MCID: ALC004
MIFTS: 57

Alcohol Abuse

Categories: Mental diseases, Genetic diseases, Rare diseases

Aliases & Classifications for Alcohol Abuse

MalaCards integrated aliases for Alcohol Abuse:

Name: Alcohol Abuse 38 12 52 14 69
Alcohol-Related Disorders 42 69
Alcoholic Intoxication, Chronic 69
Ethanol Abuse 12
Alcoholism 42

Classifications:



External Ids:

Disease Ontology 12 DOID:1574
ICD10 33 F10.1
ICD9CM 35 305.0 305.00
NCIt 47 C20701
SNOMED-CT 64 15167005 304606004
UMLS 69 C0085762

Summaries for Alcohol Abuse

Disease Ontology : 12 A substance abuse that involves the recurring use of alcoholic beverages despite negative consequences.

MalaCards based summary : Alcohol Abuse, also known as alcohol-related disorders, is related to antisocial personality disorder and personality disorder, and has symptoms including hangover from any alcohol or other drugs substance and hangover from alcohol. An important gene associated with Alcohol Abuse is CYP2E1 (Cytochrome P450 Family 2 Subfamily E Member 1), and among its related pathways/superpathways are Porphyrin and chlorophyll metabolism and Monoamine GPCRs. The drugs Bupropion and Dopamine have been mentioned in the context of this disorder. Affiliated tissues include brain, liver and testes, and related phenotypes are Decreased shRNA abundance and homeostasis/metabolism

Wikipedia : 72 Alcohol abuse is a previous psychiatric diagnosis in which there is recurring harmful use of alcohol... more...

Related Diseases for Alcohol Abuse

Diseases in the Alcohol Abuse family:

Alcohol Sensitivity, Acute

Diseases related to Alcohol Abuse via text searches within MalaCards or GeneCards Suite gene sharing:

(show top 50) (show all 174)
id Related Disease Score Top Affiliating Genes
1 antisocial personality disorder 28.7 ANKK1 DRD2 DRD3 DRD4
2 personality disorder 28.2 ALDH2 BDNF CNR1 DRD2 DRD3 DRD4
3 schizophrenia 28.0 BDNF CNR1 DRD2 DRD3 DRD4 PRL
4 alcoholic liver cirrhosis 21.0 ABCB7 AKR1A1 ALDH2 ALDH9A1 ANKK1 BDNF
5 alcohol dependence 11.2
6 wernicke-korsakoff syndrome 11.2
7 cerebellar degeneration 11.0
8 nonalcoholic steatohepatitis 10.9
9 atrial fibrillation and stroke 10.9
10 cerebral beriberi 10.9
11 dystonia-11, myoclonic 10.9
12 osteonecrosis 10.9
13 hyperchylomicronemia, late-onset 10.9
14 birth defects 10.9
15 hypersomnia 10.9
16 korsakoff's amnesic syndrome 10.9
17 tremor 10.9
18 lipomatosis, multiple symmetric 10.9
19 nuchal bleb, familial 10.9
20 beriberi 10.9
21 megalocytic interstitial nephritis 10.9
22 htra1-related autosomal dominant cerebral small vessel disease 10.8 GPT SLC17A5
23 quinquaud's decalvans folliculitis 10.7 GPT SLC17A5
24 female infertility of uterine origin 10.7 GPT SLC17A5 TF
25 microcephaly 8, primary, autosomal recessive 10.6 GPT SLC17A5 TF
26 paranasal sinus sarcoma 10.6 GGT1 GPT SLC17A5
27 lethal hydranencephaly-diaphragmatic hernia syndrome 10.6 AKR1A1 CYP2E1
28 nonsyndromic hereditary sensorineural hearing loss 10.5 CYP2E1 GPT SLC17A5
29 c8 deficiency, type ii 10.5 DRD2 DRD4 FAAH
30 spinocerebellar ataxia 8 10.5 DRD2 GPT TF
31 alopecia 10.5 CYP2E1 GPT SLC17A5
32 intracranial cavernous angioma 10.5 DRD2 SLC6A4
33 hemorrhagic cystitis 10.5 DRD2 DRD4 SLC6A4
34 autoimmune inner ear disease 10.5 CNR1 FAAH
35 noninfectious dermatoses of eyelid 10.4 ABCB7 GGT1 GPT SLC17A5
36 dissociative disorder 10.4 DRD3 SLC6A4
37 postencephalitic parkinson disease 10.4 BDNF DRD2 SLC6A4
38 orbit lymphoma 10.4 CNR1 FAAH
39 pancreatic cystadenocarcinoma 10.4 GGT1 GPT
40 placenta disease 10.4 DRD2 DRD3 DRD4
41 suppurative periapical periodontitis 10.3 DRD2 DRD3 SLC6A4
42 alpha 1-antitrypsin deficiency 10.3 ALDH2 CYP2E1 SLC17A5 TF
43 funisitis 10.3 AKR1A1 ALDH9A1 BDNF
44 osteogenesis imperfecta, type ix 10.2 BDNF DRD2 DRD4
45 hepatitis d 10.2 BDNF DRD2 DRD4 SLC6A4
46 partial motor epilepsy 10.2 BDNF DRD2 DRD4 SLC6A4
47 carotid stenosis 10.2 ALDH2 DRD2 DRD4 SLC6A4
48 rhinoscleroma 10.2 DRD2 PRL
49 ornithosis 10.2 DRD2 PRL SLC6A4
50 hepatitis 10.1

Comorbidity relations with Alcohol Abuse via Phenotypic Disease Network (PDN): (show all 19)


Active Peptic Ulcer Disease Acute Cystitis
Acute Pancreatitis Alcohol-Induced Mental Disorder
Alcoholic Cardiomyopathy Alcoholic Gastritis
Alcoholic Hepatitis Alcoholic Liver Cirrhosis
Alcoholic Neuropathy Cocaine Abuse
Deficiency Anemia Familial Atrial Fibrillation
Fatty Liver Disease Hepatic Encephalopathy
Hypertension, Essential Pancreatitis, Hereditary
Protein-Energy Malnutrition Respiratory Failure
Schizophreniform Disorder

Graphical network of the top 20 diseases related to Alcohol Abuse:



Diseases related to Alcohol Abuse

Symptoms & Phenotypes for Alcohol Abuse

UMLS symptoms related to Alcohol Abuse:


hangover from any alcohol or other drugs substance, hangover from alcohol

GenomeRNAi Phenotypes related to Alcohol Abuse according to GeneCards Suite gene sharing:

26
id Description GenomeRNAi Source Accession Score Top Affiliating Genes
1 Decreased shRNA abundance GR00251-A-1 9.28 ALDH9A1 CYP2E1
2 Decreased shRNA abundance GR00251-A-2 9.28 ALDH9A1 CYP2E1
3 Decreased shRNA abundance GR00297-A 9.28 ABCB7 AKR1A1 ALDH9A1 CYP2E1 GABRA2
4 Decreased melanin production GR00056-A 9.13 ALDH9A1 SLC17A5 UROD

MGI Mouse Phenotypes related to Alcohol Abuse:

44
id Description MGI Source Accession Score Top Affiliating Genes
1 homeostasis/metabolism MP:0005376 10.19 ABCB7 AKR1A1 ALDH2 BDNF CNR1 CYP2E1
2 behavior/neurological MP:0005386 10.13 ALDH2 BDNF CNR1 CYP2E1 DRD2 DRD3
3 integument MP:0010771 9.85 ALDH2 ALDH9A1 BDNF CNR1 DRD2 FAAH
4 mortality/aging MP:0010768 9.83 ABCB7 AKR1A1 ALDH2 BDNF CNR1 CYP2E1
5 nervous system MP:0003631 9.4 ALDH2 BDNF CNR1 DRD2 DRD3 DRD4

Drugs & Therapeutics for Alcohol Abuse

Drugs for Alcohol Abuse (from DrugBank, HMDB, Dgidb, PharmGKB, IUPHAR, NovoSeek, BitterDB):

(show top 50) (show all 372)
id Name Status Phase Clinical Trials Cas Number PubChem Id
1
Bupropion Approved Phase 4,Phase 3,Phase 1,Phase 2 34841-39-9, 34911-55-2 444
2
Dopamine Approved Phase 4,Phase 3,Phase 2,Phase 1,Early Phase 1 51-61-6, 62-31-7 681
3
Ethanol Approved Phase 4,Phase 3,Phase 2,Phase 1,Early Phase 1 64-17-5 702
4
Fluoxetine Approved, Vet_approved Phase 4,Phase 2 54910-89-3 3386
5
Acamprosate Approved, Investigational Phase 4,Phase 3,Phase 2 77337-76-9 71158
6
Acetaminophen Approved Phase 4 103-90-2 1983
7
Clonidine Approved Phase 4 4205-90-7 2803
8
Ropivacaine Approved Phase 4 84057-95-4 71273 175805
9
Sufentanil Approved, Investigational Phase 4 56030-54-7 41693
10
Tramadol Approved, Investigational Phase 4 27203-92-5 33741
11
Lamotrigine Approved, Investigational Phase 4 84057-84-1 3878
12
Naltrexone Approved, Investigational, Vet_approved Phase 4,Phase 3,Phase 2,Phase 1,Early Phase 1 16590-41-3 5360515
13
Topiramate Approved Phase 4,Phase 2,Phase 3 97240-79-4 5284627
14
Disulfiram Approved Phase 4,Phase 2,Phase 1 97-77-8 3117
15
Buprenorphine Approved, Illicit, Investigational, Vet_approved Phase 4,Phase 2 52485-79-7 40400 644073
16
Guaifenesin Approved, Vet_approved Phase 4 93-14-1 3516
17
Methadone Approved Phase 4,Phase 2 76-99-3 4095
18
Amphetamine Approved, Illicit Phase 4 300-62-9 5826 3007
19
Cocaine Approved, Illicit Phase 4,Phase 2,Phase 3,Phase 1,Early Phase 1 50-36-2 5760 446220
20
Ondansetron Approved Phase 4,Phase 3,Phase 2,Phase 1 99614-02-5 4595
21
Citalopram Approved Phase 4,Phase 2 59729-33-8 2771
22
Chlorzoxazone Approved Phase 4 95-25-0 2733
23
Methylphenidate Approved, Investigational Phase 4,Early Phase 1 113-45-1 4158
24
Varenicline Approved, Investigational Phase 4,Phase 2,Phase 3,Phase 1,Early Phase 1 249296-44-4 5310966
25
Dutasteride Approved, Investigational Phase 4 164656-23-9 152945 6918296
26
Zonisamide Approved, Investigational Phase 4,Phase 3,Phase 2 68291-97-4 5734
27
Benzocaine Approved Phase 4,Phase 3,Phase 1,Phase 2 1994-09-7, 94-09-7 2337
28
Paroxetine Approved, Investigational Phase 4 61869-08-7 43815
29
Haloperidol Approved Phase 4 52-86-8 3559
30
Lorazepam Approved Phase 4,Phase 2 846-49-1 3958
31
Ribavirin Approved Phase 4,Phase 2 36791-04-5 37542
32
Risperidone Approved, Investigational Phase 4 106266-06-2 5073
33
Carbamazepine Approved, Investigational Phase 4 298-46-4 2554
34
Nicotine Approved Phase 4,Phase 3,Phase 2,Phase 1,Early Phase 1 54-11-5 942 89594
35
Sertraline Approved Phase 4,Phase 2,Phase 1 79617-96-2 68617
36
Naloxone Approved, Vet_approved Phase 4,Phase 3 465-65-6 5284596
37
Oxytocin Approved, Vet_approved Phase 4,Phase 2,Phase 1 50-56-6 439302 53477758
38
Aripiprazole Approved, Investigational Phase 4,Phase 2,Phase 3 129722-12-9 60795
39
Valproic Acid Approved, Investigational Phase 4,Phase 2 99-66-1 3121
40
Gabapentin Approved, Investigational Phase 4,Phase 3,Phase 2 60142-96-3 3446
41
Olanzapine Approved, Investigational Phase 4,Phase 2 132539-06-1 4585
42
Clozapine Approved Phase 4 5786-21-0 2818
43
Heroin Approved, Illicit Phase 4 561-27-3 5462328
44 tannic acid Approved, Nutraceutical Phase 4,Phase 3,Phase 1,Phase 2
45
Choline Approved, Nutraceutical Phase 4,Phase 1,Phase 2 62-49-7 305
46
Glutamic Acid Approved, Nutraceutical Phase 4,Phase 2 56-86-0 33032
47 Nefopam Investigational Phase 4 13669-70-0
48
gamma-Aminobutyric acid Investigational Phase 4,Phase 3,Phase 2 56-12-2 119
49 Antidepressive Agents Phase 4,Phase 2,Phase 3,Phase 1,Early Phase 1
50 Antidepressive Agents, Second-Generation Phase 4,Phase 2,Phase 3,Phase 1

Interventional clinical trials:

(show top 50) (show all 824)

id Name Status NCT ID Phase Drugs
1 Fluoxetine and Bupropion to Treat Patients With Depression and Alcoholism Unknown status NCT00449007 Phase 4 fluoxetine;bupropion
2 Safety of Acamprosate for Alcohol Dependence in the Elderly: An Open-Label Study (SAFADIE) Unknown status NCT00655967 Phase 4 Acamprosate (Campral);Acamprosate
3 Epidural Analgesia for Pancreatitis (Epipan Study) Unknown status NCT02126332 Phase 4
4 Treatment of Alcohol Dependence and Comorbid Bipolar Disorder Unknown status NCT01015586 Phase 4 Lamotrigine;Placebo
5 Atomoxetine Treatment of Adults With ADHD and Comorbid Alcohol Abuse Completed NCT00190957 Phase 4 Atomoxetine;placebo
6 Quetiapine in Patients With Bipolar and Alcohol Abuse/Dependence Completed NCT00223249 Phase 4 Quetiapine
7 STAR*D Alcohol: Treatment of Depression Concurrent With Alcohol Abuse Completed NCT00369746 Phase 4 citalopram
8 Naltrexone Treatment of Alcohol Abuse in Schizophrenia Completed NCT00145847 Phase 4 Naltrexone or Placebo
9 Acamprosate Added to Escitalopram and Behavioral Treatment for Comorbid Depression and Alcoholism Completed NCT00452543 Phase 4 acamprosate;escitalopram;Placebo
10 Placebo-Controlled Cross Over Trial of Chlorzoxazone Intake Completed NCT01342341 Phase 4 Parafon Forte
11 Adolescent Family-Based Alcohol Prevention Completed NCT00858065 Phase 4
12 Efficacy and Tolerability of Topiramate in Treatment of Bipolar Mania and Alcohol Use in Adolescents and Young Adults Completed NCT00550394 Phase 4 quetiapine and placebo;Quetiapine and Topiramate
13 Treatment of Patients With Alcoholism and Attention Deficit Disorder Completed NCT00261872 Phase 4 Methylphenidate
14 Bupropion as a Smoking Cessation Aid in Alcoholics Completed NCT00044434 Phase 4 bupropion (Wellbutrin)
15 Varenicline in Drug Treatment Completed NCT01286584 Phase 4 varenicline;placebo
16 Dutasteride for the Reduction of Alcohol Use in Male Drinkers Completed NCT01262287 Phase 4 Dutasteride;Placebo
17 Zonisamide vs. Placebo in the Treatment of Alcohol Dependence Completed NCT00595556 Phase 4 zonisamide;Placebo
18 Topiramate Treatment of Alcohol Use Disorders in Veterans With Post Traumatic Stress Disorder (PTSD): A Pilot Controlled Trial of Augmentation Therapy Completed NCT01087736 Phase 4 Topiramate
19 Citicoline for Alcohol Dependence Completed NCT02074735 Phase 4 Placebo;Citicoline
20 AID-trial Assertive Intervention After Deliberate Self-harm Completed NCT00700089 Phase 4
21 Naltrexone for Bipolar Disorder and Alcohol Dependence Completed NCT00223275 Phase 4 Naltrexone
22 Paroxetine for Comorbid Social Anxiety Disorder and Alcoholism Completed NCT00246441 Phase 4 Paroxetine;Placebo
23 A Comparison Study of the Efficacy of Quetiapine and Haloperidol in Agitated Adults in Emergency Room Completed NCT00457366 Phase 4 Quetiapine;Cocktail (Haloperidol, Lorazepam, Cogentin)
24 Prospective Anti-Hepatitis C Virus (Anti-HCV) Trial of Peg-Interferon and Ribavirin in Subjects of First Nations, Metis and Caucasian Ethnicity Completed NCT00957866 Phase 4 Pegylated Interferons (Peg-IFN) and Ribavirin
25 Paroxetine - Controlled Release in the Treatment of Irritable Bowel Syndrome (IBS) Completed NCT00610909 Phase 4 Paroxetine CR;Placebo
26 Letigen® and Cardiovascular Morbidity Completed NCT00692666 Phase 4
27 The Effects of a Parental Intervention on Electronic Media Exposure and Sleep Patterns in Adolescents Completed NCT02365025 Phase 4
28 Efficacy of Quetiapine in the Treatment of Patients With Schizophrenia and a Comorbid Substance Use Disorder Completed NCT00156715 Phase 4 Quetiapine
29 Use of Naltrexone in a Clinical Setting Completed NCT00000445 Phase 4 naltrexone (Revia)
30 Risperidone Long-acting Versus Oral Risperidone in Patients With Schizophrenia and Alcohol Use Disorder Completed NCT00130923 Phase 4 Risperidone Long Acting;oral risperidone
31 Drug Therapy for Alcohol Detoxification Completed NCT00000441 Phase 4 lorazepam (Ativan);carbamazepine (Tegretol)
32 Naltrexone Treatment of Alcohol Dependence Completed NCT00000452 Phase 4 naltrexone (Revia)
33 Drug Treatment for Depressed Alcoholics (Naltrexone/Fluoxetine) Completed NCT00006204 Phase 4 naltrexone (Revia);fluoxetine (Prozac)
34 Naltrexone, Craving, and Drinking Completed NCT00006203 Phase 4 naltrexone (Revia)
35 Behavior and Naltrexone Treatment for Alcoholics Completed NCT00000449 Phase 4 naltrexone (Revia)
36 Adjunctive Topiramate for Treatment of Alcohol Dependence in Patients With Bipolar Disorder Completed NCT00572117 Phase 4 Topiramate
37 The Whole Day First Grade Program Completed NCT00257088 Phase 4
38 Disulfiram Combined With Lorazepam for Alcohol Dependence and Anxiety Disorder Completed NCT00721526 Phase 4 disulfiram plus lorazepam
39 The Effects of Topiramate on Alcohol Use in Alcohol Dependent Subjects Completed NCT00329407 Phase 4 Topiramate (Topamax)
40 Naltrexone for Heavy Drinking in Young Adults Completed NCT00568958 Phase 4 naltrexone;placebo naltrexone
41 Smoking Cessation in Alcoholism Treatment Completed NCT00000454 Phase 4 nicotine replacement patch
42 Genetic and Brain Mechanisms of Naltrexone's Treatment Efficacy for Alcoholism Completed NCT00920829 Phase 4 Drug;Placebo
43 Treatment of Alcohol Withdrawal in Hospital Patients Completed NCT00249366 Phase 4 Lorazepam (drug);Lorazepam
44 Pharmacogenetic Response to Naltrexone For Alcohol Dependence Completed NCT00831272 Phase 4 naltrexone;Placebo
45 Naltrexone Treatment for Alcoholic Women Completed NCT00000448 Phase 4 naltrexone;Placebo
46 Timing of Smoking Intervention in Alcohol Treatment (Nicotine Patch) Completed NCT00000444 Phase 4 nicotine replacement patch
47 Behavioral Counseling for Alcohol Dependent Smokers (Nicotine Patch) Completed NCT00004551 Phase 4 nicotine replacement patch
48 Behavioral/Drug Therapy for Alcohol-Nicotine Dependence (Naltrexone/Nicotine Patch) Completed NCT00000447 Phase 4 naltrexone (Revia);nicotine replacement patch
49 Combination Nicotine Replacement for Alcoholic Smokers Completed NCT00064844 Phase 4
50 Treatment for Alcoholism and Post-Traumatic Stress Disorder (Naltrexone) Completed NCT00006489 Phase 4 Naltrexone;Placebo

Search NIH Clinical Center for Alcohol Abuse

Inferred drug relations via UMLS 69 / NDF-RT 48 :


Cochrane evidence based reviews: alcoholism

Genetic Tests for Alcohol Abuse

Anatomical Context for Alcohol Abuse

MalaCards organs/tissues related to Alcohol Abuse:

39
Brain, Liver, Testes, Lung, Bone, Heart, Breast

Publications for Alcohol Abuse

Articles related to Alcohol Abuse:

(show top 50) (show all 695)
id Title Authors Year
1
Genetic divergence in the transcriptional engram of chronic alcohol abuse: A laser-capture RNA-seq study of the mouse mesocorticolimbic system. ( 27894806 )
2017
2
Solid-phase extraction of the alcohol abuse biomarker phosphatidylethanol using newly synthesized polymeric sorbent materials containing quaternary heterocyclic groups. ( 28890270 )
2017
3
Theoretical Foundations of Appeals Used in Alcohol-Abuse and Drunk-Driving Public Service Announcements in the United States, 1995-2010. ( 28511551 )
2017
4
Correction: Experiences of severe childhood maltreatment, depression, anxiety and alcohol abuse among adults in Finland. ( 28640921 )
2017
5
Traumatic Brain Injuries during Development: Implications for Alcohol Abuse. ( 28775682 )
2017
6
Sporadic Porphyria Cutanea Tarda Induced by Alcohol Abuse. ( 28776562 )
2017
7
Chronic alcohol abuse in men alters bone mechanical properties by affecting both tissue mechanical properties and microarchitectural parameters. ( 28410916 )
2017
8
Alcohol Abuse and Cardiac Disease. ( 28057245 )
2017
9
Burden of Alcohol Abuse or Dependence Among Long-Term Opioid Users with Chronic Noncancer Pain. ( 28650247 )
2017
10
Re-evaluation of the reward comparison hypothesis for alcohol abuse. ( 28606627 )
2017
11
Contextual Factors Related to Alcohol Abuse Among Intimate Partner Violence Offenders. ( 27759488 )
2017
12
Mood disorder, anxiety, and suicide risk among subjects with alcohol abuse and/or dependence: a population-based study. ( 28658442 )
2017
13
Alcohol Abuse is Associated with Enhanced Pulmonary and Systemic Xanthine Oxidoreductase Activity. ( 28839105 )
2017
14
The association between alcohol abuse and neuroendocrine system dysregulation: Race differences in a National sample. ( 28751021 )
2017
15
Chronic Alcohol Abuse Leads to Low Bone Mass with No General Loss of Bone Structure or Bone Mechanical Strength(). ( 27864963 )
2017
16
Drinking Status Between Ages 50 and 55 for Men From the San Diego Prospective Study Who Developed DSM-IV Alcohol Abuse or Dependence in Prior Follow-Ups. ( 28728633 )
2017
17
Seasonal affective disorder and alcohol abuse disorder in a population-based study. ( 28364591 )
2017
18
College Students' Responses to Emotional Anti-Alcohol Abuse Media Messages: Should We Scare or Amuse Them? ( 28705030 )
2017
19
Association of Physical Activity with Alcohol Abuse and Dependence in a Nationally-Representative U.S. Sample. ( 28704120 )
2017
20
Experiences of severe childhood maltreatment, depression, anxiety and alcohol abuse among adults in Finland. ( 28481912 )
2017
21
The effects of seasonal affective disorder and alcohol abuse on sleep and snoring functions in a population-based study in Finland. ( 28901656 )
2017
22
The effects of residential dual diagnosis treatment on alcohol abuse. ( 28868159 )
2017
23
Gender Differences in Suicidal Behaviors: Mediation Role of Psychological Distress Between Alcohol Abuse/Dependence and Suicidal Behaviors. ( 28805555 )
2017
24
Randomized Trial of Motivational Interviewing Plus Feedback for Soldiers With Untreated Alcohol Abuse. ( 27736113 )
2016
25
Physiological processes underlying organ injury in alcohol abuse. ( 27436613 )
2016
26
Alcohol abuse after traumatic brain injury: Experimental and clinical evidence. ( 26814960 )
2016
27
When a liver transplant recipient goes back to alcohol abuse: Should we be more selective? ( 27239105 )
2016
28
The influences of parental divorce and maternal-versus-paternal alcohol abuse on offspring lifetime suicide attempt. ( 27538533 )
2016
29
Chronic alcohol abuse. ( 27903033 )
2016
30
Alcohol abuse increases the risk of HIV infection and diminishes health status of clients attending HIV testing services in Vietnam. ( 26879232 )
2016
31
11I^-hydroxysteroid dehydrogenase inhibition as a new potential therapeutic target for alcohol abuse. ( 26978742 )
2016
32
Cognitive Decline and Recovery in Alcohol Abuse. ( 27460131 )
2016
33
Recent Advances in Nicotinic Receptor Signaling in Alcohol Abuse and Alcoholism. ( 26810002 )
2016
34
Alcohol abuse and other factors associated with risky sexual behaviors among adolescent students from the poorest areas in Costa Rica. ( 27572491 )
2016
35
Informal Control by Family and Risk Markers for Alcohol Abuse/Dependence in Seoul. ( 27161846 )
2016
36
Workplace Discrimination Is Associated With Alcohol Abuse Among Ethnically Diverse Hospital Staff. ( 27034406 )
2016
37
Are therapeutic vaccines an answer to the global problem of drug and alcohol abuse? ( 27721531 )
2016
38
Couples living with and around alcohol abuse: A study of a farmworker community in the Cape Winelands, South Africa. ( 27043369 )
2016
39
Burnout and Alcohol Abuse/Dependence Among U.S. Medical Students. ( 26934693 )
2016
40
Chronic Hepatitis C and Alcohol Abuse: The Single Center Experience of Novi Sad - Serbia. ( 27457344 )
2016
41
Bioinformatic Analysis of DNA Methylation in Neural Progenitor Cell Models of Alcohol Abuse. ( 27774408 )
2016
42
Factors associated with alcohol abuse and dependence among public transport workers in the metropolitan region of Belo Horizonte. ( 27001551 )
2016
43
Acute oesophageal necrosis in a young man with cocaine and alcohol abuse. ( 27881583 )
2016
44
Alcohol abuse and smoking alter inflammatory mediator production by pulmonary and systemic immune cells. ( 26747782 )
2016
45
Glucocorticoid Receptor (NR3C1) Gene Polymorphism Moderate Intervention Effects on the Developmental Trajectory of African-American Adolescent Alcohol Abuse. ( 27817096 )
2016
46
Iudicium: An Educational Intervention for addressing Risk Perception of Alcohol Abuse in Adolescents. ( 26990389 )
2016
47
Alcohol abuse and involvement in traffic accidents in the Brazilian population, 2013. ( 27925118 )
2016
48
Correlates of depression in self-neglecting older adults: A cross-sectional study examining the role of alcohol abuse and pain in increasing vulnerability. ( 26716386 )
2016
49
Negative and interactive effects of sex, aging, and alcohol abuse on gray matter morphometry. ( 26947584 )
2016
50
Serotonin-Related Gene Polymorphisms and Asymptomatic Neurocognitive Impairment in HIV-Infected Alcohol Abusers. ( 27069689 )
2016

Variations for Alcohol Abuse

Expression for Alcohol Abuse

LifeMap Discovery
Genes differentially expressed in tissues of Alcohol Abuse patients vs. healthy controls: 35
id Gene Description Tissue Up/Dn Fold Change (log2) P value
1 ADAMTS18 ADAM metallopeptidase with thrombospondin type 1 motif, 18 Brain - 3.66 0.005
Search GEO for disease gene expression data for Alcohol Abuse.

Pathways for Alcohol Abuse

Pathways related to Alcohol Abuse according to GeneCards Suite gene sharing:

id Super pathways Score Top Affiliating Genes
1
Show member pathways
11.89 AKR1A1 ALDH2 ALDH9A1 UROD
2
Show member pathways
11.6 DRD2 DRD3 DRD4
4 11.51 CNR1 DRD3 DRD4
5
Show member pathways
11.44 DRD2 DRD3 DRD4
6
Show member pathways
11.17 AKR1A1 ALDH2 ALDH9A1 CYP2E1

GO Terms for Alcohol Abuse

Cellular components related to Alcohol Abuse according to GeneCards Suite gene sharing:

id Name GO ID Score Top Affiliating Genes
1 endocytic vesicle GO:0030139 8.8 DRD2 DRD3 TF

Biological processes related to Alcohol Abuse according to GeneCards Suite gene sharing:

(show all 30)
id Name GO ID Score Top Affiliating Genes
1 response to ethanol GO:0045471 9.81 CNR1 CYP2E1 DRD2 DRD3
2 social behavior GO:0035176 9.77 DRD3 DRD4 SLC6A4
3 response to cocaine GO:0042220 9.75 CNR1 DRD2 DRD3
4 negative regulation of adenylate cyclase activity GO:0007194 9.74 DRD2 DRD3 DRD4
5 negative regulation of blood pressure GO:0045776 9.67 CNR1 DRD2 DRD3
6 synaptic transmission, dopaminergic GO:0001963 9.65 DRD2 DRD3
7 response to morphine GO:0043278 9.65 CNR1 DRD2 DRD3
8 behavioral response to ethanol GO:0048149 9.64 DRD2 DRD4
9 neurotransmitter biosynthetic process GO:0042136 9.64 ALDH9A1 SLC6A4
10 negative regulation of voltage-gated calcium channel activity GO:1901386 9.63 DRD2 DRD4
11 prepulse inhibition GO:0060134 9.63 DRD2 DRD3
12 response to amphetamine GO:0001975 9.63 DRD2 DRD3 DRD4
13 positive regulation of renal sodium excretion GO:0035815 9.62 DRD2 DRD3
14 regulation of synaptic transmission, GABAergic GO:0032228 9.62 CNR1 DRD2
15 G-protein coupled receptor internalization GO:0002031 9.61 DRD2 DRD3
16 cellular aldehyde metabolic process GO:0006081 9.61 AKR1A1 ALDH9A1
17 regulation of cAMP metabolic process GO:0030814 9.6 DRD2 DRD3
18 regulation of dopamine uptake involved in synaptic transmission GO:0051584 9.58 DRD2 DRD3
19 arachidonic acid secretion GO:0050482 9.58 DRD2 DRD3 DRD4
20 negative regulation of dopamine secretion GO:0033602 9.56 CNR1 DRD2
21 positive regulation of dopamine uptake involved in synaptic transmission GO:0051586 9.55 DRD2 DRD4
22 negative regulation of dopamine receptor signaling pathway GO:0060160 9.54 DRD2 DRD3
23 behavioral response to cocaine GO:0048148 9.54 DRD2 DRD3 DRD4
24 acid secretion GO:0046717 9.52 DRD2 DRD3
25 dopamine receptor signaling pathway GO:0007212 9.5 DRD2 DRD3 DRD4
26 regulation of locomotion involved in locomotory behavior GO:0090325 9.43 DRD2 DRD3
27 negative regulation of protein secretion GO:0050709 9.43 DRD2 DRD3 DRD4
28 dopamine metabolic process GO:0042417 9.33 DRD2 DRD3 DRD4
29 adenylate cyclase-inhibiting dopamine receptor signaling pathway GO:0007195 9.13 DRD2 DRD3 DRD4
30 response to histamine GO:0034776 8.8 DRD2 DRD3 DRD4

Molecular functions related to Alcohol Abuse according to GeneCards Suite gene sharing:

id Name GO ID Score Top Affiliating Genes
1 drug binding GO:0008144 9.56 CNR1 DRD2 DRD3 DRD4
2 dopamine binding GO:0035240 9.33 DRD2 DRD3 DRD4
3 aldehyde dehydrogenase (NAD) activity GO:0004029 9.32 ALDH2 ALDH9A1
4 dopamine neurotransmitter receptor activity, coupled via Gi/Go GO:0001591 9.13 DRD2 DRD3 DRD4
5 dopamine neurotransmitter receptor activity GO:0004952 8.8 DRD2 DRD3 DRD4

Sources for Alcohol Abuse

3 CDC
7 CNVD
9 Cosmic
10 dbSNP
11 DGIdb
16 ExPASy
18 FMA
28 GO
29 GTR
30 HGMD
31 HMDB
32 HPO
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