MCID: AKN002
MIFTS: 33

Akinetic Mutism

Categories: Neuronal diseases

Aliases & Classifications for Akinetic Mutism

MalaCards integrated aliases for Akinetic Mutism:

Name: Akinetic Mutism 12 51 41 14 69
Coma Vigilans 12

Classifications:



External Ids:

Disease Ontology 12 DOID:4267
MeSH 41 D000405
SNOMED-CT 64 5124002 53333005
UMLS 69 C0001889

Summaries for Akinetic Mutism

Disease Ontology : 12 A brain disease characterized by marked reduction of nearly all motor functions including facial expressions, gestures and speech output, but with some degree of alertness.

MalaCards based summary : Akinetic Mutism, also known as coma vigilans, is related to brain injury and aphasia. An important gene associated with Akinetic Mutism is SLC6A3 (Solute Carrier Family 6 Member 3), and among its related pathways/superpathways are Neuroscience and Copper homeostasis. Affiliated tissues include brain, eye and thyroid, and related phenotypes are behavior/neurological and nervous system

Wikipedia : 72 Akinetic mutism is a medical term describing patients tending neither to move (akinesia) nor speak... more...

Related Diseases for Akinetic Mutism

Diseases related to Akinetic Mutism via text searches within MalaCards or GeneCards Suite gene sharing:

(show all 49)
# Related Disease Score Top Affiliating Genes
1 brain injury 30.3 ENO2 MAPT
2 aphasia 29.9 MAPT PRNP
3 hydrocephalus 29.9 ENO2 MAPT
4 creutzfeldt-jakob disease 29.7 ENO2 MAPT PRNP
5 mutism 11.0
6 cerebritis 10.5
7 cerebral artery occlusion 10.2
8 obstructive hydrocephalus 10.2
9 anterior cerebral artery infarction 10.2
10 traumatic brain injury 10.1
11 leukoencephalopathy, hereditary diffuse, with spheroids 10.1 MAPT PRNP
12 toxic encephalopathy 10.1 PRNP SLC6A3
13 agraphia 10.1 MAPT PRNP
14 cerebral amyloid angiopathy, cst3-related 10.1 MAPT PRNP
15 multiple system atrophy 1 10.0 MAPT SLC6A3
16 scrapie 10.0 ENO2 PRNP
17 supranuclear palsy, progressive, 1 10.0 MAPT SLC6A3
18 movement disease 9.9 MAPT SLC6A3
19 vascular dementia 9.9 MAPT PRNP
20 multiple sclerosis 9.9
21 schizophrenia 9.9
22 lung cancer 9.9
23 papilloma of choroid plexus 9.9
24 wilson disease 9.9
25 obesity, hyperphagia, and developmental delay 9.9
26 immunodeficiency, common variable, 10 9.9
27 choroiditis 9.9
28 locked-in syndrome 9.9
29 dementia 9.9
30 basilar artery occlusion 9.9
31 cervicitis 9.9
32 papilloma 9.9
33 astrocytoma 9.9
34 craniopharyngioma 9.9
35 hemangioblastoma 9.9
36 progressive multifocal leukoencephalopathy 9.9
37 thyroiditis 9.9
38 intestinal obstruction 9.9
39 glioma 9.9
40 streptococcal group a invasive disease 9.9
41 aneurysm 9.9
42 anoxia 9.9
43 serotonin syndrome 9.9
44 synucleinopathy 9.9 MAPT SLC6A3
45 disease of mental health 9.8 MAPT SLC6A3
46 dementia, lewy body 9.8 MAPT PRNP SLC6A3
47 nervous system disease 9.8 MAPT PRNP SLC6A3
48 central nervous system disease 9.8 MAPT PRNP SLC6A3
49 prion disease 9.7 ENO2 MAPT PRNP

Graphical network of the top 20 diseases related to Akinetic Mutism:



Diseases related to Akinetic Mutism

Symptoms & Phenotypes for Akinetic Mutism

MGI Mouse Phenotypes related to Akinetic Mutism:

43
# Description MGI Source Accession Score Top Affiliating Genes
1 behavior/neurological MP:0005386 9.55 CTSF ENO2 MAPT PRNP SLC6A3
2 nervous system MP:0003631 9.35 CTSF ENO2 MAPT PRNP SLC6A3
3 taste/olfaction MP:0005394 8.8 ENO2 MAPT SLC6A3

Drugs & Therapeutics for Akinetic Mutism

Interventional clinical trials:


# Name Status NCT ID Phase Drugs
1 Vagal Nerve Stimulation in Coma Patients Recruiting NCT02591069

Search NIH Clinical Center for Akinetic Mutism

Cochrane evidence based reviews: akinetic mutism

Genetic Tests for Akinetic Mutism

Anatomical Context for Akinetic Mutism

MalaCards organs/tissues related to Akinetic Mutism:

38
Brain, Eye, Thyroid, Lung, Bone Marrow, Bone, Liver

Publications for Akinetic Mutism

Articles related to Akinetic Mutism:

(show top 50) (show all 111)
# Title Authors Year
1
Akinetic mutism following prefrontal injury by an electrical grinder a case report: A diffusion tensor tractography study. ( 29419694 )
2018
2
Akinetic mutism reversibility after L-dopa therapy in unilateral left anterior cerebral artery infarction. ( 28447507 )
2017
3
Serotonin Syndrome Following Combined Administration of Dopaminergic and Noradrenergic Agents in a Patient With Akinetic Mutism After Frontal Intracerebral Hemorrhage: A Case Report. ( 28622210 )
2017
4
Recovery of akinetic mutism and injured prefronto-caudate tract following shunt operation for hydrocephalus and rehabilitation: A case report. ( 29390310 )
2017
5
Akinetic mutism in a patient with acute infarcts in the bilateral substantia nigra. ( 28131224 )
2017
6
The Electroencephalogram Speaks for the Patient: Identification and Treatment of Akinetic Mutism With Comorbid Delirium. ( 29249557 )
2017
7
Akinetic mutism and the story of David. ( 28150524 )
2017
8
Akinetic mutism in a patient with mild traumatic brain injury: A diffusion tensor tractography study. ( 28406325 )
2017
9
Reversible Changes of Brain Perfusion SPECT for Carbon Monoxide Poisoning-Induced Severe Akinetic Mutism. ( 26825206 )
2016
10
Akinetic mutism revealing an ischemic stroke. ( 27955795 )
2016
11
Reversible Akinetic Mutism after Aneurysmal Subarachnoid Haemorrhage in the Territory of the Anterior Cerebral Artery without Permanent Ischaemic Damage to Anterior Cingulate Gyri. ( 27418987 )
2016
12
Unique presentation of akinetic mutism and coexisting thyroid storm relating to stroke. ( 25530892 )
2014
13
Akinetic mutism and utilization behavior after bilateral thalamo-polar artery stroke. ( 23775322 )
2013
14
Delayed post-hypoxic leucoencephalopathy presenting akinetic mutism after traumatic cervical cord injury: a case report. ( 23472625 )
2013
15
Telephone effect in akinetic mutism from traumatic brain injury. ( 23932533 )
2013
16
Akinetic mutism-a serious complication to tacrolimus-based GVHD prophylaxis. ( 22705799 )
2013
17
Akinetic mutism without a structural prefrontal lesion. ( 23812168 )
2013
18
Akinetic Mutism and Parkinsonism due to Subdural and Intraventricular Tension Pneumocephalus. ( 23322598 )
2013
19
Akinetic mutism caused by HIV-associated progressive multifocal leukoencephalopathy was successfully treated with mefloquine: a serial multimodal MRI Study. ( 22246492 )
2012
20
Akinetic mutism and parkinsonism after multiple shunt failure: case report and literature review. ( 21445822 )
2012
21
Rapid resolution of akinetic mutism in delayed post-hypoxic leukoencephalopathy with intravenous magnesium sulfate. ( 22672948 )
2012
22
Vegetative state, minimally conscious state, akinetic mutism and Parkinsonism as a continuum of recovery from disorders of consciousness: an exploratory and preliminary study. ( 21693084 )
2011
23
Survival to akinetic mutism state in Japanese cases of MM1-type sporadic Creutzfeldt-Jakob disease is similar to Caucasians. ( 20722706 )
2011
24
Leukoencephalopathy and akinetic mutism in a married couple: a probable association with oriental medicine. ( 22259619 )
2011
25
Treatment of chronic akinetic mutism with atomoxetine: subtraction analysis of brain f-18 fluorodeoxyglucose positron emission tomographic images before and after medication: a case report. ( 20661027 )
2010
26
Akinetic mutism induced by tacrolimus. ( 19820432 )
2009
27
Akinetic mutism--not coma. ( 19297375 )
2009
28
Persistent akinetic mutism after bilateral paramedian thalamic infarction. ( 19776325 )
2009
29
Treatment of akinetic mutism with intramuscular olanzapine: a case series. ( 18305290 )
2008
30
Diminution of basal ganglia dopaminergic function may play an important role in the generation of akinetic mutism in a patient with anterior cerebral arterial infarct. ( 17543443 )
2007
31
Akinetic mutism after right internal watershed infarction. ( 17453106 )
2007
32
Akinetic mutism caused by nicotine withdrawal. ( 19455735 )
2007
33
Akinetic mutism responsive to bromocriptine following subdural hematoma evacuation in a patient with hydrocephalus. ( 17895616 )
2007
34
Akinetic Mutism and Cognitive-Affective Syndrome Caused by Unilateral PICA Infarction. ( 19513131 )
2007
35
Akinetic mutism followed by a manic reaction on introduction of steroid replacement for Addison's disease. ( 16682841 )
2006
36
Frontal lobe and cingulate cortical metabolic dysfunction in acquired akinetic mutism: a PET study of the interval form of carbon monoxide poisoning. ( 15204341 )
2004
37
Preserved auditory cognitive ERPs in severe akinetic mutism: a case report. ( 15019716 )
2004
38
Subarachnoid haemorrhage and akinetic mutism. ( 15327227 )
2004
39
Akinetic mutism following stroke. ( 14642361 )
2004
40
Event-related brain potentials in a patient with akinetic mutism. ( 12711129 )
2003
41
Akinetic mutism following unilateral anterior cerebral artery occlusion. ( 12928521 )
2003
42
OKT3 neurotoxicity presenting as akinetic mutism. ( 12698102 )
2003
43
Bromocriptine-responsive akinetic mutism following endoscopy for ventricular neurocysticercosis. Case report and review of the literature. ( 12924716 )
2003
44
Clinicopathologic case report: akinetic mutism with findings of white matter hyperintensity. ( 11983799 )
2002
45
Akinetic mutism caused by bilateral infiltration of the fornix in a patient with astrocytoma. ( 11985642 )
2002
46
Chronic akinetic mutism after mesencephalic-diencephalic infarction: remediated with dopaminergic medications. ( 11811256 )
2001
47
BIPLEDs in akinetic mutism caused by bilateral anterior cerebral artery infarction. ( 11514256 )
2001
48
Akinetic mutism from frontal lobe damage responding to levodopa. ( 10993505 )
2000
49
Reversible akinetic mutism possibly induced by baclofen. ( 10212020 )
1999
50
Akinetic mutism and mixed transcortical aphasia following left thalamo-mesencephalic infarction. ( 10223414 )
1999

Variations for Akinetic Mutism

Expression for Akinetic Mutism

Search GEO for disease gene expression data for Akinetic Mutism.

Pathways for Akinetic Mutism

Pathways related to Akinetic Mutism according to GeneCards Suite gene sharing:

# Super pathways Score Top Affiliating Genes
1 11.33 ENO2 MAPT PRNP
2 10.69 MAPT PRNP

GO Terms for Akinetic Mutism

Cellular components related to Akinetic Mutism according to GeneCards Suite gene sharing:

# Name GO ID Score Top Affiliating Genes
1 neuronal cell body GO:0043025 8.8 ENO2 MAPT SLC6A3

Biological processes related to Akinetic Mutism according to GeneCards Suite gene sharing:

# Name GO ID Score Top Affiliating Genes
1 positive regulation of neuron death GO:1901216 8.62 MAPT PRNP

Molecular functions related to Akinetic Mutism according to GeneCards Suite gene sharing:

# Name GO ID Score Top Affiliating Genes
1 protease binding GO:0002020 9.16 PRNP SLC6A3
2 tubulin binding GO:0015631 8.96 MAPT PRNP
3 protein phosphatase 2A binding GO:0051721 8.62 MAPT SLC6A3

Sources for Akinetic Mutism

3 CDC
7 CNVD
9 Cosmic
10 dbSNP
11 DGIdb
16 ExPASy
18 FMA
27 GO
28 GTR
29 HGMD
30 HMDB
31 HPO
32 ICD10
33 ICD10 via Orphanet
34 ICD9CM
35 IUPHAR
36 KEGG
37 LifeMap
39 MedGen
41 MeSH
42 MESH via Orphanet
43 MGI
45 NCI
46 NCIt
47 NDF-RT
50 NINDS
51 Novoseek
53 OMIM
54 OMIM via Orphanet
58 PubMed
60 QIAGEN
65 SNOMED-CT via HPO
66 SNOMED-CT via Orphanet
67 TGDB
68 Tocris
69 UMLS
70 UMLS via Orphanet
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