MCID: ALC007
MIFTS: 59

Alcohol Dependence malady

Mental diseases category
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Summaries for Alcohol Dependence

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Wikipedia:65 Alcohol dependence is a substance-related disorder in which an individual is physically or... more...

MalaCards based summary: Alcohol Dependence, also known as alcoholic intoxication, chronic, is related to conduct disorder and alcohol abuse, and has symptoms including An important gene associated with Alcohol Dependence is GABRA2 (gamma-aminobutyric acid (GABA) A receptor, alpha 2), and among its related pathways are ethanol degradation II and Selective Serotonin Reuptake Inhibitor Pathway, Pharmacodynamics. The drugs chlordiazepoxide and citalopram and the compounds (tfmpp) and sb 224289 have been mentioned in the context of this disorder. Affiliated tissues include brain, liver and testes.

Description from OMIM:46 103780

Aliases & Classifications for Alcohol Dependence

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Alcohol Dependence, Aliases & Descriptions:

Name: Alcohol Dependence 8 22 46 10
 
Alcoholic Intoxication, Chronic 62


Classifications:

Malacards categories (disease lists): (See all malacards categories)
Anatomical: Mental diseases


External Ids:

Disease Ontology8 DOID:0050741
OMIM46 103780

Related Diseases for Alcohol Dependence

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Diseases related to Alcohol Dependence via text searches within MalaCards or GeneCards/GeneDecks gene sharing:

(show top 50)    (show all 77)
idRelated DiseaseScoreTop Affiliating Genes
1conduct disorder31.5GABRA2
2alcohol abuse31.4ALDH2, ADH1C
3antisocial personality disorder31.3HTR1B, ANKK1, HTR2A, GABRA6
4nicotine dependence31.2TAS2R16, CHRNA6, ANKK1, NRXN3
5alcohol dependence, protection against31.0ADH1B, ADH1C
6attention deficit hyperactivity disorder30.9HTR2A, HTR1B
7obsessive-compulsive disorder30.7HTR2A, HTR1B
8substance abuse30.7ALDH2, ADH1B, ADH4
9alcoholic liver cirrhosis30.7ADH1C, ADH1B, ALDH2
10liver cirrhosis30.3ALDH2, ADH1B, ADH1C
11blindness10.6
12fetal alcohol spectrum disorder10.6ADH1B
13heroin dependence10.6ANKK1
14schizophrenia10.5
15personality disorder10.5
16tongue squamous cell carcinoma10.5ALDH2, ADH1B
17alcoholic pancreatitis10.5ALDH2, ADH1B, ADH1C
18liver disease10.5
19acute pancreatitis10.4ADH1B, ALDH2, ADH1C
20esophageal cancer10.4ADH1B, ALDH2, ADH4
21pancreatitis, chronic10.4ADH1C, ALDH2, ADH1B
22bipolar disorder10.4
23alexithymia10.4
24anxiety disorder10.4
25drug dependence10.4
26pancreatitis10.4ADH1C, ALDH2, ADH1B
27bulimia nervosa10.4HTR2A, HTR1B
28galactosemia10.4ADH1B, ALDH2, ADH4
29hepatitis10.3
30post-traumatic stress disorder10.3
31cocaine abuse10.3
32substance dependence10.3
33cocaine dependence10.2
34pathological gambling10.2
35neuronitis10.2
36opiate dependence10.2
37major depressive disorder10.1
38obesity10.1
39cannabis dependence10.1
40dystonia10.1
41mood disorder10.1
42periodontitis10.1
43psychotic disorder10.1
44thyroiditis10.1
45myoclonus-dystonia10.1
46myoclonus10.1
47hangover10.1
48alcoholic hepatitis10.0
49diabetes mellitus10.0
50type 2 diabetes mellitus10.0

Graphical network of the top 20 diseases related to Alcohol Dependence:



Diseases related to alcohol dependence

Symptoms for Alcohol Dependence

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Symptoms by clinical synopsis from OMIM:

103780

Clinical features from OMIM:

103780

HPO human phenotypes related to Alcohol Dependence:

id Description Frequency HPO Source Accession
1 abnormality of the nervous system HP:0000707

Drugs & Therapeutics for Alcohol Dependence

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Genetic Tests for Alcohol Dependence

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Genetic tests related to Alcohol Dependence:

id Genetic test Affiliating Genes
1 Alcohol Dependence22

Anatomical Context for Alcohol Dependence

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MalaCards organs/tissues related to Alcohol Dependence:

32
Brain, Liver, Testes, Pituitary, Cortex, Amygdala, Prefrontal cortex, Heart, Thyroid, Cerebellum, Prostate, Neutrophil

Animal Models for Alcohol Dependence or affiliated genes

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Publications for Alcohol Dependence

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Articles related to Alcohol Dependence:

(show top 50)    (show all 934)
idTitleAuthorsYear
1
Prevalence of and Potential Influencing Factors for Alcohol Dependence in Europe. (25342593)
2014
2
The role of constraint in the development of nicotine, marijuana, and alcohol dependence in young adulthood. (24343204)
2014
3
Pavlovian-to-Instrumental Transfer in Alcohol Dependence: A Pilot Study. (25359491)
2014
4
Safety and drinking outcomes among patients with comorbid alcohol dependence and borderline personality disorder treated with high-dose baclofen: a comparative cohort study. (25356633)
2014
5
Sodium oxybate: a review of its use in alcohol withdrawal syndrome and in the maintenance of abstinence in alcohol dependence. (24307430)
2014
6
Severity of alcohol dependence in the Swedish adult population: association with consumption and social factors. (23084032)
2013
7
Effects of family history of alcohol dependence on the subjective response to alcohol using the intravenous alcohol clamp. (23895557)
2013
8
Exploring the genetic architecture of alcohol dependence in African-Americans via analysis of a genomewide set of common variants. (24297757)
2013
9
Rare SERINC2 variants are specific for alcohol dependence in individuals of European descent. (23778322)
2013
10
A double-blind, placebo-controlled trial assessing the efficacy of varenicline tartrate for alcohol dependence. (23728065)
2013
11
Case-control association analysis of Dopamine receptor polymorphisms in alcohol dependence: a pilot study in Indian males. (24135011)
2013
12
Adjunctive aripiprazole therapy with escitalopram in patients with co-morbid major depressive disorder and alcohol dependence: clinical and neuroimaging evidence. (23325372)
2013
13
Authors' reply to Rolland et al.: "Management of alcohol dependence in patients with liver disease". (23999972)
2013
14
A randomised, double-blind, placebo-controlled, efficacy study of nalmefene, as-needed use, in patients with alcohol dependence. (23562264)
2013
15
Evaluation of Relationships among Occupational Stress, Alcohol Dependence and Other Factors in Male Personnel in a Japanese Local Fire Fighting Organization. (24031141)
2012
16
Early-onset alcohol dependence increases the acoustic startle reflex. (22273252)
2012
17
Assessment and management of alcohol dependence and withdrawal in the acute hospital: concise guidance. (22783781)
2012
18
Cannabinoid receptor 1 gene is associated with alcohol dependence. (22085192)
2012
19
The impact of contingency management on quality of life among cocaine abusers with and without alcohol dependence. (22211346)
2012
20
Serum NPY and BNDF response to a behavioral stressor in alcohol-dependent and healthy control participants. (21796371)
2011
21
Alcohol-induced persistent mild cognitive impairment with successful withdrawal from alcohol dependence--a case report. (21675042)
2011
22
Limited associations of dopamine system genes with alcohol dependence and related traits in the Irish Affected Sib Pair Study of Alcohol Dependence (IASPSAD). (21083670)
2011
23
Gabapentin combined with naltrexone for the treatment of alcohol dependence. (21454917)
2011
24
Lack of association between SNPs in the NEUROD2 gene and alcohol dependence in a German patient sample. (20880594)
2011
25
Extended telephone-based continuing care for alcohol dependence: 24-month outcomes and subgroup analyses. (21545667)
2011
26
A randomized, controlled study of treatment for alcohol dependence in patients awaiting liver transplantation. (21506242)
2011
27
Prodynorphin CpG-SNPs associated with alcohol dependence: elevated methylation in the brain of human alcoholics. (21521424)
2011
28
HIV, alcohol dependence, and the criminal justice system: a review and call for evidence-based treatment for released prisoners. (21171933)
2011
29
'For debate': NICE but needy: English guidance on managing alcohol dependence is not backed up by government alcohol policy. (21949191)
2011
30
Comorbid psychiatric diagnoses among individuals presenting to an addiction treatment program for alcohol dependence. (21303253)
2011
31
Do premorbid predictors of alcohol dependence also predict the failure to recover from alcoholism? (20731973)
2010
32
A double-blind, placebo-controlled study of sertraline with naltrexone for alcohol dependence. (18644685)
2009
33
Predicting the effect of naltrexone and acamprosate in alcohol-dependent patients using genetic indicators. (19523047)
2009
34
MAOA-uVNTR polymorphism may modify the protective effect of ALDH2 gene against alcohol dependence in antisocial personality disorder. (19302089)
2009
35
Correlates of and relationship among lifetime alcohol abuse and alcohol dependence in older community residents in Brazil. (20191090)
2009
36
Alcohol dependence and polymorphisms of serotonin-related genes: association studies. (18405071)
2008
37
GABA-A2 receptor subunit gene (GABRA2) polymorphisms and risk for alcohol dependence. (17207817)
2008
38
Family-based association analyses of alcohol dependence phenotypes across DRD2 and neighboring gene ANKK1. (17850642)
2007
39
Diplotypes of the human serotonin 1B receptor promoter predict growth hormone responses to sumatriptan in abstinent alcohol-dependent men. (17217931)
2007
40
Association of alcohol dehydrogenase genes with alcohol dependence: a comprehensive analysis. (16571603)
2006
41
A joint genomewide linkage analysis of symptoms of alcohol dependence and conduct disorder. (17117961)
2006
42
Effect of ethanol on hypothalamic-pituitary-adrenal system response to psychosocial stress in sons of alcohol-dependent fathers. (15100697)
2004
43
Association of functional opioid receptor genotypes with alcohol dependence in Koreans. (15252283)
2004
44
Investigation of DUSP8 and CALCA in alcohol dependence. (13129832)
2003
45
Pharmacological mechanisms of naltrexone and acamprosate in the prevention of relapse in alcohol dependence. (14972776)
2003
46
Association between variants at the GABAAbeta2, GABAAalpha6 and GABAAgamma2 gene cluster and alcohol dependence in a Scottish population. (10578235)
1999
47
Human mu-opioid receptor variation and alcohol dependence. (9884158)
1998
48
Meta-analysis of the effects of alcohol dehydrogenase genotype on alcohol dependence and alcoholic liver disease. (9373704)
1997
49
Long-term observation of the hypothalamic-pituitary-thyroid (HPT) axis in alcohol-dependent patients. (8831864)
1996
50
Dopamine D1, D2 and D3 receptor genes in alcohol dependence. (8750359)
1995

Variations for Alcohol Dependence

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Clinvar genetic disease variations for Alcohol Dependence:

6
id Gene Name Type Significance SNP ID Assembly Location
1ADH1CNM_000669.4(ADH1C): c.815G> A (p.Arg272Gln)single nucleotide variantprotectivers1693482GRCh37Chr 4, 100263965: 100263965
2ADH1CNM_000669.4(ADH1C): c.1048A> G (p.Ile350Val)single nucleotide variantprotectivers698GRCh37Chr 4, 100260789: 100260789
3ADH1BNM_000668.5(ADH1B): c.143A= (p.His48=)single nucleotide variantprotectivers1229984GRCh37Chr 4, 100239319: 100239319
4ADH1BNM_000668.5(ADH1B): c.1108C> T (p.Arg370Cys)single nucleotide variantprotectivers2066702GRCh37Chr 4, 100229017: 100229017
5ALDH2NM_000690.3(ALDH2): c.1510G> A (p.Glu504Lys)single nucleotide variantdrug response, protectivers671GRCh37Chr 12, 112241766: 112241766

Expression for genes affiliated with Alcohol Dependence

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Expression patterns in normal tissues for genes affiliated with Alcohol Dependence

Search GEO for disease gene expression data for Alcohol Dependence.

Pathways for genes affiliated with Alcohol Dependence

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Pathways related to Alcohol Dependence according to GeneCards/GeneDecks:

(show all 16)
idSuper pathways (with members indented)ScoreTop Affiliating Genes
1
Show member pathways
acetate conversion to acetyl-CoA37
oxidative ethanol degradation III37
ethanol degradation IV37
10.3ADH1B, ALDH2
210.3HTR1B, HTR2A
3
Show member pathways
10.3GABRA2, GABRA6
4
Show member pathways
10.2GABRA2, GABRA6, NRXN3
510.2GABRA2, GABRA6, CHRNA6
610.2ADH1B, ADH1A, ADH1C
7
Show member pathways
10.1GABRA2, GABRA6, ALDH2, CHRNA6
8
Show member pathways
10.1ADH1B, ADH1A, ADH4, ADH1C
9
Show member pathways
10.0CHRNA6, HTR2A, HTR1B, GABRA6, GABRA2
10
Show member pathways
mitochondrial L-carnitine shuttle pathway37
Saturated fatty acid biosynthesis60
10.0ALDH2, ADH1B, ADH1A, ADH4, ADH1C
11
Show member pathways
phenylalanine utilization37
noradrenaline and adrenaline degradation37
phenylalanine degradation IV37
10.0ADH1C, ADH4, ADH1A, ADH1B, ALDH2
12
Show member pathways
10.0ADH1C, ADH4, ADH1A, ADH1B, ALDH2
13
Show member pathways
10.0ADH1C, ADH4, ADH1A, ADH1B, ALDH2
14
Show member pathways
glycolysis37
gluconeogenesis37
Glycolysis and Gluconeogenesis37
10.0ADH1C, ADH4, ADH1A, ADH1B, ALDH2
15
Show member pathways
10.0ALDH2, ADH1B, ADH1A, ADH4, ADH1C
16
Show member pathways
9.9CHRNA6, HTR2A, HTR1B, GABRA6, GABRA2, TAS2R16

Compounds for genes affiliated with Alcohol Dependence

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Compounds related to Alcohol Dependence according to GeneCards/GeneDecks:

(show top 50)    (show all 124)
idCompoundScoreTop Affiliating Genes
1(tfmpp)4410.7HTR2A, HTR1B
2sb 2242892810.7HTR2A, HTR1B
3cgs-120662810.7HTR1B, HTR2A
41-(2,5-dimethoxy-4-iodophenyl)-2-aminopropane4410.7HTR2A, HTR1B
5pipamperone28 4411.7HTR1B, HTR2A
6[3h]muscimol2810.7GABRA6, GABRA2
7[11c]flumazenil2810.6GABRA2, GABRA6
8gabazine2810.6GABRA2, GABRA6
9rsai4410.6ALDH2, ADH1C, ADH1B
10[3h]cgs82162810.6GABRA6, GABRA2
119-oh-risperidone2810.6HTR2A, HTR1B
125alpha-pregnan-3alpha-ol-20-one2810.6GABRA2, GABRA6
13venlafaxine44 50 24 1113.6GABRA6, HTR1B, HTR2A
143,4-Dihydroxyphenylglycol2410.6ADH1A, ADH1C, ADH1B
159-cis-Retinal2410.6ADH1A, ADH1B, ADH1C
16[35s]tbps2810.6GABRA2, GABRA6
17Retinal2410.6ADH1B, ADH1A, ADH1C
183,4-Dihydroxymandelaldehyde2410.6ADH1B, ADH1C, ADH1A
19Gamma-Aminobutyric acid2410.6GABRA2, GABRA6, ALDH2
20ro1545132810.6GABRA2, GABRA6
21s330842810.6HTR1B, HTR2A
22risperidone44 50 28 61 24 1115.6HTR2A, ANKK1, HTR1B
23[18f]fluoroethylflumazenil2810.6GABRA6, GABRA2
241-Hexanol2410.6ADH4, ADH1A, ADH1B
25Propyl alcohol2410.6ADH4, ADH1B, ADH1A
261-Pentanol2410.6ADH1A, ADH4, ADH1B
27cyanopindolol44 2811.6HTR1B, HTR2A
28Isobutanol2410.6ADH1B, ADH4, ADH1A
29Isopropyl alcohol2410.6ADH1B, ADH1A, ADH4
301-Butanol2410.6ADH1B, ADH4, ADH1A
31sb 2166412810.6HTR1B, HTR2A
32[3h]gabazine2810.5GABRA6, GABRA2
33betaine aldehyde44 2411.5ALDH2, ADH1B, ADH1C, ADH1A
343a,7a-Dihydroxy-5b-cholestan-26-al2410.5ADH1B, ADH1C, ADH1A, ALDH2
35acetaldehyde28 44 2412.5ADH1C, ADH1A, ADH1B, ALDH2
36bretazenil28 4411.5GABRA2, GABRA6
37tetrahydrodeoxycorticosterone28 4411.5GABRA2, GABRA6
38NADP2410.5ALDH2, ADH1A, ADH1C, ADH1B
39flumazenil28 44 1112.4GABRA6, GABRA2
40olanzapine44 50 28 24 1114.4HTR1B, HTR2A, ANKK1
41vitamin a44 24 1112.4ADH1C, ALDH2, ADH1B, ADH1A, ADH4
42nad28 2411.4ALDH2, ADH1B, ADH1A, ADH4, ADH1C
43naratriptan44 28 1112.4HTR1B, HTR2A
44nadh44 24 1112.4ADH4, ADH1A, ADH1C, ALDH2, ADH1B
45tfmpp2810.4HTR1B, HTR2A
46ethanol44 50 24 1113.3ADH1C, ALDH2, ADH4, ADH1A, ADH1B, ANKK1
47donitriptan2810.3HTR2A, HTR1B
48brl-155722810.3HTR2A, HTR1B
49gr-1279352810.2HTR2A, HTR1B
50isoguvacine2810.0GABRA6, GABRA2

GO Terms for genes affiliated with Alcohol Dependence

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Cellular components related to Alcohol Dependence according to GeneCards/GeneDecks:

idNameGO IDScoreTop Affiliating Genes
1postsynaptic membraneGO:04521110.2GABRA2, GABRA6, CHRNA6

Biological processes related to Alcohol Dependence according to GeneCards/GeneDecks:

(show all 8)
idNameGO IDScoreTop Affiliating Genes
1alcohol metabolic processGO:00606610.3ADH4, ADH1A, ALDH2
2gamma-aminobutyric acid signaling pathwayGO:00721410.3GABRA2, GABRA6
3regulation of dopamine secretionGO:01405910.3CHRNA6, HTR2A, HTR1B
4negative regulation of synaptic transmission, glutamatergicGO:05196710.2HTR2A, HTR1B
5ethanol oxidationGO:00606910.2ALDH2, ADH1B, ADH1A, ADH4, ADH1C
6synaptic transmissionGO:00726810.1GABRA2, ALDH2, HTR2A, CHRNA6
7xenobiotic metabolic processGO:00680510.1ALDH2, ADH1B, ADH1A, ADH4, ADH1C
8regulation of behaviorGO:05079510.0HTR1B, HTR2A

Molecular functions related to Alcohol Dependence according to GeneCards/GeneDecks:

(show all 7)
idNameGO IDScoreTop Affiliating Genes
1benzodiazepine receptor activityGO:00850310.4GABRA2, GABRA6
2alcohol dehydrogenase activity, zinc-dependentGO:00402410.3ADH1B, ADH1A, ADH4
3serotonin bindingGO:05137810.3HTR2A, HTR1B
4extracellular ligand-gated ion channel activityGO:00523010.3GABRA2, GABRA6
5alcohol dehydrogenase (NAD) activityGO:00402210.3ADH1A, ADH4, ADH1C
6serotonin receptor activityGO:00499310.2HTR1B, HTR2A
7GABA-A receptor activityGO:00489010.0GABRA2, GABRA6

Products for genes affiliated with Alcohol Dependence

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Sources for Alcohol Dependence

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3CDC
13ExPASy
14FMA
22GTR
23HGMD
24HMDB
25ICD10
26ICD10 via Orphanet
27ICD9CM
28IUPHAR
29KEGG
34MeSH
35MESH via Orphanet
36MGI
39NCIt
40NDF-RT
43NINDS
44Novoseek
46OMIM
47OMIM via Orphanet
51PubMed
52QIAGEN
58SNOMED-CT via Orphanet
62UMLS
63UMLS via Orphanet