MCID: ANH001
MIFTS: 28

Ainhum malady

Categories: Rare diseases, Skin diseases

Aliases & Classifications for Ainhum

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Aliases & Descriptions for Ainhum:

Name: Ainhum 10 45 12 36 65
Spontaneous Dactylolysis 45
 
Dactylolysis Spontanea 10

Characteristics:



Classifications:



External Ids:

Disease Ontology10 DOID:11329
ICD1027 L94.6
ICD9CM29 136.0
SNOMED-CT59 38528001, 51404004
MeSH36 D000387
NCIt42 C84544
UMLS65 C0001860

Summaries for Ainhum

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NIH Rare Diseases:45 Ainhum is the autoamputation of a finger or toe as a result of a fibrotic band that constricts the finger or toe until it falls off. ainhum most often affects the fifth toe on both feet. ainhum is believed to be triggered by some sort of trauma, but the exact reason why it happens is not well understood. the condition mainly affects people that live in tropical regions.  last updated: 5/8/2014

MalaCards based summary: Ainhum, also known as spontaneous dactylolysis, is related to cervicitis and hepatitis, and has symptoms including amniotic constriction ring An important gene associated with Ainhum is GJB2 (Gap Junction Protein Beta 2). Affiliated tissues include skin, brain and liver.

Disease Ontology:10 A connective tissue disease that results in increasing fibrous constriction and ultimately in spontaneous amputation of the toes and especially the little toes. A painful constriction of the base of the fifth toe frequently followed by bilateral spontaneous amputation (autoamputation) a few years later.

Wikipedia:68 Ainhum (from Portuguese, pronounced īn-yoom´, i´num or ān´hum; also known as dactylolysis... more...

Related Diseases for Ainhum

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Graphical network of the top 20 diseases related to Ainhum:



Diseases related to ainhum

Symptoms for Ainhum

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HPO human phenotypes related to Ainhum:

id Description Frequency HPO Source Accession
1 amniotic constriction ring HP:0009775

Drugs & Therapeutics for Ainhum

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Interventional clinical trials:


Cochrane evidence based reviews: ainhum

Genetic Tests for Ainhum

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Anatomical Context for Ainhum

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MalaCards organs/tissues related to Ainhum:

33
Skin, Brain, Liver, Bone, Placenta, Myeloid, Uterus

Animal Models for Ainhum or affiliated genes

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Publications for Ainhum

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Articles related to Ainhum:

(show top 50)    (show all 104)
idTitleAuthorsYear
1
Recent Clinical Trials in Osteoporosis: A Firm Foundation or Falling Short? (27191848)
2016
2
Commentary on: Prevalence of Body Dysmorphic Disorder Symptoms and Body Weight Concerns in Patients Seeking Abdominoplasty. (26879298)
2016
3
Brain insulin-like growth factor-I directs the transition from stem cells to mature neurons during postnatal/adult hippocampal neurogenesis. (27144663)
2016
4
Long-term visual prognosis of peripheral multifocal chorioretinitis. (25595670)
2015
5
NELL-1 in the treatment of osteoporotic bone loss. (26082355)
2015
6
Antibiotics for children with acute otitis media--reply. (25898063)
2015
7
Kaposi's Sarcoma-Associated Herpesvirus Viral Interferon Regulatory Factor 1 Interacts with a Member of the Interferon-Stimulated Gene 15 Pathway. (26355087)
2015
8
Donor IL-18 rs5744247 polymorphism as a new biomarker of tacrolimus elimination in Chinese liver transplant patients during the early post-transplantation period: results from two cohort studies. (25712187)
2015
9
Finite element analysis of pectus carinatum surgical correction via a minimally invasive approach. (24428546)
2014
10
Evaluation of retinal nerve fiber layer thickness in migraine. (24250902)
2013
11
A broad survey of cathepsin K immunoreactivity in human neoplasms. (23355199)
2013
12
Renoprotective capacities of non-erythropoietic EPO derivative, ARA290, following renal ischemia/reperfusion injury. (24225194)
2013
13
Unique structural, dynamical, and functional properties of k11-linked polyubiquitin chains. (23823328)
2013
14
Efficacy of lafutidine, a histamine H2-receptor antagonist, for taxane-induced peripheral neuropathy in patients with gynecological malignancies. (22750259)
2012
15
TASK-3 channel deletion in mice recapitulates low-renin essential hypertension. (22493079)
2012
16
ABCA1 gene variants regulate postprandial lipid metabolism in healthy men. (20185793)
2010
17
Cystic duct tubular adenocarcinoma. (19923822)
2009
18
Acute bronchiolitis and croup. (19135584)
2009
19
Genome-wide SNP-based linkage scan identifies a locus on 8q24 for an age-related hearing impairment trait. (18760390)
2008
20
Anti-apoptotic effects of probucol are associated with downregulation of Daxx expression in THP-1 macrophage. (17370120)
2007
21
Non-Hodgkin's lymphoma associated with leiomyomatosis presenting with intense pruritus. (17340029)
2007
22
Angiogenesis and lymphangiogenesis in thyroid proliferative lesions: relationship to type and tumour behaviour. (16954441)
2006
23
A neutralizing anti-fibroblast growth factor 8 monoclonal antibody shows potent antitumor activity against androgen-dependent mouse mammary tumors in vivo. (15897591)
2005
24
MxA and PKR expression in chronic hepatitis C. (15684819)
2004
25
mRNA expression of leukemia-associated antigens in patients with acute myeloid leukemia for the development of specific immunotherapies. (14696097)
2004
26
Surgical trauma and vein graft failure: further evidence for a role of ET-1 in graft occlusion. (15838269)
2004
27
Transgenic mice expressing fibroblast growth factor 23 under the control of the alpha1(I) collagen promoter exhibit growth retardation, osteomalacia, and disturbed phosphate homeostasis. (14988389)
2004
28
Melanotic neuroectodermal tumor of infancy (MNTI). (14696149)
2004
29
Discrepancy between macroscopic and microscopic transitional zones in Hirschsprung's disease with reference to the type of RET/GDNF/SOX10 gene mutation. (12720173)
2003
30
Effects of fatty acids on gene expression: role of peroxisome proliferator-activated receptor alpha, liver X receptor alpha and sterol regulatory element-binding protein-1c. (12230796)
2002
31
Progress in meeting today's demands in genital herpes: an overview of current management. (12353187)
2002
32
Erythropoietin production from CHO cells grown by continuous culture in a fluidized-bed bioreactor. (11753926)
2002
33
Kinins, receptors, kininases and inhibitors--where did they lead us? (11258670)
2001
34
Aromatase p450 expression in a feminizing adrenal adenoma presenting as isosexual precocious puberty. (11158024)
2001
35
ATP binding cassette transporter ABCA1 modulates the secretion of apolipoprotein E from human monocyte-derived macrophages. (11427487)
2001
36
Comparison of d-aspartic acid contents in alpha A-crystallin from normal and age-matched cataractous human lenses. (11097850)
2000
37
Optimization of expression of human sulfite oxidase and its molybdenum domain. (11185564)
2000
38
Differential hormone-dependent phosphorylation of progesterone receptor A and B forms revealed by a phosphoserine site-specific monoclonal antibody. (10628747)
2000
39
A kinetic and conformational study on the interaction of tetrahydropteridines with tyrosine hydroxylase. (11076506)
2000
40
Assessing the function of the Ro ribonucleoprotein complex using Caenorhabditis elegans as a biological tool. (10546898)
1999
41
Aortovenous fistula to the inferior mesenteric vein in a ruptured abdominal aortic aneurysm. (9519006)
1998
42
Pneumoconiosis mortality declining. (9046584)
1997
43
Nuclear immunoreaction of p53 protein in soft tissue sarcomas. A possible prognostic factor. (8174045)
1994
44
A case of crescentic glomerulonephritis associated with anti-myeloperoxidase antibody presenting as alveolar hemorrhage]. (8189651)
1994
45
Tyr-129 is important to the peptide ligand affinity and selectivity of human endothelin type A receptor. (8041764)
1994
46
Familial 5q11.2----q13.3 segmental duplication cosegregating with multiple anomalies, including schizophrenia. (1967903)
1990
47
Carbon dioxide laser vaporization of diaphragmatic metastases for cytoreduction of ovarian epithelial cancer. (2216210)
1990
48
Meconium ileus and fibrocystic disease of the pancreas in Japan. (5218840)
1966
49
Streptomycin in treatment of laryngeal tuberculosis. (18885451)
1948
50
Vitamin B1 therapy in cyclic habitual aphthous stomatitis in women. (20255338)
1947

Variations for Ainhum

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Expression for genes affiliated with Ainhum

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Search GEO for disease gene expression data for Ainhum.

Pathways for genes affiliated with Ainhum

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GO Terms for genes affiliated with Ainhum

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Sources for Ainhum

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2CDC
14ExPASy
15FDA
16FMA
24GTR
25HGMD
26HMDB
27ICD10
28ICD10 via Orphanet
29ICD9CM
30IUPHAR
31KEGG
34MedGen
36MeSH
37MESH via Orphanet
38MGI
41NCI
42NCIt
43NDF-RT
46NINDS
47Novoseek
49OMIM
50OMIM via Orphanet
54PubMed
55QIAGEN
60SNOMED-CT via Orphanet
64Tumor Gene Family of Databases
65UMLS
66UMLS via Orphanet