MCID: ALC007
MIFTS: 59

Alcohol Dependence malady

Summaries for Alcohol Dependence

Sources:
64Wikipedia, 47OMIM, 33MalaCards
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Wikipedia:64 Alcohol dependence is a substance related disorder in which an individual is addicted to alcohol either... more...

MalaCards: Alcohol Dependence, also known as alcoholic intoxication, chronic, is related to alcohol abuse and nicotine dependence. An important gene associated with Alcohol Dependence is HTR2A (5-hydroxytryptamine (serotonin) receptor 2A, G protein-coupled), and among its related pathways are Class A/1 (Rhodopsin-like receptors) and Circadian entrainment. The drugs chlordiazepoxide and citalopram and the compounds ethanol and vitamin a have been mentioned in the context of this disorder. Affiliated tissues include liver, brain and cortex.

Description from OMIM:47 103780

Aliases & Classifications for Alcohol Dependence

Sources:
8Disease Ontology, 22GTR, 47OMIM, 10DISEASES, 61UMLS
See all sources

Aliases & Descriptions:

alcohol dependence 8 22 47 10
alcoholic intoxication, chronic 61


External Ids:

Disease Ontology8 DOID:0050741
OMIM47 103780

Related Diseases for Alcohol Dependence

Sources:
17GeneCards, 18GeneDecks
See all sources

Diseases related to Alcohol Dependence via text searches within MalaCards or GeneCards/GeneDecks gene sharing:

(show top 50)    (show all 79)
idRelated DiseaseScoreTop Affiliating Genes
1alcohol abuse31.0DRD2, SLC6A4, ALDH2, ADH1C
2nicotine dependence30.8DRD2, NRXN3, CHRNA6, ANKK1, TAS2R16, SLC6A4
3conduct disorder30.7DRD2, GABRA2, SLC6A4
4anxiety disorder30.7HTR2A, DRD2, SLC6A4
5bipolar disorder30.6SLC6A4, DRD2, HTR2A
6antisocial personality disorder30.6HTR1B, SLC6A4, ANKK1, GABRA6, DRD2, HTR2A
7alexithymia30.6ANKK1
8substance dependence30.5SLC6A4, DRD2
9cocaine dependence30.5DRD2, SLC6A4
10attention deficit hyperactivity disorder30.3HTR1B, HTR2A, DRD2, SLC6A4
11pathological gambling30.3DRD2
12obsessive-compulsive disorder30.1HTR1B, HTR2A, DRD2, SLC6A4
13substance abuse29.9DRD2, SLC6A4, ALDH2, ADH4, ADH1B
14schizoaffective disorder29.9HTR2A, DRD2, SLC6A4
15panic disorder29.9SLC6A4, HTR2A
16alcoholic liver cirrhosis29.9ADH1B, ADH1C, ALDH2
17social phobia29.9DRD2, SLC6A4
18generalized anxiety disorder29.9SLC6A4, HTR2A
19dependent personality disorder10.3
20bipolar i disorder10.3
21post-traumatic stress disorder10.3
22insomnia10.3
23cocaine abuse10.3
24cannabis dependence10.2
25n syndrome10.2
26wernicke-korsakoff syndrome10.2
27acute neonatal citrullinemia type i10.2
28major depressive disorder10.1
29myoclonus-dystonia10.1
30myoclonus10.1
31drug addiction10.1
32alcohol dependence, protection against10.1
33hangover10.1
34migraine10.0HTR1B, HTR2A, DRD2, SLC6A4
35parkinson's disease10.0HTR1B, HTR2A, DRD2, SLC6A4, ALDH2
36schizophrenia10.0HTR1B, HTR2A, DRD2, SLC6A4
37mood disorder10.0SLC6A4, DRD2, HTR2A, HTR1B
38obesity10.0ALDH2, DRD2, HTR2A
39personality disorder10.0HTR1B, DRD2, SLC6A4
40bulimia nervosa10.0SLC6A4, HTR2A, HTR1B
41liver cirrhosis10.0ADH1B, ADH1C, ALDH2
42alcoholic pancreatitis10.0ALDH2, ADH1C, ADH1B
43drug dependence10.0SLC6A4, DRD2
44heroin dependence10.0ANKK1, DRD2
45gilles de la tourette syndrome10.0HTR2A, DRD2, SLC6A4
46anorexia nervosa10.0SLC6A4, HTR2A
47psychotic disorder10.0SLC6A4, DRD2, HTR2A
48fetal alcohol spectrum disorder10.0ADH1B
49esophageal cancer10.0ALDH2, ADH4, ADH1B
50pancreatitis, chronic10.0ALDH2, ADH1C, ADH1B

Graphical network of the top 20 diseases related to Alcohol Dependence:



Diseases related to alcohol dependence

Clinical Features for Alcohol Dependence

Sources:
47OMIM
See all sources

Clinical features from OMIM:

103780

Clinical synopsis from OMIM:

103780

Drugs & Therapeutics for Alcohol Dependence

Sources:
5CenterWatch, 42NIH Clinical Center, 6ClinicalTrials, 61UMLS, 41NDF-RT
See all sources

Approved drugs:

Search CenterWatch for Alcohol Dependence

Drug clinical trials:

Search ClinicalTrials for Alcohol Dependence

Search NIH Clinical Center for Alcohol Dependence

Search CenterWatch for Alcohol Dependence

Inferred drug relations via UMLS61/NDF-RT41:

Genetic Tests for Alcohol Dependence

Sources:
22GTR
See all sources

Genetic tests related to Alcohol Dependence:

id Genetic test Affiliating Genes
1 Alcohol Dependence22

Anatomical Context for Alcohol Dependence

Sources:
33MalaCards
See all sources

MalaCards organs/tissues related to Alcohol Dependence:

33
Liver, Brain, Cortex, Cerebellum, Heart, Colon, T cells, B cells, Fetal brain, Prefrontal cortex, Amygdala, Fetal liver, Adrenal cortex, Pituitary

Animal Models for Alcohol Dependence or affiliated genes

Sources:
28inGenious Targeting Laboratory
See all sources

Publications for Alcohol Dependence

Sources:
51PubMed
See all sources

Articles related to Alcohol Dependence:

(show top 50)    (show all 1067)
idTitleAuthorsYear
1
Effects of family history of alcohol dependence on the subjective response to alcohol using the intravenous alcohol clamp. (23895557)
2013
2
Determination of genotype combinations that can predict the outcome of the treatment of alcohol dependence using the 5-HT(3) antagonist ondansetron. (23897038)
2013
3
Prevalence and correlates of alcohol dependence disorder among TB and HIV infected patients in Zambia. (24069309)
2013
4
Measurement invariance of DSM-IV alcohol, marijuana and cocaine dependence between community-sampled and clinically overselected studies. (23651171)
2013
5
Genome-wide DNA methylation analysis in alcohol dependence. (23387924)
2013
6
NKAIN1-SERINC2 is a functional, replicable and genome-wide significant risk gene region specific for alcohol dependence in subjects of European descent. (23455491)
2013
7
Cortical and subcortical volumes in adolescents with alcohol dependence but without substance or psychiatric comorbidities. (23916536)
2013
8
Reduced cannabinoid CB1 receptor binding in alcohol dependence measured with positron emission tomography. (22776901)
2013
9
Comorbidity of posttraumatic stress disorder with alcohol dependence among US adults: results from National Epidemiological Survey on Alcohol and Related Conditions. (23702490)
2013
10
Absence of P300 reduction in South African treatment-naA^ve adolescents with alcohol dependence. (22676302)
2013
11
Positively correlated miRNA-mRNA regulatory networks in mouse frontal cortex during early stages of alcohol dependence. (24148570)
2013
12
A twin study of alcohol dependence, binge eating, and compensatory behaviors. (23948525)
2013
13
TACR1 genotypes predict fMRI response to alcohol cues and level of alcohol dependence. (23078527)
2013
14
Abnormal white matter integrity and decision-making deficits in alcohol dependence. (24080516)
2013
15
Genetic variants in the fat mass- and obesity-associated (FTO) gene are associated with alcohol dependence. (23771786)
2013
16
The genetics of alcohol dependence: advancing towards systems-based approaches. (22854292)
2012
17
Childhood adversity, serotonin transporter (5-HTTLPR) genotype, and risk for cigarette smoking and nicotine dependence in alcohol dependent adults. (22172222)
2012
18
Childhood trauma, posttraumatic stress disorder, and alcohol dependence. (23584107)
2012
19
A randomized, controlled study of treatment for alcohol dependence in patients awaiting liver transplantation. (21506242)
2011
20
Past year treatment status and alcohol abuse symptoms among US adults with alcohol dependence. (21315517)
2011
21
MAOA interacts with the ALDH2 gene in anxiety-depression alcohol dependence. (20477771)
2010
22
Association of markers in the 3' region of the GluR5 kainate receptor subunit gene to alcohol dependence. (19320626)
2009
23
Dimensionality of lifetime alcohol abuse, dependence and binge drinking. (19095379)
2009
24
Childhood ADHD and conduct disorder as independent predictors of male alcohol dependence at age 40. (19261228)
2009
25
Comorbidity of alcohol and substance dependence with attention-deficit/hyperactivity disorder (ADHD). (18326548)
2008
26
Association studies of dopamine D4 receptor gene exon 3 in patients with alcohol dependence]. (19899572)
2008
27
Family-based association analyses of alcohol dependence phenotypes across DRD2 and neighboring gene ANKK1. (17850642)
2007
28
Heavy nicotine and alcohol use in alcohol dependence is associated with D2 dopamine receptor (DRD2) polymorphism. (16766132)
2007
29
Association of haplotypic variants in DRD2, ANKK1, TTC12 and NCAM1 to alcohol dependence in independent case control and family samples. (17761687)
2007
30
The role of the GABRA2 polymorphism in multiplex alcohol dependence families with minimal comorbidity: within-family association and linkage analyses. (17690794)
2007
31
Between- and within-family association test of the dopamine receptor D2 TaqIA polymorphism and alcohol abuse and dependence in a general population sample of adults. (17446975)
2007
32
Specificity of genetic and environmental risk factors for symptoms of cannabis, cocaine, alcohol, caffeine, and nicotine dependence. (17984400)
2007
33
Treatment rates for alcohol abuse and dependence remain low. (18217252)
2007
34
MAOA-uVNTR polymorphism in a Brazilian sample: further support for the association with impulsive behaviors and alcohol dependence. (16526025)
2006
35
Temperature dependence of benzyl alcohol- and 8-anilinonaphthalene-1-sulfonate-induced aggregation of recombinant human interleukin-1 receptor antagonist. (16548517)
2006
36
New alcohol abuse drugs emerging. Anti-craving meds are finally here to treat alcohol dependence, recognized as a disease of the brain. (16416546)
2005
37
The co-occurrence of DSM-IV alcohol abuse in DSM-IV alcohol dependence: results of the National Epidemiologic Survey on Alcohol and Related Conditions on heterogeneity that differ by population subgroup. (15351767)
2004
38
Pharmacological mechanisms of naltrexone and acamprosate in the prevention of relapse in alcohol dependence. (14972776)
2003
39
Association of a polymorphism of the serotonin 1B receptor gene and alcohol dependence with inactive aldehyde dehydrogenase-2. (11956970)
2002
40
Flupenthixol as a potential pharmacotreatment of alcohol and cocaine abuse/dependence. (10974602)
2000
41
Five exon 1 variants of mu opioid receptor and vulnerability to alcohol dependence. (10949117)
2000
42
The DRD2 gene and the risk for alcohol dependence in bipolar patients. (10881206)
2000
43
Coping and social skills training for alcohol and cocaine dependence. (10385943)
1999
44
The role of multifamily therapy in promoting retention in treatment of alcohol and cocaine dependence. (9522008)
1998
45
Effect of fetal alcohol exposure on adult symptoms of nicotine, alcohol, and drug dependence. (9660322)
1998
46
ADH genotypes and alcohol use and dependence in Europeans. (9802529)
1998
47
Use of social indicators in assessment of local community alcohol and other drug dependence treatment needs within Chicago. (8816117)
1996
48
Hypothesized neurochemical models for psychiatric syndromes in alcohol and drug dependence. (7504527)
1993
49
Alcohol and drug abuse-dependence disorders in psychopathic and nonpsychopathic criminal offenders. (2266219)
1990
50
Alcohol and opiate dependence; a review. (895146)
1977

Genetic Variations for Alcohol Dependence

Expression for genes affiliated with Alcohol Dependence

Sources:
1BioGPS, 15Gene Expression Omnibus DataSets
See all sources
Expression patterns in normal tissues for genes affiliated with Alcohol Dependence

Search GEO for disease gene expression data for Alcohol Dependence.

Pathways for genes affiliated with Alcohol Dependence

Sources:
54Reactome, 30KEGG, 38NCBI BioSystems Database, 50PharmGKB, 12EMD Millipore
See all sources

Pathways related to Alcohol Dependence according to GeneCards/GeneDecks:

(show all 19)
idSuper pathways (with members indented)ScoreTop Affiliating Genes
1
Hide members
11.2CHRNA6, HTR1B, HTR2A, DRD2, TAS2R16, GABRA2
2
Hide members
11.2HTR1B, DRD2, GABRA6, GABRA2, CHRNA6, SLC6A4
3
Hide members
11.2ADH6, ADH4, ADH1B, ADH1C, ADH1A, ALDH2
4
Hide members
11.2ADH1B, ALDH2, ADH1A, ADH7, ADH6, ADH4
5
Hide members
11.2ADH7, ADH1C, ALDH2, ADH4, ADH1B, ADH6
6
Hide members
11.2ALDH2, ADH1A, ADH4, ADH1C, ADH1B, ADH6
7
Hide members
11.2ADH6, ADH1B, ADH1C, ADH7, ADH1A, ADH4
811.2ADH4, ADH7, ADH6, ADH1B, ADH1C, ADH1A
9
Hide members
11.1ADH4, ADH1C, ADH1B, ADH6, ADH7, ADH1A
10
Hide members
11.1ADH1B, ADH1A, ADH4, ADH7, ADH6, ADH1C
11
Hide members
10.9HTR2A, DRD2, SLC6A4, HTR1B
12
Hide members
10.9CHRNA6, ALDH2, GABRA2, GABRA6
13
Hide members
10.9ADH4, ADH6, ADH1B, ALDH2
1410.8CHRNA6, GABRA2, GABRA6
1510.8ADH1C, ADH1A, ADH1B
16
Hide members
10.8ADH6, ADH1B, ALDH2
1710.7ALDH2, ADH1B
18
Tyrosine metabolism p.1 (dopamine)
Hide members
10.7ADH7, ADH1B
19
Hide members
10.7ADH1B, ADH1A

Compounds for genes affiliated with Alcohol Dependence

Sources:
45Novoseek, 50PharmGKB, 11DrugBank, 24HMDB, 29IUPHAR, 60Tocris Bioscience, 2BitterDB
See all sources

Compounds related to Alcohol Dependence according to GeneCards/GeneDecks:

(show top 50)    (show all 171)
idCompoundScoreTop Affiliating Genes
1ethanol45 50 11 2414.7ANKK1, ALDH2, ADH1C, ADH1B, ADH6, ADH4
2vitamin a45 11 2413.6ALDH2, ADH6, ADH7, ADH1B, ADH1C, ADH4
3nad29 2412.6ALDH2, ADH1A, ADH4, ADH1C, ADH1B, ADH7
4nadh45 11 2413.6ADH1A, ADH7, ADH6, ADH1B, ADH1C, ADH4
5betaine aldehyde45 2412.5ALDH2, ADH1A, ADH1C, ADH1B, ADH6, ADH7
6Nicotinamide-Adenine-Dinucleotide1111.5ADH7, ALDH2, ADH1A, ADH4, ADH1B, ADH1C
7acetaldehyde45 29 2413.5ADH1C, ADH7, ADH1A, ALDH2, ADH6, ADH1B
8choline45 11 2413.5ADH1A, ADH1C, ADH1B, ADH6, ADH7, SLC6A4
9nadph45 2412.4ADH1A, ALDH2, ADH1C, ADH1B, ADH6, ADH7
10dopamine45 29 11 2414.4ADH1B, ALDH2, SLC6A4, HTR2A, DRD2, HTR1B
11risperidone29 45 50 60 11 2416.4SLC6A4, ANKK1, DRD2, HTR2A, HTR1B
12clozapine45 29 50 1114.4DRD2, ANKK1, SLC6A4, HTR1B, HTR2A
13glycerol45 11 2413.4ADH6, ADH7, ADH1C, ADH1B, ADH1A
14maoa4511.3HTR2A, SLC6A4, DRD2, HTR1B
15ketanserin29 4512.3HTR2A, DRD2, SLC6A4, HTR1B
16venlafaxine50 45 11 2414.3SLC6A4, GABRA6, HTR2A, HTR1B
17fluoxetine50 45 29 1114.3HTR1B, DRD2, HTR2A, SLC6A4
18olanzapine50 45 29 11 2415.3HTR1B, HTR2A, DRD2, ANKK1
194-Iodopyrazole1111.2ADH1A, ADH1B, ADH1C
20Fomepizole1111.2ADH1B, ADH1C, ADH1A
21mcpp4511.2SLC6A4, HTR2A, HTR1B
22minaprine45 1112.2HTR2A, SLC6A4, DRD2
23roxindole29 4512.2HTR1B, DRD2, HTR2A
24pindolol45 29 1113.2HTR1B, HTR2A, SLC6A4
25amoxapine45 29 1113.2SLC6A4, DRD2, HTR2A
26terguride29 4512.2DRD2, HTR1B, HTR2A
27ritanserin29 4512.2HTR1B, HTR2A, DRD2
28trimipramine50 45 1113.1SLC6A4, DRD2, HTR2A
29sertindole29 45 1113.1HTR1B, HTR2A, DRD2
30ropinirole45 1112.1HTR2A, HTR1B, DRD2
31lisuride29 45 1113.1HTR1B, DRD2, HTR2A
32ergotamine29 45 1113.1HTR1B, HTR2A, DRD2
33fenfluramine29 45 1113.1HTR1B, SLC6A4, HTR2A
34pergolide29 45 1113.1HTR2A, HTR1B, DRD2
35pramipexole45 50 29 1114.1HTR1B, HTR2A, DRD2
36lorazepam45 50 1113.1DRD2, GABRA6, GABRA2
37asenapine29 1112.1DRD2, HTR2A, HTR1B
38cabergoline29 45 1113.1HTR1B, HTR2A, DRD2
39doxepin45 29 50 1114.0HTR2A, SLC6A4, DRD2
40rsai4510.9ADH1C, ADH1B, ALDH2
41Cyclohexylformamide1110.9ADH4, ADH1C
42(11c)-n-methylspiperone4510.9DRD2, HTR2A
43aripiprazole29 50 45 11 2414.9HTR2A, HTR1B, DRD2
44clotiapine4510.9HTR2A, DRD2
455,7-dihydroxytryptamine4510.9SLC6A4, HTR2A
46bupropion45 50 11 2413.8SLC6A4, DRD2, ANKK1
47ziprasidone50 29 45 1113.8HTR1B, HTR2A, DRD2
48yohimbine45 29 2 1113.8DRD2, HTR2A, HTR1B
49paroxetine45 50 29 1113.7SLC6A4, HTR2A, HTR1B
50Mesoridazine1110.4HTR2A, DRD2

GO Terms for genes affiliated with Alcohol Dependence

Sources:
16Gene Ontology
See all sources

Cellular components related to Alcohol Dependence according to GeneCards/GeneDecks:

idNameGO IDScoreTop Affiliating Genes
1integral to plasma membraneGO:00588711.1SLC6A4, NRXN3, GABRA6, DRD2, HTR2A, HTR1B

Biological processes related to Alcohol Dependence according to GeneCards/GeneDecks:

(show all 14)
idNameGO IDScoreTop Affiliating Genes
1ethanol oxidationGO:00606911.5ADH7, ALDH2, ADH1A, ADH4, ADH1C, ADH1B
2xenobiotic metabolic processGO:00680511.5ALDH2, ADH1A, ADH4, ADH1C, ADH1B, ADH6
3synaptic transmissionGO:00726811.4HTR1B, HTR2A, GABRA6, GABRA2, NRXN3, CHRNA6
4small molecule metabolic processGO:04428111.3ALDH2, ADH1A, ADH4, ADH1C, ADH1B, ADH6
5regulation of dopamine secretionGO:01405911.1HTR1B, HTR2A, DRD2, CHRNA6
6alcohol metabolic processGO:00606611.0ALDH2, ADH1A, ADH4
7negative regulation of synaptic transmission, glutamatergicGO:05196711.0DRD2, HTR2A, HTR1B
8response to ethanolGO:04547110.9HTR1B, ADH6, ADH7
9ethanol catabolic processGO:00606810.9ALDH2, ADH7
10regulation of behaviorGO:05079510.7HTR1B, HTR2A
11G-protein coupled receptor internalizationGO:00203110.7HTR1B, DRD2
12retinol metabolic processGO:04257210.7ADH7, ADH4
13temperature homeostasisGO:00165910.6DRD2, HTR2A
14vasoconstrictionGO:04231010.4SLC6A4, HTR1B

Molecular functions related to Alcohol Dependence according to GeneCards/GeneDecks:

(show all 8)
idNameGO IDScoreTop Affiliating Genes
1alcohol dehydrogenase (NAD) activityGO:00402211.2ADH7, ADH6, ADH1C, ADH4, ADH1A
2alcohol dehydrogenase activity, zinc-dependentGO:00402411.0ADH1A, ADH4, ADH1B, ADH7
3drug bindingGO:00814410.9HTR1B, HTR2A, DRD2
4benzodiazepine receptor activityGO:00850310.7GABRA2, GABRA6
5serotonin bindingGO:05137810.7HTR2A, HTR1B
6GABA-A receptor activityGO:00489010.7GABRA2, GABRA6
7retinol bindingGO:01984110.6ADH4, ADH7
8retinol dehydrogenase activityGO:00474510.4ADH7, ADH4

Products for genes affiliated with Alcohol Dependence

  • Antibodies
  • Proteins
  • Lysates
  • Antibodies

Sources for Alcohol Dependence

3CDC
13ExPASy
14FMA
22GTR
23HGMD
24HMDB
25ICD10
26ICD10 via Orphanet
27ICD9CM
29IUPHAR
30KEGG
35MeSH
36MESH via Orphanet
37MGI
40NCIt
41NDF-RT
44NINDS
45Novoseek
47OMIM
48OMIM via Orphanet
51PubMed
52QIAGEN
58SNOMED-CT via Orphanet
61UMLS
62UMLS via Orphanet