MCID: ALC010
MIFTS: 48

Alcoholic Cardiomyopathy malady

Cardiovascular diseases category

Summaries for Alcoholic Cardiomyopathy

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63Wikipedia, 32MalaCards
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Wikipedia:63 Alcoholic cardiomyopathy is a disease in which the chronic long-term abuse of alcohol (i.e. ethanol)... more...

MalaCards: Alcoholic Cardiomyopathy, also known as dilated cardiomyopathy secondary to alcohol, is related to alcohol dependence and hypertension. An important gene associated with Alcoholic Cardiomyopathy is MSTN (myostatin), and among its related pathways are beta-Alanine metabolism and tryptophan utilization II. The compounds ad-5061 and farglitazar have been mentioned in the context of this disorder. Affiliated tissues include heart and liver, and related mouse phenotypes are adipose tissue and tumorigenesis.

Aliases & Classifications for Alcoholic Cardiomyopathy

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8Disease Ontology, 60UMLS, 39NCIt, 56SNOMED-CT, 34MeSH, 27ICD9CM, 25ICD10
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Classifications:

Malacards categories (disease lists): (See all malacards categories)
Anatomical: Cardiovascular diseases


Aliases & Descriptions:

alcoholic cardiomyopathy 8
dilated cardiomyopathy secondary to alcohol 8
alcohol-induced heart muscle disease 8
cardiomyopathy, alcoholic 60


External Ids:

Disease Ontology8 DOID:12935
NCIt39 C53653
MeSH34 D002310
SNOMED-CT56 155352001, 83521008
ICD9CM27 425.5
ICD1025 I42.6

Related Diseases for Alcoholic Cardiomyopathy

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17GeneCards, 18GeneDecks
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Diseases related to Alcoholic Cardiomyopathy via text searches within MalaCards or GeneCards/GeneDecks gene sharing:

(show top 50)    (show all 69)
idRelated DiseaseScoreTop Affiliating Genes
1alcohol dependence30.2ALDH2
2hypertension30.1ACE, PPARG, PPARA
3myopathy29.9MSTN, PPARA
4liver cirrhosis29.9AKR1A1, ALDH2
5hypertensive heart disease29.9PPARA, ACE
6alcoholic liver cirrhosis29.9ALDH2, AKR1A1
7coronary artery disease29.9PPARA, PPARG, ACE
8hypertrophic cardiomyopathy10.3
9dilated cardiomyopathy10.2
10neuropathy10.0MSTN
11hepatitis10.0AKR1A1
12hyperhomocysteinemia10.0APOH
13vascular disease10.0APOH
14stroke, ischemic10.0APOH
15retinal artery occlusion10.0APOH
16cystic fibrosis10.0ACADM
17thromboembolism10.0APOH
18dermatitis10.0PPARA
19rheumatoid arthritis10.0APOH
20acute myocardial infarction10.0ACE
21vasculitis10.0APOH
22fetal alcohol spectrum disorder10.0AKR1A1
23acute pancreatitis10.0ALDH2
24asthma10.0ALDH2
25esophageal cancer10.0ALDH2
26gastritis10.0AKR1A1
27dementia10.0ALDH2
28tuberculosis10.0AKR1A1
29arthritis10.0PPARA
30schizophrenia10.0PPARA
31pancreatitis10.0ALDH2
32migraine10.0APOH
33retinal vein occlusion10.0APOH
34arteriosclerosis10.0PPARG
35sarcoidosis10.0ACE
36hypercholesterolemia10.0PPARA, ACE
37heart lymphoma10.0
38hypersplenism10.0
39liver disease10.0
40myocarditis10.0
41alcoholic pancreatitis10.0ALDH2, AKR1A1
42sudden cardiac death multi-gene panels10.0ACADM, ACE
43hepatitis b10.0ALDH2, PPARA
44squamous cell carcinoma10.0ALDH2
45adenocarcinoma10.0ALDH2, PPARA
46noonan syndrome10.0ACADM, ACE, AKR1A1
47fatty liver disease10.0PPARA, PPARG
48polycystic ovary syndrome10.0PPARG, PPARA
49glucose intolerance10.0PPARA, PPARG
50hypertriglyceridemia10.0PPARG, PPARA

Graphical network of the top 20 diseases related to Alcoholic Cardiomyopathy:



Diseases related to alcoholic cardiomyopathy

Clinical Features for Alcoholic Cardiomyopathy

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Drugs & Therapeutics for Alcoholic Cardiomyopathy

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Sources:
5CenterWatch, 41NIH Clinical Center, 6ClinicalTrials
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Approved drugs:

Search CenterWatch for Alcoholic Cardiomyopathy

Drug clinical trials:

Search ClinicalTrials for Alcoholic Cardiomyopathy

Search NIH Clinical Center for Alcoholic Cardiomyopathy

Search CenterWatch for Alcoholic Cardiomyopathy

Genetic Tests for Alcoholic Cardiomyopathy

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Anatomical Context for Alcoholic Cardiomyopathy

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32MalaCards
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MalaCards organs/tissues related to Alcoholic Cardiomyopathy:

32
Heart, Liver

Animal Models for Alcoholic Cardiomyopathy or affiliated genes

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36MGI
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MGI Mouse Phenotypes related to Alcoholic Cardiomyopathy:

36
idDescriptionMGI Source AccessionScoreTop Affiliating Genes
1MP:00053758.9MSTN, ACE, PPARA
2MP:00020068.1TNXB, PPARG, ALDH2, ACE
3MP:00053708.0ACE, MSTN, ACADM, PPARA, PPARG
4MP:00053877.1PPARA, MSTN, ACE, AKR1A1, PPARG, ALDH2
5MP:00053846.9ALDH2, MSTN, ACE, PPARA, PPARG, AKR1A1
6MP:00053766.6PPARA, PPARG, ACE, ALDH2, MSTN, APOH
7MP:00107686.2ALDH2, TNXB, APOH, PPARA, PPARG, AKR1A1

Publications for Alcoholic Cardiomyopathy

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Sources:
50PubMed
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Articles related to Alcoholic Cardiomyopathy:

(show top 50)    (show all 154)
idTitleAuthorsYear
1
Alcoholic cardiomyopathy and cardiovascular events - an insight from the Liptov region. (23731046)
2013
2
Invasive thoughts: honoring two decades of alcohol septal ablation for hypertrophic cardiomyopathy. (23913599)
2013
3
Reversible left ventricular apical ballooning after heavy alcohol consumption in a patient with hypertrophic cardiomyopathy. (23164586)
2013
4
Septal perforator anatomy and variability of perfusion bed by myocardial contrast echocardiography: a study of hypertrophic cardiomyopathy patients undergoing alcohol septal ablation. (24118133)
2013
5
Tako-tsubo cardiomyopathy precipitated by alcohol withdrawal. (22298173)
2012
6
Survival after alcohol septal ablation for obstructive hypertrophic cardiomyopathy. (23076968)
2012
7
Videodensitometric time-density curve change after alcohol septal ablation of obstructive hypertrophic cardiomyopathy. (23184598)
2012
8
Chronic alcohol intake-induced oxidative stress and apoptosis: role of CYP2E1 and calpain-1 in alcoholic cardiomyopathy. (21833537)
2012
9
Increased myostatin activity and decreased myocyte proliferation in chronic alcoholic cardiomyopathy. (21463333)
2011
10
Functional proteomic analysis reveals sex-dependent differences in structural and energy-producing myocardial proteins in rat model of alcoholic cardiomyopathy. (21245415)
2011
11
Tenascin-x facilitates myocardial fibrosis and cardiac remodeling through transforming growth factor-I^1 and peroxisome proliferator-activated receptor I^ in alcoholic cardiomyopathy. (21362339)
2011
12
Evaluation of myocyte proliferation in alcoholic cardiomyopathy: telomerase enzyme activity (TERT) compared with Ki-67 expression. (21733836)
2011
13
WITHDRAWN: Oxidative stress-induced apoptosis is mediated by calpains in alcoholic cardiomyopathy. (21172724)
2010
14
L-carnitine and cardiac metabolism and remodeling indices in alcoholic cardiomyopathy]. (19080238)
2008
15
Acetaldehyde and alcoholic cardiomyopathy: lessons from the ADH and ALDH2 transgenic models. (17590987)
2007
16
The effect of controlled drinking in alcoholic cardiomyopathy. (11827495)
2002
17
Alcoholic cardiomyopathy versus chronic myocarditis--immunohistological investigations with LCA, CD3, CD68 and tenascin. (11955834)
2002
18
Treatment of heart failure and ascites with ultrafiltration in patients with intractable alcoholic cardiomyopathy. (11887087)
2002
19
Alcoholic cardiomyopathy: is it dose-dependent? (12461319)
2002
20
Alcoholic cardiomyopathy; hypertension. (10977447)
2000
21
Point mutations in mitochondrial DNA of patients with alcoholic cardiomyopathy. (11471656)
2000
22
Alcoholic cardiomyopathy. (8086332)
1994
23
Rarity of preclinical alcoholic cardiomyopathy in chronic alcoholics less than 40 years of age. (1987720)
1991
24
Chronic alcoholic cardiomyopathy. Protection of the isolated ischaemic working heart by ribose. (3151053)
1988
25
Gated radionuclide angiocardiography in the noninvasive evaluation of a partially reversible alcoholic cardiomyopathy. (3728516)
1986
26
Recurrent hypersplenism caused by alcoholic cardiomyopathy after distal splenorenal shunt. (3952675)
1986
27
Effect of chronic ethanol ingestion on the metabolism of copper, iron, manganese, selenium, and zinc in an animal model of alcoholic cardiomyopathy. (6502742)
1984
28
Alcoholic cardiomyopathy. (6093193)
1984
29
Liver disease in alcoholic cardiomyopathy: evidence against cirrhosis. (6840753)
1983
30
Alcoholic cardiomyopathy. (6913436)
1981
31
Alcoholic cardiomyopathy. (7245114)
1981
32
Alcohol and malnutrition in the pathogenesis of experimental alcoholic cardiomyopathy. (7370094)
1980
33
Electrophysiological properties of right heart and atrioventricular conducting system in patients with alcoholic cardiomyopathy. (508449)
1979
34
Reversibility of alcoholic cardiomyopathy with abstention from alcohol. (476737)
1979
35
Alcoholic cardiomyopathy: the effect of ethanol and acetaldehyde on cardiac protein synthesis. (1241620)
1975
36
Mitochondrial function and excitation-contraction coupling in the development of alcoholic cardiomyopathy. (1237922)
1975
37
Editorial: Alcoholic cardiomyopathy. (4441876)
1974
38
The incidence of myocardial abnormalities in man related to the level of ethanol consumption. A proposal of a diagnostic criterion of alcoholic cardiomyopathy. (4140250)
1974
39
Letter: Alcoholic cardiomyopathy. (4277554)
1974
40
Heart block in alcoholic cardiomyopathy. (4413642)
1974
41
The natural course of alcoholic cardiomyopathy. (4273902)
1974
42
Alcoholic cardiomyopathy: an introductory review. (4550483)
1972
43
Alcoholic cardiomyopathy managed with prolonged bed rest. (4254303)
1971
44
Alcoholic cardiomyopathy: a critical review. (4921395)
1970
45
Alcoholic cardiomyopathy. (4166114)
1967
46
ALCOHOLIC CARDIOMYOPATHY; A HISTOCHEMICAL STUDY. (14296641)
1965
47
ALCOHOLIC CARDIOMYOPATHY; AN ELECTRON MICROSCOPIC STUDY. (14296642)
1965
48
Alcoholic cardiomyopathy. (14447338)
1961
49
The electrocardiogram of alcoholic cardiomyopathy. (13821022)
1959
50
Alcoholic cardiomyopathy in a man with Gaustad's syndrome. (13586663)
1958

Genetic Variations for Alcoholic Cardiomyopathy

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Expression for genes affiliated with Alcoholic Cardiomyopathy

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Sources:
1BioGPS, 15Gene Expression Omnibus DataSets
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Expression patterns in normal tissues for genes affiliated with Alcoholic Cardiomyopathy

Search GEO for disease gene expression data for Alcoholic Cardiomyopathy.

Pathways for genes affiliated with Alcoholic Cardiomyopathy

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Sources:
29KEGG, 37NCBI BioSystems Database, 49PharmGKB, 53Reactome
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Compounds for genes affiliated with Alcoholic Cardiomyopathy

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Sources:
28IUPHAR, 44Novoseek, 11DrugBank, 59Tocris Bioscience, 49PharmGKB, 24HMDB
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Compounds related to Alcoholic Cardiomyopathy according to GeneCards/GeneDecks:

(show top 50)    (show all 98)
idCompoundScoreTop Affiliating Genes
1ad-5061289.8PPARA, PPARG
2farglitazar289.8PPARG, PPARA
3tzd18289.8PPARG, PPARA
4reglitazar289.8PPARG, PPARA
5mk-0767289.8PPARG, PPARA
6ly-465608289.8PPARG, PPARA
7ly-510929289.8PPARA, PPARG
8gw 1929449.8PPARG, PPARA
9gi262570449.8PPARG, PPARA
10ragaglitazar44 2810.8PPARG, PPARA
11mono(2-ethylhexyl)phthalate449.8PPARG, PPARA
12gw409544289.8PPARG, PPARA
13ALEGLITAZAR 119.8PPARA, PPARG
14gw9578289.8PPARA, PPARG
15tetradecylthioacetic acid449.8PPARA, PPARG
16gw 764744 5910.8PPARA, PPARG
17bisphenol a diglycidyl ether449.8PPARA, PPARG
183-{5-methoxy-1-[(4-methoxyphenyl)sulfonyl]-1H-indol-3-yl}propanoic acid119.7PPARA, PPARG
19gw50151644 2810.7PPARA, PPARG
20tesaglitazar449.7PPARA, PPARG
21prostaglandin j2449.7PPARA, PPARG
22propionaldehyde449.7AKR1A1, ALDH2
23palmitoylethanolamide28 44 5911.7PPARA, PPARG
24muraglitazar49 4410.7PPARA, PPARG
25benzaldehyde44 2410.6ALDH2, AKR1A1
26octanoate449.5ACADM, PPARG, PPARA
27acetaldehyde44 28 2411.3ALDH2, AKR1A1, PPARA
28carnitine449.3PPARA, PPARG, ACADM
294-hydroxynonenal44 2410.2ALDH2, AKR1A1, PPARA
302-methylbutyryl-coa44 2410.2ACADM, PPARG, PPARA
31octanoyl-coa44 2410.2PPARA, PPARG, ACADM
32(2E)-Tetradecenoyl-CoA249.2PPARA, PPARG, ACADM
33(2E)-Octenoyl-CoA249.1PPARA, PPARG, ACADM
34phenobarbital44 28 1111.1AKR1A1, PPARG, PPARA
35(2E)-Dodecenoyl-CoA249.1PPARA, PPARG, ACADM
36stearoyl-coa44 2410.1PPARA, PPARG, ACADM
37folate449.0ALDH2, AKR1A1, PPARA, APOH
38telmisartan44 28 1111.0ACE, PPARG, PPARA
39(2E)-Decenoyl-CoA249.0PPARA, PPARG, ACADM
40metformin44 49 1110.9ACE, PPARG, PPARA
41(2E)-Hexadecenoyl-CoA248.8PPARG, ACADM, PPARA
42retinoid448.7PPARA, PPARG, AKR1A1, ALDH2
43prostacyclin448.6APOH, PPARA, PPARG, ACE
44aspirin44 49 28 2411.6APOH, PPARA, PPARG, ACE
45arginine448.6ALDH2, ACADM, AKR1A1, PPARA, APOH
46glutamate448.5ALDH2, ACADM, AKR1A1, PPARA, APOH
47creatinine448.2APOH, PPARA, AKR1A1, ACE, ALDH2
48cholesterol44 28 11 2411.0APOH, PPARA, PPARG, ACE, ALDH2
49glucose447.5ALDH2, APOH, PPARA, PPARG, ACE, ACADM
50lipid447.3APOH, PPARA, PPARG, AKR1A1, ACE, ACADM

GO Terms for genes affiliated with Alcoholic Cardiomyopathy

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16Gene Ontology
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Cellular components related to Alcoholic Cardiomyopathy according to GeneCards/GeneDecks:

idNameGO IDScoreTop Affiliating Genes
1extracellular spaceGO:0056158.5MSTN, ACE, APOH, TNXB

Biological processes related to Alcoholic Cardiomyopathy according to GeneCards/GeneDecks:

(show all 7)
idNameGO IDScoreTop Affiliating Genes
1triglyceride metabolic processGO:0066419.7APOH, TNXB
2negative regulation of receptor biosynthetic processGO:0108719.5PPARG, PPARA
3negative regulation of sequestering of triglycerideGO:0108919.5PPARG, PPARA
4positive regulation of fatty acid oxidationGO:0463219.5PPARG, PPARA
5negative regulation of cholesterol storageGO:0108879.4PPARA, PPARG
6negative regulation of macrophage derived foam cell differentiationGO:0107459.3PPARG, PPARA
7response to coldGO:0094099.2ACADM, PPARG

Molecular functions related to Alcoholic Cardiomyopathy according to GeneCards/GeneDecks:

idNameGO IDScoreTop Affiliating Genes
1steroid hormone receptor activityGO:0037079.4PPARG, PPARA
2heparin bindingGO:0082019.3TNXB, APOH, MSTN
3ligand-activated sequence-specific DNA binding RNA polymerase II transcription factor activityGO:0048799.1PPARG, PPARA
4drug bindingGO:0081448.6ACE, PPARG, PPARA

Products for genes affiliated with Alcoholic Cardiomyopathy

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  • Antibodies
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Sources for Alcoholic Cardiomyopathy

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3CDC
13ExPASy
14FMA
22GTR
23HGMD
24HMDB
25ICD10
26ICD10 via Orphanet
27ICD9CM
28IUPHAR
29KEGG
34MeSH
35MESH via Orphanet
36MGI
39NCIt
40NDF-RT
43NINDS
44Novoseek
46OMIM
47OMIM via Orphanet
50PubMed
51QIAGEN
57SNOMED-CT via Orphanet
60UMLS
61UMLS via Orphanet