MCID: ANH001
MIFTS: 27

Ainhum malady

Categories: Rare diseases, Skin diseases

Aliases & Classifications for Ainhum

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Aliases & Descriptions for Ainhum:

Name: Ainhum 10 45 12 36 65
Spontaneous Dactylolysis 45
 
Dactylolysis Spontanea 10

Characteristics:



Classifications:



External Ids:

Disease Ontology10 DOID:11329
ICD1027 L94.6
ICD9CM29 136.0
SNOMED-CT59 38528001, 51404004
MeSH36 D000387
NCIt42 C84544
UMLS65 C0001860

Summaries for Ainhum

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NIH Rare Diseases:45 Ainhum is the autoamputation of a finger or toe as a result of a fibrotic band that constricts the finger or toe until it falls off. ainhum most often affects the fifth toe on both feet. ainhum is believed to be triggered by some sort of trauma, but the exact reason why it happens is not well understood. the condition mainly affects people that live in tropical regions.  last updated: 5/8/2014

MalaCards based summary: Ainhum, also known as spontaneous dactylolysis, is related to pityriasis rubra pilaris and vohwinkel syndrome, and has symptoms including amniotic constriction ring An important gene associated with Ainhum is GJB2 (Gap Junction Protein Beta 2). Affiliated tissues include b cells, brain and skin.

Disease Ontology:10 A connective tissue disease that results in increasing fibrous constriction and ultimately in spontaneous amputation of the toes and especially the little toes. A painful constriction of the base of the fifth toe frequently followed by bilateral spontaneous amputation (autoamputation) a few years later.

Wikipedia:68 Ainhum (from Portuguese, pronounced īn-yoom´, i´num or ān´hum; also known as dactylolysis... more...

Related Diseases for Ainhum

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Diseases related to Ainhum via text searches within MalaCards or GeneCards Suite gene sharing:

(show all 15)
idRelated DiseaseScoreTop Affiliating Genes
1pityriasis rubra pilaris9.9
2vohwinkel syndrome9.9
3angiodysplasia9.9
4syringomyelia9.9
5alopecia9.8
6polydactyly9.8
7keratosis9.8
8dermatitis9.8
9purpura9.8
10lupus erythematosus9.8
11eosinophilia9.8
12lichen sclerosus9.8
13pseudoainhum9.8
14focal acral hyperkeratosis9.8
15discoid lupus erythematosus9.8

Graphical network of diseases related to Ainhum:



Diseases related to ainhum

Symptoms for Ainhum

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HPO human phenotypes related to Ainhum:

id Description Frequency HPO Source Accession
1 amniotic constriction ring HP:0009775

Drugs & Therapeutics for Ainhum

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Interventional clinical trials:


Cochrane evidence based reviews: ainhum

Genetic Tests for Ainhum

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Anatomical Context for Ainhum

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MalaCards organs/tissues related to Ainhum:

33
B cells, Brain, Skin, Prostate, Endothelial, Liver, Myeloid

Animal Models for Ainhum or affiliated genes

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Publications for Ainhum

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Articles related to Ainhum:

(show top 50)    (show all 107)
idTitleAuthorsYear
1
Dactylolysis spontanea (ainhum). (26379327)
2015
2
Familial ainhum: a case report of multiple toe involvement in a father and son, staging of ainhum with insight into different types of constricting bands. (25657437)
2015
3
Ainhum: A Spot Diagnosis. (27011582)
2015
4
Ainhum leading to fifth-digit amputation. (25440870)
2015
5
Reversal of pseudo-ainhum with acitretin in Camisa's syndrome. (25382531)
2014
6
Ainhum (dactylolysis spontanea): a case with hands and feet involvement. (23872549)
2013
7
Penile pseudo-ainhum associated with lichen sclerosus et atrophicus. (24195101)
2013
8
Palmoplantar keratoderma, pseudo-ainhum, and universal atrichia: A new patient and review of the palmoplantar keratoderma-congenital alopecia syndrome. (20635335)
2010
9
Destructive deformation of the digits with auto-amputation: a review of pseudo-ainhum. (17567298)
2007
10
Clouston syndrome associated with severe congenital pseudo-ainhum. (17542906)
2007
11
Dactylolysis spontanea or ainhum involving the big toe. (16331779)
2005
12
Ainhum (dactylolysis spontanea): a radiological survey of 6000 patients. (12500788)
2002
13
Pseudo-ainhum in discoid lupus erythematosus. (9609990)
1998
14
Ainhum in supernumery fingers. (20953032)
1995
15
Case report: ainhum (spontaneous dactylolysis) in a 65-year-old American black man. (1539609)
1992
16
The surgical pathology of ainhum (dactylolysis spontanea). (2423578)
1986
17
Ainhum in a 12-year-old girl. (3780683)
1986
18
Ainhum (dactylolysis spontanea). Report of a bilateral case and literature review. (3806378)
1986
19
Ainhum--a case report. (4078367)
1985
20
Ainhum (dactylosis spontanea): a literature review and case report. (7264168)
1981
21
Ainhum, trichosporiosis and Z-plasty. (7195834)
1981
22
Ainhum. (7418704)
1980
23
Ainhum. (1279064)
1976
24
Ainhum: treatment with intralesional steroids. (1279067)
1976
25
Letter: Ainhum. (51987)
1975
26
Ainhum (dactylolysis spontanea): a review of the literature and a report of two cases. (4927166)
1971
27
Ainhum (dactylolysis spontanea). (5241101)
1968
28
Hereditary keratodermia and ainhum. (6064941)
1967
29
The clinico-roentgenologic features of ainhum. (6028958)
1967
30
Ainhum with keratoderma palmaris et plantaris with keratosis pilaris in an Indian female. (5954187)
1966
31
A case of congenital pseudo ainhum. (5882081)
1965
32
AINHUM: AN ACCOUNT OF FIFTY-FOUR PATIENTS WITH SPECIAL REFERENCE TO ETIOLOGY AND TREATMENT. (14296245)
1965
33
AINHUM (DACTYLOLYSIS SPONTANEA). (14342009)
1965
34
Ainhum. Report of an atypical case. (14040961)
1963
35
Dactylolysis spontanea (ainhum). Report of a case treated by the surgical procedure known as Z-plasty. (14012203)
1963
36
AINHUM AND PSEUDOAINHUM. REPORT OF THREE CASES. (14042848)
1963
37
Ainhum. A clinical and etiological study of 83 cases. (13873764)
1961
38
Ainhum. (13766019)
1961
39
Ainhum-dactylolysis spontanea-a case report. (13751291)
1960
40
A plethysmographic study of the toe of a patient with ainhum. (13434515)
1957
41
Ainhum. (15412193)
1950
42
Ainhum or dactylolysis spontanea; report of a case. (18903108)
1948
43
Constriction of the finger simulating ainhum; report of a congenital case. (18886283)
1948
44
Ainhum; report of a case in which the patient was a white woman with diabetes mellitus. (20288664)
1947
45
Ainhum. (20995060)
1946
46
Ainhum. (20289413)
1946
47
Ainhum. (21000223)
1946
48
Pityriasis Rubra Pilaris with Ainhum and Syringomyelia. (19993248)
1946
49
Ainhum. (21001310)
1946
50
Ainhum or "Ring-Toe". (20891321)
1913

Variations for Ainhum

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Expression for genes affiliated with Ainhum

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Search GEO for disease gene expression data for Ainhum.

Pathways for genes affiliated with Ainhum

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GO Terms for genes affiliated with Ainhum

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Sources for Ainhum

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2CDC
14ExPASy
15FDA
16FMA
24GTR
25HGMD
26HMDB
27ICD10
28ICD10 via Orphanet
29ICD9CM
30IUPHAR
31KEGG
34MedGen
36MeSH
37MESH via Orphanet
38MGI
41NCI
42NCIt
43NDF-RT
46NINDS
47Novoseek
49OMIM
50OMIM via Orphanet
54PubMed
55QIAGEN
60SNOMED-CT via Orphanet
64Tumor Gene Family of Databases
65UMLS
66UMLS via Orphanet