MCID: ALC010
MIFTS: 39

Alcoholic Cardiomyopathy malady

Category: Cardiovascular diseases

Aliases & Classifications for Alcoholic Cardiomyopathy

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Aliases & Descriptions for Alcoholic Cardiomyopathy:

Name: Alcoholic Cardiomyopathy 10 12
Cardiomyopathy, Alcoholic 36 65
 
Dilated Cardiomyopathy Secondary to Alcohol 10
Alcohol-Induced Heart Muscle Disease 10

Classifications:



External Ids:

Disease Ontology10 DOID:12935
ICD1027 I42.6
ICD9CM29 425.5
SNOMED-CT59 155352001, 83521008
MeSH36 D002310
NCIt42 C53653
UMLS65 C0007192

Summaries for Alcoholic Cardiomyopathy

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Wikipedia:68 Alcoholic cardiomyopathy is a disease in which the chronic long-term abuse of alcohol (i.e. ethanol)... more...

MalaCards based summary: Alcoholic Cardiomyopathy, also known as cardiomyopathy, alcoholic, is related to candidiasis and autoimmune oophoritis. An important gene associated with Alcoholic Cardiomyopathy is PPARA (Peroxisome Proliferator Activated Receptor Alpha), and among its related pathways are Nuclear receptors in lipid metabolism and toxicity and Histidine metabolism. Affiliated tissues include heart, liver and skeletal muscle, and related mouse phenotypes are adipose tissue and liver/biliary system.

Related Diseases for Alcoholic Cardiomyopathy

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Diseases related to Alcoholic Cardiomyopathy via text searches within MalaCards or GeneCards Suite gene sharing:

(show top 50)    (show all 127)
idRelated DiseaseScoreTop Affiliating Genes
1candidiasis29.6ALDH2, ALDH3A2
2autoimmune oophoritis10.2PPARA, PPARG
3casp10-related autoimmune lymphoproliferative syndrome10.2ACE, PPARA
4idiopathic hypersomnia10.1ACE, PPARA, PPARG
5fbxl4-related mitochondrial dna depletion syndrome, encephalomyopathic form10.1ACADM, PPARA
6hyperglycemia10.1ACE, PPARA, PPARG
7dermal unilateral segmental cavernous angioma10.0ACE, PPARA, PPARG
8organic acidemia10.0ACE, PPARA, PPARG
9colorectal cancer10.0
10colonic benign neoplasm10.0ACE, PPARA, PPARG
11ochronosis9.9ACADM, PPARA, PPARG
12rheumatoid arthritis9.9
13renal cell carcinoma9.9
14arthritis9.9
15glomerulonephritis9.9
16prostatitis9.9
17laryngitis9.9
18thyroiditis9.9
19hypoxia9.9
20heart lymphoma9.9PPARA, PPARG
21primary non-gestational choriocarcinoma of ovary9.9ACE, TNXB
22neural tube defects9.8
23atopy9.8
24prostate cancer9.8
25breast cancer9.8
26obesity9.8
27lymphangioleiomyomatosis9.8
28machado-joseph disease9.8
29prader-willi syndrome9.8
30gilles de la tourette syndrome9.8
31insulin-like growth factor i9.8
32pancreatic cancer9.8
33lipoma9.8
34tendinopathy9.8
35deficiency anemia9.8
36amelogenesis imperfecta9.8
37b-cell lymphomas9.8
38burn scar9.8
39burns9.8
40keloids9.8
41leukemia9.8
42liver disease9.8
43mantle cell lymphoma9.8
44marginal zone b-cell lymphoma9.8
45arrhythmogenic right ventricular cardiomyopathy9.8
46zollinger-ellison syndrome9.8
47sleep apnea9.8
48lymphoma9.8
49stuttering9.8
50neuroretinitis9.8

Graphical network of the top 20 diseases related to Alcoholic Cardiomyopathy:



Diseases related to alcoholic cardiomyopathy

Symptoms for Alcoholic Cardiomyopathy

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Drugs & Therapeutics for Alcoholic Cardiomyopathy

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Drugs for Alcoholic Cardiomyopathy (from DrugBank, HMDB, Dgidb, PharmGKB, IUPHAR, NovoSeek, BitterDB):

(show all 11)
idNameStatusPhaseClinical TrialsCas NumberPubChem Id
1
SpironolactoneapprovedPhase 41591952-01-7, 52-01-75833
Synonyms:
4-18-00-01601 (Beilstein Handbook Reference)
4-Pregnen-21-oic acid-17alpha-ol-3-one-7alpha-thiol gamma-lactone 7-acetate
496916-40-6
52-01-7
7-alpha-Acetylthio-3-oxo-17-alpha-pregn-4-ene-21,17-beta-carbolactone
7alpha-(acetylsulfanyl)-3-oxo-17alpha-pregn-4-ene-21,17-carbolactone
AB00513806
AC-4214
AC1L1L8Q
Abbolactone
Acelat
Aldace
Aldactazide
Aldactide
Aldactone
Aldactone (TN)
Aldactone A
Alderon
Aldopur
Almatol
Alphapharm Brand of Spironolactone
Alpharma Brand of Spironolactone
Alter Brand of Spironolactone
Altex
Aquareduct
Ashbourne Brand of Spironolactone
Azupharma Brand of Spironolactone
BIDD:PXR0071
BPBio1_000194
BRD-K90027355-001-03-4
BRN 0057767
BSPBio_000176
C07310
C24H32O4S
CHEBI:428201
CHEBI:45692
CHEBI:9241
CHEMBL1393
CID5833
CPD000471892
Cardel Brand of Spironolactone
D00443
D013148
DB00421
Deverol
Dexo Brand of Spironolactone
Diatensec
Dira
Duraspiron
EINECS 200-133-6
Espironolactona
Espironolactona Alter
Espironolactona Mundogen
Espironolactona [INN-Spanish]
Euteberol
Flumach
Frumikal
Generosan Brand of Spironolactone
HMS1568I18
HMS2090N21
HSDB 3184
Hormosan Brand of Spironolactone
I06-1970
Jenapharm Brand of Spironolactone
Jenaspiron
LS-118614
LT00772287
Lacalmin
Lacdene
Laractone
MLS001074672
MLS001333253
MLS001333254
MLS002153245
MLS002207058
Mayoly-Spindler Brand of Spironolactone
Melarcon
Merck dura Brand of Spironolactone
Mundogen Brand of Spironolactone
NCGC00164397-01
 
NCGC00164397-02
NSC 150399
NSC150399
Nefurofan
Novo Spiroton
Novo-Spiroton
NovoSpiroton
Novopharm Brand of Spironolactone
Osyrol
Pfizer Brand of Spironolactone
Pharmafrid Brand of Spironolactone
Practon
Prestwick0_000128
Prestwick1_000128
Prestwick2_000128
Prestwick3_000128
Roche Brand of Spironolactone
S0260
S3378_SIGMA
SAM002264648
SC 9420
SC-9420
SC9420
SMR000471892
SNL
SPBio_002115
Sagisal
Searle Brand of Spironolactone
Sincomen
Spiractin
Spiresis
Spiretic
Spiridon
Spiro L.U.T.
Spiro(17H-cyclopenta(a)phenauthrene-17,2'-(3'H)-furan)
Spiro-Tablinen
Spiro[17H-cyclopenta[a]phenauthrene-17,2'-(3'H)-furan]
Spirobeta
Spiroctan
Spiroctanie
Spiroderm
Spirogamma
Spirolactone
Spirolakton
Spirolang
Spirolone
Spirone
Spirono Isis
Spirono-Isis
Spironocompren
Spironolactone
Spironolactone (JP15/USP/INN)
Spironolactone A
Spironolactone [BAN:INN:JAN]
Spironolactone [INN:BAN:JAN]
Spironolactonum
Spironolactonum [INN-Latin]
Spironolattone
Spironolattone [DCIT]
Spironone
Spirospare
Sprioderm
Supra-puren
Suracton
UNII-27O7W4T232
Uractone
Urusonin
Veroshpiron
Verospiron
Verospirone
Verospirone Opianin
WLN: L E5 B666 FX OV MUTJ A1 E1 KSV1 F-& CT5VOXTJ
Worwag Brand of Spironolactone
Xenalon
ZINC03861599
betapharm Brand of Spironolactone
ct Arzneimittel Brand of Spironolactone
ct-Arzneimittel Brand of Spironolactone
spiro von ct
spironolactone
spironolattone
von ct, spiro
2MineralocorticoidsPhase 4301
3Natriuretic AgentsPhase 41403
4diureticsPhase 41194
5Mineralocorticoid Receptor AntagonistsPhase 4284
6Diuretics, Potassium SparingPhase 41445
7Hormones, Hormone Substitutes, and Hormone AntagonistsPhase 49988
8Hormone AntagonistsPhase 410002
9HormonesPhase 411748
10Antioxidants2442
11Liver Extracts3572

Interventional clinical trials:

idNameStatusNCT IDPhase
1Clinical Trial Studying the Effects of Spironolactone on Heart and Skeletal Muscle Function in Chronic AlcoholicsSuspendedNCT00226109Phase 4
2Subclinical Myocardial Dysfunction in Patients With Hepatic CirrhosisCompletedNCT01713478
3Prospective Analysis Of Cardiac Function In Cirrhotic Patients By Echocardiography And Its Correlation With EventsEnrolling by invitationNCT01433848
4Adapted Physical Activity Effect on Aerobic Function and in Patients in Pre Liver TransplantationNot yet recruitingNCT02567591

Search NIH Clinical Center for Alcoholic Cardiomyopathy


Cochrane evidence based reviews: cardiomyopathy, alcoholic

Genetic Tests for Alcoholic Cardiomyopathy

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Anatomical Context for Alcoholic Cardiomyopathy

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MalaCards organs/tissues related to Alcoholic Cardiomyopathy:

33
Heart, Liver, Skeletal muscle, Breast, Endothelial, Prostate, Myeloid

Animal Models for Alcoholic Cardiomyopathy or affiliated genes

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MGI Mouse Phenotypes related to Alcoholic Cardiomyopathy:

38
idDescriptionMGI Source AccessionScoreTop Affiliating Genes
1MP:00053759.1ACE, MSTN, PPARA, PPARG
2MP:00053708.8ACADM, ACE, MSTN, PPARA, PPARG
3MP:00020068.7ACE, ALDH2, PPARG, TNXB
4MP:00053858.0ACADM, ACE, MSTN, PPARA, PPARG, RGS6
5MP:00107686.9ACADM, ACE, ALDH2, MSTN, PPARA, PPARG

Publications for Alcoholic Cardiomyopathy

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Articles related to Alcoholic Cardiomyopathy:

(show top 50)    (show all 139)
idTitleAuthorsYear
1
Clinical presentation and treatment responses in IgM-related AL amyloidosis. (26488936)
2015
2
Erratum: Concordance and limits between transcutaneous and arterial carbon dioxide pressure in emergency department patients with acute respiratory failure: a single-center, prospective, and observational study. (26572985)
2015
3
Autoimmune thyroiditis in children and adolescents with type 1 diabetes mellitus is associated with elevated IgG4 but not with low vitamin D. (25079460)
2014
4
Elevated adiponectin expression promotes adipose tissue vascularity under conditions of diet-induced obesity. (23993424)
2013
5
Nonseminomatous germ cell tumor of testis and interrupted treatment. (24133836)
2013
6
CHD1L is a novel independent prognostic factor for gastric cancer. (24258459)
2013
7
Virulence factors in isolates of Enterococcus faecalis from infective endocarditis and from the normal flora. (23044056)
2013
8
The human topoisomerase 1B Arg634Ala mutation results in camptothecin resistance and loss of inter-domain motion correlation. (24096022)
2013
9
Expression of CAS in hepatocellular carcinoma tissues and its relationship with HBV infection]. (23189846)
2012
10
ADRB3 polymorphism associated with BMI gain in Japanese men. (22550477)
2012
11
Magnetic resonance imaging determined visceral fat reduction associates with enhanced IL-10 plasma levels in calorie restricted obese subjects. (23300769)
2012
12
High Wilms' tumor 1 mRNA expression correlates with basal-like and ERBB2 molecular subtypes and poor prognosis of breast cancer. (22797561)
2012
13
Rare case of septic arthritis caused by Candida krusei: case report and literature review. (22661427)
2012
14
The surgical treatment of lymphedema: a systematic review of the contemporary literature (2004-2010). (21863361)
2012
15
Causes, clinical symptoms, and outcomes of infectious diseases associated with hemophagocytic lymphohistiocytosis in Taiwanese adults. (21524613)
2011
16
Dopamine D4 receptor gene DRD4 and its association with psychiatric disorders. (21873960)
2011
17
Age-at-onset in bipolar-I disorder: mixture analysis of 1369 cases identifies three distinct clinical sub-groups. (19062104)
2009
18
New Findings in PiZZ alpha1-antitrypsin deficiency-related panniculitis. Demonstration of skin polymers and high dosing requirements of intravenous augmentation therapy. (19218787)
2009
19
Epigenetic reprogramming of IGF1 and leptin genes by serum deprivation in multipotential mesenchymal stromal cells. (19038795)
2009
20
Hydrocephalus induced chorea. (21686773)
2009
21
Activation of cytosolic phospholipase A2 in dorsal root ganglion neurons by Ca2+/calmodulin-dependent protein kinase II after peripheral nerve injury. (19409102)
2009
22
Two mutations in LDLR gene were found in two Chinese families with familial hypercholesterolemia. (19020990)
2009
23
GluR3 flip and flop: differences in channel opening kinetics. (17256974)
2007
24
Pharyngeal actinomycosis: a case report. (17518961)
2007
25
Mycobacterium szulgai identification by hsp65 gene sequencing in an HIV-positive patient with non-Hodgkin's lymphoma. (17058790)
2006
26
L-Arginine supplementation or arginase inhibition augments reflex cutaneous vasodilatation in aged human skin. (16675494)
2006
27
The expression of insulin-like growth factor and insulin-like growth factor binding protein mRNAs in mouse placenta. (16338473)
2006
28
The relationship between hepatic expression, serum level of TGFbeta1 and the hepatic fibrosis in patients with viral hepatitis]. (15161500)
2004
29
Enhancing the activity of insulin at the receptor interface: crystal structure and photo-cross-linking of A8 analogues. (15610006)
2004
30
Activated Akt expression has significant correlation with EGFR and TGF-alpha expressions in stage I NSCLC. (15015570)
2004
31
Overview: translating Hsp90 biology into Hsp90 drugs. (14529382)
2003
32
Down-regulation of alpha class glutathione S-transferase by interleukin-1beta in human intestinal epithelial cells (Caco-2) in culture. (12386123)
2002
33
Uncoupling the ATPase activity of the N-ethylmaleimide sensitive factor (NSF) from 20S complex disassembly. (11781091)
2002
34
Expression of claudin-1, a recently described tight junction-associated protein, distinguishes soft tissue perineurioma from potential mimics. (12459629)
2002
35
Purification and structural analysis of a soluble human chorionogonadotropin hormone-receptor complex. (11018026)
2001
36
Synthesis, proton-affinity and anti-cancer properties of the prodigiosin-group natural products. (12678767)
2001
37
Protein kinase C-mediated down-regulation of MDR3 mRNA expression in Chang liver cells. (11331069)
2001
38
Lipoid proteinosis of the oral mucosa: case report and review of the literature. (9894251)
1998
39
Expression of pS2 protein and estrogen and progesterone receptor status in breast cancer. (9167689)
1997
40
Second primary head and neck squamous cell carcinoma predicted by the glutathione S-transferase expression in healthy tissue in the direct vicinity of the first tumor. (7474922)
1995
41
Cutis laxa: etiology, pathophysiology, characteristics, and management. (8710969)
1995
42
Two cases of lateral sinus thrombosis presenting with extracranial head and neck abscesses. (7964144)
1994
43
A single amino acid substitution in the exoplasmic domain of the human growth hormone (GH) receptor confers familial GH resistance (Laron syndrome) with positive GH-binding activity by abolishing receptor homodimerization. (8137822)
1994
44
c-fes expression in ontogenetic development and hematopoietic differentiation. (8108116)
1994
45
Biochemical aspects of the blood group Rh (rhesus) antigens. (8043932)
1993
46
Antitumor effector cells in recombinant IL-2 activated tumor infiltrating lymphocytes from human solid cancers]. (7686244)
1993
47
Isoprenoid modification permits 2',3'-cyclic nucleotide 3'-phosphodiesterase to bind to membranes. (1666129)
1991
48
Myofascial pain syndrome and fibromyalgia. (1947490)
1991
49
Cytomegalovirus infection of adipose tissues induces steatitis in adult mice. (2169300)
1990
50
First metatarsal-cuneiform dorsal exostosis: its anatomical relation with the medial dorsal cutaneous nerve. (2584628)
1989

Variations for Alcoholic Cardiomyopathy

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Expression for genes affiliated with Alcoholic Cardiomyopathy

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Search GEO for disease gene expression data for Alcoholic Cardiomyopathy.

Pathways for genes affiliated with Alcoholic Cardiomyopathy

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Pathways related to Alcoholic Cardiomyopathy according to GeneCards Suite gene sharing:

(show all 12)
idSuper pathwaysScoreTop Affiliating Genes
19.8PPARA, PPARG
2
Show member pathways
9.3ALDH2, ALDH3A2
39.3ALDH2, ALDH3A2
4
Show member pathways
9.3ALDH2, ALDH3A2
5
Show member pathways
9.3ALDH2, ALDH3A2
6
Show member pathways
9.3ALDH2, ALDH3A2
7
Show member pathways
9.3ALDH2, ALDH3A2
89.3ALDH2, ALDH3A2
9
Show member pathways
9.3ACADM, PPARA, PPARG
10
Show member pathways
8.9ACADM, ALDH2, ALDH3A2
11
Show member pathways
8.9ACADM, ALDH2, ALDH3A2
12
Show member pathways
8.9ACADM, ALDH2, ALDH3A2

GO Terms for genes affiliated with Alcoholic Cardiomyopathy

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Biological processes related to Alcoholic Cardiomyopathy according to GeneCards Suite gene sharing:

(show all 8)
idNameGO IDScoreTop Affiliating Genes
1positive regulation of fatty acid oxidationGO:004632110.4PPARA, PPARG
2negative regulation of cholesterol storageGO:001088710.4PPARA, PPARG
3negative regulation of receptor biosynthetic processGO:001087110.2PPARA, PPARG
4response to coldGO:000940910.1ACADM, PPARG
5regulation of circadian rhythmGO:004275210.0PPARA, PPARG
6response to starvationGO:00425949.8ACADM, PPARG
7heart developmentGO:00075079.3ACADM, PPARA, PPARG
8positive regulation of transcription, DNA-templatedGO:00458939.3MSTN, PPARA, PPARG

Molecular functions related to Alcoholic Cardiomyopathy according to GeneCards Suite gene sharing:

idNameGO IDScoreTop Affiliating Genes
1drug bindingGO:00081449.8PPARA, PPARG
2aldehyde dehydrogenase [NAD(P)+] activityGO:00040309.4ALDH2, ALDH3A2

Sources for Alcoholic Cardiomyopathy

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2CDC
14ExPASy
15FDA
16FMA
24GTR
25HGMD
26HMDB
27ICD10
28ICD10 via Orphanet
29ICD9CM
30IUPHAR
31KEGG
34MedGen
36MeSH
37MESH via Orphanet
38MGI
41NCI
42NCIt
43NDF-RT
46NINDS
47Novoseek
49OMIM
50OMIM via Orphanet
54PubMed
55QIAGEN
60SNOMED-CT via Orphanet
64Tumor Gene Family of Databases
65UMLS
66UMLS via Orphanet