MCID: ALC006
MIFTS: 59

Alcoholic Hepatitis malady

Categories: Gastrointestinal diseases, Liver diseases

Aliases & Classifications for Alcoholic Hepatitis

Aliases & Descriptions for Alcoholic Hepatitis:

Name: Alcoholic Hepatitis 38 12 14
Acute Alcoholic Liver Disease 12 69
Acute Alcoholic Hepatitis 12 52
Hepatitis, Alcoholic 69
Hepatitis Alcoholic 52

Classifications:



External Ids:

Disease Ontology 12 DOID:12351
ICD9CM 35 571.1
NCIt 47 C34352
SNOMED-CT 64 155810001 9953008
ICD10 33 K70.1
UMLS 69 C0001306

Summaries for Alcoholic Hepatitis

MalaCards based summary : Alcoholic Hepatitis, also known as acute alcoholic liver disease, is related to hepatitis and fatty liver disease. An important gene associated with Alcoholic Hepatitis is F2 (Coagulation Factor II, Thrombin), and among its related pathways/superpathways are TGF-Beta Pathway and Cytokine Signaling in Immune system. The drugs Caspofungin and Miconazole have been mentioned in the context of this disorder. Affiliated tissues include liver, brain and t cells, and related phenotypes are homeostasis/metabolism and immune system

Wikipedia : 71 Alcoholic hepatitis is hepatitis (inflammation of the liver) due to excessive intake of alcohol. It is... more...

Related Diseases for Alcoholic Hepatitis

Diseases related to Alcoholic Hepatitis via text searches within MalaCards or GeneCards Suite gene sharing:

(show top 50) (show all 323)
id Related Disease Score Top Affiliating Genes
1 hepatitis 31.3 IL10 IL6 TNF
2 fatty liver disease 10.8
3 vps11-related autosomal recessive hypomyelinating leukodystrophy 10.3 IL6 TNF
4 congenital dyserythropoietic anemia 10.3 ALB TNF
5 nondystrophic myotonia 10.3 ALB F2
6 acute infection of pinna 10.3 CRP F2
7 oculomotor nerve paralysis 10.3 CXCL8 IL6
8 thymic neuroendocrine carcinoma 10.3 CXCL8 IL6 TNF
9 esophagus lymphoma 10.2 CXCL8 IL6 TNF
10 hepatitis a 10.2
11 common peroneal nerve lesion 10.2 CXCL8 IL6
12 coloboma of iris 10.2 CRP IL6
13 acquired thrombocytopenia 10.2 CXCL8 IL6 TNF
14 orthostatic proteinuria 10.2 CXCL8 IL6 TNF
15 dyslexia 5 10.2 IL6 TNF
16 chromophobe adenoma 10.2 CXCL8 ICAM1
17 migraine with aura 10.2 IL6 SLC17A5 TNF
18 leydig cell hypoplasia 10.2 IL6 SLC17A5 TNF
19 unilateral multicystic dysplastic kidney 10.2 CRP IL6 TNF
20 swine influenza 10.2 CRP IL6 TNF
21 nasopharyngitis 10.2 CXCL8 IL6 TNF
22 human immunodeficiency virus infectious disease 10.2 CRP IL6 TNF
23 stenosis of lacrimal sac 10.2 CXCL8 IL6 TNF
24 joint disorders 10.2 CRP IL6 TNF
25 splenic marginal zone lymphoma 10.2 CXCL8 IL6 TNF
26 benign neonatal seizures 10.2 CRP IL6 TNF
27 conjunctival concretion 10.2 CXCL8 IL6 TNF
28 aortic atherosclerosis 10.2 IL6 TNF
29 laryngotracheoesophageal cleft type 2 10.2 CRP IL6 SLC17A5
30 mikulicz disease 10.2 ALB IL6 TNF
31 spondylolysis 10.2 CXCL8 IL6 TNF
32 childhood type dermatomyositis 10.2 F2 IL6 TNF
33 cataract 10.2 ALB CRP TNF
34 degenerative disc disease 10.2 IL6 TNF
35 pancreas lymphoma 10.2 CRP IL6 TNF
36 carotenemia 10.2 CRP IL6 TNF
37 labyrinthine bilateral reactive loss 10.2 ALB CXCL8 IL6
38 capillary leak syndrome 10.2 ALB CRP CXCL8
39 hypertropia 10.2 ALB CRP TNF
40 pyoderma gangrenosum 10.2 CXCL8 IL6 TNF
41 chondroma 10.2 CRP IL6 TNF
42 urticaria 10.2 ALB CRP TNF
43 tracheitis 10.2 CXCL8 ICAM1 TNF
44 granulomatous hepatitis 10.2 CRP F2 IL6
45 gastric neuroendocrine tumor type 1 10.2 GPT SLC17A5
46 shoulder impingement syndrome 10.2 ALB CRP IL6
47 familial renal papillary carcinoma 10.2 ALB CXCL8 TNF
48 obstructive jaundice 10.2 ALB F2 TNF
49 avoidant personality disorder 10.2 CXCL8 IL6 TNF
50 ulcerative proctitis 10.2 CCL2 CXCL8 TNF

Comorbidity relations with Alcoholic Hepatitis via Phenotypic Disease Network (PDN): (show all 12)


Active Peptic Ulcer Disease Acute Cystitis
Acute Pancreatitis Alcohol Abuse
Alcoholic Gastritis Alcoholic Liver Cirrhosis
Alcoholic Neuropathy Deficiency Anemia
Fatty Liver Disease Hepatic Encephalopathy
Portal Hypertension Protein-Energy Malnutrition

Graphical network of the top 20 diseases related to Alcoholic Hepatitis:



Diseases related to Alcoholic Hepatitis

Symptoms & Phenotypes for Alcoholic Hepatitis

MGI Mouse Phenotypes related to Alcoholic Hepatitis:

44
id Description MGI Source Accession Score Top Affiliating Genes
1 homeostasis/metabolism MP:0005376 10 ADAMTS13 ALB CRP CYP2E1 F2 ICAM1
2 immune system MP:0005387 9.81 TNF ADAMTS13 CCL2 CRP F2 ICAM1
3 liver/biliary system MP:0005370 9.43 ALB CYP2E1 IL10 IL6 LBP TNF
4 neoplasm MP:0002006 9.1 ALB CYP2E1 ICAM1 IL10 IL6 TNF

Drugs & Therapeutics for Alcoholic Hepatitis

Drugs for Alcoholic Hepatitis (from DrugBank, HMDB, Dgidb, PharmGKB, IUPHAR, NovoSeek, BitterDB):

(show top 50) (show all 169)
id Name Status Phase Clinical Trials Cas Number PubChem Id
1
Caspofungin Approved Phase 4 179463-17-3, 162808-62-0 468682 2826718
2
Miconazole Approved, Investigational, Vet_approved Phase 4,Phase 3 22916-47-8 4189
3
Acamprosate Approved, Investigational Phase 4 77337-76-9 71158
4
Ethanol Approved Phase 4,Phase 3,Phase 2,Phase 1 64-17-5 702
5
Pentoxifylline Approved, Investigational Phase 4,Phase 3,Phase 2,Phase 1 6493-05-6 4740
6
Lenograstim Approved Phase 4,Phase 3,Phase 2 135968-09-1
7
Prednisone Approved, Vet_approved Phase 4,Phase 2 53-03-2 5865
8
Octreotide Approved, Investigational Phase 4 83150-76-9 383414 6400441
9
Somatostatin Approved Phase 4 38916-34-6, 51110-01-1 53481605
10
Acetylcysteine Approved, Investigational Phase 4,Phase 3 616-91-1 12035
11
Metformin Approved Phase 4 657-24-9 14219 4091
12
Ledipasvir Approved Phase 4 1256388-51-8 67505836
13
Sofosbuvir Approved Phase 4 1190307-88-0 45375808
14
Alprostadil Approved, Investigational Phase 4 745-65-3 149351
15
Entecavir Approved, Investigational Phase 4 142217-69-4 153941
16
Choline Approved, Nutraceutical Phase 4 62-49-7 305
17
Folic Acid Approved, Nutraceutical, Vet_approved Phase 4,Phase 2 59-30-3 6037
18
Pyridoxal Approved, Nutraceutical Phase 4,Phase 2 66-72-8 1050
19
Pyridoxine Approved, Nutraceutical, Vet_approved Phase 4,Phase 2 65-23-6 1054
20
Vitamin C Approved, Nutraceutical Phase 4 50-81-7 5785 54670067
21 Antimetabolites Phase 4,Phase 1
22 Gastrointestinal Agents Phase 4,Phase 3,Phase 2,Phase 1,Early Phase 1
23 Hypolipidemic Agents Phase 4
24 Lipid Regulating Agents Phase 4
25 Nootropic Agents Phase 4
26 Polyene phosphatidylcholine Phase 4
27 Liver Extracts Phase 4,Phase 3,Phase 2,Phase 1,Early Phase 1
28 Antifungal Agents Phase 4,Phase 3
29 Anti-Infective Agents Phase 4,Phase 3,Phase 2,Phase 1,Early Phase 1
30 Echinocandins Phase 4
31 Anti-Inflammatory Agents Phase 4,Phase 3,Phase 2,Early Phase 1
32 Antineoplastic Agents, Hormonal Phase 4,Phase 3,Phase 2,Early Phase 1
33 Antioxidants Phase 4,Phase 3,Phase 2,Phase 1
34 glucocorticoids Phase 4,Phase 3,Phase 2,Early Phase 1
35 Hormone Antagonists Phase 4,Phase 3,Phase 2,Early Phase 1
36 Hormones Phase 4,Phase 3,Phase 2,Early Phase 1
37 Hormones, Hormone Substitutes, and Hormone Antagonists Phase 4,Phase 3,Phase 2,Early Phase 1
38 Phosphodiesterase Inhibitors Phase 4,Phase 3,Phase 2,Phase 1
39 Platelet Aggregation Inhibitors Phase 4,Phase 3,Phase 2,Phase 1
40 Protective Agents Phase 4,Phase 3,Phase 2,Phase 1,Early Phase 1
41 Radiation-Protective Agents Phase 4,Phase 3,Phase 2,Phase 1
42 Vasodilator Agents Phase 4,Phase 3,Phase 2,Phase 1
43 Adjuvants, Immunologic Phase 4,Phase 3,Phase 2
44 Anti-Bacterial Agents Phase 4,Phase 3,Phase 2,Early Phase 1
45 Antiviral Agents Phase 4,Phase 3,Phase 1
46 Metadoxine Phase 4,Phase 2
47 Micronutrients Phase 4,Phase 2,Phase 3
48 Trace Elements Phase 4,Phase 2,Phase 3
49 Vitamin B 6 Phase 4,Phase 2
50 Vitamin B Complex Phase 4,Phase 2

Interventional clinical trials:

(show top 50) (show all 111)
id Name Status NCT ID Phase
1 Efficacy and Safety of S-adenosyl-l-methionine in Treatment of Alcoholic Hepatitis With Cholestasis Unknown status NCT02024295 Phase 4
2 Effect of Probiotics on Gut-Liver Axis of Alcoholic Hepatitis Unknown status NCT02335632 Phase 4
3 Pharmacokinetics of Caspofungin After One Dose in Patients With Liver Failure Unknown status NCT01968395 Phase 4
4 Safety of Acamprosate for Alcohol Dependence in the Elderly: An Open-Label Study (SAFADIE) Unknown status NCT00655967 Phase 4
5 Metadoxine as a Therapy for Severe Alcoholic Hepatitis Completed NCT02161653 Phase 4
6 The Effect of High Dose Vitamin C on the Liver Function in Chronic Hepatitis Patients Completed NCT01413360 Phase 4
7 Effect of Probiotics on Gut-Liver Axis of Alcoholic Liver Disease Completed NCT01501162 Phase 4
8 Somatostatin, Octreotide, Pentoxyfilline in the Prevention of Post-ERCP Pancreatitis and Molecular Markers Completed NCT00222092 Phase 4
9 G-CSF Plus NAC In Severe Alcoholic Hepatitis Recruiting NCT02971306 Phase 4
10 Effect of Metadoxine on Oxidative Stress in Non-alcoholic Hepatic Steatosis Recruiting NCT02051842 Phase 4
11 Determine the Efficacy and Safety of Harvoni in Genotype 1 Chronic Hepatitis c Infected People Who Are Alcoholics Recruiting NCT02759861 Phase 4
12 RCT Study on Granulocyte Colony-stimulating Factor(G-CSF) Treatment of Hepatic Failure Recruiting NCT02331745 Phase 4
13 Rifaximin Use in Severe Alcoholic Hepatitis Unknown status NCT02485106 Phase 3
14 Short-term Survival in Patients With Severe Alcoholic Hepatitis Treated With Steroid Versus Pentoxifylline Unknown status NCT01455337 Phase 3
15 Probiotics for Portal Hypertension Unknown status NCT01134692 Phase 3
16 Tenofovir Versus Lamivudine for Patients of Chronic Hepatitis B With Severe Acute Exacerbation Unknown status NCT01848743 Phase 3
17 N-Acetylcysteine in Severe Acute Alcoholic Hepatitis Completed NCT00962442 Phase 3
18 Treatment of Severe Alcoholic Hepatitis With Corticoids Plus N Acetyl Cysteine Versus Corticoids Alone Completed NCT00863785 Phase 3
19 Double-blind Randomized Controlled Trial in Severe Alcoholic Hepatitis Completed NCT01214226 Phase 3
20 Assess Safety and Efficacy of ELAD (Extracorporeal Liver Assist System) in Subjects With Alcohol-Induced Liver Failure Completed NCT01471028 Phase 3
21 Trial for Hepatocellular Carcinoma Adjuvant Treatment by Lipiocis Completed NCT00116454 Phase 3
22 Efficacy and Safety of the Extracorporeal Liver Assist Device (ELAD) in Acute on Chronic Hepatitis Completed NCT00973817 Phase 2, Phase 3
23 Efficacy of Granulocyte Colony-stimulating Factor and Erythropoetin for Patients With Acute-on-chronic Liver Failure Completed NCT01383460 Phase 3
24 A Placebo-Controlled, Double-Blind Study to Confirm the Reversal of Hepatorenal Syndrome Type 1 With Terlipressin Completed NCT01143246 Phase 3
25 Efficacy and Safety of G-CSF in Patients With Severe Alcoholic Hepatitis With Null or Partial Response to Steroid Recruiting NCT02442180 Phase 3
26 Efficacy Study of Anakinra, Pentoxifylline, and Zinc Compared to Methylprednisolone in Severe Acute Alcoholic Hepatitis Recruiting NCT01809132 Phase 2, Phase 3
27 Efficacy of Antibiotic Therapy in Severe Alcoholic Hepatitis Treated With Prednisolone Recruiting NCT02281929 Phase 3
28 N-ACetylcysteine to Reduce Infection and Mortality for Alcoholic Hepatitis Recruiting NCT03069300 Phase 3
29 Randomized, Open-Label, Multicenter, Controlled, Pivotal Study to Assess Safety and Efficacy of ELAD in Subjects w/ AILD Recruiting NCT02612428 Phase 3
30 Granulocyte Colony Stimulating Factor And Growth Hormone In Cirrhosis Of Liver: An Open Label Study Recruiting NCT02451033 Phase 2, Phase 3
31 REnal Function in Liver Transplantation: Everolimus With Calcineurin Inhibitor (CNI)-Sparing sTrategy Recruiting NCT02115113 Phase 3
32 To Study the Effect of Nonselective Beta Blockers in Advanced Stage Liver Disease With Ascites Recruiting NCT02649335 Phase 3
33 Comparison of Bovine Colostrum Versus Placebo in Treatment of Severe Alcoholic Hepatitis: A Randomized Double Blind Controlled Trial Not yet recruiting NCT02473341 Phase 3
34 Study to Assess Safety and Efficacy of ELAD in Subjects With Severe Acute Alcoholic Hepatitis (sAAH) and Lille Score Failure Terminated NCT01829347 Phase 3
35 Registry Protocol for Tracking Trial Subjects After VTI-206 Study Completion Withdrawn NCT01452295 Phase 2, Phase 3
36 Efficacy of Combination Therapy of Glucocorticoids and Bovine Colostrum in Treatment of Severe Alcoholic Hepatitis. Completed NCT02265328 Phase 2
37 A Safety and Efficacy Study of Mycophenolate Mofetil and Rilonacept in Patients With Alcoholic Hepatitis Completed NCT01903798 Phase 2
38 Efficacy and Safety of MG in the Patients With Alcoholic Fatty Liver Disease and Alcoholic Hepatitis Completed NCT02019056 Phase 2
39 Randomized, Controlled Trial of S-adenosylmethionine in Alcoholic Liver Disease Completed NCT00851981 Phase 2
40 Treating Nonalcoholic Steatohepatitis With Pioglitazone Completed NCT00062764 Phase 2
41 Effect of Candesartan in Alcoholic Liver Fibrosis Completed NCT00990639 Phase 1, Phase 2
42 A Phase II, Double-blinded, Randomized, Controlled Study to Evaluate the Efficacy and Safety of Vitalliver in Patients With Decompensated Cirrhosis Completed NCT00562783 Phase 2
43 Safety and Efficacy of IMM 124-E for Patients With Severe Alcoholic Hepatitis Recruiting NCT01968382 Phase 2
44 Use of F-652 in Patients With Alcoholic Hepatitis Recruiting NCT02655510 Phase 1, Phase 2
45 Trial of Obeticholic Acid in Patients With Moderately Severe Alcoholic Hepatitis (AH) Recruiting NCT02039219 Phase 2
46 Selonsertib in Combination With Prednisolone Versus Prednisolone Alone in Participants With Severe Alcoholic Hepatitis (AH) Recruiting NCT02854631 Phase 2
47 Effects of Rifaximin in Patients With Acute Alcoholic Hepatitis Enrolling by invitation NCT02116556 Phase 2
48 Pegfilgrastim in Patients With Alcoholic Hepatitis Not yet recruiting NCT02776059 Phase 2
49 Study of IDN-6556 in Patients With Severe Alcoholic Hepatitis and Contraindications to Steroid Therapy Terminated NCT01912404 Phase 2
50 Pharmacokinetic and Pharmacodynamic Study of IDN-6556 in ACLF Terminated NCT01937130 Phase 2

Search NIH Clinical Center for Alcoholic Hepatitis

Genetic Tests for Alcoholic Hepatitis

Anatomical Context for Alcoholic Hepatitis

MalaCards organs/tissues related to Alcoholic Hepatitis:

39
Liver, Brain, T Cells, Neutrophil, Monocytes, Colon, Adipocyte

Publications for Alcoholic Hepatitis

Articles related to Alcoholic Hepatitis:

(show top 50) (show all 627)
id Title Authors Year
1
Transjugular liver biopsy in severe alcoholic hepatitis. ( 28050823 )
2017
2
Medical Management of Severe Alcoholic Hepatitis: ExpertA Review from the Clinical Practice Updates Committee ofA the AGA Institute. ( 27979049 )
2017
3
Hyperoxidized albumin modulates neutrophils to induce oxidative stress and inflammation in severe alcoholic hepatitis. ( 27775820 )
2017
4
Correction: Spontaneous Evolution in Bilirubin Levels Predicts Liver-Related Mortality in Patients with Alcoholic Hepatitis. ( 27861575 )
2016
5
MELD score & serum sodium levels in predicting prognosis in patients of acute alcoholic hepatitis. ( 27728335 )
2016
6
New treatment options for alcoholic hepatitis. ( 27099434 )
2016
7
Effects of Age, Sex, Body Weight, and Quantity of Alcohol Consumption on Occurrence and Severity of Alcoholic Hepatitis. ( 27320325 )
2016
8
Alcoholic hepatitis: Translational approaches to develop targeted therapies. ( 26940353 )
2016
9
Treatment of Severe Alcoholic Hepatitis. ( 26948886 )
2016
10
The impact of race and ethnicity on mortality and healthcare utilization in alcoholic hepatitis: a cross-sectional study. ( 27724882 )
2016
11
Intensive Enteral Nutrition in Alcoholic Hepatitis: More Food for Thought. ( 26924095 )
2016
12
Pharmacologic Treatment of Alcoholic Hepatitis: Examining Outcomes Based on Disease Severity Stratification. ( 28003716 )
2016
13
Alcoholic hepatitis: should we combine old drugs for better results? ( 27638331 )
2016
14
Pitfalls of Treating Alcoholic Hepatitis: Recognizing Hemolytic Anemia in Zieve's Syndrome. ( 27125716 )
2016
15
Healthy Donor Fecal Microbiota Transplantation in Steroid Ineligible Severe Alcoholic Hepatitis - A Pilot Study. ( 27816755 )
2016
16
Patients With Severe Alcoholic Hepatitis Given Prednisolone Therapy Who Have High Circulating Levels Of Bacterial DNA are at Increased Risk for Developing Infections. ( 28043903 )
2016
17
Ammonia level at admission predicts in-hospital mortality for patients with alcoholic hepatitis. ( 27132633 )
2016
18
Sequential therapy consisting of glucocorticoid infusions followed by granulocyte-monocyte absorptive apheresis in patients with severe alcoholic hepatitis. ( 27858246 )
2016
19
Liver volume is a prognostic indicator for clinical outcome of patients with alcoholic hepatitis. ( 27604894 )
2016
20
Practical Concerns and Controversies in the Management of Alcoholic Hepatitis. ( 27917083 )
2016
21
What are the mechanisms of regeneration inhibition in alcoholic hepatitis? ( 27189521 )
2016
22
Treatment of alcoholic hepatitis: is this a "dead-end"? ( 27065743 )
2016
23
Alcoholic Hepatitis Markedly Decreases the Capacity for Urea Synthesis. ( 27379798 )
2016
24
Corticosteroids Versus Pentoxifylline for Severe Alcoholic Hepatitis: A Sequential Analysis of Randomized Controlled Trials. ( 27404293 )
2016
25
A Day-4 Lille Model Predicts Response to Corticosteroids and Mortality in Severe Alcoholic Hepatitis. ( 27922027 )
2016
26
Is pentoxifylline effective in alcoholic hepatitis? A9First update. ( 25353639 )
2016
27
Alcoholic Hepatitis: Pathogenesis, Diagnosis and Treatment. ( 27457347 )
2016
28
Mallory Denk Body Formation in Alcoholic Hepatitis: The Pivotal Role of Interleukin-8 Signaling. ( 27019857 )
2016
29
New therapeutic targets in alcoholic hepatitis. ( 27072540 )
2016
30
Bovine colostrum plus corticosteroids in treatment of severe alcoholic hepatitis: A prospective, proof of concept trial. ( 27727715 )
2016
31
Prednisolone plus S-adenosil-L-methionine in severe alcoholic hepatitis. ( 27337960 )
2016
32
Metabolomics studies identify novel diagnostic and prognostic indicators in patients with alcoholic hepatitis. ( 27057307 )
2016
33
Standard Definitions and Common Data Elements for Clinical Trials in Patients With Alcoholic Hepatitis: Recommendation From the NIAAA Alcoholic Hepatitis Consortia. ( 26921783 )
2016
34
Effect of SIRS and sepsis on mortality in alcoholic hepatitis: A systematic review and meta-analysis. ( 27782895 )
2016
35
Three-year Results of a Pilot Program in Early Liver Transplantation for Severe Alcoholic Hepatitis. ( 27280501 )
2016
36
Upregulation of autophagy components in alcoholic hepatitis and nonalcoholic steatohepatitis. ( 27432584 )
2016
37
Diagnosis and Treatment of Alcoholic Hepatitis: A Systematic Review. ( 27254289 )
2016
38
Alcoholic hepatitis histological score has high accuracy to predict 90-day mortality and response to steroids. ( 27026082 )
2016
39
Adacolumn Granulocyte-Apheresis for Alcoholic Hepatitis: Preliminary Study. ( 27109954 )
2016
40
Liver Transplantation for Alcoholic Hepatitis. ( 27611611 )
2016
41
Prognosis and Prognostic Scoring Models for Alcoholic Liver Disease and Acute Alcoholic Hepatitis. ( 27373611 )
2016
42
Acute Alcoholic Hepatitis: Therapy. ( 27373613 )
2016
43
LPS-TLR4 Pathway Mediates Ductular Cell Expansion in Alcoholic Hepatitis. ( 27752144 )
2016
44
Malondialdehyde as a Prognostic Factor in Alcoholic Hepatitis. ( 28007738 )
2016
45
Assessing endotoxemia in alcoholic hepatitis. ( 27123567 )
2016
46
Acute Alcoholic Hepatitis, the Clinical Aspects. ( 27373612 )
2016
47
Assessment of scoring systems for acute-on-chronic liver failure at predicting short-term mortality in patients with alcoholic hepatitis. ( 27895407 )
2016
48
The Worsening Profile of Alcoholic Hepatitis in the United States. ( 27147285 )
2016
49
The damage-associated molecular pattern HMGB1 is elevated in human alcoholic hepatitis, but does not seem to be a primary driver of inflammation. ( 27357188 )
2016
50
Current Management of Alcoholic Hepatitis and Future Therapies. ( 27350941 )
2016

Variations for Alcoholic Hepatitis

Expression for Alcoholic Hepatitis

LifeMap Discovery
Genes differentially expressed in tissues of Alcoholic Hepatitis patients vs. healthy controls: 35 (show top 50) (show all 111)
id Gene Description Tissue Up/Dn Fold Change (log2) P value
1 AKR1B10 aldo-keto reductase family 1, member B10 (aldose reductase) Liver + 8.79 0.000
2 KRT23 keratin 23, type I Liver + 7.04 0.000
3 FOS FBJ murine osteosarcoma viral oncogene homolog Liver - 6.75 0.000
4 CCL20 chemokine (C-C motif) ligand 20 Liver + 6.56 0.000
5 KCNN2 potassium channel, calcium activated intermediate/small conductance subfamily N alpha, member 2 Liver - 6.11 0.000
6 SPINK1 serine peptidase inhibitor, Kazal type 1 Liver + 6.07 0.000
7 SPP1 secreted phosphoprotein 1 Liver + 6.04 0.000
8 LCN2 lipocalin 2 Liver + 5.74 0.000
9 CXCL6 chemokine (C-X-C motif) ligand 6 Liver + 5.55 0.000
10 COL1A2 collagen, type I, alpha 2 Liver + 5.33 0.000
11 FOSB FBJ murine osteosarcoma viral oncogene homolog B Liver - 5.08 0.000
12 LOXL4 lysyl oxidase-like 4 Liver + 5.01 0.000
13 PDZK1IP1 PDZK1 interacting protein 1 Liver + 4.95 0.000
14 CYP1A2 cytochrome P450, family 1, subfamily A, polypeptide 2 Liver - 4.91 0.000
15 GOLM1 golgi membrane protein 1 Liver + 4.87 0.000
16 NR4A2 nuclear receptor subfamily 4, group A, member 2 Liver - 4.85 0.000
17 MMP7 matrix metallopeptidase 7 Liver + 4.73 0.000
18 EFEMP1 EGF containing fibulin-like extracellular matrix protein 1 Liver + 4.63 0.000
19 CD24 CD24 molecule Liver + 4.57 0.000
20 GNMT glycine N-methyltransferase Liver - 4.50 0.000
21 PCOLCE2 procollagen C-endopeptidase enhancer 2 Liver - 4.48 0.000
22 CYP2C19 cytochrome P450, family 2, subfamily C, polypeptide 19 Liver - 4.45 0.000
23 TACSTD2 tumor-associated calcium signal transducer 2 Liver + 4.41 0.000
24 DCDC2 doublecortin domain containing 2 Liver + 4.28 0.000
25 EPCAM epithelial cell adhesion molecule Liver + 4.26 0.000
26 NQO1 NAD(P)H dehydrogenase, quinone 1 Liver + 4.10 0.000
27 MT1M metallothionein 1M Liver - 4.07 0.000
28 SOX9 SRY (sex determining region Y)-box 9 Liver + 3.99 0.000
29 THBS2 thrombospondin 2 Liver + 3.98 0.000
30 KRT7 keratin 7, type II Liver + 3.96 0.000
31 BICC1 BicC family RNA binding protein 1 Liver + 3.96 0.000
32 FABP4 fatty acid binding protein 4, adipocyte Liver + 3.94 0.000
33 IL32 interleukin 32 Liver + 3.94 0.000
34 PPP1R1A protein phosphatase 1, regulatory (inhibitor) subunit 1A Liver - 3.91 0.000
35 RRM2 ribonucleotide reductase M2 Liver + 3.90 0.000
36 CXCL8 chemokine (C-X-C motif) ligand 8 Liver + 3.90 0.000
37 VCAN versican Liver + 3.90 0.000
38 COL1A1 collagen, type I, alpha 1 Liver + 3.89 0.000
39 DUSP1 dual specificity phosphatase 1 Liver - 3.89 0.000
40 LGSN lengsin, lens protein with glutamine synthetase domain Liver - 3.78 0.000
41 COL5A1 collagen, type V, alpha 1 Liver + 3.77 0.000
42 SERPINE1 serpin peptidase inhibitor, clade E (nexin, plasminogen activator inhibitor type 1), member 1 Liver - 3.77 0.000
43 RGS4 regulator of G-protein signaling 4 Liver + 3.76 0.000
44 STMN2 stathmin 2 Liver + 3.72 0.000
45 SOX4 SRY (sex determining region Y)-box 4 Liver + 3.71 0.000
46 CLEC4M C-type lectin domain family 4, member M Liver - 3.69 0.000
47 ANXA2 annexin A2 Liver + 3.67 0.000
48 ANXA2P2 annexin A2 pseudogene 2 Liver + 3.66 0.000
49 CNDP1 carnosine dipeptidase 1 (metallopeptidase M20 family) Liver - 3.65 0.000
50 GPR88 G protein-coupled receptor 88 Liver - 3.64 0.000
Search GEO for disease gene expression data for Alcoholic Hepatitis.

Pathways for Alcoholic Hepatitis

Pathways related to Alcoholic Hepatitis according to GeneCards Suite gene sharing:

(show all 43)
id Super pathways Score Top Affiliating Genes
1
Show member pathways
13.47 CCL2 CXCL8 F2 ICAM1 IL10 IL6
2
Show member pathways
13.31 CCL2 CXCL8 ICAM1 IL10 IL6 LBP
3
Show member pathways
12.85 CCL2 CXCL8 IL10 IL6 LBP TNF
4
Show member pathways
12.81 CXCL8 ICAM1 IL10 IL6 TNF
5
Show member pathways
12.76 CCL2 CXCL8 ICAM1 IL6 TNF
6
Show member pathways
12.55 CCL2 F2 IL10 IL6 TNF
7
Show member pathways
12.3 CCL2 CXCL8 IL6 TNF
8
Show member pathways
12.24 CXCL8 IL6 LBP TNF
9 12.2 IL10 IL6 LBP TNF
10
Show member pathways
12.16 CXCL8 IL6 LBP TNF
11 12.15 CXCL8 IL10 IL6 TNF
12
Show member pathways
12.13 ALB CCL2 CRP F2 ICAM1 IL6
13
Show member pathways
12.12 CXCL8 IL10 IL6 TNF
14 11.93 IL10 IL6 TNF
15 11.93 CCL2 CXCL8 ICAM1 IL6 TNF
16 11.92 CCL2 ICAM1 IL6 TNF
17
Show member pathways
11.89 IL10 IL6 TNF
18 11.86 CXCL8 IL10 IL6 TNF
19 11.85 CXCL8 ICAM1 LBP TNF
20
Show member pathways
11.83 CXCL8 ICAM1 IL6 LBP
21 11.8 CCL2 CXCL8 ICAM1 IL6 TNF
22
Show member pathways
11.79 CRP IL6 LBP
23 11.79 CXCL8 IL6 LBP
24 11.77 CXCL8 ICAM1 IL6
25 11.73 IL10 IL6 TNF
26 11.72 CXCL8 IL10 IL6 TNF
27 11.72 CCL2 CXCL8 ICAM1 IL6 TNF
28 11.67 ICAM1 IL10 IL6 TNF
29 11.6 CCL2 CXCL8 IL6 TNF
30
Show member pathways
11.58 CXCL8 ICAM1 IL6 TNF
31 11.57 CXCL8 IL6 TNF
32 11.5 ICAM1 IL6 TNF
33 11.35 IL10 IL6 TNF
34 11.32 CCL2 CXCL8 IL6
35 11.32 CCL2 CXCL8 ICAM1 IL10 IL6 TNF
36 11.28 ICAM1 IL10 IL6 TNF
37 11.26 IL10 IL6 TNF
38 11.22 CCL2 CXCL8 ICAM1 IL10 IL6 LBP
39 11.17 CCL2 F2 ICAM1
40 11.14 CCL2 CXCL8 IL10 IL6 TNF
41 11.12 CCL2 CXCL8 ICAM1 IL10 IL6 TNF
42 10.93 CCL2 ICAM1 TNF
43 10.9 CRP CXCL8 IL6 TNF

GO Terms for Alcoholic Hepatitis

Cellular components related to Alcoholic Hepatitis according to GeneCards Suite gene sharing:

id Name GO ID Score Top Affiliating Genes
1 extracellular region GO:0005576 9.65 ADAMTS13 ALB CCL2 CRP CXCL8 F2
2 endoplasmic reticulum lumen GO:0005788 9.56 ADAMTS13 ALB F2 IL6
3 external side of plasma membrane GO:0009897 9.46 F2 ICAM1 IL6 TNF
4 extracellular space GO:0005615 9.4 ADAMTS13 ALB CCL2 CRP CXCL8 F2

Biological processes related to Alcoholic Hepatitis according to GeneCards Suite gene sharing:

(show all 44)
id Name GO ID Score Top Affiliating Genes
1 positive regulation of ERK1 and ERK2 cascade GO:0070374 9.91 CCL2 ICAM1 IL6 TNF
2 response to drug GO:0042493 9.91 CCL2 CYP2E1 ICAM1 IL10 IL6
3 response to ethanol GO:0045471 9.86 CCL2 CYP2E1 ICAM1
4 platelet activation GO:0030168 9.86 ADAMTS13 F2 IL6
5 positive regulation of sequence-specific DNA binding transcription factor activity GO:0051091 9.85 IL10 IL6 TNF
6 regulation of cell shape GO:0008360 9.85 CCL2 F2 ICAM1 IL6
7 response to wounding GO:0009611 9.83 CCL2 F2 IL6
8 response to insulin GO:0032868 9.82 ICAM1 IL10 IL6
9 cellular response to interferon-gamma GO:0071346 9.81 ADAMTS13 CCL2 ICAM1
10 inflammatory response GO:0006954 9.8 CCL2 CRP CXCL8 IL10 IL6 TNF
11 humoral immune response GO:0006959 9.79 CCL2 IL6 TNF
12 positive regulation of interleukin-6 production GO:0032755 9.77 IL6 LBP TNF
13 positive regulation of nitric oxide biosynthetic process GO:0045429 9.77 ICAM1 IL6 TNF
14 response to lipopolysaccharide GO:0032496 9.77 CCL2 ICAM1 IL10 IL6 LBP
15 cellular response to estradiol stimulus GO:0071392 9.76 CCL2 IL10 IL6
16 cellular response to interleukin-1 GO:0071347 9.76 CCL2 CXCL8 ICAM1 IL6
17 response to amino acid GO:0043200 9.73 CCL2 ICAM1 IL6
18 response to glucocorticoid GO:0051384 9.73 CCL2 IL10 IL6 TNF
19 cellular response to dexamethasone stimulus GO:0071549 9.71 CCL2 ICAM1 IL6
20 defense response to Gram-positive bacterium GO:0050830 9.71 CRP IL6 LBP TNF
21 lipopolysaccharide-mediated signaling pathway GO:0031663 9.7 CCL2 LBP TNF
22 embryonic digestive tract development GO:0048566 9.69 CXCL8 TNF
23 positive regulation of vascular smooth muscle cell proliferation GO:1904707 9.69 IL10 TNF
24 cellular response to hepatocyte growth factor stimulus GO:0035729 9.68 IL10 IL6
25 response to molecule of bacterial origin GO:0002237 9.68 CXCL8 IL10
26 positive regulation of macrophage activation GO:0043032 9.67 IL10 LBP
27 positive regulation of heterotypic cell-cell adhesion GO:0034116 9.67 IL10 TNF
28 PERK-mediated unfolded protein response GO:0036499 9.67 CCL2 CXCL8
29 positive regulation of chemokine production GO:0032722 9.67 IL6 LBP TNF
30 cellular response to nutrient levels GO:0031669 9.66 ICAM1 IL6
31 opsonization GO:0008228 9.66 CRP LBP
32 endothelial cell apoptotic process GO:0072577 9.65 IL10 TNF
33 negative regulation of growth of symbiont in host GO:0044130 9.65 IL10 LBP TNF
34 positive regulation of cellular extravasation GO:0002693 9.64 CCL2 ICAM1
35 negative regulation of cytokine secretion involved in immune response GO:0002740 9.63 IL10 TNF
36 epithelial cell proliferation involved in salivary gland morphogenesis GO:0060664 9.62 IL6 TNF
37 regulation of vascular endothelial growth factor production GO:0010574 9.61 CCL2 IL6
38 receptor biosynthetic process GO:0032800 9.58 IL10 TNF
39 positive regulation of leukocyte adhesion to vascular endothelial cell GO:1904996 9.57 ICAM1 TNF
40 cellular response to tumor necrosis factor GO:0071356 9.55 ADAMTS13 CCL2 CXCL8 ICAM1 IL6
41 negative regulation of lipid storage GO:0010888 9.43 CRP IL6 TNF
42 acute-phase response GO:0006953 9.26 CRP F2 IL6 LBP
43 cellular response to lipopolysaccharide GO:0071222 9.23 ADAMTS13 CCL2 CXCL8 ICAM1 IL10 IL6
44 immune response GO:0006955 10.04 CCL2 CXCL8 IL10 IL6 TNF

Molecular functions related to Alcoholic Hepatitis according to GeneCards Suite gene sharing:

id Name GO ID Score Top Affiliating Genes
1 cytokine activity GO:0005125 9.02 CCL2 CXCL8 IL10 IL6 TNF

Sources for Alcoholic Hepatitis

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