Alcohol Abuse malady

Wikipedia: Alcohol abuse, as described in the DSM-IV, is a psychiatric diagnosis describing the recurring use of...⁴⁴ more...

MalaCards: Alcohol Abuse, also known as ethanol abuse, is related to alcoholism and hepatitis. An important gene associated with Alcohol Abuse is GGT1 (gamma-glutamyltransferase 1), and among its related pathways are Trafficking of GluR2-containing AMPA receptors and Glutathione metabolism. The compounds nicotine and methamphetamine have been mentioned in the context of this disorder. Affiliated tissues include brain, cortex and liver, and related mouse phenotypes are endocrine/exocrine gland and hematopoietic system.

Disease Ontology: A substance abuse that involves the recurring use of alcoholic beverages despite negative consequences.⁶

Aliases & Descriptions:

alcohol abuse 6 8 32 43 ethanol abuse 6

Diseases related to alcohol abuse by text searches and GeneDecks gene sharing:

(show top 50)    (show all 511)

id	Related Disease	Score	Top Affiliating Genes
1	alcoholism	36.1	GSR, GPT, HTR1B, HTR2A, ALDH2, ALDH9A1
2	hepatitis	30.5	GPT, TIMP1, SLC17A5
3	osteonecrosis	29.0	COG2, APOA1, ALDH2, CAT, NR3C1, TF
4	substance abuse	28.3	GTS, GPT, HTR1B, ALDH2, DRD2, DRD3
5	adhd	28.0	GTS, ANKK1, HTR1B, HTR2A, DRD2, DRD3
6	tourette syndrome	28.0	GTS, HTR2A, DRD2, DRD3, COMT, ACP1
7	viral hepatitis	27.0	UROD, LCAT, B2M, GSR, GPT, IGHE
8	alcohol dependence	26.6	AVP, MMP9, ANKK1, GPT, HTR1B, HTR2A
9	anemia	23.5	UROD, LCAT, B2M, GSR, GSS, FECH
10	neurodegeneration	22.8	BRAF, AVP, CETP, MMP9, GSR, GSS
11	esophagitis	22.6	BRAF, MMP9, GSR, MDK, ANPEP, GPT
12	carcinoma	18.4	BRAF, CLEC3B, UROD, B2M, AVP, MMP9
13	opiate dependence	13.8	DRD2, DRD3, CREB1, COMT
14	social phobia	13.8	DRD2, COMT, SLC6A4
15	siderosis	13.8	UROD, GPT, HFE, TF
16	striatonigral degeneration	13.8	DRD2, RPS27A, SLC6A3
17	drug addiction	13.8	DRD2, DRD3, CREB1, SLC6A3
18	cognitive disease	13.7	DRD3, COMT, SLC6A3, GAL
19	pathological gambling	13.7	DRD2, DRD3, SLC6A3, SLC6A4
20	manic-depressive illness	13.7	DRD2, DRD3, SLC6A3, SLC6A4
21	intrahepatic cholestasis of pregnancy	13.7	GPT, ABCB7, SLC17A5, GGT1
22	galactosemia	13.7	FECH, GPT, ABCB7, SLC17A5, GGT1
23	choledocholithiasis	13.7	GPT, SLC17A5, GGT1
24	bilirubin metabolic disorder	13.7	GPT, HP, SLC17A5, GGT1
25	acute intermittent porphyria	13.7	UROD, AVP, TF
26	movement disease	13.7	DRD2, DRD3, RPS27A, SLC6A3
27	novelty seeking personality	13.7	DRD2, COMT, SLC6A2
28	fatty liver disease	13.7	CYP2E1, SLC17A5, ADIPOQ
29	personality disorder	13.7	HTR1B, DRD2, DRD3, SLC6A3, SLC6A4
30	erythropoietic protoporphyria	13.7	FECH, CYP2E1, TF
31	growth mental deficiency syndrome of myhre	13.7	AKR1A1, DRD2, DRD3, COMT, SLC6A3, SLC6A4
32	hemoglobinopathy	13.7	HP, HFE, TF
33	hepatitis b	13.7	GPT, CAT, ABCB7, SLC17A5, GGT1
34	alcoholic pancreatitis	13.6	ALDH2, CAT, CYP2E1, SLC17A5
35	aggressive digital papillary adenocarcinoma	13.6	HTR1B, DRD2, DRD3, COMT, SLC6A4
36	porphyria cutanea tarda	13.6	UROD, FECH, CYP2E1, HFE, TF, SLC17A5
37	variegate porphyria	13.6	UROD, GSR, HFE
38	intrahepatic cholestasis	13.6	LCAT, CETP, GPT, ABCB7, SLC17A5, GGT1
39	alcoholic hepatitis	13.6	APOA1, GPT, RPS27A, SLC17A5, GGT1
40	alcoholic psychosis	13.6	HTR2A, SLC6A3, SLC6A4
41	hemochromatosis	13.6	B2M, HP, HFE, TF
42	splenomegaly	13.6	LCAT, GPT, HP, SLC17A5
43	pmm2-cdg (cdg-ia)	13.6	HP, TF, PMM2, NEU1
44	major affective disorder	13.6	HTR2A, DRD2, SLC6A4
45	gilles de la tourette syndrome	13.5	GTS, DRD2, COMT, SLC6A3, SLC1A3, ADRA2A
46	sideroblastic anemia	13.5	UROD, CYCS, ABCB7
47	protein-energy malnutrition	13.5	GSR, GPT, HP, TF, GGT1
48	favism	13.5	CAT, HP, ACP1
49	tic disorder	13.5	HTR2A, DRD2, ACP1
50	conduct disorder	13.5	MB, ALDH2, DRD2, COMT, SLC6A3, SLC6A4

Approved drugs:

Drug clinical trials:

MalaCards organs/tissues related to alcohol abuse:

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MGI Mouse Phenotypes related to alcohol abuse:

²⁵ (show all 19)

id	Description	MGI Source Accession	Score	Top Affiliating Genes
1	endocrine/exocrine gland phenotype	MP:0005379	9.6	GGT1, GAL, KRAS, HTR2A, HTR1B
2	hematopoietic system phenotype	MP:0005397	9.1	KRAS, CYCS, AKR1A1, IGHE, MB, MDK
3	renal/urinary system phenotype	MP:0005367	8.7	AGTR1, EGFR, KRAS, DRD3, DRD2, AKR1A1
4	liver/biliary system phenotype	MP:0005370	8.3	SOD1, PRL, ABCB7, EGFR, CYP2E1, DRD2
5	skeleton phenotype	MP:0005390	8.1	NEU1, EGFR, NR3C1, CYCS, DRD2, AKR1A1
6	vision/eye phenotype	MP:0005391	7.8	NEU1, SLC17A5, SLC1A3, SOD1, EGFR, KRAS
7	reproductive system phenotype	MP:0005389	7.5	COMT, KRAS, TIMP1, PRL, SLC6A3, ADIPOQ
8	muscle phenotype	MP:0005369	7.1	EGFR, SOD1, SLC6A3, SLC6A4, NEU1, ADIPOQ
9	normal phenotype	MP:0002873	7.1	KRAS, EGFR, HFE, PMM2, SLC6A3, SLC6A4
10	integument phenotype	MP:0010771	7.0	PRL, SLC6A2, SLC6A3, SLC6A4, NEU1, GAL
11	tumorigenesis	MP:0002006	7.0	KRAS, EGFR, TIMP1, PRL, ADIPOQ, CYP2E1
12	mortality/aging	MP:0010768	6.8	EGFR, ABCB7, HFE, AGTR1, TF, PMM2
13	immune system phenotype	MP:0005387	6.5	EGFR, ACP1, HFE, AGTR1, PRL, NEU1
14	growth/size phenotype	MP:0005378	6.1	PMM2, AGTR1, HFE, ACP1, ABCB7, SLC6A2
15	nervous system phenotype	MP:0003631	5.9	SLC6A2, PMM2, PRL, ABCB7, EGFR, SLC6A3
16	cellular phenotype	MP:0005384	5.6	KRAS, EGFR, ABCB7, ACP1, SOD1, PMM2
17	cardiovascular system phenotype	MP:0005385	5.3	ABCB7, EGFR, KRAS, COMT, CREB1, AGTR1
18	behavior/neurological phenotype	MP:0005386	5.0	SOD1, PRL, HFE, KRAS, COMT, CREB1
19	homeostasis/metabolism phenotype	MP:0005376	2.8	GGT1, TF, TIMP1, AGTR1, HFE, ABCB7

Articles related to alcohol abuse:

(show top 50)    (show all 73)

id	Title	Authors	Year	Affiliating Genes
1	Glucocorticoid receptor (NR3C1) gene polymorphisms an d onset of alcohol abuse in adolescents. (20731635)	DesriviA"res S.... Schumann G.	2010	NR3C1
2	Multiple polymorphisms in genes of the adrenergic str ess system confer vulnerability to alcohol abuse. (21070505)	Clarke T.K.... Schumann G.	2010	SLC6A2, ADRA2A
3	Elevated adiponectin serum levels in patients with ch ronic alcohol abuse rapidly decline during alcohol withdrawal. (19067777)	Buechler C.... Hellerbrand C.	2009	ADIPOQ
4	The effect of chronic alcohol abuse on the lipids, lipoproteins and apolipoproteins concentrations in the sera (18702334)	Krawiec A.... Szmitkowski M.	2008	APOA1
5	K-ras Mutation, HPV Infection and Smoking or Alcohol Abuse Positively Correlate with Esophageal Squamous Carcinoma. (18592405)	Lyronis I.D.... Spandidos D.A.	2008	BRAF, KRAS
6	Acute and chronic alcohol abuse and work (19288791)	Riboldi L.... Bordini L.	2008	SLC17A5
7	Activation of protein tyrosine kinases and matrix metalloproteinases causes blood-brain barrier injury: Novel mechanism for neurodegeneration associated with alcohol abuse. (17943953)	Haorah J.... Persidsky Y.	2008	TIMP1, ACP1
8	Association of the functional serotonin transporter promoter polymorphism (5-HTTLPR) with externalizing and internalizing aggressivity and alcohol abuse (19331786)	Pombo S.... Cardoso N.	2008	SLC6A4
9	Alcohol abuse and related factors in Asia. (19012127)	Chen C.C.... Yin S.J.	2008	AKR1A1, ALDH9A1
10	Between- and within-family association test of the dopamine receptor D2 TaqIA polymorphism and alcohol abuse and dependence in a general population sample of adults. (17446975)	Haberstick B.C.... Hewitt J.K.	2007	DRD2, ANKK1
11	The diagnostic accuracy of carbohydrate-deficient tra nsferrin, sialic acid and commonly used markers of alcohol abuse during abstine nce. (16087169)	Chrostek L.... Korcz W.	2006	GGT1
12	New and traditional laboratory markers of alcohol abuse in hospitalized alcohol dependent men (17037822)	Chrostek L.... Korcz W.	2006	GGT1, SLC17A5
13	Combining markers of nephrotoxicity and hepatotoxicity for improved monitoring and detection of chronic alcohol abuse. (17163821)	Taracha E.... PA8aA_nik A.	2006	GGT1
14	Defective glycosylation of cholesteryl ester transfer protein in plasma from alcohol abusers. (16203750)	Liinamaa M.J.... Savolainen M.J.	2006	CETP
15	Use of laboratory markers and the audit questionnaire by primary care physicians to detect alcohol abuse by patients. (16215269)	Aalto M.... SeppAo K.	2005	GPT
16	Rhabdomyolysis and acute renal failure after strenuous exercise and alcohol abuse: case report and literature review. (15821814)	Daher E.d.e. .F.... Bezerra G.P.	2005	MB
17	A form of DISC1 enriched in nucleus: altered subcellular distribution in orbitofrontal cortex in psychosis and substance/alcohol abuse. (15657124)	Sawamura N.... Sawa A.	2005	DISC1
18	Biochemical indicators and cardiac function tests in chronic alcohol abusers. (15849844)	AvA9aroglu D.... Kayrin L.	2005	SOD1, GGT1, GPT
19	Cytochrome P450 2E1 high activity polymorphism in alcohol abuse and end-organ disease. (16425414)	Cartmell M.T.... Kingsnorth A.N.	2005	CYP2E1
20	Genetic polymorphism in ethanol metabolism: acetaldehyde contribution to alcohol abuse and alcoholism. (15164086)	Quertemont E.	2004	CAT, AKR1A1, ALDH9A1
21	Blood biomarkers of alcohol abuse. (14994647)	Bilban M.... Karlovsek M.Z.	2003	GGT1, GPT, SLC17A5
22	Transcription profiling reveals mitochondrial, ubiqui tin and signaling systems abnormalities in postmortem brains from subjects with a history of alcohol abuse or dependence. (12774316)	Sokolov B.P.... Aston C.	2003	RPS27A
23	Anxiety and alcohol abuse disorders: a common role for CREB and its target, the neuropeptide Y gene. (12967770)	Pandey S.C.	2003	CREB1
24	Rhabdomyolysis, hepatitis and multiple hematological disorders associated with alcohol abuse: a case report. (12939102)	Yoshida Y.... Kubota K.	2002	MB
25	Matrix metalloproteinase-9 is elevated in serum of alcohol abusers. (11952806)	Sillanaukee P.... Nikkari S.T.	2002	MMP9
26	Examination of a CYP2E1 repeat polymorphism in a monkey model of alcohol abuse. (11505041)	Walker S.J.... Vrana K.E.	2001	CYP2E1
27	Studies on the oxidative stress in alcohol abusers in China. (11723717)	Zhou J.F.... Chen P.	2001	SOD1, CAT
28	Usefulness of microheterogeneity of serum alpha 1-acidglycoprotein as a marker for alcohol abuse. (11839463)	Tsutsumi M.... Takase S.	2001	TF
29	Improved diagnostic classification of alcohol abusers by combining carbohydrate-deficient transferrin and gamma-glutamyltransferase. (11274018)	Sillanaukee P.... Olsson U.	2001	GGT1
30	Objective diagnosis of alcohol abuse: compared values of carbohydrate-deficient transferrin (CDT), gamma-glutamyl transferase (GGT), and mean corpuscular volume (MCV). (11003208)	Reynaud M.... Gillet C.	2000	GGT1
31	Mean cell volume and gamma-glutamyl transferase are superior to carbohydrate-deficient transferrin and hemoglobin-acetaldehyde adducts in the follow-up of pregnant women with alcohol abuse. (10830762)	Sarkola T.... HalmesmAoki E.	2000	TF, GGT1
32	Association of 5HT2A receptor gene polymorphism and alcohol abuse with behavior problems. (11121184)	Hwu H.G.... Chen C.H.	2000	HTR2A
33	Microheterogeneity of serum glycoproteins in patients with chronic alcohol abuse compared with carbohydrate-deficient glycoprotein syndrome type I. (10471642)	Henry H.... Bachmann C.	1999	TF, PMM2, NEU1
34	CDT (desialylated transferrin)--a new biochemical marker of alcohol abuse (10786224)	Chrostek L.... Szmitkowski M.	1999	TF
35	Determination of biological markers for alcohol abuse. (9700562)	Musshoff F.... Daldrup T.	1998	GPT
36	A simple method for carbohydrate-deficient transferrin measurements in patients with alcohol abuse and hepato-gastrointestinal diseases. (9547899)	Cotton F.... Gulbis B.	1998	GGT1, ABCB7
37	Increased expression of epidermal growth factor receptor in normal epithelium adjacent to head and neck carcinomas independent of tobacco and alcohol abuse. (9655037)	van Oijen M.G.... Slootweg P.J.	1998	EGFR
38	Macrocytic anemia with anisocytosis due to alcohol abuse and vitamin B6 deficiency (9866426)	Iwama H.... Toyama K.	1998	FECH, UROD
39	Free radicals and not acetaldehyde influence the circulating levels of glutathione after acute or chronic alcohol abuse: in vivo and in vitro studies. (9646199)	Loguercio C.... Nardi G.	1997	GSS
40	Is carbohydrate-deficient transferrin a specific marker for alcohol abuse? A study in patients with chronic viral hepatitis. (9347098)	Perret R.... Gonvers J.J.	1997	TF
41	Genetic markers of alcohol abuse. (9118563)	Ferguson R.A.... Goldberg D.M.	1997	DRD2, AKR1A1, ALDH9A1
42	Incidence of alcohol abuse among patients with emerg ency admissions to a psychiatric department. Evaluation based on clinical and b iochemical markers (7645101)	Nitschke K.... Rosenberg R.	1995	GGT1
43	Increased serum IgE in alcohol abusers. (7584688)	Gonzalez-Quintela A.... Barrio E.	1995	IGHE
44	Carbohydrate deficient transferrin--a reliable marker of alcohol abuse? (7652979)	Bathum L.	1995	TF
45	Allelic D variants of transferrin in evaluation of alcohol abuse: differential diagnosis by isoelectric focusing-immunoblotting-laser densitometry. (7955382)	Bean P.... Peter J.B.	1994	TF
46	Genetic factors in substance abuse based on studies of Tourette syndrome and ADHD probands and relatives. II. Alcohol abuse. (8082551)	Comings D.E.	1994	GTS
47	Monosaccharide composition of haptoglobin in liver diseases and alcohol abuse: large changes in glycosylation associated with alcoholic liver disease. (7955423)	Mann A.C.... Turner G.A.	1994	HP
48	A new approach to quantitate carbohydrate-deficient transferrin isoforms in alcohol abusers: partial iron saturation in isoelectric focusing/immunoblotting and laser densitometry. (8116825)	Bean P.... Peter J.B.	1993	TF
49	Renal tubular dysfunction in chronic alcohol abuse--effects of abstinence. (8247056)	De Marchi S.... Bartoli E.	1993	B2M
50	Serum beta-hexosaminidase and alpha-mannosidase activ ities as markers of alcohol abuse. (1673822)	Wehr H.... Matsumoto H.	1991	GGT1

Genes related to alcohol abuse according to GeneCards:

(show top 50)    (show all 66)

id	Symbol	Description	Score	GeneCards Section Context
1	GGT1	gamma-glutamyltransferase 1	11.0	Publications
2	ABCB7	ATP-binding cassette, sub-family B (MDR/TAP), member 7	11.0	Publications
3	AKR1A1	aldo-keto reductase family 1, member A1 (aldehyde reductase)	11.0	Publications
4	ALDH9A1	aldehyde dehydrogenase 9 family, member A1	11.0	Publications
5	TF	transferrin	11.0	Publications
6	SLC17A5	solute carrier family 17 (anion/sugar transporter), member 5	11.0	Publications
7	GPT	glutamic-pyruvate transaminase (alanine aminotransferase)	11.0	Publications
8	LCAT	lecithin-cholesterol acyltransferase	11.0
9	COG2	component of oligomeric golgi complex 2	11.0
10	CYP2E1	cytochrome P450, family 2, subfamily E, polypeptide 1	11.0	Publications
11	GAL	galanin prepropeptide	11.0
12	ADH1C	alcohol dehydrogenase 1C (class I), gamma polypeptide	11.0
13	ALDH2	aldehyde dehydrogenase 2 family (mitochondrial)	11.0	Publications
14	CREB1	cAMP responsive element binding protein 1	11.0	Publications
15	HFE	hemochromatosis	11.0
16	SLC6A4	solute carrier family 6 (neurotransmitter transporter, serotonin), member 4	11.0	Publications
17	DRD2	dopamine receptor D2	11.0	Publications
18	RPS27A	ribosomal protein S27a	11.0	Publications
19	DRD3	dopamine receptor D3	11.0
20	SLC6A3	solute carrier family 6 (neurotransmitter transporter, dopamine), member 3	11.0
21	COMT	catechol-O-methyltransferase	11.0
22	GTS	Gilles de la Tourette syndrome	11.0	Publications
23	CLEC3B	C-type lectin domain family 3, member B	11.0	Publications
24	ANKK1	ankyrin repeat and kinase domain containing 1	11.0	Publications
25	MDK	midkine (neurite growth-promoting factor 2)	11.0	Publications
26	UROD	uroporphyrinogen decarboxylase	11.0	Publications
27	GSS	glutathione synthetase	11.0	Publications
28	DISC1	disrupted in schizophrenia 1	11.0	Publications
29	UBL3	ubiquitin-like 3	11.0
30	PMM2	phosphomannomutase 2	11.0	Publications
31	HTR1B	5-hydroxytryptamine (serotonin) receptor 1B, G protein-coupled	11.0	Publications
32	PLTP	phospholipid transfer protein	11.0	Publications
33	SLC1A3	solute carrier family 1 (glial high affinity glutamate transporter), member 3	11.0	Publications
34	FECH	ferrochelatase	11.0	Publications
35	ADRA2A	adrenoceptor alpha 2A	11.0	Publications
36	APOA5	apolipoprotein A-V	11.0
37	AVP	arginine vasopressin	11.0
38	ABHD6	abhydrolase domain containing 6	11.0
39	NEU1	sialidase 1 (lysosomal sialidase)	11.0	Publications
40	MB	myoglobin	11.0	Publications
41	ANPEP	alanyl (membrane) aminopeptidase	11.0	Publications
42	HP	haptoglobin	11.0	Publications
43	SLC6A2	solute carrier family 6 (neurotransmitter transporter, noradrenalin), member 2	11.0	Publications
44	GRIA2	glutamate receptor, ionotropic, AMPA 2	11.0	Publications
45	GRIA3	glutamate receptor, ionotropic, AMPA 3	11.0	Publications
46	ACP1	acid phosphatase 1, soluble	11.0	Publications
47	B2M	beta-2-microglobulin	11.0	Publications
48	CAT	catalase	11.0	Publications
49	CETP	cholesteryl ester transfer protein, plasma	11.0	Publications
50	GRIA1	glutamate receptor, ionotropic, AMPA 1	11.0	Publications

Pathways related to alcohol abuse according to GeneDecks:

(show all 20)

id	Pathway	Score	Top Affiliating Genes
1	Trafficking of GluR2-containing AMPA receptors38	10.2	GRIA3, GRIA2, GRIA1
2	Glutathione metabolism10	10.1	GSR, GSS, ANPEP, GGT1
3	Glutathione metabolism41	10.1	GGT1, ANPEP, GSS, GSR
4	Statin Pathway, Pharmacodynamics34	10.1	PLTP, APOA5, APOA1, LCAT
5	Pathway_PA16598033734	10.1	SOD1, CAT, GSR
6	Oxidative Stress Pathway (Erythrocyte)34	10.1	SOD1, CAT, GSR
7	Oxidative Stress Pathway (Erythrocyte)34	10.1	SOD1, CAT, GSR
8	Cyclophosphamide Pathway, Pharmacodynamics34	10.0	ALDH2, AKR1A1, ADH1C
9	Amine ligand-binding receptors38	9.9	ADRA2A, DRD3, DRD2, HTR2A, HTR1B
10	Glutamic acid signaling10	9.9	GRIA1, GRIA2, GRIA3, SLC1A3
11	Glutathione metabolism20	9.9	GGT1, ANPEP, GSS, GSR
12	CREB Pathway36	9.8	CREB1, MDK, GRIA3, GRIA2, GRIA1
13	Amyotrophic lateral sclerosis (ALS)20	9.7	SOD1, CYCS, CAT, GRIA2, GRIA1
14	Pathogenesis of ALS36	9.6	GRIA1, SLC1A3, SOD1, CYCS, GRIA3, GRIA2
15	Metabolic pathways20	9.5	GGT1, ADH1C, PMM2, COMT, CYP2E1, AKR1A1
16	Long-term depression20	9.5	KRAS, GRIA3, GRIA2, GRIA1, BRAF
17	Neuroscience3	9.5	SOD1, CREB1, GRIA3, GRIA2, GRIA1, SLC1A3
18	Bladder cancer20	9.0	EGFR, KRAS, MMP9, BRAF
19	Intracellular Calcium Signaling36	8.6	TIMP1, EGFR, CREB1, HTR2A, HTR1B, MDK
20	Neuroactive ligand-receptor interaction20	7.8	ADRA2A, PRL, AGTR1, NR3C1, DRD3, DRD2

Compounds related to alcohol abuse according to GeneDecks:

(show top 50)    (show all 456)

id	Compound	Score	Top Affiliating Genes
1	nicotine32 34 9 9	13.4	ANKK1, GPT, CYP2E1, SLC6A2, SLC17A5
2	methamphetamine32 9 9	11.8	SLC6A2, COMT, SLC6A4, ADRA2A, RPS27A, CREB1
3	ascorbic acid32 18	10.8	TF, HFE, ACP1, COMT, CYP2E1, DRD2
4	disulfiram32 42 9 9	12.6	CYP2E1, AKR1A1, ALDH9A1, ALDH2, GPT, GSR
5	acetaldehyde32 18	10.5	CETP, LCAT, SLC17A5, TF, ACP1, CYP2E1
6	haloperidol32 34 9 9	12.4	AGTR1, CREB1, DRD3, AKR1A1, HTR2A, GPT
7	4-hydroxynonenal32 18	10.4	SOD1, RPS27A, CREB1, CYCS, CYP2E1, AKR1A1
8	6-hydroxydopamine32	9.3	CAT, CREB1, SLC6A2, DRD3, RPS27A, COMT
9	choline32 9 18 9	12.3	APOA1, GPT, IGHE, ALDH9A1, ACP1, TF
10	phenobarbital32 9 9	11.3	AKR1A1, ALDH9A1, GPT, APOA1, GRIA2, GRIA1
11	ethanol32 34 9 18 9	13.3	GPT, ANKK1, ANPEP, AVP, UROD, AGTR1
12	h2o232	9.2	APOA1, MB, ALDH9A1, HP, AKR1A1, CREB1
13	levodopa32 9 9	11.2	DRD2, AKR1A1, HTR1B, DRD3, CREB1, RPS27A
14	bromocriptine32 9 9	11.1	GAL, ADRA2A, PRL, DRD3, HTR2A, CREB1
15	heparin32 9 18 9	12.0	AGTR1, TIMP1, ADIPOQ, ABCB7, HP, APOA5
16	n acetylcysteine32	9.0	MMP9, GSS, SLC17A5, TIMP1, EGFR, RPS27A
17	vitamin-e32	8.9	SLC17A5, COG2, B2M, GSR, GSS, SOD1
18	formaldehyde32 18	9.9	CYP2E1, AKR1A1, CAT, ANPEP, ALDH9A1, ALDH2
19	risperidone32 34 9 18 9	12.9	ADRA2A, SLC6A4, GPT, SLC17A5, SLC6A3, PRL
20	silymarin32	8.8	GGT1, SLC17A5, SOD1, ABCB7, EGFR, CYCS
21	uric acid32 18	9.7	GGT1, ADIPOQ, SLC17A5, SOD1, B2M, AVP
22	clozapine32 34 9 9	11.7	ADIPOQ, ANKK1, ADRA2A, SLC6A4, SLC6A3, PRL
23	olanzapine32 34 9 18 9	12.6	SLC17A5, SLC6A3, PRL, COMT, DRD3, DRD2
24	pramipexole32 9 9	10.6	SLC6A3, ADRA2A, DRD2, PRL, COMT, DRD3
25	creatinine32	8.5	ADIPOQ, TF, AGTR1, ABCB7, RPS27A, CYP2E1
26	gaba32 42	9.4	GAL, SLC6A4, SLC1A3, SLC6A3, SLC6A2, TF
27	5-hydroxytryptamine32	8.4	AKR1A1, HTR1B, SLC6A4, HTR2A, ALDH9A1, GAL
28	folate32	8.3	TIMP1, IGHE, ALDH2, ALDH9A1, HP, MMP9
29	alpha tocopherol32	8.3	APOA1, GSR, MMP9, CETP, LCAT, MB
30	epinephrine32 9 18 9	11.2	SLC17A5, MMP9, GSR, MB, IGHE, HP
31	glutamine32	8.0	RPS27A, CREB1, NR3C1, AKR1A1, ALDH2, IGHE
32	adenylate32	8.0	GAL, ADIPOQ, ADRA2A, SLC1A3, SLC6A2, TIMP1
33	acetylcholine32 9 18 9	10.9	ACP1, APOA1, MB, IGHE, NR3C1, CREB1
34	cholesterol32 9 18 9	10.9	CETP, APOA5, APOA1, ANPEP, GPT, SLC17A5
35	cysteine32	7.9	SLC6A2, TIMP1, AGTR1, COMT, RPS27A, PLTP
36	dopamine32 9 18 9	10.8	NEU1, CYP2E1, DISC1, DRD3, DRD2, AKR1A1
37	thyroxine32 18	8.7	GGT1, ADIPOQ, SLC17A5, PRL, TF, ABCB7
38	cocaine32 9 9	9.7	GGT1, DRD3, DRD2, HTR1B, GPT, MB
39	aspartate32	7.5	MMP9, CETP, B2M, BRAF, ABCB7, RPS27A
40	glutamate32	7.4	ACP1, TIMP1, SLC1A3, ADRA2A, GAL, COMT
41	testosterone32 9 18 9	10.2	GAL, SLC6A4, PRL, HFE, ABCB7, EGFR
42	vitamin a32 9 18 9	10.2	TIMP1, TF, SOD1, SLC17A5, ADIPOQ, ADH1C
43	lipid32	6.9	KRAS, APOA1, MDK, GSR, CETP, LCAT
44	lactate32	6.7	GGT1, ADIPOQ, SLC17A5, SOD1, TF, TIMP1
45	norepinephrine32 9 18 9	9.6	GAL, COMT, CREB1, DRD3, DRD2, ALDH9A1
46	alanine32	6.4	SLC1A3, IGHE, GPT, ANPEP, MB, APOA1
47	arginine32	6.2	SLC6A4, SLC6A3, SOD1, PRL, TIMP1, AGTR1
48	estrogen32	5.7	ADIPOQ, ADRA2A, NEU1, SLC6A4, AKR1A1, HP
49	retinoic acid32 42 18	7.7	TIMP1, ACP1, EGFR, KRAS, COMT, RPS27A
50	serine32	5.0	ANPEP, BRAF, LCAT, B2M, APOA1, FECH

Cellular components related to alcohol abuse according to GeneDecks:

id	Name	GO ID	Score	Top Affiliating Genes
1	endocytic vesicle	GO:030139	10.0	TF, DRD3, DRD2, APOA1
2	high-density lipoprotein particle	GO:034364	10.0	APOA5, APOA1, CETP, LCAT
3	endocytic vesicle membrane	GO:030666	9.9	GRIA1, GRIA2, GRIA3, RPS27A
4	alpha-amino-3-hydroxy-5-methyl-4-isoxazolepropionic acid selective glutamate receptor complex	GO:032281	9.6	GRIA3, GRIA2, GRIA1
5	postsynaptic density	GO:014069	9.4	NR3C1, DISC1, DRD2, GRIA3, GRIA2, GRIA1
6	integral to plasma membrane	GO:005887	8.6	ADRA2A, SLC6A4, SLC17A5, SLC6A3, SLC6A2, AGTR1
7	extracellular space	GO:005615	7.9	ADIPOQ, SOD1, EGFR, HP, APOA5, APOA1
8	extracellular region	GO:005576	7.1	PLTP, TIMP1, TF, PRL, SOD1, ADIPOQ
9	cytosol	GO:005829	7.0	CYCS, NR3C1, RPS27A, COMT, SOD1, PMM2
10	plasma membrane	GO:005886	5.8	BRAF, KRAS, EGFR, HFE, AGTR1, SOD1

Biological processes related to alcohol abuse according to GeneDecks:

(show all 25)

id	Name	GO ID	Score	Top Affiliating Genes
1	neurotransmitter biosynthetic process	GO:042136	10.5	ALDH2, ALDH9A1, COMT, SLC6A3
2	response to cocaine	GO:042220	10.5	SLC6A3, DRD3, DRD2, HTR1B
3	monoamine transport	GO:015844	10.5	SLC6A2, SLC6A3, SLC6A4
4	G-protein coupled receptor internalization	GO:002031	10.5	DRD3, DRD2, HTR1B
5	xenobiotic metabolic process	GO:006805	10.3	GGT1, ADH1C, COMT, CYP2E1, ALDH2, GSS
6	response to light stimulus	GO:009416	10.3	SLC1A3, DRD2, FECH
7	prepulse inhibition	GO:060134	10.3	DRD2, DRD3, SLC6A3
8	auditory behavior	GO:031223	10.3	DRD2, SLC1A3
9	locomotory behavior	GO:007626	10.2	SLC6A3, SOD1, DRD3, DRD2, AVP
10	social behavior	GO:035176	10.2	AVP, DRD3, KRAS, SLC6A4
11	response to nicotine	GO:035094	10.1	AVP, MMP9, DRD2, SLC6A3
12	negative regulation of synaptic transmission, glutamatergic	GO:051967	10.1	DRD2, HTR2A, HTR1B
13	regulation of dopamine secretion	GO:014059	10.0	DRD3, DRD2, HTR2A, HTR1B
14	cholesterol transport	GO:030301	10.0	APOA1, CETP, LCAT
15	lipoprotein metabolic process	GO:042157	10.0	APOA5, APOA1, CETP, LCAT
16	high-density lipoprotein particle remodeling	GO:034375	9.9	LCAT, CETP, APOA1
17	cholesterol metabolic process	GO:008203	9.9	CAT, APOA1, FECH, CETP, LCAT
18	reverse cholesterol transport	GO:043691	9.8	APOA1, CETP, LCAT
19	response to hypoxia	GO:001666	9.5	ADIPOQ, SLC6A4, DRD2, CAT, MB, MMP9
20	cholesterol homeostasis	GO:042632	9.5	LCAT, CETP, APOA1, APOA5
21	response to ethanol	GO:045471	9.4	ADIPOQ, SLC6A3, SOD1, DRD3, HTR1B, FECH
22	positive regulation of MAP kinase activity	GO:043406	9.2	ADRA2A, EGFR, KRAS, HTR2A
23	response to drug	GO:042493	8.7	B2M, GAL, SLC6A4, SLC1A3, SLC6A3, SOD1
24	small molecule metabolic process	GO:044281	8.5	CAT, CYP2E1, CYCS, COMT, NEU1, ADRA2A
25	synaptic transmission	GO:007268	7.9	CREB1, COMT, ACP1, SLC6A2, SLC6A3, SLC1A3

Molecular functions related to alcohol abuse according to GeneDecks:

id	Name	GO ID	Score	Top Affiliating Genes
1	monoamine transmembrane transporter activity	GO:008504	10.2	SLC6A2, SLC6A3, SLC6A4
2	dopamine binding	GO:035240	10.2	DRD2, DRD3, SLC6A3
3	alpha-amino-3-hydroxy-5-methyl-4-isoxazole propionate selective glutamate receptor activity	GO:004971	10.0	GRIA1, GRIA2, GRIA3
4	drug binding	GO:008144	9.6	SLC6A3, DRD3, DRD2, HTR2A, HTR1B
5	protein homodimerization activity	GO:042803	8.7	ADRA2A, SLC6A4, SOD1, NR3C1, CAT, ALDH9A1
6	protein binding	GO:005515	4.8	TIMP1, AGTR1, HFE, ACP1, EGFR, TF