MCID: ALC006
MIFTS: 57

Alcoholic Hepatitis malady

Gastrointestinal diseases, Liver diseases categories

Summaries for Alcoholic Hepatitis

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66Wikipedia, 34MalaCards
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Wikipedia:66 Alcoholic hepatitis is hepatitis (inflammation of the liver) due to excessive intake of alcohol. It is... more...

MalaCards: Alcoholic Hepatitis, also known as acute alcoholic liver disease, is related to hepatitis and hepatorenal syndrome. An important gene associated with Alcoholic Hepatitis is F2 (coagulation factor II (thrombin)), and among its related pathways are Legionellosis and EBV LMP1 signaling. The compounds n-tosyl-l-phenylalanine chloromethyl ketone and azithromycin have been mentioned in the context of this disorder. Affiliated tissues include liver, brain and t cells, and related mouse phenotypes are no phenotypic analysis and liver/biliary system.

Aliases & Classifications for Alcoholic Hepatitis

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9Disease Ontology, 63UMLS, 46Novoseek, 59SNOMED-CT, 41NCIt, 28ICD9CM, 26ICD10
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Classifications:

Malacards categories (disease lists): (See all malacards categories)
Anatomical: Gastrointestinal diseases, Liver diseases


Aliases & Descriptions:

alcoholic hepatitis 9
acute alcoholic liver disease 9 63
acute alcoholic hepatitis 9 46
hepatitis, alcoholic 63
hepatitis alcoholic 46


External Ids:

Disease Ontology9 DOID:12351
NCIt41 C34352
SNOMED-CT59 155810001, 9953008
ICD9CM28 571.1
ICD1026 K70.1

Related Diseases for Alcoholic Hepatitis

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Sources:
18GeneCards, 19GeneDecks
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Diseases related to Alcoholic Hepatitis via text searches within MalaCards or GeneCards/GeneDecks gene sharing:

(show top 50)    (show all 105)
idRelated DiseaseScoreTop Affiliating Genes
1hepatitis32.0F2, CYP2E1, HGF
2hepatorenal syndrome30.7F2
3hepatitis c30.6F2, CYP2E1, IL10
4hepatitis b30.4F2, IL10
5liver cirrhosis30.4F2, CYP2E1, HGF
6alcoholic liver cirrhosis30.3F2, CYP2E1, IL8
7acute liver failure30.1HGF, F2
8peritonitis30.0TNF, F2
9acute pancreatitis29.9IL8, IL10
10pancreatitis29.9CYP2E1, ICAM1, IL10
11pneumonia29.8TNF, ICAM1, IL22, IL10, IL8
12hepatitis a10.7
13liver disease10.5
14blindness10.4
15hepatitis c virus10.4
16leukemoid reaction10.3
17nonalcoholic steatohepatitis10.3
18hepatic encephalopathy10.2
19portal hypertension10.1
20esophagitis10.1
21hypertension10.1
22thrombocytopenia10.1
23blau syndrome10.1TNF
24interstitial lung disease10.1TNF
25meningitis10.1IL8
26rheumatoid vasculitis10.1ICAM1
27leukostasis10.1ICAM1
28leishmaniasis10.1IL10
29chorioamnionitis10.1IL8, TNF
30arthritis10.1IL8, TNF
31galactosemia10.1HGF, F2
32adult respiratory distress syndrome10.0TNF, IL8
33common cold10.0IL8, ICAM1
34cork-handlers' disease10.0IL8, F2
35allergic rhinitis10.0IL8, ICAM1
36behcet's disease10.0TNF, IL8
37arteriosclerosis obliterans10.0HGF, ICAM1
38vernal keratoconjunctivitis10.0ICAM1, IL8
39rhinitis10.0ICAM1, IL8
40arteriosclerosis10.0ICAM1, HGF
41pulmonary sarcoidosis10.0ICAM1, TNF
42respiratory failure10.0ICAM1, TNF
43monocytic leukemia10.0TNF, IL8
44hepatoblastoma10.0HGF, CYP2E1
45pulmonary disease, chronic obstructive10.0IL8, TNF, CYP2E1
46periodontal disease10.0IL8, TNF
47acute graft versus host disease10.0IL10, TNF
48proliferative diabetic retinopathy10.0HGF, IL8, ICAM1
49vasculitis10.0ICAM1, TNF, F2
50relapsing-remitting multiple sclerosis10.0ICAM1, IL10

Graphical network of the top 20 diseases related to Alcoholic Hepatitis:



Diseases related to alcoholic hepatitis

Symptoms for Alcoholic Hepatitis

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Drugs & Therapeutics for Alcoholic Hepatitis

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Sources:
6CenterWatch, 43NIH Clinical Center, 7ClinicalTrials, 63UMLS, 42NDF-RT
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Approved drugs:

Search CenterWatch for Alcoholic Hepatitis

Drug clinical trials:

Search ClinicalTrials for Alcoholic Hepatitis

Search NIH Clinical Center for Alcoholic Hepatitis

Search CenterWatch for Alcoholic Hepatitis

Genetic Tests for Alcoholic Hepatitis

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Anatomical Context for Alcoholic Hepatitis

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34MalaCards
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MalaCards organs/tissues related to Alcoholic Hepatitis:

34
Liver, Brain, T cells, Monocytes, Testes, Bone, Prostate, Thyroid, Kidney, Whole blood, Endothelial

Animal Models for Alcoholic Hepatitis or affiliated genes

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38MGI
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MGI Mouse Phenotypes related to Alcoholic Hepatitis:

38 (show all 13)
idDescriptionMGI Source AccessionScoreTop Affiliating Genes
1MP:00030128.1HGF, IL10, IL22, TNF
2MP:00053708.0CYP2E1, TNF, IL22, IL10, HGF
3MP:00053888.0F2, TNF, IL22, IL10
4MP:00020067.9CYP2E1, TNF, ICAM1, IL22, IL10
5MP:00053817.8F2, TNF, ICAM1, IL22, IL10
6MP:00107717.8F2, TNF, ICAM1, IL22, IL10
7MP:00053847.7HGF, IL10, ICAM1, TNF, F2
8MP:00053857.6F2, CYP2E1, TNF, ICAM1, IL10, HGF
9MP:00053877.4F2, TNF, ICAM1, IL22, IL10, IL8
10MP:00053767.3F2, CYP2E1, TNF, ICAM1, IL22, IL10
11MP:00053787.3F2, TNF, ICAM1, IL22, IL10, HGF
12MP:00053977.0HGF, IL8, IL10, IL22, ICAM1, TNF
13MP:00107687.0F2, CYP2E1, TNF, ICAM1, IL22, IL10

Publications for Alcoholic Hepatitis

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53PubMed
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Articles related to Alcoholic Hepatitis:

(show top 50)    (show all 500)
idTitleAuthorsYear
1
Liver progenitor cell markers correlate with liver damage and predict short-term mortality in patients with alcoholic hepatitis. (22278680)
2012
2
Molecular targets in the treatment of alcoholic hepatitis. (23112542)
2012
3
Severe acute alcoholic hepatitis and hepatorenal syndrome: role of transjugular intrahepatic portosystemic stent shunt. (22802893)
2012
4
Severe alcoholic hepatitis: glucocorticoid saves lives and transplantation is promising. (21633648)
2011
5
Definition, epidemiology and magnitude of alcoholic hepatitis. (21731902)
2011
6
Development of multiple peribiliary cysts following acute alcoholic hepatitis. (20658328)
2010
7
The place of liver transplantation in the treatment of severe alcoholic hepatitis. (20347501)
2010
8
Alcoholic hepatitis 2010: a clinician's guide to diagnosis and therapy. (20954276)
2010
9
Acetate, the key modulator of inflammatory responses in acute alcoholic hepatitis. (20232292)
2010
10
Glucocorticoids can help in acute severe alcoholic hepatitis. (19566906)
2009
11
Alcoholic hepatitis. (19812414)
2009
12
Antioxidants plus corticosteroids in the treatment of severe acute alcoholic hepatitis: the question is still open. (18486264)
2008
13
Alcoholic hepatitis with leukemoid reaction after surgery. (16368495)
2006
14
Future use of the Glasgow alcoholic hepatitis score. (16344584)
2006
15
Regulation of fat metabolism in the liver: link to non-alcoholic hepatic steatosis and impact of physical exercise. (16649140)
2006
16
Current concepts and controversies in the treatment of alcoholic hepatitis. (17109510)
2006
17
Serum C-reactive protein: a non-invasive marker of alcoholic hepatitis. (17101579)
2006
18
Duplex Doppler ultrasound of the hepatic artery in patients with acute alcoholic hepatitis. (11960073)
2002
19
Role of Kupffer cells in alcoholic hepatitis. (12062631)
2002
20
Is pentoxifylline the answer for alcoholic hepatitis? (12170912)
2002
21
Influence of superimposed alcoholic hepatitis on the outcome of liver transplantation for end-stage alcoholic liver disease. (12044530)
2002
22
Free radicals, chemokines, and cell injury in HIV-1 and SIV infections and alcoholic hepatitis. (11744325)
2001
23
Serum laminin and type IV collagen are accurate markers of histologically severe alcoholic hepatitis in patients with cirrhosis. (10735610)
2000
24
Antioxidants attenuate nuclear factor-kappa B activation and tumor necrosis factor-alpha production in alcoholic hepatitis patient monocytes and rat Kupffer cells, in vitro. (10614719)
1999
25
Nonalcoholic steatohepatitis. Clinicopathological comparison with alcoholic hepatitis in ambulatory and hospitalized patients. (8565753)
1996
26
Prognostic factors for short-term survival in alcoholic hepatitis in Japan: analysis by logistic regression. (8986243)
1996
27
Protein energy malnutrition in severe alcoholic hepatitis: diagnosis and response to treatment. The VA Cooperative Study Group #275. (8523623)
1995
28
Lack of plasma complement activation in severe acute alcoholic hepatitis. (8749823)
1995
29
Thrombocytopenia associated with platelet-associated immunoglobulin G in alcoholic hepatitis. (7827308)
1994
30
Liver transplantation for alcoholic liver disease: survival of patients transplanted with alcoholic hepatitis plus cirrhosis as compared with those with cirrhosis alone. (8279673)
1993
31
Immunoglobulin A antibody to a 200-kilodalton cytosolic acetaldehyde adduct in alcoholic hepatitis. (1451979)
1992
32
Corticosteroids and alcoholic hepatitis. (1824838)
1991
33
A randomized, controlled trial of treatment of alcoholic hepatitis with parenteral nutrition and oxandrolone. II. Short-term effects on nitrogen metabolism, metabolic balance, and nutrition. (1909086)
1991
34
Do corticosteroids reduce mortality from alcoholic hepatitis? A meta-analysis of the randomized trials. (2142869)
1990
35
Increased plasma tumor necrosis factor in severe alcoholic hepatitis. (2339855)
1990
36
Alcoholic hepatitis: pathogenesis and approaches to treatment. (2237274)
1990
37
Corticosteroid therapy of alcoholic hepatitis: how many studies will it take? (2205560)
1990
38
Tumor necrosis factor in alcoholic hepatitis. (2777030)
1989
39
Metabolic effects of enteral formula feeding in alcoholic hepatitis. (3119452)
1987
40
Morphometric study of hepatic ultrastructure in alcoholic hepatitis. Veterans Administration Cooperative Study Group on Alcoholic Hepatitis. (2980746)
1987
41
Plasma lipoprotein composition in alcoholic hepatitis: accumulation of apolipoprotein E-rich high density lipoprotein and preferential reappearance of "light'-HDL during partial recovery. (7097121)
1982
42
Double-blind, controlled trial of propylthiouracil in patients with severe acute alcoholic hepatitis. (7037524)
1982
43
Acute alcoholic hepatitis: clinical, biochemical and liver scintiscanning correlation in assessing prognosis. (472544)
1979
44
Hyperalimentation in alcoholic hepatitis. (119434)
1979
45
The role of lecithin:cholesterol acyltransferase deficiency in the apoprotein metabolism of alcoholic hepatitis. (746350)
1978
46
Immunological aspects of alcoholic hepatitis. (95720)
1978
47
Alcoholic hepatitis. (644352)
1978
48
Lymphocyte cytotoxicity in alcoholic hepatitis. (65306)
1977
49
Editorial: Alcoholic hepatitis and corticosteroids. (4751745)
1973
50
Prednisone therapy of acute alcoholic hepatitis. Report of a controlled trial. (4751740)
1973

Variations for Alcoholic Hepatitis

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Expression for genes affiliated with Alcoholic Hepatitis

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Sources:
2BioGPS, 16Gene Expression Omnibus DataSets
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Expression patterns in normal tissues for genes affiliated with Alcoholic Hepatitis

Search GEO for disease gene expression data for Alcoholic Hepatitis.

Pathways for genes affiliated with Alcoholic Hepatitis

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Sources:
51PathCards, 31KEGG, 39NCBI BioSystems Database, 61Thomson Reuters, 56Reactome, 54QIAGEN, 55R&D Systems
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Pathways related to Alcoholic Hepatitis according to GeneCards/GeneDecks:

(show all 34)
idSuper pathways (with members indented)ScoreTop Affiliating Genes
19.5TNF, IL8
29.5IL8, TNF
3
Show member pathways
Calcium signaling in the CD4+ TCR pathway39
9.5IL8, TNF
49.4ICAM1, IL8
5
Show member pathways
9.4ICAM1, IL8
69.3TNF, ICAM1
79.3ICAM1, TNF
8
Show member pathways
9.2IL8, TNF, CYP2E1
9
Show member pathways
9.1IL10, TNF
109.1TNF, IL10
119.1TNF, IL10
12
Show member pathways
IL27-mediated signaling events39
9.1IL10, TNF
139.0ICAM1, IL10
14
Show member pathways
thioredoxin pathway39
9.0F2, ICAM1, TNF
15
Show member pathways
8.9IL8, ICAM1, TNF
168.9IL8, ICAM1, TNF
178.9TNF, IL8, ICAM1
188.9IL8, TNF, ICAM1
198.9ICAM1, TNF, IL8
20
Show member pathways
IL23-mediated signaling events39
Immune response IL 10 signaling pathway61
Angiopoietin receptor Tie2-mediated signaling39
Development PDGF signaling via STATs and NF kB61
Development Angiopoietin Tie2 signaling61
8.8IL10, TNF, F2
21
Show member pathways
Toll-like receptor signaling pathway39
Regulation of toll-like receptor signaling pathway39
8.7TNF, IL8, IL10
228.7TNF, IL8, IL10
238.7IL8, IL10, TNF
248.7IL10, TNF, IL8
258.7IL10, TNF, IL8
26
Show member pathways
8.6IL22, IL10, TNF
27
Show member pathways
8.5ICAM1, IL10, TNF
288.5ICAM1, IL10, TNF
29
Show member pathways
7.7IL22, HGF, IL8, IL10, TNF
30
Show member pathways
7.7TNF, HGF, IL8, IL22, IL10
31
Show member pathways
7.7HGF, TNF, IL10, IL22, IL8
327.6ICAM1, IL8, TNF, IL10, HGF
33
Show member pathways
7.4HGF, TNF, IL22, IL10, IL8, F2
34
Show member pathways
7.4TNF, IL22, IL10, IL8, HGF, F2

Compounds for genes affiliated with Alcoholic Hepatitis

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Sources:
46Novoseek, 12DrugBank, 62Tocris Bioscience, 30IUPHAR, 25HMDB, 52PharmGKB, 3BitterDB
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Compounds related to Alcoholic Hepatitis according to GeneCards/GeneDecks:

(show top 50)    (show all 163)
idCompoundScoreTop Affiliating Genes
1n-tosyl-l-phenylalanine chloromethyl ketone469.3IL8, ICAM1, TNF
2azithromycin46 1210.3IL8, IL10, F2
3staurosporin469.1TNF, ICAM1, IL8
4gabexate mesilate469.1IL8, TNF, IL10
5toxin-1469.1IL10, IL8, TNF
6mip 1alpha469.1IL10, IL8, TNF
7egcg469.0TNF, HGF, CYP2E1, IL8
8il-12469.0TNF, IL10, IL8
95 aminosalicylic acid469.0TNF, IL8, IL10
10diphenyleneiodonium469.0CYP2E1, TNF, ICAM1, IL8
11cdp571468.9IL10, ICAM1, TNF
12imiquimod46 62 30 1211.9TNF, IL8, IL10
13interferon gamma468.9TNF, ICAM1, IL10
14ciglitazone46 309.9IL8, ICAM1, TNF
15hyaluronic acid46 259.9F2, ICAM1, HGF, IL8
16pdtc468.9ICAM1, TNF, HGF, IL8
17aprotinin46 129.8IL10, HGF, IL8, F2
18sp 60012546 629.8IL8, ICAM1, TNF, HGF
19triptolide468.8IL8, ICAM1, TNF
20natalizumab46 129.8TNF, ICAM1, IL10
21mg 13246 629.8IL8, HGF, ICAM1, TNF
22herbimycin a46 629.7TNF, HGF, IL8, ICAM1
23thalidomide46 52 62 1211.7TNF, HGF, IL10, CYP2E1
24go 697646 629.6IL8, TNF, ICAM1
25hydrocortisone46 3 62 1211.6IL8, IL10, HGF, TNF
26ulinastatin468.6TNF, ICAM1, IL10, IL8
27polymyxin b468.5IL10, ICAM1, TNF, IL8
28groalpha468.5IL10, ICAM1, IL8, TNF
29gm-csf46 309.5ICAM1, TNF, IL8, IL10
30n acetylcysteine468.5HGF, IL8, ICAM1, F2, TNF
318-isoprostane468.5IL10, ICAM1, IL8, TNF
32tarc468.5IL8, TNF, ICAM1, IL10
33ccl346 309.5IL8, IL10, ICAM1, TNF
34okt3468.5ICAM1, IL10, TNF
35neopterin468.5TNF, ICAM1, IL10, IL8
36genistein46 30 62 3 25 1213.4HGF, IL8, ICAM1, TNF, CYP2E1
37endotoxin468.3IL8, IL10, ICAM1, TNF
38simvastatin46 52 62 30 25 1213.2F2, TNF, IL8, ICAM1, IL10
39lactate468.2CYP2E1, TNF, ICAM1, F2, IL8, HGF
40pentoxifylline46 129.2IL8, IL10, ICAM1, TNF, CYP2E1
41prostacyclin468.2TNF, ICAM1, HGF, IL10
42h2o2468.2IL8, CYP2E1, ICAM1, TNF, HGF
43histamine46 30 2510.0TNF, ICAM1, IL10, IL8, HGF
44ly294002468.0TNF, HGF, IL8, ICAM1, IL10
45pge2468.0HGF, IL10, ICAM1, IL8, TNF
46oxygen46 258.9IL22, CYP2E1, ICAM1, TNF, IL8, HGF
47cycloheximide467.8TNF, IL10, HGF, IL8, ICAM1
48cyclosporin a46 30 629.7HGF, IL8, IL10, TNF, F2, ICAM1
49sb 20358046 628.7HGF, CYP2E1, TNF, IL8, IL10, ICAM1
50dexamethasone46 52 30 1210.7ICAM1, IL10, IL8, HGF, CYP2E1, TNF

GO Terms for genes affiliated with Alcoholic Hepatitis

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Sources:
17Gene Ontology
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Cellular components related to Alcoholic Hepatitis according to GeneCards/GeneDecks:

idNameGO IDScoreTop Affiliating Genes
1extracellular regionGO:0055768.2HGF, IL8, IL22, TNF, F2
2extracellular spaceGO:0056156.5HGF, F2, TNF, ICAM1, IL22, IL10

Biological processes related to Alcoholic Hepatitis according to GeneCards/GeneDecks:

(show all 20)
idNameGO IDScoreTop Affiliating Genes
1embryonic digestive tract developmentGO:0485669.8TNF, IL8
2acute-phase responseGO:0069539.7F2, IL22
3calcium-mediated signalingGO:0197229.6IL8, TNF
4cellular response to interleukin-1GO:0713479.6IL8, ICAM1
5positive regulation of phosphatidylinositol 3-kinase signalingGO:0140689.6F2, HGF
6response to molecule of bacterial originGO:0022379.5IL8, IL10
7positive regulation of nitric oxide biosynthetic processGO:0454299.5ICAM1, TNF
8receptor biosynthetic processGO:0328009.5IL10, TNF
9regulation of cell adhesionGO:0301559.4IL8, ICAM1
10negative regulation of cytokine secretion involved in immune responseGO:0027409.4TNF, IL10
11negative regulation of growth of symbiont in hostGO:0441309.4IL10, TNF
12positive regulation of peptidyl-tyrosine phosphorylationGO:0507319.4HGF, ICAM1
13negative regulation of interleukin-6 productionGO:0327159.4IL10, TNF
14positive regulation of cytokine secretionGO:0507159.4IL10, TNF
15response to activityGO:0148239.3TNF, IL10
16cellular response to tumor necrosis factorGO:0713569.1IL8, ICAM1
17cellular response to lipopolysaccharideGO:0712228.9ICAM1, IL10, IL8
18response to glucocorticoidGO:0513848.9IL10, IL22, TNF
19inflammatory responseGO:0069548.5IL8, IL10, IL22, TNF
20response to drugGO:0424938.5CYP2E1, TNF, ICAM1, IL10

Molecular functions related to Alcoholic Hepatitis according to GeneCards/GeneDecks:

idNameGO IDScoreTop Affiliating Genes
1cytokine activityGO:0051258.6IL10, IL22, TNF
2growth factor activityGO:0080838.6HGF, IL10, F2

Products for genes affiliated with Alcoholic Hepatitis

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  • Antibodies
  • Proteins
  • Lysates
  • Antibodies

Sources for Alcoholic Hepatitis

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4CDC
14ExPASy
15FMA
23GTR
24HGMD
25HMDB
26ICD10
27ICD10 via Orphanet
28ICD9CM
30IUPHAR
31KEGG
36MeSH
37MESH via Orphanet
38MGI
41NCIt
42NDF-RT
45NINDS
46Novoseek
48OMIM
49OMIM via Orphanet
53PubMed
54QIAGEN
60SNOMED-CT via Orphanet
63UMLS
64UMLS via Orphanet