MCID: ALC010
MIFTS: 48

Alcoholic Cardiomyopathy malady

Cardiovascular diseases category

Summaries for Alcoholic Cardiomyopathy

About this section
Sources:
63Wikipedia, 32MalaCards
See all sources

Fully expand this MalaCard

Export this MalaCard
Wikipedia:63 Alcoholic cardiomyopathy is a disease in which the chronic long-term abuse of alcohol (i.e. ethanol)... more...

MalaCards: Alcoholic Cardiomyopathy, also known as dilated cardiomyopathy secondary to alcohol, is related to alcohol dependence and hypertension. An important gene associated with Alcoholic Cardiomyopathy is MSTN (myostatin), and among its related pathways are beta-Alanine metabolism and tryptophan utilization II. The compounds mono(2-ethylhexyl)phthalate and reglitazar have been mentioned in the context of this disorder. Affiliated tissues include heart and liver, and related mouse phenotypes are adipose tissue and tumorigenesis.

Aliases & Classifications for Alcoholic Cardiomyopathy

About this section
Sources:
8Disease Ontology, 60UMLS, 39NCIt, 56SNOMED-CT, 34MeSH, 27ICD9CM, 25ICD10
See all sources

Classifications:

Malacards categories (disease lists): (See all malacards categories)
Anatomical: Cardiovascular diseases


Aliases & Descriptions:

alcoholic cardiomyopathy 8
dilated cardiomyopathy secondary to alcohol 8
alcohol-induced heart muscle disease 8
cardiomyopathy, alcoholic 60


External Ids:

Disease Ontology8 DOID:12935
NCIt39 C53653
MeSH34 D002310
SNOMED-CT56 155352001, 83521008
ICD9CM27 425.5
ICD1025 I42.6

Related Diseases for Alcoholic Cardiomyopathy

About this section
Sources:
17GeneCards, 18GeneDecks
See all sources

Diseases related to Alcoholic Cardiomyopathy via text searches within MalaCards or GeneCards/GeneDecks gene sharing:

(show top 50)    (show all 69)
idRelated DiseaseScoreTop Affiliating Genes
1alcohol dependence30.2ALDH2
2hypertension30.1ACE, PPARG, PPARA
3myopathy29.9MSTN, PPARA
4liver cirrhosis29.9AKR1A1, ALDH2
5hypertensive heart disease29.9PPARA, ACE
6alcoholic liver cirrhosis29.9ALDH2, AKR1A1
7coronary artery disease29.9PPARA, PPARG, ACE
8hypertrophic cardiomyopathy10.3
9dilated cardiomyopathy10.2
10neuropathy10.0MSTN
11hepatitis10.0AKR1A1
12hyperhomocysteinemia10.0APOH
13vascular disease10.0APOH
14stroke, ischemic10.0APOH
15retinal artery occlusion10.0APOH
16cystic fibrosis10.0ACADM
17thromboembolism10.0APOH
18dermatitis10.0PPARA
19rheumatoid arthritis10.0APOH
20acute myocardial infarction10.0ACE
21vasculitis10.0APOH
22fetal alcohol spectrum disorder10.0AKR1A1
23acute pancreatitis10.0ALDH2
24asthma10.0ALDH2
25esophageal cancer10.0ALDH2
26gastritis10.0AKR1A1
27dementia10.0ALDH2
28tuberculosis10.0AKR1A1
29arthritis10.0PPARA
30schizophrenia10.0PPARA
31pancreatitis10.0ALDH2
32migraine10.0APOH
33retinal vein occlusion10.0APOH
34arteriosclerosis10.0PPARG
35sarcoidosis10.0ACE
36hypercholesterolemia10.0PPARA, ACE
37heart lymphoma10.0
38hypersplenism10.0
39liver disease10.0
40myocarditis10.0
41alcoholic pancreatitis10.0ALDH2, AKR1A1
42sudden cardiac death multi-gene panels10.0ACADM, ACE
43hepatitis b10.0ALDH2, PPARA
44squamous cell carcinoma10.0ALDH2
45adenocarcinoma10.0ALDH2, PPARA
46noonan syndrome10.0ACADM, ACE, AKR1A1
47fatty liver disease10.0PPARA, PPARG
48polycystic ovary syndrome10.0PPARG, PPARA
49glucose intolerance10.0PPARA, PPARG
50hypertriglyceridemia10.0PPARG, PPARA

Graphical network of the top 20 diseases related to Alcoholic Cardiomyopathy:



Diseases related to alcoholic cardiomyopathy

Clinical Features for Alcoholic Cardiomyopathy

About this section

Drugs & Therapeutics for Alcoholic Cardiomyopathy

About this section
Sources:
5CenterWatch, 41NIH Clinical Center, 6ClinicalTrials
See all sources

Approved drugs:

Search CenterWatch for Alcoholic Cardiomyopathy

Drug clinical trials:

Search ClinicalTrials for Alcoholic Cardiomyopathy

Search NIH Clinical Center for Alcoholic Cardiomyopathy

Search CenterWatch for Alcoholic Cardiomyopathy

Genetic Tests for Alcoholic Cardiomyopathy

About this section

Anatomical Context for Alcoholic Cardiomyopathy

About this section
Sources:
32MalaCards
See all sources

MalaCards organs/tissues related to Alcoholic Cardiomyopathy:

32
Heart, Liver

Animal Models for Alcoholic Cardiomyopathy or affiliated genes

About this section
Sources:
36MGI
See all sources

MGI Mouse Phenotypes related to Alcoholic Cardiomyopathy:

36
idDescriptionMGI Source AccessionScoreTop Affiliating Genes
1MP:00053758.9MSTN, ACE, PPARA
2MP:00020068.1ALDH2, ACE, PPARG, TNXB
3MP:00053708.0PPARA, PPARG, ACE, ACADM, MSTN
4MP:00053877.1PPARA, PPARG, AKR1A1, ACE, MSTN, ALDH2
5MP:00053846.9PPARA, PPARG, AKR1A1, ACE, MSTN, ALDH2
6MP:00053766.6APOH, PPARA, PPARG, AKR1A1, ACE, ACADM
7MP:00107686.2ALDH2, TNXB, APOH, PPARA, PPARG, AKR1A1

Publications for Alcoholic Cardiomyopathy

About this section
Sources:
50PubMed
See all sources

Articles related to Alcoholic Cardiomyopathy:

(show top 50)    (show all 154)
idTitleAuthorsYear
1
Alcohol septal ablation in obstructive hypertrophic cardiomyopathy: Four years of experience at a reference center. (24405560)
2014
2
Alcohol septal ablation for the treatment of obstructive hypertrophic cardiomyopathy: A demanding option. (24370444)
2013
3
Survival and pacemaker risk after alcohol septal ablation: informing the choice of invasive therapy for hypertrophic cardiomyopathy. (23890406)
2013
4
Alcohol septal ablation for obstructive hypertrophic cardiomyopathy: outcomes in young, middle-aged, and elderly patients. (22936613)
2013
5
Mid-term outcomes of alcohol septal ablation for obstructive hypertrophic cardiomyopathy in patients with sigmoid versus neutral ventricular septum. (23220977)
2012
6
The role of alcohol septal ablation in the treatment of left ventricular outflow tract obstruction in hypertrophic cardiomyopathy. (22093511)
2011
7
Alcoholic cardiomyopathy: a review. (21962423)
2011
8
Alcoholic cardiomyopathy. (20308914)
2010
9
Alcoholic cardiomyopathy: acetaldehyde, insulin insensitization and ER stress. (18479704)
2008
10
Successful alcohol septal ablation for late recurrence of left ventricular outflow tract obstruction after surgical myectomy in hypertrophic obstructive cardiomyopathy. (18468210)
2008
11
Expression of renin-angiotensin system and peroxisome proliferator-activated receptors in alcoholic cardiomyopathy. (18783396)
2008
12
Scintigraphic evaluation of cardiac metabolism and sympathetic nerve function in alcoholic cardiomyopathy. (16679703)
2006
13
A murine model of alcoholic cardiomyopathy: a role for zinc and metallothionein in fibrosis. (16049317)
2005
14
Pregnancy outcome in a mother with alcoholic cardiomyopathy. (16029303)
2005
15
Ethanol and acetaldehyde in alcoholic cardiomyopathy: from bad to ugly en route to oxidative stress. (15282111)
2004
16
Alcoholic cardiomyopathy and ventricular arrhythmias. (12684336)
2003
17
Release of matrix metalloproteinases following alcohol septal ablation in hypertrophic obstructive cardiomyopathy. (12505230)
2002
18
Echocardiographic evolution of left ventricular and left atrial thrombi in a patient with left ventricular dysfunction due to alcoholic cardiomyopathy, chronic atrial fibrillation and multiple non-fatal systemic embolisms. (11357926)
2001
19
Images in medicine: alcoholic cardiomyopathy a possible cause. (10858111)
2000
20
Long-term prognosis in patients with alcoholic cardiomyopathy and severe heart failure after total abstinence. (9164905)
1997
21
Alcoholic cardiomyopathy: is outcome linked to stimulus withdrawal? (8732367)
1996
22
Prediction of recovery after abstinence in alcoholic cardiomyopathy: role of hemodynamic and morphometric parameters. (8903537)
1996
23
The greater risk of alcoholic cardiomyopathy and myopathy in women compared with men. (7596003)
1995
24
Alcoholic cardiomyopathy. (8198205)
1994
25
The functional state of the creatine kinase system of myocardial mitochondria in alcoholic cardiomyopathy. (1743030)
1991
26
Relationship between morbidity and mortality due to alcoholic cardiomyopathy and alcohol consumption in Australia. (2343798)
1990
27
Risk factors in alcoholic cardiomyopathy. (2705634)
1989
28
Alcoholic cardiomyopathy. (2812553)
1989
29
Alcoholic cardiomyopathy in rats: inotropic responses to phenylephrine, glucagon, ouabain, and dobutamine. (3437459)
1987
30
The patient with alcoholic cardiomyopathy. (3437323)
1987
31
Normalization of variables of left ventricular function in patients with alcoholic cardiomyopathy after cessation of excessive alcohol intake: an echocardiographic study. (3609046)
1987
32
Is the rat a suitable model for studying alcoholic cardiomyopathy? Hemodynamic studies at various stages of chronic alcohol ingestion. (6743192)
1984
33
Impaired myocardial performance and response to calcium in experimental alcoholic cardiomyopathy. (7321050)
1981
34
Histocompatibility antigens and alcoholic cardiomyopathy. (6451049)
1980
35
Improvement of left ventricular function in alcoholic cardiomyopathy documented by serial gated cardiac pool scanning. (292382)
1979
36
Alcoholic cardiomyopathy. (694645)
1978
37
Complete heart block in alcoholic cardiomyopathy--a potentially reversible process. (694342)
1978
38
Alcoholic cardiomyopathy. (884942)
1977
39
Alcoholic cardiomyopathy. (890189)
1977
40
Alcoholic cardiomyopathy: a nursing approach. (243794)
1977
41
Role of acetaldehyde in the pathogenesis of alcoholic cardiomyopathy. (1036417)
1976
42
Lowering of blood acetaldehyde levels-a possible approach to prevention of alcoholic cardiomyopathy. (1036418)
1976
43
Alcoholic cardiomyopathy. II. The inhibition of cardiac microsomal protein synthesis by acetaldehyde. (4828692)
1974
44
Myocardial lesions in idiopathic and alcoholic cardiomyopathy. Study by ventricular septal biopsy. (5061696)
1972
45
Alcoholic cardiomyopathy. (5022007)
1972
46
Alcoholic cardiomyopathy. (4944526)
1971
47
Alcoholic cardiomyopathy. (6051265)
1967
48
Alcoholic cardiomyopathy. (5328823)
1966
49
ALCOHOLIC CARDIOMYOPATHY. (14317452)
1965
50
ALCOHOLIC CARDIOMYOPATHY. (14224479)
1965

Genetic Variations for Alcoholic Cardiomyopathy

About this section

Expression for genes affiliated with Alcoholic Cardiomyopathy

About this section
Sources:
1BioGPS, 15Gene Expression Omnibus DataSets
See all sources
Expression patterns in normal tissues for genes affiliated with Alcoholic Cardiomyopathy

Search GEO for disease gene expression data for Alcoholic Cardiomyopathy.

Pathways for genes affiliated with Alcoholic Cardiomyopathy

About this section
Sources:
29KEGG, 37NCBI BioSystems Database, 49PharmGKB, 53Reactome
See all sources

Compounds for genes affiliated with Alcoholic Cardiomyopathy

About this section
Sources:
44Novoseek, 28IUPHAR, 11DrugBank, 59Tocris Bioscience, 49PharmGKB, 24HMDB
See all sources

Compounds related to Alcoholic Cardiomyopathy according to GeneCards/GeneDecks:

(show top 50)    (show all 98)
idCompoundScoreTop Affiliating Genes
1mono(2-ethylhexyl)phthalate449.8PPARG, PPARA
2reglitazar289.8PPARG, PPARA
3mk-0767289.8PPARG, PPARA
4ragaglitazar44 2810.8PPARA, PPARG
5gi262570449.8PPARA, PPARG
6ad-5061289.8PPARG, PPARA
7ly-465608289.8PPARG, PPARA
8gw 1929449.8PPARA, PPARG
9ly-510929289.8PPARA, PPARG
10farglitazar289.8PPARG, PPARA
11tzd18289.8PPARG, PPARA
12gw409544289.8PPARA, PPARG
13ALEGLITAZAR 119.8PPARA, PPARG
14gw9578289.8PPARG, PPARA
15gw 764744 5910.8PPARG, PPARA
16bisphenol a diglycidyl ether449.8PPARG, PPARA
17tetradecylthioacetic acid449.8PPARA, PPARG
18gw50151644 2810.7PPARA, PPARG
193-{5-methoxy-1-[(4-methoxyphenyl)sulfonyl]-1H-indol-3-yl}propanoic acid119.7PPARA, PPARG
20tesaglitazar449.7PPARA, PPARG
21prostaglandin j2449.7PPARG, PPARA
22propionaldehyde449.7ALDH2, AKR1A1
23palmitoylethanolamide28 44 5911.7PPARG, PPARA
24muraglitazar49 4410.7PPARG, PPARA
25benzaldehyde44 2410.6ALDH2, AKR1A1
26octanoate449.5PPARA, PPARG, ACADM
27acetaldehyde44 28 2411.3PPARA, ALDH2, AKR1A1
28carnitine449.3PPARA, ACADM, PPARG
294-hydroxynonenal44 2410.2ALDH2, PPARA, AKR1A1
302-methylbutyryl-coa44 2410.2ACADM, PPARA, PPARG
31octanoyl-coa44 2410.2PPARG, PPARA, ACADM
32(2E)-Octenoyl-CoA249.2ACADM, PPARG, PPARA
33(2E)-Dodecenoyl-CoA249.1PPARA, PPARG, ACADM
34phenobarbital44 28 1111.1PPARG, PPARA, AKR1A1
35(2E)-Tetradecenoyl-CoA249.1ACADM, PPARG, PPARA
36stearoyl-coa44 2410.1PPARA, PPARG, ACADM
37folate449.0PPARA, APOH, AKR1A1, ALDH2
38telmisartan44 28 1111.0PPARA, PPARG, ACE
39(2E)-Decenoyl-CoA249.0ACADM, PPARG, PPARA
40metformin44 49 1110.9ACE, PPARG, PPARA
41(2E)-Hexadecenoyl-CoA248.8PPARG, PPARA, ACADM
42retinoid448.7PPARA, PPARG, AKR1A1, ALDH2
43prostacyclin448.6ACE, PPARA, PPARG, APOH
44aspirin44 49 28 2411.6PPARG, PPARA, APOH, ACE
45arginine448.6ALDH2, ACADM, AKR1A1, APOH, PPARA
46glutamate448.5APOH, AKR1A1, ACADM, ALDH2, PPARA
47creatinine448.2PPARA, ALDH2, ACE, AKR1A1, APOH
48cholesterol44 28 11 2411.0ALDH2, ACE, PPARG, PPARA, APOH
49glucose447.5ACE, ACADM, PPARG, PPARA, MSTN, APOH
50lipid447.3AKR1A1, PPARG, ACADM, ACE, PPARA, APOH

GO Terms for genes affiliated with Alcoholic Cardiomyopathy

About this section
Sources:
16Gene Ontology
See all sources

Cellular components related to Alcoholic Cardiomyopathy according to GeneCards/GeneDecks:

idNameGO IDScoreTop Affiliating Genes
1extracellular spaceGO:0056158.5MSTN, ACE, APOH, TNXB

Biological processes related to Alcoholic Cardiomyopathy according to GeneCards/GeneDecks:

(show all 7)
idNameGO IDScoreTop Affiliating Genes
1triglyceride metabolic processGO:0066419.7APOH, TNXB
2negative regulation of receptor biosynthetic processGO:0108719.5PPARG, PPARA
3negative regulation of sequestering of triglycerideGO:0108919.5PPARG, PPARA
4positive regulation of fatty acid oxidationGO:0463219.5PPARG, PPARA
5negative regulation of cholesterol storageGO:0108879.4PPARA, PPARG
6negative regulation of macrophage derived foam cell differentiationGO:0107459.3PPARG, PPARA
7response to coldGO:0094099.2ACADM, PPARG

Molecular functions related to Alcoholic Cardiomyopathy according to GeneCards/GeneDecks:

idNameGO IDScoreTop Affiliating Genes
1steroid hormone receptor activityGO:0037079.4PPARG, PPARA
2heparin bindingGO:0082019.3TNXB, APOH, MSTN
3ligand-activated sequence-specific DNA binding RNA polymerase II transcription factor activityGO:0048799.1PPARG, PPARA
4drug bindingGO:0081448.6ACE, PPARG, PPARA

Products for genes affiliated with Alcoholic Cardiomyopathy

About this section
  • Antibodies
  • Proteins
  • Lysates
  • Antibodies

Sources for Alcoholic Cardiomyopathy

About this section
3CDC
13ExPASy
14FMA
22GTR
23HGMD
24HMDB
25ICD10
26ICD10 via Orphanet
27ICD9CM
28IUPHAR
29KEGG
34MeSH
35MESH via Orphanet
36MGI
39NCIt
40NDF-RT
43NINDS
44Novoseek
46OMIM
47OMIM via Orphanet
50PubMed
51QIAGEN
57SNOMED-CT via Orphanet
60UMLS
61UMLS via Orphanet