MCID: ALC007
MIFTS: 58

Alcohol Dependence malady

Mental diseases category

Summaries for Alcohol Dependence

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66Wikipedia, 48OMIM, 34MalaCards
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Wikipedia:66 Alcohol dependence is a substance related disorder in which an individual is addicted to alcohol either... more...

MalaCards: Alcohol Dependence, also known as alcoholic intoxication, chronic, is related to alcohol abuse and conduct disorder. An important gene associated with Alcohol Dependence is GABRA2 (gamma-aminobutyric acid (GABA) A receptor, alpha 2), and among its related pathways are Selective Serotonin Reuptake Inhibitor Pathway, Pharmacodynamics and Ligand-gated ion channel transport. The drugs chlordiazepoxide and citalopram and the compounds (tfmpp) and cgs-12066 have been mentioned in the context of this disorder. Affiliated tissues include brain, liver and testes.

Description from OMIM:48 103780

Aliases & Classifications for Alcohol Dependence

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Sources:
9Disease Ontology, 23GTR, 48OMIM, 11DISEASES, 63UMLS
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Classifications:

Malacards categories (disease lists): (See all malacards categories)
Anatomical: Mental diseases


Aliases & Descriptions:

alcohol dependence 9 23 48 11
alcoholic intoxication, chronic 63


External Ids:

Disease Ontology9 DOID:0050741
OMIM48 103780

Related Diseases for Alcohol Dependence

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Sources:
18GeneCards, 19GeneDecks
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Diseases related to Alcohol Dependence via text searches within MalaCards or GeneCards/GeneDecks gene sharing:

(show top 50)    (show all 74)
idRelated DiseaseScoreTop Affiliating Genes
1alcohol abuse31.0ALDH2, ADH1C
2conduct disorder30.9GABRA2
3antisocial personality disorder30.7HTR1B, ANKK1, HTR2A, GABRA6
4nicotine dependence30.6TAS2R16, CHRNA6, ANKK1, NRXN3
5attention deficit hyperactivity disorder30.4HTR2A, HTR1B
6alcohol dependence, protection against30.3ADH1B, ADH1C
7obsessive-compulsive disorder30.3HTR2A, HTR1B
8alcoholic liver cirrhosis30.1ADH1C, ADH1B, ALDH2
9substance abuse30.1ALDH2, ADH1B, ADH4
10liver cirrhosis30.0ALDH2, ADH1B, ADH1C
11blindness10.6
12schizophrenia10.5
13personality disorder10.5
14liver disease10.4
15alexithymia10.4
16anxiety disorder10.4
17bipolar disorder10.4
18drug dependence10.4
19insomnia10.3
20post-traumatic stress disorder10.3
21cocaine abuse10.3
22hepatitis10.3
23neuronitis10.2
24cocaine dependence10.2
25pathological gambling10.2
26opiate dependence10.2
27substance dependence10.2
28fetal alcohol spectrum disorder10.1ADH1B
29heroin dependence10.1ANKK1
30cannabis dependence10.1
31major depressive disorder10.1
32dystonia10.1
33mood disorder10.1
34obesity10.1
35periodontitis10.1
36psychotic disorder10.1
37thyroiditis10.1
38myoclonus-dystonia10.1
39myoclonus10.1
40hangover10.1
41tongue squamous cell carcinoma10.1ALDH2, ADH1B
42alcoholic pancreatitis10.1ALDH2, ADH1B, ADH1C
43acute pancreatitis10.1ADH1B, ALDH2, ADH1C
44bulimia nervosa10.1HTR2A, HTR1B
45pancreatitis, chronic10.1ADH1C, ALDH2, ADH1B
46esophageal cancer10.1ADH1B, ALDH2, ADH4
47pancreatitis10.1ADH1C, ALDH2, ADH1B
48galactosemia10.1ADH1B, ALDH2, ADH4
49paranoid schizophrenia10.0
50pain disorder10.0

Graphical network of the top 20 diseases related to Alcohol Dependence:



Diseases related to alcohol dependence

Symptoms for Alcohol Dependence

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Sources:
48OMIM
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Symptoms by clinical synopsis from OMIM:

103780

Clinical features from OMIM:

103780

Drugs & Therapeutics for Alcohol Dependence

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Sources:
6CenterWatch, 43NIH Clinical Center, 7ClinicalTrials, 63UMLS, 42NDF-RT
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Approved drugs:

Search CenterWatch for Alcohol Dependence

Drug clinical trials:

Search ClinicalTrials for Alcohol Dependence

Search NIH Clinical Center for Alcohol Dependence

Search CenterWatch for Alcohol Dependence

Inferred drug relations via UMLS63/NDF-RT42:

Genetic Tests for Alcohol Dependence

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23GTR
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Genetic tests related to Alcohol Dependence:

id Genetic test Affiliating Genes
1 Alcohol Dependence23

Anatomical Context for Alcohol Dependence

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34MalaCards
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MalaCards organs/tissues related to Alcohol Dependence:

34
Brain, Liver, Testes, Pituitary, Amygdala, Cortex, Heart, Thyroid, Prefrontal cortex, Cerebellum, Prostate

Animal Models for Alcohol Dependence or affiliated genes

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Publications for Alcohol Dependence

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Sources:
53PubMed
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Articles related to Alcohol Dependence:

(show top 50)    (show all 907)
idTitleAuthorsYear
1
Genome-wide association study of alcohol dependence:significant findings in African- and European-Americans including novel risk loci. (24166409)
2014
2
The role of constraint in the development of nicotine, marijuana, and alcohol dependence in young adulthood. (24343204)
2014
3
Sodium oxybate: a review of its use in alcohol withdrawal syndrome and in the maintenance of abstinence in alcohol dependence. (24307430)
2014
4
Severity of alcohol dependence in the Swedish adult population: association with consumption and social factors. (23084032)
2013
5
Effects of family history of alcohol dependence on the subjective response to alcohol using the intravenous alcohol clamp. (23895557)
2013
6
Exploring the genetic architecture of alcohol dependence in African-Americans via analysis of a genomewide set of common variants. (24297757)
2013
7
Rare SERINC2 variants are specific for alcohol dependence in individuals of European descent. (23778322)
2013
8
A double-blind, placebo-controlled trial assessing the efficacy of varenicline tartrate for alcohol dependence. (23728065)
2013
9
Case-control association analysis of Dopamine receptor polymorphisms in alcohol dependence: a pilot study in Indian males. (24135011)
2013
10
Adjunctive aripiprazole therapy with escitalopram in patients with co-morbid major depressive disorder and alcohol dependence: clinical and neuroimaging evidence. (23325372)
2013
11
Authors' reply to Rolland et al.: "Management of alcohol dependence in patients with liver disease". (23999972)
2013
12
A randomised, double-blind, placebo-controlled, efficacy study of nalmefene, as-needed use, in patients with alcohol dependence. (23562264)
2013
13
Integrated care for comorbid alcohol dependence and anxiety and/or depressive disorder: study protocol for an assessor-blind, randomized controlled trial. (24245491)
2013
14
Baclofen and severe alcohol dependence: an uncertain harm-benefit balance as of early 2013. (24171218)
2013
15
Evaluation of Relationships among Occupational Stress, Alcohol Dependence and Other Factors in Male Personnel in a Japanese Local Fire Fighting Organization. (24031141)
2012
16
Early-onset alcohol dependence increases the acoustic startle reflex. (22273252)
2012
17
Assessment and management of alcohol dependence and withdrawal in the acute hospital: concise guidance. (22783781)
2012
18
Cannabinoid receptor 1 gene is associated with alcohol dependence. (22085192)
2012
19
The impact of contingency management on quality of life among cocaine abusers with and without alcohol dependence. (22211346)
2012
20
Serum NPY and BNDF response to a behavioral stressor in alcohol-dependent and healthy control participants. (21796371)
2011
21
Alcohol-induced persistent mild cognitive impairment with successful withdrawal from alcohol dependence--a case report. (21675042)
2011
22
Limited associations of dopamine system genes with alcohol dependence and related traits in the Irish Affected Sib Pair Study of Alcohol Dependence (IASPSAD). (21083670)
2011
23
Gabapentin combined with naltrexone for the treatment of alcohol dependence. (21454917)
2011
24
Lack of association between SNPs in the NEUROD2 gene and alcohol dependence in a German patient sample. (20880594)
2011
25
Extended telephone-based continuing care for alcohol dependence: 24-month outcomes and subgroup analyses. (21545667)
2011
26
A randomized, controlled study of treatment for alcohol dependence in patients awaiting liver transplantation. (21506242)
2011
27
Prodynorphin CpG-SNPs associated with alcohol dependence: elevated methylation in the brain of human alcoholics. (21521424)
2011
28
HIV, alcohol dependence, and the criminal justice system: a review and call for evidence-based treatment for released prisoners. (21171933)
2011
29
'For debate': NICE but needy: English guidance on managing alcohol dependence is not backed up by government alcohol policy. (21949191)
2011
30
Comorbid psychiatric diagnoses among individuals presenting to an addiction treatment program for alcohol dependence. (21303253)
2011
31
Do premorbid predictors of alcohol dependence also predict the failure to recover from alcoholism? (20731973)
2010
32
A double-blind, placebo-controlled study of sertraline with naltrexone for alcohol dependence. (18644685)
2009
33
Predicting the effect of naltrexone and acamprosate in alcohol-dependent patients using genetic indicators. (19523047)
2009
34
MAOA-uVNTR polymorphism may modify the protective effect of ALDH2 gene against alcohol dependence in antisocial personality disorder. (19302089)
2009
35
Correlates of and relationship among lifetime alcohol abuse and alcohol dependence in older community residents in Brazil. (20191090)
2009
36
Alcohol dependence and polymorphisms of serotonin-related genes: association studies. (18405071)
2008
37
GABA-A2 receptor subunit gene (GABRA2) polymorphisms and risk for alcohol dependence. (17207817)
2008
38
Family-based association analyses of alcohol dependence phenotypes across DRD2 and neighboring gene ANKK1. (17850642)
2007
39
Diplotypes of the human serotonin 1B receptor promoter predict growth hormone responses to sumatriptan in abstinent alcohol-dependent men. (17217931)
2007
40
Association of alcohol dehydrogenase genes with alcohol dependence: a comprehensive analysis. (16571603)
2006
41
A joint genomewide linkage analysis of symptoms of alcohol dependence and conduct disorder. (17117961)
2006
42
Effect of ethanol on hypothalamic-pituitary-adrenal system response to psychosocial stress in sons of alcohol-dependent fathers. (15100697)
2004
43
Association of functional opioid receptor genotypes with alcohol dependence in Koreans. (15252283)
2004
44
Investigation of DUSP8 and CALCA in alcohol dependence. (13129832)
2003
45
Pharmacological mechanisms of naltrexone and acamprosate in the prevention of relapse in alcohol dependence. (14972776)
2003
46
Association between variants at the GABAAbeta2, GABAAalpha6 and GABAAgamma2 gene cluster and alcohol dependence in a Scottish population. (10578235)
1999
47
Human mu-opioid receptor variation and alcohol dependence. (9884158)
1998
48
Meta-analysis of the effects of alcohol dehydrogenase genotype on alcohol dependence and alcoholic liver disease. (9373704)
1997
49
Long-term observation of the hypothalamic-pituitary-thyroid (HPT) axis in alcohol-dependent patients. (8831864)
1996
50
Dopamine D1, D2 and D3 receptor genes in alcohol dependence. (8750359)
1995

Variations for Alcohol Dependence

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Expression for genes affiliated with Alcohol Dependence

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Sources:
2BioGPS, 16Gene Expression Omnibus DataSets
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Expression patterns in normal tissues for genes affiliated with Alcohol Dependence

Search GEO for disease gene expression data for Alcohol Dependence.

Pathways for genes affiliated with Alcohol Dependence

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Sources:
51PathCards, 52PharmGKB, 56Reactome, 39NCBI BioSystems Database, 13EMD Millipore, 55R&D Systems, 31KEGG, 61Thomson Reuters
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Pathways related to Alcohol Dependence according to GeneCards/GeneDecks:

(show all 16)
idSuper pathways (with members indented)ScoreTop Affiliating Genes
110.2HTR1B, HTR2A
2
Show member pathways
10.2GABRA2, GABRA6
3
Show member pathways
acetate conversion to acetyl-CoA39
oxidative ethanol degradation III39
ethanol degradation IV39
10.2ADH1B, ALDH2
4
Show member pathways
10.1NRXN3, GABRA2, GABRA6
510.1CHRNA6, GABRA2, GABRA6
610.0ADH1A, ADH1B, ADH1C
7
Show member pathways
9.9GABRA2, GABRA6, ALDH2, CHRNA6
8
Show member pathways
9.9ADH1B, ADH1A, ADH4, ADH1C
9
Show member pathways
9.8CHRNA6, GABRA6, GABRA2, HTR2A, HTR1B
10
Show member pathways
phenylalanine utilization39
noradrenaline and adrenaline degradation39
phenylalanine degradation IV39
9.7ALDH2, ADH1B, ADH1A, ADH4, ADH1C
11
Show member pathways
9.7ALDH2, ADH1C, ADH4, ADH1A, ADH1B
12
Show member pathways
9.7ALDH2, ADH1B, ADH4, ADH1C, ADH1A
13
Show member pathways
mitochondrial L-carnitine shuttle pathway39
Saturated fatty acid biosynthesis61
9.7ADH1C, ADH4, ADH1A, ADH1B, ALDH2
14
Show member pathways
9.7ADH1B, ADH1A, ADH4, ADH1C, ALDH2
15
Show member pathways
glycolysis39
gluconeogenesis39
Glycolysis and Gluconeogenesis39
9.7ADH4, ALDH2, ADH1C, ADH1A, ADH1B
16
Show member pathways
9.7TAS2R16, CHRNA6, GABRA6, GABRA2, HTR1B, HTR2A

Compounds for genes affiliated with Alcohol Dependence

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Sources:
46Novoseek, 30IUPHAR, 52PharmGKB, 25HMDB, 12DrugBank, 62Tocris Bioscience
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Compounds related to Alcohol Dependence according to GeneCards/GeneDecks:

(show top 50)    (show all 124)
idCompoundScoreTop Affiliating Genes
1(tfmpp)4610.6HTR1B, HTR2A
2cgs-120663010.6HTR2A, HTR1B
3sb 2242893010.6HTR2A, HTR1B
4pipamperone30 4611.6HTR2A, HTR1B
51-(2,5-dimethoxy-4-iodophenyl)-2-aminopropane4610.6HTR2A, HTR1B
6gabazine3010.6GABRA2, GABRA6
7[3h]cgs82163010.6GABRA6, GABRA2
8[35s]tbps3010.6GABRA6, GABRA2
9[18f]fluoroethylflumazenil3010.5GABRA6, GABRA2
109-oh-risperidone3010.5HTR1B, HTR2A
11ro1545133010.5GABRA6, GABRA2
125alpha-pregnan-3alpha-ol-20-one3010.5GABRA6, GABRA2
13[3h]muscimol3010.5GABRA2, GABRA6
14[11c]flumazenil3010.5GABRA2, GABRA6
15s330843010.5HTR1B, HTR2A
16rsai4610.5ALDH2, ADH1C, ADH1B
17venlafaxine46 52 25 1213.5GABRA6, HTR1B, HTR2A
18[3h]gabazine3010.5GABRA6, GABRA2
19cyanopindolol46 3011.5HTR1B, HTR2A
20risperidone46 52 30 62 25 1215.5ANKK1, HTR2A, HTR1B
21sb 2166413010.5HTR2A, HTR1B
22Gamma-Aminobutyric acid2510.5GABRA6, ALDH2, GABRA2
233,4-Dihydroxyphenylglycol2510.5ADH1A, ADH1C, ADH1B
249-cis-Retinal2510.4ADH1A, ADH1B, ADH1C
25Retinal2510.4ADH1B, ADH1A, ADH1C
263,4-Dihydroxymandelaldehyde2510.4ADH1B, ADH1C, ADH1A
271-Hexanol2510.4ADH4, ADH1A, ADH1B
28bretazenil30 4611.4GABRA2, GABRA6
29Propyl alcohol2510.4ADH4, ADH1B, ADH1A
301-Pentanol2510.4ADH1A, ADH4, ADH1B
31Isobutanol2510.4ADH1B, ADH4, ADH1A
32Isopropyl alcohol2510.4ADH1B, ADH1A, ADH4
331-Butanol2510.4ADH4, ADH1A, ADH1B
34tetrahydrodeoxycorticosterone30 4611.4GABRA6, GABRA2
35flumazenil30 46 1212.4GABRA6, GABRA2
36naratriptan46 30 1212.3HTR1B, HTR2A
37betaine aldehyde46 2511.3ALDH2, ADH1B, ADH1C, ADH1A
383a,7a-Dihydroxy-5b-cholestan-26-al2510.3ADH1B, ADH1C, ADH1A, ALDH2
39olanzapine46 52 30 25 1214.3ANKK1, HTR1B, HTR2A
40acetaldehyde30 46 2512.3ADH1C, ADH1A, ADH1B, ALDH2
41tfmpp3010.3HTR1B, HTR2A
42NADP2510.2ADH1A, ADH1C, ALDH2, ADH1B
43donitriptan3010.2HTR1B, HTR2A
44ly3448643010.2HTR2A, HTR1B
45vitamin a46 25 1212.2ADH1C, ALDH2, ADH1B, ADH1A, ADH4
46nad30 2511.2ALDH2, ADH1B, ADH1A, ADH4, ADH1C
47nadh46 25 1212.1ADH4, ADH1A, ADH1C, ALDH2, ADH1B
48mcpp4610.1HTR1B, HTR2A
49ethanol46 52 25 1213.0ADH1C, ALDH2, ADH4, ADH1A, ADH1B, ANKK1
50selective serotonin reuptake inhibitors529.9GABRA6, HTR2A

GO Terms for genes affiliated with Alcohol Dependence

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Sources:
17Gene Ontology
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Cellular components related to Alcohol Dependence according to GeneCards/GeneDecks:

idNameGO IDScoreTop Affiliating Genes
1postsynaptic membraneGO:04521110.1GABRA2, GABRA6, CHRNA6

Biological processes related to Alcohol Dependence according to GeneCards/GeneDecks:

(show all 8)
idNameGO IDScoreTop Affiliating Genes
1gamma-aminobutyric acid signaling pathwayGO:00721410.2GABRA6, GABRA2
2alcohol metabolic processGO:00606610.1ALDH2, ADH4, ADH1A
3regulation of dopamine secretionGO:01405910.1HTR1B, HTR2A, CHRNA6
4negative regulation of synaptic transmission, glutamatergicGO:05196710.1HTR1B, HTR2A
5synaptic transmissionGO:0072689.9GABRA2, HTR2A, CHRNA6, ALDH2
6regulation of behaviorGO:0507959.9HTR1B, HTR2A
7ethanol oxidationGO:0060699.9ADH1A, ADH1C, ADH4, ALDH2, ADH1B
8xenobiotic metabolic processGO:0068059.8ADH1C, ADH4, ADH1A, ADH1B, ALDH2

Molecular functions related to Alcohol Dependence according to GeneCards/GeneDecks:

(show all 7)
idNameGO IDScoreTop Affiliating Genes
1benzodiazepine receptor activityGO:00850310.3GABRA6, GABRA2
2serotonin bindingGO:05137810.2HTR1B, HTR2A
3extracellular ligand-gated ion channel activityGO:00523010.2GABRA2, GABRA6
4alcohol dehydrogenase activity, zinc-dependentGO:00402410.1ADH1B, ADH1A, ADH4
5serotonin receptor activityGO:00499310.1HTR2A, HTR1B
6alcohol dehydrogenase (NAD) activityGO:00402210.1ADH1A, ADH4, ADH1C
7GABA-A receptor activityGO:0048909.9GABRA6, GABRA2

Products for genes affiliated with Alcohol Dependence

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Sources for Alcohol Dependence

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4CDC
14ExPASy
15FMA
23GTR
24HGMD
25HMDB
26ICD10
27ICD10 via Orphanet
28ICD9CM
30IUPHAR
31KEGG
36MeSH
37MESH via Orphanet
38MGI
41NCIt
42NDF-RT
45NINDS
46Novoseek
48OMIM
49OMIM via Orphanet
53PubMed
54QIAGEN
60SNOMED-CT via Orphanet
63UMLS
64UMLS via Orphanet