MCID: ALC007
MIFTS: 63

Alcohol Dependence malady

Categories: Genetic diseases, Mental diseases, Cancer diseases

Aliases & Classifications for Alcohol Dependence

Aliases & Descriptions for Alcohol Dependence:

Name: Alcohol Dependence 54 12 29 14
Alcoholism 12 52 14
Alcohol Dependence, Protection Against 54 13
Pharyngeal Neoplasms 42 69
Alcoholic Intoxication, Chronic 69

Classifications:



External Ids:

OMIM 54 103780
Disease Ontology 12 DOID:0050741
MeSH 42 D010610
NCIt 47 C3325
SNOMED-CT 64 126685009 95001001
UMLS 69 C0031347

Summaries for Alcohol Dependence

MalaCards based summary : Alcohol Dependence, also known as alcoholism, is related to personality disorder and alcohol abuse, and has symptoms including abnormality of the nervous system An important gene associated with Alcohol Dependence is ADH1B (Alcohol Dehydrogenase 1B (Class I), Beta Polypeptide), and among its related pathways/superpathways are Alcoholism and Cytochrome P450 - arranged by substrate type. The drugs Ethanol and Topiramate have been mentioned in the context of this disorder. Affiliated tissues include brain, liver and testes, and related phenotypes are behavior/neurological and homeostasis/metabolism

Wikipedia : 71 Alcohol dependence is a previous psychiatric diagnosis in which an individual is physically or... more...

Description from OMIM: 103780

Related Diseases for Alcohol Dependence

Diseases related to Alcohol Dependence via text searches within MalaCards or GeneCards Suite gene sharing:

(show top 50) (show all 118)
id Related Disease Score Top Affiliating Genes
1 personality disorder 30.6 ADH1B ALDH2 DRD2 HTR2A MAOA OPRM1
2 alcohol abuse 11.1
3 pharynx cancer 11.0
4 psychotic disorder 10.5
5 intracranial cavernous angioma 10.5 DRD2 SLC6A3 SLC6A4
6 euthyroid sick syndrome 10.5 DRD2 HTR2A SLC6A4
7 18p deletion syndrome 10.5 DRD2 OPRM1 SLC6A3
8 splenic abscess 10.4 DRD2 HTR2A SLC6A3 SLC6A4
9 ornithosis 10.4 DRD2 MAOA SLC6A4
10 waardenburg's syndrome 10.4 DRD2 HTR2A SLC6A4
11 transmitted_by 10.4 DRD2 OPRK1 OPRM1 SLC6A3 SLC6A4
12 adult brainstem astrocytoma 10.4 MAOA OPRK1 SLC6A4
13 colorectal adenocarcinoma 10.4 DRD2 MAOA SLC6A3 SLC6A4
14 kidney pelvis papillary carcinoma 10.4 MAOA OPRK1 SLC6A4
15 neurogenic bladder 10.4 HTR2A MAOA SLC6A4
16 lethal hydranencephaly-diaphragmatic hernia syndrome 10.4 ADH1B ADH1C CYP2E1
17 cytomegalic congenital adrenal hypoplasia 10.4 DRD2 HTR2A MAOA SLC6A4
18 postencephalitic parkinson disease 10.4 DRD2 HTR2A MAOA SLC6A4
19 multiple personality disorder 10.4 HTR2A MAOA NRXN3 SLC6A4
20 strongyloidiasis 10.4 ALDH2 DRD2 MAOA SLC6A3 SLC6A4
21 hereditary multiple exostoses 10.4 DRD2 HTR2A MAOA SLC6A4
22 carotid stenosis 10.4 ALDH2 DRD2 MAOA SLC6A3 SLC6A4
23 nephrogenic adenoma of the urethra 10.4 DRD2 SLC6A3 SLC6A4
24 hypoglycemia 10.4 ADH7 DRD2 OPRK1 OPRM1 SLC6A4
25 chronic conjunctivitis 10.4 DRD2 HTR2A SLC6A3 SLC6A4
26 pyromania 10.4 DRD2 HTR2A MAOA SLC6A3 SLC6A4
27 suppurative periapical periodontitis 10.4 DRD2 OPRK1 OPRM1
28 tinea pedis 10.4 MAOA SLC6A3 SLC6A4
29 mucinous adenocarcinoma 10.4 DRD2 GABRA2 MAOA SLC6A3 SLC6A4
30 hepatitis d 10.4 DRD2 HTR2A MAOA SLC6A3 SLC6A4
31 intrahepatic gall duct cancer 10.4 HTR2A MAOA SLC6A4
32 retinoblastoma 10.4 DRD2 HTR2A MAOA SLC6A3 SLC6A4
33 alcohol-related birth defect 10.4 ADH1B ADH7 ALDH2
34 cervical adenomyoma 10.4 ADH1B ALDH2 CYP2E1
35 benign epilepsy with centrotemporal spikes 10.4 DRD2 HTR2A MAOA SLC6A4
36 hypoglycemic coma 10.4 HTR2A MAOA SLC6A4
37 cecal benign neoplasm 10.4 ALDH2 DRD2 HTR2A MAOA SLC6A3 SLC6A4
38 hemochromatosis, type 2a 10.4 ADH1C DRD2 MAOA SLC6A3
39 alopecia 10.4 ALDH2 ALDH9A1 CYP2E1 DRD2 SLC6A4
40 ellis-van creveld syndrome 10.4 DRD2 HTR2A MAOA SLC6A3 SLC6A4
41 anal fistula 10.4 ADH1B ADH1C ADH4 ALDH2 CYP2E1
42 cholesteatoma 10.4 DRD2 SLC6A3 SLC6A4
43 hepatitis b reinfection following liver transplantation 10.4 HTR2A MAOA SLC6A4
44 paraphilia disorder 10.4 DRD2 HTR2A MAOA NRXN3 SLC6A3 SLC6A4
45 keratosis 10.4 HTR2A MAOA SLC6A4
46 microcephaly 13, primary, autosomal recessive 10.4 DRD2 HTR2A MAOA SLC6A4
47 hypereosinophilic syndrome 10.4 ADH4 DRD2 MAOA OPRK1 OPRM1 SLC6A3
48 brain glioblastoma multiforme 10.4 DRD2 HTR2A SLC6A3 SLC6A4
49 bicipital tenosynovitis 10.4 ADH4 ALDH2
50 nephronophthisis 13 10.4 HTR2A SLC6A4

Graphical network of the top 20 diseases related to Alcohol Dependence:



Diseases related to Alcohol Dependence

Symptoms & Phenotypes for Alcohol Dependence

Symptoms by clinical synopsis from OMIM:

103780

Clinical features from OMIM:

103780

Human phenotypes related to Alcohol Dependence:

32
id Description HPO Frequency HPO Source Accession
1 abnormality of the nervous system 32 HP:0000707

MGI Mouse Phenotypes related to Alcohol Dependence:

44
id Description MGI Source Accession Score Top Affiliating Genes
1 behavior/neurological MP:0005386 10 ADH7 ALDH2 CYP2E1 DRD2 GABRA2 HTR2A
2 homeostasis/metabolism MP:0005376 9.93 ADH1C ADH7 ALDH2 CYP2E1 DRD2 GABRA2
3 integument MP:0010771 9.61 ALDH2 ALDH9A1 DRD2 GABRA2 GATA4 OPRK1
4 nervous system MP:0003631 9.36 OPRK1 OPRM1 SLC6A3 SLC6A4 ADH7 ALDH2

Drugs & Therapeutics for Alcohol Dependence

Drugs for Alcohol Dependence (from DrugBank, HMDB, Dgidb, PharmGKB, IUPHAR, NovoSeek, BitterDB):

(show top 50) (show all 688)
id Name Status Phase Clinical Trials Cas Number PubChem Id
1
Ethanol Approved Phase 4,Phase 3,Phase 2,Phase 1,Early Phase 1 64-17-5 702
2
Topiramate Approved Phase 4,Phase 3,Phase 2,Phase 1,Early Phase 1 97240-79-4 5284627
3
Bupropion Approved Phase 4,Phase 3,Phase 2,Phase 1 34841-39-9, 34911-55-2 444
4
Dopamine Approved Phase 4,Phase 3,Phase 2,Phase 1,Early Phase 1 51-61-6, 62-31-7 681
5
Fluoxetine Approved, Vet_approved Phase 4,Phase 2 54910-89-3 3386
6
Disulfiram Approved Phase 4,Phase 2,Phase 3,Phase 1 97-77-8 3117
7
Acamprosate Approved, Investigational Phase 4,Phase 3,Phase 2,Phase 1 77337-76-9 71158
8
Naltrexone Approved, Investigational, Vet_approved Phase 4,Phase 3,Phase 2,Phase 1,Early Phase 1 16590-41-3 5360515
9
Lamotrigine Approved, Investigational Phase 4,Phase 3 84057-84-1 3878
10
Erythromycin Approved, Vet_approved Phase 4 114-07-8 12560
11
Benzocaine Approved Phase 4,Phase 3,Phase 2,Phase 1 1994-09-7, 94-09-7 2337
12
Nicotine Approved Phase 4,Phase 2,Phase 3,Phase 1,Early Phase 1 54-11-5 942 89594
13
Prazosin Approved Phase 4,Phase 3,Phase 2,Phase 1,Early Phase 1 19216-56-9 4893
14
Histamine Approved, Investigational Phase 4,Phase 3,Phase 2 75614-87-8, 51-45-6 774
15
Baclofen Approved Phase 4,Phase 3,Phase 2,Phase 1 1134-47-0 2284
16
Varenicline Approved, Investigational Phase 4,Phase 2,Phase 3,Phase 1,Early Phase 1 249296-44-4 5310966
17
Cocaine Approved, Illicit Phase 4,Phase 3,Phase 2,Phase 1 50-36-2 5760 446220
18
Amphetamine Approved, Illicit Phase 4,Phase 3,Phase 2 300-62-9 5826 3007
19
Valproic Acid Approved, Investigational Phase 4,Phase 3,Phase 2,Phase 1 99-66-1 3121
20
Gabapentin Approved, Investigational Phase 4,Phase 3,Phase 2 60142-96-3 3446
21
Ondansetron Approved Phase 4,Phase 3,Phase 2,Phase 1 99614-02-5 4595
22
Midazolam Approved, Illicit Phase 4 59467-70-8 4192
23
Propofol Approved, Investigational, Vet_approved Phase 4,Phase 3 2078-54-8 4943
24
Sertraline Approved Phase 4,Phase 2,Phase 1 79617-96-2 68617
25
Methylphenidate Approved, Investigational Phase 4,Early Phase 1 113-45-1 4158
26
Aripiprazole Approved, Investigational Phase 4,Phase 2,Phase 3 129722-12-9 60795
27
Zonisamide Approved, Investigational Phase 4,Phase 3,Phase 2,Phase 1 68291-97-4 5734
28
Citalopram Approved Phase 4,Phase 2,Phase 1 59729-33-8 2771
29
Memantine Approved, Investigational Phase 4,Phase 3,Phase 2 19982-08-2 4054
30
Lorazepam Approved Phase 4,Phase 2,Phase 1 846-49-1 3958
31 Piracetam Approved Phase 4,Phase 3,Phase 2 7491-74-9
32
Paroxetine Approved, Investigational Phase 4,Phase 3 61869-08-7 43815
33
Carbamazepine Approved, Investigational Phase 4 298-46-4 2554
34
Oxazepam Approved Phase 4 604-75-1 4616
35
Sodium oxybate Approved Phase 4 502-85-2 5360545
36
Icodextrin Approved, Investigational Phase 4,Phase 3 337376-15-5
37
Dutasteride Approved, Investigational Phase 4 164656-23-9 152945 6918296
38
Methadone Approved Phase 4,Phase 3,Phase 2,Phase 1 76-99-3 4095
39
Ribavirin Approved Phase 4,Phase 2 36791-04-5 37542
40
Chlorzoxazone Approved Phase 4 95-25-0 2733
41
Buprenorphine Approved, Illicit, Investigational, Vet_approved Phase 4,Phase 3,Phase 2 52485-79-7 40400 644073
42
Guaifenesin Approved, Vet_approved Phase 4,Phase 3,Phase 2,Phase 1 93-14-1 3516
43
Naloxone Approved, Vet_approved Phase 4,Phase 3,Phase 1 465-65-6 5284596
44
Risperidone Approved, Investigational Phase 4,Phase 2 106266-06-2 5073
45
Bleomycin Approved Phase 4,Phase 3 11056-06-7 5360373
46
Desflurane Approved Phase 4 57041-67-5 42113
47
Isoflurane Approved, Vet_approved Phase 4 26675-46-7 3763
48
Neostigmine Approved, Vet_approved Phase 4 59-99-4 4456
49
Rocuronium Approved Phase 4 119302-91-9, 143558-00-3 441290
50
Sevoflurane Approved, Vet_approved Phase 4 28523-86-6 5206

Interventional clinical trials:

(show top 50) (show all 1821)
id Name Status NCT ID Phase
1 Topiramate for Hospitalized Patients With Alcoholism: a 12-week Study Unknown status NCT01135602 Phase 4
2 Fluoxetine and Bupropion to Treat Patients With Depression and Alcoholism Unknown status NCT00449007 Phase 4
3 Antabuse in Severe Alcoholism: an Open Controlled Study Unknown status NCT00431262 Phase 4
4 Trial for the Treatment of Alcohol Dependence Unknown status NCT00120601 Phase 4
5 Safety of Acamprosate for Alcohol Dependence in the Elderly: An Open-Label Study (SAFADIE) Unknown status NCT00655967 Phase 4
6 Treatment of Alcohol Dependence and Comorbid Bipolar Disorder Unknown status NCT01015586 Phase 4
7 Acamprosate vs. Placebo in Bipolar Alcoholics Unknown status NCT00466661 Phase 4
8 Erythromycin Treatment for Readthrough of APC Gene Stop Codon Mutations in Familial Adenomatous Polyposis Unknown status NCT02175914 Phase 4
9 Sertraline Pharmacotherapy for Alcoholism Subtypes Completed NCT00368550 Phase 4
10 Treatment of Patients With Alcoholism and Attention Deficit Disorder Completed NCT00261872 Phase 4
11 Naltrexone Treatment for Alcoholism Completed NCT00000438 Phase 4
12 Managing Alcoholism in People Who Do Not Respond to Naltrexone Completed NCT00115037 Phase 4
13 Individually Adapted Therapy of Alcoholism Completed NCT00317031 Phase 4
14 Behavioral Therapy Plus Naltrexone for Alcoholism Completed NCT00000456 Phase 4
15 Naltrexone Maintenance Treatment of Alcoholism Completed NCT00000450 Phase 4
16 Treatment for Alcoholism and Post-Traumatic Stress Disorder (Naltrexone) Completed NCT00006489 Phase 4
17 Genetic and Brain Mechanisms of Naltrexone's Treatment Efficacy for Alcoholism Completed NCT00920829 Phase 4
18 Tobacco Dependence in Alcoholism Treatment (Nicotine Patch/Naltrexone) Completed NCT00000437 Phase 4
19 Prazosin Alcohol Dependence IVR Study Completed NCT00167687 Phase 4
20 Smoking Cessation in Alcoholism Treatment Completed NCT00000454 Phase 4
21 Citicoline for Alcohol Dependence Completed NCT02074735 Phase 4
22 Study of Aripiprazole in Subjects With Alcoholism Completed NCT00082199 Phase 4
23 Extended-release Naltrexone for Alcohol Dependence in Primary Care Completed NCT00620750 Phase 4
24 Study of Campral (Acamprosate) for Alcohol Dependence in a Family Medicine Clinic Completed NCT00381043 Phase 4
25 Zonisamide vs. Placebo in the Treatment of Alcohol Dependence Completed NCT00595556 Phase 4
26 Identifying Multiple Mechanisms of Change in Alcoholism Treatment Completed NCT01168960 Phase 4
27 Efficacy Study of Memantine Hydrochloride and Escitalopram for the Treatment of Co-Morbid Depression and Alcoholism. Completed NCT00368862 Phase 4
28 A Randomized Clinical Trial of Alcohol Care Management Completed NCT00419315 Phase 4
29 Adjunctive Topiramate for Treatment of Alcohol Dependence in Patients With Bipolar Disorder Completed NCT00572117 Phase 4
30 Naltrexone Treatment of Alcohol Dependence Completed NCT00000452 Phase 4
31 Trial of Seroquel SR for Alcohol Dependence and Comorbid Anxiety Completed NCT00352469 Phase 4
32 Disulfiram Combined With Lorazepam for Alcohol Dependence and Anxiety Disorder Completed NCT00721526 Phase 4
33 Integrative Therapy in Alcoholism Completed NCT00159107 Phase 4
34 Pharmacogenetic Response to Naltrexone For Alcohol Dependence Completed NCT00831272 Phase 4
35 The Effects of Levetiracetam on Alcohol Dependent Subjects Completed NCT00325182 Phase 4
36 Paroxetine for Comorbid Social Anxiety Disorder and Alcoholism Completed NCT00246441 Phase 4
37 Comparative Trial Of Disulfiram, Naltrexone And Acamprosate In The Treatment Of Alcohol Dependence Completed NCT00435435 Phase 4
38 The Effects of Topiramate on Alcohol Use in Alcohol Dependent Subjects Completed NCT00329407 Phase 4
39 Sertraline for Alcohol Dependence and Depression Completed NCT00004554 Phase 4
40 Injectable Versus Oral Naltrexone Treatment of Alcohol Dependence In Serious Mental Illness (SMI) Completed NCT00453804 Phase 4
41 Naltrexone for Relapse Prevention Completed NCT00000442 Phase 4
42 Naltrexone for Bipolar Disorder and Alcohol Dependence Completed NCT00223275 Phase 4
43 Behavior and Naltrexone Treatment for Alcoholics Completed NCT00000449 Phase 4
44 Injectable Naltrexone Treatment of Alcohol Dependence in Serious Mental Illness (SMI) Completed NCT00453609 Phase 4
45 Quetiapine for Bipolar Disorder and Alcohol Dependence Completed NCT00457197 Phase 4
46 High Dose Vitamin B1 to Reduce Abusive Alcohol Use Completed NCT00680121 Phase 4
47 Use of Naltrexone in a Clinical Setting Completed NCT00000445 Phase 4
48 Naltrexone for Early Problem Drinkers Completed NCT00000455 Phase 4
49 Naltrexone Treatment for Alcoholic Women Completed NCT00000448 Phase 4
50 Combination Nicotine Replacement for Alcoholic Smokers Completed NCT00064844 Phase 4

Search NIH Clinical Center for Alcohol Dependence

Inferred drug relations via UMLS 69 / NDF-RT 48 :


Cochrane evidence based reviews: pharyngeal neoplasms

Genetic Tests for Alcohol Dependence

Genetic tests related to Alcohol Dependence:

id Genetic test Affiliating Genes
1 Alcohol Dependence 29

Anatomical Context for Alcohol Dependence

MalaCards organs/tissues related to Alcohol Dependence:

39
Brain, Liver, Testes, Pituitary, Cortex, Amygdala, Prefrontal Cortex

Publications for Alcohol Dependence

Articles related to Alcohol Dependence:

(show top 50) (show all 1123)
id Title Authors Year
1
The dose-effect relationship of baclofen in alcohol dependence: A 1-year cohort study. ( 28517239 )
2017
2
Association of N-Methyl-D-Aspartate receptor 2B Subunit (GRIN2B) polymorphism with earlier age at onset of withdrawal symptoms in Indian alcohol dependent subjects. ( 26771436 )
2017
3
Drinking-reduction goals offer potential to widen the options for measuring and treating alcohol dependence. ( 28456502 )
2017
4
The Validity of the Montgomery-Asberg Depression Rating Scale in an Inpatient Sample with Alcohol Dependence. ( 28421616 )
2017
5
Corrigendum to "Individualized relapse prediction: Personality measures and striatal and insular activity during reward-processing robustly predict relapse" [Drug and Alcohol Dependence 152 (2015) 93-101]. ( 28431752 )
2017
6
From the neurobiological basis of comorbid alcohol dependence and depression to psychological treatment strategies: study protocol of a randomized controlled trial. ( 28454522 )
2017
7
Higher Impulsivity and HIV-Risk Taking Behaviour in Males with Alcohol Dependence Compared to Bipolar Mania: A Pilot Study. ( 28456858 )
2017
8
Clinical Validation of Reduced Alcohol Consumption After Treatment for Alcohol Dependence Using the World Health Organization Risk Drinking Levels. ( 28019652 )
2017
9
Serum NUCB2/nesfatin-1 levels in different stages of alcohol dependence: Is there a relationship with craving? ( 28529367 )
2017
10
Peripheral immune factors are elevated in women with current or recent alcohol dependence and associated with altered mood and memory. ( 28525828 )
2017
11
An endophenotype approach to the genetics of alcohol dependence: a genome wide association study of fast beta EEG in families of African ancestry. ( 28070124 )
2017
12
Sleep waves and recovery from drug and alcohol dependence: Towards a rhythm analysis of sleep in residential treatment. ( 28525781 )
2017
13
Man stops stuttering with alcohol dependence drug. ( 28500247 )
2017
14
Complications after surgical treatment of femoral neck fractures in men with alcohol dependence syndrome: retrospective register analysis of 154 cases. ( 28493039 )
2017
15
Change in non-abstinent WHO drinking risk levels and alcohol dependence: a 3 year follow-up study in the US general population. ( 28456501 )
2017
16
Dorsolateral prefrontal cortex contributes to the impaired behavioral adaptation in alcohol dependence. ( 28491495 )
2017
17
Baclofen Abuse due to Its Hypomanic Effect in Patients with Alcohol Dependence and Comorbid Major Depressive Disorder. ( 28449569 )
2017
18
Mobile phone messaging for illicit drug and alcohol dependence: A systematic review of the literature. ( 28474374 )
2017
19
Heterogeneity of emotional and interpersonal difficulties in alcohol-dependence: A cluster analytic approach. ( 28411505 )
2017
20
Differentiating the Effects of Familial Risk for Alcohol Dependence and Prenatal Exposure to Alcohol on Offspring Brain Morphology. ( 28084631 )
2017
21
Decreased hippocampal translocator protein (18a88kDa) expression in alcohol dependence: a [(11)C]PBR28 PET study. ( 28072413 )
2017
22
Gender Differences in Affects and Craving in Alcohol-Dependence: A Study During Alcohol Detoxification. ( 28060415 )
2017
23
Promoter Polymorphism rs886205 Genotype Interacts With DNA Methylation of the ALDH2 Regulatory Region in Alcohol Dependence. ( 28430929 )
2017
24
Prevalence of pathological gambling in patients with alcohol dependence syndrome attending a tertiary care center in South India. ( 28483101 )
2017
25
Personality Profile and Short-term Treatment Outcome in Patients with Alcohol Dependence: A Study from South India. ( 28515554 )
2017
26
Acute D3 Antagonist GSK598809 Selectively Enhances Neural Response During Monetary Reward Anticipation in Drug and Alcohol Dependence. ( 28042871 )
2017
27
Preserved affective sharing but impaired decoding of contextual complex emotions in alcohol dependence. ( 28092119 )
2017
28
Acute D3 Antagonist GSK598809 Selectively Enhances Neural Response During Monetary Reward Anticipation in Drug and Alcohol Dependence. ( 28496172 )
2017
29
Women with alcohol dependence: A randomized trial of couple versus individual plus couple therapy. ( 27214168 )
2016
30
Incongruent reduction of dopamine transporter availability in different subgroups of alcohol dependence. ( 27537550 )
2016
31
Two-year prognosis after residential treatment for patients with alcohol dependence: three chief guidelines for sobriety in Japan. ( 27540295 )
2016
32
What are Probable Olfactory Markers of Alcohol Dependence? ( 27629826 )
2016
33
Treatment recommendations for schizophrenia, major depression and alcohol dependence and stigmatizing attitudes of the public: results from a German population survey. ( 28032255 )
2016
34
Posttraumatic Stress Disorder and Alcohol Dependence: Epidemiology and Order of Onset. ( 27617659 )
2016
35
Changes in coping behavior in a randomized controlled trial of concurrent treatment for PTSD and alcohol dependence. ( 27930926 )
2016
36
PTSD, alcohol dependence, and conduct problems: Distinct pathways via lability and disinhibition. ( 27619010 )
2016
37
The Genetics of Alcohol Dependence and Alcohol-related Liver Disease. ( 27575312 )
2016
38
Hair ethyl glucuronide and serum carbohydrate deficient transferrin for the assessment of relapse in alcohol-dependent patients. ( 26851349 )
2016
39
"Validation of differential GDAP1 DNA methylation in alcohol dependence and its potential function as a biomarker for disease severity and therapy outcome". ( 27128683 )
2016
40
Authors' Reply to Alain Braillon's Comment on "Safety and Tolerability of Pharmacological Treatment of Alcohol Dependence: Comprehensive Review of Evidence". ( 27503285 )
2016
41
Comparing Three Cognitive Biases for Alcohol Cues in Alcohol Dependence. ( 27651285 )
2016
42
Persistent cannabis dependence and alcohol dependence represent risks for midlife economic and social problems: A longitudinal cohort study. ( 28008372 )
2016
43
Effect of 15% Alcohol Dependence on Alveolar Bone Loss and TNF-I+ Secretion in Wistar Rats. ( 27058374 )
2016
44
An association study revealed substantial effects of dominance, epistasis and substance dependence co-morbidity on alcohol dependence symptom count. ( 27151647 )
2016
45
Association Splitting: A randomized controlled trial of a new method to reduce craving among inpatients with alcohol dependence. ( 27086250 )
2016
46
Impulsivity, implicit attitudes and explicit cognitions, and alcohol dependence as predictors of pathological gambling. ( 27614152 )
2016
47
Reprogramming of mPFC transcriptome and function in alcohol dependence. ( 27657733 )
2016
48
Dissociated Accumbens and Hippocampal Structural Abnormalities across Obesity and Alcohol Dependence. ( 27207916 )
2016
49
Association of the Sweet-Liking Phenotype and Craving for Alcohol With the Response to Naltrexone Treatment in Alcohol Dependence: A Randomized Clinical Trial. ( 27627782 )
2016
50
Using In Vitro Electrophysiology to Screen Medications: Accumbal Plasticity as an Engram of Alcohol Dependence. ( 27055622 )
2016

Variations for Alcohol Dependence

ClinVar genetic disease variations for Alcohol Dependence:

6
id Gene Variation Type Significance SNP ID Assembly Location
1 TAS2R16 NM_016945.2(TAS2R16): c.516T> G (p.Asn172Lys) single nucleotide variant Pathogenic,risk factor rs846664 GRCh37 Chromosome 7, 122635173: 122635173
2 ADH1C NM_000669.4(ADH1C): c.815G> A (p.Arg272Gln) single nucleotide variant protective rs1693482 GRCh37 Chromosome 4, 100263965: 100263965
3 ADH1C NM_000669.4(ADH1C): c.1048A> G (p.Ile350Val) single nucleotide variant protective rs698 GRCh37 Chromosome 4, 100260789: 100260789
4 ADH1B NM_000668.5(ADH1B): c.143A= (p.His48=) single nucleotide variant protective rs1229984 GRCh37 Chromosome 4, 100239319: 100239319
5 ADH1B NM_000668.5(ADH1B): c.1108C> T (p.Arg370Cys) single nucleotide variant protective rs2066702 GRCh37 Chromosome 4, 100229017: 100229017
6 ALDH2 NM_000690.3(ALDH2): c.1510G> A (p.Glu504Lys) single nucleotide variant Pathogenic,protective,risk factor rs671 GRCh37 Chromosome 12, 112241766: 112241766

Copy number variations for Alcohol Dependence from CNVD:

7 (show top 50) (show all 130)
id CNVD ID Chromosom Start End Type Gene Symbol CNVD Disease
1 36180 1 72528018 72610078 Copy number Alcoholism
2 47606 10 95535368 95541692 Copy number LGI1 Alcoholism
3 55510 11 54453381 55222488 Copy number OR4A15 Alcoholism
4 55512 11 54453381 55222488 Copy number OR4A16 Alcoholism
5 55514 11 54453381 55222488 Copy number OR4C11 Alcoholism
6 55516 11 54453381 55222488 Copy number OR4C15 Alcoholism
7 55518 11 54453381 55222488 Copy number OR4C16 Alcoholism
8 55520 11 54453381 55222488 Copy number OR4C6 Alcoholism
9 55522 11 54453381 55222488 Copy number OR4P4 Alcoholism
10 55524 11 54453381 55222488 Copy number OR4S2 Alcoholism
11 55526 11 54453381 55222488 Copy number TRIM48 Alcoholism
12 63522 12 11916630 11919012 Copy number ETV6 Alcoholism
13 66840 12 33192673 33198641 Copy number FGD4 Alcoholism
14 66854 12 33259772 33296621 Copy number Alcoholism
15 78293 13 49964172 49982174 Copy number Alcoholism
16 122036 18 5195228 5200753 Copy number Alcoholism
17 136050 2 126142262 126191901 Copy number Alcoholism
18 137466 2 146561505 146640703 Copy number Alcoholism
19 145118 2 34552819 34590561 Copy number LTBP1 Alcoholism
20 150705 20 1335658 1343793 Copy number Alcoholism
21 150875 20 1506181 1547142 Copy number SIRPB1 Alcoholism
22 153918 20 41704335 41706581 Copy number IFT52 Alcoholism
23 164176 22 35465251 35493026 Copy number RABL4 Alcoholism
24 171099 3 163977466 164291801 Copy number Alcoholism
25 178116 3 68712334 68728352 Copy number Alcoholism
26 178149 3 68811511 68831828 Copy number Alcoholism
27 188748 4 68966876 69572080 Copy number TMPRSS11E Alcoholism
28 188750 4 68966876 69572080 Copy number TMPRSS11E2 Alcoholism
29 188752 4 68966876 69572080 Copy number UGT2B15 Alcoholism
30 188754 4 68966876 69572080 Copy number UGT2B17 Alcoholism
31 200626 5 57344829 57380923 Copy number Alcoholism
32 203890 6 103831330 103898013 Copy number Alcoholism
33 221060 7 142104463 142176424 Copy number PRSS1 Alcoholism
34 221062 7 142104463 142176424 Copy number TRY6 Alcoholism
35 238289 8 32756235 32814875 Copy number Alcoholism
36 245025 9 100343591 100357222 Copy number GABBR2 Alcoholism
37 248888 9 137616644 137620307 Copy number Alcoholism
38 251679 9 31281381 31282431 Copy number Alcoholism
39 258040 X 115046862 115061085 Copy number Alcoholism
40 258686 X 124296874 125546552 Copy number WDR40B Alcoholism
41 258687 X 124296874 125546552 Copy number WDR40C Alcoholism
42 258774 X 126390767 126443595 Copy number Alcoholism
43 258869 X 128284261 128345276 Copy number Alcoholism
44 258955 X 129071647 129072996 Copy number ELF4 Alcoholism
45 259008 X 130387579 130846282 Copy number LOC286467 Alcoholism
46 259009 X 130387579 130846282 Copy number OR13H1 Alcoholism
47 259338 X 134549966 134874484 Copy number CT45A1 Alcoholism
48 259339 X 134549966 134874484 Copy number CT45A2 Alcoholism
49 259340 X 134549966 134874484 Copy number CT45A3 Alcoholism
50 259341 X 134549966 134874484 Copy number CT45A4 Alcoholism

Expression for Alcohol Dependence

Search GEO for disease gene expression data for Alcohol Dependence.

Pathways for Alcohol Dependence

Pathways related to Alcohol Dependence according to KEGG:

37
id Name Kegg Source Accession
1 Alcoholism hsa05034