MCID: ALC016
MIFTS: 19

Alcohol Sensitivity, Acute malady

Categories: Genetic diseases, Rare diseases, Mental diseases

Aliases & Classifications for Alcohol Sensitivity, Acute

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Aliases & Descriptions for Alcohol Sensitivity, Acute:

Name: Alcohol Sensitivity, Acute 49 11
Acute Alcohol Sensitivity 45 24
Hangover, Susceptibility to 45
 
Alcohol Intolerance 45
Hangover 49

Classifications:



External Ids:

OMIM49 610251

Summaries for Alcohol Sensitivity, Acute

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NIH Rare Diseases:45 Alcohol intolerance is characterized by immediate unpleasant reactions after drinking alcohol. the most common signs and symptoms of alcohol intolerance are stuffy nose and skin flushing. alcohol intolerance is caused by a genetic condition in which the body is unable to break down alcohol efficiently, usually found in asians. these individuals accumulate acetaldehyde, the primary metabolite of ethanol, because of a genetic polymorphism of aldehyde dehydrogenase (aldh) that metabolizes acetaldehyde to nontoxic acetate. the only way to prevent alcohol intolerance reactions is to avoid alcohol. alcohol intolerance isn't an allergy. however, in some cases, what seems to be alcohol intolerance may be a reaction to something in an alcoholic beverage, such as chemicals, grains or preservatives. combining alcohol with certain medications also can cause reactions. in rare instances, an unpleasant reaction to alcohol can be a sign of a serious underlying health problem that requires diagnosis and treatment. last updated: 6/26/2015

MalaCards based summary: Alcohol Sensitivity, Acute, is also known as acute alcohol sensitivity, and has symptoms including facial flushing after alcohol intakeand delayed oxidation of acetaldehyde. An important gene associated with Alcohol Sensitivity, Acute is ALDH2 (Aldehyde Dehydrogenase 2 Family (Mitochondrial)). Affiliated tissues include skin, liver and breast.

Description from OMIM:49 610251

Related Diseases for Alcohol Sensitivity, Acute

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Diseases in the Alcohol Abuse family:

alcohol sensitivity, acute

Symptoms for Alcohol Sensitivity, Acute

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Clinical features from OMIM:

610251

HPO human phenotypes related to Alcohol Sensitivity, Acute:

id Description Frequency HPO Source Accession
1 facial flushing after alcohol intake HP:0001033
2 delayed oxidation of acetaldehyde HP:0003533

Drugs & Therapeutics for Alcohol Sensitivity, Acute

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Drugs for Alcohol Sensitivity, Acute (from DrugBank, HMDB, Dgidb, PharmGKB, IUPHAR, NovoSeek, BitterDB):

(show all 10)
idNameStatusPhaseClinical TrialsCas NumberPubChem Id
1Phase 1
2Contraceptives, OralPhase 13734
3Adrenergic AgentsPhase 14204
4Neurotransmitter Uptake InhibitorsPhase 12857
5Atomoxetine HydrochloridePhase 1160
6Neurotransmitter AgentsPhase 114795
7Liver Extracts3572
8Central Nervous System Depressants10016
9Anti-Infective Agents, Local984
10Anti-Infective Agents17220

Interventional clinical trials:

idNameStatusNCT IDPhase
1Pregnenolone and Marijuana DependenceRecruitingNCT02439814Phase 2
2A Gene by Medication Interaction to the Acute Effects of AlcoholTerminatedNCT01343628Phase 1
3A Dose Response Effect of Atomoxetine to the Acute Effects of AlcoholTerminatedNCT01408589Phase 1
4Prognostic Indicators as Provided by the EPIC ClearViewCompletedNCT01476995
5Alcohol Effects on Driving-related Skills of Young DriversRecruitingNCT02710578

Search NIH Clinical Center for Alcohol Sensitivity, Acute

Genetic Tests for Alcohol Sensitivity, Acute

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Anatomical Context for Alcohol Sensitivity, Acute

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MalaCards organs/tissues related to Alcohol Sensitivity, Acute:

33
Skin, Liver, Breast

Animal Models for Alcohol Sensitivity, Acute or affiliated genes

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Publications for Alcohol Sensitivity, Acute

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Variations for Alcohol Sensitivity, Acute

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Clinvar genetic disease variations for Alcohol Sensitivity, Acute:

5
id Gene Variation Type Significance SNP ID Assembly Location
1ALDH2NM_000690.3(ALDH2): c.1510G> A (p.Glu504Lys)single nucleotide variantPathogenic, protective, risk factorrs671GRCh37Chr 12, 112241766: 112241766

Expression for genes affiliated with Alcohol Sensitivity, Acute

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Search GEO for disease gene expression data for Alcohol Sensitivity, Acute.

Pathways for genes affiliated with Alcohol Sensitivity, Acute

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GO Terms for genes affiliated with Alcohol Sensitivity, Acute

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Sources for Alcohol Sensitivity, Acute

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2CDC
14ExPASy
15FDA
16FMA
24GTR
25HGMD
26HMDB
27ICD10
28ICD10 via Orphanet
29ICD9CM
30IUPHAR
31KEGG
34MedGen
36MeSH
37MESH via Orphanet
38MGI
41NCI
42NCIt
43NDF-RT
46NINDS
47Novoseek
49OMIM
50OMIM via Orphanet
54PubMed
55QIAGEN
60SNOMED-CT via Orphanet
64Tumor Gene Family of Databases
65UMLS
66UMLS via Orphanet