MCID: ALC009
MIFTS: 52

Alcoholic Liver Cirrhosis malady

Gastrointestinal, Liver categories

Summaries for Alcoholic Liver Cirrhosis

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33MalaCards
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MalaCards: Alcoholic Liver Cirrhosis, also known as portal cirrhosis, is related to hepatitis c and alcoholic pancreatitis. An important gene associated with Alcoholic Liver Cirrhosis is ADH1C (alcohol dehydrogenase 1C (class I), gamma polypeptide), and among its related pathways are Doxepin Pathway, Pharmacokinetics and phenylalanine utilization. The compounds 4-Iodopyrazole and 1-methylxanthine have been mentioned in the context of this disorder. Affiliated tissues include skin, liver and bone marrow, and related mouse phenotype homeostasis/metabolism.

Aliases & Classifications for Alcoholic Liver Cirrhosis

Sources:
8Disease Ontology, 10DISEASES, 45Novoseek, 61UMLS, 57SNOMED-CT, 40NCIt, 27ICD9CM, 35MeSH, 25ICD10
See all sources

Classifications:

Malacards categories (disease lists): (See all malacards categories)
Anatomical: Gastrointestinal, Liver


Aliases & Descriptions:

alcoholic liver cirrhosis 8 10
portal cirrhosis 8 45 61
alcoholic cirrhosis 8 45
laennec's cirrhosis, alcoholic 8
alcoholic cirrhosis of liver 8
portal cirrhosis unspecified 8
liver cirrhosis, alcoholic 61
laennec's cirrhosis 8


External Ids:

Disease Ontology8 DOID:14018
NCIt40 C34782
ICD9CM27 571.2
MeSH35 D008104
ICD1025 K70.3

Related Diseases for Alcoholic Liver Cirrhosis

Sources:
17GeneCards, 18GeneDecks
See all sources

Diseases related to Alcoholic Liver Cirrhosis via text searches within MalaCards or GeneCards/GeneDecks gene sharing:

(show top 50)    (show all 97)
idRelated DiseaseScoreTop Affiliating Genes
1hepatitis c31.0ASGR2, LSL, CYP2E1
2alcoholic pancreatitis30.7ADH1C, AKR1A1, CYP2E1, ALDH2, ADH1B
3pancreatitis, chronic30.7ADH1B, AKR1A1, CYP2E1, ALDH2, ADH1C
4hepatitis b30.4TAT, ALDH2, NAT2, ASGR2
5fatty liver disease30.2CYP2E1
6alcohol dependence30.2ADH1B, ADH1A, ADH4, ADH7, ALDH2
7alcohol abuse30.2ALDH2, CYP2E1, AKR1A1, ADH1C
8viral hepatitis30.2ADH1B, CYP2A6, AKR1A1
9alcoholic hepatitis10.7
10hepatitis a10.7
11hepatitis c virus10.5
12hepatitis d10.4
13calciphylaxis10.3
14hepatitis e10.3
15hepatorenal syndrome10.3
16hepatic coma10.2
17megaloblastic anemia10.2
18acute liver failure10.2
19gilbert syndrome10.2
20primary biliary cirrhosis10.2
21hemochromatosis10.2
22portal hypertension10.2
23necrotizing fasciitis10.2
24alcoholic neuropathy10.2
25n syndrome10.2
26vitiligo10.2
27non-a-e hepatitis10.2
28hyperprolinemia10.2
29nonalcoholic steatohepatitis10.2
30bacteremia10.2
31sepsis10.2
32venous thrombosis10.2
33insulin resistance10.2
34varicose veins10.2
35serotonin syndrome10.2
36tuberculous peritonitis10.0
37siderosis10.0
38membranoproliferative glomerulonephritis10.0
39acrodermatitis10.0
40extrahepatic cholestasis10.0
41cellulitis10.0
42hemosiderosis10.0
43pseudomyxoma peritonei10.0
44amyloid tumor10.0
45progressive multifocal leukoencephalopathy10.0
46hypoglycemia10.0
47acrodermatitis enteropathica10.0
48enteropathica10.0
49insulin autoimmune syndrome10.0
50spastic paraparesis10.0

Graphical network of the top 20 diseases related to Alcoholic Liver Cirrhosis:



Diseases related to alcoholic liver cirrhosis

Clinical Features for Alcoholic Liver Cirrhosis

Drugs & Therapeutics for Alcoholic Liver Cirrhosis

Sources:
5CenterWatch, 42NIH Clinical Center, 6ClinicalTrials, 61UMLS, 41NDF-RT
See all sources

Approved drugs:

Search CenterWatch for Alcoholic Liver Cirrhosis

Drug clinical trials:

Search ClinicalTrials for Alcoholic Liver Cirrhosis

Search NIH Clinical Center for Alcoholic Liver Cirrhosis

Search CenterWatch for Alcoholic Liver Cirrhosis

Genetic Tests for Alcoholic Liver Cirrhosis

Anatomical Context for Alcoholic Liver Cirrhosis

Sources:
31LifeMap Discovery™, 33MalaCards
See all sources

MalaCards organs/tissues related to Alcoholic Liver Cirrhosis:

33
Skin, Liver, Bone marrow, Small intestine, Thyroid, Monocytes, T cells, B cells, Bronchial epithelium

LifeMap Discovery
The database of embryonic development, stem cell research and regenerative medicine

Cells/anatomical compartments in embryo or adult related to Alcoholic Liver Cirrhosis:
id TissueAnatomical CompartmentCell Relevance
1 LiverLiver LobuleHepatocytes Affected by disease

Animal Models for Alcoholic Liver Cirrhosis or affiliated genes

Sources:
37MGI, 28inGenious Targeting Laboratory
See all sources

MGI Mouse Phenotypes related to Alcoholic Liver Cirrhosis:

37
idDescriptionMGI Source AccessionScoreTop Affiliating Genes
1MP:00053769.7GSTM1, AKR1A1, GHRH, AHSG, CYP2E1, NAT2

Publications for Alcoholic Liver Cirrhosis

Sources:
51PubMed
See all sources

Articles related to Alcoholic Liver Cirrhosis:

(show top 50)    (show all 237)
idTitleAuthorsYear
1
Portosystemic shunt via the superior mesenteric and right ovarian vein leading to small intestine bleeding in alcoholic liver cirrhosis. (23513021)
2013
2
Different patterns of decompensation in patients with alcoholic vs. non-alcoholic liver cirrhosis. (22530565)
2012
3
Iliopsoas muscle hematoma secondary to alcoholic liver cirrhosis. (23185153)
2012
4
Diagnostical significance of dimethylarginine in the development of hepatorenal syndrome in patients with alcoholic liver cirrhosis. (22924265)
2012
5
Common polymorphism in the PNPLA3/adiponutrin gene confers higher risk of cirrhosis and liver damage in alcoholic liver disease. (21334404)
2011
6
Genetic polymorphism at codon 10 of the transforming growth factor-I^1 gene in patients with alcoholic liver cirrhosis. (21494076)
2011
7
Clinical utility of red cell distribution width in alcoholic and non-alcoholic liver cirrhosis. (22220466)
2011
8
Complications of alcoholic liver cirrhosis: active assessment by endoscopy and sonography. (20672382)
2010
9
Outcomes of liver transplantation in patients with cirrhosis due to nonalcoholic steatohepatitis versus patients with cirrhosis due to alcoholic liver disease. (20373463)
2010
10
Alcoholic fatty liver disease and alcoholic liver cirrhosis may be differentiated with mean platelet volume and platelet distribution width. (20672909)
2010
11
Outcomes of liver transplantation in patients with cirrhosis due to nonalcoholic steatohepatitis versus patients with cirrhosis due to alcoholic liver disease. (19938128)
2009
12
Hypergammaglobulinaemic purpura associated with alcoholic liver cirrhosis. (20055836)
2009
13
Increased immunoglobulin A in alcoholic liver cirrhosis: exploring the response of B cells to Toll-like receptor 9 activation. (19737238)
2009
14
Autologous infusion of expanded mobilized adult bone marrow-derived CD34+ cells into patients with alcoholic liver cirrhosis. (18637092)
2008
15
Abstinence in patients with alcoholic liver cirrhosis: A follow-up study. (18507691)
2008
16
Clinical challenges and images in GI. Image 2. Perforative peritonitis on sclerosing encapsulating peritonitis (abdominal cocoon) in a patient with alcoholic liver cirrhosis. (17383416)
2007
17
-238 G>A polymorphism of tumor necrosis factor alpha gene (TNFA) is associated with alcoholic liver cirrhosis in alcoholic Spanish men. (16340448)
2005
18
Asialoglycoprotein receptor facilitates hemolysis in patients with alcoholic liver cirrhosis. (15122769)
2004
19
Polymorphisms in the DNA repair gene XRCC1 and susceptibility to alcoholic liver cirrhosis in older Southeastern Brazilians. (12175549)
2002
20
Indication of liver transplantation in severe alcoholic liver cirrhosis: quantitative evaluation and optimal timing. (11804670)
2002
21
Impaired accommodation of proximal stomach in patients with alcoholic liver cirrhosis. (12523589)
2002
22
Chinese alcoholic patients with esophageal cancer are genetically different from alcoholics with acute pancreatitis and liver cirrhosis. (11051375)
2000
23
Alterations of IGF-binding proteins in patients with alcoholic liver cirrhosis. (11091025)
2000
24
N-acetyltransferase-2, glutathione S-transferase M1, alcohol dehydrogenase, and cytochrome P450IIE1 genotypes in alcoholic liver cirrhosis: a case-control study. (10232877)
1999
25
Simultaneous elevation of serum amylase and lipase levels due to multiclass immunoglobulin-bound enzymes in a patient with alcoholic liver cirrhosis. (10231851)
1999
26
Orthotopic liver transplantation in alcoholic liver cirrhosis. (10500685)
1999
27
Hepatic veno-occlusive lesions in severe alcoholic hepatitis and alcoholic liver cirrhosis: a comparative histopathological study in autopsy cases. (10235278)
1999
28
Aeromonas sobria infection with severe soft tissue damage and segmental necrotizing gastroenteritis in a patient with alcoholic liver cirrhosis. (10469397)
1999
29
Influence of liver failure, ascites, and energy expenditure on the response to oral nutrition in alcoholic liver cirrhosis. (9263252)
1997
30
Survival in alcoholic liver cirrhosis: prognostic value of portal pressure, size of esophageal varices and biochemical data. Comparison with Child classification. (8776835)
1996
31
Effect of alcohol abuse and glutathione administration on the circulating levels of glutathione and on antipyrine metabolism in patients with alcoholic liver cirrhosis. (8869667)
1996
32
Impaired secretion and mRNA expression of monokines by alveolar macrophages from nonsmoking patients with alcoholic liver cirrhosis. (7876633)
1995
33
Genotypes of alcohol-metabolizing enzymes in Mexicans with alcoholic liver cirrhosis. (8845660)
1995
34
Circulating enzyme activities of collagen turnover and undulin in patients with various degrees of schistosomiasis and alcoholic liver cirrhosis. (7782029)
1995
35
Abnormal metabolism of S-adenosyl-L-methionine in hypoxic rat liver. Similarities to its abnormal metabolism in alcoholic cirrhosis. (8280752)
1994
36
Hepatitis C virus infection as a risk factor for non-alcoholic liver cirrhosis in Taiwan. (7508973)
1993
37
Alcoholic liver disease. Parenchyma to stroma relationship in fibrosis and cirrhosis as revealed by three-dimensional reconstruction and immunohistochemistry. (1378697)
1992
38
Mechanism of feminization in male patients with non-alcoholic liver cirrhosis: role of sex hormone-binding globulin. (1916151)
1991
39
Spontaneous regression of oesophageal varices after long-term conservative treatment. Retrospective study in 20 patients with alcoholic liver cirrhosis, posthepatitic cirrhosis and haemochromatosis with cirrhosis. (2332585)
1990
40
High interleukin-6 serum levels and increased production by leucocytes in alcoholic liver cirrhosis. Correlation with IgA serum levels and lymphokines production. (2505958)
1989
41
IgA nephropathy and alcoholic liver cirrhosis. A prospective necropsy study. (3369369)
1988
42
Hepatocyte and nuclear areas in alcoholic liver cirrhosis: their relationship with the size of the nodules and the degree of fibrosis. (3608794)
1987
43
Sexual dysfunction in men with alcoholic liver cirrhosis. A comparative study. (4039784)
1985
44
Decreased susceptibility of red blood cells to lipid peroxidation in patients with alcoholic liver cirrhosis. (3987030)
1985
45
T-cell subsets in peripheral blood and ascitic fluid of patients with alcoholic liver cirrhosis. (6136678)
1983
46
Liver disease in alcoholic cardiomyopathy: evidence against cirrhosis. (6840753)
1983
47
Prolactin and thyrotropin secretin in alcoholic liver cirrhosis: study of the variations induced by TRH, metoclopramide and cimetidine. (6796661)
1981
48
Human leucocyte antigens in patients with alcoholic liver cirrhosis. (7433893)
1980
49
Liver disease and alcohol: fatty liver, alcoholic hepatitis, cirrhosis, and their interrelationships. (50030)
1975
50
The "augmented secretin test" in patients with alcoholic liver cirrhosis. Preliminary report. (5525652)
1970

Genetic Variations for Alcoholic Liver Cirrhosis

Expression for genes affiliated with Alcoholic Liver Cirrhosis

Sources:
1BioGPS, 15Gene Expression Omnibus DataSets
See all sources
Expression patterns in normal tissues for genes affiliated with Alcoholic Liver Cirrhosis

Search GEO for disease gene expression data for Alcoholic Liver Cirrhosis.

Pathways for genes affiliated with Alcoholic Liver Cirrhosis

Sources:
50PharmGKB, 38NCBI BioSystems Database, 12EMD Millipore, 30KEGG, 54Reactome
See all sources

Pathways related to Alcoholic Liver Cirrhosis according to GeneCards/GeneDecks:

(show all 19)
idSuper pathways (with members indented)ScoreTop Affiliating Genes
1
Hide members
10.3ADH1B, ADH1A
2
Hide members
10.3ADH1B, ALDH2, ADH4
3
Hide members
10.3ADH1B, CYP2E1, ALDH2
4
Hide members
10.3CYP2E1, CYP2A6, ADH1B
5
Retinol metabolism
Hide members
10.3ALDH2, CYP2E1, CYP2A6
6
Acetaminophen metabolism
Hide members
10.3CYP2E1, CYP2A6, NAT2
7
Hide members
10.3NAT2, CYP2A6, CYP2E1
810.3ADH1A, CYP2E1, ADH4
910.3ADH1C, ADH1A, ADH1B
10
Hide members
10.2AKR1A1, CYP2A6, ALDH2, ADH1B
11
Naphthalene metabolism
Hide members
10.2GSTM1, CYP2A6, CYP2E1, AKR1A1
12
Hide members
10.2ADH1A, ADH1C, ADH7, ADH1B, ADH4
13
Hide members
10.1ALDH2, ADH7, ADH1B, ADH1C, ADH4, ADH1A
14
Hide members
10.1ADH4, ADH1A, ALDH2, ADH1C, ADH1B, ADH7
15
Hide members
10.0AKR1A1, ALDH2, ADH1A, ADH1C, ADH1B, ADH7
16
Hide members
9.9ADH1C, GSTM1, ADH7, ADH1B, ADH4, ADH1A
17
Hide members
9.9AKR1A1, CYP2E1, CYP2A6, ALDH2, ADH1A, ADH4
18
Hide members
9.8AKR1A1, CYP2E1, CYP2A6, NAT2, ALDH2, ADH1A
19
Hide members
9.8ADH7, ADH1B, ADH1C, ADH4, GSTM1, PLIN2

Compounds for genes affiliated with Alcoholic Liver Cirrhosis

Sources:
11DrugBank, 45Novoseek, 24HMDB, 50PharmGKB, 60Tocris Bioscience, 29IUPHAR
See all sources

Compounds related to Alcoholic Liver Cirrhosis according to GeneCards/GeneDecks:

(show top 50)    (show all 143)
idCompoundScoreTop Affiliating Genes
14-Iodopyrazole1110.7ADH1B, ADH1C, ADH1A
21-methylxanthine45 2411.7CYP2E1, CYP2A6, NAT2
34-methylpyrazole4510.7AKR1A1, CYP2E1, CYP2A6
4vinylchloride4510.7CYP2E1, ALDH2, GSTM1
5dimethylnitrosamine4510.7NAT2, CYP2A6, CYP2E1
6debrisoquine4510.6CYP2E1, GSTM1, NAT2, CYP2A6
7pyrazole45 1111.6AKR1A1, CYP2E1, ADH1C, CYP2A6
8mephenytoin45 50 1112.6CYP2A6, NAT2, CYP2E1
9trichloroethylene4510.6CYP2E1, GSTM1, NAT2, AKR1A1
10isoniazid50 45 1112.6CYP2E1, CYP2A6, NAT2, GSTM1
11mspi4510.6ADH1B, CYP2E1, NAT2, GSTM1
12gsts4510.6GSTM1, ALDH2, NAT2, CYP2E1
13Fomepizole1110.6CYP2A6, ADH1A, ADH1B, ADH1C, CYP2E1
14toluene4510.6CYP2E1, ALDH2, GSTM1
15styrene4510.6NAT2, GSTM1, CYP2E1
16betaine aldehyde45 2411.6ADH7, ADH1B, ADH1A, ALDH2, ADH1C
17midazolam45 50 1112.6NAT2, CYP2A6, GABRG2, CYP2E1
18disulfiram45 60 1112.6AKR1A1, CYP2E1, ALDH2, CYP2A6
191-hydroxypyrene4510.6CYP2E1, GSTM1, NAT2
20epoxide4510.6GSTM1, NAT2, AKR1A1, CYP2A6, CYP2E1
21rifampicin45 29 6012.6CYP2A6, CYP2E1, TAT, NAT2
22cimetidine45 29 1112.5AKR1A1, CYP2E1, CYP2A6, ADH7
23paraoxon45 2411.5CYP2E1, NAT2, CYP2A6
24formaldehyde45 2411.5CYP2E1, ADH1C, AKR1A1, CYP2A6, ESD, ALDH2
25betacarotene4510.5GSTM1, ALDH2, CYP2E1, NAT2
26Nicotinamide-Adenine-Dinucleotide1110.5AKR1A1, ADH1A, ADH7, ADH1B, ADH1C, ADH4
27polyacrylamide4510.5ALDH2, AHSG, AKR1A1, PGD, ESD, ADH1B
28benzyl alcohol45 1111.5CYP2E1, ALDH2, AKR1A1
29nad29 2411.5AKR1A1, ALDH2, ADH1A, ADH4, ADH1C, ADH1B
30acetaldehyde45 29 2412.4AKR1A1, CYP2E1, CYP2A6, ALDH2, ADH1A, ADH1C
31rsai4510.4ADH1B, ADH1C, ALDH2, NAT2, CYP2E1, AKR1A1
32dopamine45 29 11 2413.4ADH1B, GSTM1, ALDH2, AKR1A1, GHRH, CYP2E1
33nadh45 11 2412.4ADH1B, ADH1C, ADH4, ADH1A, ALDH2, PGD
34methotrexate45 50 1112.4TAT, GSTM1, PGD, NAT2, LSL
35aspartate4510.4AKR1A1, GHRH, PGD, TAT, ALDH2, GSTM1
364-hydroxynonenal45 2411.4GSTM1, AKR1A1, CYP2E1, ALDH2
37glucose4510.4GHRH, LSL, ADH1B, PGD, AHSG, ALDH2
38nadph45 2411.3ADH7, CYP2E1, CYP2A6, AKR1A1, PGD, ALDH2
39vitamin a45 11 2412.3AKR1A1, CYP2E1, NAT2, ALDH2, ADH1A, ADH4
40glycerol45 11 2412.3ADH1C, CYP2E1, ADH1B, TAT, LSL, AKR1A1
41cotinine45 2411.3NAT2, CYP2A6, GSTM1
42phenobarbital45 29 1112.3AKR1A1, CYP2E1, CYP2A6, GSTM1
43oxygen45 2411.3GSTM1, CYP2E1, AKR1A1, LSL, ALDH2, TAT
44lactate4510.3LSL, AKR1A1, CYP2E1, GSTM1, TAT, PGD
45retinoid4510.2ALDH2, ADH7, ADH4, ADH1A, AKR1A1
46retinoic acid45 2411.2ADH7, AKR1A1, ALDH2, ADH1A, TAT, CYP2A6
47nash4510.2AKR1A1, LSL, CYP2E1
48ethanol45 50 11 2413.1TAT, AHSG, GHRH, AKR1A1, ASGR2, ALDH2
49flurazepam45 1111.0CYP2E1, CYP2A6, GABRG2
50zinc45 2411.0ADH1A, TAT, ADH1C, LSL, ADH7, ADH1B

GO Terms for genes affiliated with Alcoholic Liver Cirrhosis

Sources:
16Gene Ontology
See all sources

Cellular components related to Alcoholic Liver Cirrhosis according to GeneCards/GeneDecks:

idNameGO IDScoreTop Affiliating Genes
1cytosolGO:0058299.8GSTM1, NAT2, PGD, TAT, ADH1A, ADH4

Biological processes related to Alcoholic Liver Cirrhosis according to GeneCards/GeneDecks:

(show all 9)
idNameGO IDScoreTop Affiliating Genes
1alcohol metabolic processGO:00606610.4ADH1A, ALDH2, ADH4
2retinol metabolic processGO:04257210.4ADH7, ADH4
3ethanol catabolic processGO:00606810.4ALDH2, ADH7
4drug metabolic processGO:01714410.3CYP2E1, CYP2A6, ADH1A
5ethanol oxidationGO:00606910.3ADH7, ADH1A, ADH4, ADH1C, ADH1B, ALDH2
6cellular aldehyde metabolic processGO:00608110.2ADH4, AKR1A1
7xenobiotic metabolic processGO:00680510.1GSTM1, ADH7, ADH1B, ADH1C, ADH4, CYP2E1
8oxidation-reduction processGO:05511410.0ADH7, PGD, CYP2E1
9small molecule metabolic processGO:0442819.8CYP2E1, GSTM1, ADH7, ADH1B, ADH1C, ADH4

Molecular functions related to Alcoholic Liver Cirrhosis according to GeneCards/GeneDecks:

(show all 7)
idNameGO IDScoreTop Affiliating Genes
1alcohol dehydrogenase activity, zinc-dependentGO:00402410.4ADH4, ADH1A, ADH1B, ADH7
2retinol dehydrogenase activityGO:00474510.4ADH4, ADH7
3alditol:NADP+ 1-oxidoreductase activityGO:00403210.3AKR1A1, ADH4
4alcohol dehydrogenase (NAD) activityGO:00402210.3ADH7, ADH1A, ADH4, ADH1C
5electron carrier activityGO:00905510.3AKR1A1, CYP2E1, CYP2A6, ALDH2
6oxidoreductase activity, acting on paired donors, with incorporation or reduction of molecular oxygen, reduced flavin or flavoprGO:01671210.3CYP2E1, CYP2A6
7retinol bindingGO:01984110.1ADH7, ADH4

Products for genes affiliated with Alcoholic Liver Cirrhosis

  • Antibodies
  • Proteins
  • Lysates
  • Antibodies

Sources for Alcoholic Liver Cirrhosis

3CDC
13ExPASy
14FMA
22GTR
23HGMD
24HMDB
25ICD10
26ICD10 via Orphanet
27ICD9CM
29IUPHAR
30KEGG
35MeSH
36MESH via Orphanet
37MGI
40NCIt
41NDF-RT
44NINDS
45Novoseek
47OMIM
48OMIM via Orphanet
51PubMed
52QIAGEN
58SNOMED-CT via Orphanet
61UMLS
62UMLS via Orphanet