MCID: ALC009
MIFTS: 43

Alcoholic Liver Cirrhosis malady

Gastrointestinal diseases, Liver diseases categories

Aliases & Classifications for Alcoholic Liver Cirrhosis

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Alcoholic Liver Cirrhosis, Aliases & Descriptions:

Name: Alcoholic Liver Cirrhosis 30 9 11
Portal Cirrhosis 9 43 60
Alcoholic Cirrhosis 9 43
Laennec's Cirrhosis, Alcoholic 9
 
Alcoholic Cirrhosis of Liver 9
Portal Cirrhosis Unspecified 9
Liver Cirrhosis, Alcoholic 60
Laennec's Cirrhosis 9


Classifications:

Malacards categories (disease lists): (See all malacards categories)
Anatomical: Gastrointestinal diseases, Liver diseases


External Ids:

Disease Ontology9 DOID:14018
NCIt38 C34782
ICD9CM27 571.2
MeSH33 D008104
ICD1025 K70.3

Summaries for Alcoholic Liver Cirrhosis

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MalaCards based summary: Alcoholic Liver Cirrhosis, also known as portal cirrhosis, is related to liver cirrhosis and hepatitis. An important gene associated with Alcoholic Liver Cirrhosis is ADH4 (alcohol dehydrogenase 4 (class II), pi polypeptide), and among its related pathways are Vitamin A and carotenoid metabolism and Abacavir Pathway, Pharmacokinetics/Pharmacodynamics. The compounds p-nitroanisole and nitrosamine have been mentioned in the context of this disorder. Affiliated tissues include liver, bone and bone marrow.

Related Diseases for Alcoholic Liver Cirrhosis

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Diseases related to Alcoholic Liver Cirrhosis via text searches within MalaCards or GeneCards Suite gene sharing:

(show top 50)    (show all 95)
idRelated DiseaseScoreTop Affiliating Genes
1liver cirrhosis31.4ADH1B, ADH1C, ALDH2, CYP2A6, CYP2E1
2hepatitis30.7AHSG, CYP2E1, NAT2, CYP2A6
3alcohol dependence30.7ADH1B, ADH1C
4pancreatitis30.6ALDH2, ADH1B, ADH1C, CYP2E1
5viral hepatitis30.4ADH1B, CYP2A6
6alcohol abuse30.3ADH1C, CYP2E1, ALDH2
7liver disease30.2ADH1B, ADH4, CYP2E1, ALDH2
8fatty liver disease29.9AHSG, CYP2E1, ALDH2, CYP2A6
9hepatocellular carcinoma29.5CYP2A6, CYP2E1, AHSG, NAT2, ADH1B, ALDH2
10hepatitis c10.5
11peritonitis10.5
12hepatitis c virus10.5
13esophagitis10.5
14hepatorenal syndrome10.4
15fetal alcohol syndrome10.4ADH1B
16calciphylaxis10.3
17budd-chiari syndrome10.3
18bacteremia10.3
19alcoholic hepatitis10.3
20hepatitis b10.3
21blindness10.3
22hepatic coma10.2
23megaloblastic anemia10.2
24hepatic encephalopathy10.2
25insulin-like growth factor i10.2
26hemochromatosis10.2
27multiple myeloma10.2
28primary biliary cirrhosis10.2
29portal hypertension10.2
30necrotizing fasciitis10.2
31colitis10.2
32fasciitis10.2
33gastroenteritis10.2
34meningitis10.2
35myeloma10.2
36neuropathy10.2
37periodontitis10.2
38protein-energy malnutrition10.2
39psoriasis10.2
40purpura10.2
41schistosomiasis10.2
42thyroiditis10.2
43hyperprolinemia10.2
44nonalcoholic steatohepatitis10.2
45varicose veins10.2
46tongue squamous cell carcinoma10.1ALDH2, ADH1B
47oral cancer10.1ADH1C, CYP2E1
48siderosis10.1
49hypotrichosis10.1
50acrodermatitis enteropathica10.0

Graphical network of the top 20 diseases related to Alcoholic Liver Cirrhosis:



Diseases related to alcoholic liver cirrhosis

Symptoms for Alcoholic Liver Cirrhosis

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Drugs & Therapeutics for Alcoholic Liver Cirrhosis

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Drug clinical trials:

Search ClinicalTrials for Alcoholic Liver Cirrhosis

Search NIH Clinical Center for Alcoholic Liver Cirrhosis

Genetic Tests for Alcoholic Liver Cirrhosis

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Anatomical Context for Alcoholic Liver Cirrhosis

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MalaCards organs/tissues related to Alcoholic Liver Cirrhosis:

31
Liver, Bone, Bone marrow, Small intestine, Monocytes, T cells, Thyroid, Skin, B cells

LifeMap Discovery
Data from LifeMap, the Embryonic Development and Stem Cells Database

Cells/anatomical compartments in embryo or adult related to Alcoholic Liver Cirrhosis:
id TissueAnatomical CompartmentCell Relevance
1 LiverLiver LobuleHepatocytes Affected by disease

Animal Models for Alcoholic Liver Cirrhosis or affiliated genes

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Publications for Alcoholic Liver Cirrhosis

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Articles related to Alcoholic Liver Cirrhosis:

(show top 50)    (show all 214)
idTitleAuthorsYear
1
Alcohol drinking pattern and risk of alcoholic liver cirrhosis: A prospective cohort study. (25634330)
2015
2
Aldehyde dehydrogenase 2 polymorphism influences development to hepatocellular carcinoma in East Asian alcoholic liver cirrhosis. (25778454)
2015
3
Serum amyloid A and C-reactive protein positive nodule in alcoholic liver cirrhosis, hard to make definite diagnosis. (23607539)
2013
4
Different patterns of decompensation in patients with alcoholic vs. non-alcoholic liver cirrhosis. (22530565)
2012
5
Iliopsoas muscle hematoma secondary to alcoholic liver cirrhosis. (23185153)
2012
6
Induction of blood lymphocyte cytochrome P450 2E1 in early stage alcoholic liver cirrhosis. (20843640)
2011
7
Potential therapeutic application of intravenous autologous bone marrow infusion in patients with alcoholic liver cirrhosis. (21417817)
2011
8
Systemic and hepatic vein galectin-3 are increased in patients with alcoholic liver cirrhosis and negatively correlate with liver function. (21715185)
2011
9
Endotoxin and tumor necrosis factor-receptor levels in portal and hepatic vein of patients with alcoholic liver cirrhosis receiving elective transjugular intrahepatic portosystemic shunt. (21971377)
2011
10
Pathogenesis and management of alcoholic liver cirrhosis: a review. (24367215)
2011
11
Clinical course of alcoholic liver cirrhosis: a Danish population-based cohort study. (20186844)
2010
12
Alcohol abstinence and orthotopic liver transplantation in alcoholic liver cirrhosis. (19460531)
2009
13
Do common genetic variants in endotoxin signaling pathway contribute to predisposition to alcoholic liver cirrhosis? (19278365)
2009
14
A functional polymorphism of the NFKB1 gene increases the risk for alcoholic liver cirrhosis in patients with alcohol dependence. (19673747)
2009
15
Alcohol dehydrogenase and aldehyde dehydrogenase gene polymorphism in alcohol liver cirrhosis and alcohol chronic pancreatitis among Polish individuals. (17454860)
2007
16
Evaluation of quantitative portal venous, hepatic arterial, and total hepatic tissue blood flow using xenon CT in alcoholic liver cirrhosis: comparison with liver cirrhosis C. (17331165)
2007
17
Clinical challenges and images in GI. Image 2. Perforative peritonitis on sclerosing encapsulating peritonitis (abdominal cocoon) in a patient with alcoholic liver cirrhosis. (17383416)
2007
18
Auxiliary partial orthotopic living donor liver transplantation in a patient with alcoholic liver cirrhosis to overcome donor steatosis. (16623878)
2006
19
Osteoprotegerin and RANKL in alcoholic liver cirrhosis. (15780054)
2005
20
Unique hypervascular nodules in alcoholic liver cirrhosis: identical to focal nodular hyperplasia-like nodules? (15582133)
2004
21
Erythropoietin increases platelet reactivity and platelet counts in patients with alcoholic liver cirrhosis: a randomized, double-blind, placebo-controlled study. (15298638)
2004
22
Spontaneous regurgitation of portal blood flow normalized by meal intake in a patient with alcoholic liver cirrhosis. (12644050)
2003
23
Polymorphisms in the DNA repair gene XRCC1 and susceptibility to alcoholic liver cirrhosis in older Southeastern Brazilians. (12175549)
2002
24
Indication of liver transplantation in severe alcoholic liver cirrhosis: quantitative evaluation and optimal timing. (11804670)
2002
25
Impaired accommodation of proximal stomach in patients with alcoholic liver cirrhosis. (12523589)
2002
26
Mechanisms of endotoxin tolerance in patients with alcoholic liver cirrhosis: role of interleukin 10, interleukin 1 receptor antagonist, and soluble tumour necrosis factor receptors as well as effector cell desensitisation. (10896923)
2000
27
N-acetyltransferase-2, glutathione S-transferase M1, alcohol dehydrogenase, and cytochrome P450IIE1 genotypes in alcoholic liver cirrhosis: a case-control study. (10232877)
1999
28
Influence of liver failure, ascites, and energy expenditure on the response to oral nutrition in alcoholic liver cirrhosis. (9263252)
1997
29
Serum and ascitic levels of soluble intercellular adhesion molecule-1 in patients with alcoholic liver cirrhosis: relation to biochemical markers of disease activity and alcohol intake. (8865970)
1996
30
Survival in alcoholic liver cirrhosis: prognostic value of portal pressure, size of esophageal varices and biochemical data. Comparison with Child classification. (8776835)
1996
31
Aeromonas sobria infection with severe muscle degeneration in a patient with alcoholic liver cirrhosis. (8540527)
1995
32
Impaired secretion and mRNA expression of monokines by alveolar macrophages from nonsmoking patients with alcoholic liver cirrhosis. (7876633)
1995
33
Thallium-201 per rectal scintigraphy improves prognostic evaluation in alcoholic liver cirrhosis of low and mid severity. (7661170)
1995
34
Spontaneous bacterial peritonitis and culture negative neutrocytic ascites in patients with non-alcoholic liver cirrhosis. (7827291)
1994
35
Reduced concentration of hepatic alpha-tocopherol in patients with alcoholic liver cirrhosis. (1580927)
1992
36
The concentration of thiamin and thiamin phosphate esters in patients with alcoholic liver cirrhosis. (1476555)
1992
37
Mechanism of feminization in male patients with non-alcoholic liver cirrhosis: role of sex hormone-binding globulin. (1916151)
1991
38
Insulin-like growth factor I: a good indicator of functional hepatocellular capacity in alcoholic liver cirrhosis. (1865082)
1991
39
L-alanine plasma levels after oral loads in non-alcoholic liver cirrhosis: relationship with urea extraformation and ammoniogenesis. (1742521)
1991
40
Increased levels of fibrinolysis reaction products (D-dimer) in patients with decompensated alcoholic liver cirrhosis. (1754853)
1991
41
Morphologic changes of small intestine epithelium in the course of post-alcoholic liver cirrhosis. (2347293)
1990
42
Studies on the monocyte interleukin-1 and tumour necrosis factor-alpha production in patients with alcoholic liver cirrhosis. (2636361)
1989
43
High interleukin-6 serum levels and increased production by leucocytes in alcoholic liver cirrhosis. Correlation with IgA serum levels and lymphokines production. (2505958)
1989
44
Bone changes in alcoholic liver cirrhosis. A histomorphometrical analysis of 52 cases. (3044713)
1988
45
Impaired early insulin response to intravenous glucose in alcoholic liver cirrhosis. (3296134)
1987
46
Pneumococcal vaccination: the response of patients with alcoholic liver cirrhosis. (6479858)
1984
47
Cholecystokinin-stimulated and postprandial serum concentrations of bile acids in alcoholic liver cirrhosis. (6474087)
1984
48
T-cell subsets in peripheral blood and ascitic fluid of patients with alcoholic liver cirrhosis. (6136678)
1983
49
Reticuloendothelial function in patients with alcoholic liver cirrhosis. (7323686)
1981
50
Autoantibodies, histocompatibility antigens and testosterone in males with alcoholic liver cirrhosis. (6973433)
1981

Variations for Alcoholic Liver Cirrhosis

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Expression for genes affiliated with Alcoholic Liver Cirrhosis

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Search GEO for disease gene expression data for Alcoholic Liver Cirrhosis.

Pathways for genes affiliated with Alcoholic Liver Cirrhosis

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Pathways related to Alcoholic Liver Cirrhosis according to GeneCards Suite gene sharing:

(show all 21)
idSuper pathways (with members indented)ScoreTop Affiliating Genes
1
Show member pathways
9.7CYP2E1, ADH4
29.6ADH1C, ADH1B
39.5CYP2E1, CYP2A6
49.5CYP2A6, CYP2E1
59.5CYP2E1, CYP2A6
6
Show member pathways
9.4CYP2E1, ALDH2
7
Show member pathways
bupropion degradation36
methylglyoxal degradation III36
nicotine degradation III36
nicotine degradation IV36
9.1CYP2A6, ADH1B, CYP2E1
8
Show member pathways
acetate conversion to acetyl-CoA36
oxidative ethanol degradation III36
ethanol degradation IV36
9.0ALDH2, ADH1B, CYP2E1
9
Show member pathways
Retinol metabolism58
8.9CYP2A6, CYP2E1, ALDH2
10
Show member pathways
tryptophan degradation X (mammalian, via tryptamine)36
2-amino-3-carboxymuconate semialdehyde degradation to glutaryl-CoA36
tryptophan degradation36
glutaryl-CoA degradation36
serotonin degradation36
NAD de novo biosynthesis36
superpathway of melatonin degradation36
tryptophan degradation to 2-amino-3-carboxymuconate semialdehyde36
tryptophan utilization I36
melatonin degradation I36
8.9CYP2A6, ADH1B, ALDH2
118.7CYP2A6, NAT2, CYP2E1
12
Show member pathways
8.7NAT2, CYP2A6, CYP2E1
13
Show member pathways
8.7ADH4, ADH1B, ADH1C, ALDH2
14
Show member pathways
phenylalanine utilization36
noradrenaline and adrenaline degradation36
phenylalanine degradation IV36
8.7ADH4, ALDH2, ADH1B, ADH1C
15
Show member pathways
glycolysis36
gluconeogenesis36
Glycolysis and Gluconeogenesis36
8.7ADH1B, ALDH2, ADH1C, ADH4
16
Show member pathways
mitochondrial L-carnitine shuttle pathway36
Saturated fatty acid biosynthesis58
8.7ADH1C, ADH4, ADH1B, ALDH2
17
Show member pathways
8.5NAT2, ALDH2, CYP2A6
18
Show member pathways
7.7ADH4, ALDH2, ADH1B, CYP2A6, CYP2E1, ADH1C
19
Show member pathways
7.5ADH1C, CYP2A6, ADH4, ADH1B, CYP2E1, NAT2
20
Show member pathways
6.9CYP2A6, ADH1B, ADH4, ADH1C, NAT2, CYP2E1
21
Show member pathways
6.9ADH1C, CYP2A6, ALDH2, ADH1B, ADH4, CYP2E1

Compounds for genes affiliated with Alcoholic Liver Cirrhosis

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Compounds related to Alcoholic Liver Cirrhosis according to GeneCards Suite gene sharing:

(show top 50)    (show all 173)
idCompoundScoreTop Affiliating Genes
1p-nitroanisole439.9CYP2A6, CYP2E1
2nitrosamine439.9CYP2E1, CYP2A6
3ndpa439.9CYP2A6, CYP2E1
4n-nitrosomethylbenzylamine439.9CYP2E1, CYP2A6
5diallylsulfide439.9CYP2E1, CYP2A6
61,3-dimethyluric acid439.9CYP2E1, CYP2A6
73-methylxanthine439.8CYP2A6, CYP2E1
84-methylpyrazole439.7CYP2A6, CYP2E1
91-aminobenzotriazole439.7CYP2A6, CYP2E1
10chloralhydrate439.6CYP2E1, ALDH2
11pyrazole43 1210.6ADH1C, CYP2E1, CYP2A6
12nitrosamines439.5CYP2E1, CYP2A6
13tienilic acid439.5CYP2E1, CYP2A6
14Aniline24 1210.5CYP2E1, NAT2
15betaine aldehyde43 2410.5ADH1B, ADH1C, ALDH2
163a,7a-Dihydroxy-5b-cholestan-26-al249.5ADH1C, ADH1B, ALDH2
171,7-dimethyluric acid43 2410.4NAT2, CYP2A6
181-methyluric acid43 2410.4NAT2, CYP2A6
193,4-Dihydroxyphenylglycol249.3ADH1C, ADH1B
20afmu439.3NAT2, CYP2A6
21disulfiram43 49 59 1212.3CYP2A6, ALDH2, CYP2E1
22mspi439.2CYP2E1, ADH1B, NAT2
231-methylxanthine43 2410.2CYP2A6, CYP2E1, NAT2
24dimethylnitrosamine439.2NAT2, CYP2E1, CYP2A6
25mephenytoin43 49 1211.2NAT2, CYP2E1, CYP2A6
26debrisoquine43 4910.1CYP2E1, NAT2, CYP2A6
27paraoxon43 2410.1NAT2, CYP2A6, CYP2E1
28isoniazid43 49 1211.1CYP2E1, CYP2A6, NAT2
29chlorzoxazone43 28 1211.1NAT2, CYP2E1, CYP2A6
30paraxanthine43 2410.1NAT2, CYP2E1, CYP2A6
31rifampin49 1210.1CYP2A6, NAT2, CYP2E1
32tolbutamide43 28 49 1212.1CYP2E1, CYP2A6, NAT2
33midazolam43 49 1211.1CYP2E1, CYP2A6, NAT2
34epoxide439.1CYP2A6, NAT2, CYP2E1
35nad28 2410.0ALDH2, ADH1C, ADH1B, ADH4
36rifampicin43 28 5911.0CYP2A6, CYP2E1, NAT2
37gsts439.0NAT2, CYP2E1, ALDH2
38nadh43 24 1211.0ADH1B, ALDH2, ADH1C, ADH4
39formaldehyde43 2410.0CYP2E1, ALDH2, ADH1C, CYP2A6
40betacarotene438.9CYP2E1, ALDH2, NAT2
41acetaminophen43 2 49 24 1212.8NAT2, CYP2E1, CYP2A6
42cyclophosphamide43 49 1210.8ADH1C, NAT2, CYP2E1, CYP2A6
43acetaldehyde28 43 2410.5CYP2E1, ADH1C, ADH1B, ALDH2, CYP2A6
44NADP248.5ADH1B, ALDH2, CYP2A6, ADH1C, CYP2E1
45nadph43 249.5ALDH2, ADH1B, CYP2E1, CYP2A6, ADH1C
46Water248.4ALDH2, CYP2A6, CYP2E1, ADH1B, ADH1C
47dopamine43 28 24 1211.4ALDH2, ADH1B, CYP2E1, CYP2A6
48rsai438.2ALDH2, ADH1B, ADH1C, NAT2, CYP2E1
49ethanol43 49 24 1211.2ADH1B, ADH1C, AHSG, CYP2E1, ADH4, ALDH2
50vitamin a43 24 129.9CYP2E1, NAT2, ADH1C, ADH4, ADH1B, ALDH2

GO Terms for genes affiliated with Alcoholic Liver Cirrhosis

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Biological processes related to Alcoholic Liver Cirrhosis according to GeneCards Suite gene sharing:

idNameGO IDScoreTop Affiliating Genes
1steroid metabolic processGO:00082029.5CYP2E1, CYP2A6
2alcohol metabolic processGO:00060669.4ALDH2, ADH4
3drug metabolic processGO:00171449.2CYP2E1, CYP2A6
4ethanol oxidationGO:00060698.7ADH1C, ADH4, ADH1B, ALDH2
5xenobiotic metabolic processGO:00068057.0ALDH2, ADH1B, ADH4, ADH1C, NAT2, CYP2E1
6small molecule metabolic processGO:00442816.9CYP2A6, CYP2E1, NAT2, ADH1C, ADH4, ADH1B

Molecular functions related to Alcoholic Liver Cirrhosis according to GeneCards Suite gene sharing:

idNameGO IDScoreTop Affiliating Genes
1alcohol dehydrogenase activity, zinc-dependentGO:00040249.6ADH1B, ADH4
2oxidoreductase activity, acting on paired donors, with incorporation or reduction of molecular oxygen, reduced flavin or flavoprotein as one donor, and incorporation of one atom of oxygenGO:00167129.5CYP2E1, CYP2A6
3alcohol dehydrogenase (NAD) activityGO:00040229.5ADH4, ADH1C

Products for genes affiliated with Alcoholic Liver Cirrhosis

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Sources for Alcoholic Liver Cirrhosis

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3CDC
13ExPASy
14FMA
22GTR
23HGMD
24HMDB
25ICD10
26ICD10 via Orphanet
27ICD9CM
28IUPHAR
29KEGG
33MeSH
34MESH via Orphanet
35MGI
38NCIt
39NDF-RT
42NINDS
43Novoseek
45OMIM
46OMIM via Orphanet
50PubMed
51QIAGEN
56SNOMED-CT via Orphanet
60UMLS
61UMLS via Orphanet