MCID: ALC001
MIFTS: 21

Alcohol-Related Birth Defect malady

Summaries for Alcohol-Related Birth Defect

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Disease Ontology:9 A fetal alcohol spectrum disorder that results in damage to organs, bones, or muscles due to prenatal alcohol exposure.

MalaCards based summary: Alcohol-Related Birth Defect, also known as alcohol related birth defect, is related to fetal alcohol syndrome and fetal alcohol spectrum disorder. An important gene associated with Alcohol-Related Birth Defect is ADH1B (alcohol dehydrogenase 1B (class I), beta polypeptide), and among its related pathways are Cyclophosphamide Pathway, Pharmacodynamics and Glycolysis and gluconeogenesis short map . The compounds n-benzylformamide and Propyl alcohol have been mentioned in the context of this disorder. Affiliated tissues include bone.

Aliases & Classifications for Alcohol-Related Birth Defect

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Alcohol-Related Birth Defect, Aliases & Descriptions:

Name: Alcohol-Related Birth Defect 9
Alcohol Related Birth Defect 60
 
Fetal Alcohol Syndrome 60
Arbd 9


External Ids:

Disease Ontology9 DOID:0050668

Related Diseases for Alcohol-Related Birth Defect

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Graphical network of the top 20 diseases related to Alcohol-Related Birth Defect:



Diseases related to alcohol-related birth defect

Symptoms for Alcohol-Related Birth Defect

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Drugs & Therapeutics for Alcohol-Related Birth Defect

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Drug clinical trials:

Search ClinicalTrials for Alcohol-Related Birth Defect

Search NIH Clinical Center for Alcohol-Related Birth Defect

Genetic Tests for Alcohol-Related Birth Defect

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Anatomical Context for Alcohol-Related Birth Defect

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MalaCards organs/tissues related to Alcohol-Related Birth Defect:

31
Bone

Animal Models for Alcohol-Related Birth Defect or affiliated genes

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Publications for Alcohol-Related Birth Defect

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Articles related to Alcohol-Related Birth Defect:

idTitleAuthorsYear
1
ADH2 and CYP2E1 genetic polymorphisms: risk factors for alcohol-related birth defects. (11259352)
2001
2
A multiple-level, comprehensive approach to the prevention of fetal alcohol syndrome (FAS) and other alcohol-related birth defects (ARBD). (8557409)
1995

Variations for Alcohol-Related Birth Defect

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Expression for genes affiliated with Alcohol-Related Birth Defect

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Search GEO for disease gene expression data for Alcohol-Related Birth Defect.

Pathways for genes affiliated with Alcohol-Related Birth Defect

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Pathways related to Alcohol-Related Birth Defect according to GeneCards Suite gene sharing:

idSuper pathways (with members indented)ScoreTop Affiliating Genes
1
Show member pathways
9.3AKR1A1, ADH1B
2
Show member pathways
glycolysis36
gluconeogenesis36
Glycolysis and Gluconeogenesis36
9.3AKR1A1, ADH1B
3
Show member pathways
tryptophan degradation X (mammalian, via tryptamine)36
2-amino-3-carboxymuconate semialdehyde degradation to glutaryl-CoA36
tryptophan degradation36
glutaryl-CoA degradation36
serotonin degradation36
NAD de novo biosynthesis36
superpathway of melatonin degradation36
tryptophan degradation to 2-amino-3-carboxymuconate semialdehyde36
tryptophan utilization I36
melatonin degradation I36
9.3ADH1B, AKR1A1
49.1AKR1A1, CYP2E1
5
Show member pathways
9.0CYP2E1, ADH1B
6
Show member pathways
acetate conversion to acetyl-CoA36
oxidative ethanol degradation III36
ethanol degradation IV36
9.0ADH1B, CYP2E1
7
Show member pathways
9.0ADH1B, CYP2E1
8
Show member pathways
bupropion degradation36
methylglyoxal degradation III36
nicotine degradation III36
nicotine degradation IV36
9.0CYP2E1, ADH1B
9
Show member pathways
8.5AKR1A1, ADH1B, CYP2E1
10
Show member pathways
8.5AKR1A1, ADH1B, CYP2E1

Compounds for genes affiliated with Alcohol-Related Birth Defect

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Compounds related to Alcohol-Related Birth Defect according to GeneCards Suite gene sharing:

(show all 37)
idCompoundScoreTop Affiliating Genes
1n-benzylformamide43 1210.7AKR1A1, ADH1B
2Propyl alcohol249.7ADH1B, AKR1A1
3Isopropyl alcohol249.7ADH1B, AKR1A1
4Isobutanol249.7ADH1B, AKR1A1
51-Pentanol249.7ADH1B, AKR1A1
61-Hexanol249.6ADH1B, AKR1A1
71-Butanol249.6ADH1B, AKR1A1
84-methylpyrazole439.5AKR1A1, CYP2E1
9isopropanol439.5AKR1A1, CYP2E1
10trichloroethylene439.5AKR1A1, CYP2E1
11pyrazole43 1210.5AKR1A1, CYP2E1
12benzyl alcohol43 1210.5CYP2E1, AKR1A1
13nash439.5AKR1A1, CYP2E1
14acetone439.5CYP2E1, AKR1A1
15disulfiram43 49 59 1212.4CYP2E1, AKR1A1
16cimetidine43 28 1211.4AKR1A1, CYP2E1
17polyacrylamide439.4ADH1B, AKR1A1
18epoxide439.4AKR1A1, CYP2E1
19menadione43 24 1211.4AKR1A1, CYP2E1
204-hydroxynonenal43 2410.4CYP2E1, AKR1A1
21nad28 2410.3AKR1A1, ADH1B
22phenobarbital43 28 49 1212.3AKR1A1, CYP2E1
23mspi439.3ADH1B, CYP2E1
24verapamil43 28 49 24 1213.3AKR1A1, CYP2E1
25formaldehyde43 2410.3CYP2E1, AKR1A1
26carbon439.2AKR1A1, CYP2E1
27nadh43 24 1211.2AKR1A1, ADH1B
28creatinine439.1AKR1A1, CYP2E1
29rsai438.9AKR1A1, ADH1B, CYP2E1
30acetaldehyde28 43 2410.9CYP2E1, ADH1B, AKR1A1
31NADP248.9CYP2E1, ADH1B, AKR1A1
32glycerol43 24 1210.9AKR1A1, ADH1B, CYP2E1
33vitamin a43 24 1210.9CYP2E1, ADH1B, AKR1A1
34ethanol43 49 24 1211.9CYP2E1, ADH1B, AKR1A1
35nadph43 249.9CYP2E1, ADH1B, AKR1A1
36dopamine43 28 24 1211.9AKR1A1, ADH1B, CYP2E1
37lactate438.8AKR1A1, CYP2E1

GO Terms for genes affiliated with Alcohol-Related Birth Defect

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Biological processes related to Alcohol-Related Birth Defect according to GeneCards Suite gene sharing:

idNameGO IDScoreTop Affiliating Genes
1xenobiotic metabolic processGO:00068059.0ADH1B, CYP2E1

Products for genes affiliated with Alcohol-Related Birth Defect

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Sources for Alcohol-Related Birth Defect

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3CDC
13ExPASy
14FMA
22GTR
23HGMD
24HMDB
25ICD10
26ICD10 via Orphanet
27ICD9CM
28IUPHAR
29KEGG
33MeSH
34MESH via Orphanet
35MGI
38NCIt
39NDF-RT
42NINDS
43Novoseek
45OMIM
46OMIM via Orphanet
50PubMed
51QIAGEN
56SNOMED-CT via Orphanet
60UMLS
61UMLS via Orphanet