MCID: ALC006
MIFTS: 58

Alcoholic Hepatitis malady

Gastrointestinal diseases, Liver diseases categories
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Summaries for Alcoholic Hepatitis

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Wikipedia:65 Alcoholic hepatitis is hepatitis (inflammation of the liver) due to excessive intake of alcohol. It is... more...

MalaCards based summary: Alcoholic Hepatitis, also known as acute alcoholic liver disease, is related to hepatitis and hepatorenal syndrome. An important gene associated with Alcoholic Hepatitis is F2 (coagulation factor II (thrombin)), and among its related pathways are Legionellosis and EBV LMP1 signaling. The compounds n-tosyl-l-phenylalanine chloromethyl ketone and azithromycin have been mentioned in the context of this disorder. Affiliated tissues include liver, brain and neutrophil, and related mouse phenotypes are no phenotypic analysis and liver/biliary system.

Aliases & Classifications for Alcoholic Hepatitis

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Alcoholic Hepatitis, Aliases & Descriptions:

Name: Alcoholic Hepatitis 30 8
Acute Alcoholic Liver Disease 8 62
Acute Alcoholic Hepatitis 8 44
 
Hepatitis, Alcoholic 62
Hepatitis Alcoholic 44


Classifications:

Malacards categories (disease lists): (See all malacards categories)
Anatomical: Gastrointestinal diseases, Liver diseases


External Ids:

Disease Ontology8 DOID:12351
NCIt39 C34352
SNOMED-CT57 155810001, 9953008
ICD9CM27 571.1
ICD1025 K70.1

Related Diseases for Alcoholic Hepatitis

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Diseases related to Alcoholic Hepatitis via text searches within MalaCards or GeneCards/GeneDecks gene sharing:

(show top 50)    (show all 110)
idRelated DiseaseScoreTop Affiliating Genes
1hepatitis32.3F2, CYP2E1, HGF
2hepatorenal syndrome31.3F2
3hepatitis c30.7F2, CYP2E1, IL10
4hepatitis b30.6F2, IL10
5liver cirrhosis30.5F2, CYP2E1, HGF
6alcoholic liver cirrhosis30.5F2, CYP2E1, IL8
7acute liver failure30.4HGF, F2
8peritonitis30.2TNF, F2
9acute pancreatitis29.9IL8, IL10
10pancreatitis29.8CYP2E1, ICAM1, IL10
11pneumonia29.3TNF, ICAM1, IL22, IL10, IL8
12hepatitis a10.7
13liver disease10.5
14blau syndrome10.4TNF
15hepatitis c virus10.4
16blindness10.4
17interstitial lung disease10.4TNF
18meningitis10.4IL8
19rheumatoid vasculitis10.4ICAM1
20leukostasis10.4ICAM1
21leukemoid reaction10.3
22nonalcoholic steatohepatitis10.3
23leishmaniasis10.3IL10
24chorioamnionitis10.2IL8, TNF
25arthritis10.2IL8, TNF
26hepatic encephalopathy10.2
27galactosemia10.2HGF, F2
28adult respiratory distress syndrome10.2TNF, IL8
29common cold10.2IL8, ICAM1
30allergic rhinitis10.2IL8, ICAM1
31cork-handlers' disease10.2IL8, F2
32behcet's disease10.2TNF, IL8
33vernal keratoconjunctivitis10.2ICAM1, IL8
34arteriosclerosis obliterans10.2HGF, ICAM1
35rhinitis10.1ICAM1, IL8
36arteriosclerosis10.1ICAM1, HGF
37hypertension10.1
38thrombocytopenia10.1
39portal hypertension10.1
40esophagitis10.1
41pulmonary sarcoidosis10.1ICAM1, TNF
42respiratory failure10.1ICAM1, TNF
43monocytic leukemia10.1TNF, IL8
44hepatoblastoma10.1HGF, CYP2E1
45chronic obstructive pulmonary disease10.1IL8, TNF, CYP2E1
46periodontal disease10.1IL8, TNF
47acute graft versus host disease10.1IL10, TNF
48demyelinating disease10.0IL10, TNF
49proliferative diabetic retinopathy10.0HGF, IL8, ICAM1
50vasculitis10.0ICAM1, TNF, F2

Graphical network of the top 20 diseases related to Alcoholic Hepatitis:



Diseases related to alcoholic hepatitis

Symptoms for Alcoholic Hepatitis

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Drugs & Therapeutics for Alcoholic Hepatitis

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Drug clinical trials:

Search ClinicalTrials for Alcoholic Hepatitis

Search NIH Clinical Center for Alcoholic Hepatitis

Genetic Tests for Alcoholic Hepatitis

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Anatomical Context for Alcoholic Hepatitis

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MalaCards organs/tissues related to Alcoholic Hepatitis:

32
Liver, Brain, Neutrophil, T cells, Monocytes, Testes, Bone, Whole blood, Kidney, Thyroid, Prostate, Endothelial

Animal Models for Alcoholic Hepatitis or affiliated genes

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MGI Mouse Phenotypes related to Alcoholic Hepatitis:

36 (show all 13)
idDescriptionMGI Source AccessionScoreTop Affiliating Genes
1MP:00030128.1HGF, IL10, IL22, TNF
2MP:00053708.0CYP2E1, TNF, IL22, IL10, HGF
3MP:00053888.0F2, TNF, IL22, IL10
4MP:00020067.9CYP2E1, TNF, ICAM1, IL22, IL10
5MP:00053817.8F2, TNF, ICAM1, IL22, IL10
6MP:00107717.8F2, TNF, ICAM1, IL22, IL10
7MP:00053847.7HGF, IL10, ICAM1, TNF, F2
8MP:00053857.6F2, CYP2E1, TNF, ICAM1, IL10, HGF
9MP:00053877.4F2, TNF, ICAM1, IL22, IL10, IL8
10MP:00053767.3F2, CYP2E1, TNF, ICAM1, IL22, IL10
11MP:00053787.3F2, TNF, ICAM1, IL22, IL10, HGF
12MP:00053977.0HGF, IL8, IL10, IL22, ICAM1, TNF
13MP:00107687.0F2, CYP2E1, TNF, ICAM1, IL22, IL10

Publications for Alcoholic Hepatitis

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Articles related to Alcoholic Hepatitis:

(show top 50)    (show all 521)
idTitleAuthorsYear
1
TLR3/4 signaling is mediated via the NFI_B-CXCR4/7 pathway in human alcoholic hepatitis and non-alcoholic steatohepatitis which formed Mallory-Denk bodies. (24997224)
2014
2
Liver progenitor cell markers correlate with liver damage and predict short-term mortality in patients with alcoholic hepatitis. (22278680)
2012
3
Molecular targets in the treatment of alcoholic hepatitis. (23112542)
2012
4
Severe acute alcoholic hepatitis and hepatorenal syndrome: role of transjugular intrahepatic portosystemic stent shunt. (22802893)
2012
5
Severe alcoholic hepatitis: glucocorticoid saves lives and transplantation is promising. (21633648)
2011
6
Definition, epidemiology and magnitude of alcoholic hepatitis. (21731902)
2011
7
Development of multiple peribiliary cysts following acute alcoholic hepatitis. (20658328)
2010
8
The place of liver transplantation in the treatment of severe alcoholic hepatitis. (20347501)
2010
9
Alcoholic hepatitis 2010: a clinician's guide to diagnosis and therapy. (20954276)
2010
10
Acetate, the key modulator of inflammatory responses in acute alcoholic hepatitis. (20232292)
2010
11
Glucocorticoids can help in acute severe alcoholic hepatitis. (19566906)
2009
12
Alcoholic hepatitis. (19812414)
2009
13
Antioxidants plus corticosteroids in the treatment of severe acute alcoholic hepatitis: the question is still open. (18486264)
2008
14
Alcoholic hepatitis with leukemoid reaction after surgery. (16368495)
2006
15
Future use of the Glasgow alcoholic hepatitis score. (16344584)
2006
16
Regulation of fat metabolism in the liver: link to non-alcoholic hepatic steatosis and impact of physical exercise. (16649140)
2006
17
Current concepts and controversies in the treatment of alcoholic hepatitis. (17109510)
2006
18
Serum C-reactive protein: a non-invasive marker of alcoholic hepatitis. (17101579)
2006
19
Duplex Doppler ultrasound of the hepatic artery in patients with acute alcoholic hepatitis. (11960073)
2002
20
Role of Kupffer cells in alcoholic hepatitis. (12062631)
2002
21
Is pentoxifylline the answer for alcoholic hepatitis? (12170912)
2002
22
Influence of superimposed alcoholic hepatitis on the outcome of liver transplantation for end-stage alcoholic liver disease. (12044530)
2002
23
Free radicals, chemokines, and cell injury in HIV-1 and SIV infections and alcoholic hepatitis. (11744325)
2001
24
Serum laminin and type IV collagen are accurate markers of histologically severe alcoholic hepatitis in patients with cirrhosis. (10735610)
2000
25
Antioxidants attenuate nuclear factor-kappa B activation and tumor necrosis factor-alpha production in alcoholic hepatitis patient monocytes and rat Kupffer cells, in vitro. (10614719)
1999
26
Nonalcoholic steatohepatitis. Clinicopathological comparison with alcoholic hepatitis in ambulatory and hospitalized patients. (8565753)
1996
27
Prognostic factors for short-term survival in alcoholic hepatitis in Japan: analysis by logistic regression. (8986243)
1996
28
Protein energy malnutrition in severe alcoholic hepatitis: diagnosis and response to treatment. The VA Cooperative Study Group #275. (8523623)
1995
29
Lack of plasma complement activation in severe acute alcoholic hepatitis. (8749823)
1995
30
Thrombocytopenia associated with platelet-associated immunoglobulin G in alcoholic hepatitis. (7827308)
1994
31
Liver transplantation for alcoholic liver disease: survival of patients transplanted with alcoholic hepatitis plus cirrhosis as compared with those with cirrhosis alone. (8279673)
1993
32
Immunoglobulin A antibody to a 200-kilodalton cytosolic acetaldehyde adduct in alcoholic hepatitis. (1451979)
1992
33
Corticosteroids and alcoholic hepatitis. (1824838)
1991
34
A randomized, controlled trial of treatment of alcoholic hepatitis with parenteral nutrition and oxandrolone. II. Short-term effects on nitrogen metabolism, metabolic balance, and nutrition. (1909086)
1991
35
Do corticosteroids reduce mortality from alcoholic hepatitis? A meta-analysis of the randomized trials. (2142869)
1990
36
Increased plasma tumor necrosis factor in severe alcoholic hepatitis. (2339855)
1990
37
Alcoholic hepatitis: pathogenesis and approaches to treatment. (2237274)
1990
38
Corticosteroid therapy of alcoholic hepatitis: how many studies will it take? (2205560)
1990
39
Tumor necrosis factor in alcoholic hepatitis. (2777030)
1989
40
Metabolic effects of enteral formula feeding in alcoholic hepatitis. (3119452)
1987
41
Plasma lipoprotein composition in alcoholic hepatitis: accumulation of apolipoprotein E-rich high density lipoprotein and preferential reappearance of "light'-HDL during partial recovery. (7097121)
1982
42
Double-blind, controlled trial of propylthiouracil in patients with severe acute alcoholic hepatitis. (7037524)
1982
43
Acute alcoholic hepatitis: clinical, biochemical and liver scintiscanning correlation in assessing prognosis. (472544)
1979
44
Hyperalimentation in alcoholic hepatitis. (119434)
1979
45
The role of lecithin:cholesterol acyltransferase deficiency in the apoprotein metabolism of alcoholic hepatitis. (746350)
1978
46
Immunological aspects of alcoholic hepatitis. (95720)
1978
47
Alcoholic hepatitis. (644352)
1978
48
Lymphocyte cytotoxicity in alcoholic hepatitis. (65306)
1977
49
Editorial: Alcoholic hepatitis and corticosteroids. (4751745)
1973
50
Prednisone therapy of acute alcoholic hepatitis. Report of a controlled trial. (4751740)
1973

Variations for Alcoholic Hepatitis

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Expression for genes affiliated with Alcoholic Hepatitis

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Expression patterns in normal tissues for genes affiliated with Alcoholic Hepatitis

Search GEO for disease gene expression data for Alcoholic Hepatitis.

Pathways for genes affiliated with Alcoholic Hepatitis

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Pathways related to Alcoholic Hepatitis according to GeneCards/GeneDecks:

(show all 34)
idSuper pathways (with members indented)ScoreTop Affiliating Genes
19.5TNF, IL8
29.5IL8, TNF
3
Show member pathways
Calcium signaling in the CD4+ TCR pathway37
9.5IL8, TNF
49.4ICAM1, IL8
5
Show member pathways
9.4ICAM1, IL8
69.3TNF, ICAM1
79.3ICAM1, TNF
8
Show member pathways
9.2IL8, TNF, CYP2E1
9
Show member pathways
9.1IL10, TNF
109.1TNF, IL10
119.1TNF, IL10
12
Show member pathways
IL27-mediated signaling events37
9.1IL10, TNF
139.0ICAM1, IL10
14
Show member pathways
thioredoxin pathway37
9.0F2, ICAM1, TNF
15
Show member pathways
8.9IL8, ICAM1, TNF
168.9IL8, ICAM1, TNF
178.9TNF, IL8, ICAM1
188.9IL8, TNF, ICAM1
198.9ICAM1, TNF, IL8
20
Show member pathways
IL23-mediated signaling events37
Immune response IL 10 signaling pathway60
Angiopoietin receptor Tie2-mediated signaling37
Development PDGF signaling via STATs and NF kB60
Development Angiopoietin Tie2 signaling60
8.8IL10, TNF, F2
21
Show member pathways
Toll-like receptor signaling pathway37
Regulation of toll-like receptor signaling pathway37
8.7TNF, IL8, IL10
228.7TNF, IL8, IL10
238.7IL8, IL10, TNF
248.7IL10, TNF, IL8
258.7IL10, TNF, IL8
26
Show member pathways
8.6IL22, IL10, TNF
27
Show member pathways
8.5ICAM1, IL10, TNF
288.5ICAM1, IL10, TNF
29
Show member pathways
7.7IL22, HGF, IL8, IL10, TNF
30
Show member pathways
7.7TNF, HGF, IL8, IL22, IL10
31
Show member pathways
7.7HGF, TNF, IL10, IL22, IL8
327.6ICAM1, IL8, TNF, IL10, HGF
33
Show member pathways
7.4HGF, TNF, IL22, IL10, IL8, F2
34
Show member pathways
7.4TNF, IL22, IL10, IL8, HGF, F2

Compounds for genes affiliated with Alcoholic Hepatitis

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Compounds related to Alcoholic Hepatitis according to GeneCards/GeneDecks:

(show top 50)    (show all 163)
idCompoundScoreTop Affiliating Genes
1n-tosyl-l-phenylalanine chloromethyl ketone449.3TNF, ICAM1, IL8
2azithromycin44 1110.2F2, IL10, IL8
3staurosporin449.1TNF, ICAM1, IL8
4gabexate mesilate449.1IL8, IL10, TNF
5toxin-1449.1TNF, IL10, IL8
6mip 1alpha449.1TNF, IL10, IL8
7egcg449.0HGF, IL8, TNF, CYP2E1
85 aminosalicylic acid449.0TNF, IL10, IL8
9il-12449.0TNF, IL10, IL8
10diphenyleneiodonium449.0CYP2E1, TNF, ICAM1, IL8
11cdp571448.9IL10, ICAM1, TNF
12interferon gamma448.9IL10, ICAM1, TNF
13imiquimod44 61 28 1111.9IL8, IL10, TNF
14budesonide44 50 1110.9IL8, ICAM1, TNF
15hyaluronic acid44 249.9HGF, IL8, ICAM1, F2
16pdtc448.9HGF, IL8, ICAM1, TNF
17aprotinin44 119.8F2, IL10, IL8, HGF
18sp 60012544 619.8HGF, IL8, ICAM1, TNF
19triptolide448.8TNF, ICAM1, IL8
20natalizumab44 119.8TNF, ICAM1, IL10
21mg 13244 619.8TNF, ICAM1, IL8, HGF
22herbimycin a44 619.7TNF, ICAM1, IL8, HGF
23thalidomide44 50 61 1111.7HGF, IL10, TNF, CYP2E1
24go 697644 619.6TNF, ICAM1, IL8
25hydrocortisone44 2 61 1111.6HGF, IL8, IL10, TNF
26ulinastatin448.6TNF, ICAM1, IL10, IL8
27polymyxin b448.5IL8, IL10, ICAM1, TNF
28groalpha448.5IL8, IL10, ICAM1, TNF
29gm-csf44 289.5TNF, ICAM1, IL10, IL8
30n acetylcysteine448.5F2, TNF, ICAM1, IL8, HGF
318-isoprostane448.5TNF, ICAM1, IL10, IL8
32tarc448.5IL8, IL10, ICAM1, TNF
33ccl344 289.5TNF, ICAM1, IL10, IL8
34okt3448.5TNF, ICAM1, IL10
35neopterin448.5TNF, ICAM1, IL10, IL8
36genistein44 28 61 2 24 1113.4CYP2E1, TNF, ICAM1, IL8, HGF
37endotoxin448.3TNF, ICAM1, IL10, IL8
38simvastatin44 50 61 28 24 1113.2F2, TNF, ICAM1, IL10, IL8
39lactate448.2F2, CYP2E1, TNF, ICAM1, IL8, HGF
40pentoxifylline44 119.2IL8, IL10, ICAM1, TNF, CYP2E1
41prostacyclin448.2HGF, IL10, ICAM1, TNF
42h2o2448.2CYP2E1, TNF, ICAM1, IL8, HGF
43histamine44 28 2410.0TNF, ICAM1, IL10, IL8, HGF
44ly294002448.0TNF, ICAM1, IL10, IL8, HGF
45pge2448.0TNF, ICAM1, IL10, IL8, HGF
46oxygen44 248.9CYP2E1, TNF, ICAM1, IL22, IL8, HGF
47cycloheximide447.8TNF, ICAM1, IL10, IL8, HGF
48cyclosporin a44 28 619.7F2, TNF, ICAM1, IL10, IL8, HGF
49sb 20358044 618.7CYP2E1, TNF, ICAM1, IL10, IL8, HGF
50dexamethasone44 50 28 1110.7CYP2E1, TNF, ICAM1, IL10, IL8, HGF

GO Terms for genes affiliated with Alcoholic Hepatitis

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Cellular components related to Alcoholic Hepatitis according to GeneCards/GeneDecks:

idNameGO IDScoreTop Affiliating Genes
1extracellular regionGO:0055768.2HGF, IL8, IL22, TNF, F2
2extracellular spaceGO:0056156.5HGF, F2, TNF, ICAM1, IL22, IL10

Biological processes related to Alcoholic Hepatitis according to GeneCards/GeneDecks:

(show all 20)
idNameGO IDScoreTop Affiliating Genes
1embryonic digestive tract developmentGO:0485669.8TNF, IL8
2acute-phase responseGO:0069539.7F2, IL22
3calcium-mediated signalingGO:0197229.6IL8, TNF
4cellular response to interleukin-1GO:0713479.6IL8, ICAM1
5positive regulation of phosphatidylinositol 3-kinase signalingGO:0140689.6F2, HGF
6response to molecule of bacterial originGO:0022379.5IL8, IL10
7positive regulation of nitric oxide biosynthetic processGO:0454299.5ICAM1, TNF
8receptor biosynthetic processGO:0328009.5IL10, TNF
9regulation of cell adhesionGO:0301559.4IL8, ICAM1
10negative regulation of cytokine secretion involved in immune responseGO:0027409.4TNF, IL10
11negative regulation of growth of symbiont in hostGO:0441309.4IL10, TNF
12positive regulation of peptidyl-tyrosine phosphorylationGO:0507319.4HGF, ICAM1
13negative regulation of interleukin-6 productionGO:0327159.4IL10, TNF
14positive regulation of cytokine secretionGO:0507159.4IL10, TNF
15response to activityGO:0148239.3TNF, IL10
16cellular response to tumor necrosis factorGO:0713569.1IL8, ICAM1
17cellular response to lipopolysaccharideGO:0712228.9ICAM1, IL10, IL8
18response to glucocorticoidGO:0513848.9IL10, IL22, TNF
19inflammatory responseGO:0069548.5IL8, IL10, IL22, TNF
20response to drugGO:0424938.5CYP2E1, TNF, ICAM1, IL10

Molecular functions related to Alcoholic Hepatitis according to GeneCards/GeneDecks:

idNameGO IDScoreTop Affiliating Genes
1cytokine activityGO:0051258.6IL10, IL22, TNF
2growth factor activityGO:0080838.6HGF, IL10, F2

Products for genes affiliated with Alcoholic Hepatitis

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Sources for Alcoholic Hepatitis

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3CDC
13ExPASy
14FMA
22GTR
23HGMD
24HMDB
25ICD10
26ICD10 via Orphanet
27ICD9CM
28IUPHAR
29KEGG
34MeSH
35MESH via Orphanet
36MGI
39NCIt
40NDF-RT
43NINDS
44Novoseek
46OMIM
47OMIM via Orphanet
51PubMed
52QIAGEN
58SNOMED-CT via Orphanet
62UMLS
63UMLS via Orphanet