MCID: ALC006
MIFTS: 57

Alcoholic Hepatitis malady

Gastrointestinal diseases, Liver diseases categories

Summaries for Alcoholic Hepatitis

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63Wikipedia, 32MalaCards
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Wikipedia:63 Alcoholic hepatitis is hepatitis (inflammation of the liver) due to excessive intake of alcohol. It is... more...

MalaCards: Alcoholic Hepatitis, also known as acute alcoholic liver disease, is related to hepatitis and hepatitis a. An important gene associated with Alcoholic Hepatitis is F2 (coagulation factor II (thrombin)), and among its related pathways are Regulation by c-FLIP and ethanol degradation II. The compounds pentoxifylline and ulinastatin have been mentioned in the context of this disorder. Affiliated tissues include liver, brain and t cells, and related mouse phenotypes are liver/biliary system and hematopoietic system.

Aliases & Classifications for Alcoholic Hepatitis

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8Disease Ontology, 44Novoseek, 60UMLS, 56SNOMED-CT, 27ICD9CM, 39NCIt, 25ICD10
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Classifications:

Malacards categories (disease lists): (See all malacards categories)
Anatomical: Gastrointestinal diseases, Liver diseases


Aliases & Descriptions:

alcoholic hepatitis 8
acute alcoholic liver disease 8 60
acute alcoholic hepatitis 8 44
hepatitis, alcoholic 60
hepatitis alcoholic 44


External Ids:

Disease Ontology8 DOID:12351
ICD9CM27 571.1
SNOMED-CT56 9953008, 155810001
NCIt39 C34352
ICD1025 K70.1

Related Diseases for Alcoholic Hepatitis

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17GeneCards, 18GeneDecks
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Diseases related to Alcoholic Hepatitis via text searches within MalaCards or GeneCards/GeneDecks gene sharing:

(show top 50)    (show all 150)
idRelated DiseaseScoreTop Affiliating Genes
1hepatitis31.9HGF, F2, CYP2E1
2hepatitis a31.4F2
3liver cirrhosis30.7CYP2E1, F2, HGF, AKR1A1, LBP, ADAMTS13
4alcoholic liver cirrhosis30.6AKR1A1, IL8, CYP2E1, F2
5hepatitis c30.6CYP2E1, TNF, F2, IL10
6hepatitis b30.4FADD, F2
7viral hepatitis30.2AKR1A1, F2
8thrombocytopenia30.1F2, ADAMTS13
9hypertension30.1F2, ICAM1
10pneumonia30.1LBP, IL10, TNF, IL8, ICAM1
11fatty liver disease29.9CYP2E1
12acute pancreatitis29.9IL10, IL8, LBP
13pancreatitis29.9CYP2E1, ICAM1, IL10
14peritonitis29.9F2, TNF, LBP
15sarcoma29.9FADD
16alcoholic pancreatitis29.9AKR1A1, CYP2E1
17acute liver failure29.9F2, HGF
18graves' disease29.9ICAM1
19liver disease10.5
20hepatorenal syndrome10.3
21leukemoid reaction10.3
22hepatic encephalopathy10.2
23hepatitis e10.2
24portal hypertension10.1
25esophagitis10.1
26lung cancer10.0CYP2E1
27lupus erythematosus10.0F2
28oral cancer10.0CYP2E1
29purpura10.0ADAMTS13
30biliary atresia10.0HGF
31diabetic retinopathy10.0ICAM1
32hemolytic-uremic syndrome10.0ADAMTS13
33acute myocardial infarction10.0ADAMTS13
34molluscum contagiosum10.0IL18BP
35interstitial lung disease10.0TNF
36periodontitis10.0IL8
37obesity10.0CYP2E1, TNF
38atopy10.0IL10
39bronchiectasis10.0IL8
40cystic fibrosis10.0IL8, LBP
41periodontal disease10.0TNF, ICAM1
42crohn's disease10.0TNF
43myeloma10.0ICAM1, HGF
44alopecia areata10.0ICAM1
45bronchopulmonary dysplasia10.0IL8
46respiratory failure10.0ICAM1, TNF
47endometriosis10.0IL8, HGF
48arthropathy10.0TNF
49pulmonary fibrosis10.0IL8, HGF
50familial mediterranean fever10.0TNF

Graphical network of the top 20 diseases related to Alcoholic Hepatitis:



Diseases related to alcoholic hepatitis

Clinical Features for Alcoholic Hepatitis

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Drugs & Therapeutics for Alcoholic Hepatitis

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Sources:
5CenterWatch, 41NIH Clinical Center, 6ClinicalTrials, 60UMLS, 40NDF-RT
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Approved drugs:

Search CenterWatch for Alcoholic Hepatitis

Drug clinical trials:

Search ClinicalTrials for Alcoholic Hepatitis

Search NIH Clinical Center for Alcoholic Hepatitis

Search CenterWatch for Alcoholic Hepatitis

Genetic Tests for Alcoholic Hepatitis

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Anatomical Context for Alcoholic Hepatitis

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32MalaCards
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MalaCards organs/tissues related to Alcoholic Hepatitis:

32
Liver, Brain, T cells, Monocytes, Testes, Thyroid, Bone, Endothelial, Whole blood, Bone marrow, Kidney, Prostate

Animal Models for Alcoholic Hepatitis or affiliated genes

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Sources:
36MGI
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MGI Mouse Phenotypes related to Alcoholic Hepatitis:

36
idDescriptionMGI Source AccessionScoreTop Affiliating Genes
1MP:000537010.3TNF, FADD, LBP, CYP2E1, IL10, HGF
2MP:000539710.1TNFRSF14, F2, IL8, IL10, AKR1A1, FADD
3MP:000538710.0ADAMTS13, ICAM1, F2, IL8, IL10, AKR1A1
4MP:00053769.8S100A10, ICAM1, TNFRSF14, FADD, LBP, AKR1A1

Publications for Alcoholic Hepatitis

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50PubMed
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Articles related to Alcoholic Hepatitis:

(show top 50)    (show all 703)
idTitleAuthorsYear
1
A novel mortality model for acute alcoholic hepatitis including variables recorded after admission to hospital. (24377696)
2014
2
Treatment of severe alcoholic hepatitis with corticosteroids and pentoxifylline. (24026596)
2013
3
Pathogenesis of hepatic steatosis: the link between hypercortisolism and non-alcoholic fatty liver disease. (24187449)
2013
4
Management practices of hepatitis C virus infected alcoholic hepatitis patients: A survey of physicians. (23667769)
2013
5
Alcoholic hepatitis: diagnosis and management in 2012. (23237255)
2012
6
Granulocytapheresis and plasma exchange for severe alcoholic hepatitis. (22320926)
2012
7
Hepatic expression of CCL2 in alcoholic liver disease is associated with disease severity and neutrophil infiltrates. (22861370)
2012
8
Regulation of transglutaminase-mediated hepatic cell death in alcoholic steatohepatitis and non-alcoholic steatohepatitis. (22320917)
2012
9
Alcoholic hepatitis and liver transplantation:is an abstinence of six months necessary? (22510448)
2012
10
Lack of association between tumour necrosis factor receptor types 1 and 2 gene polymorphism and severe acute alcoholic hepatitis. (19641466)
2010
11
Clostridium septicum infection of hepatic metastases following alcohol injection: a case report. (20072687)
2009
12
Alcoholic hepatitis. (19553649)
2009
13
Treatment of severe forms of alcoholic hepatitis: where are we going? (18336666)
2008
14
Pentoxifylline: not just for alcoholic hepatitis anymore? (19669297)
2008
15
Human herpesvirus type 8 in patients with cirrhosis: correlation with sex, alcoholism, hepatitis B virus, disease severity, and thrombocytopenia. (18628092)
2008
16
Hematopoietic malignancies associated with viral and alcoholic hepatitis. (18957521)
2008
17
Gene expression patterns in hepatic tissue and visceral adipose tissue of patients with non-alcoholic fatty liver disease. (17953248)
2007
18
Evaluation of quantitative portal venous, hepatic arterial, and total hepatic tissue blood flow using xenon CT in alcoholic liver cirrhosis: comparison with liver cirrhosis C. (17331165)
2007
19
Genetic polymorphisms in antioxidant enzymes modulate hepatic iron accumulation and hepatocellular carcinoma development in patients with alcohol-induced cirrhosis. (16510607)
2006
20
Antioxidants versus corticosteroids in the treatment of severe alcoholic hepatitis--a randomised clinical trial. (16469404)
2006
21
Grading alcoholic hepatitis. (16025499)
2005
22
A randomized placebo controlled trial of vitamin E for alcoholic hepatitis. (14672612)
2004
23
Alcoholic Hepatitis. (15527711)
2004
24
Porphyria cutanea tarda, hepatitis C, alcoholism, and hemochromatosis: a case report and review of the literature. (15074347)
2004
25
Low-grade steatosis and major changes in portal flow as new prognostic factors in steroid-treated alcoholic hepatitis. (15565651)
2004
26
Abnormal hepatic methionine and glutathione metabolism in patients with alcoholic hepatitis. (14745316)
2004
27
Severe alcoholic hepatitis successfully treated by leukocytapheresis: a case report. (12960503)
2003
28
Duplex Doppler ultrasound of the hepatic artery in patients with acute alcoholic hepatitis. (11960073)
2002
29
Rhabdomyolysis, hepatitis and multiple hematological disorders associated with alcohol abuse: a case report. (12939102)
2002
30
Influence of superimposed alcoholic hepatitis on the outcome of liver transplantation for end-stage alcoholic liver disease. (12044530)
2002
31
Why can't Chinese Han drink alcohol? Hepatitis B virus infection and the evolution of acetaldehyde dehydrogenase deficiency. (12208210)
2002
32
Neutrophilic infiltration in alcoholic hepatitis. (12062632)
2002
33
Alcoholic hepatitis--glucocorticosteroids or not? (11943428)
2002
34
Steroidal management and serum cytokine profile of a case of alcoholic hepatitis with leukemoid reaction. (12374239)
2002
35
Rapidly progressive liver injury and fatal alcoholic hepatitis occurring after liver transplantation in alcoholic patients. (10401763)
1999
36
Abnormalities of peripheral blood T lymphocytes and natural killer cells in alcoholic hepatitis persist after a 3-month withdrawal period. (9194923)
1997
37
Polyenylphosphatidylcholine attenuates non-alcoholic hepatic fibrosis and accelerates its regression. (8773917)
1996
38
Corticosteroids and alcoholic hepatitis. (1824838)
1991
39
A randomized, controlled trial of treatment of alcoholic hepatitis with parenteral nutrition and oxandrolone. II. Short-term effects on nitrogen metabolism, metabolic balance, and nutrition. (1909086)
1991
40
Increased plasma tumor necrosis factor in severe alcoholic hepatitis. (2339855)
1990
41
Alcoholic hepatitis: pathogenesis and approaches to treatment. (2237274)
1990
42
Is protein-calorie malnutrition a problem in alcoholic hepatitis? (3923411)
1985
43
Acute viral hepatitis superimposed on alcoholic liver cirrhosis: clinical and histopathologic features. (3935897)
1985
44
Protein-calorie malnutrition associated with alcoholic hepatitis. Veterans Administration Cooperative Study Group on Alcoholic Hepatitis. (6421159)
1984
45
Short-term and long-term survival in patients with alcoholic hepatitis treated with oxandrolone and prednisolone. (6390194)
1984
46
Propylthiouracil treatment for alcoholic hepatitis: the case of the missing thirty. (7106528)
1982
47
A randomized clinical trial of insulin and glucagon infusion for treatment of alcoholic hepatitis: progress report in 50 patients. (7014349)
1981
48
Lymphocyte sequestration by the liver in alcoholic hepatitis. (311627)
1979
49
Hepatic collagen proline hydroxylase activity in alcoholic hepatitis: effect of d-penicillamine. (215682)
1979
50
Acute alcoholic hepatitis: diagnosis, treatment, prognosis. (4732643)
1973

Genetic Variations for Alcoholic Hepatitis

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Expression for genes affiliated with Alcoholic Hepatitis

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Sources:
1BioGPS, 15Gene Expression Omnibus DataSets
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Expression patterns in normal tissues for genes affiliated with Alcoholic Hepatitis

Search GEO for disease gene expression data for Alcoholic Hepatitis.

Pathways for genes affiliated with Alcoholic Hepatitis

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Sources:
53Reactome, 37NCBI BioSystems Database, 12EMD Millipore, 51QIAGEN, 29KEGG, 49PharmGKB
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Pathways related to Alcoholic Hepatitis according to GeneCards/GeneDecks:

(show all 20)
idSuper pathways (with members indented)ScoreTop Affiliating Genes
1
Hide members
10.4TNF, FADD
2
Hide members
10.4CYP2E1, ACSS2
310.4ICAM1, F2, TNF
410.4IL8, ICAM1, TNF
510.4IL8, IL10, TNF
610.4IL10, IL8, TNF
710.4ICAM1, TNF, IL10
8
Immune response Bacterial infections in normal airways
10.4TNF, IL8, LBP
9
Cytokine production by Th17 cells in CF (Mouse model)
10.4IL8, ICAM1, LBP
10
Hide members
10.3HGF, PIAS3, TNFRSF14
1110.3IL8, LBP, TNF, ICAM1
12
Hide members
10.3ICAM1, TNF, FADD, IL10
1310.3TNF, IL10, LBP, FADD
14
Hide members
10.3ALDH3A1, AKR1A1, ACSS2
15
Hide members
10.3TNF, TNFRSF14, FADD, LBP
16
Hide members
10.3TNF, ICAM1, TNFRSF14, FADD, IL8
17
Hide members
10.3LBP, IL8, IL10, FADD, TNF
18
Hide members
10.3CYP2E1, AKR1A1, ALDH3A1, ACSS2
19
Hide members
10.3TNF, HGF, IL8, F2, IL10, PIAS3
20
Hide members
10.3IL10, HGF, IL8, TNFRSF14, TNF, FADD

Compounds for genes affiliated with Alcoholic Hepatitis

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Sources:
44Novoseek, 11DrugBank, 28IUPHAR, 59Tocris Bioscience, 49PharmGKB, 24HMDB
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Compounds related to Alcoholic Hepatitis according to GeneCards/GeneDecks:

(show top 50)    (show all 110)
idCompoundScoreTop Affiliating Genes
1pentoxifylline44 1111.9CYP2E1
2ulinastatin4410.9ICAM1
3cycloheximide4410.8HGF
4diphenyleneiodonium4410.8DUOX1, CYP2E1
5cdp5714410.8ICAM1, TNF, IL10
6gm-csf44 2811.8TNF, ICAM1, IL10
7interferon gamma4410.8IL10, ICAM1, TNF
8endotoxin4410.8ADAMTS13, LBP, ICAM1, IL18BP
9groalpha4410.8TNF, IL8, IL10, ICAM1
10lipoteichoic acid4410.7TNF, LBP, IL8, IL10
118-isoprostane4410.7ICAM1, TNF, IL10, IL8
12polymyxin b4410.7IL10, LBP, TNF, ICAM1, IL8
13sp 60012544 5911.7HGF, IL8, FADD, ICAM1, TNF
14n-tosyl-l-phenylalanine chloromethyl ketone4410.7TNF, ICAM1, IL8
15il 104410.7LBP, TNF, IL10, IL8
16tarc4410.7TNF, ICAM1, IL10, IL8
17pdtc4410.7IL8
18cyclophosphamide44 49 1112.7HGF, CYP2E1, ALDH3A1, ADAMTS13
19gabexate mesilate4410.7IL10, IL8, TNF
20simvastatin44 49 59 28 11 2415.7F2, IL8, IL10, TNF, ICAM1
21peptidoglycan44 2811.7IL10, LBP, TNF, IL8
22toxin-14410.7TNF, IL10, IL8
23h2o24410.7HGF, ICAM1, DUOX1, CYP2E1
24sb 20358044 5911.7IL10, ICAM1, IL8, HGF, TNF, CYP2E1
25ccl344 2811.7IL10, ICAM1, TNF, IL8
26azithromycin44 1111.7IL10, F2, IL8
27cyclosporin a44 28 5912.7HGF, TNF, IL8, IL10, ADAMTS13, ICAM1
28n acetylcysteine4410.7HGF, ICAM1, AKR1A1, IL8, TNF, F2
29acetaldehyde44 28 2412.7CYP2E1, ALDH3A1, HGF, AKR1A1, ACSS2, IL10
30lactate4410.7HGF, ICAM1, TNF, AKR1A1, CYP2E1, F2
31mip 1alpha4410.7IL8, IL10, TNF
32dexamethasone44 49 28 1113.6LBP, HGF, CYP2E1
33neopterin4410.6ICAM1, TNF, IL10, IL8
34histamine44 28 2412.6ICAM1, TNF, AKR1A1, HGF, IL10, IL8
35acetic acid44 28 11 2413.6ALDH3A1, ACSS2, AKR1A1, HGF
36natalizumab44 1111.6ICAM1, IL10, TNF
37creatinine4410.6CYP2E1, IL18BP, LBP, HGF, AKR1A1, ADAMTS13
38ethanol44 49 11 2413.6FADD, AKR1A1, ALDH3A1, ACSS2, CYP2E1, HGF
39actinomycin d4410.6IL8, LBP, FADD, TNF, HGF, ICAM1
40aprotinin44 1111.6IL8
41oxygen44 2411.5HGF, DUOX1, IL8, ALDH3A1, AKR1A1, LBP
42thalidomide44 49 59 1113.5CYP2E1, HGF, TNF, IL10
43superoxide44 2411.5DUOX1, AKR1A1, TNF, LBP
444-hydroxynonenal44 2411.5ALDH3A1, CYP2E1, IL10, AKR1A1
45nash4410.5TNF, AKR1A1, CYP2E1
465 aminosalicylic acid4410.4IL10, IL8, TNF
47il-124410.4TNF, IL8, IL10
48imiquimod44 28 59 1113.4IL10, IL8, TNF
49staurosporin4410.1ICAM1, TNF, IL8
50lipid4410.0ACSS2, AKR1A1, HGF, ALDH3A1, TNF, CYP2E1

GO Terms for genes affiliated with Alcoholic Hepatitis

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16Gene Ontology
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Cellular components related to Alcoholic Hepatitis according to GeneCards/GeneDecks:

idNameGO IDScoreTop Affiliating Genes
1extracellular spaceGO:00561510.1ADAMTS13, F2, IL18BP, IL8, IL10, LBP

Biological processes related to Alcoholic Hepatitis according to GeneCards/GeneDecks:

(show all 11)
idNameGO IDScoreTop Affiliating Genes
1negative regulation of growth of symbiont in hostGO:04413010.6IL10, LBP, TNF
2cellular response to lipopolysaccharideGO:07122210.6IL8, IL10, LBP, ICAM1
3receptor biosynthetic processGO:03280010.6TNF, IL10
4defense response to Gram-positive bacteriumGO:05083010.5TNFRSF14, TNF, LBP
5response to drugGO:04249310.5ICAM1, TNF, CYP2E1, IL10, ALDH3A1
6cellular response to tumor necrosis factorGO:07135610.5IL18BP, IL8, ICAM1
7necrotic cell deathGO:07026510.5TNF, FADD
8negative regulation of cytokine secretion involved in immune responseGO:00274010.4IL10
9cellular aldehyde metabolic processGO:00608110.4ALDH3A1, AKR1A1
10response to glucocorticoid stimulusGO:05138410.3ALDH3A1, IL10, TNF
11response to molecule of bacterial originGO:00223710.1IL8, IL10

Products for genes affiliated with Alcoholic Hepatitis

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  • Antibodies
  • Proteins
  • Lysates
  • Antibodies

Sources for Alcoholic Hepatitis

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3CDC
13ExPASy
14FMA
22GTR
23HGMD
24HMDB
25ICD10
26ICD10 via Orphanet
27ICD9CM
28IUPHAR
29KEGG
34MeSH
35MESH via Orphanet
36MGI
39NCIt
40NDF-RT
43NINDS
44Novoseek
46OMIM
47OMIM via Orphanet
50PubMed
51QIAGEN
57SNOMED-CT via Orphanet
60UMLS
61UMLS via Orphanet