MCID: ALC004
MIFTS: 57

Alcohol Abuse malady

Summaries for Alcohol Abuse

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8Disease Ontology, 63Wikipedia, 32MalaCards
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Wikipedia:63 Alcohol abuse, as described in the DSM-IV, is a psychiatric diagnosis describing the recurring use of... more...

MalaCards: Alcohol Abuse, also known as ethanol abuse, is related to alcohol dependence and alcoholic hepatitis. An important gene associated with Alcohol Abuse is ABCB7 (ATP-binding cassette, sub-family B (MDR/TAP), member 7), and among its related pathways are Cytochrome P450 - arranged by substrate type and ethanol degradation II. The compounds vitamin a and 5-hydroxytryptophol have been mentioned in the context of this disorder. Affiliated tissues include liver, brain and testes, and related mouse phenotypes are cardiovascular system and growth/size.

Disease Ontology:8 A substance abuse that involves the recurring use of alcoholic beverages despite negative consequences.

Aliases & Classifications for Alcohol Abuse

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8Disease Ontology, 44Novoseek, 60UMLS, 27ICD9CM, 34MeSH, 56SNOMED-CT, 39NCIt
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Aliases & Descriptions:

alcohol abuse 8 44 60
ethanol abuse 8


External Ids:

Disease Ontology8 DOID:1574
ICD9CM27 305.0, 305.00
SNOMED-CT56 304606004, 15167005
MeSH34 D000437
NCIt39 C20701

Related Diseases for Alcohol Abuse

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Sources:
17GeneCards, 18GeneDecks
See all sources

Diseases in the Alcohol Abuse family:

Alcohol Sensitivity, Acute

Diseases related to Alcohol Abuse via text searches within MalaCards or GeneCards/GeneDecks gene sharing:

(show top 50)    (show all 203)
idRelated DiseaseScoreTop Affiliating Genes
1alcohol dependence31.5ALDH2, GGT1, SLC6A4, TF, DRD2
2alcoholic hepatitis30.8GGT1, SLC17A5, GPT, RPS27A
3hepatitis30.8SLC17A5, GPT
4substance abuse30.8ALDH2, GGT1, SLC6A4, CYP2E1, TF, DRD3
5cocaine abuse30.6SLC6A4, DRD2
6viral hepatitis30.6GGT1, SLC17A5, ABCB7, GPT, HFE, AKR1A1
7schizophrenia30.6DRD3, COMT
8hepatocellular carcinoma30.6ALDH9A1, ALDH2, GGT1, SLC17A5, ABCB7, GPT
9alcoholic pancreatitis30.5ADH1C, ALDH9A1, ALDH2, CYP2E1, AKR1A1
10pancreatitis30.5ADH1C, ALDH9A1, ALDH2, GGT1, SLC17A5, CYP2E1
11bipolar disorder30.5SLC6A4, CREB1, DRD3, DRD2, COMT
12personality disorder30.4SLC6A4, DRD3, DRD2
13hepatitis c30.4GGT1, SLC17A5, ABCB7, GPT, CYP2E1, HFE
14alcoholic liver cirrhosis30.3ADH1C, ALDH9A1, ALDH2, GGT1, SLC17A5, GPT
15liver cirrhosis30.3ADH1C, ALDH2, GGT1, SLC17A5, ABCB7, GPT
16anxiety disorder30.2SLC6A4
17pathological gambling30.2DRD3, DRD2
18drug dependence30.2SLC6A4, DRD3, DRD2
19cocaine dependence30.2SLC6A4, DRD3, DRD2
20conduct disorder30.2SLC6A4, DRD2, COMT
21eating disorder30.2SLC6A4, GAL, COMT
22psychotic disorder30.2SLC6A4, DRD3, DRD2, COMT
23sickle cell disease30.0TF
24infertility30.0RPS27A
25essential hypertension30.0LCAT, COMT
26antisocial personality disorder30.0SLC6A4, DRD2
27tuberculosis30.0CYP2E1, AKR1A1, CREB1
28hypertension30.0GGT1, SLC6A4, COG2
29panic disorder30.0SLC6A4, COMT
30anorexia nervosa30.0SLC6A4, GAL, COMT
31delusional disorder30.0DRD2
32hepatitis b30.0GGT1, SLC17A5, ABCB7, GPT
33deficiency anemia30.0ABCB7, HFE, TF, LCAT
34acute pancreatitis30.0ADH1C, ALDH2, SLC17A5, ABCB7, GPT
35dementia30.0ALDH2, GAL, RPS27A, COMT
36psoriasis30.0SLC6A4, CREB1
37substance dependence30.0SLC6A4, DRD3, DRD2, COMT
38mood disorder30.0SLC6A4, CREB1, GAL, DRD3, DRD2, COMT
39brain disease30.0SLC17A5, ABCB7, GPT
40lung cancer30.0ADH1C, ALDH9A1, ALDH2, CYP2E1, AKR1A1, CREB1
41breast cancer30.0ADH1C, ALDH9A1, ALDH2, CYP2E1, AKR1A1, GAL
42obesity30.0ALDH2, GGT1, SLC17A5, ABCB7, GPT, CYP2E1
43liver disease10.5
44hepatitis a10.4
45wernicke-korsakoff syndrome10.4
46mental depression10.2
47pneumonia10.2
48alcoholic psychosis10.2
49opioid abuse10.2
50neuronitis10.2

Graphical network of the top 20 diseases related to Alcohol Abuse:



Diseases related to alcohol abuse

Clinical Features for Alcohol Abuse

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Drugs & Therapeutics for Alcohol Abuse

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Sources:
5CenterWatch, 41NIH Clinical Center, 6ClinicalTrials, 60UMLS, 40NDF-RT
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Approved drugs:

Search CenterWatch for Alcohol Abuse

Drug clinical trials:

Search ClinicalTrials for Alcohol Abuse

Search NIH Clinical Center for Alcohol Abuse

Search CenterWatch for Alcohol Abuse

Genetic Tests for Alcohol Abuse

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Anatomical Context for Alcohol Abuse

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32MalaCards
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MalaCards organs/tissues related to Alcohol Abuse:

32
Liver, Brain, Testes, Lung, Heart, Bone, Cortex, Amygdala, Endothelial, Breast, Thymus, Whole blood, Prefrontal cortex

Animal Models for Alcohol Abuse or affiliated genes

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36MGI
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MGI Mouse Phenotypes related to Alcohol Abuse:

36
idDescriptionMGI Source AccessionScoreTop Affiliating Genes
1MP:000538510.1ABCB7, CYP2E1, CREB1, DRD3, DRD2, LCAT
2MP:00053789.8CREB1, ABCB7, SLC6A4, SLC17A5, GGT1, ALDH2
3MP:00107689.7CYP2E1, HFE, AKR1A1, CREB1, TF, DRD3
4MP:00053769.7COMT, ADH1C, ALDH2, GGT1, SLC17A5, SLC6A4
5MP:00053869.6HFE, ALDH2, SLC17A5, DRD2, CREB1, GAL

Publications for Alcohol Abuse

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50PubMed
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Articles related to Alcohol Abuse:

(show top 50)    (show all 652)
idTitleAuthorsYear
1
Meta-Analysis of Interventions for Reducing Number of Sexual Partners and Drug and Alcohol Abuse among People Living with HIV/AIDS. (24224118)
2013
2
Giant cell myocarditis and endomyocardial calcification in a 2.5-month-old infant triggered by excessive maternal alcohol abuse: case study of an unusual association. (23341052)
2013
3
Teaching the biological consequences of alcohol abuse through an online game: impacts among secondary students. (22383621)
2012
4
Managed alcohol as a harm reduction intervention for alcohol addiction in populations at high risk for substance abuse. (23235633)
2012
5
The role of biogenic amine signaling in the bed nucleus of the stria terminals in alcohol abuse. (22449787)
2012
6
The effect of alcohol abuse and alcohol withdrawal on short-term outcomes and cost of care after head and neck cancer surgery. (22566069)
2012
7
Adolescent-onset alcohol abuse exacerbates the influence of childhood conduct disorder on late adolescent and early adult antisocial behaviour. (23459369)
2011
8
Past year treatment status and alcohol abuse symptoms among US adults with alcohol dependence. (21315517)
2011
9
Psychoanalytic treatment of psychological addiction to alcohol (alcohol abuse). (22144975)
2011
10
Benzodiazepine prescription among patients with severe mental illness and co-occurring alcohol abuse/dependence in Taiwan. (21671270)
2011
11
A review of technology-assisted self-help and minimal contact therapies for drug and alcohol abuse and smoking addiction: is human contact necessary for therapeutic efficacy? (21095051)
2011
12
Person-environment interaction in the prediction of alcohol abuse and alcohol dependence in adulthood. (20299164)
2010
13
Sexual risk behaviors, alcohol abuse, and intimate partner violence among sex workers in Mongolia: implications for HIV prevention intervention development. (20391057)
2010
14
Correlates of and relationship among lifetime alcohol abuse and alcohol dependence in older community residents in Brazil. (20191090)
2009
15
Dimensionality of lifetime alcohol abuse, dependence and binge drinking. (19095379)
2009
16
Benign symmetric lipomatosis associated with atopic dermatitis and chronic alcohol abuse in a Japanese man. (19688172)
2009
17
Suggestive linkage at 9p22 in bipolar disorder weighted by alcohol abuse. (19259988)
2009
18
Retrospective safety analysis of atomoxetine in adult ADHD patients with or without comorbid alcohol abuse and dependence. (19874159)
2009
19
Conceptualizing impulsivity and risk taking in bipolar disorder: importance of history of alcohol abuse. (19133964)
2009
20
Alcohol abuse and dependence before and after bariatric surgery: a review of the literature and report of a new data set. (18420465)
2008
21
Preventing alcohol abuse and suicidal behaviour among college students. (18642407)
2008
22
Social Welfare Policy and Public Assistance for Low-Income Substance Abusers: The Impact of 1996 Welfare Reform Legislation on the Economic Security of Former Supplemental Security Income Drug Addiction and Alcoholism Beneficiaries. (20396645)
2008
23
triADD: the risk for alcohol abuse, depression, and diabetes multimorbidity in the American Indian and Alaska Native populations. (17602410)
2007
24
Treatment rates for alcohol abuse and dependence remain low. (18217252)
2007
25
Alcohol abuse in mothers during gravidity and breastfeeding brings changes of hippocampal neurons in their offspring. (16752809)
2006
26
Neuropsychological functioning in posttraumatic stress disorder and alcohol abuse. (17100516)
2006
27
Alcohol abuse screening in primary care. (15702019)
2005
28
Should nurses be randomly tested for alcohol abuse? (16116365)
2005
29
Biochemical indicators and cardiac function tests in chronic alcohol abusers. (15849844)
2005
30
Co-occurring DSM-IV drug abuse in DSM-IV drug dependence: results from the National Epidemiologic Survey on Alcohol and Related Conditions. (16157234)
2005
31
Theories of therapeutic evolution for juvenile drug courts in the face of the onset of the co-occurrence of mental health issues and substance/alcohol abuse. (16889116)
2004-2005
32
Depression, alcohol abuse, and generational differences in Mazahua women in a rural Mexican village. (15371136)
2004
33
The co-occurrence of DSM-IV alcohol abuse in DSM-IV alcohol dependence: results of the National Epidemiologic Survey on Alcohol and Related Conditions on heterogeneity that differ by population subgroup. (15351767)
2004
34
Endocrine response to surgical stress and postoperative confusion in depressed patients with alcohol abuse. (15365214)
2004
35
Alcohol abuse and dependence. A clinical update on alcoholism in the older population. (15461237)
2004
36
A modified version of the CAGE as an indicator of alcohol abuse and its consequences among undergraduate drinkers. (14574088)
2003
37
The long-term consequences of parental alcohol abuse: a cohort study of children in Denmark. (14629993)
2003
38
Differential associations of sex and D2 dopamine receptor (DRD2) genotype with negative affect and other substance abuse risk markers in children of alcoholics. (13679114)
2003
39
Novel and previously reported single-nucleotide polymorphisms in the human 5-HT(1B) receptor gene: no association with cocaine or alcohol abuse or dependence. (11496363)
2001
40
Examination of a CYP2E1 repeat polymorphism in a monkey model of alcohol abuse. (11505041)
2001
41
American Academy of Pediatrics. Committee on Substance Abuse and Committee on Children With Disabilities. Fetal alcohol syndrome and alcohol-related neurodevelopmental disorders. (10920168)
2000
42
A multicentre, randomized, double-blind, placebo-controlled trial of naltrexone in the treatment of alcohol dependence or abuse. (11093966)
2000
43
The abuse potential of zolpidem administered alone and with alcohol. (9610942)
1998
44
Free radicals and not acetaldehyde influence the circulating levels of glutathione after acute or chronic alcohol abuse: in vivo and in vitro studies. (9646199)
1997
45
Incidence of alcohol abuse among patients with emergency admissions to a psychiatric department. Evaluation based on clinical and biochemical markers]. (7645101)
1995
46
Pancreatic fibrosis in patients with chronic alcohol abuse: correlation with alcoholic pancreatitis. (7942737)
1994
47
The pharmacologic treatment of alcohol and cocaine abuse. Integration of recent findings into clinical practice. (1549545)
1992
48
A statistical evaluation of the literature regarding the associations among alcoholism, drug abuse, and antisocial personality disorder. (3066764)
1988
49
Intestinal pseudo-obstruction in alcohol abuse: report of two cases. (519478)
1979
50
Diazepam, alcohol, and barbiturate abuse. (5124414)
1971

Genetic Variations for Alcohol Abuse

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Expression for genes affiliated with Alcohol Abuse

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Sources:
1BioGPS, 15Gene Expression Omnibus DataSets
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Expression patterns in normal tissues for genes affiliated with Alcohol Abuse

Search GEO for disease gene expression data for Alcohol Abuse.

Pathways for genes affiliated with Alcohol Abuse

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Sources:
53Reactome, 37NCBI BioSystems Database, 29KEGG, 12EMD Millipore, 49PharmGKB
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Pathways related to Alcohol Abuse according to GeneCards/GeneDecks:

(show all 13)
idSuper pathways (with members indented)ScoreTop Affiliating Genes
1
Hide members
10.4ADH1C, ALDH2
2
Hide members
10.4CYP2E1, ALDH2
310.4DRD3, DRD2
4
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10.3ALDH2, ADH1C, ALDH9A1
5
Retinol metabolism
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10.3CYP2E1, ALDH9A1, ALDH2
6
Hide members
10.3CYP2E1, ALDH2, ALDH9A1
7
Hide members
10.3DRD2, DRD3, SLC6A4
810.3ALDH9A1, ALDH2, AKR1A1
9
Hide members
10.3CYP2E1, AKR1A1, ALDH2, ADH1C
10
Hide members
10.2AKR1A1, ALDH2, ALDH9A1, ADH1C
11
Hide members
10.2SLC6A4, DRD2, DRD3, COMT, CREB1
12
Hide members
10.2ALDH9A1, ALDH2, GGT1, ABCB7, GPT, ADH1C
13
Hide members
10.1AKR1A1, COMT, CYP2E1, GGT1, ALDH2, ADH1C

Compounds for genes affiliated with Alcohol Abuse

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44Novoseek, 11DrugBank, 24HMDB, 49PharmGKB, 28IUPHAR, 59Tocris Bioscience, 2BitterDB
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Compounds related to Alcohol Abuse according to GeneCards/GeneDecks:

(show top 50)    (show all 237)
idCompoundScoreTop Affiliating Genes
1vitamin a44 11 2412.6ADH1C, ALDH2, CYP2E1, AKR1A1, CREB1, LCAT
25-hydroxytryptophol4410.6AKR1A1, GPT, SLC17A5, ALDH9A1
3nash4410.6AKR1A1, CYP2E1, HFE, GPT, GGT1, SLC17A5
4rsai4410.6AKR1A1, CYP2E1, ALDH9A1, ADH1C, ALDH2, HFE
5methamphetamine44 49 1112.6SLC6A4, CREB1, RPS27A, DRD3, DRD2
6opiate4410.5CREB1, SLC17A5, SLC6A4, TF, GAL, DRD3
7vinylchloride4410.5GGT1, SLC17A5, CYP2E1, ALDH2
8risperidone28 44 49 59 11 2415.5SLC17A5, COMT, DRD2, DRD3, CREB1, GPT
9disulfiram44 59 1112.5ALDH2, SLC17A5, AKR1A1, GPT, GGT1, CYP2E1
10phenobarbital44 28 1112.5TF, AKR1A1, GPT, GGT1, ALDH9A1, CYP2E1
11alpha tocopherol4410.5TF, ALDH2, LCAT, CREB1
12heroin44 49 1112.5COMT, SLC17A5, DRD2, DRD3, SLC6A4
134-hydroxynonenal44 2411.5RPS27A, ALDH2, CYP2E1, LCAT, CREB1, AKR1A1
14bupropion44 49 11 2413.5CYP2E1, DRD3, DRD2, COMT, SLC6A4
15clozapine44 28 49 1113.5SLC6A4, COMT, GPT, DRD2, CYP2E1, DRD3
16choline44 11 2412.4COMT, GAL, TF, ADH1C, ALDH9A1, GGT1
17haloperidol44 28 2 49 1114.4AKR1A1, CREB1, GGT1, SLC6A4, GPT, DRD2
18acetaldehyde44 28 2412.4ADH1C, ALDH9A1, ALDH2, GGT1, SLC17A5, CYP2E1
19nicotine44 49 28 1113.4GGT1, SLC17A5, SLC6A4, GPT, CYP2E1, DRD3
20thyroxine44 2411.4SLC17A5, ABCB7, ALDH9A1, TF, GPT, COG2
21levodopa44 1111.4COMT, RPS27A, DRD2, DRD3, GAL, TF
22estrogen4410.4COG2, SLC6A4, LCAT
23cocaine44 1111.4COMT, DRD2, DRD3, GGT1, SLC17A5, SLC6A4
24epinephrine44 11 2412.4DRD2, SLC17A5, SLC6A4, CREB1, TF, GAL
25valproic acid44 49 11 2413.4COG2, GGT1, SLC17A5, CYP2E1, CREB1, GPT
26formaldehyde44 2411.4CYP2E1, GAL, AKR1A1, RPS27A, ALDH2, ALDH9A1
27ascorbic acid44 2411.4GGT1, DRD2, COMT, TF, HFE, LCAT
28gaba4410.4SLC6A4, AKR1A1, CREB1, ALDH9A1, DRD2, RPS27A
295-hydroxytryptamine4410.4COMT, AKR1A1, CREB1, GAL, DRD2, SLC6A4
30norepinephrine44 11 2412.4GAL, COMT, DRD2, CREB1, DRD3, TF
31n acetylcysteine4410.4RPS27A, AKR1A1, SLC17A5, TF, GGT1, ALDH9A1
32lactate4410.4GGT1, ALDH9A1, CYP2E1, GPT, AKR1A1, CREB1
33bezafibrate44 28 1112.4GGT1, SLC17A5, COG2, LCAT, GPT
34glutamine4410.3ALDH2, LCAT, TF, CREB1, SLC17A5, GPT
35creatinine4410.3COG2, RPS27A, ABCB7, SLC17A5, GPT, CYP2E1
36ethanol44 49 11 2413.3ALDH9A1, ADH1C, ABCB7, ALDH2, GGT1, SLC17A5
37polyacrylamide4410.3SLC17A5, ALDH2, ABCB7, ALDH9A1, LCAT, GAL
38glutamate4410.3SLC6A4, ABCB7, GPT, AKR1A1, GAL, DRD3
39aspartate4410.3GPT, ALDH9A1, RPS27A, TF, AKR1A1, HFE
40dopamine44 28 11 2413.3SLC6A4, ALDH9A1, ALDH2, GGT1, CYP2E1, AKR1A1
41ursodeoxycholic acid44 11 2412.2ABCB7, GPT, SLC17A5, GGT1, CYP2E1
42bromocriptine28 44 1112.2COMT, DRD2, GAL, CREB1, DRD3
43cholesterol44 28 11 2413.2ALDH2, GGT1, SLC17A5, ABCB7, HFE, TF
44testosterone44 59 11 2413.2GGT1, COG2, SLC17A5, SLC6A4, ABCB7, CYP2E1
45lipid4410.2GAL, ABCB7, GPT, CYP2E1, HFE, AKR1A1
46cysteine4410.2CYP2E1, HFE, AKR1A1, CREB1, DRD3, LCAT
47alanine4410.1GGT1, ALDH2, SLC17A5, SLC6A4, COG2, RPS27A
48iron44 2411.1GGT1, SLC17A5, COG2, HFE, ABCB7, GAL
49verapamil44 49 28 11 2414.1SLC6A4, CYP2E1, GPT, SLC17A5, AKR1A1, GGT1
50silymarin449.9GPT, SLC17A5, GGT1, CYP2E1, ABCB7

GO Terms for genes affiliated with Alcohol Abuse

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Sources:
16Gene Ontology
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Cellular components related to Alcohol Abuse according to GeneCards/GeneDecks:

idNameGO IDScoreTop Affiliating Genes
1basal part of cellGO:04517810.4HFE, TF
2endocytic vesicleGO:03013910.0TF, DRD3, DRD2

Biological processes related to Alcohol Abuse according to GeneCards/GeneDecks:

(show all 19)
idNameGO IDScoreTop Affiliating Genes
1negative regulation of dopamine receptor signaling pathwayGO:06016010.7DRD3, DRD2
2response to histamineGO:03477610.6DRD3, DRD2
3regulation of dopamine uptake involved in synaptic transmissionGO:05158410.6DRD2, DRD3
4regulation of cAMP metabolic processGO:03081410.6DRD2, DRD3
5adenylate cyclase-inhibiting dopamine receptor signaling pathwayGO:00719510.6DRD2, DRD3
6neurotransmitter biosynthetic processGO:04213610.6ALDH2, COMT, ALDH9A1
7dopamine metabolic processGO:04241710.6DRD2, DRD3
8cellular iron ion homeostasisGO:00687910.6TF, ABCB7, HFE
9regulation of dopamine secretionGO:01405910.5DRD3, DRD2
10xenobiotic metabolic processGO:00680510.5COMT, CYP2E1, GGT1, ALDH2, ADH1C
11synaptic transmission, dopaminergicGO:00196310.5DRD2, DRD3
12G-protein coupled receptor internalizationGO:00203110.5DRD3, DRD2
13response to drugGO:04249310.4SLC6A4, COMT, DRD2, GAL, DRD3, CREB1
14cellular aldehyde metabolic processGO:00608110.4ALDH9A1, AKR1A1
15negative regulation of protein secretionGO:05070910.4DRD3, DRD2
16prepulse inhibitionGO:06013410.4DRD3, DRD2
17small molecule metabolic processGO:04428110.3COMT, LCAT, ADH1C, ALDH9A1, CYP2E1, ALDH2
18behavioral response to cocaineGO:04814810.3DRD2, DRD3
19ethanol oxidationGO:00606910.1ADH1C, ALDH2

Molecular functions related to Alcohol Abuse according to GeneCards/GeneDecks:

idNameGO IDScoreTop Affiliating Genes
1dopamine bindingGO:03524010.4DRD3, DRD2
2dopamine neurotransmitter receptor activity, coupled via Gi/GoGO:00159110.1DRD3, DRD2

Products for genes affiliated with Alcohol Abuse

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  • Antibodies
  • Proteins
  • Lysates
  • Antibodies

Sources for Alcohol Abuse

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3CDC
13ExPASy
14FMA
22GTR
23HGMD
24HMDB
25ICD10
26ICD10 via Orphanet
27ICD9CM
28IUPHAR
29KEGG
34MeSH
35MESH via Orphanet
36MGI
39NCIt
40NDF-RT
43NINDS
44Novoseek
46OMIM
47OMIM via Orphanet
50PubMed
51QIAGEN
57SNOMED-CT via Orphanet
60UMLS
61UMLS via Orphanet