Alcoholic Cardiomyopathy malady

Wikipedia: Alcoholic cardiomyopathy is a disease in which the chronic long-term abuse of alcohol (i.e. ethanol)...⁴⁴ more...

MalaCards: Alcoholic Cardiomyopathy, also known as dilated cardiomyopathy secondary to alcohol (disorder), is related to sudden cardiac death multi-gene panels and alcoholic pancreatitis. An important gene associated with Alcoholic Cardiomyopathy is ACADM (acyl-CoA dehydrogenase, C-4 to C-12 straight chain), and among its related pathways are Cyclophosphamide Pathway, Pharmacodynamics and beta-Alanine metabolism. The drugs amrinone and amrinone lactate and the compounds propionaldehyde and benzaldehyde have been mentioned in the context of this disorder. Affiliated tissues include heart, and related mouse phenotypes are mortality/aging and homeostasis/metabolism.

Aliases & Descriptions:

alcoholic cardiomyopathy 6 8 dilated cardiomyopathy secondary to alcohol (disorder) 6 alcohol-induced heart muscle disease 6

cardiomyopathy, alcoholic 43 cardiomyopathy, dilated 43

Diseases related to alcoholic cardiomyopathy by text searches and GeneDecks gene sharing:

(show top 50)    (show all 177)

id	Related Disease	Score	Top Affiliating Genes
1	sudden cardiac death multi-gene panels	28.1	ACADM, ACE
2	alcoholic pancreatitis	13.1	AKR1A1, ALDH2
3	fetal alcohol syndrome	13.1	ALDH2, AKR1A1
4	alcoholic liver cirrhosis	13.1	AKR1A1, ALDH2
5	fatty acid oxidation disorders	13.0	PPARA, ACADM
6	carbohydrate metabolic disorder	12.9	PPARG, PPARA
7	short limb dwarf edema iris coloboma	12.8	PPARG, PPARA
8	central nervous system disease	12.8	PPARG, APOH
9	autoimmune myocarditis	12.7	PPARG, PPARA
10	nervous system disease	12.7	PPARG, APOH
11	aneurysm disease	12.7	TNXB, ACE
12	fibromuscular dysplasia	12.6	APOH, ACE
13	malignant hypertension	12.6	ACE, APOH
14	acute myocarditis	12.6	APOH, ACE
15	carotid intimal medial thickness	12.6	PPARG, ACE
16	retinal artery occlusion	12.6	ACE, APOH
17	ischemic optic neuropathy	12.6	APOH, ACE
18	diabetes, type 2	12.6	PPARG, ACE
19	tangier disease	12.6	PPARA, PPARG
20	aortic atherosclerosis	12.6	ACE, PPARG
21	alcoholic hepatitis	12.5	ALDH2, AKR1A1, PPARA
22	connective tissue disease	12.5	TNXB, APOH
23	critical limb ischemia	12.5	ACE, APOH
24	hypertensive heart disease	12.5	ACE, PPARA
25	hypoalphalipoproteinemia	12.5	ACE, PPARA
26	nonalcoholic steatohepatitis	12.5	PPARA, AKR1A1, PPARG
27	neurocirculatory asthenia	12.4	ACE, TNXB
28	intermittent claudication	12.4	ACE, APOH
29	hepatic fibrosis renal cysts mental retardation	12.4	PPARA, PPARG, ALDH2
30	parkinson's disease	12.4	AKR1A1, ALDH2, PPARA
31	atrophic gastritis	12.3	AKR1A1, ACE, ALDH2
32	headache	12.3	APOH, AKR1A1, ACE
33	cutaneous lupus erythematosus	12.2	ACE, APOH
34	vasculitis	12.2	PPARG, APOH, PPARA
35	gastritis	12.2	ACE, AKR1A1, ALDH2
36	congenital heart defect	12.2	PPARA, AKR1A1, ACE
37	hyperhomocysteinemia	12.1	APOH, ACE, PPARG
38	cerebrovascular accident	12.1	APOH, ACE, PPARG
39	sleep apnea	12.1	PPARG, ACE, APOH
40	psoriatic arthritis	12.1	ACE, PPARG, APOH
41	cerebral infarction	12.1	ACE, APOH, PPARG
42	apnea	12.1	ACE, APOH, PPARG
43	bilirubin metabolic disorder	12.1	PPARA, PPARG, ALDH2, ACADM
44	retinal vein occlusion	12.0	APOH, ACE
45	galactosemia	12.0	ALDH2, PPARA, PPARG, AKR1A1
46	duodenitis	12.0	AKR1A1, ALDH2, PPARA
47	obesity, association with	12.0	PPARA, PPARG, ACE
48	hepatopulmonary syndrome	12.0	PPARA, ACE, PPARG
49	arteriosclerosis	12.0	PPARG, ACE, PPARA
50	glucose intolerance	12.0	PPARG, ACE, PPARA

Approved drugs:

Drug clinical trials:

Inferred drug relations via UMLS/NDF-RT:

^43 28 amrinone, amrinone lactate

MalaCards organs/tissues related to alcoholic cardiomyopathy:

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MGI Mouse Phenotypes related to alcoholic cardiomyopathy:

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id	Description	MGI Source Accession	Score	Top Affiliating Genes
1	mortality/aging	MP:0010768	6.9	ACE, PPARA, PPARG, TNXB, AKR1A1, APOH
2	homeostasis/metabolism phenotype	MP:0005376	6.5	APOH, ACADM, ACE, PPARA, PPARG, AKR1A1

Articles related to alcoholic cardiomyopathy:

id	Title	Authors	Year	Affiliating Genes
1	Anticardiolipin antibodies associated with alcoholic cardiomyopathy. (18666184)	de Godoy J.M.... BRAILE D.M.	2009	APOH
2	L-carnitine and cardiac metabolism and remodeling indices in alcoholic cardiomyopathy (19080238)	Jing L.... Song J.	2008	PPARG, PPARA, ACADM
3	Angiotensin-converting enzyme gene polymorphism is associated with vulnerability to alcoholic cardiomyopathy. (12204015)	Fernandez-Sola J.... Urbano-Marquez A.	2002	ACE
4	A transgenic model of acetaldehyde overproduction acc elerates alcohol cardiomyopathy. (10525098)	Liang Q.... Epstein P.N.	1999	AKR1A1

Genes related to alcoholic cardiomyopathy according to GeneCards:

id	Symbol	Description	Score	GeneCards Section Context
1	ACADM	acyl-CoA dehydrogenase, C-4 to C-12 straight chain	11.0	Publications
2	TNXB	tenascin XB	11.0
3	AKR1A1	aldo-keto reductase family 1, member A1 (aldehyde reductase)	11.0	Publications
4	ALDH2	aldehyde dehydrogenase 2 family (mitochondrial)	11.0
5	APOH	apolipoprotein H (beta-2-glycoprotein I)	11.0	Publications
6	PPARA	peroxisome proliferator-activated receptor alpha	11.0	Publications
7	ACE	angiotensin I converting enzyme (peptidyl-dipeptidase A) 1	11.0	Publications
8	PPARG	peroxisome proliferator-activated receptor gamma	11.0	Publications

Pathways related to alcoholic cardiomyopathy according to GeneDecks:

id	Pathway	Score	Top Affiliating Genes
1	Cyclophosphamide Pathway, Pharmacodynamics34	9.7	ALDH2, AKR1A1
2	beta-Alanine metabolism20	9.7	ACADM, ALDH2
3	Fatty acid metabolism20	9.7	ALDH2, ACADM
4	Propanoate metabolism20	9.6	ALDH2, ACADM
5	Valine, leucine and isoleucine degradation20	9.4	ALDH2, ACADM
6	PPAR signaling pathway20	9.1	PPARG, PPARA, ACADM

Compounds related to alcoholic cardiomyopathy according to GeneDecks:

(show top 50)    (show all 86)

id	Compound	Score	Top Affiliating Genes
1	propionaldehyde32	10.0	ALDH2, AKR1A1
2	benzaldehyde32 18	10.9	ALDH2, AKR1A1
3	gi26257032	9.8	PPARA, PPARG
4	mono(2-ethylhexyl)phthalate32	9.8	PPARA, PPARG
5	gw 192932	9.8	PPARA, PPARG
6	ragaglitazar32	9.8	PPARG, PPARA
7	bisphenol a diglycidyl ether32	9.8	PPARG, PPARA
8	(2S)-2-methoxy-3-{4-[2-(5-methyl-2-phenyl-1,3-oxazol-4-yl)ethoxy]-1-benzothiophen-7-yl}propanoic acid9 9	10.8	PPARA, PPARG
9	tetradecylthioacetic acid32	9.8	PPARA, PPARG
10	gw 764732 42	10.7	PPARA, PPARG
11	gw50151632	9.7	PPARG, PPARA
12	3-{5-methoxy-1-[(4-methoxyphenyl)sulfonyl]-1H-indol-3-yl}propanoic acid9 9	10.7	PPARG, PPARA
13	muraglitazar32	9.7	PPARG, PPARA
14	glyceraldehyde32 18	10.7	ALDH2, AKR1A1
15	prostaglandin j232	9.7	PPARG, PPARA
16	tesaglitazar32 42	10.7	PPARG, PPARA
17	palmitoylethanolamide32 42	10.7	PPARG, PPARA
18	clofibric acid32	9.6	PPARG, PPARA
19	carbacyclin32	9.5	PPARG, PPARA
20	octanoate32	9.4	ACADM, PPARA, PPARG
21	acetaldehyde32 18	10.4	PPARA, ALDH2, AKR1A1
22	pgj-232	9.4	PPARG, PPARA
23	4-hydroxynonenal32 18	10.3	PPARA, AKR1A1, ALDH2
24	wy1464332	9.3	PPARG, PPARA
25	carnitine32	9.3	PPARA, ACADM, PPARG
26	2-methylbutyryl-coa32 18	10.3	PPARG, PPARA, ACADM
27	eprosartan32 9 9	11.3	PPARG, ACE
28	octanoyl-coa32 18	10.3	ACADM, PPARG, PPARA
29	linoleic acid32 18	10.3	PPARG, PPARA, ACADM
30	(2E)-Tetradecenoyl-CoA18	9.3	PPARG, PPARA, ACADM
31	(2E)-Octenoyl-CoA18	9.3	PPARA, ACADM, PPARG
32	phenobarbital32 9 9	11.3	PPARG, PPARA, AKR1A1
33	(2E)-Decenoyl-CoA18	9.3	PPARG, PPARA, ACADM
34	(2E)-Dodecenoyl-CoA18	9.3	ACADM, PPARA, PPARG
35	stearoyl-coa32 18	10.2	PPARG, PPARA, ACADM
36	(2E)-Hexadecenoyl-CoA18	9.2	PPARG, PPARA, ACADM
37	alpha tocopherol32	9.0	PPARA, ALDH2, APOH
38	palmitate32	9.0	PPARG, PPARA, ACADM
39	telmisartan32 9 9	11.0	PPARA, ACE, PPARG
40	folate32	8.9	ALDH2, AKR1A1, PPARA, APOH
41	metformin32 34 9 9	11.9	PPARG, PPARA, ACE
42	retinoid32	8.9	PPARA, ALDH2, AKR1A1, PPARG
43	glutamine32	8.6	ACADM, ALDH2, PPARG, AKR1A1
44	arginine32	8.5	ACADM, AKR1A1, PPARA, APOH, ALDH2
45	glutamate32	8.5	ALDH2, AKR1A1, ACADM, APOH, PPARA
46	prostacyclin32	8.4	APOH, PPARG, ACE, PPARA
47	fatty acid32	8.2	PPARA, PPARG, APOH, ACADM
48	creatinine32	8.1	AKR1A1, ALDH2, ACE, PPARA, APOH
49	cholesterol32 9 18 9	10.9	PPARA, PPARG, ALDH2, APOH, ACE
50	lipid32	7.2	APOH, ACADM, ACE, PPARA, PPARG, AKR1A1

Biological processes related to alcoholic cardiomyopathy according to GeneDecks:

id	Name	GO ID	Score	Top Affiliating Genes
1	triglyceride metabolic process	GO:006641	9.6	APOH, TNXB
2	negative regulation of receptor biosynthetic process	GO:010871	9.4	PPARG, PPARA
3	negative regulation of sequestering of triglyceride	GO:010891	9.4	PPARG, PPARA
4	positive regulation of fatty acid oxidation	GO:046321	9.3	PPARG, PPARA
5	negative regulation of cholesterol storage	GO:010887	9.2	PPARA, PPARG
6	negative regulation of macrophage derived foam cell differentiation	GO:010745	9.0	PPARG, PPARA

Molecular functions related to alcoholic cardiomyopathy according to GeneDecks:

id	Name	GO ID	Score	Top Affiliating Genes
1	ligand-activated sequence-specific DNA binding RNA polymerase II transcription factor activity	GO:004879	9.3	PPARG, PPARA
2	drug binding	GO:008144	8.2	PPARG, PPARA, ACE