MCID: ALC004
MIFTS: 59

Alcohol Abuse malady

Categories: Mental diseases, Genetic diseases, Rare diseases

Aliases & Classifications for Alcohol Abuse

Aliases & Descriptions for Alcohol Abuse:

Name: Alcohol Abuse 38 12 52 14 69
Alcohol-Related Disorders 42 69
Alcoholic Intoxication, Chronic 69
Ethanol Abuse 12
Alcoholism 42

Classifications:



External Ids:

Disease Ontology 12 DOID:1574
ICD10 33 F10.1
ICD9CM 35 305.0 305.00
NCIt 47 C20701
SNOMED-CT 64 15167005 304606004
UMLS 69 C0085762

Summaries for Alcohol Abuse

Disease Ontology : 12 A substance abuse that involves the recurring use of alcoholic beverages despite negative consequences.

MalaCards based summary : Alcohol Abuse, also known as alcohol-related disorders, is related to personality disorder and schizophrenia, and has symptoms including hangover from any alcohol or other drugs substance and hangover from alcohol. An important gene associated with Alcohol Abuse is CYP2E1 (Cytochrome P450 Family 2 Subfamily E Member 1), and among its related pathways/superpathways are Porphyrin and chlorophyll metabolism and Monoamine GPCRs. The drugs Acamprosate and Ethanol have been mentioned in the context of this disorder. Affiliated tissues include liver, brain and testes, and related phenotypes are Decreased melanin production and homeostasis/metabolism

Wikipedia : 71 Alcohol abuse is a previous psychiatric diagnosis in which there is recurring harmful use of ethanol... more...

Related Diseases for Alcohol Abuse

Diseases in the Alcohol Abuse family:

Alcohol Sensitivity, Acute

Diseases related to Alcohol Abuse via text searches within MalaCards or GeneCards Suite gene sharing:

(show top 50) (show all 166)
id Related Disease Score Top Affiliating Genes
1 personality disorder 29.0 ALDH2 BDNF CNR1 DRD2 DRD3 DRD4
2 schizophrenia 28.7 ANKK1 BDNF CNR1 DRD2 DRD3 DRD4
3 fetal alcohol syndrome 12.3
4 alcohol dependence 11.2
5 wernicke-korsakoff syndrome 11.2
6 lipomatosis, multiple symmetric 10.9
7 nuchal bleb, familial 10.9
8 cerebellar degeneration 10.9
9 beriberi 10.9
10 megalocytic interstitial nephritis 10.9
11 nonalcoholic steatohepatitis 10.9
12 atrial fibrillation and stroke 10.9
13 cerebral beriberi 10.9
14 osteonecrosis 10.9
15 birth defects 10.9
16 hypersomnia 10.9
17 korsakoff's amnesic syndrome 10.9
18 hyperchylomicronemia, late-onset 10.9
19 tremor 10.9
20 ebstein anomaly 10.3 GGT1 SLC17A5
21 gastric neuroendocrine tumor type 1 10.3 GPT SLC17A5
22 ringed hair 10.3 GGT1 GPT
23 female infertility of uterine origin 10.3 GPT SLC17A5 TF
24 retinal arterial macroaneurysm with supravalvular pulmonic stenosis 10.2 GPT SLC17A5 TF
25 radiation induced cancer 10.2 GPT SLC17A5
26 paranasal sinus sarcoma 10.2 GGT1 GPT SLC17A5
27 not otherwise specified 3-mga-uria type 10.2 CYP2E1 GPT SLC17A5
28 colorectal adenocarcinoma 10.2 DRD2 DRD4 SLC6A4
29 noninfectious dermatoses of eyelid 10.2 ABCB7 GGT1 GPT SLC17A5
30 auditory neuropathy, autosomal dominant, 1 10.2 DRD2 GPT TF
31 amelogenesis imperfecta 10.2 CYP2E1 GPT SLC17A5
32 postencephalitic parkinson disease 10.1 BDNF DRD2 SLC6A4
33 hepatitis 10.1
34 sphenoorbital meningioma 10.1 DRD2 DRD3 DRD4
35 lethal hydranencephaly-diaphragmatic hernia syndrome 10.1 AKR1A1 CYP2E1
36 teratoma with malignant transformation 10.1 BDNF DRD2 DRD3
37 ornithosis 10.1 DRD2 PRL SLC6A4
38 anal fistula 10.1 ALDH2 CYP2E1 SLC17A5 TF
39 rectosigmoid junction neoplasm 10.1 CNR1 DRD2 DRD4
40 nephrogenic adenoma of the urethra 10.1 DRD2 PRL SLC6A4
41 neonatal period electroclinical syndrome 10.1 AKR1A1 ALDH9A1 BDNF
42 c8 deficiency, type ii 10.1 DRD2 DRD3 DRD4 FAAH
43 carotid stenosis 10.1 ALDH2 DRD2 DRD4 SLC6A4
44 chronic eosinophilic pneumonia 10.0 BDNF PRL SLC6A4
45 schizoid personality disorder 10.0 DRD3 SLC6A4
46 pyromania 10.0 DRD2 DRD3 DRD4 SLC6A4
47 liver disease 10.0
48 lymphoid leukemia 10.0 ABCB7 CYP2E1 GGT1 GPT SLC17A5 TF
49 cholesteatoma 10.0 BDNF CNR1 DRD2 SLC6A4
50 hereditary multiple exostoses 10.0 BDNF CNR1 DRD2 SLC6A4

Comorbidity relations with Alcohol Abuse via Phenotypic Disease Network (PDN): (show all 19)


Active Peptic Ulcer Disease Acute Cystitis
Acute Pancreatitis Alcohol-Induced Mental Disorder
Alcoholic Cardiomyopathy Alcoholic Gastritis
Alcoholic Hepatitis Alcoholic Liver Cirrhosis
Alcoholic Neuropathy Cocaine Abuse
Deficiency Anemia Familial Atrial Fibrillation
Fatty Liver Disease Hepatic Encephalopathy
Hypertension, Essential Pancreatitis, Hereditary
Protein-Energy Malnutrition Respiratory Failure
Schizophreniform Disorder

Graphical network of the top 20 diseases related to Alcohol Abuse:



Diseases related to Alcohol Abuse

Symptoms & Phenotypes for Alcohol Abuse

UMLS symptoms related to Alcohol Abuse:


hangover from any alcohol or other drugs substance, hangover from alcohol

GenomeRNAi Phenotypes related to Alcohol Abuse according to GeneCards Suite gene sharing:

26
id Description GenomeRNAi Source Accession Score Top Affiliating Genes
1 Decreased melanin production GR00056-A 8.8 ALDH9A1 SLC17A5 UROD

MGI Mouse Phenotypes related to Alcohol Abuse:

44
id Description MGI Source Accession Score Top Affiliating Genes
1 homeostasis/metabolism MP:0005376 10.16 ABCB7 AKR1A1 ALDH2 BDNF CNR1 CYP2E1
2 behavior/neurological MP:0005386 10.15 ALDH2 BDNF CNR1 CYP2E1 DRD2 DRD3
3 growth/size/body region MP:0005378 10.06 ABCB7 AKR1A1 ALDH2 BDNF CNR1 DRD2
4 integument MP:0010771 9.81 ALDH2 ALDH9A1 BDNF CNR1 DRD2 FAAH
5 mortality/aging MP:0010768 9.8 FAAH GGT1 SLC17A5 SLC6A4 TF UROD
6 nervous system MP:0003631 9.36 BDNF CNR1 DRD2 ABCB7 ALDH2 DRD3

Drugs & Therapeutics for Alcohol Abuse

Drugs for Alcohol Abuse (from DrugBank, HMDB, Dgidb, PharmGKB, IUPHAR, NovoSeek, BitterDB):

(show top 50) (show all 525)
id Name Status Phase Clinical Trials Cas Number PubChem Id
1
Acamprosate Approved, Investigational Phase 4,Phase 3,Phase 2,Phase 1 77337-76-9 71158
2
Ethanol Approved Phase 4,Phase 2,Phase 3,Phase 1,Early Phase 1 64-17-5 702
3
Topiramate Approved Phase 4,Phase 3,Phase 2,Phase 1,Early Phase 1 97240-79-4 5284627
4
Disulfiram Approved Phase 4,Phase 2,Phase 1 97-77-8 3117
5
Naltrexone Approved, Investigational, Vet_approved Phase 4,Phase 3,Phase 2,Phase 1,Early Phase 1 16590-41-3 5360515
6
Bupropion Approved Phase 4,Phase 3,Phase 2,Phase 1 34841-39-9, 34911-55-2 444
7
Dopamine Approved Phase 4,Phase 3,Phase 2,Phase 1,Early Phase 1 51-61-6, 62-31-7 681
8
Fluoxetine Approved, Vet_approved Phase 4,Phase 3,Phase 2 54910-89-3 3386
9
Lamotrigine Approved, Investigational Phase 4,Phase 3 84057-84-1 3878
10
Losartan Approved Phase 4 114798-26-4 3961
11
Acetaminophen Approved Phase 4 103-90-2 1983
12
Clonidine Approved Phase 4 4205-90-7 2803
13
Ropivacaine Approved Phase 4 84057-95-4 71273 175805
14
Sufentanil Approved, Investigational Phase 4 56030-54-7 41693
15
Tramadol Approved, Investigational Phase 4 27203-92-5 33741
16
Guaifenesin Approved, Vet_approved Phase 4,Phase 2,Phase 3,Phase 1 93-14-1 3516
17
Methadone Approved Phase 4,Phase 2,Phase 3,Phase 1 76-99-3 4095
18
Varenicline Approved, Investigational Phase 4,Phase 2,Phase 3,Phase 1,Early Phase 1 249296-44-4 5310966
19
Prazosin Approved Phase 4,Phase 3,Phase 2,Phase 1,Early Phase 1 19216-56-9 4893
20
Nicotine Approved Phase 4,Phase 2,Phase 3,Phase 1,Early Phase 1 54-11-5 942 89594
21
Baclofen Approved Phase 4,Phase 3,Phase 2,Phase 1,Early Phase 1 1134-47-0 2284
22
Histamine Approved, Investigational Phase 4,Phase 2 75614-87-8, 51-45-6 774
23
Ribavirin Approved Phase 4,Phase 2,Phase 1 36791-04-5 37542
24
Pentoxifylline Approved, Investigational Phase 4,Phase 3,Phase 2,Phase 1 6493-05-6 4740
25
Buprenorphine Approved, Illicit, Investigational, Vet_approved Phase 4,Phase 3,Phase 2,Phase 1 52485-79-7 40400 644073
26
Valproic Acid Approved, Investigational Phase 4,Phase 2,Phase 3,Phase 1 99-66-1 3121
27
Amphetamine Approved, Illicit Phase 4,Phase 2,Phase 3 300-62-9 5826 3007
28
Cocaine Approved, Illicit Phase 4,Phase 3,Phase 2,Phase 1,Early Phase 1 50-36-2 5760 446220
29
Gabapentin Approved, Investigational Phase 4,Phase 2,Phase 3 60142-96-3 3446
30
Lenograstim Approved Phase 4,Phase 3 135968-09-1
31
Ondansetron Approved Phase 4,Phase 3,Phase 2,Phase 1 99614-02-5 4595
32
Midazolam Approved, Illicit Phase 4 59467-70-8 4192
33
Propofol Approved, Investigational, Vet_approved Phase 4,Phase 1 2078-54-8 4943
34
Benzocaine Approved Phase 4,Phase 3,Phase 2,Phase 1 1994-09-7, 94-09-7 2337
35
Sertraline Approved Phase 4,Phase 2,Phase 1 79617-96-2 68617
36
Chlorzoxazone Approved Phase 4 95-25-0 2733
37
Dutasteride Approved, Investigational Phase 4 164656-23-9 152945 6918296
38
Icodextrin Approved, Investigational Phase 4 337376-15-5
39
Zonisamide Approved, Investigational Phase 4,Phase 3,Phase 2,Phase 1 68291-97-4 5734
40 Piracetam Approved Phase 4,Phase 3,Phase 2 7491-74-9
41
Aripiprazole Approved, Investigational Phase 4,Phase 3,Phase 2 129722-12-9 60795
42
Carbamazepine Approved, Investigational Phase 4 298-46-4 2554
43
Lorazepam Approved Phase 4,Phase 2 846-49-1 3958
44
Risperidone Approved, Investigational Phase 4,Phase 2 106266-06-2 5073
45
Paroxetine Approved, Investigational Phase 4,Phase 3 61869-08-7 43815
46
Citalopram Approved Phase 4,Phase 2,Phase 1 59729-33-8 2771
47
Memantine Approved, Investigational Phase 4,Phase 3,Phase 2 19982-08-2 4054
48
Oxazepam Approved Phase 4 604-75-1 4616
49
Sodium oxybate Approved Phase 4 502-85-2 5360545
50
Methylphenidate Approved, Investigational Phase 4,Early Phase 1 113-45-1 4158

Interventional clinical trials:

(show top 50) (show all 1544)
id Name Status NCT ID Phase
1 Safety of Acamprosate for Alcohol Dependence in the Elderly: An Open-Label Study (SAFADIE) Unknown status NCT00655967 Phase 4
2 Topiramate for Hospitalized Patients With Alcoholism: a 12-week Study Unknown status NCT01135602 Phase 4
3 Antabuse in Severe Alcoholism: an Open Controlled Study Unknown status NCT00431262 Phase 4
4 Trial for the Treatment of Alcohol Dependence Unknown status NCT00120601 Phase 4
5 Acamprosate vs. Placebo in Bipolar Alcoholics Unknown status NCT00466661 Phase 4
6 Effect of Probiotics on Gut-Liver Axis of Alcoholic Hepatitis Unknown status NCT02335632 Phase 4
7 Fluoxetine and Bupropion to Treat Patients With Depression and Alcoholism Unknown status NCT00449007 Phase 4
8 Treatment of Alcohol Dependence and Comorbid Bipolar Disorder Unknown status NCT01015586 Phase 4
9 Prevention of Decompensation in Liver Cirrhosis Unknown status NCT00239096 Phase 4
10 Efficacy and Safety of S-adenosyl-l-methionine in Treatment of Alcoholic Hepatitis With Cholestasis Unknown status NCT02024295 Phase 4
11 Epidural Analgesia for Pancreatitis (Epipan Study) Unknown status NCT02126332 Phase 4
12 Smoking Cessation Treatment for Methadone Maintenance Patients Unknown status NCT01027754 Phase 4
13 Using Repetitive Transcranial Magnetic Stimulation (rTMS) for the Treatment of Bipolar Depression Unknown status NCT01583023 Phase 4
14 Hepatic Function in Alcoholics Following 5 Days of Acetaminophen Dosing Completed NCT00427206 Phase 4
15 Hepatic Function During and Following Three Days of Acetaminophen Dosing in Alcoholics Completed NCT00402571 Phase 4
16 Substance Dependent Teens - Impact of Treating Depression Study 1 - 1 Completed NCT00061113 Phase 4
17 Naltrexone Treatment of Alcohol Abuse in Schizophrenia Completed NCT00145847 Phase 4
18 Magnesium After Alcohol Withdrawal Treatment Completed NCT00325299 Phase 4
19 Adolescent Family-Based Alcohol Prevention Completed NCT00858065 Phase 4
20 The Whole Day First Grade Program Completed NCT00257088 Phase 4
21 ALK21-018: Effects of Medisorb® Naltrexone (VIVITROL®) on Alcohol Craving in Treatment-seeking, Alcohol-dependent Adults Completed NCT00511836 Phase 4
22 Naltrexone Treatment for Alcoholic Women Completed NCT00000448 Phase 4
23 A Randomized Clinical Trial of Alcohol Care Management Completed NCT00419315 Phase 4
24 Prazosin Alcohol Dependence IVR Study Completed NCT00167687 Phase 4
25 Integrative Therapy in Alcoholism Completed NCT00159107 Phase 4
26 Naltrexone for Early Problem Drinkers Completed NCT00000455 Phase 4
27 Naltrexone, Craving, and Drinking Completed NCT00006203 Phase 4
28 Smoking Cessation in Alcoholism Treatment Completed NCT00000454 Phase 4
29 Sertraline Pharmacotherapy for Alcoholism Subtypes Completed NCT00368550 Phase 4
30 Behavioral/Drug Therapy for Alcohol-Nicotine Dependence (Naltrexone/Nicotine Patch) Completed NCT00000447 Phase 4
31 Efficacy of Quetiapine in the Treatment of Patients With Schizophrenia and a Comorbid Substance Use Disorder Completed NCT00156715 Phase 4
32 Treatment of Patients Suffering of Alcohol Dependence and Impaired Liver Function With Selincro® As-needed Use Completed NCT02197598 Phase 4
33 Citicoline for Alcohol Dependence Completed NCT02074735 Phase 4
34 Placebo-Controlled Cross Over Trial of Chlorzoxazone Intake Completed NCT01342341 Phase 4
35 Varenicline in Drug Treatment Completed NCT01286584 Phase 4
36 Dutasteride for the Reduction of Alcohol Use in Male Drinkers Completed NCT01262287 Phase 4
37 Identifying Multiple Mechanisms of Change in Alcoholism Treatment Completed NCT01168960 Phase 4
38 Baclofen as Add-On to Standard Treatment of Alcohol- Dependent Patients Completed NCT01002105 Phase 4
39 Genetic and Brain Mechanisms of Naltrexone's Treatment Efficacy for Alcoholism Completed NCT00920829 Phase 4
40 Alcohol Detoxification in Primary Care Treatment (ADEPT) Completed NCT00855699 Phase 4
41 Pharmacogenetic Response to Naltrexone For Alcohol Dependence Completed NCT00831272 Phase 4
42 Understanding Treatment Response With Naltrexone Among White Alcoholics Completed NCT00817089 Phase 4
43 High Dose Vitamin B1 to Reduce Abusive Alcohol Use Completed NCT00680121 Phase 4
44 Acamprosate: Genes Associated With Response Completed NCT00662571 Phase 4
45 Extended-release Naltrexone for Alcohol Dependence in Primary Care Completed NCT00620750 Phase 4
46 Zonisamide vs. Placebo in the Treatment of Alcohol Dependence Completed NCT00595556 Phase 4
47 Comparative Trial Of Disulfiram, Naltrexone And Acamprosate In The Treatment Of Alcohol Dependence Completed NCT00435435 Phase 4
48 Study of Campral (Acamprosate) for Alcohol Dependence in a Family Medicine Clinic Completed NCT00381043 Phase 4
49 Effectiveness of Naltrexone Versus Placebo to Reduce Craving for Alcohol With Evaluation of Genetic Variability. Completed NCT00366626 Phase 4
50 The Effects of Topiramate on Alcohol Use in Alcohol Dependent Subjects Completed NCT00329407 Phase 4

Search NIH Clinical Center for Alcohol Abuse

Inferred drug relations via UMLS 69 / NDF-RT 48 :


Cochrane evidence based reviews: alcoholism

Genetic Tests for Alcohol Abuse

Anatomical Context for Alcohol Abuse

MalaCards organs/tissues related to Alcohol Abuse:

39
Liver, Brain, Testes, Lung, Bone, Heart, Cortex

Publications for Alcohol Abuse

Articles related to Alcohol Abuse:

(show top 50) (show all 673)
id Title Authors Year
1
Chronic Alcohol Abuse Leads to Low Bone Mass with No General Loss of Bone Structure or Bone Mechanical Strength(). ( 27864963 )
2017
2
Genetic divergence in the transcriptional engram of chronic alcohol abuse: A laser-capture RNA-seq study of the mouse mesocorticolimbic system. ( 27894806 )
2017
3
Contextual Factors Related to Alcohol Abuse Among Intimate Partner Violence Offenders. ( 27759488 )
2017
4
Alcohol Abuse and Cardiac Disease. ( 28057245 )
2017
5
Correlates of depression in self-neglecting older adults: A cross-sectional study examining the role of alcohol abuse and pain in increasing vulnerability. ( 26716386 )
2016
6
Randomized Trial of Motivational Interviewing Plus Feedback for Soldiers With Untreated Alcohol Abuse. ( 27736113 )
2016
7
The influences of parental divorce and maternal-versus-paternal alcohol abuse on offspring lifetime suicide attempt. ( 27538533 )
2016
8
Glucocorticoid Receptor (NR3C1) Gene Polymorphism Moderate Intervention Effects on the Developmental Trajectory of African-American Adolescent Alcohol Abuse. ( 27817096 )
2016
9
Physiological processes underlying organ injury in alcohol abuse. ( 27436613 )
2016
10
Erythromelalgia-like presentation of chronic acquired demyelinating polyneuropathy in a setting of past alcohol abuse. ( 26804376 )
2016
11
Maternal drug or alcohol abuse is associated with decreased head size from mid-pregnancy to childhood. ( 27037638 )
2016
12
Recent Advances in Nicotinic Receptor Signaling in Alcohol Abuse and Alcoholism. ( 26810002 )
2016
13
Alcohol abuse and smoking alter inflammatory mediator production by pulmonary and systemic immune cells. ( 26747782 )
2016
14
Improvements in Empathy and Cognitive Flexibility after Court-Mandated Intervention Program in Intimate Partner Violence Perpetrators: The Role of Alcohol Abuse. ( 27043602 )
2016
15
Lights! Camera! Action Projects! Engaging Psychopharmacology Students in Service-based Action Projects Focusing on Student Alcohol Abuse. ( 27385923 )
2016
16
Are therapeutic vaccines an answer to the global problem of drug and alcohol abuse? ( 27721531 )
2016
17
Alcohol abuse increases the risk of HIV infection and diminishes health status of clients attending HIV testing services in Vietnam. ( 26879232 )
2016
18
Iudicium: An Educational Intervention for addressing Risk Perception of Alcohol Abuse in Adolescents. ( 26990389 )
2016
19
Pathological Gambling and Associated Drug and Alcohol Abuse, Emotion Regulation, and Anxious-Depressive Symptomatology. ( 27348555 )
2016
20
Recognition of depression, anxiety, and alcohol abuse in a Chinese rural sample: a cross-sectional study. ( 27053369 )
2016
21
When a liver transplant recipient goes back to alcohol abuse: Should we be more selective? ( 27239105 )
2016
22
Club drugs and alcohol abuse predicted dropout and poor adherence among methadone maintenance treatment patients in Guangzhou, China. ( 27903083 )
2016
23
11I^-hydroxysteroid dehydrogenase inhibition as a new potential therapeutic target for alcohol abuse. ( 26978742 )
2016
24
Alcohol abuse recovery through the lens of Manitoban First Nations and Aboriginal women: A qualitative study. ( 27115828 )
2016
25
Alcohol abuse and other factors associated with risky sexual behaviors among adolescent students from the poorest areas in Costa Rica. ( 27572491 )
2016
26
Factors associated with alcohol abuse and dependence among public transport workers in the metropolitan region of Belo Horizonte. ( 27001551 )
2016
27
Cognitive Decline and Recovery in Alcohol Abuse. ( 27460131 )
2016
28
Chronic Hepatitis C and Alcohol Abuse: The Single Center Experience of Novi Sad - Serbia. ( 27457344 )
2016
29
Couples living with and around alcohol abuse: A study of a farmworker community in the Cape Winelands, South Africa. ( 27043369 )
2016
30
Oxytocin receptor gene variation rs53576 and alcohol abuse in a longitudinal population representative study. ( 27716573 )
2016
31
Small opportunities are often the beginning of great enterprises: The role of work engagement in support of people through the recovery process and in preventing relapse in drug and alcohol abuse. ( 27689594 )
2016
32
Informal Control by Family and Risk Markers for Alcohol Abuse/Dependence in Seoul. ( 27161846 )
2016
33
Workplace Discrimination Is Associated With Alcohol Abuse Among Ethnically Diverse Hospital Staff. ( 27034406 )
2016
34
Negative and interactive effects of sex, aging, and alcohol abuse on gray matter morphometry. ( 26947584 )
2016
35
Alcohol abuse after traumatic brain injury: Experimental and clinical evidence. ( 26814960 )
2016
36
Drinking to ease the burden: a cross-sectional study on trauma, alcohol abuse and psychopathology in a post-conflict context. ( 27342048 )
2016
37
Alcohol abuse and involvement in traffic accidents in the Brazilian population, 2013. ( 27925118 )
2016
38
Postoperative delirium in patients with history of alcohol abuse. ( 27641821 )
2016
39
Chronic alcohol abuse. ( 27903033 )
2016
40
Burnout and Alcohol Abuse/Dependence Among U.S. Medical Students. ( 26934693 )
2016
41
Acute oesophageal necrosis in a young man with cocaine and alcohol abuse. ( 27881583 )
2016
42
Bioinformatic Analysis of DNA Methylation in Neural Progenitor Cell Models of Alcohol Abuse. ( 27774408 )
2016
43
Family history of mental illness or alcohol abuse and the irritable bowel syndrome. ( 25582802 )
2015
44
Alcohol abuse and alcoholic liver cirrhosis leading to spontaneous muscle hematoma: an event fraught with danger. ( 25969676 )
2015
45
Transcriptome organization for chronic alcohol abuse in human brain. ( 25450227 )
2015
46
Wernicke's encephalopathy in two different clinical settings: one after whipple surgery and the other due to alcohol abuse. ( 25716503 )
2015
47
Alcohol Abuse Management in Primary Care: An e-Learning Course. ( 25599269 )
2015
48
Synthesis of aza and carbocyclic I^-carbolines for the treatment of alcohol abuse. Regiospecific solution to the problem of 3,6-disubstituted I^- and aza-I^-carboline specificity. ( 26349488 )
2015
49
Preventing Alcohol Abuse Through Social Networking Sites: A First Assessment of a Two-Year Ecological Approach. ( 26681577 )
2015
50
Post-Acute Coronary Syndrome Alcohol Abuse: Prospective Evaluation in the ERICO Study. ( 26131701 )
2015

Variations for Alcohol Abuse

Expression for Alcohol Abuse

LifeMap Discovery
Genes differentially expressed in tissues of Alcohol Abuse patients vs. healthy controls: 35
id Gene Description Tissue Up/Dn Fold Change (log2) P value
1 ADAMTS18 ADAM metallopeptidase with thrombospondin type 1 motif, 18 Brain - 3.66 0.005
Search GEO for disease gene expression data for Alcohol Abuse.

Pathways for Alcohol Abuse

Pathways related to Alcohol Abuse according to GeneCards Suite gene sharing:

id Super pathways Score Top Affiliating Genes
1
Show member pathways
11.89 AKR1A1 ALDH2 ALDH9A1 UROD
2
Show member pathways
11.64 DRD2 DRD3 DRD4
4 11.55 CNR1 DRD3 DRD4
5
Show member pathways
11.51 DRD2 DRD3 DRD4
6
Show member pathways
11.17 AKR1A1 ALDH2 ALDH9A1 CYP2E1
7
Show member pathways
10.43 ALDH2 CYP2E1

GO Terms for Alcohol Abuse

Cellular components related to Alcohol Abuse according to GeneCards Suite gene sharing:

id Name GO ID Score Top Affiliating Genes
1 endocytic vesicle GO:0030139 8.8 DRD2 DRD3 TF

Biological processes related to Alcohol Abuse according to GeneCards Suite gene sharing:

(show all 32)
id Name GO ID Score Top Affiliating Genes
1 response to drug GO:0042493 9.98 CYP2E1 DRD2 DRD3 PRL SLC6A4
2 response to nutrient GO:0007584 9.79 CNR1 PRL SLC6A4
3 social behavior GO:0035176 9.77 DRD3 DRD4 SLC6A4
4 response to cocaine GO:0042220 9.75 CNR1 DRD2 DRD3
5 negative regulation of blood pressure GO:0045776 9.7 CNR1 DRD2 DRD3
6 response to morphine GO:0043278 9.69 CNR1 DRD2 DRD3
7 negative regulation of adenylate cyclase activity GO:0007194 9.67 DRD2 DRD3 DRD4
8 synaptic transmission, dopaminergic GO:0001963 9.65 DRD2 DRD3
9 behavioral response to ethanol GO:0048149 9.65 DRD2 DRD4
10 neurotransmitter biosynthetic process GO:0042136 9.65 ALDH9A1 SLC6A4
11 response to amphetamine GO:0001975 9.65 DRD2 DRD3 DRD4
12 prepulse inhibition GO:0060134 9.64 DRD2 DRD3
13 positive regulation of renal sodium excretion GO:0035815 9.64 DRD2 DRD3
14 negative regulation of voltage-gated calcium channel activity GO:1901386 9.63 DRD2 DRD4
15 regulation of synaptic transmission, GABAergic GO:0032228 9.63 CNR1 DRD2
16 G-protein coupled receptor internalization GO:0002031 9.62 DRD2 DRD3
17 cellular aldehyde metabolic process GO:0006081 9.61 AKR1A1 ALDH9A1
18 regulation of cAMP metabolic process GO:0030814 9.61 DRD2 DRD3
19 arachidonic acid secretion GO:0050482 9.61 DRD2 DRD3 DRD4
20 regulation of dopamine uptake involved in synaptic transmission GO:0051584 9.59 DRD2 DRD3
21 behavioral response to cocaine GO:0048148 9.58 DRD2 DRD3 DRD4
22 negative regulation of dopamine secretion GO:0033602 9.57 CNR1 DRD2
23 negative regulation of dopamine receptor signaling pathway GO:0060160 9.56 DRD2 DRD3
24 positive regulation of dopamine uptake involved in synaptic transmission GO:0051586 9.55 DRD2 DRD4
25 acid secretion GO:0046717 9.54 DRD2 DRD3
26 dopamine receptor signaling pathway GO:0007212 9.54 DRD2 DRD3 DRD4
27 dopamine metabolic process GO:0042417 9.5 DRD2 DRD3 DRD4
28 regulation of locomotion involved in locomotory behavior GO:0090325 9.46 DRD2 DRD3
29 negative regulation of protein secretion GO:0050709 9.43 DRD2 DRD3 DRD4
30 response to ethanol GO:0045471 9.35 CNR1 CYP2E1 DRD2 DRD3 PRL
31 adenylate cyclase-inhibiting dopamine receptor signaling pathway GO:0007195 9.33 DRD2 DRD3 DRD4
32 response to histamine GO:0034776 8.8 DRD2 DRD3 DRD4

Molecular functions related to Alcohol Abuse according to GeneCards Suite gene sharing:

id Name GO ID Score Top Affiliating Genes
1 drug binding GO:0008144 9.56 CNR1 DRD2 DRD3 DRD4
2 dopamine binding GO:0035240 9.33 DRD2 DRD3 DRD4
3 aldehyde dehydrogenase (NAD) activity GO:0004029 9.32 ALDH2 ALDH9A1
4 dopamine neurotransmitter receptor activity, coupled via Gi/Go GO:0001591 9.13 DRD2 DRD3 DRD4
5 dopamine neurotransmitter receptor activity GO:0004952 8.8 DRD2 DRD3 DRD4

Sources for Alcohol Abuse

3 CDC
7 CNVD
9 Cosmic
10 dbSNP
11 DGIdb
16 ExPASy
18 FMA
28 GO
29 GTR
30 HGMD
31 HMDB
32 HPO
33 ICD10
34 ICD10 via Orphanet
35 ICD9CM
36 IUPHAR
37 KEGG
38 LifeMap
40 MedGen
42 MeSH
43 MESH via Orphanet
44 MGI
46 NCI
47 NCIt
48 NDF-RT
51 NINDS
52 Novoseek
54 OMIM
55 OMIM via Orphanet
59 PubMed
60 QIAGEN
65 SNOMED-CT via Orphanet
67 TGDB
68 Tocris
69 UMLS
70 UMLS via Orphanet
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