MCID: ALC010
MIFTS: 38

Alcoholic Cardiomyopathy malady

Category: Cardiovascular diseases

Aliases & Classifications for Alcoholic Cardiomyopathy

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Aliases & Descriptions for Alcoholic Cardiomyopathy:

Name: Alcoholic Cardiomyopathy 11 13
Cardiomyopathy, Alcoholic 37 66
 
Dilated Cardiomyopathy Secondary to Alcohol 11
Alcohol-Induced Heart Muscle Disease 11

Classifications:



External Ids:

Disease Ontology11 DOID:12935
ICD1028 I42.6
ICD9CM30 425.5
SNOMED-CT60 155352001, 83521008
MeSH37 D002310
NCIt43 C53653

Summaries for Alcoholic Cardiomyopathy

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Wikipedia:69 Alcoholic cardiomyopathy is a disease in which the chronic long-term abuse of alcohol (i.e. ethanol)... more...

MalaCards based summary: Alcoholic Cardiomyopathy, also known as cardiomyopathy, alcoholic, is related to cardiomyopathy and deafness, x-linked 5. An important gene associated with Alcoholic Cardiomyopathy is PPARA (Peroxisome Proliferator Activated Receptor Alpha), and among its related pathways are Nuclear Receptor transcription pathway and Nuclear receptors in lipid metabolism and toxicity. Affiliated tissues include heart, liver and skeletal muscle, and related mouse phenotypes are adipose tissue and renal/urinary system.

Related Diseases for Alcoholic Cardiomyopathy

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Graphical network of the top 20 diseases related to Alcoholic Cardiomyopathy:



Diseases related to alcoholic cardiomyopathy

Symptoms for Alcoholic Cardiomyopathy

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Drugs & Therapeutics for Alcoholic Cardiomyopathy

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Drugs for Alcoholic Cardiomyopathy (from DrugBank, HMDB, Dgidb, PharmGKB, IUPHAR, NovoSeek, BitterDB):

idNameStatusPhaseClinical TrialsCas NumberPubChem Id
1
SpironolactonePhase 42171952-01-7, 52-01-75833
Synonyms:
4-18-00-01601 (Beilstein Handbook Reference)
4-Pregnen-21-oic acid-17alpha-ol-3-one-7alpha-thiol gamma-lactone 7-acetate
496916-40-6
52-01-7
7-alpha-Acetylthio-3-oxo-17-alpha-pregn-4-ene-21,17-beta-carbolactone
7alpha-(acetylsulfanyl)-3-oxo-17alpha-pregn-4-ene-21,17-carbolactone
AB00513806
AC-4214
AC1L1L8Q
Abbolactone
Acelat
Aldace
Aldactazide
Aldactide
Aldactone
Aldactone (TN)
Aldactone A
Alderon
Aldopur
Almatol
Alphapharm Brand of Spironolactone
Alpharma Brand of Spironolactone
Alter Brand of Spironolactone
Altex
Aquareduct
Ashbourne Brand of Spironolactone
Azupharma Brand of Spironolactone
BIDD:PXR0071
BPBio1_000194
BRD-K90027355-001-03-4
BRN 0057767
BSPBio_000176
C07310
C24H32O4S
CHEBI:428201
CHEBI:45692
CHEBI:9241
CHEMBL1393
CID5833
CPD000471892
Cardel Brand of Spironolactone
D00443
D013148
DB00421
Deverol
Dexo Brand of Spironolactone
Diatensec
Dira
Duraspiron
EINECS 200-133-6
Espironolactona
Espironolactona Alter
Espironolactona Mundogen
Espironolactona [INN-Spanish]
Euteberol
Flumach
Frumikal
Generosan Brand of Spironolactone
HMS1568I18
HMS2090N21
HSDB 3184
Hormosan Brand of Spironolactone
I06-1970
Jenapharm Brand of Spironolactone
Jenaspiron
LS-118614
LT00772287
Lacalmin
Lacdene
Laractone
MLS001074672
MLS001333253
MLS001333254
MLS002153245
MLS002207058
Mayoly-Spindler Brand of Spironolactone
Melarcon
Merck dura Brand of Spironolactone
Mundogen Brand of Spironolactone
NCGC00164397-01
 
NCGC00164397-02
NSC 150399
NSC150399
Nefurofan
Novo Spiroton
Novo-Spiroton
NovoSpiroton
Novopharm Brand of Spironolactone
Osyrol
Pfizer Brand of Spironolactone
Pharmafrid Brand of Spironolactone
Practon
Prestwick0_000128
Prestwick1_000128
Prestwick2_000128
Prestwick3_000128
Roche Brand of Spironolactone
S0260
S3378_SIGMA
SAM002264648
SC 9420
SC-9420
SC9420
SMR000471892
SNL
SPBio_002115
Sagisal
Searle Brand of Spironolactone
Sincomen
Spiractin
Spiresis
Spiretic
Spiridon
Spiro L.U.T.
Spiro(17H-cyclopenta(a)phenauthrene-17,2'-(3'H)-furan)
Spiro-Tablinen
Spiro[17H-cyclopenta[a]phenauthrene-17,2'-(3'H)-furan]
Spirobeta
Spiroctan
Spiroctanie
Spiroderm
Spirogamma
Spirolactone
Spirolakton
Spirolang
Spirolone
Spirone
Spirono Isis
Spirono-Isis
Spironocompren
Spironolactone
Spironolactone (JP15/USP/INN)
Spironolactone A
Spironolactone [BAN:INN:JAN]
Spironolactone [INN:BAN:JAN]
Spironolactonum
Spironolactonum [INN-Latin]
Spironolattone
Spironolattone [DCIT]
Spironone
Spirospare
Sprioderm
Supra-puren
Suracton
UNII-27O7W4T232
Uractone
Urusonin
Veroshpiron
Verospiron
Verospirone
Verospirone Opianin
WLN: L E5 B666 FX OV MUTJ A1 E1 KSV1 F-& CT5VOXTJ
Worwag Brand of Spironolactone
Xenalon
ZINC03861599
betapharm Brand of Spironolactone
ct Arzneimittel Brand of Spironolactone
ct-Arzneimittel Brand of Spironolactone
spiro von ct
spironolactone
spironolattone
von ct, spiro
2diureticsPhase 41338

Interventional clinical trials:

idNameStatusNCT IDPhase
1Clinical Trial Studying the Effects of Spironolactone on Heart and Skeletal Muscle Function in Chronic AlcoholicsSuspendedNCT00226109Phase 4
2Subclinical Myocardial Dysfunction in Patients With Hepatic CirrhosisCompletedNCT01713478
3Adapted Physical Activity Effect on Aerobic Function and in Patients in Pre Liver TransplantationRecruitingNCT02567591
4Prospective Analysis Of Cardiac Function In Cirrhotic Patients By Echocardiography And Its Correlation With EventsEnrolling by invitationNCT01433848

Search NIH Clinical Center for Alcoholic Cardiomyopathy


Cochrane evidence based reviews: cardiomyopathy, alcoholic

Genetic Tests for Alcoholic Cardiomyopathy

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Anatomical Context for Alcoholic Cardiomyopathy

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MalaCards organs/tissues related to Alcoholic Cardiomyopathy:

34
Heart, Liver, Skeletal muscle

Animal Models for Alcoholic Cardiomyopathy or affiliated genes

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MGI Mouse Phenotypes related to Alcoholic Cardiomyopathy:

39
idDescriptionMGI Source AccessionScoreTop Affiliating Genes
1MP:00053758.9ACE, MSTN, PPARA, PPARG
2MP:00053678.6ACE, ALDH2, MSTN, PPARG
3MP:00020068.4ACE, ALDH2, PPARG, TNXB
4MP:00053708.1ACADM, ACE, ALDH2, MSTN, PPARA, PPARG
5MP:00053857.5ACADM, ACE, MSTN, PPARA, PPARG, RGS6
6MP:00107686.8ACADM, ACE, ALDH2, MSTN, PPARA, PPARG

Publications for Alcoholic Cardiomyopathy

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Articles related to Alcoholic Cardiomyopathy:

(show top 50)    (show all 143)
idTitleAuthorsYear
1
NOX2 amplifies acetaldehyde-mediated cardiomyocyte mitochondrial dysfunction in alcoholic cardiomyopathy. (27624556)
2016
2
Alcoholic cardiomyopathy : The result of dosage and individual predisposition. (27582365)
2016
3
Left Ventricular Strain and Rotation by 2-D Speckle Tracking Echocardiography Identify Early Alcoholic Cardiomyopathy. (27156014)
2016
4
Investigation of microRNA Expression Profiles Associated with Human Alcoholic Cardiomyopathy. (25791397)
2015
5
Natural history and prognostic factors in alcoholic cardiomyopathy. (25458176)
2015
6
Alcoholic cardiomyopathy. (25228956)
2014
7
Alcoholic cardiomyopathy: pathophysiologic insights. (24671642)
2014
8
Alcoholic cardiomyopathy. (24155001)
2013
9
Alcoholic cardiomyopathy: a review. (21962423)
2011
10
Increased myostatin activity and decreased myocyte proliferation in chronic alcoholic cardiomyopathy. (21463333)
2011
11
Tenascin-x facilitates myocardial fibrosis and cardiac remodeling through transforming growth factor-I^1 and peroxisome proliferator-activated receptor I^ in alcoholic cardiomyopathy. (21362339)
2011
12
Evaluation of myocyte proliferation in alcoholic cardiomyopathy: telomerase enzyme activity (TERT) compared with Ki-67 expression. (21733836)
2011
13
Alcoholic cardiomyopathy. (20308914)
2010
14
WITHDRAWN: Oxidative stress-induced apoptosis is mediated by calpains in alcoholic cardiomyopathy. (21172724)
2010
15
Alcoholic cardiomyopathy: acetaldehyde, insulin insensitization and ER stress. (18479704)
2008
16
A murine model of alcoholic cardiomyopathy: a role for zinc and metallothionein in fibrosis. (16049317)
2005
17
Experimental Assessment of the Role of Acetaldehyde in Alcoholic Cardiomyopathy. (12734561)
2003
18
The effect of controlled drinking in alcoholic cardiomyopathy. (11827495)
2002
19
Treatment of heart failure and ascites with ultrafiltration in patients with intractable alcoholic cardiomyopathy. (11887087)
2002
20
Echocardiographic evolution of left ventricular and left atrial thrombi in a patient with left ventricular dysfunction due to alcoholic cardiomyopathy, chronic atrial fibrillation and multiple non-fatal systemic embolisms. (11357926)
2001
21
Long-term prognosis in patients with alcoholic cardiomyopathy and severe heart failure after total abstinence. (9164905)
1997
22
Comparison of alcoholic cardiomyopathy in women versus men. (9285662)
1997
23
Alcoholic cardiomyopathy: is outcome linked to stimulus withdrawal? (8732367)
1996
24
Alcoholic cardiomyopathy: clinical and experimental pathological changes. (8805004)
1996
25
Changes in cardiac signal transduction systems in chronic ethanol treatment preceding the development of alcoholic cardiomyopathy. (8805003)
1996
26
Alcoholic cardiomyopathy. (8198205)
1994
27
Alcoholic cardiomyopathy. (8086332)
1994
28
Relationship between morbidity and mortality due to alcoholic cardiomyopathy and alcohol consumption in Australia. (2343798)
1990
29
Risk factors in alcoholic cardiomyopathy. (2705634)
1989
30
Alcoholic cardiomyopathy. (2812553)
1989
31
Alcoholic cardiomyopathy and sudden cardiac death. (3711541)
1986
32
Regression of severe alcoholic cardiomyopathy after abstinence of 10 weeks. (3530014)
1986
33
Gated radionuclide angiocardiography in the noninvasive evaluation of a partially reversible alcoholic cardiomyopathy. (3728516)
1986
34
Effect of chronic ethanol ingestion on the metabolism of copper, iron, manganese, selenium, and zinc in an animal model of alcoholic cardiomyopathy. (6502742)
1984
35
Liver disease in alcoholic cardiomyopathy: evidence against cirrhosis. (6840753)
1983
36
Impaired myocardial performance and response to calcium in experimental alcoholic cardiomyopathy. (7321050)
1981
37
Alcohol and malnutrition in the pathogenesis of experimental alcoholic cardiomyopathy. (7370094)
1980
38
Improvement of left ventricular function in alcoholic cardiomyopathy documented by serial gated cardiac pool scanning. (292382)
1979
39
Alcoholic cardiomyopathy. (884942)
1977
40
Alcoholic cardiomyopathy in mice. Electron microscopic observations. (559095)
1977
41
Alcoholic cardiomyopathy: the effect of ethanol and acetaldehyde on cardiac protein synthesis. (1241620)
1975
42
Electrocardiographic abnormalities in alcoholic cardiomyopathy. A study of 65 patients. (125185)
1975
43
Myocardial lesions in idiopathic and alcoholic cardiomyopathy. Study by ventricular septal biopsy. (5061696)
1972
44
Alcoholic cardiomyopathy managed with prolonged bed rest. (4254303)
1971
45
Alcoholic cardiomyopathy. Concept of the disease and its treatment. (4925694)
1971
46
Alcoholic cardiomyopathy: a critical review. (4921395)
1970
47
Alcoholic cardiomyopathy. (5706476)
1968
48
ALCOHOLIC CARDIOMYOPATHY; A HISTOCHEMICAL STUDY. (14296641)
1965
49
ALCOHOLIC CARDIOMYOPATHY. (14317452)
1965
50
Alcoholic cardiomyopathy in a man with Gaustad's syndrome. (13586663)
1958

Variations for Alcoholic Cardiomyopathy

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Expression for genes affiliated with Alcoholic Cardiomyopathy

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Search GEO for disease gene expression data for Alcoholic Cardiomyopathy.

Pathways for genes affiliated with Alcoholic Cardiomyopathy

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Pathways related to Alcoholic Cardiomyopathy according to GeneCards Suite gene sharing:

idSuper pathwaysScoreTop Affiliating Genes
1
Show member pathways
9.7PPARA, PPARG
29.7PPARA, PPARG
3
Show member pathways
9.3ACADM, ALDH2
4
Show member pathways
9.3ACADM, ALDH2
5
Show member pathways
9.2ACADM, PPARA, PPARG

GO Terms for genes affiliated with Alcoholic Cardiomyopathy

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Biological processes related to Alcoholic Cardiomyopathy according to GeneCards Suite gene sharing:

(show all 15)
idNameGO IDScoreTop Affiliating Genes
1negative regulation of receptor biosynthetic processGO:001087110.3PPARA, PPARG
2negative regulation of cholesterol storageGO:001088710.3PPARA, PPARG
3negative regulation of sequestering of triglycerideGO:001089110.3PPARA, PPARG
4positive regulation of fatty acid oxidationGO:004632110.2PPARA, PPARG
5steroid hormone mediated signaling pathwayGO:004340110.2PPARA, PPARG
6negative regulation of macrophage derived foam cell differentiationGO:001074510.1PPARA, PPARG
7negative regulation of protein bindingGO:003209110.0ACE, PPARA
8lipid homeostasisGO:005508810.0ACADM, PPARG
9response to coldGO:00094099.9ACADM, PPARG
10regulation of blood pressureGO:00082179.9ACE, PPARG
11response to estrogenGO:00436279.7MSTN, PPARG
12regulation of circadian rhythmGO:00427529.7PPARA, PPARG
13fatty acid metabolic processGO:00066319.6PPARA, TNXB
14response to starvationGO:00425949.6ACADM, PPARG
15heart developmentGO:00075078.9ACADM, PPARA, PPARG

Molecular functions related to Alcoholic Cardiomyopathy according to GeneCards Suite gene sharing:

idNameGO IDScoreTop Affiliating Genes
1RNA polymerase II transcription factor activity, ligand-activated sequence-specific DNA bindingGO:000487910.1PPARA, PPARG
2steroid hormone receptor activityGO:000370710.1PPARA, PPARG
3electron carrier activityGO:00090559.4ACADM, ALDH2
4drug bindingGO:00081449.3ACE, PPARA, PPARG

Sources for Alcoholic Cardiomyopathy

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2CDC
6CNVD
10DGIdb
15ExPASy
16FDA
17FMA
25GTR
26HGMD
27HMDB
28ICD10
29ICD10 via Orphanet
30ICD9CM
31IUPHAR
32KEGG
35MedGen
37MeSH
38MESH via Orphanet
39MGI
42NCI
43NCIt
44NDF-RT
47NINDS
48Novoseek
50OMIM
51OMIM via Orphanet
55PubMed
56QIAGEN
61SNOMED-CT via Orphanet
65Tumor Gene Family of Databases
66UMLS
67UMLS via Orphanet