MCID: ALC010
MIFTS: 38

Alcoholic Cardiomyopathy malady

Category: Cardiovascular diseases

Aliases & Classifications for Alcoholic Cardiomyopathy

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Aliases & Descriptions for Alcoholic Cardiomyopathy:

Name: Alcoholic Cardiomyopathy 11 13
Cardiomyopathy, Alcoholic 39 68
 
Dilated Cardiomyopathy Secondary to Alcohol 11
Alcohol-Induced Heart Muscle Disease 11

Classifications:



External Ids:

Disease Ontology11 DOID:12935
ICD1030 I42.6
ICD9CM32 425.5
SNOMED-CT62 155352001, 83521008
MeSH39 D002310
NCIt45 C53653

Summaries for Alcoholic Cardiomyopathy

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Wikipedia:71 Alcoholic cardiomyopathy is a disease in which the chronic long-term abuse of alcohol (i.e., ethanol)... more...

MalaCards based summary: Alcoholic Cardiomyopathy, also known as cardiomyopathy, alcoholic, is related to cardiomyopathy and deafness, x-linked 5. An important gene associated with Alcoholic Cardiomyopathy is PPARA (Peroxisome Proliferator Activated Receptor Alpha), and among its related pathways are Nuclear receptors in lipid metabolism and toxicity and beta-Alanine metabolism (KEGG). Affiliated tissues include heart, liver and skeletal muscle, and related mouse phenotypes are adipose tissue and neoplasm.

Related Diseases for Alcoholic Cardiomyopathy

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Graphical network of the top 20 diseases related to Alcoholic Cardiomyopathy:



Diseases related to alcoholic cardiomyopathy

Symptoms & Phenotypes for Alcoholic Cardiomyopathy

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MGI Mouse Phenotypes related to Alcoholic Cardiomyopathy according to GeneCards Suite gene sharing:

41
idDescriptionMGI Source AccessionScoreTop Affiliating Genes
1MP:00053759.9ACE, MSTN, PPARA, PPARG
2MP:00020068.6ACE, ALDH2, PPARG, TNXB
3MP:00107688.1ACADM, ACE, ALDH2, MSTN, PPARA, PPARG
4MP:00053858.1ACADM, ACE, MSTN, PPARA, PPARG, RGS6
5MP:00053768.0ACADM, ACE, ALDH2, MSTN, PPARA, PPARG
6MP:00053708.0ACADM, ACE, ALDH2, MSTN, PPARA, PPARG

Drugs & Therapeutics for Alcoholic Cardiomyopathy

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Drugs for Alcoholic Cardiomyopathy (from DrugBank, HMDB, Dgidb, PharmGKB, IUPHAR, NovoSeek, BitterDB):

(show all 11)
idNameStatusPhaseClinical TrialsCas NumberPubChem Id
1
SpironolactoneapprovedPhase 42221952-01-7, 52-01-75833
Synonyms:
4-18-00-01601 (Beilstein Handbook Reference)
4-Pregnen-21-oic acid-17alpha-ol-3-one-7alpha-thiol gamma-lactone 7-acetate
496916-40-6
52-01-7
7-alpha-Acetylthio-3-oxo-17-alpha-pregn-4-ene-21,17-beta-carbolactone
7alpha-(acetylsulfanyl)-3-oxo-17alpha-pregn-4-ene-21,17-carbolactone
AB00513806
AC-4214
AC1L1L8Q
Abbolactone
Acelat
Aldace
Aldactazide
Aldactide
Aldactone
Aldactone (TN)
Aldactone A
Alderon
Aldopur
Almatol
Alphapharm Brand of Spironolactone
Alpharma Brand of Spironolactone
Alter Brand of Spironolactone
Altex
Aquareduct
Ashbourne Brand of Spironolactone
Azupharma Brand of Spironolactone
BIDD:PXR0071
BPBio1_000194
BRD-K90027355-001-03-4
BRN 0057767
BSPBio_000176
C07310
C24H32O4S
CHEBI:428201
CHEBI:45692
CHEBI:9241
CHEMBL1393
CID5833
CPD000471892
Cardel Brand of Spironolactone
D00443
D013148
DB00421
Deverol
Dexo Brand of Spironolactone
Diatensec
Dira
Duraspiron
EINECS 200-133-6
Espironolactona
Espironolactona Alter
Espironolactona Mundogen
Espironolactona [INN-Spanish]
Euteberol
Flumach
Frumikal
Generosan Brand of Spironolactone
HMS1568I18
HMS2090N21
HSDB 3184
Hormosan Brand of Spironolactone
I06-1970
Jenapharm Brand of Spironolactone
Jenaspiron
LS-118614
LT00772287
Lacalmin
Lacdene
Laractone
MLS001074672
MLS001333253
MLS001333254
MLS002153245
MLS002207058
Mayoly-Spindler Brand of Spironolactone
Melarcon
Merck dura Brand of Spironolactone
Mundogen Brand of Spironolactone
NCGC00164397-01
 
NCGC00164397-02
NSC 150399
NSC150399
Nefurofan
Novo Spiroton
Novo-Spiroton
NovoSpiroton
Novopharm Brand of Spironolactone
Osyrol
Pfizer Brand of Spironolactone
Pharmafrid Brand of Spironolactone
Practon
Prestwick0_000128
Prestwick1_000128
Prestwick2_000128
Prestwick3_000128
Roche Brand of Spironolactone
S0260
S3378_SIGMA
SAM002264648
SC 9420
SC-9420
SC9420
SMR000471892
SNL
SPBio_002115
Sagisal
Searle Brand of Spironolactone
Sincomen
Spiractin
Spiresis
Spiretic
Spiridon
Spiro L.U.T.
Spiro(17H-cyclopenta(a)phenauthrene-17,2'-(3'H)-furan)
Spiro-Tablinen
Spiro[17H-cyclopenta[a]phenauthrene-17,2'-(3'H)-furan]
Spirobeta
Spiroctan
Spiroctanie
Spiroderm
Spirogamma
Spirolactone
Spirolakton
Spirolang
Spirolone
Spirone
Spirono Isis
Spirono-Isis
Spironocompren
Spironolactone
Spironolactone (JP15/USP/INN)
Spironolactone A
Spironolactone [BAN:INN:JAN]
Spironolactone [INN:BAN:JAN]
Spironolactonum
Spironolactonum [INN-Latin]
Spironolattone
Spironolattone [DCIT]
Spironone
Spirospare
Sprioderm
Supra-puren
Suracton
UNII-27O7W4T232
Uractone
Urusonin
Veroshpiron
Verospiron
Verospirone
Verospirone Opianin
WLN: L E5 B666 FX OV MUTJ A1 E1 KSV1 F-& CT5VOXTJ
Worwag Brand of Spironolactone
Xenalon
ZINC03861599
betapharm Brand of Spironolactone
ct Arzneimittel Brand of Spironolactone
ct-Arzneimittel Brand of Spironolactone
spiro von ct
spironolactone
spironolattone
von ct, spiro
2MineralocorticoidsPhase 4352
3Natriuretic AgentsPhase 41645
4diureticsPhase 41372
5Mineralocorticoid Receptor AntagonistsPhase 4333
6Diuretics, Potassium SparingPhase 41827
7Hormones, Hormone Substitutes, and Hormone AntagonistsPhase 412767
8Hormone AntagonistsPhase 412778
9HormonesPhase 413979
10Liver Extracts3868
11Antioxidants2928

Interventional clinical trials:

idNameStatusNCT IDPhase
1Clinical Trial Studying the Effects of Spironolactone on Heart and Skeletal Muscle Function in Chronic AlcoholicsSuspendedNCT00226109Phase 4
2Prospective Analysis Of Cardiac Function In Cirrhotic Patients By Echocardiography And Its Correlation With EventsUnknown statusNCT01433848
3Subclinical Myocardial Dysfunction in Patients With Hepatic CirrhosisCompletedNCT01713478
4Adapted Physical Activity Effect on Aerobic Function and in Patients in Pre Liver TransplantationRecruitingNCT02567591

Search NIH Clinical Center for Alcoholic Cardiomyopathy


Cochrane evidence based reviews: cardiomyopathy, alcoholic

Genetic Tests for Alcoholic Cardiomyopathy

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Anatomical Context for Alcoholic Cardiomyopathy

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MalaCards organs/tissues related to Alcoholic Cardiomyopathy:

36
Heart, Liver, Skeletal muscle

Publications for Alcoholic Cardiomyopathy

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Articles related to Alcoholic Cardiomyopathy:

(show top 50)    (show all 144)
idTitleAuthorsYear
1
NOX2 amplifies acetaldehyde-mediated cardiomyocyte mitochondrial dysfunction in alcoholic cardiomyopathy. (27624556)
2016
2
Alcoholic cardiomyopathy : The result of dosage and individual predisposition. (27582365)
2016
3
Left Ventricular Strain and Rotation by 2-D Speckle Tracking Echocardiography Identify Early Alcoholic Cardiomyopathy. (27156014)
2016
4
Perioperative detection of alcoholic cardiomyopathy: cases and recommendations. (27720475)
2016
5
Enzymes and signal pathways in the pathogenesis of alcoholic cardiomyopathy. (27418001)
2016
6
Investigation of microRNA Expression Profiles Associated with Human Alcoholic Cardiomyopathy. (25791397)
2015
7
Natural history and prognostic factors in alcoholic cardiomyopathy. (25458176)
2015
8
Malignant ventricular arrhythmias in alcoholic cardiomyopathy. (26188828)
2015
9
Alcoholic cardiomyopathy. (25228956)
2014
10
Alcoholic cardiomyopathy: pathophysiologic insights. (24671642)
2014
11
A case of heart failure due to alcoholic cardiomyopathy combined with acute pulmonary embolism. (25276392)
2014
12
Alcoholic Cardiomyopathy: Multigenic Changes Underlie Cardiovascular Dysfunction. (26478905)
2014
13
Alcoholic cardiomyopathy. (24155001)
2013
14
Alcoholic cardiomyopathy and cardiovascular events - an insight from the Liptov region. (23731046)
2013
15
Quadri-chamber cardiac thrombi in alcoholic cardiomyopathy: a rare though ominous finding. (23708237)
2013
16
Chronic alcohol intake-induced oxidative stress and apoptosis: role of CYP2E1 and calpain-1 in alcoholic cardiomyopathy. (21833537)
2012
17
Sensitization to cross-reactive carbohydrate determinants in 2 patients with Hymenoptera venom allergy and alcoholic cardiomyopathy. (22901863)
2012
18
Alcoholic cardiomyopathy: a review. (21962423)
2011
19
Increased myostatin activity and decreased myocyte proliferation in chronic alcoholic cardiomyopathy. (21463333)
2011
20
Tenascin-x facilitates myocardial fibrosis and cardiac remodeling through transforming growth factor-I^1 and peroxisome proliferator-activated receptor I^ in alcoholic cardiomyopathy. (21362339)
2011
21
Evaluation of myocyte proliferation in alcoholic cardiomyopathy: telomerase enzyme activity (TERT) compared with Ki-67 expression. (21733836)
2011
22
Functional proteomic analysis reveals sex-dependent differences in structural and energy-producing myocardial proteins in rat model of alcoholic cardiomyopathy. (21245415)
2011
23
Carnitine regulates myocardial metabolism by Peroxisome Proliferator-Activated Receptor-alpha (PPARalpha) in alcoholic cardiomyopathy. (21169901)
2011
24
With computed tomography confirmed anterolateral left ventricular pseudoaneurysm in patient with dilatative alcoholic cardiomyopathy. (22933953)
2011
25
Dilated alcoholic cardiomyopathy and incidental lymphoma occuring in a 56 year old man who was being managed for hypertensive heart disease in Enugu Nigeria--a rare finding. (22288332)
2011
26
A dilated alcoholic cardiomyopathy. (19324436)
2011
27
Alcoholic cardiomyopathy. (20308914)
2010
28
WITHDRAWN: Oxidative stress-induced apoptosis is mediated by calpains in alcoholic cardiomyopathy. (21172724)
2010
29
Anticardiolipin antibodies associated with alcoholic cardiomyopathy. (18666184)
2009
30
Alcoholic cardiomyopathy: acetaldehyde, insulin insensitization and ER stress. (18479704)
2008
31
Expression of renin-angiotensin system and peroxisome proliferator-activated receptors in alcoholic cardiomyopathy. (18783396)
2008
32
Diving-related pulmonary oedema as an unusual presentation of alcoholic cardiomyopathy. (22692709)
2008
33
L-carnitine and cardiac metabolism and remodeling indices in alcoholic cardiomyopathy]. (19080238)
2008
34
Acetaldehyde and alcoholic cardiomyopathy: lessons from the ADH and ALDH2 transgenic models. (17590987)
2007
35
Angiotensin II type 1 receptor blockade prevents alcoholic cardiomyopathy. (16831986)
2006
36
Scintigraphic evaluation of cardiac metabolism and sympathetic nerve function in alcoholic cardiomyopathy. (16679703)
2006
37
Evidence of apoptosis in alcoholic cardiomyopathy. (16867874)
2006
38
A murine model of alcoholic cardiomyopathy: a role for zinc and metallothionein in fibrosis. (16049317)
2005
39
Pregnancy outcome in a mother with alcoholic cardiomyopathy. (16029303)
2005
40
Ethanol and acetaldehyde in alcoholic cardiomyopathy: from bad to ugly en route to oxidative stress. (15282111)
2004
41
Experimental Assessment of the Role of Acetaldehyde in Alcoholic Cardiomyopathy. (12734561)
2003
42
Alcoholic cardiomyopathy and ventricular arrhythmias. (12684336)
2003
43
The effect of controlled drinking in alcoholic cardiomyopathy. (11827495)
2002
44
Treatment of heart failure and ascites with ultrafiltration in patients with intractable alcoholic cardiomyopathy. (11887087)
2002
45
Alcoholic cardiomyopathy: incidence, clinical characteristics, and pathophysiology. (12006456)
2002
46
Alcoholic cardiomyopathy: is it dose-dependent? (12461319)
2002
47
Gender differences in alcoholic cardiomyopathy. (11859686)
2002
48
Alcoholic cardiomyopathy versus chronic myocarditis--immunohistological investigations with LCA, CD3, CD68 and tenascin. (11955834)
2002
49
Angiotensin-converting enzyme gene polymorphism is associated with vulnerability to alcoholic cardiomyopathy. (12204015)
2002
50
Echocardiographic evolution of left ventricular and left atrial thrombi in a patient with left ventricular dysfunction due to alcoholic cardiomyopathy, chronic atrial fibrillation and multiple non-fatal systemic embolisms. (11357926)
2001

Variations for Alcoholic Cardiomyopathy

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Expression for genes affiliated with Alcoholic Cardiomyopathy

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Search GEO for disease gene expression data for Alcoholic Cardiomyopathy.

Pathways for genes affiliated with Alcoholic Cardiomyopathy

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Pathways related to Alcoholic Cardiomyopathy according to GeneCards Suite gene sharing:

idSuper pathwaysScoreTop Affiliating Genes
19.8PPARA, PPARG
2
Show member pathways
9.5ACADM, ALDH2
39.3ACADM, PPARA, PPARG

GO Terms for genes affiliated with Alcoholic Cardiomyopathy

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Biological processes related to Alcoholic Cardiomyopathy according to GeneCards Suite gene sharing:

(show all 15)
idNameGO IDScoreTop Affiliating Genes
1negative regulation of protein bindingGO:003209110.4ACE, PPARA
2negative regulation of cholesterol storageGO:001088710.4PPARA, PPARG
3negative regulation of macrophage derived foam cell differentiationGO:001074510.4PPARA, PPARG
4negative regulation of receptor biosynthetic processGO:001087110.4PPARA, PPARG
5negative regulation of sequestering of triglycerideGO:001089110.4PPARA, PPARG
6positive regulation of fatty acid oxidationGO:004632110.4PPARA, PPARG
7regulation of blood pressureGO:000821710.3ACE, PPARG
8regulation of circadian rhythmGO:004275210.3PPARA, PPARG
9lipid homeostasisGO:005508810.3ACADM, PPARG
10fatty acid metabolic processGO:000663110.2PPARA, TNXB
11response to coldGO:000940910.2ACADM, PPARG
12response to starvationGO:004259410.1ACADM, PPARG
13heart developmentGO:000750710.0ACADM, PPARA, PPARG
14macrophage derived foam cell differentiationGO:00107429.9PPARG, SOAT2
15steroid hormone mediated signaling pathwayGO:00434019.8PPARA, PPARG

Molecular functions related to Alcoholic Cardiomyopathy according to GeneCards Suite gene sharing:

idNameGO IDScoreTop Affiliating Genes
1RNA polymerase II transcription factor activity, ligand-activated sequence-specific DNA bindingGO:000487910.2PPARA, PPARG
2drug bindingGO:000814410.0ACE, PPARA, PPARG
3steroid hormone receptor activityGO:00037079.8PPARA, PPARG
4fatty-acyl-CoA bindingGO:00000629.7ACADM, SOAT2

Sources for Alcoholic Cardiomyopathy

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2CDC
6CNVD
10DGIdb
15ExPASy
16FDA
17FMA
27GTR
28HGMD
29HMDB
30ICD10
31ICD10 via Orphanet
32ICD9CM
33IUPHAR
34KEGG
37MedGen
39MeSH
40MESH via Orphanet
41MGI
44NCI
45NCIt
46NDF-RT
49NINDS
50Novoseek
52OMIM
53OMIM via Orphanet
57PubMed
58QIAGEN
63SNOMED-CT via Orphanet
67Tumor Gene Family of Databases
68UMLS
69UMLS via Orphanet