MCID: ALC016
MIFTS: 21

Alcohol Sensitivity, Acute malady

Categories: Genetic diseases, Rare diseases, Mental diseases

Aliases & Classifications for Alcohol Sensitivity, Acute

Aliases & Descriptions for Alcohol Sensitivity, Acute:

Name: Alcohol Sensitivity, Acute 54 13
Acute Alcohol Sensitivity 50 29
Hangover, Susceptibility to 50
Alcohol Intolerance 50
Hangover 54

Classifications:



External Ids:

OMIM 54 610251

Summaries for Alcohol Sensitivity, Acute

NIH Rare Diseases : 50 alcohol intolerance is characterized by immediate unpleasant reactions after drinking alcohol. the most common signs and symptoms of alcohol intolerance are stuffy nose and skin flushing. alcohol intolerance is caused by a genetic condition in which the body is unable to break down alcohol efficiently, usually found in asians. these individuals accumulate acetaldehyde, the primary metabolite of ethanol, because of a genetic polymorphism of aldehyde dehydrogenase (aldh) that metabolizes acetaldehyde to nontoxic acetate. the only way to prevent alcohol intolerance reactions is to avoid alcohol. alcohol intolerance isn't an allergy. however, in some cases, what seems to be alcohol intolerance may be a reaction to something in an alcoholic beverage, such as chemicals, grains or preservatives. combining alcohol with certain medications also can cause reactions. in rare instances, an unpleasant reaction to alcohol can be a sign of a serious underlying health problem that requires diagnosis and treatment. last updated: 6/26/2015

MalaCards based summary : Alcohol Sensitivity, Acute, is also known as acute alcohol sensitivity, and has symptoms including facial flushing after alcohol intake and delayed oxidation of acetaldehyde. An important gene associated with Alcohol Sensitivity, Acute is ALDH2 (Aldehyde Dehydrogenase 2 Family (Mitochondrial)). The drugs Ethanol and Cyclosporine have been mentioned in the context of this disorder. Affiliated tissues include skin.

Description from OMIM: 610251

Related Diseases for Alcohol Sensitivity, Acute

Diseases in the Alcohol Abuse family:

Alcohol Sensitivity, Acute

Symptoms & Phenotypes for Alcohol Sensitivity, Acute

Clinical features from OMIM:

610251

Human phenotypes related to Alcohol Sensitivity, Acute:

32
id Description HPO Frequency HPO Source Accession
1 facial flushing after alcohol intake 32 HP:0001033
2 delayed oxidation of acetaldehyde 32 HP:0003533

Drugs & Therapeutics for Alcohol Sensitivity, Acute

Drugs for Alcohol Sensitivity, Acute (from DrugBank, HMDB, Dgidb, PharmGKB, IUPHAR, NovoSeek, BitterDB):

(show all 49)
id Name Status Phase Clinical Trials Cas Number PubChem Id
1
Ethanol Approved Phase 3,Phase 1 64-17-5 702
2
Cyclosporine Approved, Investigational, Vet_approved Phase 3 79217-60-0, 59865-13-3 5284373 6435893
3
Prednisolone Approved, Vet_approved Phase 3 50-24-8 5755
4
Miconazole Approved, Investigational, Vet_approved Phase 3 22916-47-8 4189
5
Methylprednisolone Approved, Vet_approved Phase 3 83-43-2 6741
6
Acetylcysteine Approved, Investigational Phase 3 616-91-1 12035
7 Prednisolone acetate Phase 3
8 N-monoacetylcystine Phase 3
9 Dermatologic Agents Phase 3
10 Pharmaceutical Solutions Phase 3
11 Prednisolone hemisuccinate Phase 3
12 Prednisolone phosphate Phase 3
13 Expectorants Phase 3
14 Anti-Infective Agents Phase 3,Phase 2,Phase 1
15 Immunosuppressive Agents Phase 3,Phase 2
16 Protective Agents Phase 3
17 Antidotes Phase 3
18 Antifungal Agents Phase 3
19 Liver Extracts Phase 3
20 Respiratory System Agents Phase 3
21 Methylprednisolone acetate Phase 3
22 Methylprednisolone Hemisuccinate Phase 3
23 Antirheumatic Agents Phase 3
24 Calcineurin Inhibitors Phase 3
25 Antiviral Agents Phase 3
26 Antioxidants Phase 3
27 cysteine Nutraceutical Phase 3
28
Docetaxel Approved May 1996, Investigational Phase 2 114977-28-5 148124 9877265
29 Angiogenesis Inhibitors Phase 2
30 Angiogenesis Modulating Agents Phase 2
31 Anti-Bacterial Agents Phase 2
32 Antimitotic Agents Phase 2
33
Uric Acid Experimental, Investigational Phase 1 69-93-2 1175
34 Anti-Infective Agents, Local Phase 1
35 Central Nervous System Depressants Phase 1
36 Adrenergic Agents Phase 1
37 Neurotransmitter Agents Phase 1
38 Neurotransmitter Uptake Inhibitors Phase 1
39 Atomoxetine Hydrochloride Phase 1
40 Tea Nutraceutical Phase 1
41
Formaldehyde Approved, Vet_approved 50-00-0 712
42
Prazosin Approved 19216-56-9 4893
43
Menthol Approved 2216-51-5 16666
44
Metformin Approved 657-24-9 14219 4091
45 Ether
46 Disinfectants
47 Clofibric Acid 882-09-7
48 insulin
49 Insulin, Globin Zinc

Interventional clinical trials:

(show all 17)
id Name Status NCT ID Phase
1 Treatment of Severe Alcoholic Hepatitis With Corticoids Plus N Acetyl Cysteine Versus Corticoids Alone Completed NCT00863785 Phase 3
2 CYCLosporinE A in Reperfused Acute Myocardial Infarction Completed NCT01650662 Phase 3
3 Engaging Seronegative Youth to Optimize HIV Prevention Continuum Recruiting NCT03134833 Phase 3
4 Pregnenolone and Marijuana Dependence Completed NCT02439814 Phase 2
5 Thalidomide to Treat Oral Lesions in HIV-Infected Patients Completed NCT00001524 Phase 2
6 Efficacy and Safety Study of LE-DT to Treat Metastatic Castrate Resistant Prostate Cancer Terminated NCT01188408 Phase 2
7 Postprandial Effect of Chinese Tea Flavor Liquor on Selected CVD Risk Factors Completed NCT01264666 Phase 1
8 A Gene by Medication Interaction to the Acute Effects of Alcohol Terminated NCT01343628 Phase 1
9 A Dose Response Effect of Atomoxetine to the Acute Effects of Alcohol Terminated NCT01408589 Phase 1
10 Influence of Age and Sex on Alcohol Metabolism and Acute Responses Completed NCT00070577
11 Alcohol Exposure and Airway Hyperresponsiveness Completed NCT00990275
12 Diagnosis of Neglected Tropical Diseases Among Patients With Persistent Digestive Disorders Completed NCT02105714
13 Prognostic Indicators as Provided by the EPIC ClearView Completed NCT01476995
14 Alcohol Effects on Driving-related Skills of Young Drivers Recruiting NCT02710578
15 Multimodal Neuroimaging of Stress and Reward Cues to Assess Alcoholism Risk and Relapse Recruiting NCT02616094
16 PROstaTe Cancer - Exercise-STudy (PRO-TEST) Recruiting NCT02954783
17 PGC-1 & Muscle Mitochondrial Dysfunction in Diabetes Terminated NCT02282423

Search NIH Clinical Center for Alcohol Sensitivity, Acute

Genetic Tests for Alcohol Sensitivity, Acute

Genetic tests related to Alcohol Sensitivity, Acute:

id Genetic test Affiliating Genes
1 Acute Alcohol Sensitivity 29

Anatomical Context for Alcohol Sensitivity, Acute

MalaCards organs/tissues related to Alcohol Sensitivity, Acute:

39
Skin

Publications for Alcohol Sensitivity, Acute

Variations for Alcohol Sensitivity, Acute

ClinVar genetic disease variations for Alcohol Sensitivity, Acute:

6
id Gene Variation Type Significance SNP ID Assembly Location
1 ALDH2 NM_000690.3(ALDH2): c.1510G> A (p.Glu504Lys) single nucleotide variant Pathogenic,protective,risk factor rs671 GRCh37 Chromosome 12, 112241766: 112241766

Expression for Alcohol Sensitivity, Acute

Search GEO for disease gene expression data for Alcohol Sensitivity, Acute.

Pathways for Alcohol Sensitivity, Acute

GO Terms for Alcohol Sensitivity, Acute

Sources for Alcohol Sensitivity, Acute

3 CDC
7 CNVD
9 Cosmic
10 dbSNP
11 DGIdb
16 ExPASy
18 FMA
28 GO
29 GTR
30 HGMD
31 HMDB
32 HPO
33 ICD10
34 ICD10 via Orphanet
35 ICD9CM
36 IUPHAR
37 KEGG
38 LifeMap
40 MedGen
42 MeSH
43 MESH via Orphanet
44 MGI
46 NCI
47 NCIt
48 NDF-RT
51 NINDS
52 Novoseek
54 OMIM
55 OMIM via Orphanet
59 PubMed
60 QIAGEN
65 SNOMED-CT via Orphanet
67 TGDB
68 Tocris
69 UMLS
70 UMLS via Orphanet
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