MCID: ALC009
MIFTS: 48

Alcoholic Liver Cirrhosis

Categories: Gastrointestinal diseases, Liver diseases

Aliases & Classifications for Alcoholic Liver Cirrhosis

MalaCards integrated aliases for Alcoholic Liver Cirrhosis:

Name: Alcoholic Liver Cirrhosis 38 12 14
Portal Cirrhosis 12 52 69
Liver Cirrhosis, Alcoholic 42 69
Alcoholic Cirrhosis 12 52
Laennec's Cirrhosis, Alcoholic 12
Alcoholic Cirrhosis of Liver 12
Laennec's Cirrhosis 12

Classifications:



External Ids:

Disease Ontology 12 DOID:14018
ICD10 33 K70.3
ICD9CM 35 571.2
MeSH 42 D008104
NCIt 47 C34782
UMLS 69 C0023891

Summaries for Alcoholic Liver Cirrhosis

MalaCards based summary : Alcoholic Liver Cirrhosis, also known as portal cirrhosis, is related to alcohol abuse and liver cirrhosis, and has symptoms including icterus An important gene associated with Alcoholic Liver Cirrhosis is ADH1B (Alcohol Dehydrogenase 1B (Class I), Beta Polypeptide), and among its related pathways/superpathways are Metabolism and Cytochrome P450 - arranged by substrate type. The drugs Losartan and Propranolol have been mentioned in the context of this disorder. Affiliated tissues include Liver, liver and bone, and related phenotype is homeostasis/metabolism.

Related Diseases for Alcoholic Liver Cirrhosis

Diseases related to Alcoholic Liver Cirrhosis via text searches within MalaCards or GeneCards Suite gene sharing:

(show top 50) (show all 110)
id Related Disease Score Top Affiliating Genes
1 alcohol abuse 30.0 CXCL8 F2 TF
2 liver cirrhosis 10.9
3 classic progressive supranuclear palsy syndrome 10.8 CYP2E1 NAT2
4 subleukemic leukemia 10.7 ALDH2 CYP2E1
5 atrial septal defect 6 10.7 ADH1B ADH1C
6 non-hodgkin lymphoma, during pregnancy 10.7 ALB F2
7 fragile x syndrome type 2 10.6 ALB F2
8 oral cavity carcinoma in situ 10.6 ALB F2
9 optic nerve glioma 10.6 ADH1B ALDH2 CYP2E1
10 lethal hydranencephaly-diaphragmatic hernia syndrome 10.6 ADH1B ADH1C CYP2E1
11 pancreatic cystadenocarcinoma 10.6 ALB F2
12 lymph node palisaded myofibroblastoma 10.6 CXCL8 GSTM1
13 male genital organ stricture 10.6 ALB TF
14 measles 10.5 ALDH2 CYP2E1 GSTM1
15 duane retraction syndrome 10.5 ALB F2
16 adie pupil 10.5 ALB TF
17 capillary leak syndrome 10.5 ALB CXCL8
18 chronic inflammatory demyelinating polyneuritis 10.5 ALB F2
19 tropical calcific pancreatitis 10.5 ADH1B ADH1C ALDH2
20 angelucci's syndrome 10.5 ALB F2
21 epiphora due to excess lacrimation 10.5 F2 TF
22 emery-dreifuss muscular dystrophy, dominant type 10.5 CYP2E1 GSTM1 NAT2
23 atrophic vulva 10.5 ALB F2
24 hypothyroidism due to deficient transcription factors involved in pituitary development or function 10.4 GSTM1 NAT2
25 bronchiolo-alveolar adenocarcinoma 10.4 AHSG F2
26 labyrinthine bilateral reactive loss 10.4 ALB CXCL8
27 halal setton wang syndrome 10.4 CXCL8 TF
28 pellagra 10.4 ALB TF
29 yellow fever 10.4 ALB CXCL8
30 hepatitis 10.4
31 cerebral sarcoidosis 10.3 ALB TF
32 mediastinum leiomyoma 10.3 ALB F2 TF
33 spinocerebellar ataxia 8 10.3 ALB F2 TF
34 lacrimal system cancer 10.2 ALB F2 TF
35 dentinogenesis imperfecta 10.2 ALB CXCL8 F2
36 mixed mineral dust pneumoconiosis 10.2 ALB CXCL8 F2
37 parkinsonism-dystonia, infantile 10.2 ALDH2 CYP2A6 GSTM1
38 scabies 10.2 ALB CXCL8 F2
39 tuberculum sellae meningioma 10.2 ALB CXCL8 F2
40 bicipital tenosynovitis 10.2 ADH4 ALDH2
41 hyperpigmentation of eyelid 10.2 ALB CXCL8 TF
42 extratemporal epilepsy 10.2 ADH4 ALDH2
43 sleep disorder 10.2 AHSG ALB TF
44 lambert-eaton myasthenic syndrome 10.2 AHSG F2 TF
45 intramuscular hemangioma 10.2 AHSG ALB TF
46 tonsil cancer 10.1 ALB SLC17A5
47 childhood brain stem glioma 10.1 ALB F2
48 pancreatitis 10.1
49 hepatocellular carcinoma 10.1
50 hypocalcemia, autosomal dominant 2 10.1 ADH1B ADH4

Comorbidity relations with Alcoholic Liver Cirrhosis via Phenotypic Disease Network (PDN): (show all 26)


Acquired Thrombocytopenia Active Peptic Ulcer Disease
Acute Cystitis Acute Kidney Failure
Acute Pancreatitis Alcohol Abuse
Alcoholic Cardiomyopathy Alcoholic Gastritis
Alcoholic Hepatitis Alcoholic Neuropathy
Chronic Congestive Splenomegaly Chronic Kidney Failure
Deficiency Anemia Esophageal Varix
Familial Atrial Fibrillation Fatty Liver Disease
Heart Disease Hepatic Encephalopathy
Hepatocellular Carcinoma Hepatorenal Syndrome
Hypersplenism Iron Deficiency Anemia
Portal Hypertension Protein-Energy Malnutrition
Respiratory Failure Urea Cycle Disorder

Graphical network of the top 20 diseases related to Alcoholic Liver Cirrhosis:



Diseases related to Alcoholic Liver Cirrhosis

Symptoms & Phenotypes for Alcoholic Liver Cirrhosis

UMLS symptoms related to Alcoholic Liver Cirrhosis:


icterus

MGI Mouse Phenotypes related to Alcoholic Liver Cirrhosis:

44
id Description MGI Source Accession Score Top Affiliating Genes
1 homeostasis/metabolism MP:0005376 9.32 NAT2 PNPLA3 SLC17A5 TF ADH1C AHSG

Drugs & Therapeutics for Alcoholic Liver Cirrhosis

Drugs for Alcoholic Liver Cirrhosis (from DrugBank, HMDB, Dgidb, PharmGKB, IUPHAR, NovoSeek, BitterDB):

(show top 50) (show all 154)
id Name Status Phase Clinical Trials Cas Number PubChem Id
1
Losartan Approved Phase 4,Phase 3 114798-26-4 3961
2
Propranolol Approved, Investigational Phase 4,Phase 3 525-66-6 4946
3
Ethanol Approved Phase 4,Phase 3,Phase 1,Phase 2 64-17-5 702
4
Spironolactone Approved Phase 4 1952-01-7, 52-01-7 5833
5
Gabapentin Approved, Investigational Phase 4 60142-96-3 3446
6
Metformin Approved Phase 4 657-24-9 14219 4091
7
Folic Acid Approved, Nutraceutical, Vet_approved Phase 4 59-30-3 6037
8
Pyridoxal Approved, Nutraceutical Phase 4 66-72-8 1050
9
Pyridoxine Approved, Nutraceutical, Vet_approved Phase 4 65-23-6 1054
10
Angiotensin II Investigational Phase 4,Phase 3,Phase 1,Phase 2 68521-88-0, 4474-91-3, 11128-99-7 172198 65143
11
gamma-Aminobutyric acid Investigational Phase 4 56-12-2 119
12 Angiotensin II Type 1 Receptor Blockers Phase 4,Phase 3,Phase 1,Phase 2
13 Angiotensin Receptor Antagonists Phase 4,Phase 3,Phase 1,Phase 2
14 Angiotensinogen Phase 4,Phase 3,Phase 1,Phase 2
15 Anti-Arrhythmia Agents Phase 4,Phase 3
16 Antihypertensive Agents Phase 4,Phase 3,Phase 1,Phase 2
17 Liver Extracts Phase 4,Phase 3,Phase 2,Phase 1
18 Anti-Infective Agents Phase 4,Phase 3,Phase 2,Phase 1,Early Phase 1
19 Neurotransmitter Agents Phase 4,Phase 3
20 Micronutrients Phase 4,Phase 3
21 Trace Elements Phase 4,Phase 3
22 Vitamins Phase 4,Phase 3
23 Adrenergic Agents Phase 4,Phase 3
24 Adrenergic Antagonists Phase 4,Phase 3
25 Adrenergic beta-Antagonists Phase 4,Phase 3
26 Vasodilator Agents Phase 4,Phase 3,Phase 2,Phase 1
27 Anti-Infective Agents, Local Phase 4,Phase 3
28 Central Nervous System Depressants Phase 4,Phase 3
29 diuretics Phase 4,Phase 2,Phase 3
30 Hormone Antagonists Phase 4,Phase 2,Phase 3
31 Hormones Phase 4,Phase 2,Phase 3
32 Hormones, Hormone Substitutes, and Hormone Antagonists Phase 4,Phase 2,Phase 3
33 Analgesics Phase 4
34 Anti-Anxiety Agents Phase 4
35 Anticonvulsants Phase 4
36 Antimanic Agents Phase 4
37 Antiparkinson Agents Phase 4
38 calcium channel blockers Phase 4
39 Calcium, Dietary Phase 4
40 Excitatory Amino Acid Antagonists Phase 4
41 Excitatory Amino Acids Phase 4
42 GABA Agents Phase 4
43 Peripheral Nervous System Agents Phase 4,Phase 3,Phase 2
44 Psychotropic Drugs Phase 4
45 Tranquilizing Agents Phase 4
46 Metadoxine Phase 4
47 Vitamin B 6 Phase 4
48 Vitamin B Complex Phase 4
49 Diuretics, Potassium Sparing Phase 4
50 Mineralocorticoid Receptor Antagonists Phase 4

Interventional clinical trials:

(show top 50) (show all 74)

id Name Status NCT ID Phase Drugs
1 Prevention of Decompensation in Liver Cirrhosis Unknown status NCT00239096 Phase 4 losartan (drug)
2 Treatment for Alcohol Dependence With Gabapentin Recruiting NCT02771925 Phase 4 Gabapentin 2g/day divided in two doses for 24 weeks;Placebo 2g/day divided in two doses for 24 weeks
3 Effect of Metadoxine on Oxidative Stress in Non-alcoholic Hepatic Steatosis Recruiting NCT02051842 Phase 4 Metadoxine
4 Hemodynamic Effects of Chronic Administration of Spironolactone and/or Propranolol in Alcoholic Cirrhotic Patients Terminated NCT00188045 Phase 4 Propranolol - Spironolactone
5 Probiotics for Portal Hypertension Unknown status NCT01134692 Phase 3 Propranolol, Norfloxacin, VSL#3
6 Tenofovir Versus Lamivudine for Patients of Chronic Hepatitis B With Severe Acute Exacerbation Unknown status NCT01848743 Phase 3 Tenofovir;lamivudine
7 Effect on Liver Histology of Vitamin D in Patients With Non-alcoholic Steatohepatitis Unknown status NCT01623024 Phase 3 Vitamin D
8 Baclofen in the Treatment of Alcohol Dependence With or Without Alcoholic Liver Disease Completed NCT01711125 Phase 3 Baclofen 30mg/day;Baclofen 75mg/day;Placebo
9 Granulocyte Colony Stimulating Factor And Growth Hormone In Cirrhosis Of Liver: An Open Label Study Completed NCT02451033 Phase 2, Phase 3 standard medical therapy;G-CSF;Growth Hormone
10 Treatment of Severe Alcoholic Hepatitis With Corticoids Plus N Acetyl Cysteine Versus Corticoids Alone Completed NCT00863785 Phase 3 Corticoids plus N Acetyl Cysteine
11 Anti-Fibrotic Effects of Losartan In Nash Evaluation Study Completed NCT01051219 Phase 3 Losartan
12 Trial for Hepatocellular Carcinoma Adjuvant Treatment by Lipiocis Completed NCT00116454 Phase 3 131 I-lipiodol
13 REnal Function in Liver Transplantation: Everolimus With Calcineurin Inhibitor (CNI)-Sparing sTrategy Recruiting NCT02115113 Phase 3 Everolimus;Everolimus;Tacrolimus
14 Proton Radiotherapy Versus Radiofrequency Ablation for Patients With Medium or Large Hepatocellular Carcinoma Recruiting NCT02640924 Phase 3
15 To Study the Effect of Nonselective Beta Blockers in Advanced Stage Liver Disease With Ascites Recruiting NCT02649335 Phase 3 Propranolol
16 Nalmefene in Patients With Alcoholic Compensated Cirrhosis for the Treatment of Alcohol Dependence. Not yet recruiting NCT02824354 Phase 3 Nalmefene (Selincro®) 18 mg tablet;placebo
17 Phlebotomy and Risk of Hepatocellular Carcinoma in Patients With Compensated Alcoholic Cirrhosis Terminated NCT01342705 Phase 3
18 The Effectiveness and Safety for Mesenchymal Stem Cell for Alcoholic Liver Cirrhosis Unknown status NCT01741090 Phase 2
19 REVIVE(Randomized Exploratory Clinical Trial to Evaluate the Safety and Effectiveness of Stem Cell Product in Alcoholic Liver Cirrhosis Patient) Completed NCT01875081 Phase 2
20 Dose Finding Study to Assess Safety and Efficacy of Stem Cells in Liver Cirrhosis Completed NCT01591200 Phase 2
21 A Phase II, Double-blinded, Randomized, Controlled Study to Evaluate the Efficacy and Safety of Vitalliver in Patients With Decompensated Cirrhosis Completed NCT00562783 Phase 2 Vitaliver;Placebo
22 Efficacy of Baclofen in the Treatment of Alcohol Addiction Completed NCT00525252 Phase 1, Phase 2 Baclofen;placebo
23 Effect of Candesartan in Alcoholic Liver Fibrosis Completed NCT00990639 Phase 1, Phase 2 candesartan for hepatic fibrosis
24 Use of F-652 in Patients With Alcoholic Hepatitis Recruiting NCT02655510 Phase 1, Phase 2 F-652
25 Selonsertib in Combination With Prednisolone Versus Prednisolone Alone in Participants With Severe Alcoholic Hepatitis (AH) Recruiting NCT02854631 Phase 2 Selonsertib;Prednisolone;Placebo
26 Long-term Follow-up Study of Livercellgram in Alcoholic Liver Cirrhosis Patients Who Completed Livercellgram Phase 2 Study Enrolling by invitation NCT02806011 Phase 2
27 Effects of Rifaximin in Patients With Acute Alcoholic Hepatitis Enrolling by invitation NCT02116556 Phase 2 Prednisone;Rifaximin
28 Pegfilgrastim in Patients With Alcoholic Hepatitis Not yet recruiting NCT02776059 Phase 2 Standard of care + pegfiltrastim;Standard of care
29 Pharmacokinetic and Pharmacodynamic Study of IDN-6556 in ACLF Terminated NCT01937130 Phase 2 IDN-6556
30 Pharmacokinetics (PK) of Tipranavir/Ritonavir, Ribavirin, Pegylated Interferon (Peg INF) in Hepatitis C (HCV) Subjects With Mild Hepatic Impairment and in HCV, Hepatitis B (HBV), Hepatitis D Infected Subjects or Alcoholic Cirrhosis With Moderate Hepatic I Completed NCT02259855 Phase 1 Tipranavir;Ritonavir;Pegylated interferon;Ribavirin
31 Pilot Study of Pentoxifylline for Hepatopulmonary Syndrome Terminated NCT00593658 Phase 1 pentoxifylline
32 Pangenomic Study During Alcoholic Cirrhosis Unknown status NCT01065233
33 Measurement of Fibrinogen in Patients With Systemic Inflammatory Response Syndrome (SIRS), Sepsis or Chronicle Liver Disease on Intensive Care Units (ICU) Unknown status NCT01169168
34 Prospective Analysis Of Cardiac Function In Cirrhotic Patients By Echocardiography And Its Correlation With Events Unknown status NCT01433848
35 FGL2/Fibroleukin and Hepatitis C Virus Recurrence Post Liver Transplantation Unknown status NCT00701272
36 The Efficacy of S-adenosyl Methionine (SAMe) Versus Pentoxiphylline in Patients With Non-alcoholic Steatohepatitis With Fibrosis Unknown status NCT02231333 S-adenosylmethionine (SAMe);pentoxiphylline (PTX)
37 Volatile Organic Compounds (VOCs) and Liver Diseases Unknown status NCT01279356
38 Acupuncture as an Adjunctive Treatment for Hepatitis C Patients Unknown status NCT01750515
39 Liver Transplantation Versus Alternative Therapies for Patients With Pugh B Alcoholic Cirrhosis Completed NCT00701792
40 Adipose Tissue Involvement in Alcohol-induced Liver Inflammation in Human Completed NCT00388323
41 Biomarkers for the Prognosis of Decompensated Alcoholic Liver Disease Completed NCT01701687
42 Randomised Open-label Multicenter Study Evaluating Ciprofloxacin in Severe Alcoholic Hepatitis Completed NCT02326103 Early Phase 1 Ciprofloxacin;Placebo
43 Influence of Probiotics on Infections in Cirrhosis Completed NCT01607528
44 Acoustic Liver Biopsy in Normals and in Patients With Cirrhosis Using Endoscopic Ultrasound Completed NCT01208311
45 FIBROSCAN Validation and Interest of Fibrotest - FIBROSCAN Association for Fibrosis Diagnosis in Alcoholic Liver Disease Completed NCT00708617
46 Subclinical Myocardial Dysfunction in Patients With Hepatic Cirrhosis Completed NCT01713478
47 THE IMMUNOLOGICAL EFFECTS AND METABOLIC TOLERANCE OF LIPID INFUSION IN PATIENTS WITH CIRRHOSIS. Completed NCT02381769
48 Influence of Adiponutrin in Chronic Liver Disease Completed NCT01122797
49 Evaluation of Liver Fibrosis Staging With Acoustic Radiation Force Impulse Elastography Completed NCT01283230
50 Indocyanine Green and Portal Pressure in Viral and Alcoholic Cirrhotic Patients With Hepatocarcinoma Recruiting NCT00827723

Search NIH Clinical Center for Alcoholic Liver Cirrhosis

Cell-based therapeutics:


LifeMap Discovery
Data from LifeMap, the Embryonic Development and Stem Cells Database
Read about Alcoholic Liver Cirrhosis cell therapies at LifeMap Discovery.
Stem-cell-based therapeutic approaches for Alcoholic Liver Cirrhosis:
Livercellgram, bone marrow-derived mesenchymal stem cells for treatment of alcoholic liver cirrhosis
Embryonic/Adult Cultured Cells Related to Alcoholic Liver Cirrhosis:
Bone marrow-derived mesenchymal stem cells

Cochrane evidence based reviews: liver cirrhosis, alcoholic

Genetic Tests for Alcoholic Liver Cirrhosis

Anatomical Context for Alcoholic Liver Cirrhosis

MalaCards organs/tissues related to Alcoholic Liver Cirrhosis:

39
Liver, Bone, Skeletal Muscle, Bone Marrow, T Cells, Small Intestine, Monocytes
LifeMap Discovery
Data from LifeMap, the Embryonic Development and Stem Cells Database

Cells/anatomical compartments in embryo or adult related to Alcoholic Liver Cirrhosis:
id Tissue Anatomical CompartmentCell Relevance
1 Liver Liver Lobule Hepatocytes Affected by disease

Publications for Alcoholic Liver Cirrhosis

Articles related to Alcoholic Liver Cirrhosis:

(show top 50) (show all 248)
id Title Authors Year
1
Association between Serum Selenium Concentrations and Levels of Proinflammatory and Profibrotic Cytokines-Interleukin-6 and Growth Differentiation Factor-15, in Patients with Alcoholic Liver Cirrhosis. ( 28430124 )
2017
2
Disialo-Trisialo Bridging Phenomenon of Transferrin Isoform Detected by Capillary Electrophoresis in Patient with Alcoholic Liver Cirrhosis: First Case Report from Asia. ( 28271694 )
2017
3
Data on gut metagenomes of the patients with alcoholic dependence syndrome and alcoholic liver cirrhosis. ( 28138508 )
2017
4
Characterization of Body Composition and Definition of Sarcopenia in Patients with Alcoholic Liver Cirrhosis: a Computed Tomography Based Study. ( 28665532 )
2017
5
A tip from the nose: rhinocerebral mucormycosis in a patient with alcoholic liver cirrhosis and cocaine abuse, an uncommon association. ( 28784893 )
2017
6
Diagnostic specificity and sensitivity of PIVKAII, GP3, CSTB, SCCA1 and HGF for the diagnosis of hepatocellular carcinoma in patients with alcoholic liver cirrhosis. ( 28766361 )
2017
7
Cost of illness of non-alcoholic liver cirrhosis in Japan: A time trend analysis and future projections. ( 28497644 )
2017
8
Bacteremia Caused by Campylobacter Fetus in a Patient With Hepatitis B Virus Infection Complicated with Alcoholic Liver Cirrhosis. ( 28879715 )
2017
9
Reduced platelet activation and platelet aggregation in patients with alcoholic liver cirrhosis. ( 28895774 )
2017
10
A Single Nucleotide Polymorphism in the RASGRF2 Gene Is Associated with Alcoholic Liver Cirrhosis in Men. ( 27992614 )
2016
11
Length of Variable Numbers of Tandem Repeats in the Carboxyl Ester Lipase (CEL) Gene May Confer Susceptibility to Alcoholic Liver Cirrhosis but Not Alcoholic Chronic Pancreatitis. ( 27802312 )
2016
12
Lispro insulin in people with non-alcoholic liver cirrhosis and type 2 diabetes mellitus. ( 26803356 )
2016
13
Behavior of Oxidative Stress Markers in Alcoholic Liver Cirrhosis Patients. ( 28074118 )
2016
14
Letter to the editor: treatment for superficial esophageal cancer with rectal varices bleeding in a patient with alcoholic liver cirrhosis. ( 26728025 )
2016
15
Henoch-SchAPnlein purpura nephritis and colitis in an adult patient with alcoholic liver cirrhosis. ( 27668165 )
2016
16
A study on hematological spectrum in patients with alcoholic liver cirrhosis. ( 27727674 )
2016
17
Risk for alcoholic liver cirrhosis after an initial hospital contact with alcohol problems: A nationwide prospective cohort study. ( 27862159 )
2016
18
Serum Concentrations of Selected Heavy Metals in Patients with Alcoholic Liver Cirrhosis from the Lublin Region in Eastern Poland. ( 27304961 )
2016
19
Confluent hepatic fibrosis in alcohol liver cirrhosis with elevated pivkaii value - usefulness of immunostaining for EZH2 and p16(INK4a) in differentiating it from cholangiolocellular carcinoma - Confluent hepatic fibrosis. ( 27418411 )
2016
20
CLIF-SOFA score and SIRS are independent prognostic factors in patients with hepatic encephalopathy due to alcoholic liver cirrhosis. ( 27367990 )
2016
21
Aldehyde Dehydrogenase 2 (ALDH2) Polymorphism and the Risk of Alcoholic Liver Cirrhosis among East Asians: A Meta-Analysis. ( 27189280 )
2016
22
Concentrations of fetuin-A, osteoprotegerin and I+-Klotho in patients with alcoholic liver cirrhosis. ( 27882180 )
2016
23
Alcohol dehydrogenase 1C (ADH1C) gene polymorphism and alcoholic liver cirrhosis risk: a meta analysis. ( 26379912 )
2015
24
Genetic polymorphism in alcohol dehydrogenase 2 (ADH2) gene and alcoholic liver cirrhosis risk. ( 26221330 )
2015
25
Aldehyde dehydrogenase 2 polymorphism influences development to hepatocellular carcinoma in East Asian alcoholic liver cirrhosis. ( 25778454 )
2015
26
Activity of MMP1 and MMP13 and Amino Acid Metabolism in Patients with Alcoholic Liver Cirrhosis. ( 25863779 )
2015
27
A variant in the nuclear dot protein 52kDa gene increases the risk for spontaneous bacterial peritonitis in patients with alcoholic liver cirrhosis. ( 26493630 )
2015
28
Circulating Lipids Are Associated with Alcoholic Liver Cirrhosis and Represent Potential Biomarkers for Risk Assessment. ( 26107182 )
2015
29
Alcohol drinking pattern and risk of alcoholic liver cirrhosis: A prospective cohort study. ( 25634330 )
2015
30
Predictors of hepatorenal syndrome in alcoholic liver cirrhosis. ( 25820623 )
2015
31
Plasma osteopontin is a biomarker for the severity of alcoholic liver cirrhosis, not for hepatocellular carcinoma screening. ( 26122937 )
2015
32
Alcoholic Liver Cirrhosis and Significant Risk Factors for the Development of Alcohol-related Hepatocellular Carcinoma--Japan, 2012. ( 26946783 )
2015
33
Flavobacterium ceti From Blood Samples of a Korean Patient With Alcoholic Liver Cirrhosis. ( 25932454 )
2015
34
Alcohol abuse and alcoholic liver cirrhosis leading to spontaneous muscle hematoma: an event fraught with danger. ( 25969676 )
2015
35
Proinflammatory Cytokines (IL-1I+, IL-6) and Hepatocyte Growth Factor in Patients with Alcoholic Liver Cirrhosis. ( 26448742 )
2015
36
Hypothyroidism Enhanced Portal Hypertension in a Patient with Alcoholic Liver Cirrhosis, Resulting in the Development of Ascites. ( 26370856 )
2015
37
Systematic review with meta-analysis: the I148M variant of patatin-like phospholipase domain-containing 3 gene (PNPLA3) is significantly associated with alcoholic liver cirrhosis. ( 25060292 )
2014
38
Evidence of degraded BMD and geometry at the proximal femora in male patients with alcoholic liver cirrhosis. ( 25172381 )
2014
39
Successful treatment of invasive gastric mucormycosis in a patient with alcoholic liver cirrhosis: A case report. ( 25009590 )
2014
40
Interleukin 10 promoter haplotype is associated with alcoholic liver cirrhosis in Taiwanese patients. ( 24835349 )
2014
41
Correlation between hepatic blood flow and liver function in alcoholic liver cirrhosis. ( 25493018 )
2014
42
Vitamin D status, bone metabolism and bone mass in patients with alcoholic liver cirrhosis. ( 25318918 )
2014
43
Septic shock due to Aeromonas hydrophila bacteremia in a patient with alcoholic liver cirrhosis: a case report. ( 25464981 )
2014
44
Lacosamide as add-on treatment of focal symptomatic epilepsy in a patient with alcoholic liver cirrhosis. ( 25667897 )
2014
45
Portosystemic shunt via the superior mesenteric and right ovarian vein leading to small intestine bleeding in alcoholic liver cirrhosis. ( 23513021 )
2013
46
Alcoholic liver cirrhosis increases the risk of left ventricular diastolic dysfunction. ( 24362094 )
2013
47
Evaluation of periodontal status in alcoholic liver cirrhosis patients: a comparative study. ( 23811642 )
2013
48
Abnormalities in the serum phospholipids fatty acid profile in patients with alcoholic liver cirrhosis - a pilot study. ( 23874070 )
2013
49
Diagnostic significance of nitrates and nitrites and L-arginine, in development of hepatorenal syndrome in patients with end stage alcoholic liver cirrhosis. ( 23651488 )
2013
50
Serum amyloid A and C-reactive protein positive nodule in alcoholic liver cirrhosis, hard to make definite diagnosis. ( 23607539 )
2013

Variations for Alcoholic Liver Cirrhosis

Expression for Alcoholic Liver Cirrhosis

Search GEO for disease gene expression data for Alcoholic Liver Cirrhosis.

Pathways for Alcoholic Liver Cirrhosis

Pathways related to Alcoholic Liver Cirrhosis according to GeneCards Suite gene sharing:

(show all 16)
id Super pathways Score Top Affiliating Genes
1
Show member pathways
13.87 ADH1B ADH1C ADH4 ALB ALDH2 CYP2A6
2
Show member pathways
12.86 ADH1B ADH1C ADH4 ALDH2 CYP2A6 CYP2E1
3
Show member pathways
12.44 ADH1B ADH1C ADH4 ALDH2
4
Show member pathways
12 ADH1B ALDH2 CYP2A6 CYP2E1
5
Show member pathways
11.81 ADH1B ADH1C ADH4 ALDH2 CYP2A6 CYP2E1
6
Show member pathways
11.63 ADH1B ADH1C ADH4 ALDH2
7
Show member pathways
11.58 CYP2A6 CYP2E1 GSTM1
8
Show member pathways
11.55 ADH1B ADH1C ADH4
9
Show member pathways
11.04 CYP2A6 CYP2E1 NAT2
10 10.96 CYP2A6 CYP2E1 GSTM1
11 10.85 CYP2A6 CYP2E1
12
Show member pathways
10.75 ADH1B ADH1C ADH4 ALDH2
13 10.64 ADH1B ADH1C
14
Show member pathways
10.64 ADH1B ADH4 ALDH2
15
Show member pathways
10.37 ADH1B CYP2A6 CYP2E1
16 10.26 CYP2E1 GSTM1

GO Terms for Alcoholic Liver Cirrhosis

Cellular components related to Alcoholic Liver Cirrhosis according to GeneCards Suite gene sharing:

id Name GO ID Score Top Affiliating Genes
1 endoplasmic reticulum lumen GO:0005788 9.26 AHSG ALB F2 TF
2 blood microparticle GO:0072562 8.92 AHSG ALB F2 TF

Biological processes related to Alcoholic Liver Cirrhosis according to GeneCards Suite gene sharing:

id Name GO ID Score Top Affiliating Genes
1 cellular protein metabolic process GO:0044267 9.56 AHSG ALB F2 TF
2 platelet degranulation GO:0002576 9.5 AHSG ALB TF
3 oxidation-reduction process GO:0055114 9.43 ADH1B ADH1C ADH4 ALDH2 CYP2A6 CYP2E1
4 drug metabolic process GO:0017144 9.4 CYP2A6 CYP2E1
5 epoxygenase P450 pathway GO:0019373 9.37 CYP2A6 CYP2E1
6 alcohol metabolic process GO:0006066 9.16 ADH4 ALDH2
7 ethanol oxidation GO:0006069 8.92 ADH1B ADH1C ADH4 ALDH2

Molecular functions related to Alcoholic Liver Cirrhosis according to GeneCards Suite gene sharing:

id Name GO ID Score Top Affiliating Genes
1 oxidoreductase activity GO:0016491 9.43 ADH1B ADH1C ADH4 ALDH2 CYP2A6 CYP2E1
2 oxidoreductase activity, acting on paired donors, with incorporation or reduction of molecular oxygen, reduced flavin or flavoprotein as one donor, and incorporation of one atom of oxygen GO:0016712 9.37 CYP2A6 CYP2E1
3 retinol dehydrogenase activity GO:0004745 9.32 ADH1C ADH4
4 arachidonic acid epoxygenase activity GO:0008392 9.26 CYP2A6 CYP2E1
5 alcohol dehydrogenase (NAD) activity GO:0004022 9.16 ADH1C ADH4
6 alcohol dehydrogenase activity, zinc-dependent GO:0004024 8.8 ADH1B ADH1C ADH4

Sources for Alcoholic Liver Cirrhosis

3 CDC
7 CNVD
9 Cosmic
10 dbSNP
11 DGIdb
16 ExPASy
18 FMA
28 GO
29 GTR
30 HGMD
31 HMDB
32 HPO
33 ICD10
34 ICD10 via Orphanet
35 ICD9CM
36 IUPHAR
37 KEGG
38 LifeMap
40 MedGen
42 MeSH
43 MESH via Orphanet
44 MGI
46 NCI
47 NCIt
48 NDF-RT
51 NINDS
52 Novoseek
54 OMIM
55 OMIM via Orphanet
59 PubMed
60 QIAGEN
65 SNOMED-CT via HPO
66 SNOMED-CT via Orphanet
67 TGDB
68 Tocris
69 UMLS
70 UMLS via Orphanet
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