MCID: ALC016
MIFTS: 17

Alcohol Sensitivity, Acute

Categories: Genetic diseases, Rare diseases, Mental diseases

Aliases & Classifications for Alcohol Sensitivity, Acute

MalaCards integrated aliases for Alcohol Sensitivity, Acute:

Name: Alcohol Sensitivity, Acute 53 13
Acute Alcohol Sensitivity 49 36 28
Hangover, Susceptibility to 53 49
Alcohol Intolerance 49
Hangover 53

Characteristics:

OMIM:

53
Inheritance:
autosomal dominant

Miscellaneous:
aldh2*1 and aldh2*2 are inactive alleles found more commonly in asians


HPO:

31
alcohol sensitivity, acute:
Inheritance autosomal dominant inheritance


Classifications:



External Ids:

OMIM 53 610251
MedGen 39 C2674838
KEGG 36 H01071
SNOMED-CT via HPO 65 263681008

Summaries for Alcohol Sensitivity, Acute

NIH Rare Diseases : 49 Alcohol intolerance is characterized by immediate unpleasant reactions after drinking alcohol. The most common signs and symptoms of alcohol intolerance are stuffy nose and skin flushing. Alcohol intolerance is caused by a genetic condition in which the body is unable to break down alcohol efficiently, usually found in Asians. These individuals accumulate acetaldehyde, the primary metabolite of ethanol, because of a genetic polymorphism of aldehyde dehydrogenase (ALDH) that metabolizes acetaldehyde to nontoxic acetate. The only way to prevent alcohol intolerance reactions is to avoid alcohol. Alcohol intolerance isn't an allergy. However, in some cases, what seems to be alcohol intolerance may be a reaction to something in an alcoholic beverage, such as chemicals, grains or preservatives. Combining alcohol with certain medications also can cause reactions. In rare instances, an unpleasant reaction to alcohol can be a sign of a serious underlying health problem that requires diagnosis and treatment. Last updated: 6/26/2015

MalaCards based summary : Alcohol Sensitivity, Acute, is also known as acute alcohol sensitivity, and has symptoms including facial flushing after alcohol intake and delayed oxidation of acetaldehyde. An important gene associated with Alcohol Sensitivity, Acute is ALDH2 (Aldehyde Dehydrogenase 2 Family (Mitochondrial)), and among its related pathways/superpathways is Glycolysis / Gluconeogenesis. Affiliated tissues include skin.

Description from OMIM: 610251

Related Diseases for Alcohol Sensitivity, Acute

Diseases in the Alcohol Abuse family:

Alcohol Sensitivity, Acute Alcohol Use Disorder

Symptoms & Phenotypes for Alcohol Sensitivity, Acute

Symptoms via clinical synopsis from OMIM:

53
HeadAndNeckFace:
facial flushing after alcohol intake

MetabolicFeatures:
excessive acetaldehyde accumulation after alcohol consumption

NeurologicBehavioralPsychiatricManifestations:
increased intoxicating symptoms after alcohol consumption
aldh2*2 carriers suffer more severe hangovers

LaboratoryAbnormalities:
enzymatically inactive aldh2
delayed oxidation of acetaldehyde


Clinical features from OMIM:

610251

Human phenotypes related to Alcohol Sensitivity, Acute:

31
# Description HPO Frequency HPO Source Accession
1 facial flushing after alcohol intake 31 HP:0001033
2 delayed oxidation of acetaldehyde 31 HP:0003533

Drugs & Therapeutics for Alcohol Sensitivity, Acute

Search Clinical Trials , NIH Clinical Center for Alcohol Sensitivity, Acute

Genetic Tests for Alcohol Sensitivity, Acute

Genetic tests related to Alcohol Sensitivity, Acute:

# Genetic test Affiliating Genes
1 Acute Alcohol Sensitivity 28 ALDH2

Anatomical Context for Alcohol Sensitivity, Acute

MalaCards organs/tissues related to Alcohol Sensitivity, Acute:

38
Skin

Publications for Alcohol Sensitivity, Acute

Articles related to Alcohol Sensitivity, Acute:

# Title Authors Year
1
Prostaglandins in alcohol intolerance and hangover. ( 6352219 )
1983

Variations for Alcohol Sensitivity, Acute

ClinVar genetic disease variations for Alcohol Sensitivity, Acute:

6
# Gene Variation Type Significance SNP ID Assembly Location
1 ALDH2 NM_000690.3(ALDH2): c.1510G> A (p.Glu504Lys) single nucleotide variant Pathogenic,protective,risk factor rs671 GRCh37 Chromosome 12, 112241766: 112241766

Expression for Alcohol Sensitivity, Acute

Search GEO for disease gene expression data for Alcohol Sensitivity, Acute.

Pathways for Alcohol Sensitivity, Acute

Pathways related to Alcohol Sensitivity, Acute according to KEGG:

36
# Name Kegg Source Accession
1 Glycolysis / Gluconeogenesis hsa00010

GO Terms for Alcohol Sensitivity, Acute

Sources for Alcohol Sensitivity, Acute

3 CDC
7 CNVD
9 Cosmic
10 dbSNP
11 DGIdb
16 ExPASy
18 FMA
27 GO
28 GTR
29 HGMD
30 HMDB
31 HPO
32 ICD10
33 ICD10 via Orphanet
34 ICD9CM
35 IUPHAR
36 KEGG
37 LifeMap
39 MedGen
41 MeSH
42 MESH via Orphanet
43 MGI
45 NCI
46 NCIt
47 NDF-RT
50 NINDS
51 Novoseek
53 OMIM
54 OMIM via Orphanet
58 PubMed
60 QIAGEN
65 SNOMED-CT via HPO
66 SNOMED-CT via Orphanet
67 TGDB
68 Tocris
69 UMLS
70 UMLS via Orphanet
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