MCID: ALC009
MIFTS: 51

Alcoholic Liver Cirrhosis malady

Gastrointestinal diseases, Liver diseases categories

Summaries for Alcoholic Liver Cirrhosis

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34MalaCards
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MalaCards: Alcoholic Liver Cirrhosis, also known as portal cirrhosis, is related to liver cirrhosis and hepatitis. An important gene associated with Alcoholic Liver Cirrhosis is ADH4 (alcohol dehydrogenase 4 (class II), pi polypeptide), and among its related pathways are Vitamin A and carotenoid metabolism and Abacavir Pathway, Pharmacokinetics/Pharmacodynamics. The compounds p-nitroanisole and nitrosamine have been mentioned in the context of this disorder. Affiliated tissues include liver, bone and bone marrow.

Aliases & Classifications for Alcoholic Liver Cirrhosis

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Sources:
9Disease Ontology, 11DISEASES, 46Novoseek, 63UMLS, 59SNOMED-CT, 41NCIt, 36MeSH, 28ICD9CM, 26ICD10
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Classifications:

Malacards categories (disease lists): (See all malacards categories)
Anatomical: Gastrointestinal diseases, Liver diseases


Aliases & Descriptions:

alcoholic liver cirrhosis 9 11
portal cirrhosis 9 46 63
alcoholic cirrhosis 9 46
laennec's cirrhosis, alcoholic 9
portal cirrhosis unspecified 9
alcoholic cirrhosis of liver 9
liver cirrhosis, alcoholic 63
laennec's cirrhosis 9


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Disease Ontology9 DOID:14018
NCIt41 C34782
MeSH36 D008104
ICD9CM28 571.2
ICD1026 K70.3

Related Diseases for Alcoholic Liver Cirrhosis

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Sources:
18GeneCards, 19GeneDecks
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Graphical network of the top 20 diseases related to Alcoholic Liver Cirrhosis:



Diseases related to alcoholic liver cirrhosis

Symptoms for Alcoholic Liver Cirrhosis

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Drugs & Therapeutics for Alcoholic Liver Cirrhosis

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Sources:
6CenterWatch, 43NIH Clinical Center, 7ClinicalTrials, 63UMLS, 42NDF-RT
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Approved drugs:

Search CenterWatch for Alcoholic Liver Cirrhosis

Drug clinical trials:

Search ClinicalTrials for Alcoholic Liver Cirrhosis

Search NIH Clinical Center for Alcoholic Liver Cirrhosis

Search CenterWatch for Alcoholic Liver Cirrhosis

Genetic Tests for Alcoholic Liver Cirrhosis

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Anatomical Context for Alcoholic Liver Cirrhosis

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Sources:
32LifeMap Discoveryā„¢, 34MalaCards
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MalaCards organs/tissues related to Alcoholic Liver Cirrhosis:

34
Liver, Bone, Bone marrow, Small intestine, Monocytes, T cells, Thyroid, Skin, B cells

LifeMap Discovery
The database of embryonic development, stem cell research and regenerative medicine

Cells/anatomical compartments in embryo or adult related to Alcoholic Liver Cirrhosis:
id TissueAnatomical CompartmentCell Relevance
1 LiverLiver LobuleHepatocytes Affected by disease

Animal Models for Alcoholic Liver Cirrhosis or affiliated genes

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Publications for Alcoholic Liver Cirrhosis

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53PubMed
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Articles related to Alcoholic Liver Cirrhosis:

(show top 50)    (show all 201)
idTitleAuthorsYear
1
Serum amyloid A and C-reactive protein positive nodule in alcoholic liver cirrhosis, hard to make definite diagnosis. (23607539)
2013
2
Different patterns of decompensation in patients with alcoholic vs. non-alcoholic liver cirrhosis. (22530565)
2012
3
Iliopsoas muscle hematoma secondary to alcoholic liver cirrhosis. (23185153)
2012
4
Induction of blood lymphocyte cytochrome P450 2E1 in early stage alcoholic liver cirrhosis. (20843640)
2011
5
Potential therapeutic application of intravenous autologous bone marrow infusion in patients with alcoholic liver cirrhosis. (21417817)
2011
6
Systemic and hepatic vein galectin-3 are increased in patients with alcoholic liver cirrhosis and negatively correlate with liver function. (21715185)
2011
7
Endotoxin and tumor necrosis factor-receptor levels in portal and hepatic vein of patients with alcoholic liver cirrhosis receiving elective transjugular intrahepatic portosystemic shunt. (21971377)
2011
8
Pathogenesis and management of alcoholic liver cirrhosis: a review. (24367215)
2011
9
Clinical course of alcoholic liver cirrhosis: a Danish population-based cohort study. (20186844)
2010
10
Alcohol abstinence and orthotopic liver transplantation in alcoholic liver cirrhosis. (19460531)
2009
11
Do common genetic variants in endotoxin signaling pathway contribute to predisposition to alcoholic liver cirrhosis? (19278365)
2009
12
A functional polymorphism of the NFKB1 gene increases the risk for alcoholic liver cirrhosis in patients with alcohol dependence. (19673747)
2009
13
Polymorphism in glutathione-S-transferases: a risk factor in alcoholic liver cirrhosis. (19157724)
2009
14
Alcohol dehydrogenase and aldehyde dehydrogenase gene polymorphism in alcohol liver cirrhosis and alcohol chronic pancreatitis among Polish individuals. (17454860)
2007
15
Evaluation of quantitative portal venous, hepatic arterial, and total hepatic tissue blood flow using xenon CT in alcoholic liver cirrhosis: comparison with liver cirrhosis C. (17331165)
2007
16
Clinical challenges and images in GI. Image 2. Perforative peritonitis on sclerosing encapsulating peritonitis (abdominal cocoon) in a patient with alcoholic liver cirrhosis. (17383416)
2007
17
Auxiliary partial orthotopic living donor liver transplantation in a patient with alcoholic liver cirrhosis to overcome donor steatosis. (16623878)
2006
18
Osteoprotegerin and RANKL in alcoholic liver cirrhosis. (15780054)
2005
19
Unique hypervascular nodules in alcoholic liver cirrhosis: identical to focal nodular hyperplasia-like nodules? (15582133)
2004
20
Erythropoietin increases platelet reactivity and platelet counts in patients with alcoholic liver cirrhosis: a randomized, double-blind, placebo-controlled study. (15298638)
2004
21
Spontaneous regurgitation of portal blood flow normalized by meal intake in a patient with alcoholic liver cirrhosis. (12644050)
2003
22
Polymorphisms in the DNA repair gene XRCC1 and susceptibility to alcoholic liver cirrhosis in older Southeastern Brazilians. (12175549)
2002
23
Indication of liver transplantation in severe alcoholic liver cirrhosis: quantitative evaluation and optimal timing. (11804670)
2002
24
Impaired accommodation of proximal stomach in patients with alcoholic liver cirrhosis. (12523589)
2002
25
Mechanisms of endotoxin tolerance in patients with alcoholic liver cirrhosis: role of interleukin 10, interleukin 1 receptor antagonist, and soluble tumour necrosis factor receptors as well as effector cell desensitisation. (10896923)
2000
26
N-acetyltransferase-2, glutathione S-transferase M1, alcohol dehydrogenase, and cytochrome P450IIE1 genotypes in alcoholic liver cirrhosis: a case-control study. (10232877)
1999
27
Influence of liver failure, ascites, and energy expenditure on the response to oral nutrition in alcoholic liver cirrhosis. (9263252)
1997
28
Serum and ascitic levels of soluble intercellular adhesion molecule-1 in patients with alcoholic liver cirrhosis: relation to biochemical markers of disease activity and alcohol intake. (8865970)
1996
29
Survival in alcoholic liver cirrhosis: prognostic value of portal pressure, size of esophageal varices and biochemical data. Comparison with Child classification. (8776835)
1996
30
Aeromonas sobria infection with severe muscle degeneration in a patient with alcoholic liver cirrhosis. (8540527)
1995
31
Impaired secretion and mRNA expression of monokines by alveolar macrophages from nonsmoking patients with alcoholic liver cirrhosis. (7876633)
1995
32
Thallium-201 per rectal scintigraphy improves prognostic evaluation in alcoholic liver cirrhosis of low and mid severity. (7661170)
1995
33
Association of a restriction fragment length polymorphism in the alcohol dehydrogenase 2 gene with Japanese alcoholic liver cirrhosis. (8583138)
1995
34
Spontaneous bacterial peritonitis and culture negative neutrocytic ascites in patients with non-alcoholic liver cirrhosis. (7827291)
1994
35
Reduced concentration of hepatic alpha-tocopherol in patients with alcoholic liver cirrhosis. (1580927)
1992
36
The concentration of thiamin and thiamin phosphate esters in patients with alcoholic liver cirrhosis. (1476555)
1992
37
Mechanism of feminization in male patients with non-alcoholic liver cirrhosis: role of sex hormone-binding globulin. (1916151)
1991
38
Insulin-like growth factor I: a good indicator of functional hepatocellular capacity in alcoholic liver cirrhosis. (1865082)
1991
39
L-alanine plasma levels after oral loads in non-alcoholic liver cirrhosis: relationship with urea extraformation and ammoniogenesis. (1742521)
1991
40
Increased levels of fibrinolysis reaction products (D-dimer) in patients with decompensated alcoholic liver cirrhosis. (1754853)
1991
41
Morphologic changes of small intestine epithelium in the course of post-alcoholic liver cirrhosis. (2347293)
1990
42
Studies on the monocyte interleukin-1 and tumour necrosis factor-alpha production in patients with alcoholic liver cirrhosis. (2636361)
1989
43
High interleukin-6 serum levels and increased production by leucocytes in alcoholic liver cirrhosis. Correlation with IgA serum levels and lymphokines production. (2505958)
1989
44
Bone changes in alcoholic liver cirrhosis. A histomorphometrical analysis of 52 cases. (3044713)
1988
45
Impaired early insulin response to intravenous glucose in alcoholic liver cirrhosis. (3296134)
1987
46
Pneumococcal vaccination: the response of patients with alcoholic liver cirrhosis. (6479858)
1984
47
Cholecystokinin-stimulated and postprandial serum concentrations of bile acids in alcoholic liver cirrhosis. (6474087)
1984
48
T-cell subsets in peripheral blood and ascitic fluid of patients with alcoholic liver cirrhosis. (6136678)
1983
49
Reticuloendothelial function in patients with alcoholic liver cirrhosis. (7323686)
1981
50
Autoantibodies, histocompatibility antigens and testosterone in males with alcoholic liver cirrhosis. (6973433)
1981

Variations for Alcoholic Liver Cirrhosis

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Expression for genes affiliated with Alcoholic Liver Cirrhosis

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Sources:
2BioGPS, 16Gene Expression Omnibus DataSets
See all sources
Expression patterns in normal tissues for genes affiliated with Alcoholic Liver Cirrhosis

Search GEO for disease gene expression data for Alcoholic Liver Cirrhosis.

Pathways for genes affiliated with Alcoholic Liver Cirrhosis

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Sources:
51PathCards, 39NCBI BioSystems Database, 56Reactome, 52PharmGKB, 61Thomson Reuters, 31KEGG
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Pathways related to Alcoholic Liver Cirrhosis according to GeneCards/GeneDecks:

(show all 21)
idSuper pathways (with members indented)ScoreTop Affiliating Genes
1
Show member pathways
9.7CYP2E1, ADH4
29.6ADH1C, ADH1B
39.5CYP2E1, CYP2A6
49.5CYP2A6, CYP2E1
59.5CYP2E1, CYP2A6
6
Show member pathways
9.4CYP2E1, ALDH2
7
Show member pathways
bupropion degradation39
methylglyoxal degradation III39
nicotine degradation III39
nicotine degradation IV39
9.1CYP2A6, ADH1B, CYP2E1
8
Show member pathways
acetate conversion to acetyl-CoA39
oxidative ethanol degradation III39
ethanol degradation IV39
9.0ALDH2, ADH1B, CYP2E1
9
Show member pathways
Retinol metabolism61
8.9CYP2A6, CYP2E1, ALDH2
10
Show member pathways
tryptophan degradation X (mammalian, via tryptamine)39
2-amino-3-carboxymuconate semialdehyde degradation to glutaryl-CoA39
tryptophan degradation39
glutaryl-CoA degradation39
serotonin degradation39
NAD de novo biosynthesis39
superpathway of melatonin degradation39
tryptophan degradation to 2-amino-3-carboxymuconate semialdehyde39
tryptophan utilization I39
melatonin degradation I39
8.9CYP2A6, ADH1B, ALDH2
118.7CYP2A6, NAT2, CYP2E1
12
Show member pathways
8.7NAT2, CYP2A6, CYP2E1
13
Show member pathways
8.7ADH4, ADH1B, ADH1C, ALDH2
14
Show member pathways
phenylalanine utilization39
noradrenaline and adrenaline degradation39
phenylalanine degradation IV39
8.7ADH4, ALDH2, ADH1B, ADH1C
15
Show member pathways
glycolysis39
gluconeogenesis39
Glycolysis and Gluconeogenesis39
8.7ADH1B, ALDH2, ADH1C, ADH4
16
Show member pathways
mitochondrial L-carnitine shuttle pathway39
Saturated fatty acid biosynthesis61
8.7ADH1C, ADH4, ADH1B, ALDH2
17
Show member pathways
8.5NAT2, ALDH2, CYP2A6
18
Show member pathways
7.7ADH4, ALDH2, ADH1B, CYP2A6, CYP2E1, ADH1C
19
Show member pathways
7.5ADH1C, CYP2A6, ADH4, ADH1B, CYP2E1, NAT2
20
Show member pathways
6.9CYP2A6, ADH1B, ADH4, ADH1C, NAT2, CYP2E1
21
Show member pathways
6.9ADH1C, CYP2A6, ALDH2, ADH1B, ADH4, CYP2E1

Compounds for genes affiliated with Alcoholic Liver Cirrhosis

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Sources:
46Novoseek, 12DrugBank, 25HMDB, 52PharmGKB, 62Tocris Bioscience, 30IUPHAR, 3BitterDB
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Compounds related to Alcoholic Liver Cirrhosis according to GeneCards/GeneDecks:

(show top 50)    (show all 173)
idCompoundScoreTop Affiliating Genes
1p-nitroanisole469.9CYP2A6, CYP2E1
2nitrosamine469.9CYP2E1, CYP2A6
3ndpa469.9CYP2A6, CYP2E1
4n-nitrosomethylbenzylamine469.9CYP2E1, CYP2A6
5diallylsulfide469.9CYP2E1, CYP2A6
61,3-dimethyluric acid469.9CYP2E1, CYP2A6
73-methylxanthine469.8CYP2A6, CYP2E1
84-methylpyrazole469.7CYP2A6, CYP2E1
91-aminobenzotriazole469.7CYP2A6, CYP2E1
10chloralhydrate469.6CYP2E1, ALDH2
11pyrazole46 1210.6ADH1C, CYP2E1, CYP2A6
12nitrosamines469.5CYP2E1, CYP2A6
13tienilic acid469.5CYP2E1, CYP2A6
14Aniline25 1210.5CYP2E1, NAT2
15betaine aldehyde46 2510.5ADH1B, ADH1C, ALDH2
163a,7a-Dihydroxy-5b-cholestan-26-al259.5ADH1C, ADH1B, ALDH2
171,7-dimethyluric acid46 2510.4NAT2, CYP2A6
181-methyluric acid46 2510.4NAT2, CYP2A6
193,4-Dihydroxyphenylglycol259.3ADH1C, ADH1B
20afmu469.3NAT2, CYP2A6
21disulfiram46 52 62 1212.3CYP2A6, ALDH2, CYP2E1
22mspi469.2CYP2E1, ADH1B, NAT2
231-methylxanthine46 2510.2CYP2A6, CYP2E1, NAT2
24dimethylnitrosamine469.2NAT2, CYP2E1, CYP2A6
25mephenytoin46 52 1211.2NAT2, CYP2E1, CYP2A6
26debrisoquine46 5210.1CYP2E1, NAT2, CYP2A6
27paraoxon46 2510.1NAT2, CYP2A6, CYP2E1
28isoniazid46 52 1211.1CYP2E1, CYP2A6, NAT2
29chlorzoxazone46 30 1211.1NAT2, CYP2E1, CYP2A6
30paraxanthine46 2510.1NAT2, CYP2E1, CYP2A6
31rifampin52 1210.1CYP2A6, NAT2, CYP2E1
32tolbutamide46 30 52 1212.1CYP2E1, CYP2A6, NAT2
33midazolam46 52 1211.1CYP2E1, CYP2A6, NAT2
34epoxide469.1CYP2A6, NAT2, CYP2E1
35nad30 2510.0ALDH2, ADH1C, ADH1B, ADH4
36rifampicin46 30 6211.0CYP2A6, CYP2E1, NAT2
37gsts469.0NAT2, CYP2E1, ALDH2
38nadh46 25 1211.0ADH1B, ALDH2, ADH1C, ADH4
39formaldehyde46 2510.0CYP2E1, ALDH2, ADH1C, CYP2A6
40betacarotene468.9CYP2E1, ALDH2, NAT2
41acetaminophen46 3 52 25 1212.8NAT2, CYP2E1, CYP2A6
42cyclophosphamide46 52 1210.8ADH1C, NAT2, CYP2E1, CYP2A6
43acetaldehyde30 46 2510.5CYP2E1, ADH1C, ADH1B, ALDH2, CYP2A6
44NADP258.5ADH1B, ALDH2, CYP2A6, ADH1C, CYP2E1
45nadph46 259.5ALDH2, ADH1B, CYP2E1, CYP2A6, ADH1C
46Water258.4ALDH2, CYP2A6, CYP2E1, ADH1B, ADH1C
47dopamine46 30 25 1211.4ALDH2, ADH1B, CYP2E1, CYP2A6
48rsai468.2ALDH2, ADH1B, ADH1C, NAT2, CYP2E1
49ethanol46 52 25 1211.2ADH1B, ADH1C, AHSG, CYP2E1, ADH4, ALDH2
50vitamin a46 25 129.9CYP2E1, NAT2, ADH1C, ADH4, ADH1B, ALDH2

GO Terms for genes affiliated with Alcoholic Liver Cirrhosis

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Sources:
17Gene Ontology
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Biological processes related to Alcoholic Liver Cirrhosis according to GeneCards/GeneDecks:

idNameGO IDScoreTop Affiliating Genes
1steroid metabolic processGO:0082029.5CYP2A6, CYP2E1
2alcohol metabolic processGO:0060669.4ADH4, ALDH2
3drug metabolic processGO:0171449.2CYP2A6, CYP2E1
4ethanol oxidationGO:0060698.7ADH1C, ADH4, ADH1B, ALDH2
5xenobiotic metabolic processGO:0068057.0CYP2A6, CYP2E1, NAT2, ADH1C, ADH4, ADH1B
6small molecule metabolic processGO:0442816.9ADH1B, ADH4, ADH1C, NAT2, CYP2E1, ALDH2

Molecular functions related to Alcoholic Liver Cirrhosis according to GeneCards/GeneDecks:

idNameGO IDScoreTop Affiliating Genes
1alcohol dehydrogenase activity, zinc-dependentGO:0040249.6ADH1B, ADH4
2oxidoreductase activity, acting on paired donors, with incorporation or reduction of molecular oxygen, reduced flavin or flavoprotein as one donor, and incorporation of one atom of oxygenGO:0167129.5CYP2E1, CYP2A6
3alcohol dehydrogenase (NAD) activityGO:0040229.5ADH4, ADH1C

Products for genes affiliated with Alcoholic Liver Cirrhosis

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  • Antibodies
  • Proteins
  • Lysates
  • Antibodies

Sources for Alcoholic Liver Cirrhosis

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4CDC
14ExPASy
15FMA
23GTR
24HGMD
25HMDB
26ICD10
27ICD10 via Orphanet
28ICD9CM
30IUPHAR
31KEGG
36MeSH
37MESH via Orphanet
38MGI
41NCIt
42NDF-RT
45NINDS
46Novoseek
48OMIM
49OMIM via Orphanet
53PubMed
54QIAGEN
60SNOMED-CT via Orphanet
63UMLS
64UMLS via Orphanet