MCID: ANH001
MIFTS: 28

Ainhum malady

Categories: Rare diseases, Skin diseases

Aliases & Classifications for Ainhum

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Aliases & Descriptions for Ainhum:

Name: Ainhum 11 48 39 13 68
Spontaneous Dactylolysis 48
 
Dactylolysis Spontanea 11

Characteristics:


Classifications:



External Ids:

Disease Ontology11 DOID:11329
ICD1030 L94.6
ICD9CM32 136.0
SNOMED-CT62 38528001, 51404004
MeSH39 D000387
NCIt45 C84544

Summaries for Ainhum

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NIH Rare Diseases:48 Ainhum is the autoamputation of a finger or toe as a result of a fibrotic band that constricts the finger or toe until it falls off. Ainhum most often affects the fifth toe on both feet. Ainhum is believed to be triggered by some sort of trauma, but the exact reason why it happens is not well understood. The condition mainly affects people that live in tropical regions.  Last updated: 5/8/2014

MalaCards based summary: Ainhum, also known as spontaneous dactylolysis, is related to ectodermal dysplasia 2, clouston type and small non-cleaved cell lymphoma, and has symptoms including amniotic constriction ring An important gene associated with Ainhum is SLURP1 (Secreted LY6/PLAUR Domain Containing 1), and among its related pathways is Gap junction trafficking. Affiliated tissues include skin.

Disease Ontology:11 A connective tissue disease that results in increasing fibrous constriction and ultimately in spontaneous amputation of the toes and especially the little toes. A painful constriction of the base of the fifth toe frequently followed by bilateral spontaneous amputation (autoamputation) a few years later.

Wikipedia:71 Ainhum (from Portuguese, pronounced īn-yoom´, i´num or ān´hum; also known as dactylolysis... more...

Related Diseases for Ainhum

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Graphical network of the top 20 diseases related to Ainhum:



Diseases related to ainhum

Symptoms & Phenotypes for Ainhum

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Human phenotypes related to Ainhum:

 64
id Description HPO Frequency HPO Source Accession
1 amniotic constriction ring64 HP:0009775

Drugs & Therapeutics for Ainhum

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Interventional clinical trials:


Cochrane evidence based reviews: ainhum

Genetic Tests for Ainhum

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Anatomical Context for Ainhum

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MalaCards organs/tissues related to Ainhum:

36
Skin

Publications for Ainhum

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Articles related to Ainhum:

(show top 50)    (show all 108)
idTitleAuthorsYear
1
Ainhum or Dactylolysis Spontanea: a Missing Toe. (26926903)
2016
2
Late Onset Progressive Symmetric Erythrokeratoderma with Pseudo Ainhum. (27512197)
2016
3
Ainhum - A Rare Case Report. (27190888)
2016
4
Ainhum: A Spot Diagnosis. (27011582)
2015
5
Ainhum leading to fifth-digit amputation. (25440870)
2015
6
Dactylolysis spontanea (ainhum). (26379327)
2015
7
Familial ainhum: a case report of multiple toe involvement in a father and son, staging of ainhum with insight into different types of constricting bands. (25657437)
2015
8
Reversal of pseudo-ainhum with acitretin in Camisa's syndrome. (25382531)
2014
9
Autoamputation of the fifth digit: ainhum (dactylolysis spontanea). (24849649)
2014
10
Ainhum (dactylolysis spontanea): a case with hands and feet involvement. (23872549)
2013
11
Penile pseudo-ainhum associated with lichen sclerosus et atrophicus. (24195101)
2013
12
Vohwinkel syndrome: treatment of pseudo-ainhum. (20465619)
2010
13
Palmoplantar keratoderma, pseudo-ainhum, and universal atrichia: A new patient and review of the palmoplantar keratoderma-congenital alopecia syndrome. (20635335)
2010
14
Destructive deformation of the digits with auto-amputation: a review of pseudo-ainhum. (17567298)
2007
15
Clouston syndrome associated with severe congenital pseudo-ainhum. (17542906)
2007
16
An unusual cause of ulceration: ainhum (dactylolysis spontanea). (17924881)
2007
17
Undiagnosed purpura: a case of autoerythrocyte sensitization syndrome associated with dermatitis artefacta and pseudo-ainhum. (17050937)
2006
18
Dactylolysis spontanea or ainhum involving the big toe. (16331779)
2005
19
Ainhum (dactylolysis spontanea): a radiological survey of 6000 patients. (12500788)
2002
20
A rare association of epidermal nevus syndrome and ainhum-like digital constrictions. (12220284)
2002
21
Images and diagnoses. Ainhum. (10786458)
2000
22
Pseudo-ainhum in discoid lupus erythematosus. (9609990)
1998
23
Surgical correction of pseudo-ainhum in Vohwinkel syndrome. (7561409)
1995
24
Ainhum in supernumery fingers. (20953032)
1995
25
Ainhum presenting to the accident and emergency department. (8110325)
1993
26
Case report: ainhum (spontaneous dactylolysis) in a 65-year-old American black man. (1539609)
1992
27
Ainhum. (2559515)
1989
28
The surgical pathology of ainhum (dactylolysis spontanea). (2423578)
1986
29
Ainhum in a 12-year-old girl. (3780683)
1986
30
Ainhum (dactylolysis spontanea). Report of a bilateral case and literature review. (3806378)
1986
31
Ainhum--a case report. (4078367)
1985
32
Pseudo-ainhum, angiodysplasia and focal acral hyperkeratosis. (4093943)
1985
33
Ainhum--an unusual presentation involving the second toe in a white male. (6701548)
1984
34
Ainhum. (6852001)
1983
35
Ainhum (dactylosis spontanea): a literature review and case report. (7264168)
1981
36
Ainhum and angiodysplasia. (6115161)
1981
37
Ainhum, trichosporiosis and Z-plasty. (7195834)
1981
38
Ainhum; dactylolysis spontanea. (6949057)
1981
39
Ainhum. (7418704)
1980
40
Ainhum. Report of a case. (886138)
1977
41
Classical ainhum in a Zulu albino. (603897)
1977
42
Ainhum. (1279064)
1976
43
Ainhum: treatment with intralesional steroids. (1279067)
1976
44
Editorial: Ainhum. (49609)
1975
45
Ainhum (dactylolysis spontanea): report of a case. (1056506)
1975
46
Letter: Ainhum. (51987)
1975
47
Letter: Ainhum. (49726)
1975
48
Letter: Ainhum. (50529)
1975
49
An investigation into the prevalence and geographical distribution of Ainhum in the Tsolo district of the Transkei. (4432202)
1974
50
Ainhum: its possible causation by ingestion of plants. (4692052)
1973

Variations for Ainhum

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Expression for genes affiliated with Ainhum

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Search GEO for disease gene expression data for Ainhum.

Pathways for genes affiliated with Ainhum

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Pathways related to Ainhum according to GeneCards Suite gene sharing:

idSuper pathwaysScoreTop Affiliating Genes
1
Show member pathways
9.1GJA1, GJB2

GO Terms for genes affiliated with Ainhum

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Cellular components related to Ainhum according to GeneCards Suite gene sharing:

idNameGO IDScoreTop Affiliating Genes
1connexin complexGO:00059229.6GJA1, GJB2
2gap junctionGO:00059219.6GJA1, GJB2
3lateral plasma membraneGO:00163289.1GJA1, GJB2

Biological processes related to Ainhum according to GeneCards Suite gene sharing:

idNameGO IDScoreTop Affiliating Genes
1gap junction assemblyGO:00162649.8GJA1, GJB2
2negative regulation of cell proliferationGO:00082858.7GJA1, GML, SLURP1

Molecular functions related to Ainhum according to GeneCards Suite gene sharing:

idNameGO IDScoreTop Affiliating Genes
1gap junction channel activityGO:00052439.1GJA1, GJB2

Sources for Ainhum

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2CDC
6CNVD
10DGIdb
15ExPASy
16FDA
17FMA
27GTR
28HGMD
29HMDB
30ICD10
31ICD10 via Orphanet
32ICD9CM
33IUPHAR
34KEGG
37MedGen
39MeSH
40MESH via Orphanet
41MGI
44NCI
45NCIt
46NDF-RT
49NINDS
50Novoseek
52OMIM
53OMIM via Orphanet
57PubMed
58QIAGEN
63SNOMED-CT via Orphanet
67Tumor Gene Family of Databases
68UMLS
69UMLS via Orphanet