MCID: ALC007
MIFTS: 61

Alcohol Dependence malady

Summaries for Alcohol Dependence

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63Wikipedia, 46OMIM, 32MalaCards
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Wikipedia:63 Alcohol dependence is a substance related disorder in which an individual is addicted to alcohol either... more...

MalaCards: Alcohol Dependence, also known as alcoholic intoxication, chronic, is related to alcohol abuse and drug dependence. An important gene associated with Alcohol Dependence is HTR2A (5-hydroxytryptamine (serotonin) receptor 2A, G protein-coupled), and among its related pathways are Class A/1 (Rhodopsin-like receptors) and Circadian entrainment. The drugs chlordiazepoxide and citalopram and the compounds ethanol and vitamin a have been mentioned in the context of this disorder. Affiliated tissues include brain, liver and testes.

Description from OMIM:46 103780

Aliases & Classifications for Alcohol Dependence

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8Disease Ontology, 22GTR, 46OMIM, 10DISEASES, 60UMLS
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Aliases & Descriptions:

alcohol dependence 8 22 46 10
alcoholic intoxication, chronic 60


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Disease Ontology8 DOID:0050741
OMIM46 103780

Related Diseases for Alcohol Dependence

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17GeneCards, 18GeneDecks
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Diseases related to Alcohol Dependence via text searches within MalaCards or GeneCards/GeneDecks gene sharing:

(show top 50)    (show all 86)
idRelated DiseaseScoreTop Affiliating Genes
1alcohol abuse30.9DRD2, SLC6A4, ALDH2, ADH1C
2drug dependence30.9SLC6A4, DRD2
3nicotine dependence30.8DRD2, NRXN3, CHRNA6, ANKK1, TAS2R16, SLC6A4
4schizophrenia30.7HTR1B, HTR2A, DRD2, SLC6A4
5personality disorder30.7HTR1B, DRD2, SLC6A4
6conduct disorder30.7DRD2, GABRA2, SLC6A4
7anxiety disorder30.7HTR2A, DRD2, SLC6A4
8bipolar disorder30.6HTR2A, SLC6A4
9antisocial personality disorder30.6HTR1B, SLC6A4, ANKK1, GABRA6, DRD2, HTR2A
10cocaine dependence30.6DRD2, SLC6A4
11alexithymia30.6ANKK1
12substance dependence30.5SLC6A4, DRD2
13mood disorder30.3SLC6A4, DRD2, HTR2A, HTR1B
14attention deficit hyperactivity disorder30.2HTR1B, HTR2A, DRD2, SLC6A4
15pathological gambling30.2DRD2
16fetal alcohol spectrum disorder30.2ADH1B
17obsessive-compulsive disorder30.1HTR1B, HTR2A, DRD2, SLC6A4
18obesity30.1ALDH2, DRD2, HTR2A
19psychotic disorder30.1SLC6A4, DRD2, HTR2A
20substance abuse29.9DRD2, SLC6A4, ALDH2, ADH4, ADH1B
21schizoaffective disorder29.9HTR2A, DRD2, SLC6A4
22liver cirrhosis29.9ADH1B, ADH1C, ALDH2
23panic disorder29.9SLC6A4, HTR2A
24alcoholic liver cirrhosis29.9ADH1B, ADH1C, ALDH2
25social phobia29.9DRD2, SLC6A4
26generalized anxiety disorder29.9SLC6A4, HTR2A
27dependent personality disorder10.5
28liver disease10.4
29post-traumatic stress disorder10.3
30opiate dependence10.3
31major depressive disorder10.2
32cocaine abuse10.2
33alcoholic hepatitis10.2
34hepatitis10.2
35cannabis dependence10.2
36neuronitis10.2
37wernicke-korsakoff syndrome10.1
38acute neonatal citrullinemia type i10.1
39periodontitis10.1
40thyroiditis10.1
41myoclonus-dystonia10.1
42alcohol dependence, protection against10.1
43migraine10.0HTR1B, HTR2A, DRD2, SLC6A4
44parkinson's disease10.0HTR1B, HTR2A, DRD2, SLC6A4, ALDH2
45bulimia nervosa10.0SLC6A4, HTR2A, HTR1B
46alcoholic pancreatitis10.0ALDH2, ADH1C, ADH1B
47heroin dependence10.0ANKK1, DRD2
48gilles de la tourette syndrome10.0HTR2A, DRD2, SLC6A4
49anorexia nervosa10.0SLC6A4, HTR2A
50esophageal cancer10.0ALDH2, ADH4, ADH1B

Graphical network of the top 20 diseases related to Alcohol Dependence:



Diseases related to alcohol dependence

Clinical Features for Alcohol Dependence

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46OMIM
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Clinical features from OMIM:

103780

Clinical synopsis from OMIM:

103780

Drugs & Therapeutics for Alcohol Dependence

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Sources:
5CenterWatch, 41NIH Clinical Center, 6ClinicalTrials, 60UMLS, 40NDF-RT
See all sources

Approved drugs:

Search CenterWatch for Alcohol Dependence

Drug clinical trials:

Search ClinicalTrials for Alcohol Dependence

Search NIH Clinical Center for Alcohol Dependence

Search CenterWatch for Alcohol Dependence

Inferred drug relations via UMLS60/NDF-RT40:

Genetic Tests for Alcohol Dependence

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Sources:
22GTR
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Genetic tests related to Alcohol Dependence:

id Genetic test Affiliating Genes
1 Alcohol Dependence22

Anatomical Context for Alcohol Dependence

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32MalaCards
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MalaCards organs/tissues related to Alcohol Dependence:

32
Brain, Liver, Testes, Pituitary, Amygdala, Cortex, Heart, Prefrontal cortex, Thyroid, Colon, Prostate, Cerebellum, Endothelial

Animal Models for Alcohol Dependence or affiliated genes

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Publications for Alcohol Dependence

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50PubMed
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Articles related to Alcohol Dependence:

(show top 50)    (show all 1251)
idTitleAuthorsYear
1
Gabapentin: a new addition to the armamentarium for alcohol dependence? (24190363)
2014
2
Integrating GWASs and Human Protein Interaction Networks Identifies a Gene Subnetwork Underlying Alcohol Dependence. (24268660)
2013
3
Determination of genotype combinations that can predict the outcome of the treatment of alcohol dependence using the 5-HT(3) antagonist ondansetron. (23897038)
2013
4
Pharmacotherapy for alcohol dependence: status of current treatments. (23810221)
2013
5
Measurement invariance of DSM-IV alcohol, marijuana and cocaine dependence between community-sampled and clinically overselected studies. (23651171)
2013
6
NKAIN1-SERINC2 is a functional, replicable and genome-wide significant risk gene region specific for alcohol dependence in subjects of European descent. (23455491)
2013
7
Rescue of infralimbic mGluR2 deficit restores control over drug-seeking behavior in alcohol dependence. (23407939)
2013
8
"Drinking buddies" and alcohol dependence symptoms among African American men and women in Baltimore, MD. (22999417)
2013
9
Chronic cigarette smoking in alcohol dependence: associations with cortical thickness and N-acetylaspartate levels in the extended brain reward system. (22070867)
2013
10
Potential therapeutic role of glutamate transporter 1 for the treatment of alcohol dependence. (24409344)
2013
11
Cannabinoid receptor 1 gene is associated with alcohol dependence. (22085192)
2012
12
To approach or avoid alcohol? Automatic and self-reported motivational tendencies in alcohol dependence. (21895719)
2012
13
Alcohol dependence is related to overall internalizing psychopathology load rather than to particular internalizing disorders: evidence from a national sample. (21895708)
2012
14
The emergence of a recovery movement for alcohol and drug dependence. (22431840)
2012
15
Ethnic-specific meta-analyses of association between the OPRM1 A118G polymorphism and alcohol dependence among Asians and Caucasians. (22071118)
2012
16
Cholinergic receptor system as a target for treating alcohol abuse and dependence. (22574675)
2012
17
Reliability and validity of the PDS and PSS-I among participants with PTSD and alcohol dependence. (22480715)
2012
18
Serum NPY and BNDF response to a behavioral stressor in alcohol-dependent and healthy control participants. (21796371)
2011
19
Brain-derived neurotrophic factor, Val66Met single nucleotide polymorphism is not associated with alcohol dependence. (20978454)
2011
20
Brain morphology at entry into treatment for alcohol dependence is related to relapse propensity. (21601177)
2011
21
Efficacy of extended-release naltrexone in patients with relatively higher severity of alcohol dependence. (21575016)
2011
22
Smoking history, nicotine dependence, and changes in craving and mood during short-term smoking abstinence in alcohol dependent vs. control smokers. (21106299)
2011
23
Cocaine and amphetamine regulated transcript (CART) gene in the comorbidity of schizophrenia with alcohol use disorders and nicotine dependence. (20362026)
2010
24
Functional polymorphism of matrix metalloproteinase-9 (MMP-9) gene in alcohol dependence: family and case control study. (20197064)
2010
25
The serotonin transporter gene and risk for alcohol dependence: a meta-analytic review. (20060655)
2010
26
Serotonin 1B receptor imaging in alcohol dependence. (20172504)
2010
27
Alcohol-induced psychotic disorder: a comparative study on the clinical characteristics of patients with alcohol dependence and schizophrenia. (19895763)
2009
28
Association of markers in the 3' region of the GluR5 kainate receptor subunit gene to alcohol dependence. (19320626)
2009
29
Relation between plasma brain-derived neurotrophic factor and nerve growth factor in the male patients with alcohol dependence. (19560628)
2009
30
The serotonin 2A receptor gene in alcohol dependence and tobacco smoking. (19111403)
2009
31
Cannabinoid receptor 1 blocker rimonabant (SR 141716) for treatment of alcohol dependence: results from a placebo-controlled, double-blind trial. (18480689)
2008
32
A haplotype of the DRD1 gene is associated with alcohol dependence. (18341651)
2008
33
Association of NFKB1, which encodes a subunit of the transcription factor NF-kappaB, with alcohol dependence. (18079108)
2008
34
Patterns of alcohol consumption in bipolar patients comorbid for alcohol abuse or dependence. (16026491)
2005
35
A functional polymorphism in the promoter region of the tryptophan hydroxylase gene is associated with alcohol dependence in one aboriginal group in Taiwan. (15654285)
2005
36
Analysis of 5-hydroxytryptamine 2c receptor gene promoter variants as alcohol-dependence risk factors. (15304380)
2004
37
Alcohol abuse and dependence. A clinical update on alcoholism in the older population. (15461237)
2004
38
A functional polymorphism of the mu-opioid receptor gene is associated with naltrexone response in alcohol-dependent patients. (12813472)
2003
39
Age-dependent changes in electroencephalographic responses to alcohol consumption in subjects with aldehyde dehydrogenase-2 genetic variations. (12766630)
2003
40
Mutation analysis of the retinoid X receptor beta, nuclear-related receptor 1, and peroxisome proliferator-activated receptor alpha genes in schizophrenia and alcohol dependence: possible haplotype association of nuclear-related receptor 1 gene to alcohol dependence. (11840500)
2002
41
PAX-6 gene promoter polymorphism and other factors involved in brain atrophy in alcohol dependent patients]. (12043047)
2002
42
Association of a polymorphism of the 5HT2A receptor gene promoter region with alcohol dependence. (10089015)
1999
43
Temporal stability of diagnostic criteria for antisocial personality disorder in male alcohol dependent patients. (9891286)
1998
44
Structure of human chi chi alcohol dehydrogenase: a glutathione- dependent formaldehyde dehydrogenase. (9018047)
1997
45
Prevalence and correlates of drug use and DSM-IV drug dependence in the United States: results of the National Longitudinal Alcohol Epidemiologic Survey. (8880660)
1996
46
Alcohol dependence, family history, and D2 dopamine receptor function as neuroendocrinologically assessed with apomorphine. (8746924)
1995
47
Tiapride. A review of its pharmacology and therapeutic potential in the management of alcohol dependence syndrome. (7521826)
1994
48
Dramatic depletion of mesolimbic extracellular dopamine after withdrawal from morphine, alcohol or cocaine: a common neurochemical substrate for drug dependence. (1632615)
1992
49
What nicotine addiction and alcoholism teach us about other chemical dependencies. (2280295)
1990
50
Postgraduate certification in alcohol and drug dependence. (3904501)
1985

Genetic Variations for Alcohol Dependence

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Expression for genes affiliated with Alcohol Dependence

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Sources:
1BioGPS, 15Gene Expression Omnibus DataSets
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Expression patterns in normal tissues for genes affiliated with Alcohol Dependence

Search GEO for disease gene expression data for Alcohol Dependence.

Pathways for genes affiliated with Alcohol Dependence

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Sources:
53Reactome, 29KEGG, 37NCBI BioSystems Database, 49PharmGKB, 12EMD Millipore
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Pathways related to Alcohol Dependence according to GeneCards/GeneDecks:

(show all 19)
idSuper pathways (with members indented)ScoreTop Affiliating Genes
1
Hide members
11.2HTR1B, HTR2A, DRD2, GABRA6, GABRA2, CHRNA6
2
Hide members
11.2HTR1B, HTR2A, DRD2, GABRA6, GABRA2, CHRNA6
3
Hide members
11.2ADH7, ADH6, ADH1B, ADH1C, ADH4, ADH1A
411.2ALDH2, ADH1A, ADH4, ADH1C, ADH1B, ADH6
5
Hide members
11.2ALDH2, ADH1A, ADH4, ADH1C, ADH1B, ADH6
6
Hide members
11.2ALDH2, ADH1A, ADH4, ADH1C, ADH1B, ADH6
7
Hide members
11.2ALDH2, ADH1A, ADH4, ADH1C, ADH1B, ADH6
8
Hide members
11.2ADH1A, ALDH2, ADH4, ADH1C, ADH1B, ADH7
9
Hide members
11.1ADH1A, ADH4, ADH1C, ADH1B, ADH6, ADH7
10
Hide members
11.1ADH7, ADH6, ADH1B, ADH1C, ADH4, ADH1A
11
Hide members
10.9HTR1B, HTR2A, DRD2, SLC6A4
12
Hide members
10.9GABRA6, GABRA2, CHRNA6, ALDH2
13
Hide members
10.9ALDH2, ADH4, ADH1B, ADH6
1410.8GABRA6, GABRA2, CHRNA6
1510.8ADH1A, ADH1C, ADH1B
16
Hide members
10.8ALDH2, ADH1B, ADH6
1710.7ADH1B, ALDH2
18
Tyrosine metabolism p.1 (dopamine)
Hide members
10.7ADH7, ADH1B
19
Hide members
10.7ADH1B, ADH1A

Compounds for genes affiliated with Alcohol Dependence

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Sources:
44Novoseek, 49PharmGKB, 11DrugBank, 24HMDB, 28IUPHAR, 59Tocris Bioscience, 2BitterDB
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Compounds related to Alcohol Dependence according to GeneCards/GeneDecks:

(show top 50)    (show all 171)
idCompoundScoreTop Affiliating Genes
1ethanol44 49 11 2414.7ANKK1, ALDH2, ADH1C, ADH1B, ADH6, ADH4
2vitamin a44 11 2413.6ALDH2, ADH6, ADH7, ADH1B, ADH1C, ADH4
3nad28 2412.6ALDH2, ADH1A, ADH4, ADH1C, ADH1B, ADH7
4nadh44 11 2413.6ADH1A, ADH7, ADH6, ADH1B, ADH1C, ADH4
5betaine aldehyde44 2412.5ALDH2, ADH1A, ADH1C, ADH1B, ADH6, ADH7
6Nicotinamide-Adenine-Dinucleotide1111.5ADH7, ALDH2, ADH1A, ADH4, ADH1B, ADH1C
7acetaldehyde44 28 2413.5ADH1C, ADH7, ADH1A, ALDH2, ADH6, ADH1B
8choline44 11 2413.5ADH1A, ADH1C, ADH1B, ADH6, ADH7, SLC6A4
9nadph44 2412.4ADH1A, ALDH2, ADH1C, ADH1B, ADH6, ADH7
10dopamine44 28 11 2414.4ADH1B, ALDH2, SLC6A4, HTR2A, DRD2, HTR1B
11risperidone28 44 49 59 11 2416.4SLC6A4, ANKK1, DRD2, HTR2A, HTR1B
12clozapine44 28 49 1114.4DRD2, ANKK1, SLC6A4, HTR1B, HTR2A
13glycerol44 11 2413.4ADH6, ADH7, ADH1C, ADH1B, ADH1A
14maoa4411.3HTR2A, SLC6A4, DRD2, HTR1B
15ketanserin28 4412.3HTR2A, DRD2, SLC6A4, HTR1B
16venlafaxine49 44 11 2414.3SLC6A4, GABRA6, HTR2A, HTR1B
17fluoxetine49 44 28 1114.3HTR1B, DRD2, HTR2A, SLC6A4
18olanzapine49 44 28 11 2415.3HTR1B, HTR2A, DRD2, ANKK1
194-Iodopyrazole1111.2ADH1A, ADH1B, ADH1C
20Fomepizole1111.2ADH1B, ADH1C, ADH1A
21mcpp4411.2SLC6A4, HTR2A, HTR1B
22minaprine44 1112.2HTR2A, SLC6A4, DRD2
23roxindole28 4412.2HTR1B, DRD2, HTR2A
24pindolol44 28 1113.2HTR1B, HTR2A, SLC6A4
25amoxapine44 28 1113.2SLC6A4, DRD2, HTR2A
26terguride28 4412.2DRD2, HTR1B, HTR2A
27ritanserin28 4412.2HTR1B, HTR2A, DRD2
28trimipramine49 44 1113.1SLC6A4, DRD2, HTR2A
29sertindole28 44 1113.1HTR1B, HTR2A, DRD2
30ropinirole44 1112.1HTR2A, HTR1B, DRD2
31lisuride28 44 1113.1HTR1B, DRD2, HTR2A
32ergotamine28 44 1113.1HTR1B, HTR2A, DRD2
33fenfluramine28 44 1113.1HTR1B, SLC6A4, HTR2A
34pergolide28 44 1113.1HTR2A, HTR1B, DRD2
35pramipexole44 49 28 1114.1HTR1B, HTR2A, DRD2
36lorazepam44 49 1113.1DRD2, GABRA6, GABRA2
37asenapine28 1112.1DRD2, HTR2A, HTR1B
38cabergoline28 44 1113.1HTR1B, HTR2A, DRD2
39doxepin44 28 49 1114.0HTR2A, SLC6A4, DRD2
40rsai4410.9ADH1C, ADH1B, ALDH2
41Cyclohexylformamide1110.9ADH4, ADH1C
42(11c)-n-methylspiperone4410.9DRD2, HTR2A
43aripiprazole28 49 44 11 2414.9HTR2A, HTR1B, DRD2
44clotiapine4410.9HTR2A, DRD2
455,7-dihydroxytryptamine4410.9SLC6A4, HTR2A
46bupropion44 49 11 2413.8SLC6A4, DRD2, ANKK1
47ziprasidone49 28 44 1113.8HTR1B, HTR2A, DRD2
48yohimbine44 28 2 1113.8DRD2, HTR2A, HTR1B
49paroxetine44 49 28 1113.7SLC6A4, HTR2A, HTR1B
50Mesoridazine1110.4HTR2A, DRD2

GO Terms for genes affiliated with Alcohol Dependence

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16Gene Ontology
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Cellular components related to Alcohol Dependence according to GeneCards/GeneDecks:

idNameGO IDScoreTop Affiliating Genes
1integral to plasma membraneGO:00588711.1SLC6A4, NRXN3, GABRA6, DRD2, HTR2A, HTR1B

Biological processes related to Alcohol Dependence according to GeneCards/GeneDecks:

(show all 14)
idNameGO IDScoreTop Affiliating Genes
1ethanol oxidationGO:00606911.5ADH7, ALDH2, ADH1A, ADH4, ADH1C, ADH1B
2xenobiotic metabolic processGO:00680511.5ALDH2, ADH1A, ADH4, ADH1C, ADH1B, ADH6
3synaptic transmissionGO:00726811.4HTR1B, HTR2A, GABRA6, GABRA2, NRXN3, CHRNA6
4small molecule metabolic processGO:04428111.3ALDH2, ADH1A, ADH4, ADH1C, ADH1B, ADH6
5regulation of dopamine secretionGO:01405911.1HTR1B, HTR2A, DRD2, CHRNA6
6alcohol metabolic processGO:00606611.0ALDH2, ADH1A, ADH4
7negative regulation of synaptic transmission, glutamatergicGO:05196711.0DRD2, HTR2A, HTR1B
8response to ethanolGO:04547110.9HTR1B, ADH6, ADH7
9ethanol catabolic processGO:00606810.9ALDH2, ADH7
10regulation of behaviorGO:05079510.7HTR1B, HTR2A
11G-protein coupled receptor internalizationGO:00203110.7HTR1B, DRD2
12retinol metabolic processGO:04257210.7ADH7, ADH4
13temperature homeostasisGO:00165910.6DRD2, HTR2A
14vasoconstrictionGO:04231010.4SLC6A4, HTR1B

Molecular functions related to Alcohol Dependence according to GeneCards/GeneDecks:

(show all 8)
idNameGO IDScoreTop Affiliating Genes
1alcohol dehydrogenase (NAD) activityGO:00402211.2ADH7, ADH6, ADH1C, ADH4, ADH1A
2alcohol dehydrogenase activity, zinc-dependentGO:00402411.0ADH1A, ADH4, ADH1B, ADH7
3drug bindingGO:00814410.9HTR1B, HTR2A, DRD2
4benzodiazepine receptor activityGO:00850310.7GABRA2, GABRA6
5serotonin bindingGO:05137810.7HTR2A, HTR1B
6GABA-A receptor activityGO:00489010.7GABRA2, GABRA6
7retinol bindingGO:01984110.6ADH4, ADH7
8retinol dehydrogenase activityGO:00474510.4ADH7, ADH4

Products for genes affiliated with Alcohol Dependence

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  • Antibodies
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Sources for Alcohol Dependence

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3CDC
13ExPASy
14FMA
22GTR
23HGMD
24HMDB
25ICD10
26ICD10 via Orphanet
27ICD9CM
28IUPHAR
29KEGG
34MeSH
35MESH via Orphanet
36MGI
39NCIt
40NDF-RT
43NINDS
44Novoseek
46OMIM
47OMIM via Orphanet
50PubMed
51QIAGEN
57SNOMED-CT via Orphanet
60UMLS
61UMLS via Orphanet