MCID: ALC006
MIFTS: 62

Alcoholic Hepatitis

Categories: Gastrointestinal diseases, Liver diseases

Aliases & Classifications for Alcoholic Hepatitis

MalaCards integrated aliases for Alcoholic Hepatitis:

Name: Alcoholic Hepatitis 37 12 72 14
Acute Alcoholic Liver Disease 12 69
Acute Alcoholic Hepatitis 12 51
Hepatitis, Alcoholic 69
Hepatitis Alcoholic 51

Classifications:



External Ids:

Disease Ontology 12 DOID:12351
ICD9CM 34 571.1
NCIt 46 C34352
SNOMED-CT 64 155810001 9953008
ICD10 32 K70.1

Summaries for Alcoholic Hepatitis

MalaCards based summary : Alcoholic Hepatitis, also known as acute alcoholic liver disease, is related to hepatitis and hepatitis a. An important gene associated with Alcoholic Hepatitis is F2 (Coagulation Factor II, Thrombin), and among its related pathways/superpathways are TGF-Beta Pathway and Cytokine Signaling in Immune system. The drugs Caspofungin and Miconazole have been mentioned in the context of this disorder. Affiliated tissues include liver, brain and t cells, and related phenotypes are liver/biliary system and neoplasm

Wikipedia : 72 Alcoholic hepatitis is hepatitis (inflammation of the liver) due to excessive intake of alcohol. It is... more...

Related Diseases for Alcoholic Hepatitis

Diseases related to Alcoholic Hepatitis via text searches within MalaCards or GeneCards Suite gene sharing:

(show top 50) (show all 311)
# Related Disease Score Top Affiliating Genes
1 hepatitis 31.5 F2 GPT SLC17A5 TNF
2 hepatitis a 30.6 ALB F2 GPT TNF
3 fatty liver disease 30.5 CYP2E1 GPT IL6 KRT18 SLC17A5 TNF
4 hepatic coma 29.7 ALB F2 GPT
5 hepatitis e 29.7 ALB F2 GPT TNF
6 portal hypertension 29.6 ALB F2 GPT TNF
7 hepatitis b 29.6 ALB F2 GPT SLC17A5 TNF
8 alcohol abuse 29.5 CYP2E1 GPT SLC17A5
9 acute pancreatitis 29.4 CXCL8 IL10 IL6
10 acute liver failure 29.4 ALB F2 GPT SLC17A5
11 prostatitis 29.4 CXCL8 IL10 IL6 TNF
12 protein-energy malnutrition 29.4 ALB GPT IL6 TNF
13 alcoholic liver cirrhosis 29.2 ALB CXCL8 CYP2E1 F2 SLC17A5 TNF
14 nonalcoholic steatohepatitis 29.2 F2 GPT IL6 KRT18 SLC17A5 TNF
15 hepatic encephalopathy 29.2 ALB F2 GPT IL6 SLC17A5 TNF
16 pneumonia 28.9 CCL2 CXCL8 IL10 IL6 TNF
17 liver disease 28.7 ALB CYP2E1 F2 GPT IL6 KRT18
18 liver cirrhosis 28.6 ALB CYP2E1 F2 GPT KRT18 SLC17A5
19 viral hepatitis 28.6 ALB F2 GPT KRT18 SLC17A5 TNF
20 hepatocellular carcinoma 28.4 ALB CXCL8 CYP2E1 F2 IL6 KRT18
21 peritonitis 27.2 ALB CCL2 CXCL8 F2 ICAM1 IL10
22 antipyrine metabolism 10.6 ALB F2
23 scorpion envenomation 10.6 IL6 TNF
24 non-a-e hepatitis 10.6 ALB F2
25 marburg hemorrhagic fever 10.5 F2 TNF
26 angioimmunoblastic lymphadenopathy with dysproteinemia 10.5 IL6 TNF
27 critical limb ischemia 10.5 IL6 TNF
28 recurrent corneal erosion 10.5 CXCL8 IL6
29 bagassosis 10.5 CXCL8 IL6
30 sudden sensorineural hearing loss 10.5 F2 IL6
31 fournier gangrene 10.5 ALB F2
32 toxicodendron dermatitis 10.5 CXCL8 ICAM1
33 null-cell leukemia 10.4 IL6 TNF
34 streptococcal toxic-shock syndrome 10.4 CXCL8 IL6 TNF
35 abdominal tuberculosis 10.4 ALB F2
36 meconium aspiration syndrome 10.4 CXCL8 IL6 TNF
37 louse-borne relapsing fever 10.4 CXCL8 IL6 TNF
38 punctate inner choroidopathy 10.4 IL10 TNF
39 paraquat poisoning 10.4 GPT SLC17A5
40 hepatoportal sclerosis 10.4 F2 GPT
41 pulpitis 10.4 CXCL8 IL6 TNF
42 perinatal necrotizing enterocolitis 10.4 CXCL8 IL6 TNF
43 fasciitis 10.4 CXCL8 IL6 TNF
44 acute respiratory distress syndrome 10.4 CXCL8 IL6 TNF
45 endometritis 10.4 IL6 SLC17A5 TNF
46 uterine anomalies 10.4 CXCL8 IL6 TNF
47 leukomalacia 10.4 IL6 SLC17A5 TNF
48 tropical endomyocardial fibrosis 10.4 IL10 TNF
49 avian influenza 10.4 CXCL8 IL6 TNF
50 pulmonary disease, chronic obstructive 10.4 CXCL8 IL6 TNF

Comorbidity relations with Alcoholic Hepatitis via Phenotypic Disease Network (PDN): (show all 12)


Active Peptic Ulcer Disease Acute Cystitis
Acute Pancreatitis Alcohol Abuse
Alcoholic Gastritis Alcoholic Liver Cirrhosis
Alcoholic Neuropathy Deficiency Anemia
Fatty Liver Disease Hepatic Encephalopathy
Portal Hypertension Protein-Energy Malnutrition

Graphical network of the top 20 diseases related to Alcoholic Hepatitis:



Diseases related to Alcoholic Hepatitis

Symptoms & Phenotypes for Alcoholic Hepatitis

MGI Mouse Phenotypes related to Alcoholic Hepatitis:

43
# Description MGI Source Accession Score Top Affiliating Genes
1 liver/biliary system MP:0005370 9.5 ALB CYP2E1 IL10 IL6 KRT18 LBP
2 neoplasm MP:0002006 9.1 ALB CYP2E1 ICAM1 IL10 IL6 TNF

Drugs & Therapeutics for Alcoholic Hepatitis

Drugs for Alcoholic Hepatitis (from DrugBank, HMDB, Dgidb, PharmGKB, IUPHAR, NovoSeek, BitterDB):

(show top 50) (show all 135)
# Name Status Phase Clinical Trials Cas Number PubChem Id
1
Caspofungin Approved Phase 4 162808-62-0, 179463-17-3 2826718 468682
2
Miconazole Approved, Investigational, Vet_approved Phase 4 22916-47-8 4189
3
Pentoxifylline Approved, Investigational Phase 4,Phase 3,Phase 2,Phase 1 6493-05-6 4740
4
Lenograstim Approved, Investigational Phase 4,Phase 3,Phase 2 135968-09-1
5
Ethanol Approved Phase 4,Phase 3,Phase 2,Phase 1 64-17-5 702
6
Prednisone Approved, Vet_approved Phase 4,Phase 2 53-03-2 5865
7
Octreotide Approved, Investigational Phase 4 83150-76-9 6400441 383414
8
Somatostatin Approved, Investigational Phase 4 38916-34-6, 51110-01-1 53481605
9
Acetylcysteine Approved, Investigational Phase 4,Phase 3 616-91-1 12035
10
Metformin Approved Phase 4 657-24-9 4091 14219
11
Choline Approved, Nutraceutical Phase 4 62-49-7 305
12
Folic Acid Approved, Nutraceutical, Vet_approved Phase 4,Phase 2 59-30-3 6037
13
Pyridoxal Approved, Nutraceutical Phase 4,Phase 2 66-72-8 1050
14
Pyridoxine Approved, Investigational, Nutraceutical, Vet_approved Phase 4,Phase 2 65-23-6 1054
15
Vitamin C Approved, Nutraceutical Phase 4 50-81-7 54670067 5785
16 Antimetabolites Phase 4
17 Gastrointestinal Agents Phase 4,Phase 3,Phase 2,Early Phase 1
18 Hypolipidemic Agents Phase 4
19 Lipid Regulating Agents Phase 4
20 Nootropic Agents Phase 4
21 Polyene phosphatidylcholine Phase 4
22 Liver Extracts Phase 4,Phase 3,Phase 2,Phase 1,Early Phase 1
23 Antifungal Agents Phase 4
24 Anti-Infective Agents Phase 4,Phase 3,Phase 2,Early Phase 1
25 Echinocandins Phase 4
26 Anti-Inflammatory Agents Phase 4,Phase 3,Phase 2,Early Phase 1
27 Antineoplastic Agents, Hormonal Phase 4,Phase 3,Phase 2,Early Phase 1
28 Antioxidants Phase 4,Phase 3,Phase 2,Phase 1
29 glucocorticoids Phase 4,Phase 3,Phase 2,Early Phase 1
30 Hormone Antagonists Phase 4,Phase 3,Phase 2,Early Phase 1
31 Hormones Phase 4,Phase 3,Phase 2,Early Phase 1
32 Hormones, Hormone Substitutes, and Hormone Antagonists Phase 4,Phase 3,Phase 2,Early Phase 1
33 Phosphodiesterase Inhibitors Phase 4,Phase 3,Phase 2,Phase 1
34 Platelet Aggregation Inhibitors Phase 4,Phase 3,Phase 2,Phase 1
35 Protective Agents Phase 4,Phase 3,Phase 2,Phase 1,Early Phase 1
36 Radiation-Protective Agents Phase 4,Phase 3,Phase 2,Phase 1
37 Vasodilator Agents Phase 4,Phase 3,Phase 2,Phase 1
38 Adjuvants, Immunologic Phase 4,Phase 3,Phase 2
39 Anti-Bacterial Agents Phase 4,Phase 3,Phase 2,Early Phase 1
40 Metadoxine Phase 4,Phase 2
41 Micronutrients Phase 4,Phase 3,Phase 2
42 Trace Elements Phase 4,Phase 3,Phase 2
43 Vitamin B 6 Phase 4,Phase 2
44 Vitamin B Complex Phase 4,Phase 2
45 Vitamins Phase 4,Phase 3,Phase 2
46 Anti-Infective Agents, Local Phase 4
47 Central Nervous System Depressants Phase 4
48 Antibiotics, Antitubercular Phase 4,Phase 2,Phase 3
49 Antidotes Phase 4,Phase 3
50 Antiviral Agents Phase 4,Phase 3

Interventional clinical trials:

(show top 50) (show all 80)

# Name Status NCT ID Phase Drugs
1 Efficacy and Safety of S-adenosyl-l-methionine in Treatment of Alcoholic Hepatitis With Cholestasis Unknown status NCT02024295 Phase 4 Ademethionine;Polyene Phosphatidyl choline;Ademethionine
2 Effect of Probiotics on Gut-Liver Axis of Alcoholic Hepatitis Unknown status NCT02335632 Phase 4 Probiotics (Lacidofil®);Placebo
3 Pharmacokinetics of Caspofungin After One Dose in Patients With Liver Failure Unknown status NCT01968395 Phase 4 Caspofungin 70 mg
4 Metadoxine as a Therapy for Severe Alcoholic Hepatitis Completed NCT02161653 Phase 4 Prednisone plus Metadoxine;Pentoxifylline plus Metadoxine
5 The Effect of High Dose Vitamin C on the Liver Function in Chronic Hepatitis Patients Completed NCT01413360 Phase 4 High dose vitamin C
6 Somatostatin, Octreotide, Pentoxyfilline in the Prevention of Post-ERCP Pancreatitis and Molecular Markers Completed NCT00222092 Phase 4
7 Effect of Probiotics on Gut-Liver Axis of Alcoholic Liver Disease Completed NCT01501162 Phase 4 hepatitis, alcohol, probiotics;alcohol, hepatitis, Placebo
8 G-CSF Plus NAC In Severe Alcoholic Hepatitis Recruiting NCT02971306 Phase 4 standard medical therapy;G-CSF;n-Acetylcysteine
9 Effect of Metadoxine on Oxidative Stress in Non-alcoholic Hepatic Steatosis Recruiting NCT02051842 Phase 4 Metadoxine
10 Rifaximin Use in Severe Alcoholic Hepatitis Unknown status NCT02485106 Phase 3 Rifaximin;Corticosteroid or pentoxifylline
11 Short-term Survival in Patients With Severe Alcoholic Hepatitis Treated With Steroid Versus Pentoxifylline Unknown status NCT01455337 Phase 3 pentoxifylline;Prednisolone
12 Probiotics for Portal Hypertension Unknown status NCT01134692 Phase 3 Propranolol, Norfloxacin, VSL#3
13 N-Acetylcysteine in Severe Acute Alcoholic Hepatitis Completed NCT00962442 Phase 3 N-Acetylcysteine;placebo
14 Treatment of Severe Alcoholic Hepatitis With Corticoids Plus N Acetyl Cysteine Versus Corticoids Alone Completed NCT00863785 Phase 3 Corticoids plus N Acetyl Cysteine
15 Double-blind Randomized Controlled Trial in Severe Alcoholic Hepatitis Completed NCT01214226 Phase 3 Pentoxifylline;placebo
16 Assess Safety and Efficacy of ELAD (Extracorporeal Liver Assist System) in Subjects With Alcohol-Induced Liver Failure Completed NCT01471028 Phase 3
17 Trial for Hepatocellular Carcinoma Adjuvant Treatment by Lipiocis Completed NCT00116454 Phase 3 131 I-lipiodol
18 Efficacy and Safety of the Extracorporeal Liver Assist Device (ELAD) in Acute on Chronic Hepatitis Completed NCT00973817 Phase 2, Phase 3
19 Efficacy of Granulocyte Colony-stimulating Factor and Erythropoetin for Patients With Acute-on-chronic Liver Failure Completed NCT01383460 Phase 3 Granulocyte Colony-stimulating Factor (G-CSF) and Erythropoetin (EPO);Placebo
20 Granulocyte Colony Stimulating Factor And Growth Hormone In Cirrhosis Of Liver: An Open Label Study Completed NCT02451033 Phase 2, Phase 3 standard medical therapy;G-CSF;Growth Hormone
21 A Placebo-Controlled, Double-Blind Study to Confirm the Reversal of Hepatorenal Syndrome Type 1 With Terlipressin Completed NCT01143246 Phase 3 Terlipressin;Placebo
22 Efficacy and Safety of G-CSF in Patients With Severe Alcoholic Hepatitis With Null or Partial Response to Steroid Recruiting NCT02442180 Phase 3 G-CSF (Filgrastim injection);steroid;placebo
23 Comparison of Bovine Colostrum Versus Placebo in Treatment of Severe Alcoholic Hepatitis: A Randomized Double Blind Controlled Trial Recruiting NCT02473341 Phase 3 Bovine Colostrum;Placebo
24 Efficacy of Antibiotic Therapy in Severe Alcoholic Hepatitis Treated With Prednisolone Recruiting NCT02281929 Phase 3 Amoxicillin;Placebo;Prednisolone
25 Efficacy Study of Anakinra, Pentoxifylline, and Zinc Compared to Methylprednisolone in Severe Acute Alcoholic Hepatitis Recruiting NCT01809132 Phase 2, Phase 3 Anakinra;Pentoxifylline;Zinc Sulfate;Methylprednisolone
26 N-ACetylcysteine to Reduce Infection and Mortality for Alcoholic Hepatitis Recruiting NCT03069300 Phase 3 N-acetyl cysteine (NAC)
27 Randomized, Open-Label, Multicenter, Controlled, Pivotal Study to Assess Safety and Efficacy of ELAD in Subjects w/ AILD Recruiting NCT02612428 Phase 3
28 Study to Assess Safety and Efficacy of ELAD in Subjects With Severe Acute Alcoholic Hepatitis (sAAH) and Lille Score Failure Terminated NCT01829347 Phase 3
29 Registry Protocol for Tracking Trial Subjects After VTI-206 Study Completion Withdrawn NCT01452295 Phase 2, Phase 3 ELAD (Extracorporeal Liver Assist System)
30 Efficacy of Combination Therapy of Glucocorticoids and Bovine Colostrum in Treatment of Severe Alcoholic Hepatitis. Completed NCT02265328 Phase 2
31 A Safety and Efficacy Study of Mycophenolate Mofetil and Rilonacept in Patients With Alcoholic Hepatitis Completed NCT01903798 Phase 2 Rilonacept;Mycophenolate mofetil;Prednisolone
32 Efficacy and Safety of MG in the Patients With Alcoholic Fatty Liver Disease and Alcoholic Hepatitis Completed NCT02019056 Phase 2 Placebo /bid P.O;MG-1;MG-2 : MG1000mg, Placebo /bid P.O;metadoxine
33 Randomized, Controlled Trial of S-adenosylmethionine in Alcoholic Liver Disease Completed NCT00851981 Phase 2
34 Treating Nonalcoholic Steatohepatitis With Pioglitazone Completed NCT00062764 Phase 2 Actos (Pioglitazone)
35 Use of F-652 in Patients With Alcoholic Hepatitis Recruiting NCT02655510 Phase 1, Phase 2 F-652
36 Pegfilgrastim in Patients With Alcoholic Hepatitis Recruiting NCT02776059 Phase 2 Standard of care + pegfiltrastim;Standard of care
37 Trial of Obeticholic Acid in Patients With Moderately Severe Alcoholic Hepatitis (AH) Recruiting NCT02039219 Phase 2 Placebo;10 mg Obeticholic Acid (OCA)
38 Safety and Efficacy of IMM 124-E for Patients With Severe Alcoholic Hepatitis Recruiting NCT01968382 Phase 2 IMM 124-E (Hyperimmune Bovine Colostrum);Placebo (High protein milk powder)
39 Selonsertib in Combination With Prednisolone Versus Prednisolone Alone in Participants With Severe Alcoholic Hepatitis (AH) Active, not recruiting NCT02854631 Phase 2 Selonsertib;Prednisolone;Placebo
40 Effects of Rifaximin in Patients With Acute Alcoholic Hepatitis Enrolling by invitation NCT02116556 Phase 2 Prednisone;Rifaximin
41 A Research Study to Assess the Safety, Pharmacokinetics and Pharmacodynamics of DUR-928 in Patients With Alcoholic Hepatitis Not yet recruiting NCT03432260 Phase 2 DUR-928
42 Efficacy and Safety of Orally Administered DS102 in Patients With Acute Alcoholic Hepatitis Not yet recruiting NCT03452540 Phase 2 DS102
43 Study of IDN-6556 in Patients With Severe Alcoholic Hepatitis and Contraindications to Steroid Therapy Terminated NCT01912404 Phase 2 IDN-6556;Placebo
44 Pharmacokinetic and Pharmacodynamic Study of IDN-6556 in ACLF Terminated NCT01937130 Phase 2 IDN-6556
45 Treatment of Alcohol-Related Hepatitis With Arginine Withdrawn NCT00200746 Phase 2 Arginine
46 Fecal Microbial Transplant for Alcohol Misuse in Cirrhosis Recruiting NCT03416751 Phase 1
47 Pentoxifylline for Acute Alcoholic Hepatitis (AAH) Terminated NCT00205049 Phase 1 pentoxifylline
48 Pilot Study of Pentoxifylline for Hepatopulmonary Syndrome Terminated NCT00593658 Phase 1 pentoxifylline
49 Granulocyte Colony Stimulating Factor (G-CSF) in Acute Liver Failure and Alcoholic Hepatitis Unknown status NCT01341951 Granulocyte colony stimulating factor
50 Effects of Prednisolone and Pentoxifylline on the Regulation of Urea Synthesis in Alcoholic Hepatitis Completed NCT01245257

Search NIH Clinical Center for Alcoholic Hepatitis

Genetic Tests for Alcoholic Hepatitis

Anatomical Context for Alcoholic Hepatitis

MalaCards organs/tissues related to Alcoholic Hepatitis:

38
Liver, Brain, T Cells, Neutrophil, Monocytes, Adipocyte, Colon

Publications for Alcoholic Hepatitis

Articles related to Alcoholic Hepatitis:

(show top 50) (show all 667)
# Title Authors Year
1
Early liver transplantation for alcoholic hepatitis: Ready for primetime? ( 29175244 )
2018
2
Interaction between the patatin-like phospholipase domain-containing protein 3 genotype and coffee drinking and the risk for acute alcoholic hepatitis. ( 29404510 )
2018
3
Efficacy of Granulocyte Colony Stimulating Factor and N-acetyl Cysteine Therapies in Patients with Severe Alcoholic Hepatitis. ( 29391265 )
2018
4
Extracorporeal Cellular Therapy (ELAD) in Severe Alcoholic Hepatitis- A Multinational, Prospective, Controlled, Randomized Trial. ( 29385313 )
2018
5
Liver transplantation for alcoholic hepatitis: A systematic review with meta-analysis. ( 29324766 )
2018
6
Survival from alcoholic hepatitis has not improved over time. ( 29444123 )
2018
7
Ginsenoside Rg1 inhibits inflammatory responses via modulation of the nuclear factora89I_B pathway and inhibition of inflammasome activation in alcoholic hepatitis. ( 29207044 )
2018
8
Expression of proteins upregulated in hepatocellular carcinoma in patients with alcoholic hepatitis (AH) compared to non-alcoholic steatohepatitis (NASH): An immunohistochemical analysis of candidate proteins. ( 29425759 )
2018
9
People who survive an episode of severe alcoholic hepatitis should be advised to maintain total abstinence from alcohol. ( 29394458 )
2018
10
Liver Transplantation for Severe Alcoholic Hepatitis, Updated Lessons from the World's Largest Series. ( 29409981 )
2018
11
Alcoholic hepatitis versus non-alcoholic steatohepatitis: Levels of expression of some proteins involved in tumorigenesis. ( 29307797 )
2018
12
Modification Patterns of Urinary Albumin Correlates With Serum Albumin and Outcome in Severe Alcoholic Hepatitis. ( 29369844 )
2018
13
Early liver transplantation for severe alcoholic hepatitis: moving from controversy to consensus. ( 29389821 )
2018
14
Role of liver transplantation in severe alcoholic hepatitis. ( 29316778 )
2018
15
A new marker for severity of alcoholic hepatitis. ( 29427735 )
2018
16
Alcoholic Hepatitis: Continued drinking and the mourning after. ( 28671334 )
2017
17
Acute alcoholic hepatitis and liver transplantation: Waiting for Godot. ( 28845615 )
2017
18
Pre-therapy liver transcriptome landscape in Indian and French patients with severe alcoholic hepatitis and steroid responsiveness. ( 28754919 )
2017
19
Correction: Alcohol-related changes in the intestinal microbiome influence neutrophil infiltration, inflammation and steatosis in early alcoholic hepatitis in mice. ( 28562651 )
2017
20
The role of the IL-8 signaling pathway in the infiltration of granulocytes into the livers of patients with alcoholic hepatitis. ( 28818508 )
2017
21
Gutuo Jiejiu decoction improves survival of patients with severe alcoholic hepatitis: A retrospective cohort study. ( 28522913 )
2017
22
Treatment of severe alcoholic hepatitis: past, present and future. ( 28517024 )
2017
23
The role of Tec kinase signaling pathways in the development of Mallory Denk Bodies in balloon cells in alcoholic hepatitis. ( 28935395 )
2017
24
Alcoholic hepatitis: appropriate indication for liver transplantation? ( 28937405 )
2017
25
An exploratory genome-wide analysis of genetic risk for alcoholic hepatitis. ( 28776448 )
2017
26
Transjugular liver biopsy in severe alcoholic hepatitis. ( 28050823 )
2017
27
Medical Management of Severe Alcoholic Hepatitis: ExpertA Review from the Clinical Practice Updates Committee ofA the AGA Institute. ( 27979049 )
2017
28
Interobserver Variability in Scoring Liver Biopsies with a Diagnosis of Alcoholic Hepatitis. ( 28654190 )
2017
29
Circulating levels of bacterial DNA and risk of infections in severe alcoholic hepatitis. ( 28750768 )
2017
30
Prediction of histologic alcoholic hepatitis based on clinical presentation limits the need for liver biopsy. ( 29404443 )
2017
31
A prognostic evaluation and management of alcoholic hepatitis. ( 28602070 )
2017
32
Adult-onset Still's disease-like condition due to alcoholic hepatitis and vitamin B deficiency. ( 28691376 )
2017
33
Clinical Trial Design for Alcoholic Hepatitis. ( 29272895 )
2017
34
Plasma biomarkers to diagnose alcoholic hepatitis - are we there yet? ( 28941362 )
2017
35
Cell Death and Prognosis of Mortality in Alcoholic Hepatitis Patients Using Plasma Keratin-18. ( 28770701 )
2017
36
Review article: recent insights into clinical decision-making in severe alcoholic hepatitis. ( 28543549 )
2017
37
Severe Alcoholic Hepatitis: Atypical Presentation with Markedly Elevated Alkaline Phosphatase. ( 29226108 )
2017
38
Predicting short-term and long-term mortality of hospitalized Portuguese patients with alcoholic hepatitis. ( 28628497 )
2017
39
Hyperoxidized albumin modulates neutrophils to induce oxidative stress and inflammation in severe alcoholic hepatitis. ( 27775820 )
2017
40
Pyroptosis, a Novel Player for Alcoholic Hepatitis? ( 29222919 )
2017
41
Redefining successful treatment of severe alcoholic hepatitis. ( 28741287 )
2017
42
Application of prognostic scores in the STOPAH trial: Discriminant function is no longer the optimal scoring system in alcoholic hepatitis. ( 29175535 )
2017
43
Alcohol abstinence in patients surviving an episode of alcoholic hepatitis: Prediction and impact on long-term survival. ( 28646515 )
2017
44
Patients With Severe Alcoholic Hepatitis Given Prednisolone Therapy Who Have High Circulating Levels Of Bacterial DNA are at Increased Risk for Developing Infections. ( 28043903 )
2016
45
New treatment options for alcoholic hepatitis. ( 27099434 )
2016
46
Treatment of Severe Alcoholic Hepatitis. ( 26948886 )
2016
47
Correction: Spontaneous Evolution in Bilirubin Levels Predicts Liver-Related Mortality in Patients with Alcoholic Hepatitis. ( 27861575 )
2016
48
Alcoholic hepatitis: Translational approaches to develop targeted therapies. ( 26940353 )
2016
49
Case of severe alcoholic hepatitis treated with granulocytapheresis. ( 27900326 )
2016
50
Ammonia level at admission predicts in-hospital mortality for patients with alcoholic hepatitis. ( 27132633 )
2016

Variations for Alcoholic Hepatitis

Expression for Alcoholic Hepatitis

LifeMap Discovery
Genes differentially expressed in tissues of Alcoholic Hepatitis patients vs. healthy controls: 35 (show top 50) (show all 111)
# Gene Description Tissue Up/Dn Fold Change (log2) P value
1 AKR1B10 aldo-keto reductase family 1, member B10 (aldose reductase) Liver + 8.79 0.000
2 KRT23 keratin 23, type I Liver + 7.04 0.000
3 FOS FBJ murine osteosarcoma viral oncogene homolog Liver - 6.75 0.000
4 CCL20 chemokine (C-C motif) ligand 20 Liver + 6.56 0.000
5 KCNN2 potassium channel, calcium activated intermediate/small conductance subfamily N alpha, member 2 Liver - 6.11 0.000
6 SPINK1 serine peptidase inhibitor, Kazal type 1 Liver + 6.07 0.000
7 SPP1 secreted phosphoprotein 1 Liver + 6.04 0.000
8 LCN2 lipocalin 2 Liver + 5.74 0.000
9 CXCL6 chemokine (C-X-C motif) ligand 6 Liver + 5.55 0.000
10 COL1A2 collagen, type I, alpha 2 Liver + 5.33 0.000
11 FOSB FBJ murine osteosarcoma viral oncogene homolog B Liver - 5.08 0.000
12 LOXL4 lysyl oxidase-like 4 Liver + 5.01 0.000
13 PDZK1IP1 PDZK1 interacting protein 1 Liver + 4.95 0.000
14 CYP1A2 cytochrome P450, family 1, subfamily A, polypeptide 2 Liver - 4.91 0.000
15 GOLM1 golgi membrane protein 1 Liver + 4.87 0.000
16 NR4A2 nuclear receptor subfamily 4, group A, member 2 Liver - 4.85 0.000
17 MMP7 matrix metallopeptidase 7 Liver + 4.73 0.000
18 EFEMP1 EGF containing fibulin-like extracellular matrix protein 1 Liver + 4.63 0.000
19 CD24 CD24 molecule Liver + 4.57 0.000
20 GNMT glycine N-methyltransferase Liver - 4.50 0.000
21 PCOLCE2 procollagen C-endopeptidase enhancer 2 Liver - 4.48 0.000
22 CYP2C19 cytochrome P450, family 2, subfamily C, polypeptide 19 Liver - 4.45 0.000
23 TACSTD2 tumor-associated calcium signal transducer 2 Liver + 4.41 0.000
24 DCDC2 doublecortin domain containing 2 Liver + 4.28 0.000
25 EPCAM epithelial cell adhesion molecule Liver + 4.26 0.000
26 NQO1 NAD(P)H dehydrogenase, quinone 1 Liver + 4.10 0.000
27 MT1M metallothionein 1M Liver - 4.07 0.000
28 SOX9 SRY (sex determining region Y)-box 9 Liver + 3.99 0.000
29 THBS2 thrombospondin 2 Liver + 3.98 0.000
30 KRT7 keratin 7, type II Liver + 3.96 0.000
31 BICC1 BicC family RNA binding protein 1 Liver + 3.96 0.000
32 FABP4 fatty acid binding protein 4, adipocyte Liver + 3.94 0.000
33 IL32 interleukin 32 Liver + 3.94 0.000
34 PPP1R1A protein phosphatase 1, regulatory (inhibitor) subunit 1A Liver - 3.91 0.000
35 RRM2 ribonucleotide reductase M2 Liver + 3.90 0.000
36 CXCL8 chemokine (C-X-C motif) ligand 8 Liver + 3.90 0.000
37 VCAN versican Liver + 3.90 0.000
38 COL1A1 collagen, type I, alpha 1 Liver + 3.89 0.000
39 DUSP1 dual specificity phosphatase 1 Liver - 3.89 0.000
40 LGSN lengsin, lens protein with glutamine synthetase domain Liver - 3.78 0.000
41 COL5A1 collagen, type V, alpha 1 Liver + 3.77 0.000
42 SERPINE1 serpin peptidase inhibitor, clade E (nexin, plasminogen activator inhibitor type 1), member 1 Liver - 3.77 0.000
43 RGS4 regulator of G-protein signaling 4 Liver + 3.76 0.000
44 STMN2 stathmin 2 Liver + 3.72 0.000
45 SOX4 SRY (sex determining region Y)-box 4 Liver + 3.71 0.000
46 CLEC4M C-type lectin domain family 4, member M Liver - 3.69 0.000
47 ANXA2 annexin A2 Liver + 3.67 0.000
48 ANXA2P2 annexin A2 pseudogene 2 Liver + 3.66 0.000
49 CNDP1 carnosine dipeptidase 1 (metallopeptidase M20 family) Liver - 3.65 0.000
50 GPR88 G protein-coupled receptor 88 Liver - 3.64 0.000
Search GEO for disease gene expression data for Alcoholic Hepatitis.

Pathways for Alcoholic Hepatitis

Pathways related to Alcoholic Hepatitis according to GeneCards Suite gene sharing:

(show all 48)
# Super pathways Score Top Affiliating Genes
1
Show member pathways
13.5 CCL2 CXCL8 F2 ICAM1 IL10 IL22
2
Show member pathways
13.3 CCL2 CXCL8 ICAM1 IL10 IL22 IL6
3
Show member pathways
13.24 CCL2 CXCL8 IL10 IL22 IL6 TNF
4
Show member pathways
12.82 CXCL8 ICAM1 IL10 IL22 IL6 TNF
5
Show member pathways
12.77 CCL2 CXCL8 ICAM1 IL6 TNF
6
Show member pathways
12.58 CCL2 F2 IL10 IL6 TNF
7
Show member pathways
12.54 IL10 IL22 IL6 TNF
8
Show member pathways
12.51 CXCL8 ICAM1 IL6 TNF
9
Show member pathways
12.44 CCL2 CXCL8 IL10 IL6 LBP TNF
10
Show member pathways
12.31 CCL2 CXCL8 IL6 TNF
11
Show member pathways
12.25 CXCL8 IL6 LBP TNF
12 12.22 IL10 IL6 LBP TNF
13
Show member pathways
12.18 ALB CCL2 F2 ICAM1 IL6 TNF
14
Show member pathways
12.17 CXCL8 IL6 LBP TNF
15 12.16 CXCL8 IL10 IL6 TNF
16
Show member pathways
12.14 CXCL8 IL10 IL6 TNF
17 11.95 CCL2 ICAM1 IL6 TNF
18 11.94 IL10 IL6 TNF
19 11.93 CCL2 CXCL8 ICAM1 IL6 TNF
20
Show member pathways
11.89 IL10 IL6 TNF
21 11.87 CXCL8 IL10 IL6 TNF
22 11.85 CXCL8 ICAM1 LBP TNF
23
Show member pathways
11.84 CXCL8 ICAM1 IL6 LBP
24 11.8 CXCL8 IL6 LBP
25 11.8 CCL2 CXCL8 ICAM1 IL6 TNF
26 11.78 CXCL8 ICAM1 IL6
27 11.76 IL10 IL22 TNF
28 11.73 IL10 IL6 TNF
29 11.72 CXCL8 IL10 IL6 TNF
30 11.67 CCL2 CXCL8 ICAM1 IL6 TNF
31 11.64 ICAM1 IL10 IL6 TNF
32 11.61 CCL2 CXCL8 IL6 TNF
33
Show member pathways
11.6 CXCL8 ICAM1 IL6 TNF
34 11.59 CXCL8 IL6 TNF
35 11.52 ICAM1 IL6 TNF
36 11.36 IL10 IL6 TNF
37 11.35 CCL2 CXCL8 IL6
38 11.32 CCL2 CXCL8 ICAM1 IL10 IL6 TNF
39 11.31 IL22 IL6 TNF
40 11.28 IL10 IL6 TNF
41 11.28 ICAM1 IL10 IL6 TNF
42 11.22 CCL2 CXCL8 ICAM1 IL10 IL6 LBP
43 11.18 CCL2 F2 ICAM1
44 11.12 CCL2 CXCL8 ICAM1 IL10 IL6 TNF
45 11.01 CXCL8 IL6 TNF
46 11 CCL2 CXCL8 IL10 IL22 IL6 TNF
47 10.96 CCL2 CXCL8 IL10 IL22 IL6 TNF
48 10.93 CCL2 ICAM1 TNF

GO Terms for Alcoholic Hepatitis

Cellular components related to Alcoholic Hepatitis according to GeneCards Suite gene sharing:

# Name GO ID Score Top Affiliating Genes
1 extracellular region GO:0005576 9.65 ADAMTS13 ALB CCL2 CXCL8 F2 IL10
2 endoplasmic reticulum lumen GO:0005788 9.46 ADAMTS13 ALB F2 IL6
3 extracellular space GO:0005615 9.4 ADAMTS13 ALB CCL2 CXCL8 F2 GPT

Biological processes related to Alcoholic Hepatitis according to GeneCards Suite gene sharing:

(show all 28)
# Name GO ID Score Top Affiliating Genes
1 immune response GO:0006955 9.96 CCL2 CXCL8 IL10 IL6 TNF
2 platelet activation GO:0030168 9.81 ADAMTS13 F2 IL6
3 positive regulation of DNA binding transcription factor activity GO:0051091 9.8 IL10 IL6 TNF
4 inflammatory response GO:0006954 9.8 CCL2 CXCL8 IL10 IL22 IL6 TNF
5 defense response to Gram-positive bacterium GO:0050830 9.79 IL6 LBP TNF
6 cellular response to interferon-gamma GO:0071346 9.77 ADAMTS13 CCL2 ICAM1
7 cellular response to tumor necrosis factor GO:0071356 9.76 ADAMTS13 CCL2 CXCL8 ICAM1
8 cellular response to interleukin-1 GO:0071347 9.75 CCL2 CXCL8 ICAM1
9 humoral immune response GO:0006959 9.72 CCL2 IL6 TNF
10 positive regulation of interleukin-6 production GO:0032755 9.67 IL6 LBP TNF
11 embryonic digestive tract development GO:0048566 9.64 CXCL8 TNF
12 positive regulation of macrophage activation GO:0043032 9.63 IL10 LBP
13 response to molecule of bacterial origin GO:0002237 9.62 CXCL8 IL10
14 positive regulation of heterotypic cell-cell adhesion GO:0034116 9.61 IL10 TNF
15 lipopolysaccharide-mediated signaling pathway GO:0031663 9.61 CCL2 LBP TNF
16 PERK-mediated unfolded protein response GO:0036499 9.6 CCL2 CXCL8
17 negative regulation of lipid storage GO:0010888 9.58 IL6 TNF
18 positive regulation of chemokine production GO:0032722 9.58 IL6 LBP TNF
19 endothelial cell apoptotic process GO:0072577 9.57 IL10 TNF
20 response to glucocorticoid GO:0051384 9.56 IL10 IL22 IL6 TNF
21 positive regulation of leukocyte adhesion to vascular endothelial cell GO:1904996 9.54 ICAM1 TNF
22 negative regulation of growth of symbiont in host GO:0044130 9.54 IL10 LBP TNF
23 negative regulation of cytokine secretion involved in immune response GO:0002740 9.52 IL10 TNF
24 positive regulation of STAT protein import into nucleus GO:2000366 9.51 F2 IL6
25 regulation of receptor activity GO:0010469 9.5 CCL2 CXCL8 F2 IL10 IL22 IL6
26 receptor biosynthetic process GO:0032800 9.48 IL10 TNF
27 acute-phase response GO:0006953 9.46 F2 IL22 IL6 LBP
28 cellular response to lipopolysaccharide GO:0071222 9.23 ADAMTS13 CCL2 CXCL8 ICAM1 IL10 IL6

Molecular functions related to Alcoholic Hepatitis according to GeneCards Suite gene sharing:

# Name GO ID Score Top Affiliating Genes
1 cytokine activity GO:0005125 9.1 CCL2 CXCL8 IL10 IL22 IL6 TNF

Sources for Alcoholic Hepatitis

3 CDC
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