MCID: ALC007
MIFTS: 65

Alcohol Dependence

Categories: Genetic diseases, Cancer diseases, Mental diseases

Aliases & Classifications for Alcohol Dependence

MalaCards integrated aliases for Alcohol Dependence:

Name: Alcohol Dependence 53 12 72 36 28 14
Alcoholism 53 12 51
Alcohol Dependence, Protection Against 53 13
Pharyngeal Neoplasms 41 69
Alcohol Dependence, Susceptibility to 53
Alcoholic Intoxication, Chronic 69

Characteristics:

OMIM:

53
Inheritance:
probably multifactorial, genetically influenced


Classifications:



External Ids:

OMIM 53 103780
Disease Ontology 12 DOID:0050741
MeSH 41 D010610
NCIt 46 C3325
SNOMED-CT 64 126685009 95001001
MedGen 39 C0001973
KEGG 36 H01611

Summaries for Alcohol Dependence

MalaCards based summary : Alcohol Dependence, also known as alcoholism, is related to fetal alcohol syndrome and alcohol use disorder, and has symptoms including alcoholism An important gene associated with Alcohol Dependence is ADH1B (Alcohol Dehydrogenase 1B (Class I), Beta Polypeptide), and among its related pathways/superpathways are Alcoholism and Peptide ligand-binding receptors. The drugs Acamprosate and Ethanol have been mentioned in the context of this disorder. Affiliated tissues include brain, liver and testes, and related phenotypes are behavior/neurological and homeostasis/metabolism

Wikipedia : 72 Alcohol dependence is a previous psychiatric diagnosis in which an individual is physically or... more...

Description from OMIM: 103780

Related Diseases for Alcohol Dependence

Diseases related to Alcohol Dependence via text searches within MalaCards or GeneCards Suite gene sharing:

(show top 50) (show all 126)
# Related Disease Score Top Affiliating Genes
1 fetal alcohol syndrome 34.8 ADH1B ADH7 ALDH2
2 alcohol use disorder 32.9 ADH1B ALDH2 DRD2 SLC6A4 TAS2R16
3 alcohol abuse 32.7 ALDH2 ALDH9A1 CYP2E1 DRD2 GABRA2 SLC6A4
4 psychotic disorder 31.9 DRD2 HTR2A SLC6A3 SLC6A4
5 anxiety 31.2 HTR2A MAOA SLC6A3 SLC6A4
6 conduct disorder 31.1 ALDH2 DRD2 MAOA SLC6A3 SLC6A4
7 drug dependence 31.1 CHRNA6 DRD2 OPRK1 OPRM1 SLC6A4
8 personality disorder 31.0 ALDH2 DRD2 HTR1B HTR2A MAOA SLC6A3
9 antisocial personality disorder 31.0 ALDH2 DRD2 MAOA SLC6A3 SLC6A4
10 cocaine dependence 30.9 DRD2 OPRK1 OPRM1 SLC6A3 SLC6A4
11 pathological gambling 30.9 DRD2 HTR2A MAOA SLC6A3 SLC6A4
12 schizophrenia 30.9 DRD2 HTR1B HTR2A MAOA SLC6A3 SLC6A4
13 opiate dependence 30.9 DRD2 OPRK1 OPRM1 SLC6A4
14 bipolar disorder 30.9 DRD2 HTR2A MAOA SLC6A3 SLC6A4
15 post-traumatic stress disorder 30.9 DRD2 HTR2A MAOA SLC6A4
16 cocaine abuse 30.8 DRD2 SLC6A3 SLC6A4
17 major depressive disorder 30.8 DRD2 HTR1B HTR2A MAOA SLC6A3 SLC6A4
18 attention deficit-hyperactivity disorder 30.7 DRD2 HTR1B HTR2A MAOA SLC6A3 SLC6A4
19 substance dependence 30.7 ADH4 DRD2 HTR1B MAOA OPRK1 OPRM1
20 disease of mental health 30.6 ADH1B ALDH2 DRD2 HTR2A MAOA OPRM1
21 alcoholic pancreatitis 30.5 ADH1B ALDH2 CYP2E1
22 mood disorder 30.5 DRD2 HTR1B HTR2A MAOA SLC6A4
23 alcoholic liver cirrhosis 30.5 ADH1B ADH1C ADH4 ALDH2 CYP2E1
24 obsessive-compulsive disorder 30.5 DRD2 HTR1B HTR2A MAOA SLC6A3 SLC6A4
25 tobacco addiction 30.4 ALDH2 CHRNA6 DRD2 HTR2A MAOA OPRM1
26 social phobia 30.4 DRD2 MAOA SLC6A4
27 opioid addiction 30.4 DRD2 OPRK1 OPRM1
28 phobic disorder 30.4 MAOA OPRK1 SLC6A4
29 oppositional defiant disorder 30.4 DRD2 MAOA SLC6A3 SLC6A4
30 dysthymic disorder 30.4 HTR2A MAOA SLC6A4
31 agoraphobia 30.4 MAOA OPRK1 SLC6A4
32 generalized anxiety disorder 30.4 DRD2 HTR2A MAOA SLC6A4
33 borderline personality disorder 30.3 HTR1B HTR2A MAOA SLC6A4
34 paranoid schizophrenia 30.3 HTR2A MAOA SLC6A4
35 schizoaffective disorder 30.3 DRD2 HTR2A SLC6A4
36 substance abuse 30.3 DRD2 GABRA2 HTR1B MAOA SLC6A3 SLC6A4
37 panic disorder 29.9 HTR2A MAOA SLC6A4
38 pharynx cancer 11.1
39 alcohol-induced mental disorder 10.8 DRD2 SLC6A3 SLC6A4
40 periodic limb movement disorder 10.8 DRD2 HTR2A SLC6A4
41 bruxism 10.8 DRD2 HTR2A SLC6A4
42 alcoholic psychosis 10.8 DRD2 HTR2A SLC6A3 SLC6A4
43 heroin dependence 10.8 DRD2 OPRM1 SLC6A3
44 tic disorder 10.8 DRD2 HTR2A SLC6A3
45 premature ejaculation 10.8 HTR1B SLC6A3 SLC6A4
46 migraine with aura 10.7 DRD2 HTR1B SLC6A3 SLC6A4
47 methanol poisoning 10.7 ADH1B ADH1C CYP2E1
48 early-onset schizophrenia 10.7 DRD2 HTR2A MAOA SLC6A4
49 brunner syndrome 10.7 HTR1B MAOA SLC6A4
50 alzheimer disease 5 10.7 HTR2A SLC6A4

Graphical network of the top 20 diseases related to Alcohol Dependence:



Diseases related to Alcohol Dependence

Symptoms & Phenotypes for Alcohol Dependence

Symptoms via clinical synopsis from OMIM:

53
Neuro:
alcoholism

Misc:
25 to 50% lifetime risk for sons and brothers of severely alcoholic men


Clinical features from OMIM:

103780

Human phenotypes related to Alcohol Dependence:

31
# Description HPO Frequency HPO Source Accession
1 alcoholism 31 HP:0030955

MGI Mouse Phenotypes related to Alcohol Dependence:

43
# Description MGI Source Accession Score Top Affiliating Genes
1 behavior/neurological MP:0005386 10.1 HTR1B HTR2A ADH7 MAOA ALDH2 OPRK1
2 homeostasis/metabolism MP:0005376 9.93 GATA4 ADH1C ADH7 MAOA ALDH2 OPRK1
3 endocrine/exocrine gland MP:0005379 9.91 HTR1B HTR2A ALDH2 OPRK1 OPRM1 DRD2
4 integument MP:0010771 9.61 ALDH2 OPRK1 ALDH9A1 OPRM1 DRD2 SLC6A3
5 nervous system MP:0003631 9.36 ADH7 MAOA ALDH2 OPRK1 CHRNA6 OPRM1

Drugs & Therapeutics for Alcohol Dependence

Drugs for Alcohol Dependence (from DrugBank, HMDB, Dgidb, PharmGKB, IUPHAR, NovoSeek, BitterDB):

(show top 50) (show all 451)
# Name Status Phase Clinical Trials Cas Number PubChem Id
1
Acamprosate Approved, Investigational Phase 4,Phase 3,Phase 2,Phase 1 77337-76-9 71158
2
Ethanol Approved Phase 4,Phase 2,Phase 3,Phase 1,Early Phase 1 64-17-5 702
3
Topiramate Approved Phase 4,Phase 3,Phase 2,Phase 1,Early Phase 1 97240-79-4 5284627
4
Naltrexone Approved, Investigational, Vet_approved Phase 4,Phase 3,Phase 2,Phase 1,Early Phase 1 16590-41-3 5360515
5
Lamotrigine Approved, Investigational Phase 4,Phase 3 84057-84-1 3878
6
Bupropion Approved Phase 4,Phase 3,Phase 2,Phase 1 34911-55-2, 34841-39-9 444
7
Dopamine Approved Phase 4,Phase 3,Phase 2,Phase 1,Early Phase 1 51-61-6, 62-31-7 681
8
Fluoxetine Approved, Vet_approved Phase 4,Phase 2 54910-89-3 3386
9
Disulfiram Approved Phase 4,Phase 2,Phase 3,Phase 1 97-77-8 3117
10
Prazosin Approved Phase 4,Phase 3,Phase 2,Phase 1,Early Phase 1 19216-56-9 4893
11
Histamine Approved, Investigational Phase 4,Phase 2 51-45-6, 75614-87-8 774
12
Varenicline Approved, Investigational Phase 4,Phase 2,Phase 3,Phase 1,Early Phase 1 249296-44-4 5310966
13
Gabapentin Approved, Investigational Phase 4,Phase 3,Phase 2 60142-96-3 3446
14
Cocaine Approved, Illicit Phase 4,Phase 3,Phase 2,Phase 1 50-36-2 446220 5760
15
Valproic Acid Approved, Investigational Phase 4,Phase 3,Phase 2,Phase 1 99-66-1 3121
16
Ondansetron Approved Phase 4,Phase 2,Phase 3,Phase 1 99614-02-5 4595
17
Zonisamide Approved, Investigational Phase 4,Phase 3,Phase 2,Phase 1 68291-97-4 5734
18
Lorazepam Approved Phase 4,Phase 2,Phase 1 846-49-1 3958
19
Benzocaine Approved, Investigational Phase 4,Phase 3,Phase 2,Phase 1 1994-09-7, 94-09-7 2337
20
Sertraline Approved Phase 4,Phase 2,Phase 1 79617-96-2 68617
21
Nicotine Approved Phase 4,Phase 3,Phase 2,Phase 1,Early Phase 1 54-11-5 89594 942
22
Methylphenidate Approved, Investigational Phase 4,Phase 1,Early Phase 1 20748-11-2, 113-45-1 4158
23
Aripiprazole Approved, Investigational Phase 4,Phase 2,Phase 3 129722-12-9 60795
24
Citalopram Approved Phase 4,Phase 2,Phase 1 59729-33-8 2771
25
Memantine Approved, Investigational Phase 4,Phase 3,Phase 2 19982-08-2 4054
26
Oxazepam Approved Phase 4 604-75-1 4616
27
Sodium oxybate Approved Phase 4 502-85-2 5360545
28 Piracetam Approved, Investigational Phase 4,Phase 3,Phase 2 7491-74-9
29
Paroxetine Approved, Investigational Phase 4,Phase 3 61869-08-7 43815
30
Baclofen Approved Phase 4,Phase 2,Phase 3,Phase 1 1134-47-0 2284
31
Carbamazepine Approved, Investigational Phase 4 298-46-4 2554
32
Dutasteride Approved, Investigational Phase 4 164656-23-9 6918296 152945
33
Icodextrin Approved, Investigational Phase 4 337376-15-5
34
Methadone Approved Phase 4,Phase 2 76-99-3 4095
35
Ribavirin Approved Phase 4,Phase 2 36791-04-5 37542
36
Simvastatin Approved Phase 4 79902-63-9 54454
37
Chlorzoxazone Approved Phase 4 95-25-0 2733
38
Buprenorphine Approved, Illicit, Investigational, Vet_approved Phase 4 52485-79-7 644073 40400
39
Guaifenesin Approved, Investigational, Vet_approved Phase 4,Phase 2 93-14-1 3516
40
Naloxone Approved, Vet_approved Phase 4,Phase 3,Phase 1 465-65-6 5284596
41
Risperidone Approved, Investigational Phase 4,Phase 2 106266-06-2 5073
42
gamma-Aminobutyric acid Approved, Investigational Phase 4,Phase 3,Phase 2 56-12-2 119
43
Acetylcysteine Approved, Investigational Phase 4,Phase 3,Phase 1,Phase 2,Early Phase 1 616-91-1 12035
44
Acetylcholine Approved Phase 4,Phase 2 51-84-3 187
45
Pregabalin Approved, Illicit, Investigational Phase 4,Phase 3,Phase 2 148553-50-8 5486971
46
Heroin Approved, Illicit, Investigational Phase 4,Phase 2,Phase 1 561-27-3 5462328
47
Oxytocin Approved, Vet_approved Phase 4,Phase 3,Phase 2,Phase 1,Early Phase 1 50-56-6 53477758 439302
48
Olanzapine Approved, Investigational Phase 4,Phase 3,Phase 2 132539-06-1 4585
49
Lenograstim Approved, Investigational Phase 4 135968-09-1
50
Pentoxifylline Approved, Investigational Phase 4,Phase 2,Phase 3 6493-05-6 4740

Interventional clinical trials:

(show top 50) (show all 1068)

# Name Status NCT ID Phase Drugs
1 Safety of Acamprosate for Alcohol Dependence in the Elderly: An Open-Label Study (SAFADIE) Unknown status NCT00655967 Phase 4 Acamprosate (Campral);Acamprosate
2 Topiramate for Hospitalized Patients With Alcoholism: a 12-week Study Unknown status NCT01135602 Phase 4 Topiramate
3 Trial for the Treatment of Alcohol Dependence Unknown status NCT00120601 Phase 4 Naltrexone;Acamprosate
4 Treatment of Alcohol Dependence and Comorbid Bipolar Disorder Unknown status NCT01015586 Phase 4 Lamotrigine;Placebo
5 Fluoxetine and Bupropion to Treat Patients With Depression and Alcoholism Unknown status NCT00449007 Phase 4 fluoxetine;bupropion
6 Antabuse in Severe Alcoholism: an Open Controlled Study Unknown status NCT00431262 Phase 4 antabuse (disulfiram)
7 Acamprosate vs. Placebo in Bipolar Alcoholics Unknown status NCT00466661 Phase 4 Acamprosate;Placebo
8 Citicoline for Alcohol Dependence Completed NCT02074735 Phase 4 Placebo;Citicoline
9 Extended-release Naltrexone for Alcohol Dependence in Primary Care Completed NCT00620750 Phase 4 Extended release injectable naltrexone (Vivitrol)
10 Study of Campral (Acamprosate) for Alcohol Dependence in a Family Medicine Clinic Completed NCT00381043 Phase 4 Acamprosate (Campral)
11 Zonisamide vs. Placebo in the Treatment of Alcohol Dependence Completed NCT00595556 Phase 4 zonisamide;Placebo
12 A Randomized Clinical Trial of Alcohol Care Management Completed NCT00419315 Phase 4
13 Trial of Seroquel SR for Alcohol Dependence and Comorbid Anxiety Completed NCT00352469 Phase 4 Seroquel XR
14 Disulfiram Combined With Lorazepam for Alcohol Dependence and Anxiety Disorder Completed NCT00721526 Phase 4 disulfiram plus lorazepam
15 Adjunctive Topiramate for Treatment of Alcohol Dependence in Patients With Bipolar Disorder Completed NCT00572117 Phase 4 Topiramate
16 Identifying Multiple Mechanisms of Change in Alcoholism Treatment Completed NCT01168960 Phase 4
17 Pharmacogenetic Response to Naltrexone For Alcohol Dependence Completed NCT00831272 Phase 4 naltrexone;Placebo
18 Prazosin Alcohol Dependence IVR Study Completed NCT00167687 Phase 4 prazosin
19 Injectable Versus Oral Naltrexone Treatment of Alcohol Dependence In Serious Mental Illness (SMI) Completed NCT00453804 Phase 4 injectable naltrexone;oral naltrexone
20 Sertraline Pharmacotherapy for Alcoholism Subtypes Completed NCT00368550 Phase 4 Sertraline;Placebo
21 Comparative Trial Of Disulfiram, Naltrexone And Acamprosate In The Treatment Of Alcohol Dependence Completed NCT00435435 Phase 4 Disulfiram;Acamprosate;Naltexone
22 Naltrexone for Bipolar Disorder and Alcohol Dependence Completed NCT00223275 Phase 4 Naltrexone
23 Injectable Naltrexone Treatment of Alcohol Dependence in Serious Mental Illness (SMI) Completed NCT00453609 Phase 4 long-lasting injectable naltrexone
24 Genetic and Brain Mechanisms of Naltrexone's Treatment Efficacy for Alcoholism Completed NCT00920829 Phase 4 Drug;Placebo
25 Quetiapine for Bipolar Disorder and Alcohol Dependence Completed NCT00457197 Phase 4 Placebo;Quetiapine
26 Tobacco Dependence in Alcoholism Treatment (Nicotine Patch/Naltrexone) Completed NCT00000437 Phase 4 Naltrexone Tablet and Nicotine Patch;Naltrexone Tablet and Placebo Patch;Placebo Tablet and Nicotine Patch;Placebo Tablet and Placebo Patch
27 Treatment of Patients With Alcoholism and Attention Deficit Disorder Completed NCT00261872 Phase 4 Methylphenidate
28 Managing Alcoholism in People Who Do Not Respond to Naltrexone Completed NCT00115037 Phase 4 Naltrexone;placebo
29 Behavioral Therapy Plus Naltrexone for Alcoholism Completed NCT00000456 Phase 4 naltrexone (Revia)
30 Treatment for Alcoholism and Post-Traumatic Stress Disorder (Naltrexone) Completed NCT00006489 Phase 4 Naltrexone;Placebo
31 Naltrexone Treatment for Alcoholism Completed NCT00000438 Phase 4 naltrexone (Revia)
32 Individually Adapted Therapy of Alcoholism Completed NCT00317031 Phase 4 Acamprosate or Naltrexone
33 Naltrexone Treatment of Alcohol Dependence Completed NCT00000452 Phase 4 naltrexone (Revia)
34 Sertraline for Alcohol Dependence and Depression Completed NCT00004554 Phase 4 naltrexone (Revia);sertraline (Zoloft);Placebo
35 Naltrexone Maintenance Treatment of Alcoholism Completed NCT00000450 Phase 4 Naltrexone Tablet;Matched Placebo Tablet
36 Treatment of Patients Suffering of Alcohol Dependence and Impaired Liver Function With Selincro® As-needed Use Completed NCT02197598 Phase 4 nalmefene
37 Study of Aripiprazole in Subjects With Alcoholism Completed NCT00082199 Phase 4 Aripiprazole;Placebo
38 Smoking Cessation in Alcoholism Treatment Completed NCT00000454 Phase 4 nicotine replacement patch
39 Effectiveness of Naltrexone Versus Placebo to Reduce Craving for Alcohol With Evaluation of Genetic Variability. Completed NCT00366626 Phase 4 Naltrexone;Placebo
40 Efficacy Study of Memantine Hydrochloride and Escitalopram for the Treatment of Co-Morbid Depression and Alcoholism. Completed NCT00368862 Phase 4 Ebixa (memantine hydrochloride);Cipralex (escitalopram)
41 Acamprosate in Alcoholics With Comorbid Anxiety or Depression Completed NCT00330174 Phase 4 Acamprosate
42 The Effects of Topiramate on Alcohol Use in Alcohol Dependent Subjects Completed NCT00329407 Phase 4 Topiramate (Topamax)
43 ALK21-018: Effects of Medisorb® Naltrexone (VIVITROL®) on Alcohol Craving in Treatment-seeking, Alcohol-dependent Adults Completed NCT00511836 Phase 4 VIVITROL 380 mg;Placebo
44 Naltrexone for Relapse Prevention Completed NCT00000442 Phase 4 naltrexone (Revia)
45 Comparative Study of Gamma-hydroxy Butyrate Versus Oxazepam in the Treatment of Alcohol Withdrawal Syndrome Completed NCT02090504 Phase 4 Sodium Oxybate (SMO);Oxazepam
46 The Effects of Levetiracetam on Alcohol Dependent Subjects Completed NCT00325182 Phase 4 Levetiracetam
47 Paroxetine for Comorbid Social Anxiety Disorder and Alcoholism Completed NCT00246441 Phase 4 Paroxetine;Placebo
48 Integrative Therapy in Alcoholism Completed NCT00159107 Phase 4 Acamprosate;Placebo
49 Use of Naltrexone in a Clinical Setting Completed NCT00000445 Phase 4 naltrexone (Revia)
50 Acamprosate Added to Escitalopram and Behavioral Treatment for Comorbid Depression and Alcoholism Completed NCT00452543 Phase 4 acamprosate;escitalopram;Placebo

Search NIH Clinical Center for Alcohol Dependence

Inferred drug relations via UMLS 69 / NDF-RT 47 :


Cochrane evidence based reviews: pharyngeal neoplasms

Genetic Tests for Alcohol Dependence

Genetic tests related to Alcohol Dependence:

# Genetic test Affiliating Genes
1 Alcohol Dependence 28 ADH1B ADH1C GABRA2 HTR2A RCBTB1 TAS2R16

Anatomical Context for Alcohol Dependence

MalaCards organs/tissues related to Alcohol Dependence:

38
Brain, Liver, Testes, Cortex, Pituitary, Lung, Amygdala

Publications for Alcohol Dependence

Articles related to Alcohol Dependence:

(show top 50) (show all 1187)
# Title Authors Year
1
Activation of neural stem cells from quiescence drives reactive hippocampal neurogenesis after alcohol dependence. ( 29378214 )
2018
2
Polygenic Risk Score Prediction of Alcohol Dependence Symptoms Across Population-Based and Clinically Ascertained Samples. ( 29405378 )
2018
3
Effect of Interaction Between Duration of Alcohol Consumption and Alcohol Dependence on Thyroid Function Test: Cross Sectional Observational Study. ( 29371771 )
2018
4
Intestinal dysbiosis and permeability: the yin and yang in alcohol dependence and alcoholic liver disease. ( 29352076 )
2018
5
Nicotine-Use/Smoking Is Associated with the Efficacy of Naltrexone in the Treatment of Alcohol Dependence. ( 29431852 )
2018
6
Effect of electronic brief intervention on uptake of specialty treatment in hospital outpatients with likely alcohol dependence: Pilot randomized trial and qualitative interviews. ( 29306817 )
2018
7
Corneal endothelial alterations in alcohol dependence syndrome. ( 29305345 )
2018
8
The Speed of Progression to Tobacco and Alcohol Dependence: A Twin Study. ( 29427143 )
2018
9
Decoding diagnosis and lifetime consumption in alcohol dependence from grey-matter pattern information. ( 29377059 )
2018
10
Lower limbic metabotropic glutamate receptor 5 availability in alcohol dependence. ( 29348321 )
2018
11
Association of alcohol dehydrogenase 1C gene *1/*2 polymorphism with alcohol Dependence(AD) in Turkey: A meta-analysis. ( 29438797 )
2018
12
Prevalence Estimates of ADHD in a Sample of Inpatients With Alcohol Dependence. ( 29308693 )
2018
13
How do people with homelessness and alcohol dependence cope when alcohol is unaffordable? A comparison of residents of Canadian managed alcohol programs and locally recruited controls. ( 29314309 )
2018
14
Treatment for Alcohol Dependence in Primary Care Compared to Outpatient Specialist Treatment-A Randomized Controlled Trial. ( 29346473 )
2018
15
A Call to Action for Treatment of Comorbid Tobacco and Alcohol Dependence. ( 29261821 )
2018
16
Hepatic, lipid and genetic factors associated with obesity: crosstalk with alcohol dependence? ( 27905213 )
2017
17
Acute D3 Antagonist GSK598809 Selectively Enhances Neural Response During Monetary Reward Anticipation in Drug and Alcohol Dependence. ( 28496172 )
2017
18
Health-related quality of life in alcohol dependence: Similar cross-cultural impact beyond specific drinking habits. ( 28805530 )
2017
19
Promoter Polymorphism rs886205 Genotype Interacts With DNA Methylation of the ALDH2 Regulatory Region in Alcohol Dependence. ( 28430929 )
2017
20
The dose-effect relationship of baclofen in alcohol dependence: A 1-year cohort study. ( 28517239 )
2017
21
Traumatic Experiences, Revictimization and Posttraumatic Stress Disorder in German Inpatients Treated for Alcohol Dependence. ( 28952825 )
2017
22
Association between oxytocin and receptor genetic polymorphisms and aggression in a northern Chinese Han population with alcohol dependence. ( 27818356 )
2017
23
An endophenotype approach to the genetics of alcohol dependence: a genome wide association study of fast beta EEG in families of African ancestry. ( 28070124 )
2017
24
Sleep waves and recovery from drug and alcohol dependence: Towards a rhythm analysis of sleep in residential treatment. ( 28525781 )
2017
25
Corrigendum to "Individualized relapse prediction: Personality measures and striatal and insular activity during reward-processing robustly predict relapse" [Drug and Alcohol Dependence 152 (2015) 93-101]. ( 28431752 )
2017
26
Prevalence of pathological gambling in patients with alcohol dependence syndrome attending a tertiary care center in South India. ( 28483101 )
2017
27
Lack of associations of the opioid receptor mu 1 (OPRM1) A118G polymorphism (rs1799971) with alcohol dependence: review and meta-analysis of retrospective controlled studies. ( 29070014 )
2017
28
Change in non-abstinent WHO drinking risk levels and alcohol dependence: a 3 year follow-up study in the US general population. ( 28456501 )
2017
29
Complications after surgical treatment of femoral neck fractures in men with alcohol dependence syndrome: retrospective register analysis of 154 cases. ( 28493039 )
2017
30
Abnormal intrinsic functional hubs in alcohol dependence: evidence from a voxelwise degree centrality analysis. ( 28814870 )
2017
31
Polymorphisms in PDLIM5 gene are associated with alcohol dependence, type 2 diabetes, and hypertension. ( 27693979 )
2017
32
From the neurobiological basis of comorbid alcohol dependence and depression to psychological treatment strategies: study protocol of a randomized controlled trial. ( 28454522 )
2017
33
Rich club and reward network connectivity as endophenotypes for alcohol dependence: a diffusion tensor imaging study. ( 29280246 )
2017
34
Peripheral immune factors are elevated in women with current or recent alcohol dependence and associated with altered mood and memory. ( 28525828 )
2017
35
Pharmacologically controlled drinking in the treatment of alcohol dependence or alcohol use disorders: a systematic review with direct and network meta-analyses on nalmefene, naltrexone, acamprosate, baclofen and topiramate. ( 28940866 )
2017
36
Benzodiazepine maintenance for alcohol dependence: A case series. ( 29302560 )
2017
37
ALCOHOL DEPENDENCE IN GASTROENTEROLOG YOUTPATIENT ON A PUBLIC HOSPITAL. ( 28954040 )
2017
38
Gender Differences in Affects and Craving in Alcohol-Dependence: A Study During Alcohol Detoxification. ( 28060415 )
2017
39
Higher Impulsivity and HIV-Risk Taking Behaviour in Males with Alcohol Dependence Compared to Bipolar Mania: A Pilot Study. ( 28456858 )
2017
40
Reduced Drinking in Alcohol Dependence Treatment, What Is the Evidence? ( 28934736 )
2017
41
Genetic Contribution to Alcohol Dependence: Investigation of a Heterogeneous German Sample of Individuals with Alcohol Dependence, Chronic Alcoholic Pancreatitis, and Alcohol-Related Cirrhosis. ( 28714907 )
2017
42
Mobile phone messaging for illicit drug and alcohol dependence: A systematic review of the literature. ( 28474374 )
2017
43
Erratum: Meta-Analysis Reveals Significant Association of the 3'-UTR VNTR in SLC6A3 With Alcohol Dependence. ( 28862750 )
2017
44
Cross-generational effects of alcohol dependence in humans on HRAS and TP53 methylation in offspring. ( 28799801 )
2017
45
Motivation to change and factors influencing motivation in alcohol dependence syndrome in a tertiary care hospital. ( 28827865 )
2017
46
Crossmodal processing of emotions in alcohol-dependence and Korsakoff syndrome. ( 28885888 )
2017
47
Suicidal thoughts in persons treated for alcohol dependence: The role of selected demographic and clinical factors. ( 28893411 )
2017
48
Preserved affective sharing but impaired decoding of contextual complex emotions in alcohol dependence. ( 28092119 )
2017
49
Association of N-Methyl-D-Aspartate receptor 2B Subunit (GRIN2B) polymorphism with earlier age at onset of withdrawal symptoms in Indian alcohol dependent subjects. ( 26771436 )
2017
50
Autoscopic Hallucination in Alcohol Dependence Syndrome: A Rare or Missed Phenomenon? ( 28811950 )
2017

Variations for Alcohol Dependence

ClinVar genetic disease variations for Alcohol Dependence:

6
# Gene Variation Type Significance SNP ID Assembly Location
1 ADH1C NM_000669.4(ADH1C): c.815G> A (p.Arg272Gln) single nucleotide variant protective rs1693482 GRCh37 Chromosome 4, 100263965: 100263965
2 ADH1C NM_000669.4(ADH1C): c.1048A> G (p.Ile350Val) single nucleotide variant protective rs698 GRCh37 Chromosome 4, 100260789: 100260789
3 ADH1B NM_000668.5(ADH1B): c.143A= (p.His48=) single nucleotide variant protective rs1229984 GRCh37 Chromosome 4, 100239319: 100239319
4 ADH1B NM_000668.5(ADH1B): c.1108C> T (p.Arg370Cys) single nucleotide variant protective rs2066702 GRCh37 Chromosome 4, 100229017: 100229017
5 ALDH2 NM_000690.3(ALDH2): c.1510G> A (p.Glu504Lys) single nucleotide variant Pathogenic,protective,risk factor rs671 GRCh37 Chromosome 12, 112241766: 112241766
6 TAS2R16 NM_016945.2(TAS2R16): c.516T> G (p.Asn172Lys) single nucleotide variant Pathogenic,risk factor rs846664 GRCh37 Chromosome 7, 122635173: 122635173

Copy number variations for Alcohol Dependence from CNVD:

7 (show top 50) (show all 130)
# CNVD ID Chromosom Start End Type Gene Symbol CNVD Disease
1 36180 1 72528018 72610078 Copy number Alcoholism
2 47606 10 95535368 95541692 Copy number LGI1 Alcoholism
3 55510 11 54453381 55222488 Copy number OR4A15 Alcoholism
4 55512 11 54453381 55222488 Copy number OR4A16 Alcoholism
5 55514 11 54453381 55222488 Copy number OR4C11 Alcoholism
6 55516 11 54453381 55222488 Copy number OR4C15 Alcoholism
7 55518 11 54453381 55222488 Copy number OR4C16 Alcoholism
8 55520 11 54453381 55222488 Copy number OR4C6 Alcoholism
9 55522 11 54453381 55222488 Copy number OR4P4 Alcoholism
10 55524 11 54453381 55222488 Copy number OR4S2 Alcoholism
11 55526 11 54453381 55222488 Copy number TRIM48 Alcoholism
12 63522 12 11916630 11919012 Copy number ETV6 Alcoholism
13 66840 12 33192673 33198641 Copy number FGD4 Alcoholism
14 66854 12 33259772 33296621 Copy number Alcoholism
15 78293 13 49964172 49982174 Copy number Alcoholism
16 122036 18 5195228 5200753 Copy number Alcoholism
17 136050 2 126142262 126191901 Copy number Alcoholism
18 137466 2 146561505 146640703 Copy number Alcoholism
19 145118 2 34552819 34590561 Copy number LTBP1 Alcoholism
20 150705 20 1335658 1343793 Copy number Alcoholism
21 150875 20 1506181 1547142 Copy number SIRPB1 Alcoholism
22 153918 20 41704335 41706581 Copy number IFT52 Alcoholism
23 164176 22 35465251 35493026 Copy number RABL4 Alcoholism
24 171099 3 163977466 164291801 Copy number Alcoholism
25 178116 3 68712334 68728352 Copy number Alcoholism
26 178149 3 68811511 68831828 Copy number Alcoholism
27 188748 4 68966876 69572080 Copy number TMPRSS11E Alcoholism
28 188750 4 68966876 69572080 Copy number TMPRSS11E2 Alcoholism
29 188752 4 68966876 69572080 Copy number UGT2B15 Alcoholism
30 188754 4 68966876 69572080 Copy number UGT2B17 Alcoholism
31 200626 5 57344829 57380923 Copy number Alcoholism
32 203890 6 103831330 103898013 Copy number Alcoholism
33 221060 7 142104463 142176424 Copy number PRSS1 Alcoholism
34 221062 7 142104463 142176424 Copy number TRY6 Alcoholism
35 238289 8 32756235 32814875 Copy number Alcoholism
36 245025 9 100343591 100357222 Copy number GABBR2 Alcoholism
37 248888 9 137616644 137620307 Copy number Alcoholism
38 251679 9 31281381 31282431 Copy number Alcoholism
39 258040 X 115046862 115061085 Copy number Alcoholism
40 258686 X 124296874 125546552 Copy number WDR40B Alcoholism
41 258687 X 124296874 125546552 Copy number WDR40C Alcoholism
42 258774 X 126390767 126443595 Copy number Alcoholism
43 258869 X 128284261 128345276 Copy number Alcoholism
44 258955 X 129071647 129072996 Copy number ELF4 Alcoholism
45 259008 X 130387579 130846282 Copy number LOC286467 Alcoholism
46 259009 X 130387579 130846282 Copy number OR13H1 Alcoholism
47 259338 X 134549966 134874484 Copy number CT45A1 Alcoholism
48 259339 X 134549966 134874484 Copy number CT45A2 Alcoholism
49 259340 X 134549966 134874484 Copy number CT45A3 Alcoholism
50 259341 X 134549966 134874484 Copy number CT45A4 Alcoholism

Expression for Alcohol Dependence

Search GEO for disease gene expression data for Alcohol Dependence.

Pathways for Alcohol Dependence

Pathways related to Alcohol Dependence according to KEGG:

36
# Name Kegg Source Accession
1 Alcoholism hsa05034

Pathways related to Alcohol Dependence according to GeneCards Suite gene sharing:

(show all 24)
# Super pathways Score Top Affiliating Genes
1
Show member pathways
13.47 CHRNA6 DRD2 GABRA2 HTR1B HTR2A OPRK1
2
Show member pathways
13.1 ADH1B ADH1C ADH4 ADH7 ALDH2 CYP2E1
3
Show member pathways
12.9 ALDH2 CHRNA6 GABRA2 MAOA SLC6A3 SLC6A4
4
Show member pathways
12.61 ADH1B ADH1C ADH4 ADH7 ALDH2 ALDH9A1
5
Show member pathways
12.54 ADH1B ADH1C ADH4 ADH7 ALDH2 ALDH9A1
6
Show member pathways
12.1 ADH1B ALDH2 ALDH9A1 CYP2E1 MAOA
7
Show member pathways