MCID: AKN002
MIFTS: 30

Akinetic Mutism

Categories: Neuronal diseases

Aliases & Classifications for Akinetic Mutism

MalaCards integrated aliases for Akinetic Mutism:

Name: Akinetic Mutism 12 52 42 14 69
Coma Vigilans 12

Classifications:



External Ids:

Disease Ontology 12 DOID:4267
MeSH 42 D000405
SNOMED-CT 64 5124002 53333005
UMLS 69 C0001889

Summaries for Akinetic Mutism

Disease Ontology : 12 A brain disease characterized by marked reduction of nearly all motor functions including facial expressions, gestures and speech output, but with some degree of alertness.

MalaCards based summary : Akinetic Mutism, also known as coma vigilans, is related to mutism and cerebritis. An important gene associated with Akinetic Mutism is SLC6A3 (Solute Carrier Family 6 Member 3), and among its related pathways/superpathways are Neuroscience and Copper homeostasis. Affiliated tissues include brain, eye and thyroid, and related phenotypes are behavior/neurological and nervous system

Wikipedia : 72 Akinetic mutism is a medical term describing patients tending neither to move (akinesia) nor speak... more...

Related Diseases for Akinetic Mutism

Diseases related to Akinetic Mutism via text searches within MalaCards or GeneCards Suite gene sharing:

(show all 50)
id Related Disease Score Top Affiliating Genes
1 mutism 10.8
2 cerebritis 10.4
3 hydrocephalus 10.2
4 hyperekplexia, hereditary 1, autosomal dominant or recessive 10.1 MAPT PRNP
5 supranuclear palsy, progressive atypical 10.1 MAPT SLC6A3
6 ovarian cystadenocarcinoma 10.1 PRNP SLC6A3
7 3mc syndrome 10.1 MAPT PRNP
8 cerebral artery occlusion 10.1
9 obstructive hydrocephalus 10.1
10 nosophobia 10.1 MAPT PRNP
11 brain injury 10.1
12 anterior cerebral artery infarction 10.1
13 papillary hidradenoma 10.1 ENO2 PRNP
14 submandibular adenitis 10.1 ENO2 MAPT
15 ganglioneuroma 10.0 MAPT SLC6A3
16 parietal foramina 3 10.0 MAPT SLC6A3
17 creutzfeldt-jakob disease 10.0
18 traumatic brain injury 10.0
19 adrenal gland pheochromocytoma 9.9 MAPT SLC6A3
20 eumycotic mycetoma 9.9 MAPT PRNP
21 schizophrenia 9.8
22 lung cancer 9.8
23 wilson disease 9.8
24 choroid plexus papilloma 9.8
25 aphasia 9.8
26 choroiditis 9.8
27 locked-in syndrome 9.8
28 dementia 9.8
29 basilar artery occlusion 9.8
30 addison's disease 9.8
31 cervicitis 9.8
32 papilloma 9.8
33 astrocytoma 9.8
34 craniopharyngioma 9.8
35 hemangioblastoma 9.8
36 progressive multifocal leukoencephalopathy 9.8
37 thyroiditis 9.8
38 intestinal obstruction 9.8
39 glioma 9.8
40 aneurysm 9.8
41 anoxia 9.8
42 serotonin syndrome 9.8
43 personality disorder 9.8 MAPT SLC6A3
44 parkinson disease 1 9.8 MAPT PRNP SLC6A3
45 prostate carcinoma in situ 9.8 MAPT PRNP SLC6A3
46 hepatic angiomyolipoma 9.7 MAPT PRNP SLC6A3
47 pediatric myxoid chondrosarcoma 9.7 ENO2 MAPT PRNP
48 prion disease with protracted course 9.7 ENO2 MAPT PRNP
49 ichthyosis lamellar 1 9.5 ENO2 MAPT
50 penis basal cell carcinoma 7.8 CTSF ENO2 MAMLD1 MAPT PRNP SLC6A3

Graphical network of the top 20 diseases related to Akinetic Mutism:



Diseases related to Akinetic Mutism

Symptoms & Phenotypes for Akinetic Mutism

MGI Mouse Phenotypes related to Akinetic Mutism:

44
id Description MGI Source Accession Score Top Affiliating Genes
1 behavior/neurological MP:0005386 9.55 CTSF ENO2 MAPT PRNP SLC6A3
2 nervous system MP:0003631 9.35 CTSF ENO2 MAPT PRNP SLC6A3
3 taste/olfaction MP:0005394 8.8 ENO2 MAPT SLC6A3

Drugs & Therapeutics for Akinetic Mutism

Interventional clinical trials:


id Name Status NCT ID Phase Drugs
1 Vagal Nerve Stimulation in Coma Patients Recruiting NCT02591069

Search NIH Clinical Center for Akinetic Mutism

Cochrane evidence based reviews: akinetic mutism

Genetic Tests for Akinetic Mutism

Anatomical Context for Akinetic Mutism

MalaCards organs/tissues related to Akinetic Mutism:

39
Brain, Eye, Thyroid, Lung, Bone Marrow, Bone, Liver

Publications for Akinetic Mutism

Articles related to Akinetic Mutism:

(show top 50) (show all 108)
id Title Authors Year
1
Akinetic mutism in a patient with mild traumatic brain injury: A diffusion tensor tractography study. ( 28406325 )
2017
2
Serotonin Syndrome Following Combined Administration of Dopaminergic and Noradrenergic Agents in a Patient With Akinetic Mutism After Frontal Intracerebral Hemorrhage: A Case Report. ( 28622210 )
2017
3
Akinetic mutism in a patient with acute infarcts in the bilateral substantia nigra. ( 28131224 )
2017
4
Akinetic mutism reversibility after L-dopa therapy in unilateral left anterior cerebral artery infarction. ( 28447507 )
2017
5
Akinetic mutism and the story of David. ( 28150524 )
2017
6
Reversible Changes of Brain Perfusion SPECT for Carbon Monoxide Poisoning-Induced Severe Akinetic Mutism. ( 26825206 )
2016
7
Reversible Akinetic Mutism after Aneurysmal Subarachnoid Haemorrhage in the Territory of the Anterior Cerebral Artery without Permanent Ischaemic Damage to Anterior Cingulate Gyri. ( 27418987 )
2016
8
Akinetic mutism revealing an ischemic stroke. ( 27955795 )
2016
9
Unique presentation of akinetic mutism and coexisting thyroid storm relating to stroke. ( 25530892 )
2014
10
Delayed post-hypoxic leucoencephalopathy presenting akinetic mutism after traumatic cervical cord injury: a case report. ( 23472625 )
2013
11
Telephone effect in akinetic mutism from traumatic brain injury. ( 23932533 )
2013
12
Akinetic Mutism and Parkinsonism due to Subdural and Intraventricular Tension Pneumocephalus. ( 23322598 )
2013
13
Akinetic mutism and utilization behavior after bilateral thalamo-polar artery stroke. ( 23775322 )
2013
14
Akinetic mutism-a serious complication to tacrolimus-based GVHD prophylaxis. ( 22705799 )
2013
15
Akinetic mutism without a structural prefrontal lesion. ( 23812168 )
2013
16
Akinetic mutism caused by HIV-associated progressive multifocal leukoencephalopathy was successfully treated with mefloquine: a serial multimodal MRI Study. ( 22246492 )
2012
17
Rapid resolution of akinetic mutism in delayed post-hypoxic leukoencephalopathy with intravenous magnesium sulfate. ( 22672948 )
2012
18
Akinetic mutism and parkinsonism after multiple shunt failure: case report and literature review. ( 21445822 )
2012
19
Leukoencephalopathy and akinetic mutism in a married couple: a probable association with oriental medicine. ( 22259619 )
2011
20
Survival to akinetic mutism state in Japanese cases of MM1-type sporadic Creutzfeldt-Jakob disease is similar to Caucasians. ( 20722706 )
2011
21
Vegetative state, minimally conscious state, akinetic mutism and Parkinsonism as a continuum of recovery from disorders of consciousness: an exploratory and preliminary study. ( 21693084 )
2011
22
Treatment of chronic akinetic mutism with atomoxetine: subtraction analysis of brain f-18 fluorodeoxyglucose positron emission tomographic images before and after medication: a case report. ( 20661027 )
2010
23
Akinetic mutism--not coma. ( 19297375 )
2009
24
Akinetic mutism induced by tacrolimus. ( 19820432 )
2009
25
Persistent akinetic mutism after bilateral paramedian thalamic infarction. ( 19776325 )
2009
26
Treatment of akinetic mutism with intramuscular olanzapine: a case series. ( 18305290 )
2008
27
Akinetic mutism after right internal watershed infarction. ( 17453106 )
2007
28
Akinetic Mutism and Cognitive-Affective Syndrome Caused by Unilateral PICA Infarction. ( 19513131 )
2007
29
Akinetic mutism responsive to bromocriptine following subdural hematoma evacuation in a patient with hydrocephalus. ( 17895616 )
2007
30
Diminution of basal ganglia dopaminergic function may play an important role in the generation of akinetic mutism in a patient with anterior cerebral arterial infarct. ( 17543443 )
2007
31
Akinetic mutism caused by nicotine withdrawal. ( 19455735 )
2007
32
Akinetic mutism followed by a manic reaction on introduction of steroid replacement for Addison's disease. ( 16682841 )
2006
33
Preserved auditory cognitive ERPs in severe akinetic mutism: a case report. ( 15019716 )
2004
34
Subarachnoid haemorrhage and akinetic mutism. ( 15327227 )
2004
35
Akinetic mutism following stroke. ( 14642361 )
2004
36
Frontal lobe and cingulate cortical metabolic dysfunction in acquired akinetic mutism: a PET study of the interval form of carbon monoxide poisoning. ( 15204341 )
2004
37
Akinetic mutism following unilateral anterior cerebral artery occlusion. ( 12928521 )
2003
38
OKT3 neurotoxicity presenting as akinetic mutism. ( 12698102 )
2003
39
Bromocriptine-responsive akinetic mutism following endoscopy for ventricular neurocysticercosis. Case report and review of the literature. ( 12924716 )
2003
40
Event-related brain potentials in a patient with akinetic mutism. ( 12711129 )
2003
41
Akinetic mutism caused by bilateral infiltration of the fornix in a patient with astrocytoma. ( 11985642 )
2002
42
Clinicopathologic case report: akinetic mutism with findings of white matter hyperintensity. ( 11983799 )
2002
43
Chronic akinetic mutism after mesencephalic-diencephalic infarction: remediated with dopaminergic medications. ( 11811256 )
2001
44
BIPLEDs in akinetic mutism caused by bilateral anterior cerebral artery infarction. ( 11514256 )
2001
45
Akinetic mutism from frontal lobe damage responding to levodopa. ( 10993505 )
2000
46
Akinetic mutism after fourth ventricle choroid plexus papilloma: treatment with a dopamine agonist. ( 10029425 )
1999
47
Akinetic mutism and mixed transcortical aphasia following left thalamo-mesencephalic infarction. ( 10223414 )
1999
48
Reversible akinetic mutism possibly induced by baclofen. ( 10212020 )
1999
49
A case of unpaired anterior cerebral artery occlusion producing akinetic mutism. ( 10402361 )
1999
50
Episodically remitting akinetic mutism following subarachnoid hemorrhage. ( 9990564 )
1999

Variations for Akinetic Mutism

Expression for Akinetic Mutism

Search GEO for disease gene expression data for Akinetic Mutism.

Pathways for Akinetic Mutism

Pathways related to Akinetic Mutism according to GeneCards Suite gene sharing:

id Super pathways Score Top Affiliating Genes
1 11.31 ENO2 MAPT PRNP
2 10.69 MAPT PRNP

GO Terms for Akinetic Mutism

Biological processes related to Akinetic Mutism according to GeneCards Suite gene sharing:

id Name GO ID Score Top Affiliating Genes
1 positive regulation of neuron death GO:1901216 8.62 MAPT PRNP

Molecular functions related to Akinetic Mutism according to GeneCards Suite gene sharing:

id Name GO ID Score Top Affiliating Genes
1 tubulin binding GO:0015631 8.96 MAPT PRNP
2 protease binding GO:0002020 8.85 SLC6A3
3 protein phosphatase 2A binding GO:0051721 8.62 MAPT SLC6A3

Sources for Akinetic Mutism

3 CDC
7 CNVD
9 Cosmic
10 dbSNP
11 DGIdb
16 ExPASy
18 FMA
28 GO
29 GTR
30 HGMD
31 HMDB
32 HPO
33 ICD10
34 ICD10 via Orphanet
35 ICD9CM
36 IUPHAR
37 KEGG
38 LifeMap
40 MedGen
42 MeSH
43 MESH via Orphanet
44 MGI
46 NCI
47 NCIt
48 NDF-RT
51 NINDS
52 Novoseek
54 OMIM
55 OMIM via Orphanet
59 PubMed
60 QIAGEN
65 SNOMED-CT via HPO
66 SNOMED-CT via Orphanet
67 TGDB
68 Tocris
69 UMLS
70 UMLS via Orphanet
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