MCID: ALC010
MIFTS: 38

Alcoholic Cardiomyopathy

Categories: Cardiovascular diseases

Aliases & Classifications for Alcoholic Cardiomyopathy

MalaCards integrated aliases for Alcoholic Cardiomyopathy:

Name: Alcoholic Cardiomyopathy 12 14
Cardiomyopathy, Alcoholic 42 69
Dilated Cardiomyopathy Secondary to Alcohol 12
Alcohol-Induced Heart Muscle Disease 12

Classifications:



External Ids:

Disease Ontology 12 DOID:12935
ICD10 33 I42.6
ICD9CM 35 425.5
MeSH 42 D002310
NCIt 47 C53653
SNOMED-CT 64 155352001 83521008
UMLS 69 C0007192

Summaries for Alcoholic Cardiomyopathy

MalaCards based summary : Alcoholic Cardiomyopathy, also known as cardiomyopathy, alcoholic, is related to cardiomyopathy and fgb-related congenital afibrinogenemia. An important gene associated with Alcoholic Cardiomyopathy is PPARA (Peroxisome Proliferator Activated Receptor Alpha), and among its related pathways/superpathways are PPAR signaling pathway and beta-Alanine metabolism (KEGG). The drugs Spironolactone and diuretics have been mentioned in the context of this disorder. Affiliated tissues include heart, liver and skeletal muscle, and related phenotypes are cardiovascular system and homeostasis/metabolism

Wikipedia : 72 Alcoholic cardiomyopathy is a disease in which the chronic long-term abuse of alcohol (i.e., ethanol)... more...

Related Diseases for Alcoholic Cardiomyopathy

Graphical network of the top 20 diseases related to Alcoholic Cardiomyopathy:



Diseases related to Alcoholic Cardiomyopathy

Symptoms & Phenotypes for Alcoholic Cardiomyopathy

MGI Mouse Phenotypes related to Alcoholic Cardiomyopathy:

44
id Description MGI Source Accession Score Top Affiliating Genes
1 cardiovascular system MP:0005385 9.86 SOAT2 ACADM ACE CYP2E1 MSTN PPARA
2 homeostasis/metabolism MP:0005376 9.76 ACADM ACE ALDH2 CYP2E1 MSTN PPARA
3 adipose tissue MP:0005375 9.62 ACE MSTN PPARA PPARG
4 liver/biliary system MP:0005370 9.56 ACADM ACE ALDH2 CYP2E1 MSTN PPARA
5 neoplasm MP:0002006 8.92 ACE ALDH2 CYP2E1 PPARG

Drugs & Therapeutics for Alcoholic Cardiomyopathy

Drugs for Alcoholic Cardiomyopathy (from DrugBank, HMDB, Dgidb, PharmGKB, IUPHAR, NovoSeek, BitterDB):

(show all 11)
id Name Status Phase Clinical Trials Cas Number PubChem Id
1
Spironolactone Approved Phase 4 1952-01-7, 52-01-7 5833
2 diuretics Phase 4
3 Mineralocorticoid Receptor Antagonists Phase 4
4 Mineralocorticoids Phase 4
5 Natriuretic Agents Phase 4
6 Hormone Antagonists Phase 4
7 Hormones Phase 4
8 Diuretics, Potassium Sparing Phase 4
9 Hormones, Hormone Substitutes, and Hormone Antagonists Phase 4
10 Liver Extracts
11 Antioxidants

Interventional clinical trials:


id Name Status NCT ID Phase Drugs
1 Clinical Trial Studying the Effects of Spironolactone on Heart and Skeletal Muscle Function in Chronic Alcoholics Suspended NCT00226109 Phase 4 spironolactone
2 Prospective Analysis Of Cardiac Function In Cirrhotic Patients By Echocardiography And Its Correlation With Events Unknown status NCT01433848
3 Subclinical Myocardial Dysfunction in Patients With Hepatic Cirrhosis Completed NCT01713478
4 Adapted Physical Activity Effect on Aerobic Function and in Patients in Pre Liver Transplantation Recruiting NCT02567591

Search NIH Clinical Center for Alcoholic Cardiomyopathy

Cochrane evidence based reviews: cardiomyopathy, alcoholic

Genetic Tests for Alcoholic Cardiomyopathy

Anatomical Context for Alcoholic Cardiomyopathy

MalaCards organs/tissues related to Alcoholic Cardiomyopathy:

39
Heart, Liver, Skeletal Muscle

Publications for Alcoholic Cardiomyopathy

Articles related to Alcoholic Cardiomyopathy:

(show top 50) (show all 149)
id Title Authors Year
1
Incidental finding of single coronary artery in a patient with alcoholic cardiomyopathy presenting as acute heart failure. ( 28126699 )
2017
2
Etiology of alcoholic cardiomyopathy: Mitochondria, oxidative stress and apoptosis. ( 28606389 )
2017
3
Alcoholic Cardiomyopathy: Translation Model. ( 28948557 )
2017
4
Alcoholic Cardiomyopathy: Disrupted Protein Balance and Impaired Cardiomyocyte Contractility. ( 28425109 )
2017
5
Alcoholic cardiomyopathy: What is known and what is not known. ( 28647343 )
2017
6
Enzymes and signal pathways in the pathogenesis of alcoholic cardiomyopathy. ( 27418001 )
2016
7
NOX2 amplifies acetaldehyde-mediated cardiomyocyte mitochondrial dysfunction in alcoholic cardiomyopathy. ( 27624556 )
2016
8
Perioperative detection of alcoholic cardiomyopathy: cases and recommendations. ( 27720475 )
2016
9
Alcoholic cardiomyopathy : The result of dosage and individual predisposition. ( 27582365 )
2016
10
Left Ventricular Strain and Rotation by 2-D Speckle Tracking Echocardiography Identify Early Alcoholic Cardiomyopathy. ( 27156014 )
2016
11
Natural history and prognostic factors in alcoholic cardiomyopathy. ( 25458176 )
2015
12
Investigation of microRNA Expression Profiles Associated with Human Alcoholic Cardiomyopathy. ( 25791397 )
2015
13
Malignant ventricular arrhythmias in alcoholic cardiomyopathy. ( 26188828 )
2015
14
A case of heart failure due to alcoholic cardiomyopathy combined with acute pulmonary embolism. ( 25276392 )
2014
15
Alcoholic Cardiomyopathy: Multigenic Changes Underlie Cardiovascular Dysfunction. ( 26478905 )
2014
16
Alcoholic cardiomyopathy: pathophysiologic insights. ( 24671642 )
2014
17
Alcoholic cardiomyopathy. ( 25228956 )
2014
18
Alcoholic cardiomyopathy and cardiovascular events - an insight from the Liptov region. ( 23731046 )
2013
19
Alcoholic cardiomyopathy. ( 24155001 )
2013
20
Quadri-chamber cardiac thrombi in alcoholic cardiomyopathy: a rare though ominous finding. ( 23708237 )
2013
21
Sensitization to cross-reactive carbohydrate determinants in 2 patients with Hymenoptera venom allergy and alcoholic cardiomyopathy. ( 22901863 )
2012
22
Chronic alcohol intake-induced oxidative stress and apoptosis: role of CYP2E1 and calpain-1 in alcoholic cardiomyopathy. ( 21833537 )
2012
23
Evaluation of myocyte proliferation in alcoholic cardiomyopathy: telomerase enzyme activity (TERT) compared with Ki-67 expression. ( 21733836 )
2011
24
Alcoholic cardiomyopathy: a review. ( 21962423 )
2011
25
Increased myostatin activity and decreased myocyte proliferation in chronic alcoholic cardiomyopathy. ( 21463333 )
2011
26
With computed tomography confirmed anterolateral left ventricular pseudoaneurysm in patient with dilatative alcoholic cardiomyopathy. ( 22933953 )
2011
27
Functional proteomic analysis reveals sex-dependent differences in structural and energy-producing myocardial proteins in rat model of alcoholic cardiomyopathy. ( 21245415 )
2011
28
A dilated alcoholic cardiomyopathy. ( 19324436 )
2011
29
Tenascin-x facilitates myocardial fibrosis and cardiac remodeling through transforming growth factor-I^1 and peroxisome proliferator-activated receptor I^ in alcoholic cardiomyopathy. ( 21362339 )
2011
30
Dilated alcoholic cardiomyopathy and incidental lymphoma occuring in a 56 year old man who was being managed for hypertensive heart disease in Enugu Nigeria--a rare finding. ( 22288332 )
2011
31
Carnitine regulates myocardial metabolism by Peroxisome Proliferator-Activated Receptor-alpha (PPARalpha) in alcoholic cardiomyopathy. ( 21169901 )
2011
32
WITHDRAWN: Oxidative stress-induced apoptosis is mediated by calpains in alcoholic cardiomyopathy. ( 21172724 )
2010
33
Alcoholic cardiomyopathy. ( 20308914 )
2010
34
Anticardiolipin antibodies associated with alcoholic cardiomyopathy. ( 18666184 )
2009
35
Diving-related pulmonary oedema as an unusual presentation of alcoholic cardiomyopathy. ( 22692709 )
2008
36
Alcoholic cardiomyopathy: acetaldehyde, insulin insensitization and ER stress. ( 18479704 )
2008
37
[L-carnitine and cardiac metabolism and remodeling indices in alcoholic cardiomyopathy]. ( 19080238 )
2008
38
Expression of renin-angiotensin system and peroxisome proliferator-activated receptors in alcoholic cardiomyopathy. ( 18783396 )
2008
39
Acetaldehyde and alcoholic cardiomyopathy: lessons from the ADH and ALDH2 transgenic models. ( 17590987 )
2007
40
Scintigraphic evaluation of cardiac metabolism and sympathetic nerve function in alcoholic cardiomyopathy. ( 16679703 )
2006
41
Evidence of apoptosis in alcoholic cardiomyopathy. ( 16867874 )
2006
42
Angiotensin II type 1 receptor blockade prevents alcoholic cardiomyopathy. ( 16831986 )
2006
43
Pregnancy outcome in a mother with alcoholic cardiomyopathy. ( 16029303 )
2005
44
A murine model of alcoholic cardiomyopathy: a role for zinc and metallothionein in fibrosis. ( 16049317 )
2005
45
Ethanol and acetaldehyde in alcoholic cardiomyopathy: from bad to ugly en route to oxidative stress. ( 15282111 )
2004
46
Alcoholic cardiomyopathy and ventricular arrhythmias. ( 12684336 )
2003
47
Experimental Assessment of the Role of Acetaldehyde in Alcoholic Cardiomyopathy. ( 12734561 )
2003
48
Gender differences in alcoholic cardiomyopathy. ( 11859686 )
2002
49
Angiotensin-converting enzyme gene polymorphism is associated with vulnerability to alcoholic cardiomyopathy. ( 12204015 )
2002
50
Alcoholic cardiomyopathy: is it dose-dependent? ( 12461319 )
2002

Variations for Alcoholic Cardiomyopathy

Expression for Alcoholic Cardiomyopathy

Search GEO for disease gene expression data for Alcoholic Cardiomyopathy.

Pathways for Alcoholic Cardiomyopathy

Pathways related to Alcoholic Cardiomyopathy according to GeneCards Suite gene sharing:

id Super pathways Score Top Affiliating Genes
1 10.99 ACADM PPARA PPARG
2
Show member pathways
10.79 ACADM ALDH2
3 10.57 ACADM PPARA
4 10.34 CYP2E1 PPARA PPARG

GO Terms for Alcoholic Cardiomyopathy

Biological processes related to Alcoholic Cardiomyopathy according to GeneCards Suite gene sharing:

(show all 17)
id Name GO ID Score Top Affiliating Genes
1 lipid metabolic process GO:0006629 9.73 ACADM PPARA PPARG SOAT2
2 heart development GO:0007507 9.65 ACADM PPARA PPARG
3 regulation of blood pressure GO:0008217 9.57 ACE PPARG
4 response to estrogen GO:0043627 9.56 MSTN PPARG
5 steroid hormone mediated signaling pathway GO:0043401 9.54 PPARA PPARG
6 regulation of lipid metabolic process GO:0019216 9.54 ACADM PPARA PPARG
7 regulation of circadian rhythm GO:0042752 9.52 PPARA PPARG
8 intracellular receptor signaling pathway GO:0030522 9.51 PPARA PPARG
9 response to cold GO:0009409 9.49 ACADM PPARG
10 response to starvation GO:0042594 9.46 ACADM PPARG
11 negative regulation of macrophage derived foam cell differentiation GO:0010745 9.4 PPARA PPARG
12 macrophage derived foam cell differentiation GO:0010742 9.32 PPARG SOAT2
13 negative regulation of cholesterol storage GO:0010887 9.26 PPARA PPARG
14 negative regulation of protein binding GO:0032091 9.25 PPARA
15 positive regulation of fatty acid oxidation GO:0046321 9.16 PPARA PPARG
16 negative regulation of sequestering of triglyceride GO:0010891 8.96 PPARA PPARG
17 negative regulation of receptor biosynthetic process GO:0010871 8.62 PPARA PPARG

Molecular functions related to Alcoholic Cardiomyopathy according to GeneCards Suite gene sharing:

id Name GO ID Score Top Affiliating Genes
1 steroid hormone receptor activity GO:0003707 9.16 PPARA PPARG
2 RNA polymerase II transcription factor activity, ligand-activated sequence-specific DNA binding GO:0004879 8.96 PPARA PPARG
3 drug binding GO:0008144 8.8 ACE PPARA PPARG

Sources for Alcoholic Cardiomyopathy

3 CDC
7 CNVD
9 Cosmic
10 dbSNP
11 DGIdb
16 ExPASy
18 FMA
28 GO
29 GTR
30 HGMD
31 HMDB
32 HPO
33 ICD10
34 ICD10 via Orphanet
35 ICD9CM
36 IUPHAR
37 KEGG
38 LifeMap
40 MedGen
42 MeSH
43 MESH via Orphanet
44 MGI
46 NCI
47 NCIt
48 NDF-RT
51 NINDS
52 Novoseek
54 OMIM
55 OMIM via Orphanet
59 PubMed
60 QIAGEN
65 SNOMED-CT via HPO
66 SNOMED-CT via Orphanet
67 TGDB
68 Tocris
69 UMLS
70 UMLS via Orphanet
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