MCID: ALC004
MIFTS: 52

Alcohol Abuse malady

Mental diseases category
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Summaries for Alcohol Abuse

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Wikipedia:65 Alcohol abuse, as described in the DSM-IV, is a psychiatric diagnosis describing the recurring use of... more...

MalaCards based summary: Alcohol Abuse, also known as ethanol abuse, is related to alcohol dependence and hepatitis. An important gene associated with Alcohol Abuse is ABCB7 (ATP-binding cassette, sub-family B (MDR/TAP), member 7), and among its related pathways are Transport of glucose and other sugars, bile salts and organic acids, metal ions and amine compounds and Fatty acid metabolism. The compounds 5-hydroxytryptophol and alpha-hydroxybutyrate have been mentioned in the context of this disorder. Affiliated tissues include liver, brain and testes, and related mouse phenotypes are growth/size/body and homeostasis/metabolism.

Disease Ontology:8 A substance abuse that involves the recurring use of alcoholic beverages despite negative consequences.

Aliases & Classifications for Alcohol Abuse

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Alcohol Abuse, Aliases & Descriptions:

Name: Alcohol Abuse 30 8 44 62
 
Ethanol Abuse 8


Classifications:

Malacards categories (disease lists): (See all malacards categories)
Anatomical: Mental diseases


External Ids:

Disease Ontology8 DOID:1574
NCIt39 C20701
SNOMED-CT57 15167005, 304606004
ICD9CM27 305.00, 305.0
MeSH34 D000437

Related Diseases for Alcohol Abuse

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Diseases in the Alcohol Abuse family:

Alcohol Sensitivity, Acute

Diseases related to Alcohol Abuse via text searches within MalaCards or GeneCards/GeneDecks gene sharing:

(show top 50)    (show all 132)
idRelated DiseaseScoreTop Affiliating Genes
1alcohol dependence31.2TF, ALDH2
2hepatitis30.7ABCB7, CYP2E1, GPT, SLC17A5
3viral hepatitis30.6ABCB7, GPT, SLC17A5
4alcoholic hepatitis30.4GPT, SLC17A5
5hepatitis b30.2SLC17A5, GPT, ABCB7
6leukopenia30.2SLC17A5, GPT, ABCB7
7pancreatitis30.2SLC17A5, ALDH2, ADH1C, CYP2E1
8alcoholic pancreatitis30.1CYP2E1, ADH1C, ALDH2
9substance abuse30.0TF, CYP2E1, ALDH2, DRD3
10hepatitis c30.0ABCB7, TF, CYP2E1, GPT, SLC17A5
11acute pancreatitis29.4ABCB7, GPT, ADH1C, ALDH2, SLC17A5
12obesity29.3ABCB7, CYP2E1, GPT, ALDH2, SLC17A5
13alcoholic liver cirrhosis29.0SLC17A5, ALDH2, ADH1C, GPT, CYP2E1, TF
14liver cirrhosis29.0ABCB7, TF, CYP2E1, GPT, ADH1C, ALDH2
15liver disease10.5
16hepatocellular carcinoma10.4
17schizophrenia10.4
18wernicke-korsakoff syndrome10.4
19bipolar disorder10.4
20brain injury10.4
21traumatic brain injury10.4
22fatty liver disease10.3CYP2E1
23conduct disorder10.3
24personality disorder10.3
25pneumonia10.3
26dengue disease10.3SLC17A5, ABCB7
27pyridoxine deficiency10.2GPT, SLC17A5
28hiv/aids10.2
29pathological gambling10.2
30neuronitis10.2
31eating disorder10.2
32esophagitis10.2
33neuropathy10.2
34madelung disease10.2
35sepsis10.2
36obstructive jaundice10.2SLC17A5, GPT
37acute liver failure10.2SLC17A5, GPT
38choledocholithiasis10.2SLC17A5, GPT
39hellp syndrome10.2GPT, SLC17A5
40scrub typhus10.2SLC17A5, GPT
41hepatic encephalopathy10.2GPT, SLC17A5
42bilirubin metabolic disorder10.2GPT, SLC17A5
43portal hypertension10.2GPT, SLC17A5
44siderosis10.2TF, GPT
45cholangitis10.2GPT, SLC17A5
46splenomegaly10.2SLC17A5, GPT
47non-suppurative otitis media10.1CYP2E1, TF
48autoimmune hepatitis10.1SLC17A5, GPT
49galactosemia10.1ABCB7, GPT, SLC17A5
50cholestasis10.1SLC17A5, GPT, ABCB7

Graphical network of the top 20 diseases related to Alcohol Abuse:



Diseases related to alcohol abuse

Symptoms for Alcohol Abuse

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Drugs & Therapeutics for Alcohol Abuse

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Drug clinical trials:

Search ClinicalTrials for Alcohol Abuse

Search NIH Clinical Center for Alcohol Abuse

Genetic Tests for Alcohol Abuse

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Anatomical Context for Alcohol Abuse

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MalaCards organs/tissues related to Alcohol Abuse:

32
Liver, Brain, Testes, Lung, Heart, Bone, Cortex, Whole blood, Thymus, Breast, Endothelial, Prefrontal cortex, Amygdala

Animal Models for Alcohol Abuse or affiliated genes

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MGI Mouse Phenotypes related to Alcohol Abuse:

36
idDescriptionMGI Source AccessionScoreTop Affiliating Genes
1MP:00053787.5DRD3, ABCB7, TF, SLC17A5, ALDH2, ADH1C
2MP:00053766.9ABCB7, TF, CYP2E1, ADH1C, ALDH2, DRD3
3MP:00107686.7SLC17A5, TF, DRD3, ALDH2, ADH1C, CYP2E1

Publications for Alcohol Abuse

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Articles related to Alcohol Abuse:

(show top 50)    (show all 576)
idTitleAuthorsYear
1
Epigenetic signatures of alcohol abuse and hepatitis infection during human hepatocarcinogenesis. (25294808)
2014
2
2013 reviewers, the american journal of drug and alcohol abuse. (24359510)
2014
3
Alcohol abuse as the strongest risk factor for violent offending in patients with paranoid schizophrenia. (24778102)
2014
4
Examination of genetic variation in GABRA2 with conduct disorder and alcohol abuse and dependence in a longitudinal study. (24687270)
2014
5
Mental Health and Migration: Depression, Alcohol Abuse, and Access to Health Care Among Migrants in Central Asia. (24186359)
2013
6
Cardiovascular morbidity, risk of cancer and alcohol abuse in psoriasis: systematic literature reviews and expert opinion. (23845147)
2013
7
Suicide behavior in parents with alcohol abuse problems and suicide behavior in their offspring-adult offspring and counselor perspectives. (22283687)
2012
8
Patterns of protective factors in an intervention for the prevention of suicide and alcohol abuse with Yup'ik Alaska Native youth. (22931082)
2012
9
Protein biomarkers of alcohol abuse. (22967079)
2012
10
Use of the screening suggested by the National Institute on Alcohol Abuse and Alcoholism and of a newly derived tool for the detection of unhealthy alcohol drinkers among surgical patients. (22152670)
2012
11
A mouse model for adolescent alcohol abuse: stunted growth and effects in brain. (22433022)
2012
12
Adolescent-onset alcohol abuse exacerbates the influence of childhood conduct disorder on late adolescent and early adult antisocial behaviour. (23459369)
2011
13
Central American mothers report family history of depression and alcohol abuse as a predictor of teenage health risk behaviors. (21040088)
2010
14
Parent training with behavioral couples therapy for fathers' alcohol abuse: effects on substance use, parental relationship, parenting, and CPS involvement. (19502478)
2009
15
Strategy for increasing detection rates of drug and alcohol abuse in paediatric emergency departments. (19555445)
2009
16
Suicidal behavior in adolescents with comorbid depression and alcohol abuse. (19461576)
2009
17
Alcohol abuse may lead to depression. (19662693)
2009
18
Correlates of and relationship among lifetime alcohol abuse and alcohol dependence in older community residents in Brazil. (20191090)
2009
19
Biochemical and neurotransmitter changes implicated in alcohol-induced brain damage in chronic or 'binge drinking' alcohol abuse. (19155229)
2009
20
Alcohol abuse in adolescents. (18305075)
2008
21
Pilot study of interpersonal psychotherapy versus supportive psychotherapy for dysthymic patients with secondary alcohol abuse or dependence. (18552624)
2008
22
Association of the functional serotonin transporter promoter polymorphism (5-HTTLPR) with externalizing and internalizing aggressivity and alcohol abuse]. (19331786)
2008
23
Alcohol abuse in sickle cell disease: the Pisces Project. (17882609)
2007
24
Cognitive function in older diabetic subjects with a history of alcohol abuse. (18361128)
2007
25
Increased fibronectin expression in lung in the setting of chronic alcohol abuse. (17374047)
2007
26
Death from seizures induced by chronic alcohol abuse--does it exist? (17383203)
2007
27
Alcohol drinking patterns and prevalence of alcohol-abuse and dependence in the Israel National Health Survey. (18080649)
2007
28
Pneumococcal meningitis in community is frequent after craniocerebral trauma and in alcohol abusers. (18030267)
2007
29
Short-term neuropsychological outcome following uncomplicated mild TBI: effects of day-of-injury intoxication and pre-injury alcohol abuse. (17784807)
2007
30
Prevalence and severity of intimate partner violence and associations with family functioning and alcohol abuse in psychiatric inpatients with suicidal intent. (16426084)
2006
31
Alcohol abuse as a risk factor for ARDS]. (17176845)
2006
32
The role played by a former federal government residential school in a First Nation community's alcohol abuse and impaired driving: results of a talking circle. (17131973)
2006
33
Alcohol abuse and risk behavior among adolescents in larger cities in Bosnia and Herzegovina. (15997674)
2005
34
Alcohol abuse screening in primary care. (15702019)
2005
35
Strategies to study human serum transferrin isoforms using integrated liquid chromatography ICPMS, MALDI-TOF, and ESI-Q-TOF detection: application to chronic alcohol abuse. (16131073)
2005
36
Patterns of alcohol consumption in bipolar patients comorbid for alcohol abuse or dependence. (16026491)
2005
37
Should nurses be randomly tested for alcohol abuse? (16116365)
2005
38
CUGE: a screening instrument for alcohol abuse and dependence in students. (15289205)
2004
39
Alcohol abuse among patients with and without HIV infection attending public clinics in western Kenya. (15868970)
2004
40
Depression, alcohol abuse, and generational differences in Mazahua women in a rural Mexican village. (15371136)
2004
41
Alcohol use disorders and mood disorders: a National Institute on Alcohol Abuse and Alcoholism perspective. (15556112)
2004
42
The co-occurrence of DSM-IV alcohol abuse in DSM-IV alcohol dependence: results of the National Epidemiologic Survey on Alcohol and Related Conditions on heterogeneity that differ by population subgroup. (15351767)
2004
43
Synthesis of daidzin analogues as potential agents for alcohol abuse. (12927869)
2003
44
Spectral analyses of sleep EEG in depressed offspring of fathers with or without a positive history of alcohol abuse or dependence: a pilot study. (13679113)
2003
45
Rhabdomyolysis, hepatitis and multiple hematological disorders associated with alcohol abuse: a case report. (12939102)
2002
46
Novel and previously reported single-nucleotide polymorphisms in the human 5-HT(1B) receptor gene: no association with cocaine or alcohol abuse or dependence. (11496363)
2001
47
Mean cell volume and gamma-glutamyl transferase are superior to carbohydrate-deficient transferrin and hemoglobin-acetaldehyde adducts in the follow-up of pregnant women with alcohol abuse. (10830762)
2000
48
Effect of apolipoprotein E phenotype on plasma lipids and lipoproteins in alcohol abusers. (9194912)
1997
49
Drinking outcomes of alcohol abusers diagnosed as antisocial personality disorder. (7978086)
1994
50
Intestinal pseudo-obstruction in alcohol abuse: report of two cases. (519478)
1979

Variations for Alcohol Abuse

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Expression for genes affiliated with Alcohol Abuse

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Expression patterns in normal tissues for genes affiliated with Alcohol Abuse

Search GEO for disease gene expression data for Alcohol Abuse.

Pathways for genes affiliated with Alcohol Abuse

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Pathways related to Alcohol Abuse according to GeneCards/GeneDecks:

(show all 11)
idSuper pathways (with members indented)ScoreTop Affiliating Genes
1
Show member pathways
9.3SLC17A5, TF, ABCB7
2
Show member pathways
mitochondrial L-carnitine shuttle pathway37
Saturated fatty acid biosynthesis60
9.2ALDH2, ADH1C
3
Show member pathways
9.2ADH1C, ALDH2
4
Show member pathways
phenylalanine utilization37
noradrenaline and adrenaline degradation37
phenylalanine degradation IV37
9.2ALDH2, ADH1C
5
Show member pathways
glycolysis37
gluconeogenesis37
Glycolysis and Gluconeogenesis37
9.2ADH1C, ALDH2
6
Show member pathways
9.1ALDH2, CYP2E1
7
Show member pathways
Retinol metabolism60
9.1CYP2E1, ALDH2
8
Show member pathways
acetate conversion to acetyl-CoA37
oxidative ethanol degradation III37
ethanol degradation IV37
9.1CYP2E1, ALDH2
9
Show member pathways
8.7CYP2E1, ADH1C, ALDH2
10
Show member pathways
8.7ALDH2, ADH1C, CYP2E1
11
Show member pathways
7.7ABCB7, CYP2E1, GPT, ADH1C, ALDH2

Compounds for genes affiliated with Alcohol Abuse

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Compounds related to Alcohol Abuse according to GeneCards/GeneDecks:

(show top 50)    (show all 122)
idCompoundScoreTop Affiliating Genes
15-hydroxytryptophol449.8SLC17A5, GPT
2alpha-hydroxybutyrate449.7GPT, SLC17A5
3antipyrine44 1110.6TF, CYP2E1, SLC17A5
4nevirapine44 50 1111.5ABCB7, GPT, SLC17A5
5phosphorus449.5ABCB7, GPT, SLC17A5
6hepaplastin449.5GPT, SLC17A5
7opiate449.5TF, DRD3, SLC17A5
8chlorpromazine28 44 50 1112.5DRD3, CYP2E1, ABCB7
9chloralhydrate449.4ALDH2, CYP2E1
10ribavirin44 50 1111.4TF, GPT, SLC17A5
11vitamin b12449.4TF, GPT, SLC17A5
12nash449.4SLC17A5, GPT, CYP2E1
13sevoflurane50 44 1111.4SLC17A5, GPT, CYP2E1
14uric acid44 2410.4SLC17A5, GPT, ABCB7
15isoniazid44 50 1111.4SLC17A5, GPT, CYP2E1
16isoflurane50 44 1111.3SLC17A5, GPT, CYP2E1
17risperidone44 50 28 61 24 1114.3SLC17A5, DRD3, GPT
18pge1449.3TF, GPT, SLC17A5
19rifampicin44 28 6111.3SLC17A5, GPT, CYP2E1
20ccl444 2810.3SLC17A5, GPT, CYP2E1
21vitamin-e449.3SLC17A5, GPT, ABCB7
22acetaminophen44 2 50 24 1113.2SLC17A5, GPT, CYP2E1
23vinylchloride449.2CYP2E1, ALDH2, SLC17A5
24thyroxine44 2410.1ABCB7, TF, GPT, SLC17A5
25fibrinogen449.1ABCB7, TF, GPT, SLC17A5
26rsai449.1CYP2E1, ADH1C, ALDH2
27ursodeoxycholic acid44 24 1111.1ABCB7, CYP2E1, GPT, SLC17A5
28silymarin449.1ABCB7, CYP2E1, GPT, SLC17A5
29phenobarbital44 28 50 1112.0SLC17A5, GPT, CYP2E1, TF
30cocaine44 1110.0TF, GPT, DRD3, SLC17A5
31clozapine44 28 50 1111.9CYP2E1, GPT, DRD3
32iron44 249.9ABCB7, TF, GPT, SLC17A5
33potassium44 24 1110.9SLC17A5, DRD3, GPT, ABCB7
34valproic acid44 50 24 1111.9CYP2E1, GPT, SLC17A5
35nicotine44 28 50 1111.8CYP2E1, GPT, DRD3, SLC17A5
36betacarotene448.8SLC17A5, ALDH2, CYP2E1, TF
37lactate448.6ABCB7, TF, CYP2E1, GPT, SLC17A5
38sodium44 249.6SLC17A5, DRD3, GPT, ABCB7
39disulfiram44 50 61 1111.6CYP2E1, GPT, ALDH2, SLC17A5
40glutamine448.4TF, GPT, ALDH2, SLC17A5
41acetaldehyde28 44 2410.3SLC17A5, ALDH2, ADH1C, CYP2E1, TF
42alpha tocopherol448.3TF, GPT, ALDH2
43aspartate448.3ABCB7, TF, GPT, ALDH2, SLC17A5
44cholesterol44 28 24 1111.3ABCB7, TF, GPT, ALDH2, SLC17A5
45dopamine44 28 24 1111.3DRD3, ALDH2, CYP2E1, TF
46alanine448.3ABCB7, TF, GPT, ALDH2, SLC17A5
47creatinine447.8ABCB7, TF, CYP2E1, GPT, ALDH2, SLC17A5
48glutamate447.8ABCB7, TF, GPT, ALDH2, DRD3, SLC17A5
49ethanol44 50 24 1110.8ABCB7, CYP2E1, GPT, ADH1C, ALDH2, SLC17A5
50vitamin a44 24 119.7TF, CYP2E1, GPT, ADH1C, ALDH2, SLC17A5

GO Terms for genes affiliated with Alcohol Abuse

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Cellular components related to Alcohol Abuse according to GeneCards/GeneDecks:

idNameGO IDScoreTop Affiliating Genes
1endocytic vesicleGO:0301399.5DRD3, TF

Biological processes related to Alcohol Abuse according to GeneCards/GeneDecks:

idNameGO IDScoreTop Affiliating Genes
1cellular iron ion homeostasisGO:0068799.6ABCB7, TF
2response to ethanolGO:0454719.4DRD3, CYP2E1
3ethanol oxidationGO:0060699.3ALDH2, ADH1C
4transmembrane transportGO:0550859.0SLC17A5, TF, ABCB7
5xenobiotic metabolic processGO:0068058.7CYP2E1, ADH1C, ALDH2
6small molecule metabolic processGO:0442817.8ADH1C, ABCB7, CYP2E1, GPT, ALDH2

Products for genes affiliated with Alcohol Abuse

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  • Antibodies
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  • Lysates

Sources for Alcohol Abuse

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3CDC
13ExPASy
14FMA
22GTR
23HGMD
24HMDB
25ICD10
26ICD10 via Orphanet
27ICD9CM
28IUPHAR
29KEGG
34MeSH
35MESH via Orphanet
36MGI
39NCIt
40NDF-RT
43NINDS
44Novoseek
46OMIM
47OMIM via Orphanet
51PubMed
52QIAGEN
58SNOMED-CT via Orphanet
62UMLS
63UMLS via Orphanet