MCID: ALC009
MIFTS: 53

Alcoholic Liver Cirrhosis

Categories: Gastrointestinal diseases, Liver diseases

Aliases & Classifications for Alcoholic Liver Cirrhosis

MalaCards integrated aliases for Alcoholic Liver Cirrhosis:

Name: Alcoholic Liver Cirrhosis 37 12 72 14
Portal Cirrhosis 12 51 69
Liver Cirrhosis, Alcoholic 41 69
Alcoholic Cirrhosis 12 51
Laennec's Cirrhosis, Alcoholic 12
Alcoholic Cirrhosis of Liver 12
Laennec's Cirrhosis 12

Classifications:



External Ids:

Disease Ontology 12 DOID:14018
ICD10 32 K70.3
ICD9CM 34 571.2
MeSH 41 D008104
NCIt 46 C34782

Summaries for Alcoholic Liver Cirrhosis

MalaCards based summary : Alcoholic Liver Cirrhosis, also known as portal cirrhosis, is related to antipyrine metabolism and liver cirrhosis, and has symptoms including icterus An important gene associated with Alcoholic Liver Cirrhosis is ADH1B (Alcohol Dehydrogenase 1B (Class I), Beta Polypeptide), and among its related pathways/superpathways are Metabolism and Cytochrome P450 - arranged by substrate type. The drugs Angiotensin II and Losartan have been mentioned in the context of this disorder. Affiliated tissues include Liver, liver and skin, and related phenotype is homeostasis/metabolism.

Wikipedia : 72 Cirrhosis is a condition in which the liver does not function properly due to long-term damage. This... more...

Related Diseases for Alcoholic Liver Cirrhosis

Diseases related to Alcoholic Liver Cirrhosis via text searches within MalaCards or GeneCards Suite gene sharing:

(show top 50) (show all 132)
# Related Disease Score Top Affiliating Genes
1 antipyrine metabolism 30.3 ALB F2
2 liver cirrhosis 30.2 ADH1B ALB ALDH2 CYP2E1 F2 SLC17A5
3 portal hypertension 30.2 ALB F2 TNF
4 peritonitis 30.1 ALB CXCL8 F2 TNF
5 protein-energy malnutrition 29.9 ALB TF TNF
6 schistosomiasis 29.9 ALB F2 TNF
7 gastroenteritis 29.9 ALB CXCL8 TNF
8 meningitis 29.8 ALB CXCL8 TNF
9 alcohol abuse 29.6 ALDH2 CYP2E1 SLC17A5 TF
10 hepatitis b 29.6 ALB F2 SLC17A5 TNF
11 esophageal cancer 29.3 ALB ALDH2 CXCL8 GSTM1 TNF
12 hepatic encephalopathy 29.3 ALB F2 SLC17A5 TNF
13 viral hepatitis 29.3 ALB F2 SLC17A5 TNF
14 fatty liver disease 29.2 CYP2E1 PNPLA3 SLC17A5 TNF
15 nonalcoholic steatohepatitis 29.1 F2 PNPLA3 SLC17A5 TNF
16 alcoholic hepatitis 28.8 ALB CXCL8 CYP2E1 F2 SLC17A5 TNF
17 alcohol dependence 28.6 ADH1B ADH1C ADH4 ALDH2 CYP2E1 SLC17A5
18 liver disease 28.3 ALB CYP2E1 F2 PNPLA3 SLC17A5 TF
19 isoniazid toxicity 10.5 CYP2E1 NAT2
20 alcohol use disorder 10.5 ADH1B ALDH2
21 non-a-e hepatitis 10.4 ALB F2
22 alcoholic pancreatitis 10.4 ADH1B ALDH2 CYP2E1
23 hepatitis 10.4
24 methanol poisoning 10.4 ADH1B ADH1C CYP2E1
25 sister chromatid exchange, frequency of 10.4 ALDH2 CYP2E1 GSTM1
26 marburg hemorrhagic fever 10.4 F2 TNF
27 fournier gangrene 10.4 ALB F2
28 burns 10.4 ALB TNF
29 drug-induced hepatitis 10.3 CYP2E1 GSTM1 NAT2
30 pancreatitis, hereditary 10.3 ADH1B ADH1C ALDH2
31 abdominal tuberculosis 10.3 ALB F2
32 tungiasis 10.3 CXCL8 TNF
33 scabies 10.3 CXCL8 GSTM1
34 streptococcal toxic-shock syndrome 10.3 CXCL8 TNF
35 aspartylglucosaminuria 10.3 ADH1B ADH1C
36 hepatic tuberculosis 10.3 ALB F2
37 marasmus 10.3 ALB TF
38 pyuria 10.3 ALB CXCL8
39 melancholia 10.2 TF TNF
40 hepatitis e 10.2 ALB F2 TNF
41 hepatitis a 10.2 ALB F2 TNF
42 yellow nail syndrome 10.2 ALB TF
43 orbital cyst 10.2 F2 TF
44 cholangitis 10.2 ALB F2 TNF
45 pneumoconiosis 10.2 CXCL8 GSTM1 TNF
46 eclampsia 10.2 ALB F2 TNF
47 arteries, anomalies of 10.2 ALB F2 TNF
48 tuberculous meningitis 10.2 CXCL8 NAT2 TNF
49 end stage renal failure 10.2 ALB TF TNF
50 pyelonephritis 10.2 ALB CXCL8 TNF

Comorbidity relations with Alcoholic Liver Cirrhosis via Phenotypic Disease Network (PDN): (show all 26)


Acquired Thrombocytopenia Active Peptic Ulcer Disease
Acute Cystitis Acute Kidney Failure
Acute Pancreatitis Alcohol Abuse
Alcoholic Cardiomyopathy Alcoholic Gastritis
Alcoholic Hepatitis Alcoholic Neuropathy
Chronic Congestive Splenomegaly Chronic Kidney Failure
Deficiency Anemia Esophageal Varix
Familial Atrial Fibrillation Fatty Liver Disease
Heart Disease Hepatic Encephalopathy
Hepatocellular Carcinoma Hepatorenal Syndrome
Hypersplenism Iron Deficiency Anemia
Portal Hypertension Protein-Energy Malnutrition
Respiratory Failure Urea Cycle Disorder

Graphical network of the top 20 diseases related to Alcoholic Liver Cirrhosis:



Diseases related to Alcoholic Liver Cirrhosis

Symptoms & Phenotypes for Alcoholic Liver Cirrhosis

UMLS symptoms related to Alcoholic Liver Cirrhosis:


icterus

MGI Mouse Phenotypes related to Alcoholic Liver Cirrhosis:

43
# Description MGI Source Accession Score Top Affiliating Genes
1 homeostasis/metabolism MP:0005376 9.36 ADH1C AHSG ALB ALDH2 CYP2E1 F2

Drugs & Therapeutics for Alcoholic Liver Cirrhosis

Drugs for Alcoholic Liver Cirrhosis (from DrugBank, HMDB, Dgidb, PharmGKB, IUPHAR, NovoSeek, BitterDB):

(show top 50) (show all 97)
# Name Status Phase Clinical Trials Cas Number PubChem Id
1
Angiotensin II Approved, Investigational Phase 4 68521-88-0, 4474-91-3, 11128-99-7 172198 65143
2
Losartan Approved Phase 4 114798-26-4 3961
3
Propranolol Approved, Investigational Phase 4 525-66-6 4946
4
Spironolactone Approved Phase 4 1952-01-7, 52-01-7 5833
5 Angiotensin II Type 1 Receptor Blockers Phase 4
6 Angiotensin Receptor Antagonists Phase 4
7 Angiotensinogen Phase 4
8 Anti-Arrhythmia Agents Phase 4
9 Antihypertensive Agents Phase 4
10 Liver Extracts Phase 4,Phase 3,Phase 2
11 Hormone Antagonists Phase 4,Phase 2
12 Hormones Phase 4,Phase 2
13 Hormones, Hormone Substitutes, and Hormone Antagonists Phase 4,Phase 2
14 Adrenergic Agents Phase 4
15 Adrenergic Antagonists Phase 4
16 Adrenergic beta-Antagonists Phase 4
17 diuretics Phase 4
18 Diuretics, Potassium Sparing Phase 4
19 Mineralocorticoid Receptor Antagonists Phase 4
20 Mineralocorticoids Phase 4
21 Natriuretic Agents Phase 4
22 Neurotransmitter Agents Phase 4
23 Vasodilator Agents Phase 4
24
Baclofen Approved Phase 3 1134-47-0 2284
25
Ethanol Approved Phase 3 64-17-5 702
26
Everolimus Approved Phase 3 159351-69-6 6442177
27
Miconazole Approved, Investigational, Vet_approved Phase 3 22916-47-8 4189
28
Sirolimus Approved, Investigational Phase 3 53123-88-9 46835353 6436030 5284616
29
Tacrolimus Approved, Investigational Phase 3 104987-11-3 445643 439492
30
Naltrexone Approved, Investigational, Vet_approved Phase 3 16590-41-3 5360515
31
Benzocaine Approved, Investigational Phase 3 1994-09-7, 94-09-7 2337
32
Iron Approved Phase 3 7439-89-6 23925
33 tannic acid Approved, Nutraceutical Phase 3
34 Anti-Bacterial Agents Phase 3,Phase 2,Early Phase 1
35 Anti-Infective Agents Phase 3,Phase 2,Phase 1,Early Phase 1
36 Anti-Infective Agents, Local Phase 3
37 Central Nervous System Depressants Phase 3
38 Antibiotics, Antitubercular Phase 3
39 Antifungal Agents Phase 3
40 Calcineurin Inhibitors Phase 3
41 Immunosuppressive Agents Phase 3
42
Cobalt Phase 3 7440-48-4 104729
43
nalmefene Phase 3 55096-26-9 5284594
44 Narcotic Antagonists Phase 3
45 Narcotics Phase 3
46 Peripheral Nervous System Agents Phase 3
47
Prednisone Approved, Vet_approved Phase 2 53-03-2 5865
48
Rifaximin Approved, Investigational Phase 2 80621-81-4 6436173
49
Caffeine Approved, Nutraceutical Phase 2 58-08-2 2519
50 Anti-Inflammatory Agents Phase 2

Interventional clinical trials:

(show all 34)

# Name Status NCT ID Phase Drugs
1 Prevention of Decompensation in Liver Cirrhosis Unknown status NCT00239096 Phase 4 losartan (drug)
2 Hemodynamic Effects of Chronic Administration of Spironolactone and/or Propranolol in Alcoholic Cirrhotic Patients Terminated NCT00188045 Phase 4 Propranolol - Spironolactone
3 Baclofen in the Treatment of Alcohol Dependence With or Without Alcoholic Liver Disease Completed NCT01711125 Phase 3 Baclofen 30mg/day;Baclofen 75mg/day;Placebo
4 REnal Function in Liver Transplantation: Everolimus With Calcineurin Inhibitor (CNI)-Sparing sTrategy Recruiting NCT02115113 Phase 3 Everolimus;Everolimus;Tacrolimus
5 Proton Radiotherapy Versus Radiofrequency Ablation for Patients With Medium or Large Hepatocellular Carcinoma Recruiting NCT02640924 Phase 3
6 Nalmefene in Patients With Alcoholic Compensated Cirrhosis for the Treatment of Alcohol Dependence. Not yet recruiting NCT02824354 Phase 3 Nalmefene (Selincro®) 18 mg tablet;placebo
7 Phlebotomy and Risk of Hepatocellular Carcinoma in Patients With Compensated Alcoholic Cirrhosis Terminated NCT01342705 Phase 3
8 The Effectiveness and Safety for Mesenchymal Stem Cell for Alcoholic Liver Cirrhosis Unknown status NCT01741090 Phase 2
9 REVIVE(Randomized Exploratory Clinical Trial to Evaluate the Safety and Effectiveness of Stem Cell Product in Alcoholic Liver Cirrhosis Patient) Completed NCT01875081 Phase 2
10 Dose Finding Study to Assess Safety and Efficacy of Stem Cells in Liver Cirrhosis Completed NCT01591200 Phase 2
11 A Phase II, Double-blinded, Randomized, Controlled Study to Evaluate the Efficacy and Safety of Vitalliver in Patients With Decompensated Cirrhosis Completed NCT00562783 Phase 2 Vitaliver;Placebo
12 Long-term Follow-up Study of Livercellgram in Alcoholic Liver Cirrhosis Patients Who Completed Livercellgram Phase 2 Study Enrolling by invitation NCT02806011 Phase 2
13 Effects of Rifaximin in Patients With Acute Alcoholic Hepatitis Enrolling by invitation NCT02116556 Phase 2 Prednisone;Rifaximin
14 Pharmacokinetics (PK) of Tipranavir/Ritonavir, Ribavirin, Pegylated Interferon (Peg INF) in Hepatitis C (HCV) Subjects With Mild Hepatic Impairment and in HCV, Hepatitis B (HBV), Hepatitis D Infected Subjects or Alcoholic Cirrhosis With Moderate Hepatic I Completed NCT02259855 Phase 1 Tipranavir;Ritonavir;Pegylated interferon;Ribavirin
15 Pangenomic Study During Alcoholic Cirrhosis Unknown status NCT01065233
16 Measurement of Fibrinogen in Patients With Systemic Inflammatory Response Syndrome (SIRS), Sepsis or Chronicle Liver Disease on Intensive Care Units (ICU) Unknown status NCT01169168
17 Prospective Analysis Of Cardiac Function In Cirrhotic Patients By Echocardiography And Its Correlation With Events Unknown status NCT01433848
18 Indocyanine Green and Portal Pressure in Viral and Alcoholic Cirrhotic Patients With Hepatocarcinoma Unknown status NCT00827723
19 FGL2/Fibroleukin and Hepatitis C Virus Recurrence Post Liver Transplantation Unknown status NCT00701272
20 Liver Transplantation Versus Alternative Therapies for Patients With Pugh B Alcoholic Cirrhosis Completed NCT00701792
21 Adipose Tissue Involvement in Alcohol-induced Liver Inflammation in Human Completed NCT00388323
22 Randomised Open-label Multicenter Study Evaluating Ciprofloxacin in Severe Alcoholic Hepatitis Completed NCT02326103 Early Phase 1 Ciprofloxacin;Placebo
23 Influence of Probiotics on Infections in Cirrhosis Completed NCT01607528
24 Biomarkers for the Prognosis of Decompensated Alcoholic Liver Disease Completed NCT01701687
25 Acoustic Liver Biopsy in Normals and in Patients With Cirrhosis Using Endoscopic Ultrasound Completed NCT01208311
26 Subclinical Myocardial Dysfunction in Patients With Hepatic Cirrhosis Completed NCT01713478
27 Safety and Performance Trial of DIALIVE Liver Dialysis Device in Acute On Chronic Liver Failure Patients Recruiting NCT03065699
28 Comparison of ALD, NASH, and Healthy Control Patients Recruiting NCT03224949
29 Boramae Hospital Liver Cirrhosis Patient Cohort Study Recruiting NCT01943318
30 National Cohort of Uncomplicated Alcoholic Cirrhosis Active, not recruiting NCT01213927
31 Zinc Supplementation in Alcoholic Cirrhosis Active, not recruiting NCT02072746
32 Validation of the Procedure of Early Liver Transplantation in Alcoholic Hepatitis Resisting to Medical Treatment Active, not recruiting NCT01756794
33 Prevalence of Exocrine Pancreatic Insufficiency in Patients With Decompensated Cirrhosis Not yet recruiting NCT03236038
34 Influence of ABO Blood Group on the Risk of Complications in Alcoholic or Viral C Cirrhosis? Not yet recruiting NCT03342170

Search NIH Clinical Center for Alcoholic Liver Cirrhosis

Cell-based therapeutics:


LifeMap Discovery
Data from LifeMap, the Embryonic Development and Stem Cells Database
Read about Alcoholic Liver Cirrhosis cell therapies at LifeMap Discovery.
Stem-cell-based therapeutic approaches for Alcoholic Liver Cirrhosis:
Livercellgram, bone marrow-derived mesenchymal stem cells for treatment of alcoholic liver cirrhosis
Embryonic/Adult Cultured Cells Related to Alcoholic Liver Cirrhosis:
Bone marrow-derived mesenchymal stem cells

Cochrane evidence based reviews: liver cirrhosis, alcoholic

Genetic Tests for Alcoholic Liver Cirrhosis

Anatomical Context for Alcoholic Liver Cirrhosis

MalaCards organs/tissues related to Alcoholic Liver Cirrhosis:

38
Liver, Skin, Bone, Monocytes, Bone Marrow, T Cells, Small Intestine
LifeMap Discovery
Data from LifeMap, the Embryonic Development and Stem Cells Database

Cells/anatomical compartments in embryo or adult related to Alcoholic Liver Cirrhosis:
# Tissue Anatomical CompartmentCell Relevance
1 Liver Liver Lobule Hepatocytes Affected by disease

Publications for Alcoholic Liver Cirrhosis

Articles related to Alcoholic Liver Cirrhosis:

(show top 50) (show all 250)
# Title Authors Year
1
A study of serological markers and lipid profile in non-alcoholic liver cirrhosis patients. ( 29348089 )
2018
2
Reduced platelet activation and platelet aggregation in patients with alcoholic liver cirrhosis. ( 28895774 )
2017
3
Characterization of Body Composition and Definition of Sarcopenia in Patients with Alcoholic Liver Cirrhosis: a Computed Tomography Based Study. ( 28665532 )
2017
4
Diagnostic specificity and sensitivity of PIVKAII, GP3, CSTB, SCCA1 and HGF for the diagnosis of hepatocellular carcinoma in patients with alcoholic liver cirrhosis. ( 28766361 )
2017
5
Bacteremia Caused by Campylobacter Fetus in a Patient With Hepatitis B Virus Infection Complicated with Alcoholic Liver Cirrhosis. ( 28879715 )
2017
6
Relationships between serum selenium and zinc concentrations versus profibrotic and proangiogenic cytokines (FGF-19 and endoglin) in patients with alcoholic liver cirrhosis. ( 28954507 )
2017
7
Disialo-Trisialo Bridging Phenomenon of Transferrin Isoform Detected by Capillary Electrophoresis in Patient with Alcoholic Liver Cirrhosis: First Case Report from Asia. ( 28271694 )
2017
8
Association between Serum Selenium Concentrations and Levels of Proinflammatory and Profibrotic Cytokines-Interleukin-6 and Growth Differentiation Factor-15, in Patients with Alcoholic Liver Cirrhosis. ( 28430124 )
2017
9
A tip from the nose: rhinocerebral mucormycosis in a patient with alcoholic liver cirrhosis and cocaine abuse, an uncommon association. ( 28784893 )
2017
10
Cost of illness of non-alcoholic liver cirrhosis in Japan: A time trend analysis and future projections. ( 28497644 )
2017
11
Data on gut metagenomes of the patients with alcoholic dependence syndrome and alcoholic liver cirrhosis. ( 28138508 )
2017
12
A Single Nucleotide Polymorphism in the RASGRF2 Gene Is Associated with Alcoholic Liver Cirrhosis in Men. ( 27992614 )
2016
13
Length of Variable Numbers of Tandem Repeats in the Carboxyl Ester Lipase (CEL) Gene May Confer Susceptibility to Alcoholic Liver Cirrhosis but Not Alcoholic Chronic Pancreatitis. ( 27802312 )
2016
14
Letter to the editor: treatment for superficial esophageal cancer with rectal varices bleeding in a patient with alcoholic liver cirrhosis. ( 26728025 )
2016
15
Concentrations of fetuin-A, osteoprotegerin and I+-Klotho in patients with alcoholic liver cirrhosis. ( 27882180 )
2016
16
Aldehyde Dehydrogenase 2 (ALDH2) Polymorphism and the Risk of Alcoholic Liver Cirrhosis among East Asians: A Meta-Analysis. ( 27189280 )
2016
17
Lispro insulin in people with non-alcoholic liver cirrhosis and type 2 diabetes mellitus. ( 26803356 )
2016
18
Serum Concentrations of Selected Heavy Metals in Patients with Alcoholic Liver Cirrhosis from the Lublin Region in Eastern Poland. ( 27304961 )
2016
19
Henoch-SchAPnlein purpura nephritis and colitis in an adult patient with alcoholic liver cirrhosis. ( 27668165 )
2016
20
A study on hematological spectrum in patients with alcoholic liver cirrhosis. ( 27727674 )
2016
21
Behavior of Oxidative Stress Markers in Alcoholic Liver Cirrhosis Patients. ( 28074118 )
2016
22
Risk for alcoholic liver cirrhosis after an initial hospital contact with alcohol problems: A nationwide prospective cohort study. ( 27862159 )
2016
23
CLIF-SOFA score and SIRS are independent prognostic factors in patients with hepatic encephalopathy due to alcoholic liver cirrhosis. ( 27367990 )
2016
24
Confluent hepatic fibrosis in alcohol liver cirrhosis with elevated pivkaii value - usefulness of immunostaining for EZH2 and p16(INK4a) in differentiating it from cholangiolocellular carcinoma - Confluent hepatic fibrosis. ( 27418411 )
2016
25
Aldehyde dehydrogenase 2 polymorphism influences development to hepatocellular carcinoma in East Asian alcoholic liver cirrhosis. ( 25778454 )
2015
26
Flavobacterium ceti From Blood Samples of a Korean Patient With Alcoholic Liver Cirrhosis. ( 25932454 )
2015
27
Alcohol dehydrogenase 1C (ADH1C) gene polymorphism and alcoholic liver cirrhosis risk: a meta analysis. ( 26379912 )
2015
28
Genetic polymorphism in alcohol dehydrogenase 2 (ADH2) gene and alcoholic liver cirrhosis risk. ( 26221330 )
2015
29
Circulating Lipids Are Associated with Alcoholic Liver Cirrhosis and Represent Potential Biomarkers for Risk Assessment. ( 26107182 )
2015
30
A variant in the nuclear dot protein 52kDa gene increases the risk for spontaneous bacterial peritonitis in patients with alcoholic liver cirrhosis. ( 26493630 )
2015
31
Alcohol drinking pattern and risk of alcoholic liver cirrhosis: A prospective cohort study. ( 25634330 )
2015
32
Alcoholic Liver Cirrhosis and Significant Risk Factors for the Development of Alcohol-related Hepatocellular Carcinoma--Japan, 2012. ( 26946783 )
2015
33
Predictors of hepatorenal syndrome in alcoholic liver cirrhosis. ( 25820623 )
2015
34
Hypothyroidism Enhanced Portal Hypertension in a Patient with Alcoholic Liver Cirrhosis, Resulting in the Development of Ascites. ( 26370856 )
2015
35
Activity of MMP1 and MMP13 and Amino Acid Metabolism in Patients with Alcoholic Liver Cirrhosis. ( 25863779 )
2015
36
Plasma osteopontin is a biomarker for the severity of alcoholic liver cirrhosis, not for hepatocellular carcinoma screening. ( 26122937 )
2015
37
Alcohol abuse and alcoholic liver cirrhosis leading to spontaneous muscle hematoma: an event fraught with danger. ( 25969676 )
2015
38
Proinflammatory Cytokines (IL-1I+, IL-6) and Hepatocyte Growth Factor in Patients with Alcoholic Liver Cirrhosis. ( 26448742 )
2015
39
Correlation between hepatic blood flow and liver function in alcoholic liver cirrhosis. ( 25493018 )
2014
40
Interleukin 10 promoter haplotype is associated with alcoholic liver cirrhosis in Taiwanese patients. ( 24835349 )
2014
41
Septic shock due to Aeromonas hydrophila bacteremia in a patient with alcoholic liver cirrhosis: a case report. ( 25464981 )
2014
42
Evidence of degraded BMD and geometry at the proximal femora in male patients with alcoholic liver cirrhosis. ( 25172381 )
2014
43
Successful treatment of invasive gastric mucormycosis in a patient with alcoholic liver cirrhosis: A case report. ( 25009590 )
2014
44
Systematic review with meta-analysis: the I148M variant of patatin-like phospholipase domain-containing 3 gene (PNPLA3) is significantly associated with alcoholic liver cirrhosis. ( 25060292 )
2014
45
Vitamin D status, bone metabolism and bone mass in patients with alcoholic liver cirrhosis. ( 25318918 )
2014
46
Lacosamide as add-on treatment of focal symptomatic epilepsy in a patient with alcoholic liver cirrhosis. ( 25667897 )
2014
47
An unusual cause of spontaneous bacterial peritonitis due to Campylobacter fetus with alcoholic liver cirrhosis. ( 23417384 )
2013
48
Evaluation of periodontal status in alcoholic liver cirrhosis patients: a comparative study. ( 23811642 )
2013
49
Portosystemic shunt via the superior mesenteric and right ovarian vein leading to small intestine bleeding in alcoholic liver cirrhosis. ( 23513021 )
2013
50
Serum amyloid A and C-reactive protein positive nodule in alcoholic liver cirrhosis, hard to make definite diagnosis. ( 23607539 )
2013

Variations for Alcoholic Liver Cirrhosis

Expression for Alcoholic Liver Cirrhosis

Search GEO for disease gene expression data for Alcoholic Liver Cirrhosis.

Pathways for Alcoholic Liver Cirrhosis

Pathways related to Alcoholic Liver Cirrhosis according to GeneCards Suite gene sharing:

(show all 18)
# Super pathways Score Top Affiliating Genes
1
Show member pathways
13.9 ADH1B ADH1C ADH4 ALB ALDH2 CYP2A6
2
Show member pathways
12.86 ADH1B ADH1C ADH4 ALDH2 CYP2A6 CYP2E1
3
Show member pathways
12.46 ADH1B ADH1C ADH4 ALDH2
4
Show member pathways
12.02 ADH1B ALDH2 CYP2A6 CYP2E1
5
Show member pathways
11.91 ADH1B ADH1C ADH4 ALDH2 CYP2A6 CYP2E1
6
Show member pathways
11.67 ADH1B ADH1C ADH4 ALDH2
7
Show member pathways
11.6 CYP2A6 CYP2E1 GSTM1
8
Show member pathways
11.57 ADH1B ADH1C ADH4
9
Show member pathways
11.05 CYP2A6 CYP2E1 NAT2
10 10.99 CYP2A6 CYP2E1 GSTM1
11 10.86 CYP2A6 CYP2E1
12 10.83 CXCL8 TNF
13
Show member pathways
10.75 ADH1B ADH1C ADH4 ALDH2
14
Show member pathways
10.72 ADH1B ALDH2 CYP2E1
15
Show member pathways
10.67 ADH1B ADH4 ALDH2
16 10.65 ADH1B ADH1C
17
Show member pathways
10.37 ADH1B CYP2A6 CYP2E1
18 10.27 CYP2E1 GSTM1

GO Terms for Alcoholic Liver Cirrhosis

Cellular components related to Alcoholic Liver Cirrhosis according to GeneCards Suite gene sharing:

# Name GO ID Score Top Affiliating Genes
1 endoplasmic reticulum lumen GO:0005788 9.26 AHSG ALB F2 TF
2 blood microparticle GO:0072562 8.92 AHSG ALB F2 TF

Biological processes related to Alcoholic Liver Cirrhosis according to GeneCards Suite gene sharing:

# Name GO ID Score Top Affiliating Genes
1 cellular protein metabolic process GO:0044267 9.56 AHSG ALB F2 TF
2 platelet degranulation GO:0002576 9.54 AHSG ALB TF
3 oxidation-reduction process GO:0055114 9.43 ADH1B ADH1C ADH4 ALDH2 CYP2A6 CYP2E1
4 epoxygenase P450 pathway GO:0019373 9.4 CYP2A6 CYP2E1
5 embryonic digestive tract development GO:0048566 9.32 CXCL8 TNF
6 alcohol metabolic process GO:0006066 9.16 ADH4 ALDH2
7 ethanol oxidation GO:0006069 8.92 ADH1B ADH1C ADH4 ALDH2

Molecular functions related to Alcoholic Liver Cirrhosis according to GeneCards Suite gene sharing:

# Name GO ID Score Top Affiliating Genes
1 oxidoreductase activity GO:0016491 9.43 ADH1B ADH1C ADH4 ALDH2 CYP2A6 CYP2E1
2 oxidoreductase activity, acting on paired donors, with incorporation or reduction of molecular oxygen, reduced flavin or flavoprotein as one donor, and incorporation of one atom of oxygen GO:0016712 9.37 CYP2A6 CYP2E1
3 retinol dehydrogenase activity GO:0004745 9.32 ADH1C ADH4
4 arachidonic acid epoxygenase activity GO:0008392 9.26 CYP2A6 CYP2E1
5 alcohol dehydrogenase (NAD) activity GO:0004022 9.16 ADH1C ADH4
6 alcohol dehydrogenase activity, zinc-dependent GO:0004024 8.8 ADH1B ADH1C ADH4

Sources for Alcoholic Liver Cirrhosis

3 CDC
7 CNVD
9 Cosmic
10 dbSNP
11 DGIdb
16 ExPASy
18 FMA
27 GO
28 GTR
29 HGMD
30 HMDB
31 HPO
32 ICD10
33 ICD10 via Orphanet
34 ICD9CM
35 IUPHAR
36 KEGG
37 LifeMap
39 MedGen
41 MeSH
42 MESH via Orphanet
43 MGI
45 NCI
46 NCIt
47 NDF-RT
50 NINDS
51 Novoseek
53 OMIM
54 OMIM via Orphanet
58 PubMed
60 QIAGEN
65 SNOMED-CT via HPO
66 SNOMED-CT via Orphanet
67 TGDB
68 Tocris
69 UMLS
70 UMLS via Orphanet
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