ARBD
MCID: ALC001
MIFTS: 25

Alcohol-Related Birth Defect (ARBD) malady

Fetal diseases category
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Summaries for Alcohol-Related Birth Defect

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Disease Ontology:8 A fetal alcohol spectrum disorder that results in damage to organs, bones, or muscles due to prenatal alcohol exposure.

MalaCards based summary: Alcohol-Related Birth Defect, also known as alcohol related birth defect, is related to fetal alcohol spectrum disorder and alcohol dependence. An important gene associated with Alcohol-Related Birth Defect is ADH1B (alcohol dehydrogenase 1B (class I), beta polypeptide), and among its related pathways are Cyclophosphamide Pathway, Pharmacodynamics and Glycolysis and gluconeogenesis short map . The compounds n-benzylformamide and Propyl alcohol have been mentioned in the context of this disorder. Affiliated tissues include bone.

Aliases & Classifications for Alcohol-Related Birth Defect

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Alcohol-Related Birth Defect, Aliases & Descriptions:

Name: Alcohol-Related Birth Defect 8
Alcohol Related Birth Defect 62
 
Arbd 8


Classifications:

Malacards categories (disease lists): (See all malacards categories)
Global: Fetal diseases


External Ids:

Disease Ontology8 DOID:0050668

Related Diseases for Alcohol-Related Birth Defect

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Graphical network of the top 20 diseases related to Alcohol-Related Birth Defect:



Diseases related to alcohol-related birth defect

Symptoms for Alcohol-Related Birth Defect

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Drugs & Therapeutics for Alcohol-Related Birth Defect

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Drug clinical trials:

Search ClinicalTrials for Alcohol-Related Birth Defect

Search NIH Clinical Center for Alcohol-Related Birth Defect

Genetic Tests for Alcohol-Related Birth Defect

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Anatomical Context for Alcohol-Related Birth Defect

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MalaCards organs/tissues related to Alcohol-Related Birth Defect:

32
Bone

Animal Models for Alcohol-Related Birth Defect or affiliated genes

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Publications for Alcohol-Related Birth Defect

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Articles related to Alcohol-Related Birth Defect:

idTitleAuthorsYear
1
ADH2 and CYP2E1 genetic polymorphisms: risk factors for alcohol-related birth defects. (11259352)
2001
2
A multiple-level, comprehensive approach to the prevention of fetal alcohol syndrome (FAS) and other alcohol-related birth defects (ARBD). (8557409)
1995

Variations for Alcohol-Related Birth Defect

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Expression for genes affiliated with Alcohol-Related Birth Defect

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Expression patterns in normal tissues for genes affiliated with Alcohol-Related Birth Defect

Search GEO for disease gene expression data for Alcohol-Related Birth Defect.

Pathways for genes affiliated with Alcohol-Related Birth Defect

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Pathways related to Alcohol-Related Birth Defect according to GeneCards/GeneDecks:

idSuper pathways (with members indented)ScoreTop Affiliating Genes
1
Show member pathways
9.3AKR1A1, ADH1B
2
Show member pathways
glycolysis37
gluconeogenesis37
Glycolysis and Gluconeogenesis37
9.3AKR1A1, ADH1B
3
Show member pathways
tryptophan degradation X (mammalian, via tryptamine)37
2-amino-3-carboxymuconate semialdehyde degradation to glutaryl-CoA37
tryptophan degradation37
glutaryl-CoA degradation37
serotonin degradation37
NAD de novo biosynthesis37
superpathway of melatonin degradation37
tryptophan degradation to 2-amino-3-carboxymuconate semialdehyde37
tryptophan utilization I37
melatonin degradation I37
9.3ADH1B, AKR1A1
49.1CYP2E1, AKR1A1
5
Show member pathways
9.0CYP2E1, ADH1B
6
Show member pathways
acetate conversion to acetyl-CoA37
oxidative ethanol degradation III37
ethanol degradation IV37
9.0ADH1B, CYP2E1
7
Show member pathways
9.0ADH1B, CYP2E1
8
Show member pathways
bupropion degradation37
methylglyoxal degradation III37
nicotine degradation III37
nicotine degradation IV37
9.0ADH1B, CYP2E1
9
Show member pathways
8.5AKR1A1, ADH1B, CYP2E1
10
Show member pathways
8.5CYP2E1, AKR1A1, ADH1B

Compounds for genes affiliated with Alcohol-Related Birth Defect

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Compounds related to Alcohol-Related Birth Defect according to GeneCards/GeneDecks:

(show all 37)
idCompoundScoreTop Affiliating Genes
1n-benzylformamide44 1110.7AKR1A1, ADH1B
2Propyl alcohol249.7ADH1B, AKR1A1
3Isopropyl alcohol249.7ADH1B, AKR1A1
4Isobutanol249.7ADH1B, AKR1A1
51-Pentanol249.7ADH1B, AKR1A1
61-Hexanol249.6ADH1B, AKR1A1
71-Butanol249.6ADH1B, AKR1A1
84-methylpyrazole449.5AKR1A1, CYP2E1
9isopropanol449.5AKR1A1, CYP2E1
10trichloroethylene449.5AKR1A1, CYP2E1
11pyrazole44 1110.5AKR1A1, CYP2E1
12benzyl alcohol44 1110.5CYP2E1, AKR1A1
13nash449.5AKR1A1, CYP2E1
14acetone449.5CYP2E1, AKR1A1
15disulfiram44 50 61 1112.4CYP2E1, AKR1A1
16cimetidine44 28 1111.4AKR1A1, CYP2E1
17polyacrylamide449.4ADH1B, AKR1A1
18epoxide449.4AKR1A1, CYP2E1
19menadione44 24 1111.4AKR1A1, CYP2E1
204-hydroxynonenal44 2410.4CYP2E1, AKR1A1
21nad28 2410.3AKR1A1, ADH1B
22phenobarbital44 28 50 1112.3AKR1A1, CYP2E1
23mspi449.3ADH1B, CYP2E1
24verapamil44 28 50 24 1113.3AKR1A1, CYP2E1
25formaldehyde44 2410.3CYP2E1, AKR1A1
26carbon449.2AKR1A1, CYP2E1
27nadh44 24 1111.2AKR1A1, ADH1B
28creatinine449.1AKR1A1, CYP2E1
29rsai448.9AKR1A1, ADH1B, CYP2E1
30acetaldehyde28 44 2410.9CYP2E1, ADH1B, AKR1A1
31NADP248.9CYP2E1, ADH1B, AKR1A1
32glycerol44 24 1110.9AKR1A1, ADH1B, CYP2E1
33vitamin a44 24 1110.9CYP2E1, ADH1B, AKR1A1
34ethanol44 50 24 1111.9CYP2E1, ADH1B, AKR1A1
35nadph44 249.9CYP2E1, ADH1B, AKR1A1
36dopamine44 28 24 1111.9AKR1A1, ADH1B, CYP2E1
37lactate448.8AKR1A1, CYP2E1

GO Terms for genes affiliated with Alcohol-Related Birth Defect

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Biological processes related to Alcohol-Related Birth Defect according to GeneCards/GeneDecks:

idNameGO IDScoreTop Affiliating Genes
1xenobiotic metabolic processGO:0068059.0ADH1B, CYP2E1

Products for genes affiliated with Alcohol-Related Birth Defect

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  • Antibodies
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  • Lysates

Sources for Alcohol-Related Birth Defect

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3CDC
13ExPASy
14FMA
22GTR
23HGMD
24HMDB
25ICD10
26ICD10 via Orphanet
27ICD9CM
28IUPHAR
29KEGG
34MeSH
35MESH via Orphanet
36MGI
39NCIt
40NDF-RT
43NINDS
44Novoseek
46OMIM
47OMIM via Orphanet
51PubMed
52QIAGEN
58SNOMED-CT via Orphanet
62UMLS
63UMLS via Orphanet