Alcoholic Hepatitis malady

Wikipedia: Alcoholic hepatitis is hepatitis (inflammation of the liver) due to excessive intake of alcohol. It is...⁴⁴ more...

MalaCards: Alcoholic Hepatitis, also known as acute alcoholic liver disease, is related to alcoholism and autoimmune hepatitis. An important gene associated with Alcoholic Hepatitis is CYP2E1 (cytochrome P450, family 2, subfamily E, polypeptide 1), and among its related pathways are Bacterial infections in CF airways and RAR-Gamma-RXR-Alpha Degradation. The drugs astragalus and astragalus extract and the compounds polyethylene glycol and citrate have been mentioned in the context of this disorder. Affiliated tissues include brain, liver and prostate, and related mouse phenotypes are respiratory system and hematopoietic system.

Aliases & Descriptions:

alcoholic hepatitis 6 8 acute alcoholic liver disease 6 43 acute alcoholic hepatitis 6 32 acute alcoholic liver disease (disorder) 6

alcoholic hepatitis (disorder) 6 hepatitis, alcoholic 43 hepatitis alcoholic 32 hepatitis 43

Diseases related to alcoholic hepatitis by text searches and GeneDecks gene sharing:

(show top 50)    (show all 1117)

id	Related Disease	Score	Top Affiliating Genes
1	alcoholism	36.8	GPT, ALDH2, ALDH9A1, AKR1A1, CYP2E1, TF
2	autoimmune hepatitis	36.5	CD14, FAS, GPT, F2, KRT8, KRT18
3	hepatitis	36.2	FAS, GPT, F2, ALB, TNFRSF1A, CYP2E1
4	hepatitis d	33.6	GPT, F2, TNF, SLC17A5
5	hepatitis e	33.4	GPT, IFNG, F2, ALB, STAT3, SLC17A5
6	fatty liver disease	33.1	CYP2E1, PPARA, SLC17A5
7	colorectal cancer	33.0	GSTM1, ALDH2, TNF, CYP2E1, TLR2, TLR4
8	sepsis	32.3	CD14, IL10, TNF
9	primary biliary cirrhosis	32.0	SELL, GPT, F2, ALB, TLR9, SLC17A5
10	drug-induced hepatitis	31.8	GSTM1, GPT, ALB, CYP2E1, SLC17A5, CP
11	non-a-e hepatitis	31.7	GPT, F2, SLC17A5
12	porphyria cutanea tarda	31.6	BMP6, GSTM1, ALB, CYP2E1, TF, SLC17A5
13	viral hepatitis	30.5	CD14, IL10, IL1A, IL6, FAS, GPT
14	hepatic tuberculosis	30.4	F2, ALB, GGT1
15	immunodeficiency	30.2	SELL, BMP6, CD209, IL10, IL18, IL6
16	portal hypertension	30.0	GPT, F2, ALB, PPP1R12A, NOS3, SLC17A5
17	oral lichen planus	29.9	IL1A, CCL5, ICAM1
18	glycogen storage disease	29.6	VWF, BMP6, IL8, F2, ALB, CRP
19	aplastic anemia	29.5	GSTM1, IL3, FAS, IFNG
20	citrin deficiency	29.5	GPT, F2, SLC17A5
21	cryoglobulinemia	29.4	VWF, BMP6, IL10, IL1B, FAS, CCL2
22	hepatorenal syndrome	29.3	IL18, F2, ALB, TNF
23	malaria	29.3	IL10, IL1A, IFNG, TNF
24	tuberculosis	29.3	CD209, IL10, IL1B, CCL2, IFNG, TNF
25	acute liver failure	29.2	GPT, F2, ALB, SLC17A5, CP, HGF
26	non-hodgkin lymphoma	29.1	SELL, CD14, GSTM1, IL3, FAS, AKR1A1
27	hepatocellular cancer	28.9	BMP6, F2, SPP1, STAT3, HGF
28	arthritis	28.9	SELL, IL1A, IL1B, IL6, IL8, TNF
29	hepatitis a	28.8	IL10, IL1B, GPT, IFNG, F5, F2
30	hemochromatosis	28.8	BMP6, IL6, CCL2, GPT, F5, F2
31	glucose intolerance	28.8	SERPINE1, APOA1, GPT, ALDH2, CRP
32	chronic granulomatous disease	28.8	CD14, IL8, GPT, IFNG, TNF, DUOX1
33	hemolytic anemia	28.8	VWF, TF, CP, ADAMTS13
34	lactic acidosis	28.7	IL10, GPT, F2, ALB, AKR1A1, TNF
35	retinol binding protein	28.4	APOA1, CCL2, ALB, AKR1A1, TNF, PPARA
36	obstructive jaundice	28.4	GPT, AKR1A1, SLC17A5, GGT1
37	pure red-cell aplasia	28.3	IL3, F2, ALB, TF
38	liver cancer	28.1	BMP6, IL6, APOA1, FADD, FAS, CCL5
39	melanoma metastasis	28.1	IL18, IL1B, IL8, F2, TNF
40	polyarteritis nodosa	28.1	IL6, IL8, GPT, CRP
41	cholestasis	28.1	CD14, IL6, GPT, F5, F2, ALB
42	portal vein thrombosis	27.9	SERPINE1, F5, F2, ALB, CRP, PLAT
43	hepatic encephalopathy	27.8	IL18, IL6, GPT, F2, ALB, TNF
44	neonatal intrahepatic cholestasis caused by citrin deficiency	27.8	GPT, F2, SLC17A5
45	wilson disease	27.7	IL1A, IL1B, IL6, FAS, GPT, F2
46	galactosemia	27.7	GPT, F5, F2, ALB, SLC17A5, CP
47	glycogen storage disease type ia	27.5	VWF, IL8, CRP, HGF
48	familial combined hyperlipidemia	27.4	VWF, SERPINE1, APOA1, GPT, TNF, TNFRSF1A
49	alcoholic liver cirrhosis	27.3	GSTM1, IL8, GPT, F2, ALB, ALDH2
50	intrahepatic cholestasis	27.2	GPT, F5, F2, SLC17A5, GGT1

Approved drugs:

Drug clinical trials:

Inferred drug relations via UMLS/NDF-RT:

^43 28 astragalus, astragalus extract

MalaCards organs/tissues related to alcoholic hepatitis:

²²

MGI Mouse Phenotypes related to alcoholic hepatitis:

²⁵ (show all 21)

id	Description	MGI Source Accession	Score	Top Affiliating Genes
1	respiratory system phenotype	MP:0005388	10.5	CD14, SELL
2	hematopoietic system phenotype	MP:0005397	10.0	TLR9, KRT8, TNFRSF14, AKR1A1, IL3, ADAMTS13
3	renal/urinary system phenotype	MP:0005367	9.9	NOS3, PLG, TNFRSF1B, AKR1A1
4	endocrine/exocrine gland phenotype	MP:0005379	9.5	SELL, IFNG, TLR2, GGT1
5	integument phenotype	MP:0010771	9.0	PROS1, TLR4, TLR2, TNFRSF1B, TNFRSF1A, F2
6	nervous system phenotype	MP:0003631	8.5	PLG, TLR2, TLR4, STAT3, PROS1, SLC17A5
7	skeleton phenotype	MP:0005390	8.2	STAT3, PLAT, SPP1, TNFRSF1B, TNFRSF1A, AKR1A1
8	digestive/alimentary phenotype	MP:0005381	8.1	TLR2, KRT8, VWF, ASPH, NOS3, PLG
9	liver/biliary system phenotype	MP:0005370	8.1	TLR4, TLR2, NOS3, PLG, CYP2E1, IFNG
10	reproductive system phenotype	MP:0005389	7.4	SPP1, PLG, KRT8, TLR4, STAT3, TNFRSF1A
11	adipose tissue phenotype	MP:0005375	7.4	PPARA, NOS3, TLR2, TLR4, STAT3, TNFRSF1B
12	growth/size phenotype	MP:0005378	6.8	PLG, NOS3, KRT8, KRT18, TLR4, STAT3
13	vision/eye phenotype	MP:0005391	6.7	PLAT, PLG, NOS3, TLR4, STAT3, SLC17A5
14	muscle phenotype	MP:0005369	6.4	TNFRSF1B, SPP1, PPARA, PLAT, NOS3, TLR2
15	immune system phenotype	MP:0005387	6.3	GGT1, ADAMTS13, STAT3, TLR4, ELANE, KRT8
16	tumorigenesis	MP:0002006	6.0	STAT3, FAS, IL6, IL3, IL1B, IL1A
17	behavior/neurological phenotype	MP:0005386	5.6	TNFRSF1B, CYP2E1, SPP1, PLAT, NOS3, TLR2
18	mortality/aging	MP:0010768	4.8	SERPINE1, VWF, GGT1, ADAMTS13, SLC17A5, PROS1
19	cellular phenotype	MP:0005384	4.4	PLG, PLAT, PPARA, SPP1, TNFRSF1B, TNFRSF1A
20	cardiovascular system phenotype	MP:0005385	3.4	CP, TNFRSF1B, TNFRSF1A, TNF, F2, ICAM1
21	homeostasis/metabolism phenotype	MP:0005376	3.0	NOS3, PLG, PLAT, CRP, PPARA, SPP1

Articles related to alcoholic hepatitis:

(show top 50)    (show all 86)

id	Title	Authors	Year	Affiliating Genes
1	Potential role of enhanced cytokinemia and plasma inh ibitor on the decreased activity of plasma ADAMTS13 in patients with alcoholic hepatitis: relationship to endotoxemia. (19094193)	Ishikawa M.... Fukui H.	2010	VWF, TNF, IL8
2	Lack of association between tumour necrosis factor re ceptor types 1 and 2 gene polymorphism and severe acute alcoholic hepatitis. (19641466)	Nguyen-Khac E.... Naassila M.	2010	TNFRSF1B, TNFRSF1A
3	Serum levels of keratin-18 fragments [tissue polypeptide-specific antigen (TPS)] are correlated with hepatocyte apoptosis in alcoholic hepatitis. (18618253)	Gonzalez-Quintela A.... Lojo S.	2009	KRT18
4	Albumin dialysis improves hepatic encephalopathy and decreases circulating phenolic aromatic amino acids in patients with alcoholic hepatitis and severe liver failure. (19175915)	ParAcs A.... Mas A.	2009	ALB
5	A randomized, double-blinded, placebo-controlled multicenter trial of etanercept in the treatment of alcoholic hepatitis. (18848937)	Boetticher N.C.... Shah V.H.	2008	TNF
6	The -308 TNFalpha gene polymorphism in severe acute alcoholic hepatitis: identification of a new susceptibility marker. (18336639)	Nguyen-Khac E.... Naassila M.	2008	TNF
7	Direct effects of alcohol on hepatic fibrinolytic balance: implications for alcoholic liver disease. (18289715)	Seth D.... Haber P.S.	2008	PLAT, SERPINE1, PLG
8	Hepatic expression of candidate genes in patients with alcoholic hepatitis: correlation with disease severity. (17258719)	Colmenero J.... Gines P.	2007	CYP2E1, DUOX1
9	The Lille model: a new tool for therapeutic strategy in patients with severe alcoholic hepatitis treated with steroids. (17518367)	Louvet A.... Mathurin P.	2007	ALB
10	Serum intercellular adhesion molecule-1 in patients with nonalcoholic steatohepatitis: comparison with alcoholic hepatitis. (17331172)	Ito S.... Yamauchi M.	2007	ICAM1, TNF, CRP
11	Glucocorticoid-induced leucine zipper: A key protein in the sensitization of monocytes to lipopolysaccharide in alcoholic hepatitis. (18046708)	Hamdi H.... Perlemuter G.	2007	TNF
12	Iron overload and cofactors with special reference to alcohol, hepatitis C virus infection and steatosis/insulin resistance. (17729391)	Kohgo Y.... Kato J.	2007	CP
13	Regulation of fat metabolism in the liver: link to non-alcoholic hepatic steatosis and impact of physical exercise. (16649140)	Lavoie J.M.... Gauthier M.S.	2006	PPARA
14	Combined polymorphisms of tumour necrosis factor alpha and interleukin-10 genes in patients with alcoholic hepatitis. (16702858)	Richardet J.P.... Bories P.N.	2006	TNF, IL10
15	Intrahepatic gene expression in human alcoholic hepatitis. (16797773)	Seth D.... Haber P.S.	2006	SPP1, IL8, ANXA2
16	Severe alcoholic hepatitis with extremely high neutrophil count successfully treated by granulocytapheresis. (16508230)	Okubo K.... Kiyosawa K.	2006	F2, IL6, IL8
17	Genetic susceptibility to the development of acute alcoholic hepatitis: role of genetic mutations in dehydrogenase alcohol, aldehyde dehydrogenase and cytochrome P450 2E1 (16324524)	Segado Soriano A.... Gomez-Gallego F.	2005	ALDH2, CYP2E1, AKR1A1
18	Non-alcoholic hepatic steatosis and its relation to increased plasma biomarkers of inflammation and endothelial dysfunction in non-diabetic men. Role of visceral adipose tissue. (16176196)	Targher G.... Falezza G.	2005	SERPINE1
19	Analysis of factors predictive of mortality in alcoholic hepatitis and derivation and validation of the Glasgow alcoholic hepatitis score. (16009691)	Forrest E.H.... Morris A.J.	2005	F2
20	Circulating concentrations of interleukin-18, interleukin-18 binding protein, and gamma interferon in patients with alcoholic hepatitis. (15566508)	Spahr L.... Hadengue A.	2004	IL18, IL18BP
21	Extracorporeal liver support with molecular adsorbents recirculating system in patients with severe acute alcoholic hepatitis. (12480556)	Jalan R.... Williams R.	2003	F2
22	The correlation of Child-Pugh score, PGA index and M ELD score in the patient with liver cirrhosis and hepatocellular carcinoma acco rding to the cause of alcohol and hepatitis B virus (12824750)	Mun B.S.... Lee S.O.	2003	F2, APOA1
23	Anti-tumor necrosis factor-alpha monoclonal antibody therapy in severe alcoholic hepatitis. (12663232)	Tilg H.... Williams R.	2003	TNF
24	Fas-mediated apoptosis in acute alcoholic hepatitis. (12749243)	Tagami A.... Hughes R.D.	2003	FADD
25	Additive inhibition of dendritic cell allostimulatory capacity by alcohol and hepatitis C is not restored by DC maturation and involves abnormal IL-10 and IL-2 induction. (12824825)	Dolganiuc A.... Szabo G.	2003	IL10
26	Why can't Chinese Han drink alcohol? Hepatitis B virus infection and the evolution of acetaldehyde dehydrogenase deficiency. (12208210)	Lin Y.P.... Cheng T.J.	2002	ALDH3A1
27	Corticosteroids improve short-term survival in patients with severe alcoholic hepatitis (AH): individual data analysis of the last three randomized placebo controlled double blind trials of corticosteroids in severe AH. (11943418)	Mathurin P.... Poynard T.	2002	ALB
28	Liver diseases by alcohol and hepatitis C: early detection and new insights in pathogenesis lead to improved treatment. (11268819)	Lieber C.S.	2001	CYP2E1
29	The role of interleukin-10 in severe acute alcoholic hepatitis. (11408022)	TaA^eb J.... Poynard T.	2001	IL10
30	Acute alcoholic hepatitis: treatments (11433695)	Naveau S.	2001	TNF
31	Plasma endotoxin and serum cytokine levels in patients with alcoholic hepatitis: relation to severity of liver disturbance. (10803780)	Fujimoto M.... Fukui H.	2000	IL8, ALB, LBP
32	Pentoxifylline improves short-term survival in severe acute alcoholic hepatitis: a double-blind, placebo-controlled trial. (11113085)	Akriviadis E.... Shakil O.	2000	TNF
33	Hepatocyte cytokeratins are hyperphosphorylated at multiple sites in human alcoholic hepatitis and in a mallory body mouse model. (10623656)	Stumptner C.... Zatloukal K.	2000	KRT8
34	Blood neutrophil functions and cytokine release in severe alcoholic hepatitis: effect of corticosteroids. (10782906)	TaA^eb J.... Chollet-Martin S.	2000	TNF, SELL, IL8
35	Distinct patterns of chemokine expression are associated with leukocyte recruitment in alcoholic hepatitis and alcoholic cirrhosis. (9875144)	Afford S.C.... Adams D.H.	1998	CCL2, IL8, CCL3
36	Hepatocyte proliferation and serum hepatocyte growth factor levels in patients with alcoholic hepatitis. (8738723)	Hillan K.J.... MacSween R.N.	1996	HGF
37	Cytokine levels in acute alcoholic hepatitis: a sequential study. (7587970)	RodrA-guez-RodrA-guez E.... MartA-nez-Riera A.	1995	TNF, IL1B, IFNG
38	Relationships among serum iron status markers, chemical and histochemical liver iron content in 117 patients with alcoholic and non-alcoholic hepatic disease. (8175108)	Milman N.... Pedersen N.S.	1994	TF
39	Increased plasma interleukin-8 concentrations in alcoholic hepatitis. (8359798)	Hill D.B.... McClain C.J.	1993	IL8
40	Circulating and tissue levels of the neutrophil chemotaxin interleukin-8 are elevated in severe acute alcoholic hepatitis, and tissue levels correlate with neutrophil infiltration. (8325620)	Sheron N.... Williams R.	1993	IL8
41	Alcoholic hepatitis. (8465712)	Woods S.E.... Meyer A.	1993	F2, GPT, SLC17A5
42	Coagulation factors V and VIII in relation to severity and outcome in acute alcoholic hepatitis. (1580929)	Pereira L.M.... Williams R.	1992	F2
43	Is the intercellular adhesion molecule-1/leukocyte function associated antigen 1 pathway of leukocyte adhesion involved in the tissue damage of alcoholic hepatitis? (1347281)	Burra P.... Adams D.H.	1992	ICAM1
44	Treatment of severe alcoholic hepatitis by infusion of insulin and glucagon: a multicenter sequential trial. (1727803)	Trinchet J.C.... Labadie H.	1992	F2
45	Alcoholic hepatitis with hyperleukocytosis. (1724989)	Koyama Y.... Kanzaki M.	1991	IL3
46	Elevated plasma interleukin-6 and increased severity and mortality in alcoholic hepatitis. (2044224)	Sheron N.... Williams R.	1991	TNF, F2, IL6
47	Effect of parenteral amino acid supplementation on short-term and long-term outcomes in severe alcoholic hepatitis: a randomized controlled trial. (1959859)	Mezey E.... RodAcs J.	1991	F2, TF, SLC17A5
48	Alcoholic hepatitis: pathogenesis and approaches to treatment. (2237274)	Maddrey W.C.	1990	F2, AKR1A1
49	Hereditary polymorphism of glutathione-S-transferase in the human liver in normal conditions and in alcoholic hepatitis (2227402)	Afanas'eva I.S.... Spitsyn V.A.	1990	GSTM1
50	Prognostic significance of cholestatic alcoholic hepatitis. VA Cooperative Study Group #119. (2364844)	Nissenbaum M.... Gartside P.	1990	F2, SLC17A5

Genes related to alcoholic hepatitis according to GeneCards:

(show top 50)    (show all 68)

id	Symbol	Description	Score	GeneCards Section Context
1	CYP2E1	cytochrome P450, family 2, subfamily E, polypeptide 1	11.0	Publications
2	F2	coagulation factor II (thrombin)	11.0	Publications
3	IL8	interleukin 8	11.0	Publications
4	ICAM1	intercellular adhesion molecule 1	11.0	Publications
5	HGF	hepatocyte growth factor (hepapoietin A; scatter factor)	11.0	Publications
6	TNF	tumor necrosis factor	11.0	Publications
7	IL10	interleukin 10	11.0	Publications
8	NOSIP	nitric oxide synthase interacting protein	11.0
9	TNFRSF14	tumor necrosis factor receptor superfamily, member 14	11.0	Publications
10	PIAS3	protein inhibitor of activated STAT, 3	11.0	Publications
11	IL18BP	interleukin 18 binding protein	11.0	Publications
12	S100A10	S100 calcium binding protein A10	11.0	Publications
13	ALDH3A1	aldehyde dehydrogenase 3 family, member A1	11.0	Publications
14	EXOSC6	exosome component 6	11.0	Publications
15	DUOX1	dual oxidase 1	11.0	Publications
16	ACSS2	acyl-CoA synthetase short-chain family member 2	11.0	Publications
17	ADAMTS13	ADAM metallopeptidase with thrombospondin type 1 motif, 13	11.0	Publications
18	NOSTRIN	nitric oxide synthase trafficker	11.0	Publications
19	LBP	lipopolysaccharide binding protein	11.0	Publications
20	FADD	Fas (TNFRSF6)-associated via death domain	11.0	Publications
21	ANXA2	annexin A2	11.0	Publications
22	AKR1A1	aldo-keto reductase family 1, member A1 (aldehyde reductase)	11.0	Publications
23	CD209	CD209 molecule	11.0	Publications
24	ADH1B	alcohol dehydrogenase 1B (class I), beta polypeptide	11.0	Publications
25	PROS1	protein S (alpha)	11.0	Publications
26	ALDH9A1	aldehyde dehydrogenase 9 family, member A1	11.0	Publications
27	KRT18	keratin 18	11.0	Publications
28	KRT8	keratin 8	11.0	Publications
29	TNFRSF1B	tumor necrosis factor receptor superfamily, member 1B	11.0	Publications
30	TLR9	toll-like receptor 9	11.0	Publications
31	SELL	selectin L	11.0	Publications
32	ASPH	aspartate beta-hydroxylase	11.0
33	TNFRSF1A	tumor necrosis factor receptor superfamily, member 1A	11.0	Publications
34	PLG	plasminogen	11.0	Publications
35	SLC17A5	solute carrier family 17 (anion/sugar transporter), member 5	11.0	Publications
36	SPP1	secreted phosphoprotein 1	11.0	Publications
37	ALDH2	aldehyde dehydrogenase 2 family (mitochondrial)	11.0	Publications
38	PPP1R12A	protein phosphatase 1, regulatory subunit 12A	11.0
39	GPT	glutamic-pyruvate transaminase (alanine aminotransferase)	11.0	Publications
40	CD14	CD14 molecule	11.0	Publications
41	CP	ceruloplasmin (ferroxidase)	11.0	Publications
42	CCL3	chemokine (C-C motif) ligand 3	11.0	Publications
43	CCL5	chemokine (C-C motif) ligand 5	11.0	Publications
44	GGT1	gamma-glutamyltransferase 1	11.0	Publications
45	IL18	interleukin 18 (interferon-gamma-inducing factor)	11.0	Publications
46	F5	coagulation factor V (proaccelerin, labile factor)	11.0	Publications
47	FAS	Fas (TNF receptor superfamily, member 6)	11.0	Publications
48	ALB	albumin	11.0	Publications
49	ELANE	elastase, neutrophil expressed	11.0	Publications
50	SERPINE1	serpin peptidase inhibitor, clade E (nexin, plasminogen activator inhibitor type 1), member 1	11.0	Publications

Pathways related to alcoholic hepatitis according to GeneDecks:

(show top 50)    (show all 116)

id	Pathway	Score	Top Affiliating Genes
1	Bacterial infections in CF airways41	10.6	TLR2, LBP
2	RAR-Gamma-RXR-Alpha Degradation36	10.2	CCL5, CCL3, IL3
3	IL-15 Signaling and its Primary Biological Effects in Different Immune Cell Types37	10.2	TNFRSF1A, CCL3
4	Immune response_Bacterial infections in normal airways41	9.6	LBP, CD14, IL1B, IFNG
5	Immune response Toll-like receptor (TLR) ligands and common TLR signaling pathway leading to cell proinflammatory response10	9.4	CD14, IL6, LBP
6	NFAT Signaling and Lymphocyte Interactions36	9.4	CCL2, IL3, BMP6, IL1A, CCL3
7	Blood Coagulation Signaling Pathways37	9.4	VWF, SERPINE1, PROS1, PLG, PLAT, F5
8	Th1 Differentiation37	9.2	STAT3, IL10, TLR9, TLR4, TLR2, TNF
9	IL-6 Pathway36	9.0	BMP6, PIAS3, IL10, IL18, IL3, HGF
10	Akt Signaling36	9.0	CCL5, TNF, HGF, TNFRSF14, TNFRSF1A, CCL3
11	TRAF Pathway36	9.0	TNFRSF1B, TNF, FADD, IL1B, IL1A, TLR4
12	Cytokine production by Th17 cells in CF41	8.8	CD14, STAT3, TLR4, ICAM1, LBP, IL8
13	Molecular Mechanisms of Cancer36	8.8	TNFRSF1B, HGF, TNFRSF14, FADD, IL6, IL3
14	Regulation of eIF4 and p70S6K36	8.7	CCL3, IL18, IL1A, IL3, IL6, CCL5
15	Amoebiasis20	8.6	IL6, CD14, IL1B, IL8, TLR2, TLR4
16	IL-10 Pathway36	8.5	CD14, STAT3, TLR4, IL10, IL1A, IL1B
17	Immune response_MIF in innate immunity response41	8.4	IL6, IL8, IFNG, TNF, TLR4, IL1B
18	Immune response MIF in innate immunity response10	8.4	IL6, LBP, CD14, IL1B, TLR4, TNF
19	PGC1Alpha Pathway36	8.3	IL3, PPARA, TNFRSF1B, BMP6, IL18, IL1A
20	Toll-like receptor signaling pathway20	8.2	TLR4, TLR2, SPP1, TNF, CCL5, CCL3
21	African trypanosomiasis20	8.2	ICAM1, TNF, TLR9, IL10, IL18, IL1B
22	Rho Family GTPases36	8.1	PPP1R12A, HGF, IL10, IL18, SPP1, CCL5
23	Endothelin-1 Signaling Pathway36	8.1	CCL5, CCL3, IL6, IL3, IL1B, IL18
24	Cytokine Network36	8.0	TNF, IFNG, IL18, IL8, IL1A, IL1B
25	Pertussis20	8.0	TNF, TLR4, IL1B, CD14, IL1A, IL10
26	IL-21 Signaling and its Primary Biological Effects in Different Immune Cell Types37	8.0	TLR2, IFNG, IL6, IL1B, TLR9, STAT3
27	Malaria20	7.8	IL10, HGF, IL18, IL1B, IL6, IL8
28	PEDF Induced Signaling36	7.7	IL1B, BMP6, IL10, IL1A, IL3, IL6
29	ERK Signaling36	7.7	SPP1, PPP1R12A, CCL5, CCL3, IL6, IL3
30	all-trans-Retinoic Acid Signaling in Brain36	7.7	BMP6, HGF, TNF, CCL5, IL10, IL18
31	NF-KappaB (p50-p65) Pathway36	7.6	IL1B, IL1A, TLR4, BMP6, HGF, IL6
32	NF-KappaB Family Pathway36	7.6	IL6, TNFRSF1A, IL3, TNF, IL1B, TNFRSF1B
33	Tec Kinases Signaling36	7.6	CCL2, CCL3, CCL5, TNFRSF14, TNFRSF1B, TLR2
34	Glucocorticoid Receptor Signaling36	7.5	TNFRSF1B, CCL2, TNFRSF1A, CCL5, CCL3, IL8
35	SOCS Pathway36	7.5	BMP6, CCL5, IL10, IL18, IL1A, IL1B
36	Measles20	7.5	IL1B, IL6, IFNG, TLR2, TLR9, TLR4
37	TGF-Beta Pathway36	7.5	CCL5, IL3, BMP6, HGF, TNFRSF1B, TNFRSF1A
38	Tuberculosis20	7.5	CD14, IL10, IL18, IL1A, IL1B, IL6
39	PAK Pathway36	7.4	IL10, IL18, IL1A, IL1B, IL3, BMP6
40	Rheumatoid arthritis20	7.4	IL6, IL8, CCL2, CCL3, CCL5, IFNG
41	MAPK Family Pathway36	7.4	BMP6, CCL5, TNF, CCL3, TNFRSF1A, TNFRSF1B
42	Influenza A20	7.4	IFNG, CCL5, CCL2, FAS, IL8, IL6
43	MIF Regulation of Innate Immune Cells36	7.4	CD14, BMP6, IL10, IL18, IL1A, HGF
44	MIF Mediated Glucocorticoid Regulation36	7.4	HGF, TLR4, TNF, CCL5, CCL3, CCL2
45	Antioxidant Action of Vitamin-C36	7.3	TNF, TNFRSF1A, CCL2, TNFRSF1B, HGF, IL6
46	p38 Signaling36	7.3	TNF, IL1A, IL3, IL6, IL8, CCL2
47	Chagas disease (American trypanosomiasis)20	7.2	TLR9, TLR4, TLR2, SERPINE1, IL10, TNFRSF1A
48	STAT3 Pathway36	7.2	BMP6, TNFRSF1B, STAT3, HGF, TNFRSF1A, TNFRSF14
49	Cytokine-cytokine receptor interaction20	7.0	IL18, IL1A, IL1B, IL3, IL6, IL8
50	JAK-STAT Pathway36	6.7	PIAS3, BMP6, IL10, IL18, IL1A, IL1B

Compounds related to alcoholic hepatitis according to GeneDecks:

(show top 50)    (show all 437)

id	Compound	Score	Top Affiliating Genes
1	polyethylene glycol32	10.4	SPP1, APOA1
2	citrate32	10.2	NOS3, PPARA, AKR1A1
3	hyaluronic acid32 18	10.9	GGT1, SLC17A5, ELANE, F2, GPT, BMP6
4	n acetylcysteine32	9.3	F2, GPT, IL3, IL18, VWF, PLG
5	groalpha32	9.2	IL10, TNF, ICAM1, CCL5, CCL3, CCL2
6	ethanol32 34 9 18 9	13.2	SLC17A5, CD14, IL18, ACSS2, KRT18, KRT8
7	ascorbic acid32 18	10.1	IL3, IL1A, GSTM1, FAS, CYP2E1, SLC17A5
8	acetaldehyde32 18	10.1	PPARA, CYP2E1, AKR1A1, ALDH9A1, ALDH3A1, ALDH2
9	phenobarbital32 9 9	10.8	HGF, CP, SLC17A5, TF, PPARA, CYP2E1
10	aspartate32	8.6	GGT1, HGF, SLC17A5, STAT3, PPARA, ALDH9A1
11	polyinosinic-polycytidylic acid32	8.4	IL8, IL6, IL18, IL10, CCL3, IFNG
12	imiquimod32 42 9 9	11.4	TLR4, TNF, IFNG, IL8, IL6, IL1A
13	estrogen32	8.2	ELANE, KRT18, KRT8, NOS3, PPARA, AKR1A1
14	polysaccharide32	8.2	HGF, TF, TLR4, TLR2, ICAM1, F5
15	triptolide32	8.2	CCL5, CCL3, CCL2, IL8, IL6, IL1B
16	lipoteichoic acid32	8.1	TLR9, TLR4, TLR2, TNF, CCL3, CCL2
17	thalidomide32 42 9 9	10.8	HGF, STAT3, PLG, CYP2E1, TNFRSF1B, TNFRSF1A
18	cysteine32	7.7	CP, ELANE, FADD, GSTM1, CD14, ANXA2
19	fluvastatin32 34 9 9	10.7	PPARA, CCL2, APOA1, IL6, IL1A, SERPINE1
20	testosterone32 9 18 9	10.6	TNFRSF1B, TNFRSF1A, ALDH9A1, F5, CCL3, FAS
21	poly(i-c)32	7.6	CCL5, CCL3, IL8, IL6, IL3, IL1B
22	h2o232	7.5	ICAM1, CCL5, APOA1, IL3, IL18, SELL
23	folate32	7.5	F5, CCL5, IL18, GSTM1, VWF, ALB
24	troglitazone32 42 9 9	10.5	ICAM1, GPT, CCL2, IL8, IL6, IL1B
25	vitamin a32 9 18 9	10.4	ELANE, CRP, PPARA, CYP2E1, AKR1A1, ALDH9A1
26	sb 20358032 42	8.4	CRP, SPP1, CYP2E1, TNF, IFNG, CCL5
27	pentoxifylline32 9 9	9.4	IFNG, IL8, IL6, IL1B, IL1A, IL18
28	15-deoxy-delta-12,14-prostaglandin j232	7.3	IFNG, CCL2, IL8, IL6, IL1B, IL10
29	homocysteine32 18	8.2	ANXA2, APOA1, IL18, CD14, LBP, SERPINE1
30	ly29400232	7.2	ICAM1, CCL5, CCL3, CCL2, IL8, IL6
31	superoxide32 18	8.2	HGF, ALDH2, CCL2, ANXA2, IL8, IL1B
32	histamine32 18	8.0	AKR1A1, VWF, ALDH2, ALB, ICAM1, CCL5
33	tacrolimus32 34 9 9	10.0	CCL5, CCL3, APOA1, IL3, IL18, IL10
34	herbimycin a32 42	8.0	HGF, SPP1, TNFRSF1A, TNF, ICAM1, IFNG
35	hydrocortisone32 9 9	8.8	IL8, IL6, IL3, IL1B, IL1A, IL10
36	glutamine32	6.7	GGT1, HGF, CP, SLC17A5, TF, TLR2
37	norepinephrine32 9 18 9	9.7	HGF, SLC17A5, TF, ELANE, CRP, PPARA
38	il 1032	6.5	TLR4, TLR2, TNFRSF1B, TNF, IFNG, CCL5
39	prednisolone32 9 9	8.5	IFNG, GPT, CCL3, FAS, IL6, IL18
40	methotrexate32 34 42 9 9	10.3	TNFRSF1A, TNF, ALB, F2, GPT, CCL5
41	pd 98,05932	6.2	STAT3, TLR2, NOS3, SPP1, TNF, ICAM1
42	vitamin d32	5.6	SPP1, BMP6, SERPINE1, CD14, GSTM1, TNFRSF1B
43	creatinine32	5.4	GGT1, HGF, ADAMTS13, CP, PROS1, TF
44	lipid32	5.0	PLG, CRP, PPARA, SPP1, CYP2E1, TNFRSF1B
45	actinomycin d32	4.7	HGF, STAT3, TLR4, TLR2, KRT18, KRT8
46	lactate32	4.5	GGT1, HGF, CP, SLC17A5, TF, TLR4
47	alanine32	4.4	IL18, CD14, LBP, BMP6, SELL, VWF
48	cholesterol32 9 18 9	7.3	GGT1, CP, SLC17A5, PROS1, STAT3, TF
49	dexamethasone32 42 34 9 9	7.7	SERPINE1, SELL, VWF, BMP6, GGT1, HGF
50	retinoic acid32 42 18	5.0	CD14, BMP6, SERPINE1, SELL, VWF, IL18

Cellular components related to alcoholic hepatitis according to GeneDecks:

id	Name	GO ID	Score	Top Affiliating Genes
1	membrane raft	GO:045121	9.6	TLR4, TNFRSF1B, TNFRSF1A, TNF, FAS, FADD
2	platelet alpha granule lumen	GO:031093	9.6	HGF, PROS1, PLG, ALB, F5, SERPINE1
3	external side of plasma membrane	GO:009897	9.0	TLR4, TLR2, TNFRSF14, TNF, ICAM1, IFNG
4	secretory granule	GO:030141	8.7	TF, ELANE, PLAT, APOA1, IL1B
5	cell surface	GO:009986	8.6	ADAMTS13, TLR2, ELANE, PLAT, TNFRSF1A, TNF
6	plasma membrane	GO:005886	7.3	TNFRSF14, TNFRSF1A, TNFRSF1B, PLG, NOS3, NOSTRIN
7	extracellular space	GO:005615	4.1	HGF, APOA1, IL8, IL6, IL3, IL1B
8	extracellular region	GO:005576	3.4	HGF, CP, VWF, FAS, APOA1, IL8

Biological processes related to alcoholic hepatitis according to GeneDecks:

(show top 50)    (show all 92)

id	Name	GO ID	Score	Top Affiliating Genes
1	negative regulation of interleukin-6 production	GO:032715	10.4	TNFRSF1A, TLR9, IL10, TNF, TLR4
2	cellular response to lipoteichoic acid	GO:071223	10.2	TLR4, CD14, TLR2, LBP
3	cellular response to interleukin-1	GO:071347	10.2	CCL5, IL8, ICAM1, CCL2, CCL3
4	response to activity	GO:014823	10.1	TLR4, TNF, IL10, CCL5, CCL2
5	positive regulation of cytokine secretion	GO:050715	10.1	IL10, CD14, TLR2, IL1A, TNF
6	cellular response to tumor necrosis factor	GO:071356	10.0	IL18, CCL2, IL8, CCL5, ICAM1, IL18BP
7	positive regulation of nitric-oxide synthase biosynthetic process	GO:051770	10.0	TLR4, TLR9, TLR2, CCL2
8	fibrinolysis	GO:042730	10.0	SERPINE1, F2, PLAT, PLG, PROS1
9	cellular response to interferon-gamma	GO:071346	9.9	IL18, CCL2, CCL3, CCL5
10	response to amino acid stimulus	GO:043200	9.8	NOS3, TNFRSF1A, ICAM1, CCL2
11	negative regulation of cytokine secretion involved in immune response	GO:002740	9.8	IL10, APOA1, TNF
12	negative regulation of growth of symbiont in host	GO:044130	9.8	IFNG, TNF, ELANE, TLR2, LBP, IL10
13	positive regulation of NF-kappaB import into nucleus	GO:042346	9.8	IL1B, TNF, TLR2, TLR4, TLR9
14	regulation of sensory perception of pain	GO:051930	9.7	IL1A, CCL3, TLR4, IL10
15	positive regulation of inflammatory response	GO:050729	9.7	TLR4, TLR2, IL18, TLR9, SERPINE1, CCL3
16	protein kinase B signaling cascade	GO:043491	9.7	CCL5, CCL3, CCL2, IL1B, TNF
17	response to lipopolysaccharide	GO:032496	9.7	FAS, IL1A, ELANE, IL18BP, LBP, TLR4
18	positive regulation of calcidiol 1-monooxygenase activity	GO:060559	9.6	TNF, IFNG, IL1B
19	response to ethanol	GO:045471	9.6	CCL2, ICAM1, TNFRSF1A, NOS3, STAT3, TLR4
20	cellular response to mechanical stimulus	GO:071260	9.6	IL18, IL1B, FADD, TNFRSF1A, TLR4, FAS
21	cellular response to organic cyclic compound	GO:071407	9.6	IL1B, CCL2, CCL3, CCL5, TNF, IL18
22	positive regulation of membrane protein ectodomain proteolysis	GO:051044	9.6	IFNG, TNF, TNFRSF1B, IL1B
23	MAPK cascade	GO:000165	9.5	CCL3, IL18, IL1B, TNF, CCL5, CCL2
24	platelet degranulation	GO:002576	9.4	PLG, TF, SERPINE1, APOA1, ALB, PROS1
25	monocyte chemotaxis	GO:002548	9.4	IL6, CCL5, CCL3, CCL2
26	positive regulation of JNK cascade	GO:046330	9.4	TLR9, IL1B, IL1A, TNF, TLR4
27	positive regulation of interleukin-8 production	GO:032757	9.3	TLR9, TLR4, TLR2, FADD, IL1B, SERPINE1
28	defense response to Gram-negative bacterium	GO:050829	9.3	IL6, LBP, TLR4, SERPINE1
29	positive regulation of interleukin-12 production	GO:032735	9.3	TLR9, TLR4, IFNG, TLR2
30	positive regulation of nitric oxide biosynthetic process	GO:045429	9.3	IL1B, ICAM1, TNF, TLR4, IFNG, TLR2
31	positive regulation of I-kappaB kinase/NF-kappaB cascade	GO:043123	9.3	TLR4, IL1A, TLR9, TNFRSF1A, TNF, FADD
32	cellular response to lipopolysaccharide	GO:071222	9.3	CD14, IFNG, SERPINE1, LBP, CCL2, IL8
33	neutrophil chemotaxis	GO:030593	9.3	IL1B, CCL2, IL8, IFNG, CCL3, SPP1
34	positive regulation of chemokine production	GO:032722	9.3	TLR4, TLR2, IL6, IL18, LBP, TNF
35	positive regulation of angiogenesis	GO:045766	9.2	NOS3, TNFRSF1A, CCL5, IL1B, IL1A, SERPINE1
36	positive regulation of tumor necrosis factor production	GO:032760	9.2	CD14, LBP, IL18, FADD, CCL3, TNFRSF1A
37	aging	GO:007568	9.1	FAS, NOS3, CCL2, CCL5, IL1B, ALDH3A1
38	response to drug	GO:042493	9.1	STAT3, CCL2, IL10, FAS, CCL5, IFNG
39	anti-apoptosis	GO:006916	9.1	IL10, IL1A, FAS, CCL2, NOS3, HGF
40	acute-phase response	GO:006953	9.0	LBP, IL6, STAT3, CRP, F2
41	lipopolysaccharide-mediated signaling pathway	GO:031663	8.9	IL18, IL1B, CCL2, CCL3, CCL5, TNF
42	positive regulation of NF-kappaB transcription factor activity	GO:051092	8.8	TNF, TLR9, ICAM1, IL6, IL1B, TLR4
43	positive regulation of interleukin-6 production	GO:032755	8.6	IL1A, IL1B, IL6, TLR4, TLR9, TLR2
44	blood coagulation	GO:007596	8.5	HGF, TF, NOS3, PLG, PLAT, ALB
45	platelet activation	GO:030168	8.5	IL6, APOA1, F5, F2, ALB, SERPINE1
46	response to glucocorticoid stimulus	GO:051384	8.2	PLAT, FAS, CCL2, TNF, ALDH3A1, CCL5
47	cytokine-mediated signaling pathway	GO:019221	8.0	CCL2, IFNG, ICAM1, TNFRSF1A, DUOX1, IL6
48	response to hypoxia	GO:001666	7.3	CCL2, TLR4, NOS3, PLAT, CRP, PPARA
49	inflammatory response	GO:006954	6.7	BMP6, IL1B, TLR9, CRP, SPP1, TNFRSF1B
50	positive regulation of transcription from RNA polymerase II promoter	GO:045944	6.7	SERPINE1, STAT3, TLR9, IFNG, TNF, TNFRSF1A

Molecular functions related to alcoholic hepatitis according to GeneDecks:

(show all 12)

id	Name	GO ID	Score	Top Affiliating Genes
1	cell surface binding	GO:043498	10.3	LBP, ICAM1, PLG
2	tumor necrosis factor-activated receptor activity	GO:005031	10.2	TNFRSF1B, TNFRSF1A, TNFRSF14, FAS
3	lipoteichoic acid binding	GO:070891	10.2	LBP, CD14, TLR2
4	CCR5 chemokine receptor binding	GO:031730	10.0	STAT3, CCL5, CCL3
5	lipopolysaccharide binding	GO:001530	10.0	LBP, CD14, TLR4
6	protease binding	GO:002020	9.9	ELANE, TNFRSF1A, TNF, SERPINE1, SELL, VWF
7	Gram-positive bacterial cell surface binding	GO:051637	9.7	TLR2, CRP, LBP
8	chemokine activity	GO:008009	9.6	CCL5, CCL3, CCL2, IL8
9	interleukin-1 receptor binding	GO:005149	9.5	TLR9, IL1B, IL1A
10	growth factor activity	GO:008083	8.5	HGF, F2, IL6, IL3, IL1B, IL10
11	cytokine activity	GO:005125	7.5	SPP1, TNF, IFNG, IL6, IL3, IL1B
12	protein binding	GO:005515	4.4	GGT1, NOSIP, NOS3, PLG, PLAT, CRP