MCID: ALC004
MIFTS: 57

Alcohol Abuse malady

Summaries for Alcohol Abuse

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8Disease Ontology, 63Wikipedia, 32MalaCards
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Wikipedia:63 Alcohol abuse, as described in the DSM-IV, is a psychiatric diagnosis describing the recurring use of... more...

MalaCards: Alcohol Abuse, also known as ethanol abuse, is related to alcohol dependence and alcoholic hepatitis. An important gene associated with Alcohol Abuse is ABCB7 (ATP-binding cassette, sub-family B (MDR/TAP), member 7), and among its related pathways are Cytochrome P450 - arranged by substrate type and ethanol degradation II. The compounds vitamin a and 5-hydroxytryptophol have been mentioned in the context of this disorder. Affiliated tissues include liver, brain and testes, and related mouse phenotypes are cardiovascular system and growth/size.

Disease Ontology:8 A substance abuse that involves the recurring use of alcoholic beverages despite negative consequences.

Aliases & Classifications for Alcohol Abuse

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8Disease Ontology, 44Novoseek, 60UMLS, 27ICD9CM, 34MeSH, 56SNOMED-CT, 39NCIt
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Aliases & Descriptions:

alcohol abuse 8 44 60
ethanol abuse 8


External Ids:

Disease Ontology8 DOID:1574
ICD9CM27 305.0, 305.00
SNOMED-CT56 304606004, 15167005
MeSH34 D000437
NCIt39 C20701

Related Diseases for Alcohol Abuse

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Sources:
17GeneCards, 18GeneDecks
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Diseases in the Alcohol Abuse family:

Alcohol Sensitivity, Acute

Diseases related to Alcohol Abuse via text searches within MalaCards or GeneCards/GeneDecks gene sharing:

(show top 50)    (show all 203)
idRelated DiseaseScoreTop Affiliating Genes
1alcohol dependence31.5ALDH2, GGT1, SLC6A4, TF, DRD2
2alcoholic hepatitis30.8GGT1, SLC17A5, GPT, RPS27A
3hepatitis30.8SLC17A5, GPT
4substance abuse30.8ALDH2, GGT1, SLC6A4, CYP2E1, TF, DRD3
5cocaine abuse30.6SLC6A4, DRD2
6viral hepatitis30.6GGT1, SLC17A5, ABCB7, GPT, HFE, AKR1A1
7schizophrenia30.6DRD3, COMT
8hepatocellular carcinoma30.6ALDH9A1, ALDH2, GGT1, SLC17A5, ABCB7, GPT
9alcoholic pancreatitis30.5ADH1C, ALDH9A1, ALDH2, CYP2E1, AKR1A1
10pancreatitis30.5ADH1C, ALDH9A1, ALDH2, GGT1, SLC17A5, CYP2E1
11bipolar disorder30.5SLC6A4, CREB1, DRD3, DRD2, COMT
12personality disorder30.4SLC6A4, DRD3, DRD2
13hepatitis c30.4GGT1, SLC17A5, ABCB7, GPT, CYP2E1, HFE
14alcoholic liver cirrhosis30.3ADH1C, ALDH9A1, ALDH2, GGT1, SLC17A5, GPT
15liver cirrhosis30.3ADH1C, ALDH2, GGT1, SLC17A5, ABCB7, GPT
16anxiety disorder30.2SLC6A4
17pathological gambling30.2DRD3, DRD2
18drug dependence30.2SLC6A4, DRD3, DRD2
19cocaine dependence30.2SLC6A4, DRD3, DRD2
20conduct disorder30.2SLC6A4, DRD2, COMT
21eating disorder30.2SLC6A4, GAL, COMT
22psychotic disorder30.2SLC6A4, DRD3, DRD2, COMT
23sickle cell disease30.0TF
24infertility30.0RPS27A
25essential hypertension30.0LCAT, COMT
26antisocial personality disorder30.0SLC6A4, DRD2
27tuberculosis30.0CYP2E1, AKR1A1, CREB1
28hypertension30.0GGT1, SLC6A4, COG2
29panic disorder30.0SLC6A4, COMT
30anorexia nervosa30.0SLC6A4, GAL, COMT
31delusional disorder30.0DRD2
32hepatitis b30.0GGT1, SLC17A5, ABCB7, GPT
33deficiency anemia30.0ABCB7, HFE, TF, LCAT
34acute pancreatitis30.0ADH1C, ALDH2, SLC17A5, ABCB7, GPT
35dementia30.0ALDH2, GAL, RPS27A, COMT
36psoriasis30.0SLC6A4, CREB1
37substance dependence30.0SLC6A4, DRD3, DRD2, COMT
38mood disorder30.0SLC6A4, CREB1, GAL, DRD3, DRD2, COMT
39brain disease30.0SLC17A5, ABCB7, GPT
40lung cancer30.0ADH1C, ALDH9A1, ALDH2, CYP2E1, AKR1A1, CREB1
41breast cancer30.0ADH1C, ALDH9A1, ALDH2, CYP2E1, AKR1A1, GAL
42obesity30.0ALDH2, GGT1, SLC17A5, ABCB7, GPT, CYP2E1
43liver disease10.5
44hepatitis a10.4
45wernicke-korsakoff syndrome10.4
46mental depression10.2
47pneumonia10.2
48alcoholic psychosis10.2
49opioid abuse10.2
50neuronitis10.2

Graphical network of the top 20 diseases related to Alcohol Abuse:



Diseases related to alcohol abuse

Clinical Features for Alcohol Abuse

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Drugs & Therapeutics for Alcohol Abuse

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Sources:
5CenterWatch, 41NIH Clinical Center, 6ClinicalTrials, 60UMLS, 40NDF-RT
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Approved drugs:

Search CenterWatch for Alcohol Abuse

Drug clinical trials:

Search ClinicalTrials for Alcohol Abuse

Search NIH Clinical Center for Alcohol Abuse

Search CenterWatch for Alcohol Abuse

Genetic Tests for Alcohol Abuse

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Anatomical Context for Alcohol Abuse

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32MalaCards
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MalaCards organs/tissues related to Alcohol Abuse:

32
Liver, Brain, Testes, Lung, Heart, Bone, Cortex, Thymus, Breast, Whole blood, Endothelial, Prefrontal cortex, Amygdala

Animal Models for Alcohol Abuse or affiliated genes

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36MGI
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MGI Mouse Phenotypes related to Alcohol Abuse:

36
idDescriptionMGI Source AccessionScoreTop Affiliating Genes
1MP:000538510.1LCAT, DRD2, DRD3, CREB1, CYP2E1, ABCB7
2MP:00053789.8DRD2, DRD3, GAL, TF, CREB1, HFE
3MP:00107689.7AKR1A1, CREB1, TF, DRD3, DRD2, COG2
4MP:00053769.7ADH1C, COMT, LCAT, DRD2, DRD3, GAL
5MP:00053869.6COMT, DRD2, DRD3, GAL, CREB1, HFE

Publications for Alcohol Abuse

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50PubMed
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Articles related to Alcohol Abuse:

(show top 50)    (show all 652)
idTitleAuthorsYear
1
2013 reviewers, the american journal of drug and alcohol abuse. (24359510)
2014
2
Hepatic steatosis in human immunodeficiency virus: a prospective study in patients without viral hepatitis, diabetes, or alcohol abuse. (23059409)
2013
3
Alcohol abuse in cancer patients: a shadow side in the oncological field and research. (24368516)
2013
4
Childhood trauma exposure and alcohol dependence severity in adulthood: mediation by emotional abuse severity and neuroticism. (23278300)
2013
5
Alcohol abuse promotes changes in non-synaptic epileptiform activity with concomitant expression changes in cotransporters and glial cells. (24236060)
2013
6
Associations of the 5-hydroxytryptamine (serotonin) receptor 1B gene (HTR1B) with alcohol, cocaine, and heroin abuse. (23335468)
2013
7
The impact of contingency management on quality of life among cocaine abusers with and without alcohol dependence. (22211346)
2012
8
Surveillance snapshot: Recurrent medical encounters associated with alcohol abuse-related diagnostic codes, active component, U.S. Armed Forces, 2001-2010. (22372755)
2012
9
Comorbid prevalence of alcohol dependence, substance abuse, and external cause of injury in patients with bipolar disorder in a nationwide representative sample in Taiwan. (22788386)
2012
10
Paternal and maternal alcohol abuse and offspring mental distress in the general population: the Nord-TrA,ndelag health study. (22708789)
2012
11
Editorial: Pharmacotherapies for the treatment of alcohol abuse and dependence. (22650966)
2012
12
Zollinger-Ellison syndrome associated with a history of alcohol abuse: coincidence or consequence? (22136832)
2011
13
Sleep electroencephalogram in children with a parental history of alcohol abuse/dependence. (19735444)
2010
14
Quantification of fatty acid ethyl esters (FAEE) and ethyl glucuronide (EtG) in meconium from newborns for detection of alcohol abuse in a maternal health evaluation study. (20145912)
2010
15
Elevated adiponectin serum levels in patients with chronic alcohol abuse rapidly decline during alcohol withdrawal. (19067777)
2009
16
Alcohol abuse and dependence symptoms: a multidimensional model of common and specific etiology. (19769426)
2009
17
Endogenous opioids and addiction to alcohol and other drugs of abuse. (19747123)
2009
18
Depression, suicidality and alcohol abuse among medical and business students. (19873864)
2009
19
Pilot study of interpersonal psychotherapy versus supportive psychotherapy for dysthymic patients with secondary alcohol abuse or dependence. (18552624)
2008
20
Delusional disorder and alcohol abuse in a patient with Wilson's disease. (19061688)
2008
21
The effect of chronic alcohol abuse on the lipids, lipoproteins and apolipoproteins concentrations in the sera]. (18702334)
2008
22
Panic disorder after the end of chronic alcohol abuse: a report of 2 cases. (18787672)
2008
23
Increase of brain endocannabinoid anandamide levels by FAAH inhibition and alcohol abuse behaviours in the rat. (18446329)
2008
24
K-ras mutation, HPV infection and smoking or alcohol abuse positively correlate with esophageal squamous carcinoma. (18592405)
2008
25
Alcohol abuse risk factors and psychiatric disorders in pregnant women with a history of infertility. (18710366)
2008
26
Ingestion of hand sanitizer by a hospitalized patient with a history of alcohol abuse. (19020181)
2008
27
The trouble with alcohol abuse: what are we trying to measure, diagnose, count and prevent? (18554338)
2008
28
Neuropsychological task performance in bipolar spectrum illness: genetics, alcohol abuse, medication and childhood trauma. (18452444)
2008
29
Alcohol drinking patterns and prevalence of alcohol-abuse and dependence in the Israel National Health Survey. (18080649)
2007
30
Postoperative cognitive dysfunction in older patients with a history of alcohol abuse. (17325499)
2007
31
Nurses' experiences of caring for patients with a dual diagnosis of depression and alcohol abuse in a general psychiatric setting. (17957553)
2007
32
Childhood social environment and risk of drug and alcohol abuse in a cohort of Danish men born in 1953. (16443802)
2006
33
Pathways for practice and policy to reduce adolescent alcohol abuse: interpretations from a qualitative study. (16639857)
2006
34
Validity of the one-criterion threshold for an alcohol abuse diagnosis. (16330621)
2005
35
Limitations of DSM-IV operationalizations of alcohol abuse and dependence in a sample of Australian twins. (16354499)
2005
36
Cytochrome P450 2E1 high activity polymorphism in alcohol abuse and end-organ disease. (16425414)
2005
37
Alcohol abuse and occult HBV-a risk factor for hepatocellular carcinoma. (15733529)
2005
38
New developments in prevention and early intervention for alcohol abuse in youths. (15714051)
2005
39
Acute esophageal necrosis caused by alcohol abuse. (16222758)
2005
40
CUGE: a screening instrument for alcohol abuse and dependence in students. (15289205)
2004
41
Collisions and traffic violations of alcohol, cannabis and cocaine abuse clients before and after treatment. (15203356)
2004
42
Discrimination, historical loss and enculturation: culturally specific risk and resiliency factors for alcohol abuse among American Indians. (15376814)
2004
43
History of alcohol abuse reduces response to antipsychotics in people with first episode psychosis. (15273231)
2004
44
Pharmacological treatment of alcohol abuse/dependence with psychiatric comorbidity. (15112938)
2004
45
Paternal alcohol abuse: relationship between child adjustment, parental characteristics, and family functioning. (14617946)
2003
46
Matrix metalloproteinase-9 is elevated in serum of alcohol abusers. (11952806)
2002
47
A functionally deficient DRD2 variant [Ser311Cys] is not linked to alcoholism and substance abuse. (9650635)
1998
48
Alcohol dependence and domestic violence as sequelae of abuse and conduct disorder in childhood. (9827313)
1998
49
The relationship between cannabis use and DSM-IV cannabis abuse and dependence: results from the National Longitudinal Alcohol Epidemiologic Survey. (10689658)
1998
50
Genetic markers of alcohol abuse. (9118563)
1997

Genetic Variations for Alcohol Abuse

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Expression for genes affiliated with Alcohol Abuse

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Sources:
1BioGPS, 15Gene Expression Omnibus DataSets
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Expression patterns in normal tissues for genes affiliated with Alcohol Abuse

Search GEO for disease gene expression data for Alcohol Abuse.

Pathways for genes affiliated with Alcohol Abuse

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Sources:
53Reactome, 37NCBI BioSystems Database, 29KEGG, 12EMD Millipore, 49PharmGKB
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Pathways related to Alcohol Abuse according to GeneCards/GeneDecks:

(show all 13)
idSuper pathways (with members indented)ScoreTop Affiliating Genes
1
Hide members
10.4ADH1C, ALDH2
2
Hide members
10.4ALDH2, CYP2E1
310.4DRD3, DRD2
4
Hide members
10.3ALDH2, ALDH9A1, ADH1C
5
Retinol metabolism
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10.3ALDH9A1, ALDH2, CYP2E1
6
Hide members
10.3CYP2E1, ALDH2, ALDH9A1
7
Hide members
10.3DRD2, DRD3, SLC6A4
810.3AKR1A1, ALDH2, ALDH9A1
9
Hide members
10.3ADH1C, ALDH2, CYP2E1, AKR1A1
10
Hide members
10.2AKR1A1, ALDH2, ALDH9A1, ADH1C
11
Hide members
10.2COMT, DRD2, DRD3, CREB1, SLC6A4
12
Hide members
10.2GPT, ABCB7, GGT1, ALDH2, ALDH9A1, ADH1C
13
Hide members
10.1COMT, AKR1A1, CYP2E1, GGT1, ALDH2, ADH1C

Compounds for genes affiliated with Alcohol Abuse

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Sources:
44Novoseek, 11DrugBank, 24HMDB, 49PharmGKB, 28IUPHAR, 59Tocris Bioscience, 2BitterDB
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Compounds related to Alcohol Abuse according to GeneCards/GeneDecks:

(show top 50)    (show all 237)
idCompoundScoreTop Affiliating Genes
1vitamin a44 11 2412.6ADH1C, ALDH2, CYP2E1, AKR1A1, CREB1, LCAT
25-hydroxytryptophol4410.6AKR1A1, GPT, SLC17A5, ALDH9A1
3nash4410.6AKR1A1, CYP2E1, HFE, GPT, GGT1, SLC17A5
4rsai4410.6AKR1A1, CYP2E1, ALDH9A1, ADH1C, ALDH2, HFE
5methamphetamine44 49 1112.6SLC6A4, CREB1, RPS27A, DRD3, DRD2
6opiate4410.5CREB1, SLC17A5, SLC6A4, TF, GAL, DRD3
7vinylchloride4410.5GGT1, SLC17A5, CYP2E1, ALDH2
8risperidone28 44 49 59 11 2415.5SLC17A5, COMT, DRD2, DRD3, CREB1, GPT
9disulfiram44 59 1112.5ALDH2, SLC17A5, AKR1A1, GPT, GGT1, CYP2E1
10phenobarbital44 28 1112.5TF, AKR1A1, GPT, GGT1, ALDH9A1, CYP2E1
11alpha tocopherol4410.5TF, ALDH2, LCAT, CREB1
12heroin44 49 1112.5COMT, SLC17A5, DRD2, DRD3, SLC6A4
134-hydroxynonenal44 2411.5RPS27A, ALDH2, CYP2E1, LCAT, CREB1, AKR1A1
14bupropion44 49 11 2413.5CYP2E1, DRD3, DRD2, COMT, SLC6A4
15clozapine44 28 49 1113.5SLC6A4, COMT, GPT, DRD2, CYP2E1, DRD3
16choline44 11 2412.4COMT, GAL, TF, ADH1C, ALDH9A1, GGT1
17haloperidol44 28 2 49 1114.4AKR1A1, CREB1, GGT1, SLC6A4, GPT, DRD2
18acetaldehyde44 28 2412.4ADH1C, ALDH9A1, ALDH2, GGT1, SLC17A5, CYP2E1
19nicotine44 49 28 1113.4GGT1, SLC17A5, SLC6A4, GPT, CYP2E1, DRD3
20thyroxine44 2411.4SLC17A5, ABCB7, ALDH9A1, TF, GPT, COG2
21levodopa44 1111.4COMT, RPS27A, DRD2, DRD3, GAL, TF
22estrogen4410.4COG2, SLC6A4, LCAT
23cocaine44 1111.4COMT, DRD2, DRD3, GGT1, SLC17A5, SLC6A4
24epinephrine44 11 2412.4DRD2, SLC17A5, SLC6A4, CREB1, TF, GAL
25valproic acid44 49 11 2413.4COG2, GGT1, SLC17A5, CYP2E1, CREB1, GPT
26formaldehyde44 2411.4CYP2E1, GAL, AKR1A1, RPS27A, ALDH2, ALDH9A1
27ascorbic acid44 2411.4GGT1, DRD2, COMT, TF, HFE, LCAT
28gaba4410.4SLC6A4, AKR1A1, CREB1, ALDH9A1, DRD2, RPS27A
295-hydroxytryptamine4410.4COMT, AKR1A1, CREB1, GAL, DRD2, SLC6A4
30norepinephrine44 11 2412.4GAL, COMT, DRD2, CREB1, DRD3, TF
31n acetylcysteine4410.4RPS27A, AKR1A1, SLC17A5, TF, GGT1, ALDH9A1
32lactate4410.4GGT1, ALDH9A1, CYP2E1, GPT, AKR1A1, CREB1
33bezafibrate44 28 1112.4GGT1, SLC17A5, COG2, LCAT, GPT
34glutamine4410.3ALDH2, LCAT, TF, CREB1, SLC17A5, GPT
35creatinine4410.3COG2, RPS27A, ABCB7, SLC17A5, GPT, CYP2E1
36ethanol44 49 11 2413.3ALDH9A1, ADH1C, ABCB7, ALDH2, GGT1, SLC17A5
37polyacrylamide4410.3SLC17A5, ALDH2, ABCB7, ALDH9A1, LCAT, GAL
38glutamate4410.3SLC6A4, ABCB7, GPT, AKR1A1, GAL, DRD3
39aspartate4410.3GPT, ALDH9A1, RPS27A, TF, AKR1A1, HFE
40dopamine44 28 11 2413.3SLC6A4, ALDH9A1, ALDH2, GGT1, CYP2E1, AKR1A1
41ursodeoxycholic acid44 11 2412.2ABCB7, GPT, SLC17A5, GGT1, CYP2E1
42bromocriptine28 44 1112.2COMT, DRD2, GAL, CREB1, DRD3
43cholesterol44 28 11 2413.2ALDH2, GGT1, SLC17A5, ABCB7, HFE, TF
44testosterone44 59 11 2413.2GGT1, COG2, SLC17A5, SLC6A4, ABCB7, CYP2E1
45lipid4410.2GAL, ABCB7, GPT, CYP2E1, HFE, AKR1A1
46cysteine4410.2CYP2E1, HFE, AKR1A1, CREB1, DRD3, LCAT
47alanine4410.1GGT1, ALDH2, SLC17A5, SLC6A4, COG2, RPS27A
48iron44 2411.1GGT1, SLC17A5, COG2, HFE, ABCB7, GAL
49verapamil44 49 28 11 2414.1SLC6A4, CYP2E1, GPT, SLC17A5, AKR1A1, GGT1
50silymarin449.9GPT, SLC17A5, GGT1, CYP2E1, ABCB7

GO Terms for genes affiliated with Alcohol Abuse

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16Gene Ontology
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Cellular components related to Alcohol Abuse according to GeneCards/GeneDecks:

idNameGO IDScoreTop Affiliating Genes
1basal part of cellGO:04517810.4HFE, TF
2endocytic vesicleGO:03013910.0TF, DRD3, DRD2

Biological processes related to Alcohol Abuse according to GeneCards/GeneDecks:

(show all 19)
idNameGO IDScoreTop Affiliating Genes
1negative regulation of dopamine receptor signaling pathwayGO:06016010.7DRD2, DRD3
2response to histamineGO:03477610.6DRD2, DRD3
3regulation of dopamine uptake involved in synaptic transmissionGO:05158410.6DRD3, DRD2
4regulation of cAMP metabolic processGO:03081410.6DRD2, DRD3
5adenylate cyclase-inhibiting dopamine receptor signaling pathwayGO:00719510.6DRD2, DRD3
6neurotransmitter biosynthetic processGO:04213610.6ALDH9A1, ALDH2, COMT
7dopamine metabolic processGO:04241710.6DRD2, DRD3
8cellular iron ion homeostasisGO:00687910.6ABCB7, HFE, TF
9regulation of dopamine secretionGO:01405910.5DRD2, DRD3
10xenobiotic metabolic processGO:00680510.5COMT, CYP2E1, GGT1, ALDH2, ADH1C
11negative regulation of protein secretionGO:05070910.5DRD2, DRD3
12behavioral response to cocaineGO:04814810.5DRD2, DRD3
13response to drugGO:04249310.4SLC6A4, CYP2E1, CREB1, GAL, DRD3, DRD2
14cellular aldehyde metabolic processGO:00608110.4AKR1A1, ALDH9A1
15ethanol oxidationGO:00606910.4ALDH2, ADH1C
16prepulse inhibitionGO:06013410.4DRD3, DRD2
17small molecule metabolic processGO:04428110.3COMT, LCAT, CYP2E1, GPT, ABCB7, GGT1
18G-protein coupled receptor internalizationGO:00203110.3DRD2, DRD3
19synaptic transmission, dopaminergicGO:00196310.1DRD2, DRD3

Molecular functions related to Alcohol Abuse according to GeneCards/GeneDecks:

idNameGO IDScoreTop Affiliating Genes
1dopamine bindingGO:03524010.4DRD3, DRD2
2dopamine neurotransmitter receptor activity, coupled via Gi/GoGO:00159110.1DRD3, DRD2

Products for genes affiliated with Alcohol Abuse

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  • Antibodies
  • Proteins
  • Lysates
  • Antibodies

Sources for Alcohol Abuse

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3CDC
13ExPASy
14FMA
22GTR
23HGMD
24HMDB
25ICD10
26ICD10 via Orphanet
27ICD9CM
28IUPHAR
29KEGG
34MeSH
35MESH via Orphanet
36MGI
39NCIt
40NDF-RT
43NINDS
44Novoseek
46OMIM
47OMIM via Orphanet
50PubMed
51QIAGEN
57SNOMED-CT via Orphanet
60UMLS
61UMLS via Orphanet