MCID: ALC004
MIFTS: 48

Alcohol Abuse malady

Genetic diseases (common) category

Aliases & Classifications for Alcohol Abuse

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Alcohol Abuse, Aliases & Descriptions:

Name: Alcohol Abuse 30 9 43 60
 
Ethanol Abuse 9


Classifications:

Malacards categories (disease lists): (See all malacards categories)
Global: Genetic diseases (common)


External Ids:

Disease Ontology9 DOID:1574
MeSH33 D000437
SNOMED-CT55 304606004, 15167005
ICD9CM27 305.0, 305.00
NCIt38 C20701

Summaries for Alcohol Abuse

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Wikipedia:63 Alcohol abuse is a psychiatric diagnosis in which there is recurring use of alcohol despite its negative... more...

MalaCards based summary: Alcohol Abuse, also known as ethanol abuse, is related to alcohol dependence and hepatitis. An important gene associated with Alcohol Abuse is ABCB7 (ATP-binding cassette, sub-family B (MDR/TAP), member 7), and among its related pathways are Transport of glucose and other sugars, bile salts and organic acids, metal ions and amine compounds and Fatty acid metabolism. The compounds 5-hydroxytryptophol and alpha-hydroxybutyrate have been mentioned in the context of this disorder. Affiliated tissues include eye, liver and brain, and related mouse phenotypes are growth/size/body and homeostasis/metabolism.

Disease Ontology:9 A substance abuse that involves the recurring use of alcoholic beverages despite negative consequences.

Related Diseases for Alcohol Abuse

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Diseases in the Alcohol Abuse family:

Alcohol Sensitivity, Acute

Diseases related to Alcohol Abuse via text searches within MalaCards or GeneCards Suite gene sharing:

(show top 50)    (show all 129)
idRelated DiseaseScoreTop Affiliating Genes
1alcohol dependence31.2TF, ALDH2
2hepatitis30.7ABCB7, CYP2E1, GPT, SLC17A5
3viral hepatitis30.6ABCB7, GPT, SLC17A5
4liver disease30.6ALDH2, CYP2E1, TF
5alcoholic hepatitis30.4GPT, SLC17A5
6pancreatitis30.2SLC17A5, ALDH2, ADH1C, CYP2E1
7hepatitis b30.2SLC17A5, GPT, ABCB7
8leukopenia30.2SLC17A5, GPT, ABCB7
9alcoholic pancreatitis30.1CYP2E1, ADH1C, ALDH2
10substance abuse30.0TF, CYP2E1, ALDH2, DRD3
11hepatitis c29.9ABCB7, TF, CYP2E1, GPT, SLC17A5
12hepatocellular carcinoma29.6ABCB7, TF, CYP2E1, GPT, ALDH2, SLC17A5
13acute pancreatitis29.4ABCB7, GPT, ADH1C, ALDH2, SLC17A5
14obesity29.3ABCB7, CYP2E1, GPT, ALDH2, SLC17A5
15alcoholic liver cirrhosis29.0SLC17A5, ALDH2, ADH1C, GPT, CYP2E1, TF
16liver cirrhosis29.0ABCB7, TF, CYP2E1, GPT, ADH1C, ALDH2
17schizophrenia10.5
18wernicke-korsakoff syndrome10.4
19bipolar disorder10.4
20brain injury10.4
21traumatic brain injury10.4
22fatty liver disease10.3CYP2E1
23conduct disorder10.3
24personality disorder10.3
25pneumonia10.3
26acute respiratory distress syndrome10.3
27dengue disease10.3SLC17A5, ABCB7
28neuronitis10.2
29eating disorder10.2
30esophagitis10.2
31neuropathy10.2
32pyridoxine deficiency10.2GPT, SLC17A5
33obstructive jaundice10.2SLC17A5, GPT
34acute liver failure10.2SLC17A5, GPT
35choledocholithiasis10.2SLC17A5, GPT
36hellp syndrome10.2GPT, SLC17A5
37scrub typhus10.2SLC17A5, GPT
38hepatic encephalopathy10.2GPT, SLC17A5
39bilirubin metabolic disorder10.2GPT, SLC17A5
40portal hypertension10.2GPT, SLC17A5
41siderosis10.2TF, GPT
42cholangitis10.2GPT, SLC17A5
43splenomegaly10.2SLC17A5, GPT
44non-suppurative otitis media10.1CYP2E1, TF
45autoimmune hepatitis10.1SLC17A5, GPT
46nutritional deficiency disease10.1SLC17A5, CYP2E1, TF
47galactosemia10.1ABCB7, GPT, SLC17A5
48breast cancer10.1
49osteoporosis10.1
50alzheimer disease10.1

Graphical network of the top 20 diseases related to Alcohol Abuse:



Diseases related to alcohol abuse

Symptoms for Alcohol Abuse

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Drugs & Therapeutics for Alcohol Abuse

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Drug clinical trials:

Search ClinicalTrials for Alcohol Abuse

Search NIH Clinical Center for Alcohol Abuse

Genetic Tests for Alcohol Abuse

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Anatomical Context for Alcohol Abuse

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MalaCards organs/tissues related to Alcohol Abuse:

31
Eye, Liver, Brain, Testes, Lung, Heart, Bone, Cortex, Whole blood, Thymus, Colon, Breast, Endothelial, Prefrontal cortex

Animal Models for Alcohol Abuse or affiliated genes

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MGI Mouse Phenotypes related to Alcohol Abuse:

35
idDescriptionMGI Source AccessionScoreTop Affiliating Genes
1MP:00053787.5SLC17A5, DRD3, ALDH2, ADH1C, TF, ABCB7
2MP:00053766.9SLC17A5, ABCB7, TF, CYP2E1, ADH1C, ALDH2
3MP:00107686.7ABCB7, TF, CYP2E1, ADH1C, ALDH2, DRD3

Publications for Alcohol Abuse

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Articles related to Alcohol Abuse:

(show top 50)    (show all 595)
idTitleAuthorsYear
1
Epigenetic signatures of alcohol abuse and hepatitis infection during human hepatocarcinogenesis. (25294808)
2014
2
2013 reviewers, the american journal of drug and alcohol abuse. (24359510)
2014
3
The usefulness of biomarkers of alcohol abuse in hair and serum carbohydrate-deficient transferrin: a case report. (25557913)
2014
4
Alcohol abuse as the strongest risk factor for violent offending in patients with paranoid schizophrenia. (24778102)
2014
5
Examination of genetic variation in GABRA2 with conduct disorder and alcohol abuse and dependence in a longitudinal study. (24687270)
2014
6
Mental Health and Migration: Depression, Alcohol Abuse, and Access to Health Care Among Migrants in Central Asia. (24186359)
2013
7
Cardiovascular morbidity, risk of cancer and alcohol abuse in psoriasis: systematic literature reviews and expert opinion. (23845147)
2013
8
Suicide behavior in parents with alcohol abuse problems and suicide behavior in their offspring-adult offspring and counselor perspectives. (22283687)
2012
9
Patterns of protective factors in an intervention for the prevention of suicide and alcohol abuse with Yup'ik Alaska Native youth. (22931082)
2012
10
Protein biomarkers of alcohol abuse. (22967079)
2012
11
Use of the screening suggested by the National Institute on Alcohol Abuse and Alcoholism and of a newly derived tool for the detection of unhealthy alcohol drinkers among surgical patients. (22152670)
2012
12
A mouse model for adolescent alcohol abuse: stunted growth and effects in brain. (22433022)
2012
13
Adolescent-onset alcohol abuse exacerbates the influence of childhood conduct disorder on late adolescent and early adult antisocial behaviour. (23459369)
2011
14
Central American mothers report family history of depression and alcohol abuse as a predictor of teenage health risk behaviors. (21040088)
2010
15
Parent training with behavioral couples therapy for fathers' alcohol abuse: effects on substance use, parental relationship, parenting, and CPS involvement. (19502478)
2009
16
Strategy for increasing detection rates of drug and alcohol abuse in paediatric emergency departments. (19555445)
2009
17
Suicidal behavior in adolescents with comorbid depression and alcohol abuse. (19461576)
2009
18
Alcohol abuse may lead to depression. (19662693)
2009
19
Correlates of and relationship among lifetime alcohol abuse and alcohol dependence in older community residents in Brazil. (20191090)
2009
20
Biochemical and neurotransmitter changes implicated in alcohol-induced brain damage in chronic or 'binge drinking' alcohol abuse. (19155229)
2009
21
Alcohol abuse in adolescents. (18305075)
2008
22
Pilot study of interpersonal psychotherapy versus supportive psychotherapy for dysthymic patients with secondary alcohol abuse or dependence. (18552624)
2008
23
Association of the functional serotonin transporter promoter polymorphism (5-HTTLPR) with externalizing and internalizing aggressivity and alcohol abuse]. (19331786)
2008
24
Alcohol abuse in sickle cell disease: the Pisces Project. (17882609)
2007
25
Cognitive function in older diabetic subjects with a history of alcohol abuse. (18361128)
2007
26
Increased fibronectin expression in lung in the setting of chronic alcohol abuse. (17374047)
2007
27
Death from seizures induced by chronic alcohol abuse--does it exist? (17383203)
2007
28
Alcohol drinking patterns and prevalence of alcohol-abuse and dependence in the Israel National Health Survey. (18080649)
2007
29
Pneumococcal meningitis in community is frequent after craniocerebral trauma and in alcohol abusers. (18030267)
2007
30
Prevalence and severity of intimate partner violence and associations with family functioning and alcohol abuse in psychiatric inpatients with suicidal intent. (16426084)
2006
31
Alcohol abuse as a risk factor for ARDS]. (17176845)
2006
32
The role played by a former federal government residential school in a First Nation community's alcohol abuse and impaired driving: results of a talking circle. (17131973)
2006
33
Alcohol abuse and risk behavior among adolescents in larger cities in Bosnia and Herzegovina. (15997674)
2005
34
Alcohol abuse screening in primary care. (15702019)
2005
35
Strategies to study human serum transferrin isoforms using integrated liquid chromatography ICPMS, MALDI-TOF, and ESI-Q-TOF detection: application to chronic alcohol abuse. (16131073)
2005
36
Patterns of alcohol consumption in bipolar patients comorbid for alcohol abuse or dependence. (16026491)
2005
37
Should nurses be randomly tested for alcohol abuse? (16116365)
2005
38
CUGE: a screening instrument for alcohol abuse and dependence in students. (15289205)
2004
39
Alcohol abuse among patients with and without HIV infection attending public clinics in western Kenya. (15868970)
2004
40
Depression, alcohol abuse, and generational differences in Mazahua women in a rural Mexican village. (15371136)
2004
41
Alcohol use disorders and mood disorders: a National Institute on Alcohol Abuse and Alcoholism perspective. (15556112)
2004
42
The co-occurrence of DSM-IV alcohol abuse in DSM-IV alcohol dependence: results of the National Epidemiologic Survey on Alcohol and Related Conditions on heterogeneity that differ by population subgroup. (15351767)
2004
43
Synthesis of daidzin analogues as potential agents for alcohol abuse. (12927869)
2003
44
Spectral analyses of sleep EEG in depressed offspring of fathers with or without a positive history of alcohol abuse or dependence: a pilot study. (13679113)
2003
45
Rhabdomyolysis, hepatitis and multiple hematological disorders associated with alcohol abuse: a case report. (12939102)
2002
46
Novel and previously reported single-nucleotide polymorphisms in the human 5-HT(1B) receptor gene: no association with cocaine or alcohol abuse or dependence. (11496363)
2001
47
Mean cell volume and gamma-glutamyl transferase are superior to carbohydrate-deficient transferrin and hemoglobin-acetaldehyde adducts in the follow-up of pregnant women with alcohol abuse. (10830762)
2000
48
Effect of apolipoprotein E phenotype on plasma lipids and lipoproteins in alcohol abusers. (9194912)
1997
49
Drinking outcomes of alcohol abusers diagnosed as antisocial personality disorder. (7978086)
1994
50
Intestinal pseudo-obstruction in alcohol abuse: report of two cases. (519478)
1979

Variations for Alcohol Abuse

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Expression for genes affiliated with Alcohol Abuse

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Search GEO for disease gene expression data for Alcohol Abuse.

Pathways for genes affiliated with Alcohol Abuse

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Pathways related to Alcohol Abuse according to GeneCards Suite gene sharing:

(show all 11)
idSuper pathways (with members indented)ScoreTop Affiliating Genes
1
Show member pathways
9.3SLC17A5, TF, ABCB7
2
Show member pathways
mitochondrial L-carnitine shuttle pathway36
Saturated fatty acid biosynthesis58
9.2ALDH2, ADH1C
3
Show member pathways
9.2ADH1C, ALDH2
4
Show member pathways
phenylalanine utilization36
noradrenaline and adrenaline degradation36
phenylalanine degradation IV36
9.2ALDH2, ADH1C
5
Show member pathways
glycolysis36
gluconeogenesis36
Glycolysis and Gluconeogenesis36
9.2ALDH2, ADH1C
6
Show member pathways
9.1CYP2E1, ALDH2
7
Show member pathways
Retinol metabolism58
9.1ALDH2, CYP2E1
8
Show member pathways
acetate conversion to acetyl-CoA36
oxidative ethanol degradation III36
ethanol degradation IV36
9.1ALDH2, CYP2E1
9
Show member pathways
8.7ALDH2, ADH1C, CYP2E1
10
Show member pathways
8.7ALDH2, ADH1C, CYP2E1
11
Show member pathways
7.7ABCB7, CYP2E1, GPT, ADH1C, ALDH2

Compounds for genes affiliated with Alcohol Abuse

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Compounds related to Alcohol Abuse according to GeneCards Suite gene sharing:

(show top 50)    (show all 122)
idCompoundScoreTop Affiliating Genes
15-hydroxytryptophol439.8GPT, SLC17A5
2alpha-hydroxybutyrate439.7SLC17A5, GPT
3antipyrine43 1210.6SLC17A5, CYP2E1, TF
4nevirapine43 49 1211.5ABCB7, SLC17A5, GPT
5phosphorus439.5SLC17A5, ABCB7, GPT
6hepaplastin439.5SLC17A5, GPT
7opiate439.5SLC17A5, DRD3, TF
8chlorpromazine28 43 49 1212.5ABCB7, CYP2E1, DRD3
9chloralhydrate439.4ALDH2, CYP2E1
10ribavirin43 49 1211.4TF, SLC17A5, GPT
11vitamin b12439.4SLC17A5, GPT, TF
12nash439.4GPT, CYP2E1, SLC17A5
13sevoflurane49 43 1211.4SLC17A5, GPT, CYP2E1
14uric acid43 2410.4SLC17A5, GPT, ABCB7
15isoniazid43 49 1211.4SLC17A5, GPT, CYP2E1
16isoflurane49 43 1211.3CYP2E1, SLC17A5, GPT
17risperidone43 49 28 59 24 1214.3SLC17A5, DRD3, GPT
18pge1439.3SLC17A5, GPT, TF
19rifampicin43 28 5911.3CYP2E1, SLC17A5, GPT
20ccl443 2810.3SLC17A5, GPT, CYP2E1
21vitamin-e439.3ABCB7, GPT, SLC17A5
22acetaminophen43 2 49 24 1213.2SLC17A5, CYP2E1, GPT
23vinylchloride439.2CYP2E1, ALDH2, SLC17A5
24thyroxine43 2410.1TF, ABCB7, SLC17A5, GPT
25fibrinogen439.1GPT, ABCB7, TF, SLC17A5
26rsai439.1ADH1C, CYP2E1, ALDH2
27ursodeoxycholic acid43 24 1211.1ABCB7, CYP2E1, GPT, SLC17A5
28silymarin439.1ABCB7, CYP2E1, GPT, SLC17A5
29phenobarbital43 28 49 1212.0TF, CYP2E1, SLC17A5, GPT
30cocaine43 1210.0SLC17A5, GPT, TF, DRD3
31clozapine43 28 49 1211.9GPT, DRD3, CYP2E1
32iron43 249.9TF, ABCB7, SLC17A5, GPT
33potassium43 24 1210.9SLC17A5, ABCB7, GPT, DRD3
34nicotine43 28 49 1211.8GPT, SLC17A5, CYP2E1, DRD3
35betacarotene438.8SLC17A5, CYP2E1, TF, ALDH2
36valproic acid43 49 24 1211.7CYP2E1, GPT, SLC17A5
37lactate438.6GPT, SLC17A5, TF, ABCB7, CYP2E1
38sodium43 249.6ABCB7, GPT, SLC17A5, DRD3
39disulfiram43 49 59 1211.6SLC17A5, ALDH2, GPT, CYP2E1
40alpha tocopherol438.5TF, GPT, ALDH2
41glutamine438.4TF, GPT, ALDH2, SLC17A5
42acetaldehyde28 43 2410.3ALDH2, TF, CYP2E1, SLC17A5, ADH1C
43aspartate438.3ALDH2, ABCB7, TF, GPT, SLC17A5
44cholesterol43 28 24 1211.3ABCB7, SLC17A5, TF, ALDH2, GPT
45dopamine43 28 24 1211.3ALDH2, DRD3, TF, CYP2E1
46alanine438.3GPT, ALDH2, SLC17A5, TF, ABCB7
47creatinine437.8SLC17A5, CYP2E1, ALDH2, GPT, TF, ABCB7
48glutamate437.8TF, GPT, DRD3, SLC17A5, ABCB7, ALDH2
49ethanol43 49 24 1210.8SLC17A5, ALDH2, ADH1C, GPT, CYP2E1, ABCB7
50vitamin a43 24 129.7GPT, CYP2E1, TF, SLC17A5, ALDH2, ADH1C

GO Terms for genes affiliated with Alcohol Abuse

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Cellular components related to Alcohol Abuse according to GeneCards Suite gene sharing:

idNameGO IDScoreTop Affiliating Genes
1endocytic vesicleGO:00301399.5DRD3, TF

Biological processes related to Alcohol Abuse according to GeneCards Suite gene sharing:

idNameGO IDScoreTop Affiliating Genes
1cellular iron ion homeostasisGO:00068799.6TF, ABCB7
2response to ethanolGO:00454719.4DRD3, CYP2E1
3ethanol oxidationGO:00060699.3ALDH2, ADH1C
4transmembrane transportGO:00550859.0SLC17A5, TF, ABCB7
5xenobiotic metabolic processGO:00068058.7CYP2E1, ADH1C, ALDH2
6small molecule metabolic processGO:00442817.8ALDH2, ADH1C, GPT, CYP2E1, ABCB7

Products for genes affiliated with Alcohol Abuse

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Sources for Alcohol Abuse

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3CDC
13ExPASy
14FMA
22GTR
23HGMD
24HMDB
25ICD10
26ICD10 via Orphanet
27ICD9CM
28IUPHAR
29KEGG
33MeSH
34MESH via Orphanet
35MGI
38NCIt
39NDF-RT
42NINDS
43Novoseek
45OMIM
46OMIM via Orphanet
50PubMed
51QIAGEN
56SNOMED-CT via Orphanet
60UMLS
61UMLS via Orphanet