ARND
MCID: ALC002
MIFTS: 22

Alcohol-Related Neurodevelopmental Disorder (ARND) malady

Categories: Mental diseases, Neuronal diseases

Aliases & Classifications for Alcohol-Related Neurodevelopmental Disorder

Aliases & Descriptions for Alcohol-Related Neurodevelopmental Disorder:

Name: Alcohol-Related Neurodevelopmental Disorder 12 14
Static Encephalopathy 12 69
Alcohol Related Neurodevelopmental Disorder 69
Arnd 12

Classifications:



External Ids:

Disease Ontology 12 DOID:0050667

Summaries for Alcohol-Related Neurodevelopmental Disorder

Disease Ontology : 12 A fetal alcohol spectrum disorder that results in central nervous system dysfunction and behavioral and/or cognitive deficits due to prenatal alcohol exposure.

MalaCards based summary : Alcohol-Related Neurodevelopmental Disorder, also known as static encephalopathy, is related to neurodegeneration with brain iron accululation 5 and fetal alcohol spectrum disorder. An important gene associated with Alcohol-Related Neurodevelopmental Disorder is PFAS (Phosphoribosylformylglycinamidine Synthase). The drugs Dopamine and Methylphenidate have been mentioned in the context of this disorder.

Related Diseases for Alcohol-Related Neurodevelopmental Disorder

Diseases related to Alcohol-Related Neurodevelopmental Disorder via text searches within MalaCards or GeneCards Suite gene sharing:

(show all 12)
id Related Disease Score Top Affiliating Genes
1 neurodegeneration with brain iron accululation 5 11.8
2 fetal alcohol spectrum disorder 11.7
3 fetal alcohol syndrome 11.7
4 encephalopathy 10.0
5 chondrodysplasia punctata, x-linked dominant 9.9 C19orf12 WDR45
6 hereditary spastic paraplegia 51 9.9 C19orf12 WDR45
7 hirschsprung disease 7 9.9 C19orf12 WDR45
8 neonatal period electroclinical syndrome 9.8 PFAS WDR45
9 substance abuse 9.8
10 conjunctivitis 9.8
11 septooptic dysplasia 9.7 BOLA3 GCSH GLRX5
12 female breast cancer 9.1 BOLA3 C19orf12 GCSH GLRX5 PFAS WDR45

Graphical network of the top 20 diseases related to Alcohol-Related Neurodevelopmental Disorder:



Diseases related to Alcohol-Related Neurodevelopmental Disorder

Symptoms & Phenotypes for Alcohol-Related Neurodevelopmental Disorder

Drugs & Therapeutics for Alcohol-Related Neurodevelopmental Disorder

Drugs for Alcohol-Related Neurodevelopmental Disorder (from DrugBank, HMDB, Dgidb, PharmGKB, IUPHAR, NovoSeek, BitterDB):

(show all 30)
id Name Status Phase Clinical Trials Cas Number PubChem Id
1
Dopamine Approved Phase 4 51-61-6, 62-31-7 681
2
Methylphenidate Approved, Investigational Phase 4 113-45-1 4158
3 Neurotransmitter Agents Phase 4,Phase 3,Phase 1
4 Neurotransmitter Uptake Inhibitors Phase 4,Phase 3,Phase 1
5 Central Nervous System Stimulants Phase 4
6 Dopamine Agents Phase 4
7 Dopamine Uptake Inhibitors Phase 4
8
Ethanol Approved Phase 3,Phase 2,Phase 1 64-17-5 702
9 Adrenergic Agents Phase 3,Phase 1
10 Atomoxetine Hydrochloride Phase 3,Phase 1
11 Anti-Infective Agents Phase 2, Phase 3,Phase 1
12 Anti-Infective Agents, Local Phase 2, Phase 3,Phase 1
13 Central Nervous System Depressants Phase 2, Phase 3,Phase 1
14 Antioxidants Phase 2, Phase 3
15
Epigallocatechin gallate Phase 2, Phase 3 989-51-5 65064
16 Neuroprotective Agents Phase 2, Phase 3
17 Protective Agents Phase 2, Phase 3
18
Epigallocatechin Experimental, Nutraceutical Phase 2, Phase 3 970-74-1 72277
19
Glycerol Approved, Experimental Phase 2 56-81-5 753
20
Choline Approved, Nutraceutical Phase 2,Phase 1 62-49-7 305
21 Antimetabolites Phase 2,Phase 1
22 Gastrointestinal Agents Phase 2,Phase 1
23 Hypolipidemic Agents Phase 2,Phase 1
24 Lipid Regulating Agents Phase 2,Phase 1
25 Nootropic Agents Phase 2,Phase 1
26
Naltrexone Approved, Investigational, Vet_approved 16590-41-3 5360515
27 Detox adjuvant
28 Narcotic Antagonists
29 Narcotics
30 Peripheral Nervous System Agents

Interventional clinical trials:

(show all 21)
id Name Status NCT ID Phase
1 Treatment of Patients With Alcoholism and Attention Deficit Disorder Completed NCT00261872 Phase 4
2 Open-Label Study of the Long Term Tolerability and Safety of Atomoxetine in Children With FASD and ADD/ADHD Unknown status NCT00418262 Phase 3
3 Personality-targeted Interventions for Adolescent Alcohol Misuse Completed NCT00344474 Phase 2, Phase 3
4 Adventure: Teacher Delivered Personality-targeted Interventions for Substance Misuse Completed NCT00776685 Phase 2, Phase 3
5 Epigallocatechin Gallate (EGCG) to Improve Cognitive Performance in Foetal Alcohol Syndrome (FAS) Children Recruiting NCT02558933 Phase 2, Phase 3
6 Neurocognitive Habilitation for Children With Fetal Alcohol Syndrome (FAS)/Alcohol-Related Neurodevelopmental Disorder (ARND) Completed NCT00164346 Phase 1, Phase 2
7 Choline Supplementation in Children With Fetal Alcohol Spectrum Disorders Completed NCT01911299 Phase 2
8 Postnatal Choline Supplementation in Children With Prenatal Alcohol Exposure Completed NCT01149538 Phase 1, Phase 2
9 Choline Supplementation as a Neurodevelopmental Intervention in Fetal Alcohol Spectrum Disorders Recruiting NCT02735473 Phase 2
10 Assess the Effectiveness of Atomoxetine in Children With Fetal Alcohol Syndrome and ADD/ADHD Completed NCT00417794 Phase 1
11 Prevention and Reduction of Alcohol and Drug Problems in a Clinical Psychiatric Youth Population Unknown status NCT01595568
12 Development of Education Materials for Prevention of FAS in Russia Completed NCT01971398
13 Expansion to Interdisciplinary HIV Prevention in Women Completed NCT01994603
14 Preventing FAS/ARND in Russian Children Completed NCT01961050
15 Reliability and Validity of the MINI International Neuropsychiatric Interview for Children and Adolescents (MINI-KID) Completed NCT00579267
16 Parenting Training for Children With FASD Recruiting NCT02210455
17 Helping College Students With ADHD Lead Healthier Lifestyles Recruiting NCT02829970
18 Rare Disease Patient Registry & Natural History Study - Coordination of Rare Diseases at Sanford Recruiting NCT01793168
19 ADHD: Gaps Between Patients With Alcohol-dependence and Impact on Relapse Recruiting NCT02364817
20 Does Delaying Adolescent Substance Use Lead to Improved Cognitive Function and Reduce Risk for Addiction? Active, not recruiting NCT01655615
21 Control of Cognition Active, not recruiting NCT01993108

Search NIH Clinical Center for Alcohol-Related Neurodevelopmental Disorder

Genetic Tests for Alcohol-Related Neurodevelopmental Disorder

Anatomical Context for Alcohol-Related Neurodevelopmental Disorder

Publications for Alcohol-Related Neurodevelopmental Disorder

Articles related to Alcohol-Related Neurodevelopmental Disorder:

id Title Authors Year
1
Visual search for feature conjunctions: an fMRI study comparing alcohol-related neurodevelopmental disorder (ARND) to ADHD. ( 25750685 )
2015
2
Cortical morphology in children with alcohol-related neurodevelopmental disorder. ( 24653953 )
2014
3
Hippocampal abnormalities in youth with alcohol-related neurodevelopmental disorder. ( 24512673 )
2014
4
The Toronto experience in diagnosing alcohol-related neurodevelopmental disorder: a unique profile of deficits and assets. ( 12584580 )
2002
5
American Academy of Pediatrics. Committee on Substance Abuse and Committee on Children With Disabilities. Fetal alcohol syndrome and alcohol-related neurodevelopmental disorders. ( 10920168 )
2000
6
Incidence of fetal alcohol syndrome and prevalence of alcohol-related neurodevelopmental disorder. ( 9451756 )
1997
7
What research with animals is telling us about alcohol-related neurodevelopmental disorder. ( 8981579 )
1996

Variations for Alcohol-Related Neurodevelopmental Disorder

Expression for Alcohol-Related Neurodevelopmental Disorder

Search GEO for disease gene expression data for Alcohol-Related Neurodevelopmental Disorder.

Pathways for Alcohol-Related Neurodevelopmental Disorder

GO Terms for Alcohol-Related Neurodevelopmental Disorder

Cellular components related to Alcohol-Related Neurodevelopmental Disorder according to GeneCards Suite gene sharing:

id Name GO ID Score Top Affiliating Genes
1 mitochondrion GO:0005739 8.92 BOLA3 C19orf12 GCSH GLRX5

Biological processes related to Alcohol-Related Neurodevelopmental Disorder according to GeneCards Suite gene sharing:

id Name GO ID Score Top Affiliating Genes
1 autophagy GO:0006914 8.96 C19orf12 WDR45
2 protein lipoylation GO:0009249 8.62 GCSH GLRX5

Sources for Alcohol-Related Neurodevelopmental Disorder

3 CDC
7 CNVD
9 Cosmic
10 dbSNP
11 DGIdb
16 ExPASy
18 FMA
28 GO
29 GTR
30 HGMD
31 HMDB
32 HPO
33 ICD10
34 ICD10 via Orphanet
35 ICD9CM
36 IUPHAR
37 KEGG
38 LifeMap
40 MedGen
42 MeSH
43 MESH via Orphanet
44 MGI
46 NCI
47 NCIt
48 NDF-RT
51 NINDS
52 Novoseek
54 OMIM
55 OMIM via Orphanet
59 PubMed
60 QIAGEN
65 SNOMED-CT via Orphanet
67 TGDB
68 Tocris
69 UMLS
70 UMLS via Orphanet
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