ARBD
MCID: ALC001
MIFTS: 25

Alcohol-Related Birth Defect (ARBD) malady

Fetal diseases category

Summaries for Alcohol-Related Birth Defect

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Sources:
9Disease Ontology, 34MalaCards
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Disease Ontology:9 A fetal alcohol spectrum disorder that results in damage to organs, bones, or muscles due to prenatal alcohol exposure.

MalaCards: Alcohol-Related Birth Defect, also known as alcohol related birth defect, is related to fetal alcohol spectrum disorder and fetal alcohol syndrome. An important gene associated with Alcohol-Related Birth Defect is ADH1B (alcohol dehydrogenase 1B (class I), beta polypeptide), and among its related pathways are Cyclophosphamide Pathway, Pharmacodynamics and Glycolysis and gluconeogenesis short map . The compounds n-benzylformamide and Propyl alcohol have been mentioned in the context of this disorder. Affiliated tissues include bone.

Aliases & Classifications for Alcohol-Related Birth Defect

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Sources:
9Disease Ontology, 63UMLS
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Classifications:

Malacards categories (disease lists): (See all malacards categories)
Global: Fetal diseases


Aliases & Descriptions:

alcohol-related birth defect 9
alcohol related birth defect 63
arbd 9


External Ids:

Disease Ontology9 DOID:0050668

Related Diseases for Alcohol-Related Birth Defect

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Sources:
18GeneCards, 19GeneDecks
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Graphical network of the top 20 diseases related to Alcohol-Related Birth Defect:



Diseases related to alcohol-related birth defect

Symptoms for Alcohol-Related Birth Defect

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Drugs & Therapeutics for Alcohol-Related Birth Defect

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Sources:
6CenterWatch, 43NIH Clinical Center, 7ClinicalTrials
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Approved drugs:

Search CenterWatch for Alcohol-Related Birth Defect

Drug clinical trials:

Search ClinicalTrials for Alcohol-Related Birth Defect

Search NIH Clinical Center for Alcohol-Related Birth Defect

Search CenterWatch for Alcohol-Related Birth Defect

Genetic Tests for Alcohol-Related Birth Defect

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Anatomical Context for Alcohol-Related Birth Defect

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Sources:
34MalaCards
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MalaCards organs/tissues related to Alcohol-Related Birth Defect:

34
Bone

Animal Models for Alcohol-Related Birth Defect or affiliated genes

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Publications for Alcohol-Related Birth Defect

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Sources:
53PubMed
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Articles related to Alcohol-Related Birth Defect:

idTitleAuthorsYear
1
ADH2 and CYP2E1 genetic polymorphisms: risk factors for alcohol-related birth defects. (11259352)
2001
2
A multiple-level, comprehensive approach to the prevention of fetal alcohol syndrome (FAS) and other alcohol-related birth defects (ARBD). (8557409)
1995

Variations for Alcohol-Related Birth Defect

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Expression for genes affiliated with Alcohol-Related Birth Defect

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Sources:
2BioGPS, 16Gene Expression Omnibus DataSets
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Expression patterns in normal tissues for genes affiliated with Alcohol-Related Birth Defect

Search GEO for disease gene expression data for Alcohol-Related Birth Defect.

Pathways for genes affiliated with Alcohol-Related Birth Defect

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Sources:
51PathCards, 52PharmGKB, 61Thomson Reuters, 39NCBI BioSystems Database, 56Reactome, 31KEGG
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Pathways related to Alcohol-Related Birth Defect according to GeneCards/GeneDecks:

idSuper pathways (with members indented)ScoreTop Affiliating Genes
1
Show member pathways
9.3AKR1A1, ADH1B
2
Show member pathways
glycolysis39
gluconeogenesis39
Glycolysis and Gluconeogenesis39
9.3AKR1A1, ADH1B
3
Show member pathways
tryptophan degradation X (mammalian, via tryptamine)39
2-amino-3-carboxymuconate semialdehyde degradation to glutaryl-CoA39
tryptophan degradation39
glutaryl-CoA degradation39
serotonin degradation39
NAD de novo biosynthesis39
superpathway of melatonin degradation39
tryptophan degradation to 2-amino-3-carboxymuconate semialdehyde39
tryptophan utilization I39
melatonin degradation I39
9.3ADH1B, AKR1A1
49.1AKR1A1, CYP2E1
5
Show member pathways
9.0CYP2E1, ADH1B
6
Show member pathways
acetate conversion to acetyl-CoA39
oxidative ethanol degradation III39
ethanol degradation IV39
9.0ADH1B, CYP2E1
7
Show member pathways
9.0ADH1B, CYP2E1
8
Show member pathways
bupropion degradation39
methylglyoxal degradation III39
nicotine degradation III39
nicotine degradation IV39
9.0CYP2E1, ADH1B
9
Show member pathways
8.5AKR1A1, ADH1B, CYP2E1
10
Show member pathways
8.5AKR1A1, ADH1B, CYP2E1

Compounds for genes affiliated with Alcohol-Related Birth Defect

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Sources:
46Novoseek, 12DrugBank, 25HMDB, 52PharmGKB, 62Tocris Bioscience, 30IUPHAR
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Compounds related to Alcohol-Related Birth Defect according to GeneCards/GeneDecks:

(show all 37)
idCompoundScoreTop Affiliating Genes
1n-benzylformamide46 1210.7AKR1A1, ADH1B
2Propyl alcohol259.7ADH1B, AKR1A1
3Isopropyl alcohol259.7ADH1B, AKR1A1
4Isobutanol259.7ADH1B, AKR1A1
51-Pentanol259.7ADH1B, AKR1A1
61-Hexanol259.6ADH1B, AKR1A1
71-Butanol259.6ADH1B, AKR1A1
84-methylpyrazole469.5AKR1A1, CYP2E1
9isopropanol469.5AKR1A1, CYP2E1
10trichloroethylene469.5AKR1A1, CYP2E1
11pyrazole46 1210.5AKR1A1, CYP2E1
12benzyl alcohol46 1210.5CYP2E1, AKR1A1
13nash469.5AKR1A1, CYP2E1
14acetone469.5CYP2E1, AKR1A1
15disulfiram46 52 62 1212.4CYP2E1, AKR1A1
16cimetidine46 30 1211.4AKR1A1, CYP2E1
17polyacrylamide469.4ADH1B, AKR1A1
18epoxide469.4AKR1A1, CYP2E1
19menadione46 25 1211.4AKR1A1, CYP2E1
204-hydroxynonenal46 2510.4CYP2E1, AKR1A1
21nad30 2510.3AKR1A1, ADH1B
22phenobarbital46 30 52 1212.3AKR1A1, CYP2E1
23mspi469.3ADH1B, CYP2E1
24verapamil46 30 52 25 1213.3AKR1A1, CYP2E1
25formaldehyde46 2510.3CYP2E1, AKR1A1
26carbon469.2AKR1A1, CYP2E1
27nadh46 25 1211.2AKR1A1, ADH1B
28creatinine469.1AKR1A1, CYP2E1
29rsai468.9AKR1A1, ADH1B, CYP2E1
30acetaldehyde30 46 2510.9CYP2E1, ADH1B, AKR1A1
31NADP258.9CYP2E1, ADH1B, AKR1A1
32glycerol46 25 1210.9AKR1A1, ADH1B, CYP2E1
33vitamin a46 25 1210.9CYP2E1, ADH1B, AKR1A1
34ethanol46 52 25 1211.9CYP2E1, ADH1B, AKR1A1
35nadph46 259.9CYP2E1, ADH1B, AKR1A1
36dopamine46 30 25 1211.9AKR1A1, ADH1B, CYP2E1
37lactate468.8AKR1A1, CYP2E1

GO Terms for genes affiliated with Alcohol-Related Birth Defect

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Sources:
17Gene Ontology
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Biological processes related to Alcohol-Related Birth Defect according to GeneCards/GeneDecks:

idNameGO IDScoreTop Affiliating Genes
1xenobiotic metabolic processGO:0068059.0ADH1B, CYP2E1

Products for genes affiliated with Alcohol-Related Birth Defect

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  • Antibodies
  • Proteins
  • Lysates
  • Antibodies

Sources for Alcohol-Related Birth Defect

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4CDC
14ExPASy
15FMA
23GTR
24HGMD
25HMDB
26ICD10
27ICD10 via Orphanet
28ICD9CM
30IUPHAR
31KEGG
36MeSH
37MESH via Orphanet
38MGI
41NCIt
42NDF-RT
45NINDS
46Novoseek
48OMIM
49OMIM via Orphanet
53PubMed
54QIAGEN
60SNOMED-CT via Orphanet
63UMLS
64UMLS via Orphanet