MCID: ALC010
MIFTS: 41

Alcoholic Cardiomyopathy malady

Cardiovascular diseases category

Aliases & Classifications for Alcoholic Cardiomyopathy

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Aliases & Descriptions for Alcoholic Cardiomyopathy:

Name: Alcoholic Cardiomyopathy 8
Dilated Cardiomyopathy Secondary to Alcohol 8
 
Alcohol-Induced Heart Muscle Disease 8
Cardiomyopathy, Alcoholic 61


Classifications:



External Ids:

Disease Ontology8 DOID:12935
NCIt39 C53653
ICD9CM27 425.5
SNOMED-CT56 83521008, 155352001
MeSH33 D002310
ICD1025 I42.6

Summaries for Alcoholic Cardiomyopathy

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Wikipedia:64 Alcoholic cardiomyopathy is a disease in which the chronic long-term abuse of alcohol (i.e. ethanol)... more...

MalaCards based summary: Alcoholic Cardiomyopathy, also known as dilated cardiomyopathy secondary to alcohol, is related to hypertensive heart disease and coronary artery disease. An important gene associated with Alcoholic Cardiomyopathy is MSTN (myostatin), and among its related pathways are Regulation of Cholesterol Biosynthesis by SREBP (SREBF) and Adipogenesis. The compounds beta blocking agents and tzd18 have been mentioned in the context of this disorder. Affiliated tissues include heart and liver, and related mouse phenotypes are muscle and adipose tissue.

Related Diseases for Alcoholic Cardiomyopathy

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Diseases related to Alcoholic Cardiomyopathy via text searches within MalaCards or GeneCards Suite gene sharing:

(show all 42)
idRelated DiseaseScoreTop Affiliating Genes
1hypertensive heart disease30.2PPARA, ACE
2coronary artery disease29.7PPARA, PPARG, ACE
3retinal artery occlusion10.4APOH
4hypoalphalipoproteinemia10.3PPARA
5atrial fibrillation10.2
6cerebrovascular disease10.1ACE, APOH
7non-suppurative otitis media10.1PPARA, MSTN
8nephritis10.1ACE, APOH
9liver disease10.0
10hypersplenism10.0
11artery disease10.0
12myocarditis10.0
13myopathy10.0
14pulmonary embolism10.0
15hypercholesterolemia, familial10.0ACE, PPARA
16systemic scleroderma10.0ACE, APOH
17proteinuria10.0APOH, ACE
18congenital heart disease10.0PPARA, ACE
19tangier disease10.0PPARA, PPARG
20liposarcoma10.0PPARA, PPARG
21lipodystrophy10.0PPARG, PPARA
22glucose intolerance10.0PPARA, PPARG
23fatty liver disease9.9PPARA, PPARG
24hypertriglyceridemia9.9PPARG, PPARA
25polycystic ovary syndrome9.9PPARA, PPARG
26alzheimer disease9.9PPARA, PPARG
27noonan syndrome 19.9ACADM, ACE
28adenomatous polyposis coli9.9PPARG, PPARA
29idiopathic edema9.8PPARA, PPARG, ACE
30hyperinsulinism9.8PPARA, PPARG
31lipid metabolism disorder9.8PPARG, PPARA, ACE
32familial hyperlipidemia9.8PPARA, ACE, PPARG
33obesity9.8MSTN, PPARA, PPARG
34microvascular complications of diabetes 39.8ACE, PPARG, PPARA
35hypertension, essential9.8PPARG, PPARA, ACE
36hyperglycemia9.8ACE, PPARA, PPARG
37diabetes mellitus, noninsulin-dependent9.8ACE, PPARA, PPARG
38primary hyperoxaluria9.7PPARA, PPARG, ACE
39diabetes mellitus, insulin-dependent9.7PPARG, ACE, PPARA
40metabolic syndrome x9.6MSTN, PPARA, PPARG, ACADM
41vascular disease9.6PPARA, PPARG, APOH, ACE
42atherosclerosis9.5PPARG, PPARA, APOH, ACE

Graphical network of the top 20 diseases related to Alcoholic Cardiomyopathy:



Diseases related to alcoholic cardiomyopathy

Symptoms for Alcoholic Cardiomyopathy

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Drugs & Therapeutics for Alcoholic Cardiomyopathy

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Drug clinical trials:

Search ClinicalTrials for Alcoholic Cardiomyopathy

Search NIH Clinical Center for Alcoholic Cardiomyopathy

Genetic Tests for Alcoholic Cardiomyopathy

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Anatomical Context for Alcoholic Cardiomyopathy

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MalaCards organs/tissues related to Alcoholic Cardiomyopathy:

31
Heart, Liver

Animal Models for Alcoholic Cardiomyopathy or affiliated genes

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MGI Mouse Phenotypes related to Alcoholic Cardiomyopathy:

35
idDescriptionMGI Source AccessionScoreTop Affiliating Genes
1MP:00053698.2ACADM, MSTN, PPARA, PPARG
2MP:00053758.0ACE, MSTN, PPARA, PPARG
3MP:00053707.8ACE, ACADM, MSTN, PPARA, PPARG
4MP:00053857.3PPARG, PPARA, MSTN, ACADM, ACE
5MP:00053767.2PPARG, PPARA, APOH, MSTN, ACADM, ACE
6MP:00107687.1PPARG, PPARA, APOH, MSTN, ACADM, ACE

Publications for Alcoholic Cardiomyopathy

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Articles related to Alcoholic Cardiomyopathy:

(show top 50)    (show all 135)
idTitleAuthorsYear
1
Investigation of microRNA Expression Profiles Associated with Human Alcoholic Cardiomyopathy. (25791397)
2015
2
Alcoholic cardiomyopathy. (24155001)
2013
3
Alcoholic cardiomyopathy and cardiovascular events - an insight from the Liptov region. (23731046)
2013
4
Sensitization to cross-reactive carbohydrate determinants in 2 patients with Hymenoptera venom allergy and alcoholic cardiomyopathy. (22901863)
2012
5
Alcoholic cardiomyopathy: a review. (21962423)
2011
6
Increased myostatin activity and decreased myocyte proliferation in chronic alcoholic cardiomyopathy. (21463333)
2011
7
Functional proteomic analysis reveals sex-dependent differences in structural and energy-producing myocardial proteins in rat model of alcoholic cardiomyopathy. (21245415)
2011
8
Carnitine regulates myocardial metabolism by Peroxisome Proliferator-Activated Receptor-alpha (PPARalpha) in alcoholic cardiomyopathy. (21169901)
2011
9
Tenascin-x facilitates myocardial fibrosis and cardiac remodeling through transforming growth factor-I^1 and peroxisome proliferator-activated receptor I^ in alcoholic cardiomyopathy. (21362339)
2011
10
Evaluation of myocyte proliferation in alcoholic cardiomyopathy: telomerase enzyme activity (TERT) compared with Ki-67 expression. (21733836)
2011
11
With computed tomography confirmed anterolateral left ventricular pseudoaneurysm in patient with dilatative alcoholic cardiomyopathy. (22933953)
2011
12
Anticardiolipin antibodies associated with alcoholic cardiomyopathy. (18666184)
2009
13
Alcoholic cardiomyopathy: acetaldehyde, insulin insensitization and ER stress. (18479704)
2008
14
L-carnitine and cardiac metabolism and remodeling indices in alcoholic cardiomyopathy]. (19080238)
2008
15
Angiotensin II type 1 receptor blockade prevents alcoholic cardiomyopathy. (16831986)
2006
16
Scintigraphic evaluation of cardiac metabolism and sympathetic nerve function in alcoholic cardiomyopathy. (16679703)
2006
17
Ethanol and acetaldehyde in alcoholic cardiomyopathy: from bad to ugly en route to oxidative stress. (15282111)
2004
18
Gender differences in alcoholic cardiomyopathy. (11859686)
2002
19
A transgenic model of acetaldehyde overproduction accelerates alcohol cardiomyopathy. (10525098)
1999
20
Alcoholic cardiomyopathy: is outcome linked to stimulus withdrawal? (8732367)
1996
21
Alcoholic cardiomyopathy in rats: inotropic responses to phenylephrine, glucagon, ouabain, and dobutamine. (3437459)
1987
22
Alcoholic cardiomyopathy and sudden cardiac death. (3711541)
1986
23
Effect of chronic ethanol ingestion on the metabolism of copper, iron, manganese, selenium, and zinc in an animal model of alcoholic cardiomyopathy. (6502742)
1984
24
Improvement of left ventricular function in alcoholic cardiomyopathy documented by serial gated cardiac pool scanning. (292382)
1979
25
Pulsus alternans induced by glyceryl trinitrate paste in a patient with alcoholic cardiomyopathy. (154916)
1979
26
Alcoholic cardiomyopathy. (884942)
1977
27
Alcoholic cardiomyopathy. (890189)
1977
28
The small coronary arteries in alcoholic cardiomyopathy. (910681)
1977
29
Alcohol and the heart: alcoholic cardiomyopathy. (926061)
1977
30
Alcoholic cardiomyopathy: a nursing approach. (243794)
1977
31
Alcoholic cardiomyopathy in mice. Myocardial glycogen, lipids and certain enzymes. (17013)
1977
32
Reversibility of alcoholic cardiomyopathy. II. Role of atrial fibrillation. (983967)
1976
33
Alcoholic cardiomyopathy: the effect of ethanol and acetaldehyde on cardiac protein synthesis. (1241620)
1975
34
Editorial: Alcoholic cardiomyopathy. (4441876)
1974
35
The incidence of myocardial abnormalities in man related to the level of ethanol consumption. A proposal of a diagnostic criterion of alcoholic cardiomyopathy. (4140250)
1974
36
Letter: Alcoholic cardiomyopathy. (4277554)
1974
37
Alcoholic cardiomyopathy. II. The inhibition of cardiac microsomal protein synthesis by acetaldehyde. (4828692)
1974
38
Heart block in alcoholic cardiomyopathy. (4413642)
1974
39
Alcoholic cardiomyopathy: an introductory review. (4550483)
1972
40
Alcoholic cardiomyopathy. (4944526)
1971
41
Alcoholic cardiomyopathy managed with prolonged bed rest. (4254303)
1971
42
Alcoholic cardiomyopathy. Concept of the disease and its treatment. (4925694)
1971
43
Alcoholic cardiomyopathy: a critical review. (4921395)
1970
44
Alcoholic cardiomyopathy. (5706476)
1968
45
Alcoholic cardiomyopathy. (4166114)
1967
46
Alcoholic cardiomyopathy. (6051265)
1967
47
ALCOHOLIC CARDIOMYOPATHY; A HISTOCHEMICAL STUDY. (14296641)
1965
48
ALCOHOLIC CARDIOMYOPATHY. (14317452)
1965
49
Alcoholic cardiomyopathy. (14447338)
1961
50
Alcoholic cardiomyopathy in a man with Gaustad's syndrome. (13586663)
1958

Variations for Alcoholic Cardiomyopathy

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Expression for genes affiliated with Alcoholic Cardiomyopathy

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Search GEO for disease gene expression data for Alcoholic Cardiomyopathy.

Pathways for genes affiliated with Alcoholic Cardiomyopathy

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Compounds for genes affiliated with Alcoholic Cardiomyopathy

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Compounds related to Alcoholic Cardiomyopathy according to GeneCards Suite gene sharing:

(show top 50)    (show all 118)
idCompoundScoreTop Affiliating Genes
1beta blocking agents509.7ACE, PPARA
2tzd18289.5PPARG, PPARA
3gw409544289.5PPARA, PPARG
4mk-0767289.5PPARA, PPARG
5gi262570449.5PPARG, PPARA
6ragaglitazar44 2810.5PPARA, PPARG
7gw 1929449.5PPARA, PPARG
8mono(2-ethylhexyl)phthalate449.5PPARA, PPARG
9ly-510929289.5PPARA, PPARG
10ad-5061289.4PPARG, PPARA
11reglitazar289.4PPARG, PPARA
12farglitazar289.4PPARG, PPARA
13ly-465608289.4PPARG, PPARA
14bisphenol a diglycidyl ether449.4PPARG, PPARA
15tetradecylthioacetic acid449.4PPARG, PPARA
16gw 764744 6010.4PPARA, PPARG
17gw9578289.4PPARA, PPARG
18gw50151644 2810.4PPARA, PPARG
19prostaglandin j2449.4PPARA, PPARG
20tesaglitazar449.4PPARG, PPARA
21octanoate449.0ACADM, PPARA, PPARG
22telmisartan44 28 1111.0PPARA, PPARG, ACE
23carnitine448.9PPARA, PPARG, ACADM
24Lauroyl-CoA248.9PPARA, ACADM, PPARG
25Isovaleryl-CoA248.9PPARG, PPARA, ACADM
26metformin44 50 1110.9ACE, PPARA, PPARG
27Isobutyryl-CoA248.9PPARG, PPARA, ACADM
28Glutaconyl-CoA248.9PPARA, PPARG, ACADM
29Hexanoyl-CoA248.9ACADM, PPARA, PPARG
30Nonanoyl-CoA248.9ACADM, PPARA, PPARG
31Undecanoyl-CoA248.9PPARA, ACADM, PPARG
32pravastatin44 50 28 24 1112.9ACE, PPARA, PPARG
33trans-Octadec-2-enoyl-CoA248.8PPARG, ACADM, PPARA
34Tetracosanoyl-CoA248.8PPARG, PPARA, ACADM
35Pentanoyl-CoA248.8PPARG, PPARA, ACADM
362-Methylhexanoyl-CoA248.8ACADM, PPARG, PPARA
372-methylbutyryl-coa44 249.8ACADM, PPARA, PPARG
38Butyryl-CoA248.8ACADM, PPARA, PPARG
39Decanoyl-CoA (n-C10:0CoA)248.7ACADM, PPARA, PPARG
40octanoyl-coa44 249.7ACADM, PPARA, PPARG
41Eicosanoyl-CoA248.6PPARG, PPARA, ACADM
423Z-dodecenoyl-CoA248.6ACADM, PPARG, PPARA
43(2E)-Dodecenoyl-CoA248.6ACADM, PPARA, PPARG
44(2E)-Octenoyl-CoA248.5ACADM, PPARA, PPARG
45prostacyclin448.4PPARG, APOH, PPARA, ACE
46aspirin44 50 28 2411.4PPARA, ACE, APOH, PPARG
47fatty acid448.4ACADM, APOH, PPARA, PPARG
48(2E)-Decenoyl-CoA248.3ACADM, PPARA, PPARG
49lipid447.9APOH, PPARA, ACADM, PPARG, ACE
50glucose447.6MSTN, APOH, PPARG, ACADM, ACE, PPARA

GO Terms for genes affiliated with Alcoholic Cardiomyopathy

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Biological processes related to Alcoholic Cardiomyopathy according to GeneCards Suite gene sharing:

(show all 10)
idNameGO IDScoreTop Affiliating Genes
1response to coldGO:00094099.3PPARG, ACADM
2negative regulation of receptor biosynthetic processGO:00108719.3PPARA, PPARG
3response to estrogenGO:00436279.2MSTN, PPARG
4positive regulation of fatty acid oxidationGO:00463219.2PPARG, PPARA
5negative regulation of sequestering of triglycerideGO:00108919.2PPARG, PPARA
6negative regulation of cholesterol storageGO:00108879.2PPARA, PPARG
7negative regulation of macrophage derived foam cell differentiationGO:00107459.1PPARA, PPARG
8regulation of blood pressureGO:00082179.0ACE, PPARG
9lipid metabolic processGO:00066299.0PPARA, PPARG
10positive regulation of transcription, DNA-templatedGO:00458938.3PPARG, PPARA, MSTN

Molecular functions related to Alcoholic Cardiomyopathy according to GeneCards Suite gene sharing:

idNameGO IDScoreTop Affiliating Genes
1heparin bindingGO:00082019.5MSTN, APOH
2ligand-activated sequence-specific DNA binding RNA polymerase II transcription factor activityGO:00048799.1PPARA, PPARG
3lipid bindingGO:00082899.0APOH, PPARA
4steroid hormone receptor activityGO:00037079.0PPARA, PPARG
5identical protein bindingGO:00428029.0APOH, MSTN, ACADM
6drug bindingGO:00081448.6ACE, PPARA, PPARG

Sources for Alcoholic Cardiomyopathy

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2CDC
12ExPASy
13FDA
14FMA
22GTR
23HGMD
24HMDB
25ICD10
26ICD10 via Orphanet
27ICD9CM
28IUPHAR
29KEGG
33MeSH
34MESH via Orphanet
35MGI
38NCI
39NCIt
40NDF-RT
43NINDS
44Novoseek
46OMIM
47OMIM via Orphanet
51PubMed
52QIAGEN
57SNOMED-CT via Orphanet
61UMLS
62UMLS via Orphanet