MCID: ANH001
MIFTS: 30

Ainhum malady

Rare diseases, Skin diseases categories

Aliases & Classifications for Ainhum

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Aliases & Descriptions for Ainhum:

Name: Ainhum 10 45 12 65 36
Spontaneous Dactylolysis 45
 
Dactylolysis Spontanea 10


Classifications:



External Ids:

Disease Ontology10 DOID:11329
NCIt42 C84544
ICD9CM29 136.0
SNOMED-CT59 51404004, 38528001
MeSH36 D000387
ICD1027 L94.6

Summaries for Ainhum

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NIH Rare Diseases:45 Ainhum is the autoamputation of a finger or toe as a result of a fibrotic band that constricts the finger or toe until it falls off. ainhum most often affects the fifth toe on both feet. ainhum is believed to be triggered by some sort of trauma, but the exact reason why it happens is not well understood. the condition mainly affects people that live in tropical regions.  last updated: 5/8/2014

MalaCards based summary: Ainhum, also known as spontaneous dactylolysis, is related to vohwinkel syndrome and pityriasis rubra pilaris, and has symptoms including autosomal dominant inheritanceand amniotic constriction ring. An important gene associated with Ainhum is TRPV3 (Transient Receptor Potential Cation Channel, Subfamily V, Member 3). Affiliated tissues include skin, and related mouse phenotype integument.

Disease Ontology:10 A connective tissue disease that results in increasing fibrous constriction and ultimately in spontaneous amputation of the toes and especially the little toes. a painful constriction of the base of the fifth toe frequently followed by bilateral spontaneous amputation (autoamputation) a few years later.

Wikipedia:68 Ainhum (from Portuguese, pronounced īn-yoom´, i´num or ān´hum; also known as dactylolysis... more...

Related Diseases for Ainhum

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Diseases related to Ainhum via text searches within MalaCards or GeneCards Suite gene sharing:

(show top 50)    (show all 114)
idRelated DiseaseScoreTop Affiliating Genes
1vohwinkel syndrome10.2
2pityriasis rubra pilaris10.1
3angiodysplasia10.1
4syringomyelia10.1
5erythrokeratodermia variabilis et progressiva9.9
6fucosidosis9.9
7ectodermal dysplasia 10b, hypohidrotic/hair/tooth type, autosomal recessive9.9
8ichthyosis, autosomal recessive 4b9.9
9sialidosis, type i9.9
10cardiofaciocutaneous syndrome9.9
11keratolytic winter erythema9.9
12werner syndrome9.9
13epidermolysis bullosa simplex, ogna type9.9
14wolman disease9.9
15costello syndrome9.9
16albinism, oculocutaneous, type ia9.9
17papillon-lefevre syndrome9.9
18ehlers-danlos syndrome, type viii9.9
19epidermolytic hyperkeratosis9.9
20ichthyosis histrix, curth-macklin type9.9
21epidermolysis bullosa simplex, dowling-meara type9.9
22monilethrix9.9
23keratoderma, palmoplantar, with deafness9.9
24proteus syndrome, somatic9.9
25tyrosinemia, type ii9.9
26sjogren-larsson syndrome9.9
27prolidase deficiency9.9
28kindler syndrome9.9
29schindler disease, type i9.9
30kanzaki disease9.9
31cdags syndrome9.9
32ichthyosis, x-linked9.9
33fabry disease9.9
34incontinentia pigmenti9.9
35urbach-wiethe disease9.9
36hailey-hailey disease9.9
37meleda disease9.9
38epidermolysis bullosa simplex, koebner type9.9
39darier disease9.9
40olmsted syndrome9.9
41chime syndrome9.9
42child syndrome9.9
43alopecia9.9
44systemic scleroderma9.9
45leopard syndrome9.9
46porokeratosis9.9
47hermansky-pudlak syndrome9.9
48polydactyly9.9
49dyskeratosis congenita9.9
50congenital ichthyosiform erythroderma9.9

Graphical network of the top 20 diseases related to Ainhum:



Diseases related to ainhum

Symptoms for Ainhum

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HPO human phenotypes related to Ainhum:

id Description Frequency HPO Source Accession
1 autosomal dominant inheritance HP:0000006
2 amniotic constriction ring HP:0009775

Drugs & Therapeutics for Ainhum

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Interventional clinical trials:


Cochrane evidence based reviews: Ainhum

Genetic Tests for Ainhum

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Anatomical Context for Ainhum

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MalaCards organs/tissues related to Ainhum:

33
Skin

Animal Models for Ainhum or affiliated genes

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MGI Mouse Phenotypes related to Ainhum:

38
idDescriptionMGI Source AccessionScoreTop Affiliating Genes
1MP:00107719.1GJB2, TRPV3

Publications for Ainhum

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Articles related to Ainhum:

(show top 50)    (show all 104)
idTitleAuthorsYear
1
Dactylolysis spontanea (ainhum). (26379327)
2015
2
Familial ainhum: a case report of multiple toe involvement in a father and son, staging of ainhum with insight into different types of constricting bands. (25657437)
2015
3
Ainhum leading to fifth-digit amputation. (25440870)
2015
4
Reversal of pseudo-ainhum with acitretin in Camisa's syndrome. (25382531)
2014
5
Ainhum (dactylolysis spontanea): a case with hands and feet involvement. (23872549)
2013
6
Penile pseudo-ainhum associated with lichen sclerosus et atrophicus. (24195101)
2013
7
Palmoplantar keratoderma, pseudo-ainhum, and universal atrichia: A new patient and review of the palmoplantar keratoderma-congenital alopecia syndrome. (20635335)
2010
8
Destructive deformation of the digits with auto-amputation: a review of pseudo-ainhum. (17567298)
2007
9
Clouston syndrome associated with severe congenital pseudo-ainhum. (17542906)
2007
10
Dactylolysis spontanea or ainhum involving the big toe. (16331779)
2005
11
Ainhum (dactylolysis spontanea): a radiological survey of 6000 patients. (12500788)
2002
12
Pseudo-ainhum in discoid lupus erythematosus. (9609990)
1998
13
Ainhum in supernumery fingers. (20953032)
1995
14
Case report: ainhum (spontaneous dactylolysis) in a 65-year-old American black man. (1539609)
1992
15
The surgical pathology of ainhum (dactylolysis spontanea). (2423578)
1986
16
Ainhum in a 12-year-old girl. (3780683)
1986
17
Ainhum (dactylolysis spontanea). Report of a bilateral case and literature review. (3806378)
1986
18
Ainhum--a case report. (4078367)
1985
19
Ainhum (dactylosis spontanea): a literature review and case report. (7264168)
1981
20
Ainhum, trichosporiosis and Z-plasty. (7195834)
1981
21
Ainhum. (7418704)
1980
22
Ainhum. (1279064)
1976
23
Ainhum: treatment with intralesional steroids. (1279067)
1976
24
Letter: Ainhum. (51987)
1975
25
Ainhum (dactylolysis spontanea): a review of the literature and a report of two cases. (4927166)
1971
26
Ainhum (dactylolysis spontanea). (5241101)
1968
27
Hereditary keratodermia and ainhum. (6064941)
1967
28
The clinico-roentgenologic features of ainhum. (6028958)
1967
29
Ainhum with keratoderma palmaris et plantaris with keratosis pilaris in an Indian female. (5954187)
1966
30
A case of congenital pseudo ainhum. (5882081)
1965
31
AINHUM: AN ACCOUNT OF FIFTY-FOUR PATIENTS WITH SPECIAL REFERENCE TO ETIOLOGY AND TREATMENT. (14296245)
1965
32
AINHUM (DACTYLOLYSIS SPONTANEA). (14342009)
1965
33
Ainhum. Report of an atypical case. (14040961)
1963
34
Dactylolysis spontanea (ainhum). Report of a case treated by the surgical procedure known as Z-plasty. (14012203)
1963
35
AINHUM AND PSEUDOAINHUM. REPORT OF THREE CASES. (14042848)
1963
36
Ainhum. A clinical and etiological study of 83 cases. (13873764)
1961
37
Ainhum. (13766019)
1961
38
Ainhum-dactylolysis spontanea-a case report. (13751291)
1960
39
A plethysmographic study of the toe of a patient with ainhum. (13434515)
1957
40
Ainhum. (15412193)
1950
41
Ainhum or dactylolysis spontanea; report of a case. (18903108)
1948
42
Constriction of the finger simulating ainhum; report of a congenital case. (18886283)
1948
43
Ainhum; report of a case in which the patient was a white woman with diabetes mellitus. (20288664)
1947
44
Ainhum. (20995060)
1946
45
Ainhum. (20289413)
1946
46
Ainhum. (21000223)
1946
47
Pityriasis Rubra Pilaris with Ainhum and Syringomyelia. (19993248)
1946
48
Ainhum. (21001310)
1946
49
Ainhum; report of a case. (20994158)
1946
50
Ainhum or "Ring-Toe". (20891321)
1913

Variations for Ainhum

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Expression for genes affiliated with Ainhum

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Search GEO for disease gene expression data for Ainhum.

Pathways for genes affiliated with Ainhum

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GO Terms for genes affiliated with Ainhum

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Biological processes related to Ainhum according to GeneCards Suite gene sharing:

idNameGO IDScoreTop Affiliating Genes
1transmembrane transportGO:00550859.1GJB2, TRPV3

Sources for Ainhum

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2CDC
14ExPASy
15FDA
16FMA
24GTR
25HGMD
26HMDB
27ICD10
28ICD10 via Orphanet
29ICD9CM
30IUPHAR
31KEGG
34MedGen
36MeSH
37MESH via Orphanet
38MGI
41NCI
42NCIt
43NDF-RT
46NINDS
47Novoseek
49OMIM
50OMIM via Orphanet
54PubMed
55QIAGEN
60SNOMED-CT via Orphanet
64Tumor Gene Family of Databases
65UMLS
66UMLS via Orphanet