ARND
MCID: ALC002
MIFTS: 25

Alcohol-Related Neurodevelopmental Disorder (ARND) malady

Neuronal category

Summaries for Alcohol-Related Neurodevelopmental Disorder

Sources:
8Disease Ontology, 33MalaCards
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Disease Ontology:8 A fetal alcohol spectrum disorder that results in central nervous system dysfunction and behavioral and/or cognitive deficits due to prenatal alcohol exposure.

MalaCards: Alcohol-Related Neurodevelopmental Disorder, also known as alcohol related neurodevelopmental disorder, is related to fetal alcohol syndrome and n syndrome. An important gene associated with Alcohol-Related Neurodevelopmental Disorder is WDR45 (WD repeat domain 45), and among its related pathways is Retinol metabolism. The compound acetaldehyde have been mentioned in the context of this disorder. Related mouse phenotypes are vision/eye and craniofacial.

Aliases & Classifications for Alcohol-Related Neurodevelopmental Disorder

Sources:
8Disease Ontology, 61UMLS
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Classifications:

Malacards categories (disease lists): (See all malacards categories)
Anatomical: Neuronal


Aliases & Descriptions:

alcohol-related neurodevelopmental disorder 8
alcohol related neurodevelopmental disorder 61
static encephalopathy 8
arnd 8


External Ids:

Disease Ontology8 DOID:0050667

Related Diseases for Alcohol-Related Neurodevelopmental Disorder

Sources:
17GeneCards, 18GeneDecks
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Diseases related to Alcohol-Related Neurodevelopmental Disorder via text searches within MalaCards or GeneCards/GeneDecks gene sharing:

idRelated DiseaseScoreTop Affiliating Genes
1fetal alcohol syndrome10.4
2n syndrome10.4
3neurodegeneration with brain iron accululation 510.2
4alcohol abuse10.2
5substance abuse10.2
6creatine transporter deficiency10.1
7acetabular dysplasia10.1
8partial fetal alcohol syndrome10.0PFAS
9fetal alcohol spectrum disorder10.0PFAS

Graphical network of diseases related to Alcohol-Related Neurodevelopmental Disorder:



Diseases related to alcohol-related neurodevelopmental disorder

Clinical Features for Alcohol-Related Neurodevelopmental Disorder

Drugs & Therapeutics for Alcohol-Related Neurodevelopmental Disorder

Sources:
5CenterWatch, 42NIH Clinical Center, 6ClinicalTrials
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Approved drugs:

Search CenterWatch for Alcohol-Related Neurodevelopmental Disorder

Drug clinical trials:

Search ClinicalTrials for Alcohol-Related Neurodevelopmental Disorder

Search NIH Clinical Center for Alcohol-Related Neurodevelopmental Disorder

Search CenterWatch for Alcohol-Related Neurodevelopmental Disorder

Genetic Tests for Alcohol-Related Neurodevelopmental Disorder

Anatomical Context for Alcohol-Related Neurodevelopmental Disorder

Animal Models for Alcohol-Related Neurodevelopmental Disorder or affiliated genes

Sources:
37MGI, 28inGenious Targeting Laboratory
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MGI Mouse Phenotypes related to Alcohol-Related Neurodevelopmental Disorder:

37
idDescriptionMGI Source AccessionScoreTop Affiliating Genes
1MP:00053918.8ZIC5, FA2H, PFAS, OTX2, ALDH1A2
2MP:00053828.7ALDH1A2, OTX2, PFAS, NKD2, ZIC5
3MP:00053908.7ALDH1A2, OTX2, PFAS, NKD2, ZIC5
4MP:00053787.4ZIC5, DIO3, DMBX1, NKD2, OTX2, EN2

Publications for Alcohol-Related Neurodevelopmental Disorder

Sources:
51PubMed
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Articles related to Alcohol-Related Neurodevelopmental Disorder:

idTitleAuthorsYear
1
The Toronto experience in diagnosing alcohol-related neurodevelopmental disorder: a unique profile of deficits and assets. (12584580)
2002
2
American Academy of Pediatrics. Committee on Substance Abuse and Committee on Children With Disabilities. Fetal alcohol syndrome and alcohol-related neurodevelopmental disorders. (10920168)
2000
3
Incidence of fetal alcohol syndrome and prevalence of alcohol-related neurodevelopmental disorder. (9451756)
1997
4
What research with animals is telling us about alcohol-related neurodevelopmental disorder. (8981579)
1996

Genetic Variations for Alcohol-Related Neurodevelopmental Disorder

Expression for genes affiliated with Alcohol-Related Neurodevelopmental Disorder

Sources:
1BioGPS, 15Gene Expression Omnibus DataSets
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Expression patterns in normal tissues for genes affiliated with Alcohol-Related Neurodevelopmental Disorder

Search GEO for disease gene expression data for Alcohol-Related Neurodevelopmental Disorder.

Pathways for genes affiliated with Alcohol-Related Neurodevelopmental Disorder

Sources:
12EMD Millipore
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Pathways related to Alcohol-Related Neurodevelopmental Disorder according to GeneCards/GeneDecks:

idSuper pathways (with members indented)ScoreTop Affiliating Genes
1
Retinol metabolism
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9.6ADHFE1, ALDH1A2

Compounds for genes affiliated with Alcohol-Related Neurodevelopmental Disorder

Sources:
45Novoseek, 29IUPHAR, 24HMDB
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Compounds related to Alcohol-Related Neurodevelopmental Disorder according to GeneCards/GeneDecks:

idCompoundScoreTop Affiliating Genes
1acetaldehyde45 29 2411.7ADH6, ALDH1A2

GO Terms for genes affiliated with Alcohol-Related Neurodevelopmental Disorder

Sources:
16Gene Ontology
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Biological processes related to Alcohol-Related Neurodevelopmental Disorder according to GeneCards/GeneDecks:

idNameGO IDScoreTop Affiliating Genes
1hindbrain developmentGO:0309029.9ALDH1A2, EN2
2forebrain developmentGO:0309009.8OTX2, ZIC5
3midbrain developmentGO:0309019.6EN2, OTX2
4autophagic vacuole assemblyGO:0000459.3WDR45, WIPI1

Molecular functions related to Alcohol-Related Neurodevelopmental Disorder according to GeneCards/GeneDecks:

idNameGO IDScoreTop Affiliating Genes
1phosphatidylinositol-3-phosphate bindingGO:0322669.4WDR45, WIPI1
2phosphatidylinositol-3,5-bisphosphate bindingGO:0800259.1WDR45, WIPI1

Products for genes affiliated with Alcohol-Related Neurodevelopmental Disorder

  • Antibodies
  • Proteins
  • Lysates
  • Antibodies

Sources for Alcohol-Related Neurodevelopmental Disorder

3CDC
13ExPASy
14FMA
22GTR
23HGMD
24HMDB
25ICD10
26ICD10 via Orphanet
27ICD9CM
29IUPHAR
30KEGG
35MeSH
36MESH via Orphanet
37MGI
40NCIt
41NDF-RT
44NINDS
45Novoseek
47OMIM
48OMIM via Orphanet
51PubMed
52QIAGEN
58SNOMED-CT via Orphanet
61UMLS
62UMLS via Orphanet