MCID: ALC010
MIFTS: 48

Alcoholic Cardiomyopathy malady

Cardiovascular diseases category
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Summaries for Alcoholic Cardiomyopathy

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65Wikipedia, 33MalaCards
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Wikipedia:65 Alcoholic cardiomyopathy is a disease in which the chronic long-term abuse of alcohol (i.e. ethanol)... more...

MalaCards: Alcoholic Cardiomyopathy, also known as dilated cardiomyopathy secondary to alcohol, is related to hypertension and hypertensive heart disease. An important gene associated with Alcoholic Cardiomyopathy is MSTN (myostatin), and among its related pathways are Regulation of Cholesterol Biosynthesis by SREBP (SREBF) and Adipogenesis. The compounds beta blocking agents and tzd18 have been mentioned in the context of this disorder. Affiliated tissues include heart and liver, and related mouse phenotypes are muscle and adipose tissue.

Aliases & Classifications for Alcoholic Cardiomyopathy

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8Disease Ontology, 62UMLS, 58SNOMED-CT, 35MeSH, 27ICD9CM, 40NCIt, 25ICD10
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Classifications:

Malacards categories (disease lists): (See all malacards categories)
Anatomical: Cardiovascular diseases


Aliases & Descriptions:

alcoholic cardiomyopathy 8
dilated cardiomyopathy secondary to alcohol 8
alcohol-induced heart muscle disease 8
cardiomyopathy, alcoholic 62


External Ids:

Disease Ontology8 DOID:12935
MeSH35 D002310
ICD9CM27 425.5
SNOMED-CT58 155352001, 83521008
NCIt40 C53653
ICD1025 I42.6

Related Diseases for Alcoholic Cardiomyopathy

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17GeneCards, 18GeneDecks
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Diseases related to Alcoholic Cardiomyopathy via text searches within MalaCards or GeneCards/GeneDecks gene sharing:

(show all 42)
idRelated DiseaseScoreTop Affiliating Genes
1hypertension30.2PPARG, PPARA, ACE
2hypertensive heart disease30.1PPARA, ACE
3coronary artery disease29.9PPARA, PPARG, ACE
4retinal artery occlusion10.1APOH
5hypoalphalipoproteinemia10.1PPARA
6sudden cardiac death multi-gene panels10.0ACADM, ACE
7cerebrovascular disease10.0ACE, APOH
8bronchitis10.0PPARA, MSTN
9nephritis10.0ACE, APOH
10hypersplenism10.0
11artery disease10.0
12liver disease10.0
13myocarditis10.0
14myopathy10.0
15hypercholesterolemia10.0ACE, PPARA
16systemic scleroderma10.0ACE, APOH
17proteinuria10.0APOH, ACE
18congenital heart disease10.0PPARA, ACE
19tangier disease10.0PPARA, PPARG
20liposarcoma10.0PPARA, PPARG
21lipodystrophy10.0PPARG, PPARA
22glucose intolerance10.0PPARA, PPARG
23fatty liver disease10.0PPARA, PPARG
24hypertriglyceridemia10.0PPARG, PPARA
25polycystic ovary syndrome10.0PPARA, PPARG
26alzheimer's disease10.0PPARA, PPARG
27noonan syndrome10.0ACADM, ACE
28familial adenomatous polyposis10.0PPARG, PPARA
29idiopathic edema9.9PPARA, PPARG, ACE
30hyperinsulinism9.9PPARA, PPARG
31familial hyperlipidemia9.9PPARA, ACE, PPARG
32diabetic nephropathy9.9ACE, PPARG, PPARA
33obesity9.9MSTN, PPARA, PPARG
34hyperglycemia9.9ACE, PPARA, PPARG
35type 2 diabetes mellitus9.9ACE, PPARA, PPARG
36primary hyperoxaluria9.9PPARA, PPARG, ACE
37diabetes mellitus9.9PPARG, ACE, PPARA
38metabolic syndrome x9.9MSTN, PPARA, PPARG, ACADM
39hypertrophy of breast9.9PPARG, PPARA, MSTN, ACE
40insulin resistance9.9MSTN, ACE, PPARA, PPARG
41vascular disease9.9PPARA, PPARG, APOH, ACE
42atherosclerosis9.9PPARG, PPARA, APOH, ACE

Graphical network of the top 20 diseases related to Alcoholic Cardiomyopathy:



Diseases related to alcoholic cardiomyopathy

Symptoms for Alcoholic Cardiomyopathy

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Drugs & Therapeutics for Alcoholic Cardiomyopathy

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Sources:
42NIH Clinical Center, 6ClinicalTrials
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Drug clinical trials:

Search ClinicalTrials for Alcoholic Cardiomyopathy

Search NIH Clinical Center for Alcoholic Cardiomyopathy

Genetic Tests for Alcoholic Cardiomyopathy

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Anatomical Context for Alcoholic Cardiomyopathy

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33MalaCards
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MalaCards organs/tissues related to Alcoholic Cardiomyopathy:

33
Heart, Liver

Animal Models for Alcoholic Cardiomyopathy or affiliated genes

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37MGI
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MGI Mouse Phenotypes related to Alcoholic Cardiomyopathy:

37
idDescriptionMGI Source AccessionScoreTop Affiliating Genes
1MP:00053698.2PPARA, MSTN, ACADM, PPARG
2MP:00053758.0PPARG, PPARA, MSTN, ACE
3MP:00053707.8PPARG, PPARA, MSTN, ACADM, ACE
4MP:00053857.3PPARG, ACE, ACADM, MSTN, PPARA
5MP:00053767.2ACADM, MSTN, APOH, PPARA, PPARG, ACE
6MP:00107687.1ACE, PPARG, PPARA, APOH, MSTN, ACADM

Publications for Alcoholic Cardiomyopathy

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52PubMed
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Articles related to Alcoholic Cardiomyopathy:

(show top 50)    (show all 130)
idTitleAuthorsYear
1
Alcoholic cardiomyopathy. (24155001)
2013
2
Alcoholic cardiomyopathy and cardiovascular events - an insight from the Liptov region. (23731046)
2013
3
Sensitization to cross-reactive carbohydrate determinants in 2 patients with Hymenoptera venom allergy and alcoholic cardiomyopathy. (22901863)
2012
4
Alcoholic cardiomyopathy: a review. (21962423)
2011
5
Increased myostatin activity and decreased myocyte proliferation in chronic alcoholic cardiomyopathy. (21463333)
2011
6
Functional proteomic analysis reveals sex-dependent differences in structural and energy-producing myocardial proteins in rat model of alcoholic cardiomyopathy. (21245415)
2011
7
Carnitine regulates myocardial metabolism by Peroxisome Proliferator-Activated Receptor-alpha (PPARalpha) in alcoholic cardiomyopathy. (21169901)
2011
8
Tenascin-x facilitates myocardial fibrosis and cardiac remodeling through transforming growth factor-I^1 and peroxisome proliferator-activated receptor I^ in alcoholic cardiomyopathy. (21362339)
2011
9
Evaluation of myocyte proliferation in alcoholic cardiomyopathy: telomerase enzyme activity (TERT) compared with Ki-67 expression. (21733836)
2011
10
With computed tomography confirmed anterolateral left ventricular pseudoaneurysm in patient with dilatative alcoholic cardiomyopathy. (22933953)
2011
11
Anticardiolipin antibodies associated with alcoholic cardiomyopathy. (18666184)
2009
12
Alcoholic cardiomyopathy: acetaldehyde, insulin insensitization and ER stress. (18479704)
2008
13
L-carnitine and cardiac metabolism and remodeling indices in alcoholic cardiomyopathy]. (19080238)
2008
14
Angiotensin II type 1 receptor blockade prevents alcoholic cardiomyopathy. (16831986)
2006
15
Scintigraphic evaluation of cardiac metabolism and sympathetic nerve function in alcoholic cardiomyopathy. (16679703)
2006
16
Ethanol and acetaldehyde in alcoholic cardiomyopathy: from bad to ugly en route to oxidative stress. (15282111)
2004
17
Experimental Assessment of the Role of Acetaldehyde in Alcoholic Cardiomyopathy. (12734561)
2003
18
Gender differences in alcoholic cardiomyopathy. (11859686)
2002
19
A transgenic model of acetaldehyde overproduction accelerates alcohol cardiomyopathy. (10525098)
1999
20
Alcoholic cardiomyopathy: is outcome linked to stimulus withdrawal? (8732367)
1996
21
Alcoholic cardiomyopathy in rats: inotropic responses to phenylephrine, glucagon, ouabain, and dobutamine. (3437459)
1987
22
Alcoholic cardiomyopathy and sudden cardiac death. (3711541)
1986
23
Effect of chronic ethanol ingestion on the metabolism of copper, iron, manganese, selenium, and zinc in an animal model of alcoholic cardiomyopathy. (6502742)
1984
24
Improvement of left ventricular function in alcoholic cardiomyopathy documented by serial gated cardiac pool scanning. (292382)
1979
25
Pulsus alternans induced by glyceryl trinitrate paste in a patient with alcoholic cardiomyopathy. (154916)
1979
26
Alcoholic cardiomyopathy. (884942)
1977
27
Alcoholic cardiomyopathy. (890189)
1977
28
The small coronary arteries in alcoholic cardiomyopathy. (910681)
1977
29
Alcohol and the heart: alcoholic cardiomyopathy. (926061)
1977
30
Alcoholic cardiomyopathy: a nursing approach. (243794)
1977
31
Alcoholic cardiomyopathy in mice. Myocardial glycogen, lipids and certain enzymes. (17013)
1977
32
Reversibility of alcoholic cardiomyopathy. II. Role of atrial fibrillation. (983967)
1976
33
Alcoholic cardiomyopathy: the effect of ethanol and acetaldehyde on cardiac protein synthesis. (1241620)
1975
34
Editorial: Alcoholic cardiomyopathy. (4441876)
1974
35
The incidence of myocardial abnormalities in man related to the level of ethanol consumption. A proposal of a diagnostic criterion of alcoholic cardiomyopathy. (4140250)
1974
36
Letter: Alcoholic cardiomyopathy. (4277554)
1974
37
Alcoholic cardiomyopathy. II. The inhibition of cardiac microsomal protein synthesis by acetaldehyde. (4828692)
1974
38
Heart block in alcoholic cardiomyopathy. (4413642)
1974
39
Alcoholic cardiomyopathy: an introductory review. (4550483)
1972
40
Alcoholic cardiomyopathy. (4944526)
1971
41
Alcoholic cardiomyopathy managed with prolonged bed rest. (4254303)
1971
42
Alcoholic cardiomyopathy. Concept of the disease and its treatment. (4925694)
1971
43
Alcoholic cardiomyopathy: a critical review. (4921395)
1970
44
Alcoholic cardiomyopathy. (5706476)
1968
45
Alcoholic cardiomyopathy. (4166114)
1967
46
Alcoholic cardiomyopathy. (6051265)
1967
47
ALCOHOLIC CARDIOMYOPATHY; A HISTOCHEMICAL STUDY. (14296641)
1965
48
ALCOHOLIC CARDIOMYOPATHY. (14317452)
1965
49
Alcoholic cardiomyopathy. (14447338)
1961
50
Alcoholic cardiomyopathy in a man with Gaustad's syndrome. (13586663)
1958

Variations for Alcoholic Cardiomyopathy

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Expression for genes affiliated with Alcoholic Cardiomyopathy

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Sources:
2BioGPS, 15Gene Expression Omnibus DataSets
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Expression patterns in normal tissues for genes affiliated with Alcoholic Cardiomyopathy

Search GEO for disease gene expression data for Alcoholic Cardiomyopathy.

Pathways for genes affiliated with Alcoholic Cardiomyopathy

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Sources:
50PathCards, 55Reactome, 38NCBI BioSystems Database, 30KEGG
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Compounds for genes affiliated with Alcoholic Cardiomyopathy

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Sources:
51PharmGKB, 29IUPHAR, 45Novoseek, 61Tocris Bioscience, 11DrugBank, 24HMDB
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Compounds related to Alcoholic Cardiomyopathy according to GeneCards/GeneDecks:

(show top 50)    (show all 118)
idCompoundScoreTop Affiliating Genes
1beta blocking agents519.7ACE, PPARA
2tzd18299.5PPARG, PPARA
3gw409544299.5PPARA, PPARG
4mk-0767299.5PPARA, PPARG
5gi262570459.5PPARG, PPARA
6ragaglitazar45 2910.5PPARA, PPARG
7gw 1929459.5PPARA, PPARG
8mono(2-ethylhexyl)phthalate459.5PPARA, PPARG
9ly-510929299.5PPARA, PPARG
10ad-5061299.4PPARG, PPARA
11reglitazar299.4PPARG, PPARA
12farglitazar299.4PPARG, PPARA
13ly-465608299.4PPARG, PPARA
14bisphenol a diglycidyl ether459.4PPARG, PPARA
15tetradecylthioacetic acid459.4PPARG, PPARA
16gw 764745 6110.4PPARA, PPARG
17gw9578299.4PPARA, PPARG
18gw50151645 2910.4PPARA, PPARG
19prostaglandin j2459.4PPARA, PPARG
20tesaglitazar459.4PPARG, PPARA
21octanoate459.0ACADM, PPARA, PPARG
22telmisartan45 29 1111.0PPARA, PPARG, ACE
23carnitine458.9PPARA, PPARG, ACADM
24Lauroyl-CoA248.9PPARA, ACADM, PPARG
25Isovaleryl-CoA248.9PPARG, PPARA, ACADM
26metformin45 51 1110.9ACE, PPARA, PPARG
27Isobutyryl-CoA248.9PPARG, PPARA, ACADM
28Glutaconyl-CoA248.9PPARA, PPARG, ACADM
29Hexanoyl-CoA248.9ACADM, PPARA, PPARG
30Nonanoyl-CoA248.9ACADM, PPARA, PPARG
31Undecanoyl-CoA248.9PPARA, ACADM, PPARG
32pravastatin45 51 29 24 1112.9ACE, PPARA, PPARG
33trans-Octadec-2-enoyl-CoA248.8PPARG, ACADM, PPARA
34Tetracosanoyl-CoA248.8PPARG, PPARA, ACADM
35Pentanoyl-CoA248.8PPARG, PPARA, ACADM
362-Methylhexanoyl-CoA248.8ACADM, PPARG, PPARA
372-methylbutyryl-coa45 249.8ACADM, PPARA, PPARG
38Butyryl-CoA248.8ACADM, PPARA, PPARG
39Decanoyl-CoA (n-C10:0CoA)248.7ACADM, PPARA, PPARG
40octanoyl-coa45 249.7ACADM, PPARA, PPARG
41Eicosanoyl-CoA248.6PPARG, PPARA, ACADM
423Z-dodecenoyl-CoA248.6ACADM, PPARG, PPARA
43(2E)-Dodecenoyl-CoA248.6ACADM, PPARA, PPARG
44(2E)-Octenoyl-CoA248.5ACADM, PPARA, PPARG
45prostacyclin458.4PPARG, APOH, PPARA, ACE
46aspirin45 51 29 2411.4PPARA, ACE, APOH, PPARG
47fatty acid458.4ACADM, APOH, PPARA, PPARG
48(2E)-Decenoyl-CoA248.3ACADM, PPARA, PPARG
49lipid457.9APOH, PPARA, ACADM, PPARG, ACE
50glucose457.6MSTN, APOH, PPARG, ACADM, ACE, PPARA

GO Terms for genes affiliated with Alcoholic Cardiomyopathy

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16Gene Ontology
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Biological processes related to Alcoholic Cardiomyopathy according to GeneCards/GeneDecks:

(show all 10)
idNameGO IDScoreTop Affiliating Genes
1response to coldGO:0094099.3PPARG, ACADM
2negative regulation of receptor biosynthetic processGO:0108719.3PPARA, PPARG
3response to estrogenGO:0436279.2MSTN, PPARG
4positive regulation of fatty acid oxidationGO:0463219.2PPARG, PPARA
5negative regulation of sequestering of triglycerideGO:0108919.2PPARG, PPARA
6negative regulation of cholesterol storageGO:0108879.2PPARA, PPARG
7negative regulation of macrophage derived foam cell differentiationGO:0107459.1PPARA, PPARG
8regulation of blood pressureGO:0082179.0ACE, PPARG
9lipid metabolic processGO:0066299.0PPARA, PPARG
10positive regulation of transcription, DNA-templatedGO:0458938.3PPARG, PPARA, MSTN

Molecular functions related to Alcoholic Cardiomyopathy according to GeneCards/GeneDecks:

idNameGO IDScoreTop Affiliating Genes
1heparin bindingGO:0082019.5APOH, MSTN
2ligand-activated sequence-specific DNA binding RNA polymerase II transcription factor activityGO:0048799.1PPARA, PPARG
3lipid bindingGO:0082899.0APOH, PPARA
4steroid hormone receptor activityGO:0037079.0PPARA, PPARG
5identical protein bindingGO:0428029.0MSTN, ACADM, APOH
6drug bindingGO:0081448.6ACE, PPARA, PPARG

Products for genes affiliated with Alcoholic Cardiomyopathy

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  • Antibodies
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Sources for Alcoholic Cardiomyopathy

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4CDC
13ExPASy
14FMA
22GTR
23HGMD
24HMDB
25ICD10
26ICD10 via Orphanet
27ICD9CM
29IUPHAR
30KEGG
35MeSH
36MESH via Orphanet
37MGI
40NCIt
41NDF-RT
44NINDS
45Novoseek
47OMIM
48OMIM via Orphanet
52PubMed
53QIAGEN
59SNOMED-CT via Orphanet
62UMLS
63UMLS via Orphanet