MCID: ALC006
MIFTS: 52

Alcoholic Hepatitis malady

Gastrointestinal, Liver categories

Summaries for Alcoholic Hepatitis

Sources:
64Wikipedia, 33MalaCards
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Wikipedia:64 Alcoholic hepatitis is hepatitis (inflammation of the liver) due to excessive intake of alcohol. It is... more...

MalaCards: Alcoholic Hepatitis, also known as acute alcoholic liver disease, is related to hepatitis a and hepatitis c. An important gene associated with Alcoholic Hepatitis is F2 (coagulation factor II (thrombin)), and among its related pathways are Regulation by c-FLIP and ethanol degradation II. The compounds pentoxifylline and ulinastatin have been mentioned in the context of this disorder. Affiliated tissues include whole blood, brain and kidney, and related mouse phenotypes are liver/biliary system and hematopoietic system.

Aliases & Classifications for Alcoholic Hepatitis

Sources:
8Disease Ontology, 45Novoseek, 61UMLS, 57SNOMED-CT, 27ICD9CM, 40NCIt, 25ICD10
See all sources

Classifications:

Malacards categories (disease lists): (See all malacards categories)
Anatomical: Gastrointestinal, Liver


Aliases & Descriptions:

alcoholic hepatitis 8
acute alcoholic liver disease 8 61
acute alcoholic hepatitis 8 45
hepatitis, alcoholic 61
hepatitis alcoholic 45


External Ids:

Disease Ontology8 DOID:12351
ICD9CM27 571.1
SNOMED-CT57 9953008, 155810001
NCIt40 C34352
ICD1025 K70.1

Related Diseases for Alcoholic Hepatitis

Sources:
17GeneCards, 18GeneDecks
See all sources

Diseases related to Alcoholic Hepatitis via text searches within MalaCards or GeneCards/GeneDecks gene sharing:

(show top 50)    (show all 147)
idRelated DiseaseScoreTop Affiliating Genes
1hepatitis a31.9F2
2hepatitis c31.7TNF, CYP2E1, IL10, F2
3hepatitis b31.2FADD, F2
4alcoholic liver cirrhosis30.7AKR1A1, CYP2E1, IL8, F2
5viral hepatitis30.3F2, AKR1A1
6thrombocytopenia30.1F2, ADAMTS13
7fatty liver disease29.9CYP2E1
8acute pancreatitis29.9LBP, IL10, IL8
9insulin resistance29.9TNF, CYP2E1
10alcoholic pancreatitis29.9CYP2E1, AKR1A1
11acute liver failure29.9F2, HGF
12graves' disease29.9ICAM1
13hepatitis d11.0
14hepatitis e10.9
15hepatorenal syndrome10.3
16leukemoid reaction10.3
17nonalcoholic steatohepatitis10.3
18hepatitis c virus10.3
19portal hypertension10.1
20lung cancer10.0CYP2E1
21lupus erythematosus10.0F2
22oral cancer10.0CYP2E1
23purpura10.0ADAMTS13
24biliary atresia10.0HGF
25diabetic retinopathy10.0ICAM1
26hemolytic-uremic syndrome10.0ADAMTS13
27acute myocardial infarction10.0ADAMTS13
28molluscum contagiosum10.0IL18BP
29interstitial lung disease10.0TNF
30periodontitis10.0IL8
31obesity10.0CYP2E1, TNF
32atopy10.0IL10
33bronchiectasis10.0IL8
34cystic fibrosis10.0IL8, LBP
35periodontal disease10.0TNF, ICAM1
36crohn's disease10.0TNF
37myeloma10.0HGF, ICAM1
38alopecia areata10.0ICAM1
39bronchopulmonary dysplasia10.0IL8
40respiratory failure10.0TNF, ICAM1
41endometriosis10.0HGF, IL8
42arthropathy10.0TNF
43pulmonary fibrosis10.0IL8, HGF
44familial mediterranean fever10.0TNF
45hypertension10.0F2, ICAM1
46peptic ulcer10.0AKR1A1, IL8
47astrocytoma10.0LBP
48adenoma10.0DUOX1
49proliferative diabetic retinopathy10.0IL8, ICAM1, HGF
50chorioamnionitis10.0TNF, IL8

Graphical network of the top 20 diseases related to Alcoholic Hepatitis:



Diseases related to alcoholic hepatitis

Clinical Features for Alcoholic Hepatitis

Drugs & Therapeutics for Alcoholic Hepatitis

Sources:
5CenterWatch, 42NIH Clinical Center, 6ClinicalTrials, 61UMLS, 41NDF-RT
See all sources

Approved drugs:

Search CenterWatch for Alcoholic Hepatitis

Drug clinical trials:

Search ClinicalTrials for Alcoholic Hepatitis

Search NIH Clinical Center for Alcoholic Hepatitis

Search CenterWatch for Alcoholic Hepatitis

Genetic Tests for Alcoholic Hepatitis

Anatomical Context for Alcoholic Hepatitis

Sources:
33MalaCards
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MalaCards organs/tissues related to Alcoholic Hepatitis:

33
Whole blood, Brain, Kidney, Liver, Thyroid, Monocytes, T cells, B cells, Endothelial

Animal Models for Alcoholic Hepatitis or affiliated genes

Sources:
37MGI, 28inGenious Targeting Laboratory
See all sources

Publications for Alcoholic Hepatitis

Sources:
51PubMed
See all sources

Articles related to Alcoholic Hepatitis:

(show top 50)    (show all 548)
idTitleAuthorsYear
1
Prednisolone with vs without pentoxifylline and survival of patients with severe alcoholic hepatitis: a randomized clinical trial. (24026598)
2013
2
Systematic review: pentoxifylline for the treatment of severe alcoholic hepatitis. (23489011)
2013
3
Management practices of hepatitis C virus infected alcoholic hepatitis patients: A survey of physicians. (23667769)
2013
4
Human and experimental evidence supporting a role for osteopontin in alcoholic hepatitis. (23729174)
2013
5
Severe alcoholic hepatitis: glucocorticoid saves lives and transplantation is promising. (21633648)
2011
6
Symptoms and signs of acute alcoholic hepatitis. (21731904)
2011
7
In vitro steroid resistance correlates with outcome in severe alcoholic hepatitis. (21400552)
2011
8
Incidence and mortality of alcoholic hepatitis in Denmark 1999-2008: a nationwide population based cohort study. (21126790)
2011
9
Liver immunolocalization and plasma levels of MMP-9 in non-alcoholic steatohepatitis (NASH) and hepatitis C infection. (19604544)
2010
10
Can protein carbonyl/glutathione ratio be used as a potential biomarker to assess oxidative stress in alcoholic hepatitis? (23023309)
2010
11
Alcoholic hepatitis. (19812414)
2009
12
Review article: the diagnosis and management of alcoholic hepatitis. (19416132)
2009
13
Noninvasive laboratory tests proposed for predicting cirrhosis in patients with chronic hepatitis C are also useful in patients with non-alcoholic steatohepatitis. (19360373)
2009
14
Antioxidants plus corticosteroids in the treatment of severe acute alcoholic hepatitis: the question is still open. (18486264)
2008
15
A randomized trial of antioxidant therapy alone or with corticosteroids in acute alcoholic hepatitis. (17532088)
2007
16
Alcoholic hepatitis with leukemoid reaction after surgery. (16368495)
2006
17
Future use of the Glasgow alcoholic hepatitis score. (16344584)
2006
18
Serum C-reactive protein: a non-invasive marker of alcoholic hepatitis. (17101579)
2006
19
"Pseudotumoral" hepatic areas in acute alcoholic hepatitis: a computed tomography and histological study. (15784028)
2005
20
Association between plasma interleukin-18 levels and liver injury in chronic hepatitis C virus infection and non-alcoholic fatty liver disease. (16254258)
2005
21
A double-blind randomized controlled trial of infliximab associated with prednisolone in acute alcoholic hepatitis. (15122768)
2004
22
Early change in bilirubin levels is an important prognostic factor in severe alcoholic hepatitis treated with prednisolone. (14647046)
2003
23
Severe alcoholic hepatitis in Japan]. (12462051)
2002
24
Apoptosis in alcoholic hepatitis. (11943433)
2002
25
Hepatocyte apoptosis is a pathologic feature of human alcoholic hepatitis. (11281553)
2001
26
Infiltrating polymorphonuclear leukocytes and apoptotic bodies derived from hepatocytes but not from ballooning hepatocytes containing Mallory bodies show nuclear DNA fragmentation in alcoholic hepatitis. (10803784)
2000
27
Alcoholic hepatitis-the case for intensive management. (10908382)
2000
28
Pentoxifylline and alcoholic hepatitis. (11113103)
2000
29
Rapidly progressive liver injury and fatal alcoholic hepatitis occurring after liver transplantation in alcoholic patients. (10401763)
1999
30
Abnormalities of peripheral blood T lymphocytes and natural killer cells in alcoholic hepatitis persist after a 3-month withdrawal period. (9194923)
1997
31
Usefulness of technetium-99m-galactosyl human serum albumin liver scintigraphy for assessment of severity of alcoholic hepatitis. (8659699)
1996
32
Cytokine levels in acute alcoholic hepatitis: a sequential study. (7587970)
1995
33
Thrombocytopenia associated with platelet-associated immunoglobulin G in alcoholic hepatitis. (7827308)
1994
34
Alcoholic hepatitis and liver transplantation: the controversy continues. (8048716)
1994
35
Treatment of alcoholic hepatitis. (8303320)
1993
36
Hepatobiliary imaging in acute alcoholic hepatitis with fatty liver. (1611803)
1992
37
Prednisolone in severe alcoholic hepatitis. (1614484)
1992
38
Hepatocellular peroxisomes in human alcoholic and drug-induced hepatitis: a quantitative study. (1937386)
1991
39
Insulin and glucagon infusion in acute alcoholic hepatitis: a prospective randomized controlled trial. (1959860)
1991
40
Free radical generation by neutrophils: a potential mechanism of cellular injury in acute alcoholic hepatitis. (2824301)
1987
41
Hepatitis B specific markers in chronic alcoholic pancreatitis. (7083995)
1982
42
Abnormal apolipoprotein composition in alcoholic hepatitis. (6788090)
1981
43
Insulin and glucagon therapy for alcoholic hepatitis. (7014353)
1981
44
Sequential imaging of the progress of acute alcoholic hepatitis with ultrasound and isotopes. (7370504)
1980
45
Alcohol and the liver: 1. Acute alcoholic hepatitis. (7432281)
1980
46
Propylthiouracil treatment of alcoholic hepatitis. (758142)
1979
47
The role of lecithin:cholesterol acyltransferase deficiency in the apoprotein metabolism of alcoholic hepatitis. (746350)
1978
48
Depressed delayed cutaneous hypersensitivity in alcoholic hepatitis. (352138)
1978
49
Steroid treatment of alcoholic hepatitis. The yeas and the nays. (620902)
1978
50
Medical grand rounds. Alcoholic hepatitis. (978069)
1976

Genetic Variations for Alcoholic Hepatitis

Expression for genes affiliated with Alcoholic Hepatitis

Sources:
1BioGPS, 15Gene Expression Omnibus DataSets
See all sources
Expression patterns in normal tissues for genes affiliated with Alcoholic Hepatitis

Search GEO for disease gene expression data for Alcoholic Hepatitis.

Pathways for genes affiliated with Alcoholic Hepatitis

Sources:
54Reactome, 38NCBI BioSystems Database, 12EMD Millipore, 52QIAGEN, 30KEGG, 50PharmGKB
See all sources

Pathways related to Alcoholic Hepatitis according to GeneCards/GeneDecks:

(show all 20)
idSuper pathways (with members indented)ScoreTop Affiliating Genes
1
Hide members
10.4FADD, TNF
2
Hide members
10.4CYP2E1, ACSS2
310.4F2, TNF, ICAM1
410.4ICAM1, TNF, IL8
510.4IL8, IL10, TNF
610.4IL8, IL10, TNF
710.4IL10, TNF, ICAM1
8
Immune response Bacterial infections in normal airways
10.4IL8, LBP, TNF
9
Cytokine production by Th17 cells in CF (Mouse model)
10.4ICAM1, LBP, IL8
10
Hide members
10.3PIAS3, TNFRSF14, HGF
1110.3ICAM1, TNF, LBP, IL8
12
Hide members
10.3ICAM1, TNF, FADD, IL10
1310.3IL10, LBP, FADD, TNF
14
Hide members
10.3ALDH3A1, ACSS2, AKR1A1
15
Hide members
10.3LBP, FADD, TNF, TNFRSF14
16
Hide members
10.3ICAM1, TNFRSF14, TNF, FADD, IL8
17
Hide members
10.3IL8, IL10, LBP, FADD, TNF
18
Hide members
10.3ALDH3A1, ACSS2, CYP2E1, AKR1A1
19
Hide members
10.3HGF, TNF, PIAS3, IL10, IL8, F2
20
Hide members
10.3HGF, TNFRSF14, TNF, FADD, IL10, IL8

Compounds for genes affiliated with Alcoholic Hepatitis

Sources:
45Novoseek, 11DrugBank, 29IUPHAR, 60Tocris Bioscience, 50PharmGKB, 24HMDB
See all sources

Compounds related to Alcoholic Hepatitis according to GeneCards/GeneDecks:

(show top 50)    (show all 110)
idCompoundScoreTop Affiliating Genes
1pentoxifylline45 1111.9CYP2E1
2ulinastatin4510.9ICAM1
3cycloheximide4510.8HGF
4diphenyleneiodonium4510.8DUOX1, CYP2E1
5cdp5714510.8ICAM1, TNF, IL10
6gm-csf45 2911.8TNF, ICAM1, IL10
7interferon gamma4510.8IL10, ICAM1, TNF
8endotoxin4510.8ADAMTS13, LBP, ICAM1, IL18BP
9groalpha4510.8TNF, IL8, IL10, ICAM1
10lipoteichoic acid4510.7TNF, LBP, IL8, IL10
118-isoprostane4510.7ICAM1, TNF, IL10, IL8
12polymyxin b4510.7IL10, LBP, TNF, ICAM1, IL8
13sp 60012545 6011.7HGF, IL8, FADD, ICAM1, TNF
14n-tosyl-l-phenylalanine chloromethyl ketone4510.7TNF, ICAM1, IL8
15il 104510.7LBP, TNF, IL10, IL8
16tarc4510.7TNF, ICAM1, IL10, IL8
17pdtc4510.7IL8
18cyclophosphamide45 50 1112.7HGF, CYP2E1, ALDH3A1, ADAMTS13
19gabexate mesilate4510.7IL10, IL8, TNF
20simvastatin45 50 60 29 11 2415.7F2, IL8, IL10, TNF, ICAM1
21peptidoglycan45 2911.7IL10, LBP, TNF, IL8
22toxin-14510.7TNF, IL10, IL8
23h2o24510.7HGF, ICAM1, DUOX1, CYP2E1
24sb 20358045 6011.7IL10, ICAM1, IL8, HGF, TNF, CYP2E1
25ccl345 2911.7IL10, ICAM1, TNF, IL8
26azithromycin45 1111.7IL10, F2, IL8
27cyclosporin a45 29 6012.7HGF, TNF, IL8, IL10, ADAMTS13, ICAM1
28n acetylcysteine4510.7HGF, ICAM1, AKR1A1, IL8, TNF, F2
29acetaldehyde45 29 2412.7CYP2E1, ALDH3A1, HGF, AKR1A1, ACSS2, IL10
30lactate4510.7HGF, ICAM1, TNF, AKR1A1, CYP2E1, F2
31mip 1alpha4510.7IL8, IL10, TNF
32dexamethasone45 50 29 1113.6LBP, HGF, CYP2E1
33neopterin4510.6ICAM1, TNF, IL10, IL8
34histamine45 29 2412.6ICAM1, TNF, AKR1A1, HGF, IL10, IL8
35acetic acid45 29 11 2413.6ALDH3A1, ACSS2, AKR1A1, HGF
36natalizumab45 1111.6ICAM1, IL10, TNF
37creatinine4510.6CYP2E1, IL18BP, LBP, HGF, AKR1A1, ADAMTS13
38ethanol45 50 11 2413.6FADD, AKR1A1, ALDH3A1, ACSS2, CYP2E1, HGF
39actinomycin d4510.6IL8, LBP, FADD, TNF, HGF, ICAM1
40aprotinin45 1111.6IL8
41oxygen45 2411.5HGF, DUOX1, IL8, ALDH3A1, AKR1A1, LBP
42thalidomide45 50 60 1113.5CYP2E1, HGF, TNF, IL10
43superoxide45 2411.5DUOX1, AKR1A1, TNF, LBP
444-hydroxynonenal45 2411.5ALDH3A1, CYP2E1, IL10, AKR1A1
45nash4510.5TNF, AKR1A1, CYP2E1
465 aminosalicylic acid4510.4IL10, IL8, TNF
47il-124510.4TNF, IL8, IL10
48imiquimod45 29 60 1113.4IL10, IL8, TNF
49staurosporin4510.1ICAM1, TNF, IL8
50lipid4510.0ACSS2, AKR1A1, HGF, ALDH3A1, TNF, CYP2E1

GO Terms for genes affiliated with Alcoholic Hepatitis

Sources:
16Gene Ontology
See all sources

Cellular components related to Alcoholic Hepatitis according to GeneCards/GeneDecks:

idNameGO IDScoreTop Affiliating Genes
1extracellular spaceGO:00561510.1ADAMTS13, F2, IL18BP, IL8, IL10, LBP

Biological processes related to Alcoholic Hepatitis according to GeneCards/GeneDecks:

(show all 11)
idNameGO IDScoreTop Affiliating Genes
1negative regulation of growth of symbiont in hostGO:04413010.6TNF, LBP, IL10
2receptor biosynthetic processGO:03280010.6TNF, IL10
3cellular response to lipopolysaccharideGO:07122210.6IL8, IL10, ICAM1, LBP
4defense response to Gram-positive bacteriumGO:05083010.5TNF, TNFRSF14, LBP
5negative regulation of cytokine secretion involved in immune responseGO:00274010.5IL10
6response to drugGO:04249310.5ICAM1, TNF, CYP2E1, IL10, ALDH3A1
7cellular response to tumor necrosis factorGO:07135610.5IL18BP, IL8, ICAM1
8necrotic cell deathGO:07026510.4FADD, TNF
9cellular aldehyde metabolic processGO:00608110.4AKR1A1, ALDH3A1
10response to glucocorticoid stimulusGO:05138410.3IL10, ALDH3A1, TNF
11response to molecule of bacterial originGO:00223710.1IL10, IL8

Products for genes affiliated with Alcoholic Hepatitis

  • Antibodies
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  • Lysates
  • Antibodies

Sources for Alcoholic Hepatitis

3CDC
13ExPASy
14FMA
22GTR
23HGMD
24HMDB
25ICD10
26ICD10 via Orphanet
27ICD9CM
29IUPHAR
30KEGG
35MeSH
36MESH via Orphanet
37MGI
40NCIt
41NDF-RT
44NINDS
45Novoseek
47OMIM
48OMIM via Orphanet
51PubMed
52QIAGEN
58SNOMED-CT via Orphanet
61UMLS
62UMLS via Orphanet