MCID: ANH001
MIFTS: 28

Ainhum malady

Categories: Rare diseases, Skin diseases

Aliases & Classifications for Ainhum

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Aliases & Descriptions for Ainhum:

Name: Ainhum 11 47 38 13 67
Spontaneous Dactylolysis 47
 
Dactylolysis Spontanea 11

Characteristics:


Classifications:



External Ids:

Disease Ontology11 DOID:11329
ICD1029 L94.6
ICD9CM31 136.0
SNOMED-CT61 38528001, 51404004
MeSH38 D000387
NCIt44 C84544

Summaries for Ainhum

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Disease Ontology:11 A connective tissue disease that results in increasing fibrous constriction and ultimately in spontaneous amputation of the toes and especially the little toes. A painful constriction of the base of the fifth toe frequently followed by bilateral spontaneous amputation (autoamputation) a few years later.

MalaCards based summary: Ainhum, also known as spontaneous dactylolysis, is related to ectodermal dysplasia 2, clouston type and small non-cleaved cell lymphoma, and has symptoms including amniotic constriction ring An important gene associated with Ainhum is SLURP1 (Secreted LY6/PLAUR Domain Containing 1), and among its related pathways is Gap junction trafficking. Affiliated tissues include skin.

Wikipedia:70 Ainhum (from Portuguese, pronounced īn-yoom´, i´num or ān´hum; also known as dactylolysis... more...

Related Diseases for Ainhum

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Graphical network of the top 20 diseases related to Ainhum:



Diseases related to ainhum

Symptoms for Ainhum

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Human phenotypes related to Ainhum:

 63
id Description HPO Frequency HPO Source Accession
1 amniotic constriction ring63 HP:0009775

Drugs & Therapeutics for Ainhum

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Interventional clinical trials:


Cochrane evidence based reviews: ainhum

Genetic Tests for Ainhum

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Anatomical Context for Ainhum

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MalaCards organs/tissues related to Ainhum:

35
Skin

Animal Models for Ainhum or affiliated genes

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Publications for Ainhum

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Articles related to Ainhum:

(show top 50)    (show all 108)
idTitleAuthorsYear
1
Ainhum or Dactylolysis Spontanea: a Missing Toe. (26926903)
2016
2
Ainhum: A Spot Diagnosis. (27011582)
2015
3
Ainhum leading to fifth-digit amputation. (25440870)
2015
4
Vohwinkel syndrome: treatment of pseudo-ainhum. (20465619)
2010
5
Destructive deformation of the digits with auto-amputation: a review of pseudo-ainhum. (17567298)
2007
6
Clouston syndrome associated with severe congenital pseudo-ainhum. (17542906)
2007
7
An unusual cause of ulceration: ainhum (dactylolysis spontanea). (17924881)
2007
8
Undiagnosed purpura: a case of autoerythrocyte sensitization syndrome associated with dermatitis artefacta and pseudo-ainhum. (17050937)
2006
9
Ainhum (dactylolysis spontanea): a radiological survey of 6000 patients. (12500788)
2002
10
A rare association of epidermal nevus syndrome and ainhum-like digital constrictions. (12220284)
2002
11
Surgical correction of pseudo-ainhum in Vohwinkel syndrome. (7561409)
1995
12
Ainhum presenting to the accident and emergency department. (8110325)
1993
13
Case report: ainhum (spontaneous dactylolysis) in a 65-year-old American black man. (1539609)
1992
14
Ainhum. (2559515)
1989
15
Ainhum--a case report. (4078367)
1985
16
Pseudo-ainhum, angiodysplasia and focal acral hyperkeratosis. (4093943)
1985
17
Ainhum (dactylosis spontanea): a literature review and case report. (7264168)
1981
18
Ainhum and angiodysplasia. (6115161)
1981
19
Ainhum. (7418704)
1980
20
Ainhum. Report of a case. (886138)
1977
21
Editorial: Ainhum. (49609)
1975
22
Ainhum (dactylolysis spontanea): report of a case. (1056506)
1975
23
An investigation into the prevalence and geographical distribution of Ainhum in the Tsolo district of the Transkei. (4432202)
1974
24
Ainhum: its possible causation by ingestion of plants. (4692052)
1973
25
Polydactyly with ainhum in all the extra digits, hyperkeratosis palmaris et plantaris, and idiopathic eosinophilia. A new association. (5764299)
1969
26
Ainhum in a female child involving a great toe. (6030802)
1967
27
AINHUM: AN ACCOUNT OF FIFTY-FOUR PATIENTS WITH SPECIAL REFERENCE TO ETIOLOGY AND TREATMENT. (14296245)
1965
28
Ainhum. Report of an atypical case. (14040961)
1963
29
AINHUM AND PSEUDOAINHUM. REPORT OF THREE CASES. (14042848)
1963
30
Ainhum. A clinical and etiological study of 83 cases. (13873764)
1961
31
Ainhum. (13766019)
1961
32
Ainhum-dactylolysis spontanea-a case report. (13751291)
1960
33
Bilateral ainhum treated by multiple Z-plasties. (13657730)
1959
34
Ainhum of the fingers: a case from Sierra Leone. (13625376)
1958
35
A plethysmographic study of the toe of a patient with ainhum. (13434515)
1957
36
Ainhum (dactylosis spontanea); report of a case. (13457622)
1957
37
Ainhum. (13463040)
1957
38
Ainhum. (13274672)
1956
39
Ainhum (dactylolysis spontanea); report of a case. (14799465)
1951
40
Ainhum; report of a case with bilateral involvement. (14776842)
1950
41
Constriction of the finger simulating ainhum; report of a congenital case. (18886283)
1948
42
Ainhum in a leper. (20270463)
1947-1948
43
Ainhum. (21000223)
1946
44
Pityriasis Rubra Pilaris with Ainhum and Syringomyelia. (19993248)
1946
45
Ainhum. (21001310)
1946
46
Ainhum; report of a case. (20994158)
1946
47
AINHUM. (17865998)
1928
48
XIV. Ainhum: With Report of a Case. (17862188)
1908
49
Ainhum on the West Coast of Africa. (20753349)
1891
50
Case of Ainhum. (20753257)
1891

Variations for Ainhum

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Expression for genes affiliated with Ainhum

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Search GEO for disease gene expression data for Ainhum.

Pathways for genes affiliated with Ainhum

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Pathways related to Ainhum according to GeneCards Suite gene sharing:

idSuper pathwaysScoreTop Affiliating Genes
1
Show member pathways
9.1GJA1, GJB2

GO Terms for genes affiliated with Ainhum

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Cellular components related to Ainhum according to GeneCards Suite gene sharing:

idNameGO IDScoreTop Affiliating Genes
1connexin complexGO:00059229.6GJA1, GJB2
2lateral plasma membraneGO:00163289.1GJA1, GJB2
3gap junctionGO:00059218.8GJA1, GJB2

Biological processes related to Ainhum according to GeneCards Suite gene sharing:

idNameGO IDScoreTop Affiliating Genes
1gap junction assemblyGO:00162649.5GJA1, GJB2
2negative regulation of cell proliferationGO:00082858.7GJA1, GML, SLURP1

Molecular functions related to Ainhum according to GeneCards Suite gene sharing:

idNameGO IDScoreTop Affiliating Genes
1gap junction channel activityGO:00052439.1GJA1, GJB2

Sources for Ainhum

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2CDC
6CNVD
10DGIdb
15ExPASy
16FDA
17FMA
26GTR
27HGMD
28HMDB
29ICD10
30ICD10 via Orphanet
31ICD9CM
32IUPHAR
33KEGG
36MedGen
38MeSH
39MESH via Orphanet
40MGI
43NCI
44NCIt
45NDF-RT
48NINDS
49Novoseek
51OMIM
52OMIM via Orphanet
56PubMed
57QIAGEN
62SNOMED-CT via Orphanet
66Tumor Gene Family of Databases
67UMLS
68UMLS via Orphanet