Hematopoietic cell lineage20	9.6	CD9, CD4, TNF, IL1B
20	PEDF Induced Signaling36	9.6	TNF, CXCL12, BDNF, IL1B, IL10
21	Intestinal immune network for IgA production20	9.6	IL10, CXCR4, CXCL12
22	Immune response_Bacterial infections in normal airways41	9.6	IFNG, NOS2, IL1B
23	Allograft rejection20	9.6	TNF, IFNG, IL10
24	Cytokine Network36	9.5	TNF, IL10, IL1B, IFNG
25	THC Differentiation Pathway36	9.5	IL10, TNF, IFNG
26	Malaria20	9.5	IFNG, IL1B, IL10, TNF
27	MSP-RON Signaling36	9.5	TNF, IFNG, IL1B
28	Leishmaniasis20	9.4	IFNG, TNF, IL10, IL1B, NOS2
29	Chagas disease (American trypanosomiasis)20	9.4	IL1B, IFNG, IL10, NOS2, TNF
30	Toxoplasmosis20	9.3	IFNG, IL10, CCR5, NOS2, TNF
31	Tuberculosis20	9.3	NOS2, IFNG, IL1B, IL10, TNF
32	African trypanosomiasis20	9.2	IL1B, IL10, IFNG, F2RL1, TNF
33	Th1 Differentiation37	9.2	TNF, IFNG, CD4, IL10
34	TGF-Beta Pathway36	9.2	CXCL12, IL1B, IL10, CD4, BDNF
35	all-trans-Retinoic Acid Signaling in Brain36	9.1	IL1B, TNF, IL10, CXCL12
36	T cell receptor signaling pathway20	9.1	TNF, IFNG, IL10, CD4
37	MAPK Family Pathway36	9.1	CXCL12, BDNF, TNF, IL1B, CD4, IL10
38	Akt Signaling36	9.0	CXCL12, CCR3, CCR5, IL10, CD4, CXCR4
39	Tec Kinases Signaling36	9.0	IL10, CXCL12, CCR3, CCR5, CD4, BDNF
40	STAT3 Pathway36	8.8	CXCR4, IL10, IL1B, CCR5, CCR3, TNF
41	Antioxidant Action of Vitamin-C36	8.6	CD4, CXCL12, TNF, CCR3, CCR5, IL1B
42	p38 Signaling36	8.6	CXCR4, CXCL12, TNF, BDNF, CD4, IL10
43	JAK-STAT Pathway36	8.6	IL10, CXCL12, CXCR4, IFNG, CD4, BDNF
44	Cytokine-cytokine receptor interaction20	8.5	CCR5, CD27, IL10, IL1B, CCR3, IFNG

Compounds related to aids dementia complex according to GeneDecks:

(show top 50)    (show all 186)

id	Compound	Score	Top Affiliating Genes
1	ivig32	10.4	CCR5, MBP
2	bicyclam32	10.1	ITIH4, CXCR4, CCR5, CXCL12
3	endotoxin32	9.9	PLAUR, F2RL1
4	c-d4i32	9.8	CXCR4, CCR5, ITIH4, CD4
5	pge232	9.8	F2RL1, PLAUR, ITIH4, CD4
6	h2o232	9.6	SLC1A2, BDNF, SLC6A3, ITIH4, MBP
7	opiate32	9.5	CCR5, CCR3, F2RL1, TAT, SLC6A3, ITIH4
8	galactosylceramide32	9.5	CXCR4, CXCL12, CCR5, MBP, ITIH4, CD4
9	ly29400232	9.4	TNF, NOS2, F2RL1, IL10, IL1B
10	groalpha32	9.4	CXCL12, IL10, TNF, CCR5, IL1B
11	taurine chloramine32	9.4	NOS2, TNF, IL1B, IFNG
12	oxygen32 18	10.4	NOS2, SLC1A2, TAT, BDNF, PLAUR, CCR3
13	sb 20358032 42	10.2	TNF, PLAUR, CXCR4, CXCL12, F2RL1, IFNG
14	vesnarinone32	9.1	NOS2, IL1B, TNF, IFNG
15	rolipram32 42	10.1	IL10, CD9, MBP, IFNG, TNF
16	cocaine32 9 9	11.0	BDNF, ITIH4, CD9, S100B, MBP, CCR5
17	aspartate32	9.0	SLC1A2, SLC6A3, CXCR4, TAT, MBP, ITIH4
18	quinine32 9 9	11.0	CXCR4, CCR3, BDNF, S100B, IL10, CCR5
19	chloroquine32 34 9 9	12.0	B2M, TAT, TNF, IL10, ITIH4, CD4
20	vegf32	9.0	TAT, S100B, BDNF, IL1B, F2RL1, CXCL12
21	heparin32 9 18 9	12.0	CD4, ITIH4, MBP, CCR3, F2RL1, TAT
22	nmda32 42	9.9	TAT, CXCL12, CXCR4, SLC1A2, SLC6A3, NOS2
23	pentoxifylline32 9 9	10.9	TAT, TNF, IL1B, IL10, CD9, IFNG
24	butyrate32	8.8	B2M, CCR5, CCR3, IFNG, PLAUR, TAT
25	glutamate32	8.8	CXCR4, SLC1A2, CD4, MBP, CCR5, CXCL12
26	adenylate32	8.7	BDNF, SLC1A2, CXCR4, CXCL12, TAT, NOS2
27	ccl332	8.6	CCR5, IL1B, CCR3, TNF, TAT, IL10
28	zidovudine32 9 9	10.6	B2M, CCR5, IL10, ITIH4, CD9, CD4
29	herbimycin a32 42	9.5	PLAUR, IFNG, CXCR4, CXCL12, CD4, IL1B
30	citrulline32 18	9.5	IL10, SOD1, NOS2, IFNG, MBP
31	tarc32	8.4	CXCR4, CXCL12, TNF, IFNG, CCR3, IL10
32	mdms32	8.4	S100B, CD4, CD9, IL10, CCR5, CXCL12
33	neopterin32	8.4	PLAUR, TNF, IFNG, IL1B, CD4, B2M
34	histamine32 18	9.2	TNF, TAT, IFNG, BDNF, IL10, IL1B
35	lactate32	8.2	BDNF, S100B, B2M, ITIH4, MBP, TNF
36	arginine32	8.1	SLC1A2, SLC6A3, SOD1, TAT, PLAUR, S100B
37	rantes32	8.1	CCR5, CCR3, IFNG, F2RL1, TAT, CXCL12
38	actinomycin d32	8.1	BDNF, IL1B, ITIH4, CCR5, CCR3, IFNG
39	indomethacin32 9 9	10.1	BDNF, SOD1, TAT, NOS2, PLAUR, TNF
40	cyclosporin a32 42	9.0	CCR5, TAT, IFNG, F2RL1, MBP, IL10
41	cysteine32	7.9	ITIH4, CD27, S100B, SLC1A2, CD4, MBP
42	genistein32 9 18 9	10.6	IL1B, B2M, CCR3, IFNG, F2RL1, CD9
43	retinoic acid32 42 18	9.5	IFNG, TAT, MBP, CD9, IL1B, CCR5
44	dexamethasone32 42 34 9 9	11.5	F2RL1, CXCR4, CXCL12, TAT, NOS2, PLAUR
45	thymidine32 18	8.5	S100B, B2M, IL10, CXCL12, BDNF, IL1B
46	serine32	7.2	MBP, F2RL1, CXCR4, CCR5, TNF, SLC6A3
47	cycloheximide32	7.2	B2M, PLAUR, TNF, F2RL1, IFNG, MBP
48	lipid32	6.9	BDNF, SLC1A2, MBP, SOD1, CD9, CCR3
49	nitric oxide32 9 18 9	9.8	SLC1A2, IFNG, TNF, IL1B, IL10, F2RL1
50	alanine32	6.8	SLC6A3, ITIH4, SLC1A2, CD4, S100B, B2M

Cellular components related to aids dementia complex according to GeneDecks:

id	Name	GO ID	Score	Top Affiliating Genes
1	integral to plasma membrane	GO:005887	8.6	SLC6A3, PLAUR, TNF, CCR3, CCR5, CD9
2	external side of plasma membrane	GO:009897	8.0	CXCL12, CXCR4, B2M, CD4, CD27, CD9
3	extracellular space	GO:005615	7.7	IL1B, B2M, IL10, CCR3, IFNG, TNF
4	extracellular region	GO:005576	7.1	IL1B, IFNG, ITIH4, CXCL12, CD27, B2M
5	plasma membrane	GO:005886	6.5	MBP, CCR5, CCR3, GOLPH3, F2RL1, TNF

Biological processes related to aids dementia complex according to GeneDecks:

(show all 30)

id	Name	GO ID	Score	Top Affiliating Genes
1	chronic inflammatory response to antigenic stimulus	GO:002439	10.3	TNF, IL1B
2	sequestering of triglyceride	GO:030730	10.3	IL1B, TNF
3	positive regulation of heterotypic cell-cell adhesion	GO:034116	10.2	IL1B, TNF
4	chemokine-mediated signaling pathway	GO:070098	10.2	CXCL12, CCR3, CCR5
5	regulation of I-kappaB kinase/NF-kappaB cascade	GO:043122	10.1	TNF, IL1B, F2RL1
6	positive regulation of vitamin D biosynthetic process	GO:060557	10.1	IFNG, TNF
7	ameboidal cell migration	GO:001667	10.0	CXCL12, CXCR4
8	receptor biosynthetic process	GO:032800	10.0	IL10, TNF
9	positive regulation of killing of cells of other organism	GO:051712	10.0	IFNG, NOS2
10	positive regulation of calcidiol 1-monooxygenase activity	GO:060559	10.0	IFNG, TNF, IL1B
11	entry into host cell	GO:030260	10.0	CD4, CCR5, CXCR4
12	positive regulation of chemokine biosynthetic process	GO:045080	9.9	TNF, IFNG, IL1B
13	positive regulation of membrane protein ectodomain proteolysis	GO:051044	9.9	IL1B, TNF, IFNG
14	calcium-mediated signaling	GO:019722	9.9	TNF, CCR5, CXCR4
15	negative regulation of cytokine secretion involved in immune response	GO:002740	9.9	IL10, TNF
16	chemotaxis	GO:006935	9.9	CCR3, CXCL12, PLAUR, CCR5
17	positive regulation of nitric oxide biosynthetic process	GO:045429	9.8	IL1B, IFNG, TNF
18	positive regulation of JNK cascade	GO:046330	9.8	CD27, IL1B, F2RL1, TNF
19	response to hypoxia	GO:001666	9.8	IL1B, TNF, NOS2, CXCL12, CXCR4
20	response to glucocorticoid stimulus	GO:051384	9.8	IL1B, TAT, TNF, IL10
21	elevation of cytosolic calcium ion concentration	GO:007204	9.8	IL1B, CCR3, CCR5, F2RL1, CXCR4
22	regulation of insulin secretion	GO:050796	9.7	TNF, IFNG, IL1B, NOS2
23	negative regulation of growth of symbiont in host	GO:044130	9.7	TNF, IFNG, IL10
24	cellular response to lipopolysaccharide	GO:071222	9.5	NOS2, IFNG, CCR5, IL10
25	activation of MAPK activity	GO:000187	9.3	SOD1, TNF, CXCR4, IL1B
26	positive regulation of I-kappaB kinase/NF-kappaB cascade	GO:043123	9.3	S100B, IL1B, F2RL1, TNF
27	inflammatory response	GO:006954	9.1	IL10, CCR5, CCR3, F2RL1, TNF, CXCR4
28	response to heat	GO:009408	8.9	IL1B, CXCL12, SOD1
29	anti-apoptosis	GO:006916	8.7	CD27, BDNF, SOD1, IL10, IL1B, TNF
30	response to drug	GO:042493	8.3	B2M, BDNF, TNF, IL10, SOD1, SLC6A3

Molecular functions related to aids dementia complex according to GeneDecks:

id	Name	GO ID	Score	Top Affiliating Genes
1	coreceptor activity	GO:015026	9.3	CXCR4, CCR5, CD4
2	protein binding	GO:005515	5.6	SLC6A3, SOD1, CXCR4, NOS2, PLAUR, SMCR7L