MCID: ALC010
MIFTS: 38

Alcoholic Cardiomyopathy

Categories: Cardiovascular diseases

Aliases & Classifications for Alcoholic Cardiomyopathy

MalaCards integrated aliases for Alcoholic Cardiomyopathy:

Name: Alcoholic Cardiomyopathy 12 14
Cardiomyopathy, Alcoholic 41 69
Dilated Cardiomyopathy Secondary to Alcohol 12
Alcohol-Induced Heart Muscle Disease 12

Classifications:



External Ids:

Disease Ontology 12 DOID:12935
ICD10 32 I42.6
ICD9CM 34 425.5
MeSH 41 D002310
NCIt 46 C53653
SNOMED-CT 64 155352001 83521008
UMLS 69 C0007192

Summaries for Alcoholic Cardiomyopathy

MalaCards based summary : Alcoholic Cardiomyopathy, also known as cardiomyopathy, alcoholic, is related to idiopathic edema and lipid metabolism disorder. An important gene associated with Alcoholic Cardiomyopathy is PPARA (Peroxisome Proliferator Activated Receptor Alpha), and among its related pathways/superpathways are Nuclear Receptors in Lipid Metabolism and Toxicity and beta-Alanine metabolism (KEGG). The drugs Spironolactone and diuretics have been mentioned in the context of this disorder. Affiliated tissues include heart and liver, and related phenotypes are cardiovascular system and adipose tissue

Wikipedia : 72 Alcoholic cardiomyopathy is a disease in which the chronic long-term abuse of alcohol (i.e., ethanol)... more...

Related Diseases for Alcoholic Cardiomyopathy

Graphical network of the top 20 diseases related to Alcoholic Cardiomyopathy:



Diseases related to Alcoholic Cardiomyopathy

Symptoms & Phenotypes for Alcoholic Cardiomyopathy

MGI Mouse Phenotypes related to Alcoholic Cardiomyopathy:

43
# Description MGI Source Accession Score Top Affiliating Genes
1 cardiovascular system MP:0005385 9.76 ACADM ACE CDK9 MSTN PPARA PPARG
2 adipose tissue MP:0005375 9.56 ACE MSTN PPARA PPARG
3 homeostasis/metabolism MP:0005376 9.5 ACE ALDH2 MSTN PPARA PPARG SOAT2
4 liver/biliary system MP:0005370 9.17 ACADM ACE ALDH2 MSTN PPARA PPARG

Drugs & Therapeutics for Alcoholic Cardiomyopathy

Drugs for Alcoholic Cardiomyopathy (from DrugBank, HMDB, Dgidb, PharmGKB, IUPHAR, NovoSeek, BitterDB):

(show all 10)
# Name Status Phase Clinical Trials Cas Number PubChem Id
1
Spironolactone Approved Phase 4 1952-01-7, 52-01-7 5833
2 diuretics Phase 4
3 Diuretics, Potassium Sparing Phase 4
4 Hormone Antagonists Phase 4
5 Hormones Phase 4
6 Hormones, Hormone Substitutes, and Hormone Antagonists Phase 4
7 Mineralocorticoid Receptor Antagonists Phase 4
8 Mineralocorticoids Phase 4
9 Natriuretic Agents Phase 4
10 Liver Extracts

Interventional clinical trials:


# Name Status NCT ID Phase Drugs
1 Clinical Trial Studying the Effects of Spironolactone on Heart and Skeletal Muscle Function in Chronic Alcoholics Suspended NCT00226109 Phase 4 spironolactone
2 Adapted Physical Activity Effect on Aerobic Function and in Patients in Pre Liver Transplantation Recruiting NCT02567591

Search NIH Clinical Center for Alcoholic Cardiomyopathy

Cochrane evidence based reviews: cardiomyopathy, alcoholic

Genetic Tests for Alcoholic Cardiomyopathy

Anatomical Context for Alcoholic Cardiomyopathy

MalaCards organs/tissues related to Alcoholic Cardiomyopathy:

38
Heart, Liver

Publications for Alcoholic Cardiomyopathy

Articles related to Alcoholic Cardiomyopathy:

(show top 50) (show all 154)
# Title Authors Year
1
Re: Left Ventricular Strain and Rotation by 2-D Speckle Tracking Echocardiography Identify Early Alcoholic Cardiomyopathy. ( 29033096 )
2018
2
Alcoholic cardiomyopathy: What is known and what is not known. ( 28647343 )
2017
3
Therapeutic effects of rapamycin on alcoholic cardiomyopathy. ( 28966668 )
2017
4
Extracorporeal membrane oxygenation for cardiogenic shock due to alcoholic cardiomyopathy: a long-term follow-up of 4 cases. ( 29281011 )
2017
5
Alcoholic Cardiomyopathy: Disrupted Protein Balance and Impaired Cardiomyocyte Contractility. ( 28425109 )
2017
6
From the Cover: Alcohol Inhibition of the Enzymatic Activity of Glyceraldehyde 3-Phosphate Dehydrogenase Impairs Cardiac Glucose Utilization, Contributing to Alcoholic Cardiomyopathy. ( 28962519 )
2017
7
Hydrogen sulfide alleviates myocardial fibrosis in mice with alcoholic cardiomyopathy by downregulating autophagy. ( 29039471 )
2017
8
Incidental finding of single coronary artery in a patient with alcoholic cardiomyopathy presenting as acute heart failure. ( 28126699 )
2017
9
Etiology of alcoholic cardiomyopathy: Mitochondria, oxidative stress and apoptosis. ( 28606389 )
2017
10
Alcoholic Cardiomyopathy: Translation Model. ( 28948557 )
2017
11
Left Ventricular Strain and Rotation by 2-D Speckle Tracking Echocardiography Identify Early Alcoholic Cardiomyopathy. ( 27156014 )
2016
12
Alcoholic cardiomyopathy : The result of dosage and individual predisposition. ( 27582365 )
2016
13
Perioperative detection of alcoholic cardiomyopathy: cases and recommendations. ( 27720475 )
2016
14
Enzymes and signal pathways in the pathogenesis of alcoholic cardiomyopathy. ( 27418001 )
2016
15
NOX2 amplifies acetaldehyde-mediated cardiomyocyte mitochondrial dysfunction in alcoholic cardiomyopathy. ( 27624556 )
2016
16
Investigation of microRNA Expression Profiles Associated with Human Alcoholic Cardiomyopathy. ( 25791397 )
2015
17
Malignant ventricular arrhythmias in alcoholic cardiomyopathy. ( 26188828 )
2015
18
Natural history and prognostic factors in alcoholic cardiomyopathy. ( 25458176 )
2015
19
Alcoholic cardiomyopathy. ( 25228956 )
2014
20
Alcoholic cardiomyopathy: pathophysiologic insights. ( 24671642 )
2014
21
A case of heart failure due to alcoholic cardiomyopathy combined with acute pulmonary embolism. ( 25276392 )
2014
22
Alcoholic Cardiomyopathy: Multigenic Changes Underlie Cardiovascular Dysfunction. ( 26478905 )
2014
23
Alcoholic cardiomyopathy and cardiovascular events - an insight from the Liptov region. ( 23731046 )
2013
24
Quadri-chamber cardiac thrombi in alcoholic cardiomyopathy: a rare though ominous finding. ( 23708237 )
2013
25
Alcoholic cardiomyopathy. ( 24155001 )
2013
26
Chronic alcohol intake-induced oxidative stress and apoptosis: role of CYP2E1 and calpain-1 in alcoholic cardiomyopathy. ( 21833537 )
2012
27
Sensitization to cross-reactive carbohydrate determinants in 2 patients with Hymenoptera venom allergy and alcoholic cardiomyopathy. ( 22901863 )
2012
28
Evaluation of myocyte proliferation in alcoholic cardiomyopathy: telomerase enzyme activity (TERT) compared with Ki-67 expression. ( 21733836 )
2011
29
Carnitine regulates myocardial metabolism by Peroxisome Proliferator-Activated Receptor-alpha (PPARalpha) in alcoholic cardiomyopathy. ( 21169901 )
2011
30
Functional proteomic analysis reveals sex-dependent differences in structural and energy-producing myocardial proteins in rat model of alcoholic cardiomyopathy. ( 21245415 )
2011
31
With computed tomography confirmed anterolateral left ventricular pseudoaneurysm in patient with dilatative alcoholic cardiomyopathy. ( 22933953 )
2011
32
Tenascin-x facilitates myocardial fibrosis and cardiac remodeling through transforming growth factor-I^1 and peroxisome proliferator-activated receptor I^ in alcoholic cardiomyopathy. ( 21362339 )
2011
33
Dilated alcoholic cardiomyopathy and incidental lymphoma occuring in a 56 year old man who was being managed for hypertensive heart disease in Enugu Nigeria--a rare finding. ( 22288332 )
2011
34
A dilated alcoholic cardiomyopathy. ( 19324436 )
2011
35
Alcoholic cardiomyopathy: a review. ( 21962423 )
2011
36
Increased myostatin activity and decreased myocyte proliferation in chronic alcoholic cardiomyopathy. ( 21463333 )
2011
37
Alcoholic cardiomyopathy. ( 20308914 )
2010
38
WITHDRAWN: Oxidative stress-induced apoptosis is mediated by calpains in alcoholic cardiomyopathy. ( 21172724 )
2010
39
Anticardiolipin antibodies associated with alcoholic cardiomyopathy. ( 18666184 )
2009
40
Diving-related pulmonary oedema as an unusual presentation of alcoholic cardiomyopathy. ( 22692709 )
2008
41
[L-carnitine and cardiac metabolism and remodeling indices in alcoholic cardiomyopathy]. ( 19080238 )
2008
42
Alcoholic cardiomyopathy: acetaldehyde, insulin insensitization and ER stress. ( 18479704 )
2008
43
Expression of renin-angiotensin system and peroxisome proliferator-activated receptors in alcoholic cardiomyopathy. ( 18783396 )
2008
44
Acetaldehyde and alcoholic cardiomyopathy: lessons from the ADH and ALDH2 transgenic models. ( 17590987 )
2007
45
Scintigraphic evaluation of cardiac metabolism and sympathetic nerve function in alcoholic cardiomyopathy. ( 16679703 )
2006
46
Angiotensin II type 1 receptor blockade prevents alcoholic cardiomyopathy. ( 16831986 )
2006
47
Evidence of apoptosis in alcoholic cardiomyopathy. ( 16867874 )
2006
48
Pregnancy outcome in a mother with alcoholic cardiomyopathy. ( 16029303 )
2005
49
A murine model of alcoholic cardiomyopathy: a role for zinc and metallothionein in fibrosis. ( 16049317 )
2005
50
Ethanol and acetaldehyde in alcoholic cardiomyopathy: from bad to ugly en route to oxidative stress. ( 15282111 )
2004

Variations for Alcoholic Cardiomyopathy

Expression for Alcoholic Cardiomyopathy

Search GEO for disease gene expression data for Alcoholic Cardiomyopathy.

Pathways for Alcoholic Cardiomyopathy

Pathways related to Alcoholic Cardiomyopathy according to GeneCards Suite gene sharing:

# Super pathways Score Top Affiliating Genes
1 10.8 PPARA PPARG
2
Show member pathways
10.69 ACADM ALDH2
3 10.66 ACADM PPARA PPARG
4 10.37 ACADM PPARA

GO Terms for Alcoholic Cardiomyopathy

Biological processes related to Alcoholic Cardiomyopathy according to GeneCards Suite gene sharing:

(show all 17)
# Name GO ID Score Top Affiliating Genes
1 lipid metabolic process GO:0006629 9.73 ACADM PPARA PPARG SOAT2
2 heart development GO:0007507 9.65 ACADM PPARA PPARG
3 transcription initiation from RNA polymerase II promoter GO:0006367 9.63 CDK9 PPARA PPARG
4 regulation of blood pressure GO:0008217 9.57 ACE PPARG
5 response to estrogen GO:0043627 9.56 MSTN PPARG
6 steroid hormone mediated signaling pathway GO:0043401 9.55 PPARA PPARG
7 regulation of circadian rhythm GO:0042752 9.54 PPARA PPARG
8 regulation of lipid metabolic process GO:0019216 9.54 ACADM PPARA PPARG
9 intracellular receptor signaling pathway GO:0030522 9.52 PPARA PPARG
10 response to cold GO:0009409 9.51 ACADM PPARG
11 response to starvation GO:0042594 9.49 ACADM PPARG
12 negative regulation of macrophage derived foam cell differentiation GO:0010745 9.4 PPARA PPARG
13 macrophage derived foam cell differentiation GO:0010742 9.32 PPARG SOAT2
14 negative regulation of cholesterol storage GO:0010887 9.26 PPARA PPARG
15 positive regulation of fatty acid oxidation GO:0046321 9.16 PPARA PPARG
16 negative regulation of sequestering of triglyceride GO:0010891 8.96 PPARA PPARG
17 negative regulation of receptor biosynthetic process GO:0010871 8.62 PPARA PPARG

Molecular functions related to Alcoholic Cardiomyopathy according to GeneCards Suite gene sharing:

# Name GO ID Score Top Affiliating Genes
1 transcription factor binding GO:0008134 9.43 CDK9 PPARA PPARG
2 steroid hormone receptor activity GO:0003707 9.32 PPARA PPARG
3 nuclear receptor activity GO:0004879 9.16 PPARA PPARG
4 transcription coactivator binding GO:0001223 8.96 CDK9 PPARA
5 drug binding GO:0008144 8.8 ACE PPARA PPARG

Sources for Alcoholic Cardiomyopathy

3 CDC
7 CNVD
9 Cosmic
10 dbSNP
11 DGIdb
16 ExPASy
18 FMA
27 GO
28 GTR
29 HGMD
30 HMDB
31 HPO
32 ICD10
33 ICD10 via Orphanet
34 ICD9CM
35 IUPHAR
36 KEGG
37 LifeMap
39 MedGen
41 MeSH
42 MESH via Orphanet
43 MGI
45 NCI
46 NCIt
47 NDF-RT
50 NINDS
51 Novoseek
53 OMIM
54 OMIM via Orphanet
58 PubMed
60 QIAGEN
65 SNOMED-CT via HPO
66 SNOMED-CT via Orphanet
67 TGDB
68 Tocris
69 UMLS
70 UMLS via Orphanet
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