MCID: ALC007
MIFTS: 61

Alcohol Dependence malady

Summaries for Alcohol Dependence

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63Wikipedia, 46OMIM, 32MalaCards
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Wikipedia:63 Alcohol dependence is a substance related disorder in which an individual is addicted to alcohol either... more...

MalaCards: Alcohol Dependence, also known as alcoholic intoxication, chronic, is related to alcohol abuse and drug dependence. An important gene associated with Alcohol Dependence is HTR2A (5-hydroxytryptamine (serotonin) receptor 2A, G protein-coupled), and among its related pathways are Class A/1 (Rhodopsin-like receptors) and Circadian entrainment. The drugs chlordiazepoxide and citalopram and the compounds ethanol and vitamin a have been mentioned in the context of this disorder. Affiliated tissues include brain, liver and testes.

Description from OMIM:46 103780

Aliases & Classifications for Alcohol Dependence

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8Disease Ontology, 22GTR, 46OMIM, 10DISEASES, 60UMLS
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Aliases & Descriptions:

alcohol dependence 8 22 46 10
alcoholic intoxication, chronic 60


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Disease Ontology8 DOID:0050741
OMIM46 103780

Related Diseases for Alcohol Dependence

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17GeneCards, 18GeneDecks
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Diseases related to Alcohol Dependence via text searches within MalaCards or GeneCards/GeneDecks gene sharing:

(show top 50)    (show all 86)
idRelated DiseaseScoreTop Affiliating Genes
1alcohol abuse30.9DRD2, SLC6A4, ALDH2, ADH1C
2drug dependence30.9SLC6A4, DRD2
3nicotine dependence30.8DRD2, NRXN3, CHRNA6, ANKK1, TAS2R16, SLC6A4
4schizophrenia30.7HTR1B, HTR2A, DRD2, SLC6A4
5personality disorder30.7HTR1B, DRD2, SLC6A4
6conduct disorder30.7DRD2, GABRA2, SLC6A4
7anxiety disorder30.7HTR2A, DRD2, SLC6A4
8bipolar disorder30.6HTR2A, SLC6A4
9antisocial personality disorder30.6HTR1B, SLC6A4, ANKK1, GABRA6, DRD2, HTR2A
10cocaine dependence30.6DRD2, SLC6A4
11alexithymia30.6ANKK1
12substance dependence30.5SLC6A4, DRD2
13mood disorder30.3SLC6A4, DRD2, HTR2A, HTR1B
14attention deficit hyperactivity disorder30.2HTR1B, HTR2A, DRD2, SLC6A4
15pathological gambling30.2DRD2
16fetal alcohol spectrum disorder30.2ADH1B
17obsessive-compulsive disorder30.1HTR1B, HTR2A, DRD2, SLC6A4
18obesity30.1ALDH2, DRD2, HTR2A
19psychotic disorder30.1SLC6A4, DRD2, HTR2A
20substance abuse29.9DRD2, SLC6A4, ALDH2, ADH4, ADH1B
21schizoaffective disorder29.9HTR2A, DRD2, SLC6A4
22liver cirrhosis29.9ADH1B, ADH1C, ALDH2
23panic disorder29.9SLC6A4, HTR2A
24alcoholic liver cirrhosis29.9ADH1B, ADH1C, ALDH2
25social phobia29.9DRD2, SLC6A4
26generalized anxiety disorder29.9SLC6A4, HTR2A
27dependent personality disorder10.5
28liver disease10.4
29post-traumatic stress disorder10.3
30opiate dependence10.3
31major depressive disorder10.2
32cocaine abuse10.2
33alcoholic hepatitis10.2
34hepatitis10.2
35cannabis dependence10.2
36neuronitis10.2
37wernicke-korsakoff syndrome10.1
38acute neonatal citrullinemia type i10.1
39periodontitis10.1
40thyroiditis10.1
41myoclonus-dystonia10.1
42alcohol dependence, protection against10.1
43migraine10.0HTR1B, HTR2A, DRD2, SLC6A4
44parkinson's disease10.0HTR1B, HTR2A, DRD2, SLC6A4, ALDH2
45bulimia nervosa10.0SLC6A4, HTR2A, HTR1B
46alcoholic pancreatitis10.0ALDH2, ADH1C, ADH1B
47heroin dependence10.0ANKK1, DRD2
48gilles de la tourette syndrome10.0HTR2A, DRD2, SLC6A4
49anorexia nervosa10.0SLC6A4, HTR2A
50esophageal cancer10.0ALDH2, ADH4, ADH1B

Graphical network of the top 20 diseases related to Alcohol Dependence:



Diseases related to alcohol dependence

Clinical Features for Alcohol Dependence

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46OMIM
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Clinical features from OMIM:

103780

Clinical synopsis from OMIM:

103780

Drugs & Therapeutics for Alcohol Dependence

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Sources:
5CenterWatch, 41NIH Clinical Center, 6ClinicalTrials, 60UMLS, 40NDF-RT
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Approved drugs:

Search CenterWatch for Alcohol Dependence

Drug clinical trials:

Search ClinicalTrials for Alcohol Dependence

Search NIH Clinical Center for Alcohol Dependence

Search CenterWatch for Alcohol Dependence

Inferred drug relations via UMLS60/NDF-RT40:

Genetic Tests for Alcohol Dependence

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22GTR
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Genetic tests related to Alcohol Dependence:

id Genetic test Affiliating Genes
1 Alcohol Dependence22

Anatomical Context for Alcohol Dependence

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32MalaCards
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MalaCards organs/tissues related to Alcohol Dependence:

32
Brain, Liver, Testes, Pituitary, Amygdala, Cortex, Heart, Prefrontal cortex, Thyroid, Colon, Cerebellum, Prostate, Endothelial

Animal Models for Alcohol Dependence or affiliated genes

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Publications for Alcohol Dependence

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50PubMed
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Articles related to Alcohol Dependence:

(show top 50)    (show all 1251)
idTitleAuthorsYear
1
The role of constraint in the development of nicotine, marijuana, and alcohol dependence in young adulthood. (24343204)
2014
2
The ability of single screening questions for unhealthy alcohol and other drug use to identify substance dependence in primary care. (24411807)
2014
3
Clinical signs of alcohol intoxication and importance of blood alcohol concentration testing in alcohol dependence. (23406180)
2013
4
Baclofen for alcohol-dependence: anticraving or partial substitution? (23422391)
2013
5
Drosophila larvae as a model to study physiological alcohol dependence. (23750304)
2013
6
Pharmacotherapy for alcohol dependence: perceived treatment barriers and action strategies among Veterans Health Administration service providers. (23356858)
2013
7
Replication of genome wide association studies of alcohol dependence: support for association with variation in ADH1C. (23516558)
2013
8
Sex chromosome-wide association analysis suggested male-specific risk genes for alcohol dependence. (23907288)
2013
9
COMT Val158Met modulates the effect of childhood adverse experiences on the risk of alcohol dependence. (22509987)
2013
10
Family-Based Association Analysis of Alcohol Dependence Criteria and Severity. (24015780)
2013
11
Molecular and genetic determinants of alcohol dependence. (24074195)
2013
12
Violent Behavior and Driving under the Influence of Alcohol: Prevalence and Association with Impulsivity among Individuals in Treatment for Alcohol Dependence in Poland. (24356779)
2013
13
Developmental emergence of alcohol use disorder symptoms and their potential as early indicators for progression to alcohol dependence in a high risk sample: a longitudinal study from childhood to early adulthood. (21842966)
2012
14
Hypermethylation of OPRM1 promoter region in European Americans with alcohol dependence. (22914673)
2012
15
Defining the role of baclofen for the treatment of alcohol dependence: a systematic review of the evidence. (22145707)
2012
16
Neuropeptide modulation of central amygdala neuroplasticity is a key mediator of alcohol dependence. (22101113)
2012
17
Functional proteomic analysis reveals sex-dependent differences in structural and energy-producing myocardial proteins in rat model of alcoholic cardiomyopathy. (21245415)
2011
18
Strong association of the alcohol dehydrogenase 1B gene (ADH1B) with alcohol dependence and alcohol-induced medical diseases. (21497796)
2011
19
Is controlled drinking an acceptable goal in the treatment of alcohol dependence? A survey of French alcohol specialists. (21771742)
2011
20
Involvement of orexin in the regulation of stress, depression and reward in alcohol dependence. (21945150)
2011
21
The impact of temperament in the course of alcohol dependence. (21840604)
2011
22
Naltrexone depot formulations for opioid and alcohol dependence: a systematic review. (21554565)
2011
23
Metacognition, emotion, and alcohol dependence in college students: a moderated mediation model. (21420790)
2011
24
Genetics of alcohol dependence. (21507127)
2011
25
Benzodiazepine prescription among patients with severe mental illness and co-occurring alcohol abuse/dependence in Taiwan. (21671270)
2011
26
Self-efficacy change as a mediator of associations between therapeutic bond and one-year outcomes in treatments for alcohol dependence. (21443293)
2011
27
Harmful drinking and alcohol dependence: advice from recent NICE guidelines. (22137411)
2011
28
Glutamate dehydrogenase as a marker of alcohol dependence. (19812241)
2010
29
Comparison of alcohol-dependent patients at a gastroenterological and a psychiatric ward according to the Lesch alcoholism typology: implications for treatment. (20855411)
2010
30
Correlates of and relationship among lifetime alcohol abuse and alcohol dependence in older community residents in Brazil. (20191090)
2009
31
Epidemiology of alcohol abuse and dependence in rural chinese men. (19572979)
2009
32
Serum levels of brain-derived neurotrophic factor in comorbidity of depression and alcohol dependence. (19548207)
2009
33
Family members of people with alcohol or drug dependence: health problems and medical cost compared to family members of people with diabetes and asthma. (19149814)
2009
34
Alcohol abuse and dependence before and after bariatric surgery: a review of the literature and report of a new data set. (18420465)
2008
35
Comorbidity of alcohol and substance dependence with attention-deficit/hyperactivity disorder (ADHD). (18326548)
2008
36
Neurophysiological endophenotypes, CNS disinhibition, and risk for alcohol dependence and related disorders. (17982586)
2007
37
The role of the GABRA2 polymorphism in multiplex alcohol dependence families with minimal comorbidity: within-family association and linkage analyses. (17690794)
2007
38
Influence of the serotonin transporter gene on comorbid disorders among alcohol-dependent individuals. (16691130)
2006
39
No association of dopamine receptor sensitivity in vivo with genetic predisposition for alcoholism and DRD2/DRD3 gene polymorphisms in alcohol dependence. (16759339)
2006
40
Joint analysis of the NACP-REP1 marker within the alpha synuclein gene concludes association with alcohol dependence. (15731118)
2005
41
Serum sialic acid and gamma-glutamyltransferase levels in alcohol-dependent individuals. (15639592)
2004
42
Allelic variation at alcohol metabolism genes ( ADH1B, ADH1C, ALDH2) and alcohol dependence in an American Indian population. (12884000)
2003
43
Association of the gamma-aminobutyric acid A receptor gene cluster with alcohol dependence in Taiwanese Han. (12232773)
2002
44
Novel and previously reported single-nucleotide polymorphisms in the human 5-HT(1B) receptor gene: no association with cocaine or alcohol abuse or dependence. (11496363)
2001
45
Evaluation of alcoholic intoxication depending of the level of brain ethanol-metabolizing enzymes in death from ischemic heart disease]. (11561510)
2001
46
Mu opioid receptor gene variants: lack of association with alcohol dependence. (9399694)
1997
47
Reduced activities of thiamine-dependent enzymes in brains of alcoholics in the absence of Wernicke's encephalopathy. (7485819)
1995
48
Lack of association between alcohol-dependence and D3 dopamine receptor gene in three independent samples. (8825889)
1995
49
Psycho-educational group therapy for alcohol and drug dependence recovery. (21743631)
1993
50
Alcohol dependence and opiate dependence: lack of relationship in mice. (5102945)
1971

Genetic Variations for Alcohol Dependence

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Expression for genes affiliated with Alcohol Dependence

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1BioGPS, 15Gene Expression Omnibus DataSets
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Expression patterns in normal tissues for genes affiliated with Alcohol Dependence

Search GEO for disease gene expression data for Alcohol Dependence.

Pathways for genes affiliated with Alcohol Dependence

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Sources:
53Reactome, 29KEGG, 37NCBI BioSystems Database, 49PharmGKB, 12EMD Millipore
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Pathways related to Alcohol Dependence according to GeneCards/GeneDecks:

(show all 19)
idSuper pathways (with members indented)ScoreTop Affiliating Genes
1
Hide members
11.2HTR1B, HTR2A, DRD2, GABRA6, GABRA2, CHRNA6
2
Hide members
11.2HTR1B, HTR2A, DRD2, GABRA6, GABRA2, CHRNA6
3
Hide members
11.2ADH7, ADH6, ADH1B, ADH1C, ADH4, ADH1A
411.2ALDH2, ADH1A, ADH4, ADH1C, ADH1B, ADH6
5
Hide members
11.2ALDH2, ADH1A, ADH4, ADH1C, ADH1B, ADH6
6
Hide members
11.2ALDH2, ADH1A, ADH4, ADH1C, ADH1B, ADH6
7
Hide members
11.2ALDH2, ADH1A, ADH4, ADH1C, ADH1B, ADH6
8
Hide members
11.2ADH1A, ALDH2, ADH4, ADH1C, ADH1B, ADH7
9
Hide members
11.1ADH1A, ADH4, ADH1C, ADH1B, ADH6, ADH7
10
Hide members
11.1ADH7, ADH6, ADH1B, ADH1C, ADH4, ADH1A
11
Hide members
10.9HTR1B, HTR2A, DRD2, SLC6A4
12
Hide members
10.9GABRA6, GABRA2, CHRNA6, ALDH2
13
Hide members
10.9ALDH2, ADH4, ADH1B, ADH6
1410.8GABRA6, GABRA2, CHRNA6
1510.8ADH1A, ADH1C, ADH1B
16
Hide members
10.8ALDH2, ADH1B, ADH6
1710.7ADH1B, ALDH2
18
Tyrosine metabolism p.1 (dopamine)
Hide members
10.7ADH7, ADH1B
19
Hide members
10.7ADH1B, ADH1A

Compounds for genes affiliated with Alcohol Dependence

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Sources:
44Novoseek, 49PharmGKB, 11DrugBank, 24HMDB, 28IUPHAR, 59Tocris Bioscience, 2BitterDB
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Compounds related to Alcohol Dependence according to GeneCards/GeneDecks:

(show top 50)    (show all 171)
idCompoundScoreTop Affiliating Genes
1ethanol44 49 11 2414.7ANKK1, ALDH2, ADH1C, ADH1B, ADH6, ADH4
2vitamin a44 11 2413.6ALDH2, ADH6, ADH7, ADH1B, ADH1C, ADH4
3nad28 2412.6ALDH2, ADH1A, ADH4, ADH1C, ADH1B, ADH7
4nadh44 11 2413.6ADH1A, ADH7, ADH6, ADH1B, ADH1C, ADH4
5betaine aldehyde44 2412.5ALDH2, ADH1A, ADH1C, ADH1B, ADH6, ADH7
6Nicotinamide-Adenine-Dinucleotide1111.5ADH7, ALDH2, ADH1A, ADH4, ADH1B, ADH1C
7acetaldehyde44 28 2413.5ADH1C, ADH7, ADH1A, ALDH2, ADH6, ADH1B
8choline44 11 2413.5ADH1A, ADH1C, ADH1B, ADH6, ADH7, SLC6A4
9nadph44 2412.4ALDH2, ADH1A, ADH7, ADH1C, ADH1B, ADH6
10dopamine44 28 11 2414.4ADH1B, ALDH2, SLC6A4, HTR2A, DRD2, HTR1B
11risperidone28 44 49 59 11 2416.4SLC6A4, ANKK1, DRD2, HTR2A, HTR1B
12clozapine44 28 49 1114.4DRD2, ANKK1, SLC6A4, HTR1B, HTR2A
13glycerol44 11 2413.4ADH1C, ADH7, ADH6, ADH1B, ADH1A
14maoa4411.3HTR2A, SLC6A4, DRD2, HTR1B
15ketanserin28 4412.3HTR2A, DRD2, SLC6A4, HTR1B
16venlafaxine49 44 11 2414.3SLC6A4, GABRA6, HTR2A, HTR1B
17fluoxetine49 44 28 1114.3HTR1B, DRD2, HTR2A, SLC6A4
18olanzapine49 44 28 11 2415.3HTR1B, HTR2A, DRD2, ANKK1
194-Iodopyrazole1111.2ADH1A, ADH1B, ADH1C
20Fomepizole1111.2ADH1B, ADH1C, ADH1A
21mcpp4411.2SLC6A4, HTR2A, HTR1B
22minaprine44 1112.2HTR2A, SLC6A4, DRD2
23roxindole28 4412.2HTR1B, DRD2, HTR2A
24pindolol44 28 1113.2HTR1B, HTR2A, SLC6A4
25amoxapine44 28 1113.2HTR2A, DRD2, SLC6A4
26terguride28 4412.2HTR2A, HTR1B, DRD2
27ritanserin28 4412.2HTR1B, HTR2A, DRD2
28trimipramine49 44 1113.1DRD2, HTR2A, SLC6A4
29sertindole28 44 1113.1DRD2, HTR1B, HTR2A
30ropinirole44 1112.1HTR2A, HTR1B, DRD2
31lisuride28 44 1113.1HTR2A, HTR1B, DRD2
32ergotamine28 44 1113.1HTR1B, DRD2, HTR2A
33fenfluramine28 44 1113.1HTR1B, SLC6A4, HTR2A
34pergolide28 44 1113.1HTR2A, DRD2, HTR1B
35pramipexole44 49 28 1114.1HTR1B, HTR2A, DRD2
36lorazepam44 49 1113.1DRD2, GABRA6, GABRA2
37asenapine28 1112.1DRD2, HTR2A, HTR1B
38cabergoline28 44 1113.1HTR1B, HTR2A, DRD2
39doxepin44 28 49 1114.0HTR2A, DRD2, SLC6A4
40rsai4410.9ALDH2, ADH1B, ADH1C
415,7-dihydroxytryptamine4410.9SLC6A4, HTR2A
42Cyclohexylformamide1110.9ADH4, ADH1C
43aripiprazole28 49 44 11 2414.9HTR2A, DRD2, HTR1B
44clotiapine4410.9HTR2A, DRD2
45(11c)-n-methylspiperone4410.9HTR2A, DRD2
46bupropion44 49 11 2413.8SLC6A4, DRD2, ANKK1
47ziprasidone49 28 44 1113.8HTR1B, HTR2A, DRD2
48paroxetine44 49 28 1113.7SLC6A4, HTR2A, HTR1B
49l-741,62659 2811.7DRD2, HTR2A
50yohimbine44 28 2 1113.5HTR2A, DRD2, HTR1B

GO Terms for genes affiliated with Alcohol Dependence

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16Gene Ontology
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Cellular components related to Alcohol Dependence according to GeneCards/GeneDecks:

idNameGO IDScoreTop Affiliating Genes
1integral to plasma membraneGO:00588711.1SLC6A4, NRXN3, GABRA6, DRD2, HTR2A, HTR1B

Biological processes related to Alcohol Dependence according to GeneCards/GeneDecks:

(show all 14)
idNameGO IDScoreTop Affiliating Genes
1ethanol oxidationGO:00606911.5ADH7, ALDH2, ADH1A, ADH4, ADH1C, ADH1B
2xenobiotic metabolic processGO:00680511.5ALDH2, ADH1A, ADH4, ADH1C, ADH1B, ADH6
3synaptic transmissionGO:00726811.4HTR1B, HTR2A, GABRA6, GABRA2, NRXN3, CHRNA6
4small molecule metabolic processGO:04428111.3ALDH2, ADH1A, ADH4, ADH1C, ADH1B, ADH6
5regulation of dopamine secretionGO:01405911.1HTR1B, HTR2A, DRD2, CHRNA6
6alcohol metabolic processGO:00606611.0ALDH2, ADH1A, ADH4
7negative regulation of synaptic transmission, glutamatergicGO:05196711.0DRD2, HTR2A, HTR1B
8response to ethanolGO:04547110.9HTR1B, ADH6, ADH7
9ethanol catabolic processGO:00606810.9ALDH2, ADH7
10regulation of behaviorGO:05079510.7HTR1B, HTR2A
11G-protein coupled receptor internalizationGO:00203110.7HTR1B, DRD2
12retinol metabolic processGO:04257210.7ADH7, ADH4
13temperature homeostasisGO:00165910.6DRD2, HTR2A
14vasoconstrictionGO:04231010.4SLC6A4, HTR1B

Molecular functions related to Alcohol Dependence according to GeneCards/GeneDecks:

(show all 8)
idNameGO IDScoreTop Affiliating Genes
1alcohol dehydrogenase (NAD) activityGO:00402211.2ADH7, ADH6, ADH1C, ADH4, ADH1A
2alcohol dehydrogenase activity, zinc-dependentGO:00402411.0ADH1A, ADH4, ADH1B, ADH7
3drug bindingGO:00814410.9HTR1B, HTR2A, DRD2
4benzodiazepine receptor activityGO:00850310.7GABRA2, GABRA6
5serotonin bindingGO:05137810.7HTR2A, HTR1B
6GABA-A receptor activityGO:00489010.7GABRA2, GABRA6
7retinol bindingGO:01984110.6ADH4, ADH7
8retinol dehydrogenase activityGO:00474510.4ADH7, ADH4

Products for genes affiliated with Alcohol Dependence

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  • Antibodies
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Sources for Alcohol Dependence

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3CDC
13ExPASy
14FMA
22GTR
23HGMD
24HMDB
25ICD10
26ICD10 via Orphanet
27ICD9CM
28IUPHAR
29KEGG
34MeSH
35MESH via Orphanet
36MGI
39NCIt
40NDF-RT
43NINDS
44Novoseek
46OMIM
47OMIM via Orphanet
50PubMed
51QIAGEN
57SNOMED-CT via Orphanet
60UMLS
61UMLS via Orphanet