MCID: ALC007
MIFTS: 62

Alcohol Dependence

Categories: Genetic diseases, Mental diseases, Cancer diseases

Aliases & Classifications for Alcohol Dependence

MalaCards integrated aliases for Alcohol Dependence:

Name: Alcohol Dependence 54 12 29 14
Alcohol Dependence, Protection Against 54 13
Pharyngeal Neoplasms 42 69
Alcoholism 12 52
Alcoholic Intoxication, Chronic 69

Characteristics:

OMIM:

54
Inheritance:
probably multifactorial, genetically influenced


Classifications:



External Ids:

OMIM 54 103780
Disease Ontology 12 DOID:0050741
MeSH 42 D010610
NCIt 47 C3325
SNOMED-CT 64 126685009 95001001
SNOMED-CT via HPO 65 88425004
UMLS 69 C0031347

Summaries for Alcohol Dependence

MalaCards based summary : Alcohol Dependence, also known as alcohol dependence, protection against, is related to personality disorder and schizophrenia, and has symptoms including abnormality of the nervous system An important gene associated with Alcohol Dependence is ADH1B (Alcohol Dehydrogenase 1B (Class I), Beta Polypeptide), and among its related pathways/superpathways are Alcoholism and Peptide ligand-binding receptors. The drugs Acamprosate and Ethanol have been mentioned in the context of this disorder. Affiliated tissues include brain, liver and testes, and related phenotypes are behavior/neurological and homeostasis/metabolism

Wikipedia : 72 Alcohol dependence is a previous psychiatric diagnosis in which an individual is physically or... more...

Description from OMIM: 103780

Related Diseases for Alcohol Dependence

Diseases related to Alcohol Dependence via text searches within MalaCards or GeneCards Suite gene sharing:

(show top 50) (show all 127)
id Related Disease Score Top Affiliating Genes
1 personality disorder 31.2 ADH1B ALDH2 DRD2 HTR2A MAOA OPRM1
2 schizophrenia 31.1 DRD2 HTR1B HTR2A MAOA SLC6A3 SLC6A4
3 alcoholic liver cirrhosis 30.7 ALDH2 ALDH9A1 CYP2E1 DRD2 GABRA2 SLC6A4
4 intracranial cavernous angioma 11.1 DRD2 SLC6A3 SLC6A4
5 hyperthyroxinemia 11.1 DRD2 HTR2A SLC6A4
6 suppurative periapical periodontitis 11.1 DRD2 OPRK1 OPRM1 SLC6A4
7 pompholyx 11.1 DRD2 HTR2A SLC6A4
8 splenic abscess 11.1 DRD2 HTR2A SLC6A3 SLC6A4
9 ornithosis 11.1 DRD2 MAOA SLC6A4
10 alcohol abuse 11.1
11 eosinophilia-myalgia syndrome 11.1 DRD2 OPRM1 SLC6A3
12 uterus intravascular leiomyomatosis 11.1 MAOA OPRK1 SLC6A4
13 anodontia 11.0 HTR1B SLC6A3 SLC6A4
14 acute female pelvic peritonitis 11.0 DRD2 OPRK1 OPRM1 SLC6A3 SLC6A4
15 hallucinogen dependence 11.0 CHRNA6 DRD2 OPRK1 OPRM1 SLC6A4
16 contact dermatitis 11.0 DRD2 HTR2A SLC6A3
17 hemorrhagic cystitis 11.0 DRD2 MAOA SLC6A3 SLC6A4
18 bladder hepatoid adenocarcinoma 11.0 DRD2 SLC6A3 SLC6A4
19 neurogenic bladder 11.0 HTR2A MAOA SLC6A4
20 lethal hydranencephaly-diaphragmatic hernia syndrome 11.0 ADH1B ADH1C CYP2E1
21 pauci-immune glomerulonephritis with anca 11.0 DRD2 HTR2A MAOA SLC6A4
22 tinea pedis 11.0 MAOA SLC6A3 SLC6A4
23 angiokeratoma of mibelli 11.0 MAOA OPRK1 SLC6A4
24 postencephalitic parkinson disease 11.0 DRD2 HTR2A MAOA SLC6A4
25 chronic conjunctivitis 11.0 DRD2 HTR2A SLC6A3 SLC6A4
26 hereditary multiple exostoses 11.0 DRD2 HTR2A MAOA SLC6A4
27 tongue disease 11.0 ALDH2 DRD2 MAOA SLC6A3 SLC6A4
28 renpenning syndrome 11.0 HTR1B MAOA SLC6A4
29 carotid stenosis 11.0 ALDH2 DRD2 MAOA SLC6A3 SLC6A4
30 alcohol-related neurodevelopmental disorder 11.0 ADH1B ADH7 ALDH2
31 perinatal necrotizing enterocolitis 11.0 DRD2 SLC6A3 SLC6A4
32 pyromania 11.0 DRD2 HTR2A MAOA SLC6A3 SLC6A4
33 intrahepatic gall duct cancer 11.0 HTR2A MAOA SLC6A4
34 hepatitis d 11.0 DRD2 HTR2A MAOA SLC6A3 SLC6A4
35 bladder flat intraepithelial lesion 11.0 DRD2 HTR2A SLC6A4
36 chagas disease 11.0 HTR1B HTR2A MAOA SLC6A4
37 optic nerve glioma 10.9 ADH1B ALDH2 CYP2E1
38 acquired aneurysmal subarachnoid hemorrhage 10.9 HTR2A MAOA SLC6A4
39 keratosis 10.9 HTR2A MAOA SLC6A4
40 obsessive-compulsive personality disorder 10.9 HTR1B HTR2A MAOA NRXN3 SLC6A4
41 hypoglycemic coma 10.9 HTR2A MAOA SLC6A4
42 pervasive developmental disorder 10.9 OPRM1 SLC6A3 SLC6A4
43 partial motor epilepsy 10.9 DRD2 HTR1B HTR2A MAOA SLC6A4
44 albinism, oculocutaneous, type v 10.9 DRD2 HTR1B HTR2A MAOA SLC6A4
45 bone fracture 10.9 DRD2 HTR2A SLC6A3 SLC6A4
46 tropical calcific pancreatitis 10.9 ADH1B ADH1C ALDH2
47 bicipital tenosynovitis 10.9 ADH4 ALDH2
48 alpha 1-antitrypsin deficiency 10.9 ADH1B ADH1C ADH4 ALDH2 CYP2E1
49 colon mucinous adenocarcinoma 10.9 DRD2 GABRA2 HTR1B MAOA SLC6A3 SLC6A4
50 sexual disorder 10.9 DRD2 HTR2A MAOA NRXN3 SLC6A3 SLC6A4

Graphical network of the top 20 diseases related to Alcohol Dependence:



Diseases related to Alcohol Dependence

Symptoms & Phenotypes for Alcohol Dependence

Symptoms via clinical synopsis from OMIM:

54

Misc:
25 to 50% lifetime risk for sons and brothers of severely alcoholic men

Neuro:
alcoholism


Clinical features from OMIM:

103780

Human phenotypes related to Alcohol Dependence:

32
id Description HPO Frequency HPO Source Accession
1 abnormality of the nervous system 32 HP:0000707

MGI Mouse Phenotypes related to Alcohol Dependence:

44
id Description MGI Source Accession Score Top Affiliating Genes
1 behavior/neurological MP:0005386 10.1 ALDH2 CYP2E1 DRD2 GABRA2 HTR1B HTR2A
2 homeostasis/metabolism MP:0005376 9.93 ADH1C ADH7 ALDH2 CYP2E1 DRD2 GABRA2
3 endocrine/exocrine gland MP:0005379 9.91 ALDH2 DRD2 GATA4 HTR1B HTR2A OPRK1
4 integument MP:0010771 9.61 ALDH2 ALDH9A1 DRD2 GABRA2 GATA4 OPRK1
5 nervous system MP:0003631 9.36 SLC6A3 SLC6A4 ADH7 ALDH2 CHRNA6 DRD2

Drugs & Therapeutics for Alcohol Dependence

Drugs for Alcohol Dependence (from DrugBank, HMDB, Dgidb, PharmGKB, IUPHAR, NovoSeek, BitterDB):

(show top 50) (show all 451)
id Name Status Phase Clinical Trials Cas Number PubChem Id
1
Acamprosate Approved, Investigational Phase 4,Phase 3,Phase 2,Phase 1 77337-76-9 71158
2
Ethanol Approved Phase 4,Phase 3,Phase 2,Phase 1,Early Phase 1 64-17-5 702
3
Naltrexone Approved, Investigational, Vet_approved Phase 4,Phase 3,Phase 2,Phase 1,Early Phase 1 16590-41-3 5360515
4
Topiramate Approved Phase 4,Phase 3,Phase 2,Phase 1,Early Phase 1 97240-79-4 5284627
5
Lamotrigine Approved, Investigational Phase 4,Phase 3 84057-84-1 3878
6
Bupropion Approved Phase 4,Phase 3,Phase 2,Phase 1 34841-39-9, 34911-55-2 444
7
Dopamine Approved Phase 4,Phase 3,Phase 2,Phase 1,Early Phase 1 51-61-6, 62-31-7 681
8
Fluoxetine Approved, Vet_approved Phase 4,Phase 2 54910-89-3 3386
9
Disulfiram Approved Phase 4,Phase 2,Phase 3,Phase 1 97-77-8 3117
10
Prazosin Approved Phase 4,Phase 3,Phase 2,Phase 1,Early Phase 1 19216-56-9 4893
11
Histamine Approved, Investigational Phase 4,Phase 2 75614-87-8, 51-45-6 774
12
Varenicline Approved, Investigational Phase 4,Phase 2,Phase 3,Phase 1,Early Phase 1 249296-44-4 5310966
13
Methadone Approved Phase 4,Phase 3,Phase 2,Phase 1 76-99-3 4095
14
Buprenorphine Approved, Illicit, Investigational, Vet_approved Phase 4,Phase 3 52485-79-7 40400 644073
15
Naloxone Approved, Vet_approved Phase 4,Phase 3,Phase 1 465-65-6 5284596
16
Cocaine Approved, Illicit Phase 4,Phase 3,Phase 2,Phase 1 50-36-2 5760 446220
17
Amphetamine Approved, Illicit Phase 4,Phase 3,Phase 2 300-62-9 5826 3007
18
Gabapentin Approved, Investigational Phase 4,Phase 3,Phase 2 60142-96-3 3446
19
Valproic Acid Approved, Investigational Phase 4,Phase 3,Phase 2,Phase 1 99-66-1 3121
20
Ondansetron Approved Phase 4,Phase 3,Phase 2,Phase 1 99614-02-5 4595
21
Midazolam Approved, Illicit Phase 4 59467-70-8 4192
22
Propofol Approved, Investigational, Vet_approved Phase 4 2078-54-8 4943
23
Zonisamide Approved, Investigational Phase 4,Phase 3,Phase 2,Phase 1 68291-97-4 5734
24
Lorazepam Approved Phase 4,Phase 2,Phase 1 846-49-1 3958
25
Benzocaine Approved Phase 4,Phase 3,Phase 2,Phase 1 1994-09-7, 94-09-7 2337
26
Sertraline Approved Phase 4,Phase 2,Phase 1 79617-96-2 68617
27
Nicotine Approved Phase 4,Phase 2,Phase 3,Phase 1,Early Phase 1 54-11-5 942 89594
28
Methylphenidate Approved, Investigational Phase 4,Early Phase 1 113-45-1 4158
29
Aripiprazole Approved, Investigational Phase 4,Phase 2,Phase 3 129722-12-9 60795
30
Citalopram Approved Phase 4,Phase 2,Phase 1 59729-33-8 2771
31
Memantine Approved, Investigational Phase 4,Phase 3,Phase 2 19982-08-2 4054
32
Oxazepam Approved Phase 4 604-75-1 4616
33
Sodium oxybate Approved Phase 4 502-85-2 5360545
34 Piracetam Approved Phase 4,Phase 3,Phase 2 7491-74-9
35
Paroxetine Approved, Investigational Phase 4,Phase 3 61869-08-7 43815
36
Baclofen Approved Phase 4,Phase 2,Phase 3,Phase 1 1134-47-0 2284
37
Carbamazepine Approved, Investigational Phase 4 298-46-4 2554
38
Dutasteride Approved, Investigational Phase 4 164656-23-9 152945 6918296
39
Icodextrin Approved, Investigational Phase 4 337376-15-5
40
Ribavirin Approved Phase 4,Phase 2 36791-04-5 37542
41
Chlorzoxazone Approved Phase 4 95-25-0 2733
42
Guaifenesin Approved, Vet_approved Phase 4,Phase 2,Phase 1 93-14-1 3516
43
Risperidone Approved, Investigational Phase 4,Phase 2 106266-06-2 5073
44
Oxytocin Approved, Vet_approved Phase 4,Phase 3,Phase 2,Phase 1,Early Phase 1 50-56-6 439302 53477758
45
Acetylcysteine Approved, Investigational Phase 4,Phase 3,Phase 1,Phase 2,Early Phase 1 616-91-1 12035
46
Acetylcholine Approved Phase 4,Phase 2 51-84-3 187
47
Pregabalin Approved, Illicit, Investigational Phase 4,Phase 3,Phase 2 148553-50-8 5486971
48
Heroin Approved, Illicit Phase 4,Phase 2,Phase 1 561-27-3 5462328
49
Olanzapine Approved, Investigational Phase 4,Phase 3,Phase 2 132539-06-1 4585
50
Simvastatin Approved Phase 4 79902-63-9 54454

Interventional clinical trials:

(show top 50) (show all 1084)

id Name Status NCT ID Phase Drugs
1 Safety of Acamprosate for Alcohol Dependence in the Elderly: An Open-Label Study (SAFADIE) Unknown status NCT00655967 Phase 4 Acamprosate (Campral);Acamprosate
2 Trial for the Treatment of Alcohol Dependence Unknown status NCT00120601 Phase 4 Naltrexone;Acamprosate
3 Topiramate for Hospitalized Patients With Alcoholism: a 12-week Study Unknown status NCT01135602 Phase 4 Topiramate
4 Treatment of Alcohol Dependence and Comorbid Bipolar Disorder Unknown status NCT01015586 Phase 4 Lamotrigine;Placebo
5 Fluoxetine and Bupropion to Treat Patients With Depression and Alcoholism Unknown status NCT00449007 Phase 4 fluoxetine;bupropion
6 Antabuse in Severe Alcoholism: an Open Controlled Study Unknown status NCT00431262 Phase 4 antabuse (disulfiram)
7 Acamprosate vs. Placebo in Bipolar Alcoholics Unknown status NCT00466661 Phase 4 Acamprosate;Placebo
8 Citicoline for Alcohol Dependence Completed NCT02074735 Phase 4 Placebo;Citicoline
9 Extended-release Naltrexone for Alcohol Dependence in Primary Care Completed NCT00620750 Phase 4 Extended release injectable naltrexone (Vivitrol)
10 Study of Campral (Acamprosate) for Alcohol Dependence in a Family Medicine Clinic Completed NCT00381043 Phase 4 Acamprosate (Campral)
11 A Randomized Clinical Trial of Alcohol Care Management Completed NCT00419315 Phase 4
12 Zonisamide vs. Placebo in the Treatment of Alcohol Dependence Completed NCT00595556 Phase 4 zonisamide;Placebo
13 Trial of Seroquel SR for Alcohol Dependence and Comorbid Anxiety Completed NCT00352469 Phase 4 Seroquel XR
14 Disulfiram Combined With Lorazepam for Alcohol Dependence and Anxiety Disorder Completed NCT00721526 Phase 4 disulfiram plus lorazepam
15 Adjunctive Topiramate for Treatment of Alcohol Dependence in Patients With Bipolar Disorder Completed NCT00572117 Phase 4 Topiramate
16 Identifying Multiple Mechanisms of Change in Alcoholism Treatment Completed NCT01168960 Phase 4
17 Pharmacogenetic Response to Naltrexone For Alcohol Dependence Completed NCT00831272 Phase 4 naltrexone;Placebo
18 Prazosin Alcohol Dependence IVR Study Completed NCT00167687 Phase 4 prazosin
19 Injectable Versus Oral Naltrexone Treatment of Alcohol Dependence In Serious Mental Illness (SMI) Completed NCT00453804 Phase 4 injectable naltrexone;oral naltrexone
20 Comparative Trial Of Disulfiram, Naltrexone And Acamprosate In The Treatment Of Alcohol Dependence Completed NCT00435435 Phase 4 Disulfiram;Acamprosate;Naltexone
21 Sertraline Pharmacotherapy for Alcoholism Subtypes Completed NCT00368550 Phase 4 Sertraline;Placebo
22 Naltrexone for Bipolar Disorder and Alcohol Dependence Completed NCT00223275 Phase 4 Naltrexone
23 Tobacco Dependence in Alcoholism Treatment (Nicotine Patch/Naltrexone) Completed NCT00000437 Phase 4 Naltrexone Tablet and Nicotine Patch;Naltrexone Tablet and Placebo Patch;Placebo Tablet and Nicotine Patch;Placebo Tablet and Placebo Patch
24 Injectable Naltrexone Treatment of Alcohol Dependence in Serious Mental Illness (SMI) Completed NCT00453609 Phase 4 long-lasting injectable naltrexone
25 Quetiapine for Bipolar Disorder and Alcohol Dependence Completed NCT00457197 Phase 4 Placebo;Quetiapine
26 Genetic and Brain Mechanisms of Naltrexone's Treatment Efficacy for Alcoholism Completed NCT00920829 Phase 4 Drug;Placebo
27 Behavioral Therapy Plus Naltrexone for Alcoholism Completed NCT00000456 Phase 4 naltrexone (Revia)
28 Treatment for Alcoholism and Post-Traumatic Stress Disorder (Naltrexone) Completed NCT00006489 Phase 4 Naltrexone;Placebo
29 Treatment of Patients With Alcoholism and Attention Deficit Disorder Completed NCT00261872 Phase 4 Methylphenidate
30 Managing Alcoholism in People Who Do Not Respond to Naltrexone Completed NCT00115037 Phase 4 Naltrexone;placebo
31 Naltrexone Treatment of Alcohol Dependence Completed NCT00000452 Phase 4 naltrexone (Revia)
32 Naltrexone Treatment for Alcoholism Completed NCT00000438 Phase 4 naltrexone (Revia)
33 Sertraline for Alcohol Dependence and Depression Completed NCT00004554 Phase 4 naltrexone (Revia);sertraline (Zoloft);Placebo
34 Individually Adapted Therapy of Alcoholism Completed NCT00317031 Phase 4 Acamprosate or Naltrexone
35 Naltrexone Maintenance Treatment of Alcoholism Completed NCT00000450 Phase 4 Naltrexone Tablet;Matched Placebo Tablet
36 Treatment of Patients Suffering of Alcohol Dependence and Impaired Liver Function With Selincro® As-needed Use Completed NCT02197598 Phase 4 nalmefene
37 Smoking Cessation in Alcoholism Treatment Completed NCT00000454 Phase 4 nicotine replacement patch
38 Study of Aripiprazole in Subjects With Alcoholism Completed NCT00082199 Phase 4 Aripiprazole;Placebo
39 Effectiveness of Naltrexone Versus Placebo to Reduce Craving for Alcohol With Evaluation of Genetic Variability. Completed NCT00366626 Phase 4 Naltrexone;Placebo
40 Acamprosate in Alcoholics With Comorbid Anxiety or Depression Completed NCT00330174 Phase 4 Acamprosate
41 Naltrexone for Relapse Prevention Completed NCT00000442 Phase 4 naltrexone (Revia)
42 ALK21-018: Effects of Medisorb® Naltrexone (VIVITROL®) on Alcohol Craving in Treatment-seeking, Alcohol-dependent Adults Completed NCT00511836 Phase 4 VIVITROL 380 mg;Placebo
43 Efficacy Study of Memantine Hydrochloride and Escitalopram for the Treatment of Co-Morbid Depression and Alcoholism. Completed NCT00368862 Phase 4 Ebixa (memantine hydrochloride);Cipralex (escitalopram)
44 The Effects of Topiramate on Alcohol Use in Alcohol Dependent Subjects Completed NCT00329407 Phase 4 Topiramate (Topamax)
45 Comparative Study of Gamma-hydroxy Butyrate Versus Oxazepam in the Treatment of Alcohol Withdrawal Syndrome Completed NCT02090504 Phase 4 Sodium Oxybate (SMO);Oxazepam
46 The Effects of Levetiracetam on Alcohol Dependent Subjects Completed NCT00325182 Phase 4 Levetiracetam
47 Paroxetine for Comorbid Social Anxiety Disorder and Alcoholism Completed NCT00246441 Phase 4 Paroxetine;Placebo
48 Integrative Therapy in Alcoholism Completed NCT00159107 Phase 4 Acamprosate;Placebo
49 Use of Naltrexone in a Clinical Setting Completed NCT00000445 Phase 4 naltrexone (Revia)
50 Acamprosate Added to Escitalopram and Behavioral Treatment for Comorbid Depression and Alcoholism Completed NCT00452543 Phase 4 acamprosate;escitalopram;Placebo

Search NIH Clinical Center for Alcohol Dependence

Inferred drug relations via UMLS 69 / NDF-RT 48 :


Cochrane evidence based reviews: pharyngeal neoplasms

Genetic Tests for Alcohol Dependence

Genetic tests related to Alcohol Dependence:

id Genetic test Affiliating Genes
1 Alcohol Dependence 29

Anatomical Context for Alcohol Dependence

MalaCards organs/tissues related to Alcohol Dependence:

39
Brain, Liver, Testes, Pituitary, Cortex, Lung, Amygdala

Publications for Alcohol Dependence

Articles related to Alcohol Dependence:

(show top 50) (show all 1154)
id Title Authors Year
1
Effect of single-nucleotide polymorphisms in ADH1B, ADH4, ADH1C, OPRM1, DRD2, BDNF, and ALDH2 genes on alcohol dependence in a Caucasian population. ( 28805974 )
2017
2
Place and recovery from alcohol dependence: A journey through photovoice. ( 28886441 )
2017
3
Suicidal thoughts in persons treated for alcohol dependence: The role of selected demographic and clinical factors. ( 28893411 )
2017
4
From the neurobiological basis of comorbid alcohol dependence and depression to psychological treatment strategies: study protocol of a randomized controlled trial. ( 28454522 )
2017
5
Data on gut metagenomes of the patients with alcoholic dependence syndrome and alcoholic liver cirrhosis. ( 28138508 )
2017
6
The SLC6A3 gene possibly affects susceptibility to late-onset alcohol dependence but not specific personality traits in a Han Chinese population. ( 28182634 )
2017
7
Preserved affective sharing but impaired decoding of contextual complex emotions in alcohol dependence. ( 28092119 )
2017
8
Drinking-reduction goals offer potential to widen the options for measuring and treating alcohol dependence. ( 28456502 )
2017
9
Crossmodal processing of emotions in alcohol-dependence and Korsakoff syndrome. ( 28885888 )
2017
10
Traumatic Experiences, Revictimization and Posttraumatic Stress Disorder in German Inpatients Treated for Alcohol Dependence. ( 28952825 )
2017
11
Health-related quality of life in alcohol dependence: Similar cross-cultural impact beyond specific drinking habits. ( 28805530 )
2017
12
Differentiating the Effects of Familial Risk for Alcohol Dependence and Prenatal Exposure to Alcohol on Offspring Brain Morphology. ( 28084631 )
2017
13
ALCOHOL DEPENDENCE IN GASTROENTEROLOG YOUTPATIENT ON A PUBLIC HOSPITAL. ( 28954040 )
2017
14
Mobile phone messaging for illicit drug and alcohol dependence: A systematic review of the literature. ( 28474374 )
2017
15
Decreased hippocampal translocator protein (18a88kDa) expression in alcohol dependence: a [(11)C]PBR28 PET study. ( 28072413 )
2017
16
Psychopathological symptoms, defense mechanisms and time perspectives among subjects with alcohol dependence (AD) presenting different patterns of coping with stress. ( 28791198 )
2017
17
Prevalence of pathological gambling in patients with alcohol dependence syndrome attending a tertiary care center in South India. ( 28483101 )
2017
18
Baclofen Abuse due to Its Hypomanic Effect in Patients with Alcohol Dependence and Comorbid Major Depressive Disorder. ( 28449569 )
2017
19
Single Motherhood, Alcohol Dependence, and Smoking During Pregnancy: A Propensity Score Analysis. ( 28930062 )
2017
20
Effect of Disturbances of Zinc and Copper on the Physical and Mental Health Status of Patients with Alcohol Dependence. ( 28801722 )
2017
21
An endophenotype approach to the genetics of alcohol dependence: a genome wide association study of fast beta EEG in families of African ancestry. ( 28070124 )
2017
22
Reduced Drinking in Alcohol Dependence Treatment, What Is the Evidence? ( 28934736 )
2017
23
Heterogeneity of emotional and interpersonal difficulties in alcohol-dependence: A cluster analytic approach. ( 28411505 )
2017
24
Acute D3 Antagonist GSK598809 Selectively Enhances Neural Response During Monetary Reward Anticipation in Drug and Alcohol Dependence. ( 28042871 )
2017
25
Motivation to change and factors influencing motivation in alcohol dependence syndrome in a tertiary care hospital. ( 28827865 )
2017
26
Man stops stuttering with alcohol dependence drug. ( 28500247 )
2017
27
Promoter Polymorphism rs886205 Genotype Interacts With DNA Methylation of the ALDH2 Regulatory Region in Alcohol Dependence. ( 28430929 )
2017
28
Autoscopic Hallucination in Alcohol Dependence Syndrome: A Rare or Missed Phenomenon? ( 28811950 )
2017
29
Personality Profile and Short-term Treatment Outcome in Patients with Alcohol Dependence: A Study from South India. ( 28515554 )
2017
30
Complications after surgical treatment of femoral neck fractures in men with alcohol dependence syndrome: retrospective register analysis of 154 cases. ( 28493039 )
2017
31
Corrigendum to "Individualized relapse prediction: Personality measures and striatal and insular activity during reward-processing robustly predict relapse" [Drug and Alcohol Dependence 152 (2015) 93-101]. ( 28431752 )
2017
32
Predictors of coping and perceived expressed emotions in persons with alcohol dependence in India: a pilot study. ( 28784393 )
2017
33
Sleep waves and recovery from drug and alcohol dependence: Towards a rhythm analysis of sleep in residential treatment. ( 28525781 )
2017
34
Serum NUCB2/nesfatin-1 levels in different stages of alcohol dependence: Is there a relationship with craving? ( 28529367 )
2017
35
Higher Impulsivity and HIV-Risk Taking Behaviour in Males with Alcohol Dependence Compared to Bipolar Mania: A Pilot Study. ( 28456858 )
2017
36
Sexual dysfunction in women with alcohol dependence syndrome: A study from India. ( 28784408 )
2017
37
Abnormal intrinsic functional hubs in alcohol dependence: evidence from a voxelwise degree centrality analysis. ( 28814870 )
2017
38
Clinical Validation of Reduced Alcohol Consumption After Treatment for Alcohol Dependence Using the World Health Organization Risk Drinking Levels. ( 28019652 )
2017
39
Polygenic Scores for Major Depressive Disorder and Risk of Alcohol Dependence. ( 28813562 )
2017
40
The dose-effect relationship of baclofen in alcohol dependence: A 1-year cohort study. ( 28517239 )
2017
41
Erratum: Meta-Analysis Reveals Significant Association of the 3'-UTR VNTR in SLC6A3 With Alcohol Dependence. ( 28862750 )
2017
42
Gender Differences in Affects and Craving in Alcohol-Dependence: A Study During Alcohol Detoxification. ( 28060415 )
2017
43
Association of N-Methyl-D-Aspartate receptor 2B Subunit (GRIN2B) polymorphism with earlier age at onset of withdrawal symptoms in Indian alcohol dependent subjects. ( 26771436 )
2017
44
Acute D3 Antagonist GSK598809 Selectively Enhances Neural Response During Monetary Reward Anticipation in Drug and Alcohol Dependence. ( 28496172 )
2017
45
The Validity of the Montgomery-Asberg Depression Rating Scale in an Inpatient Sample with Alcohol Dependence. ( 28421616 )
2017
46
Change in non-abstinent WHO drinking risk levels and alcohol dependence: a 3 year follow-up study in the US general population. ( 28456501 )
2017
47
Cross-generational effects of alcohol dependence in humans on HRAS and TP53 methylation in offspring. ( 28799801 )
2017
48
Dorsolateral prefrontal cortex contributes to the impaired behavioral adaptation in alcohol dependence. ( 28491495 )
2017
49
Peripheral immune factors are elevated in women with current or recent alcohol dependence and associated with altered mood and memory. ( 28525828 )
2017
50
Genetic Contribution to Alcohol Dependence: Investigation of a Heterogeneous German Sample of Individuals with Alcohol Dependence, Chronic Alcoholic Pancreatitis, and Alcohol-Related Cirrhosis. ( 28714907 )
2017

Variations for Alcohol Dependence

ClinVar genetic disease variations for Alcohol Dependence:

6
id Gene Variation Type Significance SNP ID Assembly Location
1 TAS2R16 NM_016945.2(TAS2R16): c.516T> G (p.Asn172Lys) single nucleotide variant Pathogenic,risk factor rs846664 GRCh37 Chromosome 7, 122635173: 122635173
2 ADH1C NM_000669.4(ADH1C): c.815G> A (p.Arg272Gln) single nucleotide variant protective rs1693482 GRCh37 Chromosome 4, 100263965: 100263965
3 ADH1C NM_000669.4(ADH1C): c.1048A> G (p.Ile350Val) single nucleotide variant protective rs698 GRCh37 Chromosome 4, 100260789: 100260789
4 ADH1B NM_000668.5(ADH1B): c.143A= (p.His48=) single nucleotide variant protective rs1229984 GRCh37 Chromosome 4, 100239319: 100239319
5 ADH1B NM_000668.5(ADH1B): c.1108C> T (p.Arg370Cys) single nucleotide variant protective rs2066702 GRCh37 Chromosome 4, 100229017: 100229017
6 ALDH2 NM_000690.3(ALDH2): c.1510G> A (p.Glu504Lys) single nucleotide variant Pathogenic,protective,risk factor rs671 GRCh37 Chromosome 12, 112241766: 112241766

Copy number variations for Alcohol Dependence from CNVD:

7 (show top 50) (show all 130)
id CNVD ID Chromosom Start End Type Gene Symbol CNVD Disease
1 36180 1 72528018 72610078 Copy number Alcoholism
2 47606 10 95535368 95541692 Copy number LGI1 Alcoholism
3 55510 11 54453381 55222488 Copy number OR4A15 Alcoholism
4 55512 11 54453381 55222488 Copy number OR4A16 Alcoholism
5 55514 11 54453381 55222488 Copy number OR4C11 Alcoholism
6 55516 11 54453381 55222488 Copy number OR4C15 Alcoholism
7 55518 11 54453381 55222488 Copy number OR4C16 Alcoholism
8 55520 11 54453381 55222488 Copy number OR4C6 Alcoholism
9 55522 11 54453381 55222488 Copy number OR4P4 Alcoholism
10 55524 11 54453381 55222488 Copy number OR4S2 Alcoholism
11 55526 11 54453381 55222488 Copy number TRIM48 Alcoholism
12 63522 12 11916630 11919012 Copy number ETV6 Alcoholism
13 66840 12 33192673 33198641 Copy number FGD4 Alcoholism
14 66854 12 33259772 33296621 Copy number Alcoholism
15 78293 13 49964172 49982174 Copy number Alcoholism
16 122036 18 5195228 5200753 Copy number Alcoholism
17 136050 2 126142262 126191901 Copy number Alcoholism
18 137466 2 146561505 146640703 Copy number Alcoholism
19 145118 2 34552819 34590561 Copy number LTBP1 Alcoholism
20 150705 20 1335658 1343793 Copy number Alcoholism
21 150875 20 1506181 1547142 Copy number SIRPB1 Alcoholism
22 153918 20 41704335 41706581 Copy number IFT52 Alcoholism
23 164176 22 35465251 35493026 Copy number RABL4 Alcoholism
24 171099 3 163977466 164291801 Copy number Alcoholism
25 178116 3 68712334 68728352 Copy number Alcoholism
26 178149 3 68811511 68831828 Copy number Alcoholism
27 188748 4 68966876 69572080 Copy number TMPRSS11E Alcoholism
28 188750 4 68966876 69572080 Copy number TMPRSS11E2 Alcoholism
29 188752 4 68966876 69572080 Copy number UGT2B15 Alcoholism
30 188754 4 68966876 69572080 Copy number UGT2B17 Alcoholism
31 200626 5 57344829 57380923 Copy number Alcoholism
32 203890 6 103831330 103898013 Copy number Alcoholism
33 221060 7 142104463 142176424 Copy number PRSS1 Alcoholism
34 221062 7 142104463 142176424 Copy number TRY6 Alcoholism
35 238289 8 32756235 32814875 Copy number Alcoholism
36 245025 9 100343591 100357222 Copy number GABBR2 Alcoholism
37 248888 9 137616644 137620307 Copy number Alcoholism
38 251679 9 31281381 31282431 Copy number Alcoholism
39 258040 X 115046862 115061085 Copy number Alcoholism
40 258686 X 124296874 125546552 Copy number WDR40B Alcoholism
41 258687 X 124296874 125546552 Copy number WDR40C Alcoholism
42 258774 X 126390767 126443595 Copy number Alcoholism
43 258869 X 128284261 128345276 Copy number Alcoholism
44 258955 X 129071647 129072996 Copy number ELF4 Alcoholism
45 259008 X 130387579 130846282 Copy number LOC286467 Alcoholism
46 259009 X 130387579 130846282 Copy number OR13H1 Alcoholism
47 259338 X 134549966 134874484 Copy number CT45A1 Alcoholism
48 259339 X 134549966 134874484 Copy number CT45A2 Alcoholism
49 259340 X 134549966 134874484 Copy number CT45A3 Alcoholism
50 259341 X 134549966 134874484 Copy number CT45A4 Alcoholism

Expression for Alcohol Dependence

Search GEO for disease gene expression data for Alcohol Dependence.

Pathways for Alcohol Dependence

Pathways related to Alcohol Dependence according to KEGG:

37
id Name Kegg Source Accession
1 Alcoholism hsa05034

Pathways related to Alcohol Dependence according to GeneCards Suite gene sharing:

(show all 23)
id Super pathways Score Top Affiliating Genes
1
Show member pathways
13.46 CHRNA6 DRD2 GABRA2 HTR1B HTR2A OPRK1
2
Show member pathways
13.1 ADH1B ADH1C ADH4 ADH7 ALDH2 CYP2E1
3
Show member pathways
12.89 ALDH2 CHRNA6 GABRA2 MAOA NRXN3 SLC6A3
4
Show member pathways
12.51 ADH1B ADH1C ADH4 ADH7 ALDH2 ALDH9A1
5