MCID: ALC004
MIFTS: 55

Alcohol Abuse malady

Summaries for Alcohol Abuse

Sources:
8Disease Ontology, 64Wikipedia, 33MalaCards
See all sources

Fully expand this MalaCard

Export this MalaCard
Wikipedia:64 Alcohol abuse, as described in the DSM-IV, is a psychiatric diagnosis describing the recurring use of... more...

MalaCards: Alcohol Abuse, also known as ethanol abuse, is related to alcohol dependence and substance abuse. An important gene associated with Alcohol Abuse is ABCB7 (ATP-binding cassette, sub-family B (MDR/TAP), member 7), and among its related pathways are Cytochrome P450 - arranged by substrate type and ethanol degradation II. The compounds vitamin a and 5-hydroxytryptophol have been mentioned in the context of this disorder. Affiliated tissues include liver, brain and lung, and related mouse phenotypes are cardiovascular system and growth/size.

Disease Ontology:8 A substance abuse that involves the recurring use of alcoholic beverages despite negative consequences.

Aliases & Classifications for Alcohol Abuse

Sources:
8Disease Ontology, 45Novoseek, 61UMLS, 27ICD9CM, 35MeSH, 57SNOMED-CT, 40NCIt
See all sources

Aliases & Descriptions:

alcohol abuse 8 45 61
ethanol abuse 8


External Ids:

Disease Ontology8 DOID:1574
ICD9CM27 305.0, 305.00
SNOMED-CT57 304606004, 15167005
MeSH35 D000437
NCIt40 C20701

Related Diseases for Alcohol Abuse

Sources:
17GeneCards, 18GeneDecks
See all sources

Diseases in the Alcohol Abuse family:

alcohol sensitivity, acute

Diseases related to Alcohol Abuse via text searches within MalaCards or GeneCards/GeneDecks gene sharing:

(show top 50)    (show all 193)
idRelated DiseaseScoreTop Affiliating Genes
1alcohol dependence31.5ALDH2, GGT1, SLC6A4, TF, DRD2
2substance abuse30.8ALDH2, GGT1, SLC6A4, CYP2E1, TF, DRD3
3hepatitis c30.7GGT1, SLC17A5, ABCB7, GPT, CYP2E1, HFE
4cocaine abuse30.6SLC6A4, DRD2
5viral hepatitis30.5GGT1, SLC17A5, ABCB7, GPT, HFE, AKR1A1
6bipolar disorder30.5SLC6A4, CREB1, DRD3, DRD2, COMT
7alcoholic pancreatitis30.4ADH1C, ALDH9A1, ALDH2, CYP2E1, AKR1A1
8anxiety disorder30.3SLC6A4
9pathological gambling30.3DRD3, DRD2
10cocaine dependence30.3SLC6A4, DRD3, DRD2
11conduct disorder30.3SLC6A4, DRD2, COMT
12coronary heart disease30.2ADH1C, GGT1, HFE, AKR1A1, LCAT, COMT
13alcoholic liver cirrhosis30.2ADH1C, ALDH9A1, ALDH2, GGT1, SLC17A5, GPT
14sickle cell disease30.0TF
15infertility30.0RPS27A
16asthma30.0ALDH2, CYP2E1
17antisocial personality disorder30.0SLC6A4, DRD2
18tuberculosis30.0CYP2E1, AKR1A1, CREB1
19panic disorder30.0SLC6A4, COMT
20anorexia nervosa30.0SLC6A4, GAL, COMT
21hepatitis b30.0GGT1, SLC17A5, ABCB7, GPT
22deficiency anemia30.0ABCB7, HFE, TF, LCAT
23alcoholic hepatitis30.0GGT1, SLC17A5, GPT, RPS27A
24acute pancreatitis30.0ADH1C, ALDH2, SLC17A5, ABCB7, GPT
25drug addiction30.0CREB1, DRD3, DRD2
26pancreatitis, chronic30.0ADH1C, ALDH9A1, ALDH2, CYP2E1, AKR1A1
27wilson disease30.0SLC17A5, GPT, HFE, TF, DRD2
28hepatitis e30.0GPT
29substance dependence30.0SLC6A4, DRD3, DRD2, COMT
30brain disease30.0SLC17A5, ABCB7, GPT
31mental retardation30.0CREB1, DRD2, COMT
32leukopenia30.0SLC17A5, ABCB7, GPT
33hepatitis a10.6
34hepatitis d10.5
35wernicke-korsakoff syndrome10.4
36brain injury10.4
37traumatic brain injury10.3
38opioid abuse10.2
39madelung disease10.2
40chronic pain10.2
41hepatitis c virus10.2
42sepsis10.2
43bone fracture10.0
44burns10.0
45atrioventricular block10.0
46axonal neuropathy10.0
47pulmonary tuberculosis10.0
48osteonecrosis10.0
49sensorineural hearing loss10.0
50pulmonary edema10.0

Graphical network of the top 20 diseases related to Alcohol Abuse:



Diseases related to alcohol abuse

Clinical Features for Alcohol Abuse

Drugs & Therapeutics for Alcohol Abuse

Sources:
5CenterWatch, 42NIH Clinical Center, 6ClinicalTrials, 61UMLS, 41NDF-RT
See all sources

Approved drugs:

Search CenterWatch for Alcohol Abuse

Drug clinical trials:

Search ClinicalTrials for Alcohol Abuse

Search NIH Clinical Center for Alcohol Abuse

Search CenterWatch for Alcohol Abuse

Genetic Tests for Alcohol Abuse

Anatomical Context for Alcohol Abuse

Sources:
33MalaCards
See all sources

MalaCards organs/tissues related to Alcohol Abuse:

33
Liver, Brain, Lung, Whole blood, Thymus, Cortex, Heart, Breast, B cells, Endothelial, Fetal brain, Prefrontal cortex, Amygdala, Fetal liver, Fetal lung

Animal Models for Alcohol Abuse or affiliated genes

Sources:
37MGI, 28inGenious Targeting Laboratory
See all sources

Publications for Alcohol Abuse

Sources:
51PubMed
See all sources

Articles related to Alcohol Abuse:

(show top 50)    (show all 649)
idTitleAuthorsYear
1
Mental Health and Migration: Depression, Alcohol Abuse, and Access to Health Care Among Migrants in Central Asia. (24186359)
2013
2
The importance of alcohol abuse and smoking in the evolution of glaucoma disease. (23904887)
2013
3
Alcohol abuse-related severe acute pancreatitis with rhabdomyolysis complications. (23251265)
2013
4
Giant cell myocarditis and endomyocardial calcification in a 2.5-month-old infant triggered by excessive maternal alcohol abuse: case study of an unusual association. (23341052)
2013
5
Low and moderate alcohol consumption during pregnancy: effects on social behaviour and propensity to develop substance abuse in later life. (23164117)
2012
6
Introduction to the special issue "Pharmacotherapies for the treatment of alcohol abuse and dependence" and a summary of patents targeting other neurotransmitter systems. (22574678)
2012
7
Alcohol and substance abuse identified during pregnancy: maternal morbidity, child morbidity and welfare interventions. (22429257)
2012
8
The role of biogenic amine signaling in the bed nucleus of the stria terminals in alcohol abuse. (22449787)
2012
9
The effect of alcohol abuse and alcohol withdrawal on short-term outcomes and cost of care after head and neck cancer surgery. (22566069)
2012
10
Getting a grip on drinking behavior: training working memory to reduce alcohol abuse. (21685380)
2011
11
A review of technology-assisted self-help and minimal contact therapies for drug and alcohol abuse and smoking addiction: is human contact necessary for therapeutic efficacy? (21095051)
2011
12
Prevalence and correlates of DSM-IV alcohol abuse and dependence in Australia: findings of the 2007 National Survey of Mental Health and Wellbeing. (20707771)
2010
13
Comorbidity of generalized anxiety disorder and alcohol use disorders among individuals seeking outpatient substance abuse treatment. (19733441)
2010
14
Evolving therapeutic indications for N-type calcium channel blockers: from chronic pain to alcohol abuse. (21426203)
2010
15
The effects of self-efficacy statements in humorous anti-alcohol abuse messages targeting college students: who is in charge? (21153979)
2010
16
Genes associated with alcohol abuse and tobacco smoking in the human nucleus accumbens and ventral tegmental area. (20477762)
2010
17
Sexual risk behaviors, alcohol abuse, and intimate partner violence among sex workers in Mongolia: implications for HIV prevention intervention development. (20391057)
2010
18
Strategy for increasing detection rates of drug and alcohol abuse in paediatric emergency departments. (19555445)
2009
19
Relationships between parental alcohol abuse and social support, peer substance abuse risk and social support, and substance abuse risk among South Korean adolescents. (19435169)
2009
20
A proteomic workflow for discovery of serum carrier protein-bound biomarker candidates of alcohol abuse using LC-MS/MS. (19544491)
2009
21
Ethical considerations for administering alcohol or alcohol cues to treatment-seeking alcoholics in a research setting: can the benefits to society outweigh the risks to the individual? A commentary in the context of the National Advisory Council on Alcohol Abuse and Alcoholism -- Recommended Council Guidelines on Ethyl Alcohol Administration in Human Experimentation (2005). (19519721)
2009
22
Conceptualizing impulsivity and risk taking in bipolar disorder: importance of history of alcohol abuse. (19133964)
2009
23
Association of the functional serotonin transporter promoter polymorphism (5-HTTLPR) with externalizing and internalizing aggressivity and alcohol abuse]. (19331786)
2008
24
Interaction between a functional MAOA locus and childhood sexual abuse predicts alcoholism and antisocial personality disorder in adult women. (17592478)
2008
25
Alcohol abuse/dependence symptoms among hospital employees exposed to a SARS outbreak. (18790829)
2008
26
Ethnic differences in the predictors of drug and alcohol abuse in hospitalized adolescents. (17882610)
2007
27
Study of dopamine receptors genes polymorphisms in bipolar patients with comorbid alcohol abuse. (17158525)
2007
28
Maternal alcohol abuse/dependence, children's behavior problems, and home environment: estimates from the National Longitudinal Survey of Youth using propensity score matching. (17286345)
2007
29
Prevalence and severity of intimate partner violence and associations with family functioning and alcohol abuse in psychiatric inpatients with suicidal intent. (16426084)
2006
30
Update from Sri Lankan Twin Registry: establishment of a population-based twin register and ongoing project on common mental disorders, alcohol abuse and suicidal ideations. (17254423)
2006
31
Alcohol abuse and dependence in college and noncollege samples: A ten-year prospective follow-up in a national survey. (17060996)
2006
32
Alcohol drinking habits and community perspectives on alcohol abuse in the Bella Coola Valley. (16454968)
2006
33
Alcohol abuse and risk behavior among adolescents in larger cities in Bosnia and Herzegovina. (15997674)
2005
34
Revealing alcohol abuse: to ask or to test? (16088981)
2005
35
Epidemiology of sepsis: race, sex, and chronic alcohol abuse. (16237652)
2005
36
What are the treatment options for comorbid alcohol abuse and depressive disorders? (15944746)
2005
37
Determining positivity of alcohol abuse by Taguchi methods. (15974502)
2005
38
Alcohol abuse among patients with and without HIV infection attending public clinics in western Kenya. (15868970)
2004
39
Maternal age, alcohol abuse history, and quality of parenting as moderators of the effects of prenatal alcohol exposure on 7.5-year intellectual function. (15547461)
2004
40
Differential effects of alcohol, cocaine, and opioid abuse on event-related potentials recorded during a response competition task. (11906801)
2002
41
Individual susceptibility to Wernicke-Korsakoff syndrome and alcoholism-induced cognitive deficit: impaired thiamine utilization found in alcoholics and alcohol abusers. (12454526)
2002
42
Biochemical detection and monitoring of alcohol abuse and abstinence. (11732647)
2001
43
A multicentre, randomized, double-blind, placebo-controlled trial of naltrexone in the treatment of alcohol dependence or abuse. (11093966)
2000
44
Psychopathology in adolescent alcohol abuse and dependence. (15706785)
1998
45
The abuse potential of zolpidem administered alone and with alcohol. (9610942)
1998
46
Incidence of alcohol abuse among patients with emergency admissions to a psychiatric department. Evaluation based on clinical and biochemical markers]. (7645101)
1995
47
Pancreatic fibrosis in patients with chronic alcohol abuse: correlation with alcoholic pancreatitis. (7942737)
1994
48
American Academy of Pediatrics Committee on Substance Abuse and Committee on Children with Disabilities: Fetal alcohol syndrome and fetal alcohol effects. (8507280)
1993
49
Alcohol and cocaine abuse. A comparison of epidemiology and clinical characteristics. (1317046)
1992
50
Serum type III procollagen peptide and laminin (Lam-P1) detect alcoholic hepatitis in chronic alcohol abusers. (2707736)
1989

Genetic Variations for Alcohol Abuse

Expression for genes affiliated with Alcohol Abuse

Sources:
1BioGPS, 15Gene Expression Omnibus DataSets
See all sources
Expression patterns in normal tissues for genes affiliated with Alcohol Abuse

Search GEO for disease gene expression data for Alcohol Abuse.

Pathways for genes affiliated with Alcohol Abuse

Sources:
54Reactome, 38NCBI BioSystems Database, 30KEGG, 12EMD Millipore, 50PharmGKB
See all sources

Pathways related to Alcohol Abuse according to GeneCards/GeneDecks:

(show all 13)
idSuper pathways (with members indented)ScoreTop Affiliating Genes
1
Hide members
10.4ADH1C, ALDH2
2
Hide members
10.4CYP2E1, ALDH2
310.4DRD3, DRD2
4
Hide members
10.3ALDH2, ADH1C, ALDH9A1
5
Retinol metabolism
Hide members
10.3CYP2E1, ALDH9A1, ALDH2
6
Hide members
10.3CYP2E1, ALDH2, ALDH9A1
7
Hide members
10.3DRD2, DRD3, SLC6A4
810.3ALDH9A1, ALDH2, AKR1A1
9
Hide members
10.3CYP2E1, AKR1A1, ALDH2, ADH1C
10
Hide members
10.2AKR1A1, ALDH2, ALDH9A1, ADH1C
11
Hide members
10.2SLC6A4, DRD2, DRD3, COMT, CREB1
12
Hide members
10.2ALDH9A1, ALDH2, GGT1, ABCB7, GPT, ADH1C
13
Hide members
10.1AKR1A1, COMT, CYP2E1, GGT1, ALDH2, ADH1C

Compounds for genes affiliated with Alcohol Abuse

Sources:
45Novoseek, 11DrugBank, 24HMDB, 50PharmGKB, 29IUPHAR, 60Tocris Bioscience, 2BitterDB
See all sources

Compounds related to Alcohol Abuse according to GeneCards/GeneDecks:

(show top 50)    (show all 237)
idCompoundScoreTop Affiliating Genes
1vitamin a45 11 2412.6ADH1C, ALDH2, CYP2E1, AKR1A1, CREB1, LCAT
25-hydroxytryptophol4510.6AKR1A1, GPT, SLC17A5, ALDH9A1
3nash4510.6AKR1A1, CYP2E1, HFE, GPT, GGT1, SLC17A5
4rsai4510.6AKR1A1, CYP2E1, ALDH9A1, ADH1C, ALDH2, HFE
5methamphetamine45 50 1112.6SLC6A4, CREB1, RPS27A, DRD3, DRD2
6opiate4510.5CREB1, SLC17A5, SLC6A4, TF, GAL, DRD3
7vinylchloride4510.5GGT1, SLC17A5, CYP2E1, ALDH2
8risperidone29 45 50 60 11 2415.5SLC17A5, COMT, DRD2, DRD3, CREB1, GPT
9disulfiram45 60 1112.5ALDH2, SLC17A5, AKR1A1, GPT, GGT1, CYP2E1
10phenobarbital45 29 1112.5TF, AKR1A1, GPT, GGT1, ALDH9A1, CYP2E1
11alpha tocopherol4510.5TF, ALDH2, LCAT, CREB1
12heroin45 50 1112.5COMT, SLC17A5, DRD2, DRD3, SLC6A4
134-hydroxynonenal45 2411.5RPS27A, ALDH2, CYP2E1, LCAT, CREB1, AKR1A1
14bupropion45 50 11 2413.5CYP2E1, DRD3, DRD2, COMT, SLC6A4
15clozapine45 29 50 1113.5SLC6A4, COMT, GPT, DRD2, CYP2E1, DRD3
16choline45 11 2412.4COMT, GAL, TF, ADH1C, ALDH9A1, GGT1
17haloperidol45 29 2 50 1114.4AKR1A1, CREB1, GGT1, SLC6A4, GPT, DRD2
18acetaldehyde45 29 2412.4ADH1C, ALDH9A1, ALDH2, GGT1, SLC17A5, CYP2E1
19nicotine45 50 29 1113.4GGT1, SLC17A5, SLC6A4, GPT, CYP2E1, DRD3
20thyroxine45 2411.4SLC17A5, ABCB7, ALDH9A1, TF, GPT, COG2
21levodopa45 1111.4COMT, RPS27A, DRD2, DRD3, GAL, TF
22estrogen4510.4COG2, SLC6A4, LCAT
23cocaine45 1111.4COMT, DRD2, DRD3, GGT1, SLC17A5, SLC6A4
24epinephrine45 11 2412.4DRD2, SLC17A5, SLC6A4, CREB1, TF, GAL
25valproic acid45 50 11 2413.4COG2, GGT1, SLC17A5, CYP2E1, CREB1, GPT
26formaldehyde45 2411.4CYP2E1, GAL, AKR1A1, RPS27A, ALDH2, ALDH9A1
27ascorbic acid45 2411.4GGT1, DRD2, COMT, TF, HFE, LCAT
28gaba4510.4SLC6A4, AKR1A1, CREB1, ALDH9A1, DRD2, RPS27A
295-hydroxytryptamine4510.4COMT, AKR1A1, CREB1, GAL, DRD2, SLC6A4
30norepinephrine45 11 2412.4GAL, COMT, DRD2, CREB1, DRD3, TF
31n acetylcysteine4510.4RPS27A, AKR1A1, SLC17A5, TF, GGT1, ALDH9A1
32lactate4510.4GGT1, ALDH9A1, CYP2E1, GPT, AKR1A1, CREB1
33bezafibrate45 29 1112.4GGT1, SLC17A5, COG2, LCAT, GPT
34glutamine4510.3ALDH2, LCAT, TF, CREB1, SLC17A5, GPT
35creatinine4510.3COG2, RPS27A, ABCB7, SLC17A5, GPT, CYP2E1
36ethanol45 50 11 2413.3ALDH9A1, ADH1C, ABCB7, ALDH2, GGT1, SLC17A5
37polyacrylamide4510.3SLC17A5, ALDH2, ABCB7, ALDH9A1, LCAT, GAL
38glutamate4510.3SLC6A4, ABCB7, GPT, AKR1A1, GAL, DRD3
39aspartate4510.3GPT, ALDH9A1, RPS27A, TF, AKR1A1, HFE
40dopamine45 29 11 2413.3SLC6A4, ALDH9A1, ALDH2, GGT1, CYP2E1, AKR1A1
41ursodeoxycholic acid45 11 2412.2ABCB7, GPT, SLC17A5, GGT1, CYP2E1
42bromocriptine29 45 1112.2COMT, DRD2, GAL, CREB1, DRD3
43cholesterol45 29 11 2413.2ALDH2, GGT1, SLC17A5, ABCB7, HFE, TF
44testosterone45 60 11 2413.2GGT1, COG2, SLC17A5, SLC6A4, ABCB7, CYP2E1
45lipid4510.2GAL, ABCB7, GPT, CYP2E1, HFE, AKR1A1
46cysteine4510.2CYP2E1, HFE, AKR1A1, CREB1, DRD3, LCAT
47alanine4510.1GGT1, ALDH2, SLC17A5, SLC6A4, COG2, RPS27A
48iron45 2411.1GGT1, SLC17A5, COG2, HFE, ABCB7, GAL
49verapamil45 50 29 11 2414.1SLC6A4, CYP2E1, GPT, SLC17A5, AKR1A1, GGT1
50silymarin459.9GPT, SLC17A5, GGT1, CYP2E1, ABCB7

GO Terms for genes affiliated with Alcohol Abuse

Sources:
16Gene Ontology
See all sources

Cellular components related to Alcohol Abuse according to GeneCards/GeneDecks:

idNameGO IDScoreTop Affiliating Genes
1basal part of cellGO:04517810.4HFE, TF
2endocytic vesicleGO:03013910.0TF, DRD3, DRD2

Biological processes related to Alcohol Abuse according to GeneCards/GeneDecks:

(show all 19)
idNameGO IDScoreTop Affiliating Genes
1negative regulation of dopamine receptor signaling pathwayGO:06016010.7DRD2, DRD3
2response to histamineGO:03477610.6DRD2, DRD3
3regulation of dopamine uptake involved in synaptic transmissionGO:05158410.6DRD3, DRD2
4regulation of cAMP metabolic processGO:03081410.6DRD2, DRD3
5adenylate cyclase-inhibiting dopamine receptor signaling pathwayGO:00719510.6DRD2, DRD3
6neurotransmitter biosynthetic processGO:04213610.6ALDH9A1, ALDH2, COMT
7dopamine metabolic processGO:04241710.6DRD2, DRD3
8cellular iron ion homeostasisGO:00687910.6ABCB7, HFE, TF
9regulation of dopamine secretionGO:01405910.5DRD2, DRD3
10xenobiotic metabolic processGO:00680510.5COMT, CYP2E1, GGT1, ALDH2, ADH1C
11negative regulation of protein secretionGO:05070910.5DRD2, DRD3
12behavioral response to cocaineGO:04814810.5DRD2, DRD3
13response to drugGO:04249310.4SLC6A4, CYP2E1, CREB1, GAL, DRD3, DRD2
14cellular aldehyde metabolic processGO:00608110.4AKR1A1, ALDH9A1
15ethanol oxidationGO:00606910.4ALDH2, ADH1C
16prepulse inhibitionGO:06013410.4DRD3, DRD2
17small molecule metabolic processGO:04428110.3COMT, LCAT, CYP2E1, GPT, ABCB7, GGT1
18G-protein coupled receptor internalizationGO:00203110.3DRD2, DRD3
19synaptic transmission, dopaminergicGO:00196310.1DRD2, DRD3

Molecular functions related to Alcohol Abuse according to GeneCards/GeneDecks:

idNameGO IDScoreTop Affiliating Genes
1dopamine bindingGO:03524010.4DRD3, DRD2
2dopamine neurotransmitter receptor activity, coupled via Gi/GoGO:00159110.1DRD3, DRD2

Products for genes affiliated with Alcohol Abuse

  • Antibodies
  • Proteins
  • Lysates
  • Antibodies

Sources for Alcohol Abuse

3CDC
13ExPASy
14FMA
22GTR
23HGMD
24HMDB
25ICD10
26ICD10 via Orphanet
27ICD9CM
29IUPHAR
30KEGG
35MeSH
36MESH via Orphanet
37MGI
40NCIt
41NDF-RT
44NINDS
45Novoseek
47OMIM
48OMIM via Orphanet
51PubMed
52QIAGEN
58SNOMED-CT via Orphanet
61UMLS
62UMLS via Orphanet