MCID: ALC010
MIFTS: 43

Alcoholic Cardiomyopathy malady

Category: Cardiovascular diseases

Aliases & Classifications for Alcoholic Cardiomyopathy

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Aliases & Descriptions for Alcoholic Cardiomyopathy:

Name: Alcoholic Cardiomyopathy 10 12
Cardiomyopathy, Alcoholic 36 65
 
Dilated Cardiomyopathy Secondary to Alcohol 10
Alcohol-Induced Heart Muscle Disease 10

Classifications:



External Ids:

Disease Ontology10 DOID:12935
ICD1027 I42.6
ICD9CM29 425.5
SNOMED-CT59 155352001, 83521008
MeSH36 D002310
NCIt42 C53653
UMLS65 C0007192

Summaries for Alcoholic Cardiomyopathy

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Wikipedia:68 Alcoholic cardiomyopathy is a disease in which the chronic long-term abuse of alcohol (i.e. ethanol)... more...

MalaCards based summary: Alcoholic Cardiomyopathy, also known as cardiomyopathy, alcoholic, is related to cardiomyopathy and autoimmune oophoritis. An important gene associated with Alcoholic Cardiomyopathy is PPARA (Peroxisome Proliferator Activated Receptor Alpha), and among its related pathways are Nuclear receptors in lipid metabolism and toxicity and Histidine metabolism. Affiliated tissues include heart, liver and prostate, and related mouse phenotypes are adipose tissue and liver/biliary system.

Related Diseases for Alcoholic Cardiomyopathy

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Graphical network of the top 20 diseases related to Alcoholic Cardiomyopathy:



Diseases related to alcoholic cardiomyopathy

Symptoms for Alcoholic Cardiomyopathy

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Drugs & Therapeutics for Alcoholic Cardiomyopathy

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Drugs for Alcoholic Cardiomyopathy (from DrugBank, HMDB, Dgidb, PharmGKB, IUPHAR, NovoSeek, BitterDB):

(show all 11)
idNameStatusPhaseClinical TrialsCas NumberPubChem Id
1
SpironolactoneapprovedPhase 41591952-01-7, 52-01-75833
Synonyms:
4-18-00-01601 (Beilstein Handbook Reference)
4-Pregnen-21-oic acid-17alpha-ol-3-one-7alpha-thiol gamma-lactone 7-acetate
496916-40-6
52-01-7
7-alpha-Acetylthio-3-oxo-17-alpha-pregn-4-ene-21,17-beta-carbolactone
7alpha-(acetylsulfanyl)-3-oxo-17alpha-pregn-4-ene-21,17-carbolactone
AB00513806
AC-4214
AC1L1L8Q
Abbolactone
Acelat
Aldace
Aldactazide
Aldactide
Aldactone
Aldactone (TN)
Aldactone A
Alderon
Aldopur
Almatol
Alphapharm Brand of Spironolactone
Alpharma Brand of Spironolactone
Alter Brand of Spironolactone
Altex
Aquareduct
Ashbourne Brand of Spironolactone
Azupharma Brand of Spironolactone
BIDD:PXR0071
BPBio1_000194
BRD-K90027355-001-03-4
BRN 0057767
BSPBio_000176
C07310
C24H32O4S
CHEBI:428201
CHEBI:45692
CHEBI:9241
CHEMBL1393
CID5833
CPD000471892
Cardel Brand of Spironolactone
D00443
D013148
DB00421
Deverol
Dexo Brand of Spironolactone
Diatensec
Dira
Duraspiron
EINECS 200-133-6
Espironolactona
Espironolactona Alter
Espironolactona Mundogen
Espironolactona [INN-Spanish]
Euteberol
Flumach
Frumikal
Generosan Brand of Spironolactone
HMS1568I18
HMS2090N21
HSDB 3184
Hormosan Brand of Spironolactone
I06-1970
Jenapharm Brand of Spironolactone
Jenaspiron
LS-118614
LT00772287
Lacalmin
Lacdene
Laractone
MLS001074672
MLS001333253
MLS001333254
MLS002153245
MLS002207058
Mayoly-Spindler Brand of Spironolactone
Melarcon
Merck dura Brand of Spironolactone
Mundogen Brand of Spironolactone
NCGC00164397-01
 
NCGC00164397-02
NSC 150399
NSC150399
Nefurofan
Novo Spiroton
Novo-Spiroton
NovoSpiroton
Novopharm Brand of Spironolactone
Osyrol
Pfizer Brand of Spironolactone
Pharmafrid Brand of Spironolactone
Practon
Prestwick0_000128
Prestwick1_000128
Prestwick2_000128
Prestwick3_000128
Roche Brand of Spironolactone
S0260
S3378_SIGMA
SAM002264648
SC 9420
SC-9420
SC9420
SMR000471892
SNL
SPBio_002115
Sagisal
Searle Brand of Spironolactone
Sincomen
Spiractin
Spiresis
Spiretic
Spiridon
Spiro L.U.T.
Spiro(17H-cyclopenta(a)phenauthrene-17,2'-(3'H)-furan)
Spiro-Tablinen
Spiro[17H-cyclopenta[a]phenauthrene-17,2'-(3'H)-furan]
Spirobeta
Spiroctan
Spiroctanie
Spiroderm
Spirogamma
Spirolactone
Spirolakton
Spirolang
Spirolone
Spirone
Spirono Isis
Spirono-Isis
Spironocompren
Spironolactone
Spironolactone (JP15/USP/INN)
Spironolactone A
Spironolactone [BAN:INN:JAN]
Spironolactone [INN:BAN:JAN]
Spironolactonum
Spironolactonum [INN-Latin]
Spironolattone
Spironolattone [DCIT]
Spironone
Spirospare
Sprioderm
Supra-puren
Suracton
UNII-27O7W4T232
Uractone
Urusonin
Veroshpiron
Verospiron
Verospirone
Verospirone Opianin
WLN: L E5 B666 FX OV MUTJ A1 E1 KSV1 F-& CT5VOXTJ
Worwag Brand of Spironolactone
Xenalon
ZINC03861599
betapharm Brand of Spironolactone
ct Arzneimittel Brand of Spironolactone
ct-Arzneimittel Brand of Spironolactone
spiro von ct
spironolactone
spironolattone
von ct, spiro
2MineralocorticoidsPhase 4301
3Natriuretic AgentsPhase 41403
4diureticsPhase 41194
5Mineralocorticoid Receptor AntagonistsPhase 4284
6Diuretics, Potassium SparingPhase 41445
7Hormones, Hormone Substitutes, and Hormone AntagonistsPhase 49988
8Hormone AntagonistsPhase 410002
9HormonesPhase 411748
10Antioxidants2442
11Liver Extracts3572

Interventional clinical trials:

idNameStatusNCT IDPhase
1Clinical Trial Studying the Effects of Spironolactone on Heart and Skeletal Muscle Function in Chronic AlcoholicsSuspendedNCT00226109Phase 4
2Subclinical Myocardial Dysfunction in Patients With Hepatic CirrhosisCompletedNCT01713478
3Prospective Analysis Of Cardiac Function In Cirrhotic Patients By Echocardiography And Its Correlation With EventsEnrolling by invitationNCT01433848
4Adapted Physical Activity Effect on Aerobic Function and in Patients in Pre Liver TransplantationNot yet recruitingNCT02567591

Search NIH Clinical Center for Alcoholic Cardiomyopathy


Cochrane evidence based reviews: cardiomyopathy, alcoholic

Genetic Tests for Alcoholic Cardiomyopathy

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Anatomical Context for Alcoholic Cardiomyopathy

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MalaCards organs/tissues related to Alcoholic Cardiomyopathy:

33
Heart, Liver, Prostate, Thyroid, Breast, Endothelial, B cells

Animal Models for Alcoholic Cardiomyopathy or affiliated genes

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MGI Mouse Phenotypes related to Alcoholic Cardiomyopathy:

38
idDescriptionMGI Source AccessionScoreTop Affiliating Genes
1MP:00053759.1ACE, MSTN, PPARA, PPARG
2MP:00053708.8ACADM, ACE, MSTN, PPARA, PPARG
3MP:00020068.7ACE, ALDH2, PPARG, TNXB
4MP:00053858.0ACADM, ACE, MSTN, PPARA, PPARG, RGS6
5MP:00107686.9ACADM, ACE, ALDH2, MSTN, PPARA, PPARG

Publications for Alcoholic Cardiomyopathy

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Articles related to Alcoholic Cardiomyopathy:

(show top 50)    (show all 140)
idTitleAuthorsYear
1
Malignant ventricular arrhythmias in alcoholic cardiomyopathy. (26188828)
2015
2
Investigation of microRNA Expression Profiles Associated with Human Alcoholic Cardiomyopathy. (25791397)
2015
3
Alcoholic cardiomyopathy. (24155001)
2013
4
Alcoholic cardiomyopathy and cardiovascular events - an insight from the Liptov region. (23731046)
2013
5
Sensitization to cross-reactive carbohydrate determinants in 2 patients with Hymenoptera venom allergy and alcoholic cardiomyopathy. (22901863)
2012
6
Alcoholic cardiomyopathy: a review. (21962423)
2011
7
Increased myostatin activity and decreased myocyte proliferation in chronic alcoholic cardiomyopathy. (21463333)
2011
8
Functional proteomic analysis reveals sex-dependent differences in structural and energy-producing myocardial proteins in rat model of alcoholic cardiomyopathy. (21245415)
2011
9
Carnitine regulates myocardial metabolism by Peroxisome Proliferator-Activated Receptor-alpha (PPARalpha) in alcoholic cardiomyopathy. (21169901)
2011
10
Tenascin-x facilitates myocardial fibrosis and cardiac remodeling through transforming growth factor-I^1 and peroxisome proliferator-activated receptor I^ in alcoholic cardiomyopathy. (21362339)
2011
11
Evaluation of myocyte proliferation in alcoholic cardiomyopathy: telomerase enzyme activity (TERT) compared with Ki-67 expression. (21733836)
2011
12
With computed tomography confirmed anterolateral left ventricular pseudoaneurysm in patient with dilatative alcoholic cardiomyopathy. (22933953)
2011
13
Anticardiolipin antibodies associated with alcoholic cardiomyopathy. (18666184)
2009
14
Alcoholic cardiomyopathy: acetaldehyde, insulin insensitization and ER stress. (18479704)
2008
15
L-carnitine and cardiac metabolism and remodeling indices in alcoholic cardiomyopathy]. (19080238)
2008
16
Angiotensin II type 1 receptor blockade prevents alcoholic cardiomyopathy. (16831986)
2006
17
Scintigraphic evaluation of cardiac metabolism and sympathetic nerve function in alcoholic cardiomyopathy. (16679703)
2006
18
Ethanol and acetaldehyde in alcoholic cardiomyopathy: from bad to ugly en route to oxidative stress. (15282111)
2004
19
Gender differences in alcoholic cardiomyopathy. (11859686)
2002
20
A transgenic model of acetaldehyde overproduction accelerates alcohol cardiomyopathy. (10525098)
1999
21
Alcoholic cardiomyopathy: is outcome linked to stimulus withdrawal? (8732367)
1996
22
Alcoholic cardiomyopathy in rats: inotropic responses to phenylephrine, glucagon, ouabain, and dobutamine. (3437459)
1987
23
Alcoholic cardiomyopathy and sudden cardiac death. (3711541)
1986
24
Effect of chronic ethanol ingestion on the metabolism of copper, iron, manganese, selenium, and zinc in an animal model of alcoholic cardiomyopathy. (6502742)
1984
25
Improvement of left ventricular function in alcoholic cardiomyopathy documented by serial gated cardiac pool scanning. (292382)
1979
26
Alcoholic cardiomyopathy. (884942)
1977
27
Alcoholic cardiomyopathy. (890189)
1977
28
The small coronary arteries in alcoholic cardiomyopathy. (910681)
1977
29
Alcohol and the heart: alcoholic cardiomyopathy. (926061)
1977
30
Alcoholic cardiomyopathy: a nursing approach. (243794)
1977
31
Alcoholic cardiomyopathy in mice. Myocardial glycogen, lipids and certain enzymes. (17013)
1977
32
Reversibility of alcoholic cardiomyopathy. II. Role of atrial fibrillation. (983967)
1976
33
Alcoholic cardiomyopathy: the effect of ethanol and acetaldehyde on cardiac protein synthesis. (1241620)
1975
34
Editorial: Alcoholic cardiomyopathy. (4441876)
1974
35
The incidence of myocardial abnormalities in man related to the level of ethanol consumption. A proposal of a diagnostic criterion of alcoholic cardiomyopathy. (4140250)
1974
36
Letter: Alcoholic cardiomyopathy. (4277554)
1974
37
Alcoholic cardiomyopathy. II. The inhibition of cardiac microsomal protein synthesis by acetaldehyde. (4828692)
1974
38
Heart block in alcoholic cardiomyopathy. (4413642)
1974
39
Alcoholic cardiomyopathy: an introductory review. (4550483)
1972
40
Alcoholic cardiomyopathy. (4944526)
1971
41
Alcoholic cardiomyopathy managed with prolonged bed rest. (4254303)
1971
42
Alcoholic cardiomyopathy. Concept of the disease and its treatment. (4925694)
1971
43
Alcoholic cardiomyopathy: a critical review. (4921395)
1970
44
Alcoholic cardiomyopathy. (5706476)
1968
45
Alcoholic cardiomyopathy. (4166114)
1967
46
Alcoholic cardiomyopathy. (6051265)
1967
47
ALCOHOLIC CARDIOMYOPATHY; A HISTOCHEMICAL STUDY. (14296641)
1965
48
ALCOHOLIC CARDIOMYOPATHY. (14317452)
1965
49
Alcoholic cardiomyopathy. (14447338)
1961
50
Alcoholic cardiomyopathy in a man with Gaustad's syndrome. (13586663)
1958

Variations for Alcoholic Cardiomyopathy

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Expression for genes affiliated with Alcoholic Cardiomyopathy

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Search GEO for disease gene expression data for Alcoholic Cardiomyopathy.

Pathways for genes affiliated with Alcoholic Cardiomyopathy

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Pathways related to Alcoholic Cardiomyopathy according to GeneCards Suite gene sharing:

(show all 12)
idSuper pathwaysScoreTop Affiliating Genes
19.8PPARA, PPARG
2
Show member pathways
9.3ALDH2, ALDH3A2
39.3ALDH2, ALDH3A2
4
Show member pathways
9.3ALDH2, ALDH3A2
5
Show member pathways
9.3ALDH2, ALDH3A2
6
Show member pathways
9.3ALDH2, ALDH3A2
7
Show member pathways
9.3ALDH2, ALDH3A2
89.3ALDH2, ALDH3A2
9
Show member pathways
9.3ACADM, PPARA, PPARG
10
Show member pathways
8.9ACADM, ALDH2, ALDH3A2
11
Show member pathways
8.9ACADM, ALDH2, ALDH3A2
12
Show member pathways
8.9ACADM, ALDH2, ALDH3A2

GO Terms for genes affiliated with Alcoholic Cardiomyopathy

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Biological processes related to Alcoholic Cardiomyopathy according to GeneCards Suite gene sharing:

(show all 8)
idNameGO IDScoreTop Affiliating Genes
1positive regulation of fatty acid oxidationGO:004632110.4PPARA, PPARG
2negative regulation of cholesterol storageGO:001088710.4PPARA, PPARG
3negative regulation of receptor biosynthetic processGO:001087110.2PPARA, PPARG
4response to coldGO:000940910.1ACADM, PPARG
5regulation of circadian rhythmGO:004275210.0PPARA, PPARG
6response to starvationGO:00425949.8ACADM, PPARG
7heart developmentGO:00075079.3ACADM, PPARA, PPARG
8positive regulation of transcription, DNA-templatedGO:00458939.3MSTN, PPARA, PPARG

Molecular functions related to Alcoholic Cardiomyopathy according to GeneCards Suite gene sharing:

idNameGO IDScoreTop Affiliating Genes
1drug bindingGO:00081449.8PPARA, PPARG
2aldehyde dehydrogenase [NAD(P)+] activityGO:00040309.4ALDH2, ALDH3A2

Sources for Alcoholic Cardiomyopathy

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2CDC
14ExPASy
15FDA
16FMA
24GTR
25HGMD
26HMDB
27ICD10
28ICD10 via Orphanet
29ICD9CM
30IUPHAR
31KEGG
34MedGen
36MeSH
37MESH via Orphanet
38MGI
41NCI
42NCIt
43NDF-RT
46NINDS
47Novoseek
49OMIM
50OMIM via Orphanet
54PubMed
55QIAGEN
60SNOMED-CT via Orphanet
64Tumor Gene Family of Databases
65UMLS
66UMLS via Orphanet