MCID: ALC004
MIFTS: 51

Alcohol Abuse malady

Mental diseases category
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Summaries for Alcohol Abuse

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Sources:
8Disease Ontology, 65Wikipedia, 33MalaCards
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Wikipedia:65 Alcohol abuse, as described in the DSM-IV, is a psychiatric diagnosis describing the recurring use of... more...

MalaCards: Alcohol Abuse, also known as ethanol abuse, is related to alcohol dependence and hepatitis. An important gene associated with Alcohol Abuse is ABCB7 (ATP-binding cassette, sub-family B (MDR/TAP), member 7), and among its related pathways are Transport of glucose and other sugars, bile salts and organic acids, metal ions and amine compounds and Fatty acid metabolism. The compounds 5-hydroxytryptophol and alpha-hydroxybutyrate have been mentioned in the context of this disorder. Affiliated tissues include liver, brain and testes, and related mouse phenotypes are growth/size/body and homeostasis/metabolism.

Disease Ontology:8 A substance abuse that involves the recurring use of alcoholic beverages despite negative consequences.

Aliases & Classifications for Alcohol Abuse

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Sources:
8Disease Ontology, 45Novoseek, 62UMLS, 58SNOMED-CT, 40NCIt, 27ICD9CM, 35MeSH
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Classifications:

Malacards categories (disease lists): (See all malacards categories)
Anatomical: Mental diseases


Aliases & Descriptions:

alcohol abuse 8 45 62
ethanol abuse 8


External Ids:

Disease Ontology8 DOID:1574
NCIt40 C20701
SNOMED-CT58 304606004, 15167005
ICD9CM27 305.00, 305.0
MeSH35 D000437

Related Diseases for Alcohol Abuse

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Sources:
17GeneCards, 18GeneDecks
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Diseases in the Alcohol Abuse family:

Alcohol Sensitivity, Acute

Diseases related to Alcohol Abuse via text searches within MalaCards or GeneCards/GeneDecks gene sharing:

(show top 50)    (show all 131)
idRelated DiseaseScoreTop Affiliating Genes
1alcohol dependence31.0TF, ALDH2
2hepatitis31.0SLC17A5, GPT
3viral hepatitis30.5GPT, SLC17A5, ABCB7
4pancreatitis30.5CYP2E1, ADH1C, ALDH2, SLC17A5
5hepatocellular carcinoma30.4GPT, ALDH2, SLC17A5, CYP2E1, TF, ABCB7
6substance abuse30.4DRD3, TF, CYP2E1, ALDH2
7hepatitis c30.3TF, ABCB7, GPT, SLC17A5, CYP2E1
8alcoholic pancreatitis30.2ALDH2, ADH1C, CYP2E1
9alcoholic hepatitis30.1SLC17A5, GPT
10hepatitis b30.1GPT, ABCB7, SLC17A5
11leukopenia30.1ABCB7, SLC17A5, GPT
12liver cirrhosis30.0ABCB7, TF, CYP2E1, GPT, SLC17A5, ADH1C
13acute pancreatitis29.9ALDH2, ABCB7, GPT, ADH1C, SLC17A5
14obesity29.9ALDH2, ABCB7, CYP2E1, SLC17A5, GPT
15alcoholic liver cirrhosis29.8SLC17A5, ALDH2, ADH1C, TF, CYP2E1, GPT
16liver disease10.5
17schizophrenia10.4
18wernicke-korsakoff syndrome10.4
19bipolar disorder10.3
20brain injury10.3
21traumatic brain injury10.3
22personality disorder10.3
23pneumonia10.3
24neuronitis10.2
25pathological gambling10.2
26eating disorder10.2
27esophagitis10.2
28neuropathy10.2
29madelung disease10.2
30sepsis10.2
31hiv/aids10.2
32fatty liver disease10.1CYP2E1
33dengue disease10.1ABCB7, SLC17A5
34pyridoxine deficiency10.0GPT, SLC17A5
35obstructive jaundice10.0GPT, SLC17A5
36burns10.0
37atrioventricular block10.0
38axonal neuropathy10.0
39pulmonary tuberculosis10.0
40antisocial personality disorder10.0
41granulomatous hepatitis10.0
42alexithymia10.0
43frontotemporal dementia10.0
44conduct disorder10.0
45panic disorder10.0
46central pontine myelinolysis10.0
47cocaine dependence10.0
48cocaine abuse10.0
49anorexia nervosa10.0
50infertility10.0

Graphical network of the top 20 diseases related to Alcohol Abuse:



Diseases related to alcohol abuse

Symptoms for Alcohol Abuse

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Drugs & Therapeutics for Alcohol Abuse

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Sources:
42NIH Clinical Center, 6ClinicalTrials, 62UMLS, 41NDF-RT
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Drug clinical trials:

Search ClinicalTrials for Alcohol Abuse

Search NIH Clinical Center for Alcohol Abuse

Genetic Tests for Alcohol Abuse

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Anatomical Context for Alcohol Abuse

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Sources:
33MalaCards
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MalaCards organs/tissues related to Alcohol Abuse:

33
Liver, Brain, Testes, Lung, Heart, Bone, Amygdala, Cortex, Endothelial, Breast, Thymus, Whole blood, Prefrontal cortex

Animal Models for Alcohol Abuse or affiliated genes

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Sources:
37MGI
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MGI Mouse Phenotypes related to Alcohol Abuse:

37
idDescriptionMGI Source AccessionScoreTop Affiliating Genes
1MP:00053787.5SLC17A5, DRD3, ALDH2, ADH1C, TF, ABCB7
2MP:00053766.9SLC17A5, ABCB7, TF, CYP2E1, ADH1C, ALDH2
3MP:00107686.7ABCB7, TF, CYP2E1, ADH1C, ALDH2, DRD3

Publications for Alcohol Abuse

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Sources:
52PubMed
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Articles related to Alcohol Abuse:

(show top 50)    (show all 559)
idTitleAuthorsYear
1
2013 reviewers, the american journal of drug and alcohol abuse. (24359510)
2014
2
Mental Health and Migration: Depression, Alcohol Abuse, and Access to Health Care Among Migrants in Central Asia. (24186359)
2013
3
Cardiovascular morbidity, risk of cancer and alcohol abuse in psoriasis: systematic literature reviews and expert opinion. (23845147)
2013
4
Suicide behavior in parents with alcohol abuse problems and suicide behavior in their offspring-adult offspring and counselor perspectives. (22283687)
2012
5
Patterns of protective factors in an intervention for the prevention of suicide and alcohol abuse with Yup'ik Alaska Native youth. (22931082)
2012
6
Protein biomarkers of alcohol abuse. (22967079)
2012
7
Use of the screening suggested by the National Institute on Alcohol Abuse and Alcoholism and of a newly derived tool for the detection of unhealthy alcohol drinkers among surgical patients. (22152670)
2012
8
A mouse model for adolescent alcohol abuse: stunted growth and effects in brain. (22433022)
2012
9
Central American mothers report family history of depression and alcohol abuse as a predictor of teenage health risk behaviors. (21040088)
2010
10
Suicidal behavior and alcohol abuse. (20617037)
2010
11
Parent training with behavioral couples therapy for fathers' alcohol abuse: effects on substance use, parental relationship, parenting, and CPS involvement. (19502478)
2009
12
Strategy for increasing detection rates of drug and alcohol abuse in paediatric emergency departments. (19555445)
2009
13
Suicidal behavior in adolescents with comorbid depression and alcohol abuse. (19461576)
2009
14
Alcohol abuse may lead to depression. (19662693)
2009
15
Correlates of and relationship among lifetime alcohol abuse and alcohol dependence in older community residents in Brazil. (20191090)
2009
16
Biochemical and neurotransmitter changes implicated in alcohol-induced brain damage in chronic or 'binge drinking' alcohol abuse. (19155229)
2009
17
Alcohol abuse enhances pulmonary edema in acute respiratory distress syndrome. (19572988)
2009
18
Elevated adiponectin serum levels in patients with chronic alcohol abuse rapidly decline during alcohol withdrawal. (19067777)
2009
19
Alcohol abuse in adolescents. (18305075)
2008
20
Pilot study of interpersonal psychotherapy versus supportive psychotherapy for dysthymic patients with secondary alcohol abuse or dependence. (18552624)
2008
21
Association of the functional serotonin transporter promoter polymorphism (5-HTTLPR) with externalizing and internalizing aggressivity and alcohol abuse]. (19331786)
2008
22
Alcohol abuse in sickle cell disease: the Pisces Project. (17882609)
2007
23
Cognitive function in older diabetic subjects with a history of alcohol abuse. (18361128)
2007
24
Increased fibronectin expression in lung in the setting of chronic alcohol abuse. (17374047)
2007
25
Death from seizures induced by chronic alcohol abuse--does it exist? (17383203)
2007
26
Alcohol drinking patterns and prevalence of alcohol-abuse and dependence in the Israel National Health Survey. (18080649)
2007
27
Pneumococcal meningitis in community is frequent after craniocerebral trauma and in alcohol abusers. (18030267)
2007
28
Short-term neuropsychological outcome following uncomplicated mild TBI: effects of day-of-injury intoxication and pre-injury alcohol abuse. (17784807)
2007
29
Prevalence and severity of intimate partner violence and associations with family functioning and alcohol abuse in psychiatric inpatients with suicidal intent. (16426084)
2006
30
Alcohol abuse as a risk factor for ARDS]. (17176845)
2006
31
The role played by a former federal government residential school in a First Nation community's alcohol abuse and impaired driving: results of a talking circle. (17131973)
2006
32
Alcohol abuse and risk behavior among adolescents in larger cities in Bosnia and Herzegovina. (15997674)
2005
33
Alcohol abuse screening in primary care. (15702019)
2005
34
Strategies to study human serum transferrin isoforms using integrated liquid chromatography ICPMS, MALDI-TOF, and ESI-Q-TOF detection: application to chronic alcohol abuse. (16131073)
2005
35
Patterns of alcohol consumption in bipolar patients comorbid for alcohol abuse or dependence. (16026491)
2005
36
Should nurses be randomly tested for alcohol abuse? (16116365)
2005
37
Rhabdomyolysis and acute renal failure after strenuous exercise and alcohol abuse: case report and literature review. (15821814)
2005
38
CUGE: a screening instrument for alcohol abuse and dependence in students. (15289205)
2004
39
Alcohol abuse among patients with and without HIV infection attending public clinics in western Kenya. (15868970)
2004
40
Depression, alcohol abuse, and generational differences in Mazahua women in a rural Mexican village. (15371136)
2004
41
Alcohol use disorders and mood disorders: a National Institute on Alcohol Abuse and Alcoholism perspective. (15556112)
2004
42
The co-occurrence of DSM-IV alcohol abuse in DSM-IV alcohol dependence: results of the National Epidemiologic Survey on Alcohol and Related Conditions on heterogeneity that differ by population subgroup. (15351767)
2004
43
Synthesis of daidzin analogues as potential agents for alcohol abuse. (12927869)
2003
44
Spectral analyses of sleep EEG in depressed offspring of fathers with or without a positive history of alcohol abuse or dependence: a pilot study. (13679113)
2003
45
Rhabdomyolysis, hepatitis and multiple hematological disorders associated with alcohol abuse: a case report. (12939102)
2002
46
Novel and previously reported single-nucleotide polymorphisms in the human 5-HT(1B) receptor gene: no association with cocaine or alcohol abuse or dependence. (11496363)
2001
47
Mean cell volume and gamma-glutamyl transferase are superior to carbohydrate-deficient transferrin and hemoglobin-acetaldehyde adducts in the follow-up of pregnant women with alcohol abuse. (10830762)
2000
48
Effect of apolipoprotein E phenotype on plasma lipids and lipoproteins in alcohol abusers. (9194912)
1997
49
Drinking outcomes of alcohol abusers diagnosed as antisocial personality disorder. (7978086)
1994
50
Intestinal pseudo-obstruction in alcohol abuse: report of two cases. (519478)
1979

Variations for Alcohol Abuse

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Expression for genes affiliated with Alcohol Abuse

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Sources:
2BioGPS, 15Gene Expression Omnibus DataSets
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Expression patterns in normal tissues for genes affiliated with Alcohol Abuse

Search GEO for disease gene expression data for Alcohol Abuse.

Pathways for genes affiliated with Alcohol Abuse

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Sources:
50PathCards, 55Reactome, 30KEGG, 38NCBI BioSystems Database, 60Thomson Reuters, 51PharmGKB
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Pathways related to Alcohol Abuse according to GeneCards/GeneDecks:

(show all 11)
idSuper pathways (with members indented)ScoreTop Affiliating Genes
1
Show member pathways
9.3SLC17A5, TF, ABCB7
2
Show member pathways
mitochondrial L-carnitine shuttle pathway38
Saturated fatty acid biosynthesis60
9.2ALDH2, ADH1C
3
Show member pathways
9.2ADH1C, ALDH2
4
Show member pathways
phenylalanine utilization38
noradrenaline and adrenaline degradation38
phenylalanine degradation IV38
9.2ALDH2, ADH1C
5
Show member pathways
glycolysis38
gluconeogenesis38
Glycolysis and Gluconeogenesis38
9.2ALDH2, ADH1C
6
Show member pathways
9.1CYP2E1, ALDH2
7
Show member pathways
Retinol metabolism60
9.1ALDH2, CYP2E1
8
Show member pathways
acetate conversion to acetyl-CoA38
oxidative ethanol degradation III38
ethanol degradation IV38
9.1ALDH2, CYP2E1
9
Show member pathways
8.7ALDH2, ADH1C, CYP2E1
10
Show member pathways
8.7ALDH2, ADH1C, CYP2E1
11
Show member pathways
7.7ABCB7, CYP2E1, GPT, ADH1C, ALDH2

Compounds for genes affiliated with Alcohol Abuse

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Sources:
45Novoseek, 11DrugBank, 51PharmGKB, 29IUPHAR, 24HMDB, 61Tocris Bioscience, 3BitterDB
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Compounds related to Alcohol Abuse according to GeneCards/GeneDecks:

(show top 50)    (show all 122)
idCompoundScoreTop Affiliating Genes
15-hydroxytryptophol459.8GPT, SLC17A5
2alpha-hydroxybutyrate459.7SLC17A5, GPT
3antipyrine45 1110.6SLC17A5, CYP2E1, TF
4nevirapine45 51 1111.5ABCB7, SLC17A5, GPT
5phosphorus459.5SLC17A5, ABCB7, GPT
6hepaplastin459.5SLC17A5, GPT
7opiate459.5SLC17A5, DRD3, TF
8chlorpromazine29 45 51 1112.5ABCB7, CYP2E1, DRD3
9chloralhydrate459.4ALDH2, CYP2E1
10ribavirin45 51 1111.4TF, SLC17A5, GPT
11vitamin b12459.4SLC17A5, GPT, TF
12nash459.4GPT, CYP2E1, SLC17A5
13sevoflurane51 45 1111.4SLC17A5, GPT, CYP2E1
14uric acid45 2410.4SLC17A5, GPT, ABCB7
15isoniazid45 51 1111.4SLC17A5, GPT, CYP2E1
16isoflurane51 45 1111.3CYP2E1, SLC17A5, GPT
17risperidone45 51 29 61 24 1114.3SLC17A5, DRD3, GPT
18pge1459.3SLC17A5, GPT, TF
19rifampicin45 29 6111.3CYP2E1, SLC17A5, GPT
20ccl445 2910.3SLC17A5, GPT, CYP2E1
21vitamin-e459.3ABCB7, GPT, SLC17A5
22acetaminophen45 3 51 24 1113.2SLC17A5, CYP2E1, GPT
23vinylchloride459.2CYP2E1, ALDH2, SLC17A5
24thyroxine45 2410.1TF, ABCB7, SLC17A5, GPT
25fibrinogen459.1GPT, ABCB7, TF, SLC17A5
26rsai459.1ADH1C, CYP2E1, ALDH2
27ursodeoxycholic acid45 24 1111.1ABCB7, CYP2E1, GPT, SLC17A5
28silymarin459.1ABCB7, CYP2E1, GPT, SLC17A5
29phenobarbital45 29 51 1112.0TF, CYP2E1, SLC17A5, GPT
30cocaine45 1110.0SLC17A5, GPT, TF, DRD3
31clozapine45 29 51 1111.9GPT, DRD3, CYP2E1
32iron45 249.9TF, ABCB7, SLC17A5, GPT
33potassium45 24 1110.9SLC17A5, ABCB7, GPT, DRD3
34nicotine45 29 51 1111.8GPT, SLC17A5, CYP2E1, DRD3
35betacarotene458.8SLC17A5, CYP2E1, TF, ALDH2
36valproic acid45 51 24 1111.7CYP2E1, GPT, SLC17A5
37lactate458.6GPT, SLC17A5, TF, ABCB7, CYP2E1
38sodium45 249.6ABCB7, GPT, SLC17A5, DRD3
39disulfiram45 51 61 1111.6SLC17A5, ALDH2, GPT, CYP2E1
40alpha tocopherol458.5TF, GPT, ALDH2
41glutamine458.4TF, GPT, ALDH2, SLC17A5
42acetaldehyde29 45 2410.3ALDH2, TF, CYP2E1, SLC17A5, ADH1C
43aspartate458.3ALDH2, ABCB7, TF, GPT, SLC17A5
44cholesterol45 29 24 1111.3ABCB7, SLC17A5, TF, ALDH2, GPT
45dopamine45 29 24 1111.3ALDH2, DRD3, TF, CYP2E1
46alanine458.3GPT, ALDH2, SLC17A5, TF, ABCB7
47creatinine457.8SLC17A5, CYP2E1, ALDH2, GPT, TF, ABCB7
48glutamate457.8TF, GPT, DRD3, SLC17A5, ABCB7, ALDH2
49ethanol45 51 24 1110.8SLC17A5, ALDH2, ADH1C, GPT, CYP2E1, ABCB7
50vitamin a45 24 119.7GPT, CYP2E1, TF, SLC17A5, ALDH2, ADH1C

GO Terms for genes affiliated with Alcohol Abuse

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Sources:
16Gene Ontology
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Cellular components related to Alcohol Abuse according to GeneCards/GeneDecks:

idNameGO IDScoreTop Affiliating Genes
1endocytic vesicleGO:0301399.5DRD3, TF

Biological processes related to Alcohol Abuse according to GeneCards/GeneDecks:

idNameGO IDScoreTop Affiliating Genes
1cellular iron ion homeostasisGO:0068799.6TF, ABCB7
2response to ethanolGO:0454719.4DRD3, CYP2E1
3ethanol oxidationGO:0060699.3ALDH2, ADH1C
4transmembrane transportGO:0550859.0SLC17A5, TF, ABCB7
5xenobiotic metabolic processGO:0068058.7CYP2E1, ADH1C, ALDH2
6small molecule metabolic processGO:0442817.8ALDH2, ADH1C, GPT, CYP2E1, ABCB7

Products for genes affiliated with Alcohol Abuse

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  • Antibodies
  • Proteins
  • Lysates
  • Antibodies

Sources for Alcohol Abuse

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4CDC
13ExPASy
14FMA
22GTR
23HGMD
24HMDB
25ICD10
26ICD10 via Orphanet
27ICD9CM
29IUPHAR
30KEGG
35MeSH
36MESH via Orphanet
37MGI
40NCIt
41NDF-RT
44NINDS
45Novoseek
47OMIM
48OMIM via Orphanet
52PubMed
53QIAGEN
59SNOMED-CT via Orphanet
62UMLS
63UMLS via Orphanet