MCID: ALC004
MIFTS: 51

Alcohol Abuse malady

Mental diseases category

Summaries for Alcohol Abuse

About this section
Sources:
9Disease Ontology, 66Wikipedia, 34MalaCards
See all sources

Fully expand this MalaCard

Download this MalaCard
Wikipedia:66 Alcohol abuse, as described in the DSM-IV, is a psychiatric diagnosis describing the recurring use of... more...

MalaCards: Alcohol Abuse, also known as ethanol abuse, is related to alcohol dependence and hepatitis. An important gene associated with Alcohol Abuse is ABCB7 (ATP-binding cassette, sub-family B (MDR/TAP), member 7), and among its related pathways are Transport of glucose and other sugars, bile salts and organic acids, metal ions and amine compounds and Fatty acid metabolism. The compounds 5-hydroxytryptophol and alpha-hydroxybutyrate have been mentioned in the context of this disorder. Affiliated tissues include liver, brain and testes, and related mouse phenotypes are growth/size/body and homeostasis/metabolism.

Disease Ontology:9 A substance abuse that involves the recurring use of alcoholic beverages despite negative consequences.

Aliases & Classifications for Alcohol Abuse

About this section
Sources:
9Disease Ontology, 46Novoseek, 63UMLS, 59SNOMED-CT, 41NCIt, 28ICD9CM, 36MeSH
See all sources

Classifications:

Malacards categories (disease lists): (See all malacards categories)
Anatomical: Mental diseases


Aliases & Descriptions:

alcohol abuse 9 46 63
ethanol abuse 9


External Ids:

Disease Ontology9 DOID:1574
NCIt41 C20701
SNOMED-CT59 304606004, 15167005
ICD9CM28 305.00, 305.0
MeSH36 D000437

Related Diseases for Alcohol Abuse

About this section
Sources:
18GeneCards, 19GeneDecks
See all sources

Diseases in the Alcohol Abuse family:

Alcohol Sensitivity, Acute

Diseases related to Alcohol Abuse via text searches within MalaCards or GeneCards/GeneDecks gene sharing:

(show top 50)    (show all 131)
idRelated DiseaseScoreTop Affiliating Genes
1alcohol dependence31.0TF, ALDH2
2hepatitis31.0SLC17A5, GPT
3viral hepatitis30.5GPT, SLC17A5, ABCB7
4pancreatitis30.5CYP2E1, ADH1C, ALDH2, SLC17A5
5hepatocellular carcinoma30.4GPT, ALDH2, SLC17A5, CYP2E1, TF, ABCB7
6substance abuse30.4DRD3, TF, CYP2E1, ALDH2
7hepatitis c30.3TF, ABCB7, GPT, SLC17A5, CYP2E1
8alcoholic pancreatitis30.2ALDH2, ADH1C, CYP2E1
9alcoholic hepatitis30.1SLC17A5, GPT
10hepatitis b30.1GPT, ABCB7, SLC17A5
11leukopenia30.1ABCB7, SLC17A5, GPT
12liver cirrhosis30.0ABCB7, TF, CYP2E1, GPT, SLC17A5, ADH1C
13acute pancreatitis29.9ALDH2, ABCB7, GPT, ADH1C, SLC17A5
14obesity29.9ALDH2, ABCB7, CYP2E1, SLC17A5, GPT
15alcoholic liver cirrhosis29.8SLC17A5, ALDH2, ADH1C, TF, CYP2E1, GPT
16liver disease10.5
17schizophrenia10.4
18wernicke-korsakoff syndrome10.4
19bipolar disorder10.3
20brain injury10.3
21traumatic brain injury10.3
22personality disorder10.3
23pneumonia10.3
24neuronitis10.2
25pathological gambling10.2
26eating disorder10.2
27esophagitis10.2
28neuropathy10.2
29madelung disease10.2
30sepsis10.2
31hiv/aids10.2
32fatty liver disease10.1CYP2E1
33dengue disease10.1ABCB7, SLC17A5
34pyridoxine deficiency10.0GPT, SLC17A5
35obstructive jaundice10.0GPT, SLC17A5
36burns10.0
37atrioventricular block10.0
38axonal neuropathy10.0
39pulmonary tuberculosis10.0
40antisocial personality disorder10.0
41granulomatous hepatitis10.0
42alexithymia10.0
43frontotemporal dementia10.0
44conduct disorder10.0
45panic disorder10.0
46central pontine myelinolysis10.0
47cocaine dependence10.0
48cocaine abuse10.0
49anorexia nervosa10.0
50infertility10.0

Graphical network of the top 20 diseases related to Alcohol Abuse:



Diseases related to alcohol abuse

Symptoms for Alcohol Abuse

About this section

Drugs & Therapeutics for Alcohol Abuse

About this section
Sources:
6CenterWatch, 43NIH Clinical Center, 7ClinicalTrials, 63UMLS, 42NDF-RT
See all sources

Approved drugs:

Search CenterWatch for Alcohol Abuse

Drug clinical trials:

Search ClinicalTrials for Alcohol Abuse

Search NIH Clinical Center for Alcohol Abuse

Search CenterWatch for Alcohol Abuse

Genetic Tests for Alcohol Abuse

About this section

Anatomical Context for Alcohol Abuse

About this section
Sources:
34MalaCards
See all sources

MalaCards organs/tissues related to Alcohol Abuse:

34
Liver, Brain, Testes, Lung, Heart, Bone, Amygdala, Cortex, Endothelial, Breast, Thymus, Whole blood, Prefrontal cortex

Animal Models for Alcohol Abuse or affiliated genes

About this section
Sources:
38MGI
See all sources

MGI Mouse Phenotypes related to Alcohol Abuse:

38
idDescriptionMGI Source AccessionScoreTop Affiliating Genes
1MP:00053787.5SLC17A5, DRD3, ALDH2, ADH1C, TF, ABCB7
2MP:00053766.9SLC17A5, ABCB7, TF, CYP2E1, ADH1C, ALDH2
3MP:00107686.7ABCB7, TF, CYP2E1, ADH1C, ALDH2, DRD3

Publications for Alcohol Abuse

About this section
Sources:
53PubMed
See all sources

Articles related to Alcohol Abuse:

(show top 50)    (show all 559)
idTitleAuthorsYear
1
2013 reviewers, the american journal of drug and alcohol abuse. (24359510)
2014
2
Mental Health and Migration: Depression, Alcohol Abuse, and Access to Health Care Among Migrants in Central Asia. (24186359)
2013
3
Cardiovascular morbidity, risk of cancer and alcohol abuse in psoriasis: systematic literature reviews and expert opinion. (23845147)
2013
4
Suicide behavior in parents with alcohol abuse problems and suicide behavior in their offspring-adult offspring and counselor perspectives. (22283687)
2012
5
Patterns of protective factors in an intervention for the prevention of suicide and alcohol abuse with Yup'ik Alaska Native youth. (22931082)
2012
6
Protein biomarkers of alcohol abuse. (22967079)
2012
7
Use of the screening suggested by the National Institute on Alcohol Abuse and Alcoholism and of a newly derived tool for the detection of unhealthy alcohol drinkers among surgical patients. (22152670)
2012
8
A mouse model for adolescent alcohol abuse: stunted growth and effects in brain. (22433022)
2012
9
Central American mothers report family history of depression and alcohol abuse as a predictor of teenage health risk behaviors. (21040088)
2010
10
Suicidal behavior and alcohol abuse. (20617037)
2010
11
Parent training with behavioral couples therapy for fathers' alcohol abuse: effects on substance use, parental relationship, parenting, and CPS involvement. (19502478)
2009
12
Strategy for increasing detection rates of drug and alcohol abuse in paediatric emergency departments. (19555445)
2009
13
Suicidal behavior in adolescents with comorbid depression and alcohol abuse. (19461576)
2009
14
Alcohol abuse may lead to depression. (19662693)
2009
15
Correlates of and relationship among lifetime alcohol abuse and alcohol dependence in older community residents in Brazil. (20191090)
2009
16
Biochemical and neurotransmitter changes implicated in alcohol-induced brain damage in chronic or 'binge drinking' alcohol abuse. (19155229)
2009
17
Alcohol abuse enhances pulmonary edema in acute respiratory distress syndrome. (19572988)
2009
18
Elevated adiponectin serum levels in patients with chronic alcohol abuse rapidly decline during alcohol withdrawal. (19067777)
2009
19
Alcohol abuse in adolescents. (18305075)
2008
20
Pilot study of interpersonal psychotherapy versus supportive psychotherapy for dysthymic patients with secondary alcohol abuse or dependence. (18552624)
2008
21
Association of the functional serotonin transporter promoter polymorphism (5-HTTLPR) with externalizing and internalizing aggressivity and alcohol abuse]. (19331786)
2008
22
Alcohol abuse in sickle cell disease: the Pisces Project. (17882609)
2007
23
Cognitive function in older diabetic subjects with a history of alcohol abuse. (18361128)
2007
24
Increased fibronectin expression in lung in the setting of chronic alcohol abuse. (17374047)
2007
25
Death from seizures induced by chronic alcohol abuse--does it exist? (17383203)
2007
26
Alcohol drinking patterns and prevalence of alcohol-abuse and dependence in the Israel National Health Survey. (18080649)
2007
27
Pneumococcal meningitis in community is frequent after craniocerebral trauma and in alcohol abusers. (18030267)
2007
28
Short-term neuropsychological outcome following uncomplicated mild TBI: effects of day-of-injury intoxication and pre-injury alcohol abuse. (17784807)
2007
29
Prevalence and severity of intimate partner violence and associations with family functioning and alcohol abuse in psychiatric inpatients with suicidal intent. (16426084)
2006
30
Alcohol abuse as a risk factor for ARDS]. (17176845)
2006
31
The role played by a former federal government residential school in a First Nation community's alcohol abuse and impaired driving: results of a talking circle. (17131973)
2006
32
Alcohol abuse and risk behavior among adolescents in larger cities in Bosnia and Herzegovina. (15997674)
2005
33
Alcohol abuse screening in primary care. (15702019)
2005
34
Strategies to study human serum transferrin isoforms using integrated liquid chromatography ICPMS, MALDI-TOF, and ESI-Q-TOF detection: application to chronic alcohol abuse. (16131073)
2005
35
Patterns of alcohol consumption in bipolar patients comorbid for alcohol abuse or dependence. (16026491)
2005
36
Should nurses be randomly tested for alcohol abuse? (16116365)
2005
37
Rhabdomyolysis and acute renal failure after strenuous exercise and alcohol abuse: case report and literature review. (15821814)
2005
38
CUGE: a screening instrument for alcohol abuse and dependence in students. (15289205)
2004
39
Alcohol abuse among patients with and without HIV infection attending public clinics in western Kenya. (15868970)
2004
40
Depression, alcohol abuse, and generational differences in Mazahua women in a rural Mexican village. (15371136)
2004
41
Alcohol use disorders and mood disorders: a National Institute on Alcohol Abuse and Alcoholism perspective. (15556112)
2004
42
The co-occurrence of DSM-IV alcohol abuse in DSM-IV alcohol dependence: results of the National Epidemiologic Survey on Alcohol and Related Conditions on heterogeneity that differ by population subgroup. (15351767)
2004
43
Synthesis of daidzin analogues as potential agents for alcohol abuse. (12927869)
2003
44
Spectral analyses of sleep EEG in depressed offspring of fathers with or without a positive history of alcohol abuse or dependence: a pilot study. (13679113)
2003
45
Rhabdomyolysis, hepatitis and multiple hematological disorders associated with alcohol abuse: a case report. (12939102)
2002
46
Novel and previously reported single-nucleotide polymorphisms in the human 5-HT(1B) receptor gene: no association with cocaine or alcohol abuse or dependence. (11496363)
2001
47
Mean cell volume and gamma-glutamyl transferase are superior to carbohydrate-deficient transferrin and hemoglobin-acetaldehyde adducts in the follow-up of pregnant women with alcohol abuse. (10830762)
2000
48
Effect of apolipoprotein E phenotype on plasma lipids and lipoproteins in alcohol abusers. (9194912)
1997
49
Drinking outcomes of alcohol abusers diagnosed as antisocial personality disorder. (7978086)
1994
50
Intestinal pseudo-obstruction in alcohol abuse: report of two cases. (519478)
1979

Variations for Alcohol Abuse

About this section

Expression for genes affiliated with Alcohol Abuse

About this section
Sources:
2BioGPS, 16Gene Expression Omnibus DataSets
See all sources
Expression patterns in normal tissues for genes affiliated with Alcohol Abuse

Search GEO for disease gene expression data for Alcohol Abuse.

Pathways for genes affiliated with Alcohol Abuse

About this section
Sources:
51PathCards, 56Reactome, 31KEGG, 39NCBI BioSystems Database, 61Thomson Reuters, 52PharmGKB
See all sources

Pathways related to Alcohol Abuse according to GeneCards/GeneDecks:

(show all 11)
idSuper pathways (with members indented)ScoreTop Affiliating Genes
1
Show member pathways
9.3SLC17A5, TF, ABCB7
2
Show member pathways
mitochondrial L-carnitine shuttle pathway39
Saturated fatty acid biosynthesis61
9.2ALDH2, ADH1C
3
Show member pathways
9.2ADH1C, ALDH2
4
Show member pathways
phenylalanine utilization39
noradrenaline and adrenaline degradation39
phenylalanine degradation IV39
9.2ALDH2, ADH1C
5
Show member pathways
glycolysis39
gluconeogenesis39
Glycolysis and Gluconeogenesis39
9.2ALDH2, ADH1C
6
Show member pathways
9.1CYP2E1, ALDH2
7
Show member pathways
Retinol metabolism61
9.1ALDH2, CYP2E1
8
Show member pathways
acetate conversion to acetyl-CoA39
oxidative ethanol degradation III39
ethanol degradation IV39
9.1ALDH2, CYP2E1
9
Show member pathways
8.7ALDH2, ADH1C, CYP2E1
10
Show member pathways
8.7ALDH2, ADH1C, CYP2E1
11
Show member pathways
7.7ABCB7, CYP2E1, GPT, ADH1C, ALDH2

Compounds for genes affiliated with Alcohol Abuse

About this section
Sources:
46Novoseek, 12DrugBank, 52PharmGKB, 30IUPHAR, 25HMDB, 62Tocris Bioscience, 3BitterDB
See all sources

Compounds related to Alcohol Abuse according to GeneCards/GeneDecks:

(show top 50)    (show all 122)
idCompoundScoreTop Affiliating Genes
15-hydroxytryptophol469.8GPT, SLC17A5
2alpha-hydroxybutyrate469.7SLC17A5, GPT
3antipyrine46 1210.6SLC17A5, CYP2E1, TF
4nevirapine46 52 1211.5ABCB7, SLC17A5, GPT
5phosphorus469.5SLC17A5, ABCB7, GPT
6hepaplastin469.5SLC17A5, GPT
7opiate469.5SLC17A5, DRD3, TF
8chlorpromazine30 46 52 1212.5ABCB7, CYP2E1, DRD3
9chloralhydrate469.4ALDH2, CYP2E1
10ribavirin46 52 1211.4TF, SLC17A5, GPT
11vitamin b12469.4SLC17A5, GPT, TF
12nash469.4GPT, CYP2E1, SLC17A5
13sevoflurane52 46 1211.4SLC17A5, GPT, CYP2E1
14uric acid46 2510.4SLC17A5, GPT, ABCB7
15isoniazid46 52 1211.4SLC17A5, GPT, CYP2E1
16isoflurane52 46 1211.3CYP2E1, SLC17A5, GPT
17risperidone46 52 30 62 25 1214.3SLC17A5, DRD3, GPT
18pge1469.3SLC17A5, GPT, TF
19rifampicin46 30 6211.3CYP2E1, SLC17A5, GPT
20ccl446 3010.3SLC17A5, GPT, CYP2E1
21vitamin-e469.3ABCB7, GPT, SLC17A5
22acetaminophen46 3 52 25 1213.2SLC17A5, CYP2E1, GPT
23vinylchloride469.2CYP2E1, ALDH2, SLC17A5
24thyroxine46 2510.1TF, ABCB7, SLC17A5, GPT
25fibrinogen469.1GPT, ABCB7, TF, SLC17A5
26rsai469.1ADH1C, CYP2E1, ALDH2
27ursodeoxycholic acid46 25 1211.1ABCB7, CYP2E1, GPT, SLC17A5
28silymarin469.1ABCB7, CYP2E1, GPT, SLC17A5
29phenobarbital46 30 52 1212.0TF, CYP2E1, SLC17A5, GPT
30cocaine46 1210.0SLC17A5, GPT, TF, DRD3
31clozapine46 30 52 1211.9GPT, DRD3, CYP2E1
32iron46 259.9TF, ABCB7, SLC17A5, GPT
33potassium46 25 1210.9SLC17A5, ABCB7, GPT, DRD3
34nicotine46 30 52 1211.8GPT, SLC17A5, CYP2E1, DRD3
35betacarotene468.8SLC17A5, CYP2E1, TF, ALDH2
36valproic acid46 52 25 1211.7CYP2E1, GPT, SLC17A5
37lactate468.6GPT, SLC17A5, TF, ABCB7, CYP2E1
38sodium46 259.6ABCB7, GPT, SLC17A5, DRD3
39disulfiram46 52 62 1211.6SLC17A5, ALDH2, GPT, CYP2E1
40alpha tocopherol468.5TF, GPT, ALDH2
41glutamine468.4TF, GPT, ALDH2, SLC17A5
42acetaldehyde30 46 2510.3ALDH2, TF, CYP2E1, SLC17A5, ADH1C
43aspartate468.3ALDH2, ABCB7, TF, GPT, SLC17A5
44cholesterol46 30 25 1211.3ABCB7, SLC17A5, TF, ALDH2, GPT
45dopamine46 30 25 1211.3ALDH2, DRD3, TF, CYP2E1
46alanine468.3GPT, ALDH2, SLC17A5, TF, ABCB7
47creatinine467.8SLC17A5, CYP2E1, ALDH2, GPT, TF, ABCB7
48glutamate467.8TF, GPT, DRD3, SLC17A5, ABCB7, ALDH2
49ethanol46 52 25 1210.8SLC17A5, ALDH2, ADH1C, GPT, CYP2E1, ABCB7
50vitamin a46 25 129.7GPT, CYP2E1, TF, SLC17A5, ALDH2, ADH1C

GO Terms for genes affiliated with Alcohol Abuse

About this section
Sources:
17Gene Ontology
See all sources

Cellular components related to Alcohol Abuse according to GeneCards/GeneDecks:

idNameGO IDScoreTop Affiliating Genes
1endocytic vesicleGO:0301399.5DRD3, TF

Biological processes related to Alcohol Abuse according to GeneCards/GeneDecks:

idNameGO IDScoreTop Affiliating Genes
1cellular iron ion homeostasisGO:0068799.6TF, ABCB7
2response to ethanolGO:0454719.4DRD3, CYP2E1
3ethanol oxidationGO:0060699.3ALDH2, ADH1C
4transmembrane transportGO:0550859.0SLC17A5, TF, ABCB7
5xenobiotic metabolic processGO:0068058.7CYP2E1, ADH1C, ALDH2
6small molecule metabolic processGO:0442817.8ALDH2, ADH1C, GPT, CYP2E1, ABCB7

Products for genes affiliated with Alcohol Abuse

About this section
  • Antibodies
  • Proteins
  • Lysates
  • Antibodies

Sources for Alcohol Abuse

About this section
4CDC
14ExPASy
15FMA
23GTR
24HGMD
25HMDB
26ICD10
27ICD10 via Orphanet
28ICD9CM
30IUPHAR
31KEGG
36MeSH
37MESH via Orphanet
38MGI
41NCIt
42NDF-RT
45NINDS
46Novoseek
48OMIM
49OMIM via Orphanet
53PubMed
54QIAGEN
60SNOMED-CT via Orphanet
63UMLS
64UMLS via Orphanet