MCID: ALC007
MIFTS: 60

Alcohol Dependence malady

Genetic diseases (common) category

Aliases & Classifications for Alcohol Dependence

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Sources:
45OMIM, 9Disease Ontology, 10diseasecard, 11DISEASES, 43Novoseek, 22GTR, 60UMLS
See all sources

Alcohol Dependence, Aliases & Descriptions:

Name: Alcohol Dependence 45 9 11 22
Alcohol Dependence, Protection Against 45 10
 
Alcoholic Intoxication, Chronic 60
Alcoholism 43


Classifications:

Malacards categories (disease lists): (See all malacards categories)
Global: Genetic diseases (common)


External Ids:

OMIM45 103780
Disease Ontology9 DOID:0050741

Summaries for Alcohol Dependence

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Wikipedia:63 Alcohol dependence is a substance-related disorder in which an individual is physically or... more...

MalaCards based summary: Alcohol Dependence, also known as alcohol dependence, protection against, is related to fetal alcohol syndrome and pancreatitis, and has symptoms including abnormality of the nervous system An important gene associated with Alcohol Dependence is ADH1C (alcohol dehydrogenase 1C (class I), gamma polypeptide), and among its related pathways are ethanol degradation II and Selective Serotonin Reuptake Inhibitor Pathway, Pharmacodynamics. The drugs chlordiazepoxide and citalopram and the compounds (tfmpp) and cgs-12066 have been mentioned in the context of this disorder. Affiliated tissues include brain, liver and testes.

Description from OMIM:45 103780

Related Diseases for Alcohol Dependence

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Diseases related to Alcohol Dependence via text searches within MalaCards or GeneCards Suite gene sharing:

(show top 50)    (show all 701)
idRelated DiseaseScoreTop Affiliating Genes
1fetal alcohol syndrome32.5ADH1B
2pancreatitis32.2ADH1C, ADH1B, ALDH2
3alcoholic pancreatitis32.1ADH1C, ADH1B, ALDH2
4conduct disorder31.5GABRA2
5alcohol abuse31.4ALDH2, ADH1C
6esophageal cancer31.3ADH4, ADH1B, ALDH2
7liver disease31.3ALDH2, ADH1B, ADH4
8antisocial personality disorder31.3ANKK1, HTR2A, HTR1B, GABRA6
9acute pancreatitis31.1ALDH2, ADH1B, ADH1C
10heroin dependence31.0ANKK1
11attention deficit-hyperactivity disorder31.0HTR1B, HTR2A
12obsessive-compulsive disorder30.7HTR1B, HTR2A
13substance abuse30.7ALDH2, ADH1B, ADH4
14bulimia nervosa30.7HTR2A, HTR1B
15alcoholic liver cirrhosis30.7ALDH2, ADH1B, ADH1C
16tongue squamous cell carcinoma30.3ALDH2, ADH1B
17liver cirrhosis30.3ADH1C, ADH1B, ALDH2
18fatty liver disease11.1
19fetal alcohol spectrum disorder10.9
20alcoholic cardiomyopathy10.8
21esophagitis10.7
22alcoholic neuropathy10.6
23blindness10.6
24hepatitis c10.6
25hepatocellular carcinoma10.6
26breast cancer10.6
27personality disorder10.5
28schizophrenia10.5
29colorectal cancer10.5
30hepatitis a10.5
31wernicke-korsakoff syndrome10.5
32anxiety disorder10.5
33nicotine dependence, protection against10.5ADH1B, HTR2A, ALDH2
34bipolar disorder10.4
35alexithymia10.4
36drug dependence10.4
37pancreatitis, hereditary10.4ALDH2, ADH1B, ADH1C
38nonalcoholic steatohepatitis10.4
39hepatitis c virus10.4
40alcohol-related neurodevelopmental disorder10.4
41atherosclerosis10.4
42cerebral atrophy10.4
43central pontine myelinolysis10.4
44hypertrophic cardiomyopathy10.4
45adenocarcinoma10.4
46alcoholic psychosis10.3
47pellagra10.3
48endotheliitis10.3
49hepatitis10.3
50post-traumatic stress disorder10.3

Graphical network of the top 20 diseases related to Alcohol Dependence:



Diseases related to alcohol dependence

Symptoms for Alcohol Dependence

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Symptoms by clinical synopsis from OMIM:

103780

Clinical features from OMIM:

103780

HPO human phenotypes related to Alcohol Dependence:

id Description Frequency HPO Source Accession
1 abnormality of the nervous system HP:0000707

Drugs & Therapeutics for Alcohol Dependence

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Genetic Tests for Alcohol Dependence

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Genetic tests related to Alcohol Dependence:

id Genetic test Affiliating Genes
1 Alcohol Dependence22

Anatomical Context for Alcohol Dependence

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MalaCards organs/tissues related to Alcohol Dependence:

31
Brain, Liver, Testes, Pituitary, Cortex, Amygdala, Prefrontal cortex, Heart, Thyroid, Cerebellum, Prostate, Neutrophil

Animal Models for Alcohol Dependence or affiliated genes

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Publications for Alcohol Dependence

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Articles related to Alcohol Dependence:

(show top 50)    (show all 953)
idTitleAuthorsYear
1
Genome-wide association study of alcohol dependence:significant findings in African- and European-Americans including novel risk loci. (24166409)
2014
2
Prevalence of and Potential Influencing Factors for Alcohol Dependence in Europe. (25342593)
2014
3
The role of constraint in the development of nicotine, marijuana, and alcohol dependence in young adulthood. (24343204)
2014
4
Pavlovian-to-Instrumental Transfer in Alcohol Dependence: A Pilot Study. (25359491)
2014
5
Safety and drinking outcomes among patients with comorbid alcohol dependence and borderline personality disorder treated with high-dose baclofen: a comparative cohort study. (25356633)
2014
6
Sodium oxybate: a review of its use in alcohol withdrawal syndrome and in the maintenance of abstinence in alcohol dependence. (24307430)
2014
7
Oppositional defiant disorder (ODD), the forerunner of alcohol dependence: a controlled study. (25453690)
2014
8
The efficacy of electroencephalogram neurofeedback training in cognition, anxiety, and depression in alcohol dependence syndrome: A case study. (25788809)
2014
9
Severity of alcohol dependence in the Swedish adult population: association with consumption and social factors. (23084032)
2013
10
Effects of family history of alcohol dependence on the subjective response to alcohol using the intravenous alcohol clamp. (23895557)
2013
11
Exploring the genetic architecture of alcohol dependence in African-Americans via analysis of a genomewide set of common variants. (24297757)
2013
12
Rare SERINC2 variants are specific for alcohol dependence in individuals of European descent. (23778322)
2013
13
A double-blind, placebo-controlled trial assessing the efficacy of varenicline tartrate for alcohol dependence. (23728065)
2013
14
Case-control association analysis of Dopamine receptor polymorphisms in alcohol dependence: a pilot study in Indian males. (24135011)
2013
15
Adjunctive aripiprazole therapy with escitalopram in patients with co-morbid major depressive disorder and alcohol dependence: clinical and neuroimaging evidence. (23325372)
2013
16
Authors' reply to Rolland et al.: "Management of alcohol dependence in patients with liver disease". (23999972)
2013
17
Evaluation of Relationships among Occupational Stress, Alcohol Dependence and Other Factors in Male Personnel in a Japanese Local Fire Fighting Organization. (24031141)
2012
18
Early-onset alcohol dependence increases the acoustic startle reflex. (22273252)
2012
19
Assessment and management of alcohol dependence and withdrawal in the acute hospital: concise guidance. (22783781)
2012
20
Cannabinoid receptor 1 gene is associated with alcohol dependence. (22085192)
2012
21
Serum NPY and BNDF response to a behavioral stressor in alcohol-dependent and healthy control participants. (21796371)
2011
22
Alcohol-induced persistent mild cognitive impairment with successful withdrawal from alcohol dependence--a case report. (21675042)
2011
23
Limited associations of dopamine system genes with alcohol dependence and related traits in the Irish Affected Sib Pair Study of Alcohol Dependence (IASPSAD). (21083670)
2011
24
Gabapentin combined with naltrexone for the treatment of alcohol dependence. (21454917)
2011
25
Lack of association between SNPs in the NEUROD2 gene and alcohol dependence in a German patient sample. (20880594)
2011
26
Extended telephone-based continuing care for alcohol dependence: 24-month outcomes and subgroup analyses. (21545667)
2011
27
A randomized, controlled study of treatment for alcohol dependence in patients awaiting liver transplantation. (21506242)
2011
28
Prodynorphin CpG-SNPs associated with alcohol dependence: elevated methylation in the brain of human alcoholics. (21521424)
2011
29
HIV, alcohol dependence, and the criminal justice system: a review and call for evidence-based treatment for released prisoners. (21171933)
2011
30
'For debate': NICE but needy: English guidance on managing alcohol dependence is not backed up by government alcohol policy. (21949191)
2011
31
Do premorbid predictors of alcohol dependence also predict the failure to recover from alcoholism? (20731973)
2010
32
A double-blind, placebo-controlled study of sertraline with naltrexone for alcohol dependence. (18644685)
2009
33
Predicting the effect of naltrexone and acamprosate in alcohol-dependent patients using genetic indicators. (19523047)
2009
34
MAOA-uVNTR polymorphism may modify the protective effect of ALDH2 gene against alcohol dependence in antisocial personality disorder. (19302089)
2009
35
Correlates of and relationship among lifetime alcohol abuse and alcohol dependence in older community residents in Brazil. (20191090)
2009
36
Alcohol dependence and polymorphisms of serotonin-related genes: association studies. (18405071)
2008
37
GABA-A2 receptor subunit gene (GABRA2) polymorphisms and risk for alcohol dependence. (17207817)
2008
38
Family-based association analyses of alcohol dependence phenotypes across DRD2 and neighboring gene ANKK1. (17850642)
2007
39
Diplotypes of the human serotonin 1B receptor promoter predict growth hormone responses to sumatriptan in abstinent alcohol-dependent men. (17217931)
2007
40
Association of alcohol dehydrogenase genes with alcohol dependence: a comprehensive analysis. (16571603)
2006
41
A joint genomewide linkage analysis of symptoms of alcohol dependence and conduct disorder. (17117961)
2006
42
Effect of ethanol on hypothalamic-pituitary-adrenal system response to psychosocial stress in sons of alcohol-dependent fathers. (15100697)
2004
43
Association of functional opioid receptor genotypes with alcohol dependence in Koreans. (15252283)
2004
44
Investigation of DUSP8 and CALCA in alcohol dependence. (13129832)
2003
45
Pharmacological mechanisms of naltrexone and acamprosate in the prevention of relapse in alcohol dependence. (14972776)
2003
46
Association between variants at the GABAAbeta2, GABAAalpha6 and GABAAgamma2 gene cluster and alcohol dependence in a Scottish population. (10578235)
1999
47
Human mu-opioid receptor variation and alcohol dependence. (9884158)
1998
48
Meta-analysis of the effects of alcohol dehydrogenase genotype on alcohol dependence and alcoholic liver disease. (9373704)
1997
49
Long-term observation of the hypothalamic-pituitary-thyroid (HPT) axis in alcohol-dependent patients. (8831864)
1996
50
Dopamine D1, D2 and D3 receptor genes in alcohol dependence. (8750359)
1995

Variations for Alcohol Dependence

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Clinvar genetic disease variations for Alcohol Dependence:

6
id Gene Variation Type Significance SNP ID Assembly Location
1ADH1CNM_000669.4(ADH1C): c.815G> A (p.Arg272Gln)single nucleotide variantprotectivers1693482GRCh37Chr 4, 100263965: 100263965
2ADH1CNM_000669.4(ADH1C): c.1048A> G (p.Ile350Val)single nucleotide variantprotectivers698GRCh37Chr 4, 100260789: 100260789
3ADH1BNM_000668.5(ADH1B): c.143A= (p.His48=)single nucleotide variantprotectivers1229984GRCh37Chr 4, 100239319: 100239319
4ADH1BNM_000668.5(ADH1B): c.1108C> T (p.Arg370Cys)single nucleotide variantprotectivers2066702GRCh37Chr 4, 100229017: 100229017
5ALDH2NM_000690.3(ALDH2): c.1510G> A (p.Glu504Lys)single nucleotide variantdrug response, protective, risk factorrs671GRCh37Chr 12, 112241766: 112241766

Expression for genes affiliated with Alcohol Dependence

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Search GEO for disease gene expression data for Alcohol Dependence.

Pathways for genes affiliated with Alcohol Dependence

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Pathways related to Alcohol Dependence according to GeneCards Suite gene sharing:

(show all 16)
idSuper pathways (with members indented)ScoreTop Affiliating Genes
1
Show member pathways
acetate conversion to acetyl-CoA36
oxidative ethanol degradation III36
ethanol degradation IV36
10.3ADH1B, ALDH2
210.3HTR1B, HTR2A
3
Show member pathways
10.3GABRA2, GABRA6
410.2ADH1B, ADH1A, ADH1C
510.2GABRA2, GABRA6, CHRNA6
6
Show member pathways
10.1GABRA2, GABRA6, ALDH2, CHRNA6
7
Show member pathways
10.1ADH1B, ADH1A, ADH4, ADH1C
8
Show member pathways
mitochondrial L-carnitine shuttle pathway36
Saturated fatty acid biosynthesis58
10.0ALDH2, ADH1B, ADH1A, ADH4, ADH1C
9
Show member pathways
10.0ALDH2, ADH1B, ADH1A, ADH4, ADH1C
10
Show member pathways
phenylalanine utilization36
noradrenaline and adrenaline degradation36
phenylalanine degradation IV36
10.0ADH1C, ADH4, ADH1A, ADH1B, ALDH2
11
Show member pathways
10.0ADH1C, ADH4, ADH1A, ADH1B, ALDH2
12
Show member pathways
10.0ADH1C, ADH4, ADH1A, ADH1B, ALDH2
13
Show member pathways
glycolysis36
gluconeogenesis36
Glycolysis and Gluconeogenesis36
10.0ADH1C, ADH4, ADH1A, ADH1B, ALDH2
14
Show member pathways
10.0CHRNA6, HTR2A, HTR1B, GABRA6, GABRA2
15
Show member pathways
9.9CHRNA6, HTR2A, HTR1B, GABRA6, GABRA2, TAS2R16

Compounds for genes affiliated with Alcohol Dependence

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Compounds related to Alcohol Dependence according to GeneCards Suite gene sharing:

(show top 50)    (show all 124)
idCompoundScoreTop Affiliating Genes
1(tfmpp)4310.7HTR1B, HTR2A
2cgs-120662810.7HTR2A, HTR1B
3sb 2242892810.7HTR2A, HTR1B
4pipamperone28 4311.7HTR2A, HTR1B
51-(2,5-dimethoxy-4-iodophenyl)-2-aminopropane4310.7HTR2A, HTR1B
6rsai4310.7ALDH2, ADH1C, ADH1B
7[3h]cgs82162810.6GABRA6, GABRA2
8[35s]tbps2810.6GABRA6, GABRA2
9[18f]fluoroethylflumazenil2810.6GABRA6, GABRA2
103,4-Dihydroxyphenylglycol2410.6ADH1A, ADH1C, ADH1B
119-cis-Retinal2410.6ADH1A, ADH1B, ADH1C
129-oh-risperidone2810.6HTR1B, HTR2A
13Retinal2410.6ADH1B, ADH1A, ADH1C
143,4-Dihydroxymandelaldehyde2410.6ADH1B, ADH1C, ADH1A
15gabazine2810.6GABRA2, GABRA6
16ro1545132810.6GABRA6, GABRA2
17venlafaxine43 49 24 1213.6GABRA6, HTR1B, HTR2A
185alpha-pregnan-3alpha-ol-20-one2810.6GABRA6, GABRA2
19Gamma-Aminobutyric acid2410.6GABRA2, GABRA6, ALDH2
20[3h]muscimol2810.6GABRA2, GABRA6
211-Hexanol2410.6ADH4, ADH1A, ADH1B
22[11c]flumazenil2810.6GABRA2, GABRA6
23Propyl alcohol2410.6ADH4, ADH1B, ADH1A
241-Pentanol2410.6ADH1A, ADH4, ADH1B
25risperidone43 49 28 59 24 1215.6ANKK1, HTR2A, HTR1B
26Isobutanol2410.6ADH1B, ADH4, ADH1A
27s330842810.6HTR1B, HTR2A
28Isopropyl alcohol2410.6ADH1B, ADH1A, ADH4
291-Butanol2410.6ADH1B, ADH1A, ADH4
30[3h]gabazine2810.6GABRA6, GABRA2
31betaine aldehyde43 2411.5ALDH2, ADH1B, ADH1C, ADH1A
323a,7a-Dihydroxy-5b-cholestan-26-al2410.5ADH1B, ADH1C, ADH1A, ALDH2
33cyanopindolol43 2811.5HTR1B, HTR2A
34acetaldehyde28 43 2412.5ADH1C, ADH1A, ADH1B, ALDH2
35sb 2166412810.5HTR2A, HTR1B
36bretazenil28 4311.5GABRA2, GABRA6
37NADP2410.5ADH1C, ADH1A, ALDH2, ADH1B
38tetrahydrodeoxycorticosterone28 4311.5GABRA6, GABRA2
39flumazenil28 43 1212.4GABRA6, GABRA2
40vitamin a43 24 1212.4ADH1C, ALDH2, ADH1B, ADH1A, ADH4
41nad28 2411.4ALDH2, ADH1B, ADH1A, ADH4, ADH1C
42nadh43 24 1212.4ADH4, ADH1A, ADH1C, ALDH2, ADH1B
43olanzapine43 49 28 24 1214.4HTR1B, HTR2A, ANKK1
44donitriptan2810.4HTR1B, HTR2A
45naratriptan43 28 1212.4HTR1B, HTR2A
46ethanol43 49 24 1213.3ADH1C, ALDH2, ADH4, ADH1A, ADH1B, ANKK1
47tfmpp2810.3HTR1B, HTR2A
482-methyl-5-ht43 2811.3HTR1B, HTR2A
49selective serotonin reuptake inhibitors4910.2GABRA6, HTR2A
50ly3448642810.0HTR2A, HTR1B

GO Terms for genes affiliated with Alcohol Dependence

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Cellular components related to Alcohol Dependence according to GeneCards Suite gene sharing:

idNameGO IDScoreTop Affiliating Genes
1postsynaptic membraneGO:004521110.2GABRA2, GABRA6, CHRNA6

Biological processes related to Alcohol Dependence according to GeneCards Suite gene sharing:

(show all 8)
idNameGO IDScoreTop Affiliating Genes
1alcohol metabolic processGO:000606610.3ADH4, ADH1A, ALDH2
2gamma-aminobutyric acid signaling pathwayGO:000721410.3GABRA2, GABRA6
3regulation of dopamine secretionGO:001405910.2CHRNA6, HTR2A, HTR1B
4negative regulation of synaptic transmission, glutamatergicGO:005196710.2HTR2A, HTR1B
5ethanol oxidationGO:000606910.2ALDH2, ADH1B, ADH1A, ADH4, ADH1C
6synaptic transmissionGO:000726810.1GABRA2, ALDH2, HTR2A, CHRNA6
7xenobiotic metabolic processGO:000680510.1ALDH2, ADH1B, ADH1A, ADH4, ADH1C
8regulation of behaviorGO:005079510.0HTR1B, HTR2A

Molecular functions related to Alcohol Dependence according to GeneCards Suite gene sharing:

(show all 7)
idNameGO IDScoreTop Affiliating Genes
1benzodiazepine receptor activityGO:000850310.4GABRA2, GABRA6
2alcohol dehydrogenase activity, zinc-dependentGO:000402410.3ADH1B, ADH1A, ADH4
3serotonin bindingGO:005137810.3HTR2A, HTR1B
4extracellular ligand-gated ion channel activityGO:000523010.3GABRA2, GABRA6
5alcohol dehydrogenase (NAD) activityGO:000402210.3ADH1A, ADH4, ADH1C
6serotonin receptor activityGO:000499310.2HTR1B, HTR2A
7GABA-A receptor activityGO:000489010.0GABRA2, GABRA6

Products for genes affiliated with Alcohol Dependence

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Sources for Alcohol Dependence

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3CDC
13ExPASy
14FMA
22GTR
23HGMD
24HMDB
25ICD10
26ICD10 via Orphanet
27ICD9CM
28IUPHAR
29KEGG
33MeSH
34MESH via Orphanet
35MGI
38NCIt
39NDF-RT
42NINDS
43Novoseek
45OMIM
46OMIM via Orphanet
50PubMed
51QIAGEN
56SNOMED-CT via Orphanet
60UMLS
61UMLS via Orphanet