MCID: ALC016
MIFTS: 23

Alcohol Sensitivity, Acute

Categories: Genetic diseases, Rare diseases, Mental diseases

Aliases & Classifications for Alcohol Sensitivity, Acute

MalaCards integrated aliases for Alcohol Sensitivity, Acute:

Name: Alcohol Sensitivity, Acute 54 13
Acute Alcohol Sensitivity 50 29
Hangover, Susceptibility to 50
Alcohol Intolerance 50
Hangover 54

Characteristics:

OMIM:

54
Miscellaneous:
aldh2*1 and aldh2*2 are inactive alleles found more commonly in asians

Inheritance:
autosomal dominant


Classifications:



External Ids:

OMIM 54 610251

Summaries for Alcohol Sensitivity, Acute

NIH Rare Diseases : 50 alcohol intolerance is characterized by immediate unpleasant reactions after drinking alcohol. the most common signs and symptoms of alcohol intolerance are stuffy nose and skin flushing. alcohol intolerance is caused by a genetic condition in which the body is unable to break down alcohol efficiently, usually found in asians. these individuals accumulate acetaldehyde, the primary metabolite of ethanol, because of a genetic polymorphism of aldehyde dehydrogenase (aldh) that metabolizes acetaldehyde to nontoxic acetate. the only way to prevent alcohol intolerance reactions is to avoid alcohol. alcohol intolerance isn't an allergy. however, in some cases, what seems to be alcohol intolerance may be a reaction to something in an alcoholic beverage, such as chemicals, grains or preservatives. combining alcohol with certain medications also can cause reactions. in rare instances, an unpleasant reaction to alcohol can be a sign of a serious underlying health problem that requires diagnosis and treatment. last updated: 6/26/2015

MalaCards based summary : Alcohol Sensitivity, Acute, is also known as acute alcohol sensitivity, and has symptoms including facial flushing after alcohol intake and delayed oxidation of acetaldehyde. An important gene associated with Alcohol Sensitivity, Acute is ALDH2 (Aldehyde Dehydrogenase 2 Family (Mitochondrial)). The drugs Acetylcysteine and Ethanol have been mentioned in the context of this disorder. Affiliated tissues include skin and liver.

Description from OMIM: 610251

Related Diseases for Alcohol Sensitivity, Acute

Diseases in the Alcohol Abuse family:

Alcohol Sensitivity, Acute

Symptoms & Phenotypes for Alcohol Sensitivity, Acute

Symptoms via clinical synopsis from OMIM:

54

Laboratory- Abnormalities:
delayed oxidation of acetaldehyde
enzymatically inactive aldh2

Neurologic- Behavioral Psychiatric Manifestations:
aldh2*2 carriers suffer more severe hangovers
increased intoxicating symptoms after alcohol consumption

Metabolic Features:
excessive acetaldehyde accumulation after alcohol consumption

Head And Neck- Face:
facial flushing after alcohol intake


Clinical features from OMIM:

610251

Human phenotypes related to Alcohol Sensitivity, Acute:

32
id Description HPO Frequency HPO Source Accession
1 facial flushing after alcohol intake 32 HP:0001033
2 delayed oxidation of acetaldehyde 32 HP:0003533

Drugs & Therapeutics for Alcohol Sensitivity, Acute

Drugs for Alcohol Sensitivity, Acute (from DrugBank, HMDB, Dgidb, PharmGKB, IUPHAR, NovoSeek, BitterDB):

(show all 36)
id Name Status Phase Clinical Trials Cas Number PubChem Id
1
Acetylcysteine Approved, Investigational Phase 3 616-91-1 12035
2
Ethanol Approved Phase 3,Phase 1 64-17-5 702
3
Methylprednisolone Approved, Vet_approved Phase 3 83-43-2 6741
4
Prednisolone Approved, Vet_approved Phase 3 50-24-8 5755
5
Miconazole Approved, Investigational, Vet_approved Phase 3 22916-47-8 4189
6 Antidotes Phase 3
7 Anti-Infective Agents Phase 3,Phase 1
8 Antioxidants Phase 3
9 Antiviral Agents Phase 3
10 Expectorants Phase 3
11 Liver Extracts Phase 3
12 Methylprednisolone acetate Phase 3
13 Methylprednisolone Hemisuccinate Phase 3
14 N-monoacetylcystine Phase 3
15 Prednisolone acetate Phase 3
16 Prednisolone hemisuccinate Phase 3
17 Prednisolone phosphate Phase 3
18 Protective Agents Phase 3
19 Respiratory System Agents Phase 3
20 Antifungal Agents Phase 3
21 Antirheumatic Agents Phase 3
22 Calcineurin Inhibitors Phase 3
23 Cyclosporins Phase 3
24 Dermatologic Agents Phase 3
25 Immunosuppressive Agents Phase 3
26 Pharmaceutical Solutions Phase 3
27 cysteine Nutraceutical Phase 3
28
Uric Acid Experimental, Investigational Phase 1 69-93-2 1175
29 Anti-Infective Agents, Local Phase 1
30 Central Nervous System Depressants Phase 1
31 Adrenergic Agents Phase 1
32 Atomoxetine Hydrochloride Phase 1
33 Neurotransmitter Agents Phase 1
34 Neurotransmitter Uptake Inhibitors Phase 1
35 Tea Nutraceutical Phase 1
36
Prazosin Approved 19216-56-9 4893

Interventional clinical trials:


id Name Status NCT ID Phase Drugs
1 Treatment of Severe Alcoholic Hepatitis With Corticoids Plus N Acetyl Cysteine Versus Corticoids Alone Completed NCT00863785 Phase 3 Corticoids plus N Acetyl Cysteine
2 CYCLosporinE A in Reperfused Acute Myocardial Infarction Completed NCT01650662 Phase 3 Cyclosporine A
3 Postprandial Effect of Chinese Tea Flavor Liquor on Selected CVD Risk Factors Completed NCT01264666 Phase 1
4 A Gene by Medication Interaction to the Acute Effects of Alcohol Terminated NCT01343628 Phase 1 Placebo Comparator;Active Comparator: Atomoxetine, Placebo
5 A Dose Response Effect of Atomoxetine to the Acute Effects of Alcohol Terminated NCT01408589 Phase 1 Atomoxetine, Strattera
6 Alcohol Effects on Driving-related Skills of Young Drivers Completed NCT02710578 Alcohol;Placebo
7 Influence of Age and Sex on Alcohol Metabolism and Acute Responses Completed NCT00070577
8 Alcohol Exposure and Airway Hyperresponsiveness Completed NCT00990275
9 Multimodal Neuroimaging of Stress and Reward Cues to Assess Alcoholism Risk and Relapse Recruiting NCT02616094

Search NIH Clinical Center for Alcohol Sensitivity, Acute

Genetic Tests for Alcohol Sensitivity, Acute

Genetic tests related to Alcohol Sensitivity, Acute:

id Genetic test Affiliating Genes
1 Acute Alcohol Sensitivity 29

Anatomical Context for Alcohol Sensitivity, Acute

MalaCards organs/tissues related to Alcohol Sensitivity, Acute:

39
Skin, Liver

Publications for Alcohol Sensitivity, Acute

Variations for Alcohol Sensitivity, Acute

ClinVar genetic disease variations for Alcohol Sensitivity, Acute:

6
id Gene Variation Type Significance SNP ID Assembly Location
1 ALDH2 NM_000690.3(ALDH2): c.1510G> A (p.Glu504Lys) single nucleotide variant Pathogenic,protective,risk factor rs671 GRCh37 Chromosome 12, 112241766: 112241766

Expression for Alcohol Sensitivity, Acute

Search GEO for disease gene expression data for Alcohol Sensitivity, Acute.

Pathways for Alcohol Sensitivity, Acute

GO Terms for Alcohol Sensitivity, Acute

Sources for Alcohol Sensitivity, Acute

3 CDC
7 CNVD
9 Cosmic
10 dbSNP
11 DGIdb
16 ExPASy
18 FMA
28 GO
29 GTR
30 HGMD
31 HMDB
32 HPO
33 ICD10
34 ICD10 via Orphanet
35 ICD9CM
36 IUPHAR
37 KEGG
38 LifeMap
40 MedGen
42 MeSH
43 MESH via Orphanet
44 MGI
46 NCI
47 NCIt
48 NDF-RT
51 NINDS
52 Novoseek
54 OMIM
55 OMIM via Orphanet
59 PubMed
60 QIAGEN
65 SNOMED-CT via HPO
66 SNOMED-CT via Orphanet
67 TGDB
68 Tocris
69 UMLS
70 UMLS via Orphanet
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