MCID: ALC001
MIFTS: 21

Alcohol-Related Birth Defect malady

Aliases & Classifications for Alcohol-Related Birth Defect

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Aliases & Descriptions for Alcohol-Related Birth Defect:

Name: Alcohol-Related Birth Defect 8
Alcohol Related Birth Defect 61
 
Fetal Alcohol Syndrome 61
Arbd 8


External Ids:

Disease Ontology8 DOID:0050668

Summaries for Alcohol-Related Birth Defect

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Disease Ontology:8 A fetal alcohol spectrum disorder that results in damage to organs, bones, or muscles due to prenatal alcohol exposure.

MalaCards based summary: Alcohol-Related Birth Defect, also known as alcohol related birth defect, is related to fetal alcohol syndrome and fetal alcohol spectrum disorder. An important gene associated with Alcohol-Related Birth Defect is ADH1B (alcohol dehydrogenase 1B (class I), beta polypeptide), and among its related pathways are Cyclophosphamide Pathway, Pharmacodynamics and Glycolysis and gluconeogenesis short map . The compounds n-benzylformamide and Propyl alcohol have been mentioned in the context of this disorder. Affiliated tissues include bone.

Related Diseases for Alcohol-Related Birth Defect

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Graphical network of the top 20 diseases related to Alcohol-Related Birth Defect:



Diseases related to alcohol-related birth defect

Symptoms for Alcohol-Related Birth Defect

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Drugs & Therapeutics for Alcohol-Related Birth Defect

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Drug clinical trials:

Search ClinicalTrials for Alcohol-Related Birth Defect

Search NIH Clinical Center for Alcohol-Related Birth Defect

Genetic Tests for Alcohol-Related Birth Defect

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Anatomical Context for Alcohol-Related Birth Defect

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MalaCards organs/tissues related to Alcohol-Related Birth Defect:

31
Bone

Animal Models for Alcohol-Related Birth Defect or affiliated genes

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Publications for Alcohol-Related Birth Defect

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Articles related to Alcohol-Related Birth Defect:

idTitleAuthorsYear
1
ADH2 and CYP2E1 genetic polymorphisms: risk factors for alcohol-related birth defects. (11259352)
2001
2
A multiple-level, comprehensive approach to the prevention of fetal alcohol syndrome (FAS) and other alcohol-related birth defects (ARBD). (8557409)
1995

Variations for Alcohol-Related Birth Defect

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Expression for genes affiliated with Alcohol-Related Birth Defect

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Search GEO for disease gene expression data for Alcohol-Related Birth Defect.

Pathways for genes affiliated with Alcohol-Related Birth Defect

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Pathways related to Alcohol-Related Birth Defect according to GeneCards Suite gene sharing:

idSuper pathways (with members indented)ScoreTop Affiliating Genes
1
Show member pathways
9.3AKR1A1, ADH1B
2
Show member pathways
glycolysis36
gluconeogenesis36
Glycolysis and Gluconeogenesis36
9.3AKR1A1, ADH1B
3
Show member pathways
tryptophan degradation X (mammalian, via tryptamine)36
2-amino-3-carboxymuconate semialdehyde degradation to glutaryl-CoA36
tryptophan degradation36
glutaryl-CoA degradation36
serotonin degradation36
NAD de novo biosynthesis36
superpathway of melatonin degradation36
tryptophan degradation to 2-amino-3-carboxymuconate semialdehyde36
tryptophan utilization I36
melatonin degradation I36
9.3ADH1B, AKR1A1
49.1AKR1A1, CYP2E1
5
Show member pathways
9.0CYP2E1, ADH1B
6
Show member pathways
acetate conversion to acetyl-CoA36
oxidative ethanol degradation III36
ethanol degradation IV36
9.0ADH1B, CYP2E1
7
Show member pathways
9.0ADH1B, CYP2E1
8
Show member pathways
bupropion degradation36
methylglyoxal degradation III36
nicotine degradation III36
nicotine degradation IV36
9.0CYP2E1, ADH1B
9
Show member pathways
8.5AKR1A1, ADH1B, CYP2E1
10
Show member pathways
8.5AKR1A1, ADH1B, CYP2E1

Compounds for genes affiliated with Alcohol-Related Birth Defect

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Compounds related to Alcohol-Related Birth Defect according to GeneCards Suite gene sharing:

(show all 37)
idCompoundScoreTop Affiliating Genes
1n-benzylformamide44 1110.7ADH1B, AKR1A1
2Propyl alcohol249.7ADH1B, AKR1A1
3Isopropyl alcohol249.7ADH1B, AKR1A1
4Isobutanol249.7AKR1A1, ADH1B
51-Pentanol249.7ADH1B, AKR1A1
61-Hexanol249.6ADH1B, AKR1A1
71-Butanol249.6AKR1A1, ADH1B
84-methylpyrazole449.5CYP2E1, AKR1A1
9isopropanol449.5AKR1A1, CYP2E1
10trichloroethylene449.5AKR1A1, CYP2E1
11pyrazole44 1110.5AKR1A1, CYP2E1
12benzyl alcohol44 1110.5CYP2E1, AKR1A1
13nash449.5CYP2E1, AKR1A1
14acetone449.5CYP2E1, AKR1A1
15disulfiram44 50 60 1112.4AKR1A1, CYP2E1
16cimetidine44 28 1111.4CYP2E1, AKR1A1
17polyacrylamide449.4AKR1A1, ADH1B
18epoxide449.4AKR1A1, CYP2E1
19menadione44 24 1111.4CYP2E1, AKR1A1
204-hydroxynonenal44 2410.4CYP2E1, AKR1A1
21nad28 2410.3ADH1B, AKR1A1
22phenobarbital44 28 50 1112.3AKR1A1, CYP2E1
23mspi449.3CYP2E1, ADH1B
24verapamil44 28 50 24 1113.3AKR1A1, CYP2E1
25formaldehyde44 2410.3AKR1A1, CYP2E1
26carbon449.2AKR1A1, CYP2E1
27nadh44 24 1111.2AKR1A1, ADH1B
28creatinine449.1AKR1A1, CYP2E1
29rsai448.9AKR1A1, ADH1B, CYP2E1
30acetaldehyde28 44 2410.9AKR1A1, CYP2E1, ADH1B
31NADP248.9CYP2E1, ADH1B, AKR1A1
32glycerol44 24 1110.9AKR1A1, ADH1B, CYP2E1
33vitamin a44 24 1110.9ADH1B, CYP2E1, AKR1A1
34ethanol44 50 24 1111.9CYP2E1, ADH1B, AKR1A1
35nadph44 249.9AKR1A1, ADH1B, CYP2E1
36dopamine44 28 24 1111.9ADH1B, AKR1A1, CYP2E1
37lactate448.8CYP2E1, AKR1A1

GO Terms for genes affiliated with Alcohol-Related Birth Defect

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Biological processes related to Alcohol-Related Birth Defect according to GeneCards Suite gene sharing:

idNameGO IDScoreTop Affiliating Genes
1xenobiotic metabolic processGO:00068059.0ADH1B, CYP2E1

Sources for Alcohol-Related Birth Defect

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2CDC
12ExPASy
13FDA
14FMA
22GTR
23HGMD
24HMDB
25ICD10
26ICD10 via Orphanet
27ICD9CM
28IUPHAR
29KEGG
33MeSH
34MESH via Orphanet
35MGI
38NCI
39NCIt
40NDF-RT
43NINDS
44Novoseek
46OMIM
47OMIM via Orphanet
51PubMed
52QIAGEN
57SNOMED-CT via Orphanet
61UMLS
62UMLS via Orphanet