MCID: ANH001
MIFTS: 28

Ainhum malady

Rare diseases, Skin diseases categories
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Summaries for Ainhum

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NIH Rare Diseases:42 Ainhum is the autoamputation of a finger or toe as a result of a fibrotic band that constricts the finger or toe until it falls off. ainhum most often affects the fifth toe on both feet. ainhum is believed to be triggered by some sort of trauma, but the exact reason why it happens is not well understood. the condition mainly affects people that live in tropical regions.  last updated: 5/8/2014

MalaCards based summary: Ainhum, also known as spontaneous dactylolysis, is related to vohwinkel syndrome and x-linked ichthyosis, and has symptoms including Affiliated tissues include skin.

Disease Ontology:8 A connective tissue disease that results in increasing fibrous constriction and ultimately in spontaneous amputation of the toes and especially the little toes. a painful constriction of the base of the fifth toe frequently followed by bilateral spontaneous amputation (autoamputation) a few years later.

Wikipedia:65 Ainhum (from Portuguese, pronounced ?n-yoom more...

Description from OMIM:46 103400

Aliases & Classifications for Ainhum

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Ainhum, Aliases & Descriptions:

Name: Ainhum 8 42 62
Spontaneous Dactylolysis 42 62
 
Dactylolysis Spontanea 8 62


Classifications:

Malacards categories (disease lists): (See all malacards categories)
Global: Rare diseases
Anatomical: Skin diseases


External Ids:

Disease Ontology8 DOID:11329
NCIt39 C84544
ICD9CM27 136.0
SNOMED-CT57 51404004, 38528001
OMIM46 103400
MeSH34 D000387
ICD1025 L94.6

Related Diseases for Ainhum

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Diseases related to Ainhum via text searches within MalaCards or GeneCards/GeneDecks gene sharing:

(show top 50)    (show all 118)
idRelated DiseaseScoreTop Affiliating Genes
1vohwinkel syndrome10.1
2x-linked ichthyosis10.0
3angiodysplasia10.0
4syringomyelia10.0
5pityriasis rubra pilaris10.0
6erythrokeratodermia variabilis et progressiva10.0
7keratoderma10.0
8ifap syndrome with or without bresheck syndrome10.0
9alopecia9.9
10diabetes mellitus9.9
11fucosidosis9.9
12sjogren-larsson syndrome9.9
13systemic scleroderma9.9
14rothmund-thomson syndrome9.9
15wolman disease9.9
16lipoid proteinosis9.9
17fabry disease9.9
18leopard syndrome9.9
19clouston syndrome9.9
20polydactyly9.9
21reactive arthritis9.9
22werner syndrome9.9
23epidermolytic hyperkeratosis9.9
24mongolian spot9.9
25hailey-hailey disease9.9
26monilethrix9.9
27costello syndrome9.9
28bart-pumphrey syndrome9.9
29tyrosinemia type ii9.9
30incontinentia pigmenti achromians9.9
31papillon-lefevre disease9.9
32dermatitis9.9
33eosinophilia9.9
34keratosis9.9
35lupus erythematosus9.9
36purpura9.9
37oculocutaneous albinism type 19.9
38acrokeratoelastoidosis of costa9.9
39acute febrile neutrophilic dermatosis9.9
40ameloonychohypohidrotic syndrome9.9
41arthrogryposis and ectodermal dysplasia9.9
42children's interstitial lung disease9.9
43cobb syndrome9.9
44craniosynostosis, anal anomalies, and porokeratosis9.9
45degos 'en cocarde' erythrokeratoderma9.9
46dermatoleukodystrophy9.9
47ectodermal dysplasia blindness9.9
48ectodermal dysplasia skin fragility syndrome9.9
49epidermolysis bullosa simplex, dowling-meara type9.9
50epidermolysis bullosa simplex, generalized9.9

Graphical network of the top 20 diseases related to Ainhum:



Diseases related to ainhum

Symptoms for Ainhum

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Clinical features from OMIM:

103400

HPO human phenotypes related to Ainhum:

id Description Frequency HPO Source Accession
1 autosomal dominant inheritance HP:0000006
2 amniotic constriction ring HP:0009775

Drugs & Therapeutics for Ainhum

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Drug clinical trials:

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Genetic Tests for Ainhum

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Anatomical Context for Ainhum

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MalaCards organs/tissues related to Ainhum:

32
Skin

Animal Models for Ainhum or affiliated genes

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Publications for Ainhum

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Articles related to Ainhum:

(show top 50)    (show all 101)
idTitleAuthorsYear
1
Reversal of pseudo-ainhum with acitretin in Camisa's syndrome. (25382531)
2014
2
Ainhum (dactylolysis spontanea): a case with hands and feet involvement. (23872549)
2013
3
Penile pseudo-ainhum associated with lichen sclerosus et atrophicus. (24195101)
2013
4
Palmoplantar keratoderma, pseudo-ainhum, and universal atrichia: A new patient and review of the palmoplantar keratoderma-congenital alopecia syndrome. (20635335)
2010
5
Destructive deformation of the digits with auto-amputation: a review of pseudo-ainhum. (17567298)
2007
6
Clouston syndrome associated with severe congenital pseudo-ainhum. (17542906)
2007
7
Dactylolysis spontanea or ainhum involving the big toe. (16331779)
2005
8
Ainhum (dactylolysis spontanea): a radiological survey of 6000 patients. (12500788)
2002
9
Pseudo-ainhum in discoid lupus erythematosus. (9609990)
1998
10
Ainhum in supernumery fingers. (20953032)
1995
11
Case report: ainhum (spontaneous dactylolysis) in a 65-year-old American black man. (1539609)
1992
12
Ainhum. (2559515)
1989
13
The surgical pathology of ainhum (dactylolysis spontanea). (2423578)
1986
14
Ainhum in a 12-year-old girl. (3780683)
1986
15
Ainhum (dactylolysis spontanea). Report of a bilateral case and literature review. (3806378)
1986
16
Ainhum--a case report. (4078367)
1985
17
Ainhum (dactylosis spontanea): a literature review and case report. (7264168)
1981
18
Ainhum, trichosporiosis and Z-plasty. (7195834)
1981
19
Ainhum. (7418704)
1980
20
Ainhum. (1279064)
1976
21
Ainhum: treatment with intralesional steroids. (1279067)
1976
22
Letter: Ainhum. (51987)
1975
23
Letter: Ainhum. (49726)
1975
24
Ainhum (dactylolysis spontanea): a review of the literature and a report of two cases. (4927166)
1971
25
Ainhum (dactylolysis spontanea). (5241101)
1968
26
Hereditary keratodermia and ainhum. (6064941)
1967
27
The clinico-roentgenologic features of ainhum. (6028958)
1967
28
Ainhum with keratoderma palmaris et plantaris with keratosis pilaris in an Indian female. (5954187)
1966
29
A case of congenital pseudo ainhum. (5882081)
1965
30
AINHUM: AN ACCOUNT OF FIFTY-FOUR PATIENTS WITH SPECIAL REFERENCE TO ETIOLOGY AND TREATMENT. (14296245)
1965
31
AINHUM (DACTYLOLYSIS SPONTANEA). (14342009)
1965
32
Ainhum. Report of an atypical case. (14040961)
1963
33
Dactylolysis spontanea (ainhum). Report of a case treated by the surgical procedure known as Z-plasty. (14012203)
1963
34
AINHUM AND PSEUDOAINHUM. REPORT OF THREE CASES. (14042848)
1963
35
Ainhum. A clinical and etiological study of 83 cases. (13873764)
1961
36
Ainhum. (13766019)
1961
37
Ainhum-dactylolysis spontanea-a case report. (13751291)
1960
38
A plethysmographic study of the toe of a patient with ainhum. (13434515)
1957
39
Ainhum. (15412193)
1950
40
Ainhum (dactylolysis spontanea); a review of 10 cases. (15433202)
1950
41
Ainhum or dactylolysis spontanea; report of a case. (18903108)
1948
42
Constriction of the finger simulating ainhum; report of a congenital case. (18886283)
1948
43
Ainhum; report of a case in which the patient was a white woman with diabetes mellitus. (20288664)
1947
44
Ainhum. (20995060)
1946
45
Ainhum. (20289413)
1946
46
Ainhum. (21000223)
1946
47
Pityriasis Rubra Pilaris with Ainhum and Syringomyelia. (19993248)
1946
48
Ainhum. (21001310)
1946
49
Ainhum; report of a case. (20994158)
1946
50
Ainhum or "Ring-Toe". (20891321)
1913

Variations for Ainhum

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Expression for genes affiliated with Ainhum

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Pathways for genes affiliated with Ainhum

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Compounds for genes affiliated with Ainhum

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GO Terms for genes affiliated with Ainhum

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Sources for Ainhum

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3CDC
13ExPASy
14FMA
22GTR
23HGMD
24HMDB
25ICD10
26ICD10 via Orphanet
27ICD9CM
28IUPHAR
29KEGG
34MeSH
35MESH via Orphanet
36MGI
39NCIt
40NDF-RT
43NINDS
44Novoseek
46OMIM
47OMIM via Orphanet
51PubMed
52QIAGEN
58SNOMED-CT via Orphanet
62UMLS
63UMLS via Orphanet