ARBD
MCID: ALC001
MIFTS: 25

Alcohol-Related Birth Defect (ARBD) malady

Fetal diseases category
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Summaries for Alcohol-Related Birth Defect

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Sources:
8Disease Ontology, 33MalaCards
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Disease Ontology:8 A fetal alcohol spectrum disorder that results in damage to organs, bones, or muscles due to prenatal alcohol exposure.

MalaCards: Alcohol-Related Birth Defect, also known as alcohol related birth defect, is related to fetal alcohol spectrum disorder and fetal alcohol syndrome. An important gene associated with Alcohol-Related Birth Defect is ADH1B (alcohol dehydrogenase 1B (class I), beta polypeptide), and among its related pathways are Cyclophosphamide Pathway, Pharmacodynamics and Glycolysis and gluconeogenesis short map . The compounds n-benzylformamide and Propyl alcohol have been mentioned in the context of this disorder. Affiliated tissues include bone.

Aliases & Classifications for Alcohol-Related Birth Defect

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Sources:
8Disease Ontology, 62UMLS
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Classifications:

Malacards categories (disease lists): (See all malacards categories)
Global: Fetal diseases


Aliases & Descriptions:

alcohol-related birth defect 8
alcohol related birth defect 62
arbd 8


External Ids:

Disease Ontology8 DOID:0050668

Related Diseases for Alcohol-Related Birth Defect

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Sources:
17GeneCards, 18GeneDecks
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Graphical network of the top 20 diseases related to Alcohol-Related Birth Defect:



Diseases related to alcohol-related birth defect

Symptoms for Alcohol-Related Birth Defect

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Drugs & Therapeutics for Alcohol-Related Birth Defect

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Sources:
42NIH Clinical Center, 6ClinicalTrials
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Drug clinical trials:

Search ClinicalTrials for Alcohol-Related Birth Defect

Search NIH Clinical Center for Alcohol-Related Birth Defect

Genetic Tests for Alcohol-Related Birth Defect

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Anatomical Context for Alcohol-Related Birth Defect

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Sources:
33MalaCards
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MalaCards organs/tissues related to Alcohol-Related Birth Defect:

33
Bone

Animal Models for Alcohol-Related Birth Defect or affiliated genes

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Publications for Alcohol-Related Birth Defect

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Sources:
52PubMed
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Articles related to Alcohol-Related Birth Defect:

idTitleAuthorsYear
1
ADH2 and CYP2E1 genetic polymorphisms: risk factors for alcohol-related birth defects. (11259352)
2001
2
A multiple-level, comprehensive approach to the prevention of fetal alcohol syndrome (FAS) and other alcohol-related birth defects (ARBD). (8557409)
1995

Variations for Alcohol-Related Birth Defect

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Expression for genes affiliated with Alcohol-Related Birth Defect

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Sources:
2BioGPS, 15Gene Expression Omnibus DataSets
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Expression patterns in normal tissues for genes affiliated with Alcohol-Related Birth Defect

Search GEO for disease gene expression data for Alcohol-Related Birth Defect.

Pathways for genes affiliated with Alcohol-Related Birth Defect

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Sources:
50PathCards, 51PharmGKB, 60Thomson Reuters, 38NCBI BioSystems Database, 55Reactome, 30KEGG
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Pathways related to Alcohol-Related Birth Defect according to GeneCards/GeneDecks:

idSuper pathways (with members indented)ScoreTop Affiliating Genes
1
Show member pathways
9.3AKR1A1, ADH1B
2
Show member pathways
glycolysis38
gluconeogenesis38
Glycolysis and Gluconeogenesis38
9.3AKR1A1, ADH1B
3
Show member pathways
tryptophan degradation X (mammalian, via tryptamine)38
2-amino-3-carboxymuconate semialdehyde degradation to glutaryl-CoA38
tryptophan degradation38
glutaryl-CoA degradation38
serotonin degradation38
NAD de novo biosynthesis38
superpathway of melatonin degradation38
tryptophan degradation to 2-amino-3-carboxymuconate semialdehyde38
tryptophan utilization I38
melatonin degradation I38
9.3ADH1B, AKR1A1
49.1AKR1A1, CYP2E1
5
Show member pathways
9.0CYP2E1, ADH1B
6
Show member pathways
acetate conversion to acetyl-CoA38
oxidative ethanol degradation III38
ethanol degradation IV38
9.0ADH1B, CYP2E1
7
Show member pathways
9.0ADH1B, CYP2E1
8
Show member pathways
bupropion degradation38
methylglyoxal degradation III38
nicotine degradation III38
nicotine degradation IV38
9.0CYP2E1, ADH1B
9
Show member pathways
8.5AKR1A1, ADH1B, CYP2E1
10
Show member pathways
8.5AKR1A1, ADH1B, CYP2E1

Compounds for genes affiliated with Alcohol-Related Birth Defect

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Sources:
45Novoseek, 11DrugBank, 24HMDB, 51PharmGKB, 61Tocris Bioscience, 29IUPHAR
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Compounds related to Alcohol-Related Birth Defect according to GeneCards/GeneDecks:

(show all 37)
idCompoundScoreTop Affiliating Genes
1n-benzylformamide45 1110.7AKR1A1, ADH1B
2Propyl alcohol249.7ADH1B, AKR1A1
3Isopropyl alcohol249.7ADH1B, AKR1A1
4Isobutanol249.7ADH1B, AKR1A1
51-Pentanol249.7ADH1B, AKR1A1
61-Hexanol249.6ADH1B, AKR1A1
71-Butanol249.6ADH1B, AKR1A1
84-methylpyrazole459.5AKR1A1, CYP2E1
9isopropanol459.5AKR1A1, CYP2E1
10trichloroethylene459.5AKR1A1, CYP2E1
11pyrazole45 1110.5AKR1A1, CYP2E1
12benzyl alcohol45 1110.5CYP2E1, AKR1A1
13nash459.5AKR1A1, CYP2E1
14acetone459.5CYP2E1, AKR1A1
15disulfiram45 51 61 1112.4CYP2E1, AKR1A1
16cimetidine45 29 1111.4AKR1A1, CYP2E1
17polyacrylamide459.4ADH1B, AKR1A1
18epoxide459.4AKR1A1, CYP2E1
19menadione45 24 1111.4AKR1A1, CYP2E1
204-hydroxynonenal45 2410.4CYP2E1, AKR1A1
21nad29 2410.3AKR1A1, ADH1B
22phenobarbital45 29 51 1112.3AKR1A1, CYP2E1
23mspi459.3ADH1B, CYP2E1
24verapamil45 29 51 24 1113.3AKR1A1, CYP2E1
25formaldehyde45 2410.3CYP2E1, AKR1A1
26carbon459.2AKR1A1, CYP2E1
27nadh45 24 1111.2AKR1A1, ADH1B
28creatinine459.1AKR1A1, CYP2E1
29rsai458.9AKR1A1, ADH1B, CYP2E1
30acetaldehyde29 45 2410.9CYP2E1, ADH1B, AKR1A1
31NADP248.9CYP2E1, ADH1B, AKR1A1
32glycerol45 24 1110.9AKR1A1, ADH1B, CYP2E1
33vitamin a45 24 1110.9CYP2E1, ADH1B, AKR1A1
34ethanol45 51 24 1111.9CYP2E1, ADH1B, AKR1A1
35nadph45 249.9CYP2E1, ADH1B, AKR1A1
36dopamine45 29 24 1111.9AKR1A1, ADH1B, CYP2E1
37lactate458.8AKR1A1, CYP2E1

GO Terms for genes affiliated with Alcohol-Related Birth Defect

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Sources:
16Gene Ontology
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Biological processes related to Alcohol-Related Birth Defect according to GeneCards/GeneDecks:

idNameGO IDScoreTop Affiliating Genes
1xenobiotic metabolic processGO:0068059.0ADH1B, CYP2E1

Products for genes affiliated with Alcohol-Related Birth Defect

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  • Antibodies
  • Proteins
  • Lysates
  • Antibodies

Sources for Alcohol-Related Birth Defect

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4CDC
13ExPASy
14FMA
22GTR
23HGMD
24HMDB
25ICD10
26ICD10 via Orphanet
27ICD9CM
29IUPHAR
30KEGG
35MeSH
36MESH via Orphanet
37MGI
40NCIt
41NDF-RT
44NINDS
45Novoseek
47OMIM
48OMIM via Orphanet
52PubMed
53QIAGEN
59SNOMED-CT via Orphanet
62UMLS
63UMLS via Orphanet