MCID: ALC010
MIFTS: 49

Alcoholic Cardiomyopathy malady

Cardiovascular diseases, Muscle diseases categories
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Summaries for Alcoholic Cardiomyopathy

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Wikipedia:65 Alcoholic cardiomyopathy is a disease in which the chronic long-term abuse of alcohol (i.e. ethanol)... more...

MalaCards based summary: Alcoholic Cardiomyopathy, also known as dilated cardiomyopathy secondary to alcohol, is related to hypertensive heart disease and hypertension. An important gene associated with Alcoholic Cardiomyopathy is MSTN (myostatin), and among its related pathways are Regulation of Cholesterol Biosynthesis by SREBP (SREBF) and Adipogenesis. The compounds beta blocking agents and tzd18 have been mentioned in the context of this disorder. Affiliated tissues include heart and liver, and related mouse phenotypes are muscle and adipose tissue.

Aliases & Classifications for Alcoholic Cardiomyopathy

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Alcoholic Cardiomyopathy, Aliases & Descriptions:

Name: Alcoholic Cardiomyopathy 8
Dilated Cardiomyopathy Secondary to Alcohol 8
 
Alcohol-Induced Heart Muscle Disease 8
Cardiomyopathy, Alcoholic 62


Classifications:

Malacards categories (disease lists): (See all malacards categories)
Anatomical: Cardiovascular diseases, Muscle diseases


External Ids:

Disease Ontology8 DOID:12935
MeSH34 D002310
NCIt39 C53653
SNOMED-CT57 155352001, 83521008
ICD9CM27 425.5
ICD1025 I42.6

Related Diseases for Alcoholic Cardiomyopathy

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Diseases related to Alcoholic Cardiomyopathy via text searches within MalaCards or GeneCards/GeneDecks gene sharing:

(show all 41)
idRelated DiseaseScoreTop Affiliating Genes
1hypertensive heart disease30.2PPARA, ACE
2hypertension29.9PPARG, PPARA, ACE
3retinal artery occlusion10.4APOH
4hypoalphalipoproteinemia10.4PPARA
5cerebrovascular disease10.2ACE, APOH
6non-suppurative otitis media10.1PPARA, MSTN
7nephritis10.1ACE, APOH
8hypercholesterolemia10.0ACE, PPARA
9liver disease10.0
10hypersplenism10.0
11artery disease10.0
12myocarditis10.0
13myopathy10.0
14pulmonary embolism10.0
15systemic scleroderma10.0ACE, APOH
16proteinuria10.0APOH, ACE
17congenital heart disease10.0PPARA, ACE
18tangier disease10.0PPARA, PPARG
19liposarcoma10.0PPARA, PPARG
20lipodystrophy10.0PPARG, PPARA
21glucose intolerance10.0PPARA, PPARG
22fatty liver disease10.0PPARA, PPARG
23hypertriglyceridemia9.9PPARG, PPARA
24polycystic ovary syndrome9.9PPARA, PPARG
25alzheimer's disease9.9PPARA, PPARG
26noonan syndrome9.9ACADM, ACE
27familial adenomatous polyposis9.9PPARG, PPARA
28idiopathic edema9.8PPARA, PPARG, ACE
29hyperinsulinism9.8PPARA, PPARG
30familial hyperlipidemia9.8PPARA, ACE, PPARG
31obesity9.8MSTN, PPARA, PPARG
32diabetic nephropathy9.8ACE, PPARG, PPARA
33hyperglycemia9.8ACE, PPARA, PPARG
34coronary artery anomaly9.8PPARA, PPARG, ACE
35type 2 diabetes mellitus9.8ACE, PPARA, PPARG
36primary hyperoxaluria9.8PPARA, PPARG, ACE
37diabetes mellitus9.7PPARG, ACE, PPARA
38metabolic syndrome x9.6MSTN, PPARA, PPARG, ACADM
39insulin resistance9.6MSTN, ACE, PPARA, PPARG
40vascular disease9.6PPARA, PPARG, APOH, ACE
41atherosclerosis9.6PPARG, PPARA, APOH, ACE

Graphical network of the top 20 diseases related to Alcoholic Cardiomyopathy:



Diseases related to alcoholic cardiomyopathy

Symptoms for Alcoholic Cardiomyopathy

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Drugs & Therapeutics for Alcoholic Cardiomyopathy

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Drug clinical trials:

Search ClinicalTrials for Alcoholic Cardiomyopathy

Search NIH Clinical Center for Alcoholic Cardiomyopathy

Genetic Tests for Alcoholic Cardiomyopathy

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Anatomical Context for Alcoholic Cardiomyopathy

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MalaCards organs/tissues related to Alcoholic Cardiomyopathy:

32
Heart, Liver

Animal Models for Alcoholic Cardiomyopathy or affiliated genes

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MGI Mouse Phenotypes related to Alcoholic Cardiomyopathy:

36
idDescriptionMGI Source AccessionScoreTop Affiliating Genes
1MP:00053698.2PPARA, MSTN, ACADM, PPARG
2MP:00053758.0PPARG, PPARA, MSTN, ACE
3MP:00053707.8PPARG, PPARA, MSTN, ACADM, ACE
4MP:00053857.3PPARG, ACE, ACADM, MSTN, PPARA
5MP:00053767.2ACADM, MSTN, APOH, PPARA, PPARG, ACE
6MP:00107687.1ACE, PPARG, PPARA, APOH, MSTN, ACADM

Publications for Alcoholic Cardiomyopathy

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Articles related to Alcoholic Cardiomyopathy:

(show top 50)    (show all 134)
idTitleAuthorsYear
1
Alcoholic cardiomyopathy. (24155001)
2013
2
Alcoholic cardiomyopathy and cardiovascular events - an insight from the Liptov region. (23731046)
2013
3
Sensitization to cross-reactive carbohydrate determinants in 2 patients with Hymenoptera venom allergy and alcoholic cardiomyopathy. (22901863)
2012
4
Alcoholic cardiomyopathy: a review. (21962423)
2011
5
Increased myostatin activity and decreased myocyte proliferation in chronic alcoholic cardiomyopathy. (21463333)
2011
6
Functional proteomic analysis reveals sex-dependent differences in structural and energy-producing myocardial proteins in rat model of alcoholic cardiomyopathy. (21245415)
2011
7
Carnitine regulates myocardial metabolism by Peroxisome Proliferator-Activated Receptor-alpha (PPARalpha) in alcoholic cardiomyopathy. (21169901)
2011
8
Tenascin-x facilitates myocardial fibrosis and cardiac remodeling through transforming growth factor-I^1 and peroxisome proliferator-activated receptor I^ in alcoholic cardiomyopathy. (21362339)
2011
9
Evaluation of myocyte proliferation in alcoholic cardiomyopathy: telomerase enzyme activity (TERT) compared with Ki-67 expression. (21733836)
2011
10
With computed tomography confirmed anterolateral left ventricular pseudoaneurysm in patient with dilatative alcoholic cardiomyopathy. (22933953)
2011
11
Anticardiolipin antibodies associated with alcoholic cardiomyopathy. (18666184)
2009
12
Alcoholic cardiomyopathy: acetaldehyde, insulin insensitization and ER stress. (18479704)
2008
13
L-carnitine and cardiac metabolism and remodeling indices in alcoholic cardiomyopathy]. (19080238)
2008
14
Scintigraphic evaluation of cardiac metabolism and sympathetic nerve function in alcoholic cardiomyopathy. (16679703)
2006
15
Ethanol and acetaldehyde in alcoholic cardiomyopathy: from bad to ugly en route to oxidative stress. (15282111)
2004
16
Experimental Assessment of the Role of Acetaldehyde in Alcoholic Cardiomyopathy. (12734561)
2003
17
Gender differences in alcoholic cardiomyopathy. (11859686)
2002
18
A transgenic model of acetaldehyde overproduction accelerates alcohol cardiomyopathy. (10525098)
1999
19
Alcoholic cardiomyopathy: is outcome linked to stimulus withdrawal? (8732367)
1996
20
Alcoholic cardiomyopathy in rats: inotropic responses to phenylephrine, glucagon, ouabain, and dobutamine. (3437459)
1987
21
Alcoholic cardiomyopathy and sudden cardiac death. (3711541)
1986
22
Regression of severe alcoholic cardiomyopathy after abstinence of 10 weeks. (3530014)
1986
23
Effect of chronic ethanol ingestion on the metabolism of copper, iron, manganese, selenium, and zinc in an animal model of alcoholic cardiomyopathy. (6502742)
1984
24
Improvement of left ventricular function in alcoholic cardiomyopathy documented by serial gated cardiac pool scanning. (292382)
1979
25
Pulsus alternans induced by glyceryl trinitrate paste in a patient with alcoholic cardiomyopathy. (154916)
1979
26
Alcoholic cardiomyopathy. (884942)
1977
27
Alcoholic cardiomyopathy. (890189)
1977
28
The small coronary arteries in alcoholic cardiomyopathy. (910681)
1977
29
Alcohol and the heart: alcoholic cardiomyopathy. (926061)
1977
30
Alcoholic cardiomyopathy: a nursing approach. (243794)
1977
31
Alcoholic cardiomyopathy in mice. Myocardial glycogen, lipids and certain enzymes. (17013)
1977
32
Reversibility of alcoholic cardiomyopathy. II. Role of atrial fibrillation. (983967)
1976
33
Alcoholic cardiomyopathy: the effect of ethanol and acetaldehyde on cardiac protein synthesis. (1241620)
1975
34
Editorial: Alcoholic cardiomyopathy. (4441876)
1974
35
The incidence of myocardial abnormalities in man related to the level of ethanol consumption. A proposal of a diagnostic criterion of alcoholic cardiomyopathy. (4140250)
1974
36
Letter: Alcoholic cardiomyopathy. (4277554)
1974
37
Alcoholic cardiomyopathy. II. The inhibition of cardiac microsomal protein synthesis by acetaldehyde. (4828692)
1974
38
Heart block in alcoholic cardiomyopathy. (4413642)
1974
39
Alcoholic cardiomyopathy: an introductory review. (4550483)
1972
40
Alcoholic cardiomyopathy. (4944526)
1971
41
Alcoholic cardiomyopathy managed with prolonged bed rest. (4254303)
1971
42
Alcoholic cardiomyopathy. Concept of the disease and its treatment. (4925694)
1971
43
Alcoholic cardiomyopathy: a critical review. (4921395)
1970
44
Alcoholic cardiomyopathy. (5706476)
1968
45
Alcoholic cardiomyopathy. (4166114)
1967
46
Alcoholic cardiomyopathy. (6051265)
1967
47
ALCOHOLIC CARDIOMYOPATHY; A HISTOCHEMICAL STUDY. (14296641)
1965
48
ALCOHOLIC CARDIOMYOPATHY. (14317452)
1965
49
Alcoholic cardiomyopathy. (14447338)
1961
50
Alcoholic cardiomyopathy in a man with Gaustad's syndrome. (13586663)
1958

Variations for Alcoholic Cardiomyopathy

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Expression for genes affiliated with Alcoholic Cardiomyopathy

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Expression patterns in normal tissues for genes affiliated with Alcoholic Cardiomyopathy

Search GEO for disease gene expression data for Alcoholic Cardiomyopathy.

Pathways for genes affiliated with Alcoholic Cardiomyopathy

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Compounds for genes affiliated with Alcoholic Cardiomyopathy

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Compounds related to Alcoholic Cardiomyopathy according to GeneCards/GeneDecks:

(show top 50)    (show all 118)
idCompoundScoreTop Affiliating Genes
1beta blocking agents509.7ACE, PPARA
2tzd18289.5PPARG, PPARA
3gw409544289.5PPARA, PPARG
4mk-0767289.5PPARA, PPARG
5gi262570449.5PPARG, PPARA
6ragaglitazar44 2810.5PPARA, PPARG
7gw 1929449.5PPARA, PPARG
8mono(2-ethylhexyl)phthalate449.5PPARA, PPARG
9ly-510929289.5PPARA, PPARG
10ad-5061289.4PPARG, PPARA
11reglitazar289.4PPARG, PPARA
12farglitazar289.4PPARG, PPARA
13ly-465608289.4PPARG, PPARA
14bisphenol a diglycidyl ether449.4PPARG, PPARA
15tetradecylthioacetic acid449.4PPARG, PPARA
16gw 764744 6110.4PPARA, PPARG
17gw9578289.4PPARA, PPARG
18gw50151644 2810.4PPARA, PPARG
19prostaglandin j2449.4PPARA, PPARG
20tesaglitazar449.4PPARG, PPARA
21octanoate449.0ACADM, PPARA, PPARG
22telmisartan44 28 1111.0PPARA, PPARG, ACE
23carnitine448.9PPARA, PPARG, ACADM
24Lauroyl-CoA248.9PPARA, ACADM, PPARG
25Isovaleryl-CoA248.9PPARG, PPARA, ACADM
26metformin44 50 1110.9ACE, PPARA, PPARG
27Isobutyryl-CoA248.9PPARG, PPARA, ACADM
28Glutaconyl-CoA248.9PPARA, PPARG, ACADM
29Hexanoyl-CoA248.9ACADM, PPARA, PPARG
30Nonanoyl-CoA248.9ACADM, PPARA, PPARG
31Undecanoyl-CoA248.9PPARA, ACADM, PPARG
32pravastatin44 50 28 24 1112.9ACE, PPARA, PPARG
33trans-Octadec-2-enoyl-CoA248.8PPARG, ACADM, PPARA
34Tetracosanoyl-CoA248.8PPARG, PPARA, ACADM
35Pentanoyl-CoA248.8PPARG, PPARA, ACADM
362-Methylhexanoyl-CoA248.8ACADM, PPARG, PPARA
372-methylbutyryl-coa44 249.8ACADM, PPARA, PPARG
38Butyryl-CoA248.8ACADM, PPARA, PPARG
39Decanoyl-CoA (n-C10:0CoA)248.7ACADM, PPARA, PPARG
40octanoyl-coa44 249.7ACADM, PPARA, PPARG
41Eicosanoyl-CoA248.6PPARG, PPARA, ACADM
423Z-dodecenoyl-CoA248.6ACADM, PPARG, PPARA
43(2E)-Dodecenoyl-CoA248.6ACADM, PPARA, PPARG
44(2E)-Octenoyl-CoA248.5ACADM, PPARA, PPARG
45prostacyclin448.4PPARG, APOH, PPARA, ACE
46aspirin44 50 28 2411.4PPARA, ACE, APOH, PPARG
47fatty acid448.4ACADM, APOH, PPARA, PPARG
48(2E)-Decenoyl-CoA248.3ACADM, PPARA, PPARG
49lipid447.9APOH, PPARA, ACADM, PPARG, ACE
50glucose447.6MSTN, APOH, PPARG, ACADM, ACE, PPARA

GO Terms for genes affiliated with Alcoholic Cardiomyopathy

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Biological processes related to Alcoholic Cardiomyopathy according to GeneCards/GeneDecks:

(show all 10)
idNameGO IDScoreTop Affiliating Genes
1response to coldGO:0094099.3PPARG, ACADM
2negative regulation of receptor biosynthetic processGO:0108719.3PPARG, PPARA
3response to estrogenGO:0436279.2PPARG, MSTN
4positive regulation of fatty acid oxidationGO:0463219.2PPARG, PPARA
5negative regulation of sequestering of triglycerideGO:0108919.2PPARG, PPARA
6negative regulation of cholesterol storageGO:0108879.2PPARG, PPARA
7negative regulation of macrophage derived foam cell differentiationGO:0107459.1PPARG, PPARA
8regulation of blood pressureGO:0082179.0ACE, PPARG
9lipid metabolic processGO:0066299.0PPARG, PPARA
10positive regulation of transcription, DNA-templatedGO:0458938.3MSTN, PPARA, PPARG

Molecular functions related to Alcoholic Cardiomyopathy according to GeneCards/GeneDecks:

idNameGO IDScoreTop Affiliating Genes
1heparin bindingGO:0082019.5MSTN, APOH
2ligand-activated sequence-specific DNA binding RNA polymerase II transcription factor activityGO:0048799.1PPARA, PPARG
3lipid bindingGO:0082899.0APOH, PPARA
4steroid hormone receptor activityGO:0037079.0PPARA, PPARG
5identical protein bindingGO:0428029.0APOH, MSTN, ACADM
6drug bindingGO:0081448.6ACE, PPARA, PPARG

Products for genes affiliated with Alcoholic Cardiomyopathy

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  • Antibodies
  • Proteins
  • Lysates

Sources for Alcoholic Cardiomyopathy

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3CDC
13ExPASy
14FMA
22GTR
23HGMD
24HMDB
25ICD10
26ICD10 via Orphanet
27ICD9CM
28IUPHAR
29KEGG
34MeSH
35MESH via Orphanet
36MGI
39NCIt
40NDF-RT
43NINDS
44Novoseek
46OMIM
47OMIM via Orphanet
51PubMed
52QIAGEN
58SNOMED-CT via Orphanet
62UMLS
63UMLS via Orphanet