MCID: ALC009
MIFTS: 55

Alcoholic Liver Cirrhosis malady

Gastrointestinal diseases, Liver diseases categories

Summaries for Alcoholic Liver Cirrhosis

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32MalaCards
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MalaCards: Alcoholic Liver Cirrhosis, also known as portal cirrhosis, is related to liver cirrhosis and hepatitis. An important gene associated with Alcoholic Liver Cirrhosis is ADH1C (alcohol dehydrogenase 1C (class I), gamma polypeptide), and among its related pathways are Doxepin Pathway, Pharmacokinetics and phenylalanine utilization. The compounds 4-Iodopyrazole and 1-methylxanthine have been mentioned in the context of this disorder. Affiliated tissues include liver, bone and bone marrow, and related mouse phenotype homeostasis/metabolism.

Aliases & Classifications for Alcoholic Liver Cirrhosis

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8Disease Ontology, 10DISEASES, 44Novoseek, 60UMLS, 56SNOMED-CT, 39NCIt, 27ICD9CM, 34MeSH, 25ICD10
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Classifications:

Malacards categories (disease lists): (See all malacards categories)
Anatomical: Gastrointestinal diseases, Liver diseases


Aliases & Descriptions:

alcoholic liver cirrhosis 8 10
portal cirrhosis 8 44 60
alcoholic cirrhosis 8 44
laennec's cirrhosis, alcoholic 8
alcoholic cirrhosis of liver 8
portal cirrhosis unspecified 8
liver cirrhosis, alcoholic 60
laennec's cirrhosis 8


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Disease Ontology8 DOID:14018
NCIt39 C34782
ICD9CM27 571.2
MeSH34 D008104
ICD1025 K70.3

Related Diseases for Alcoholic Liver Cirrhosis

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17GeneCards, 18GeneDecks
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Diseases related to Alcoholic Liver Cirrhosis via text searches within MalaCards or GeneCards/GeneDecks gene sharing:

(show top 50)    (show all 101)
idRelated DiseaseScoreTop Affiliating Genes
1liver cirrhosis31.9AKR1A1, LSL, GHRH, CYP2E1, ADH1B, ADH1C
2hepatitis31.1TAT, CYP2E1, ASGR2
3hepatitis c30.8ASGR2, LSL, CYP2E1
4pancreatitis30.8CYP2E1, ALDH2, ADH1C, ADH1B
5alcoholic pancreatitis30.8ADH1C, AKR1A1, CYP2E1, ALDH2, ADH1B
6hepatocellular carcinoma30.5ADH1B, AHSG, AKR1A1, CYP2A6, NAT2, TAT
7alcohol dependence30.4ADH1B, ADH1A, ADH4, ADH7, ALDH2
8hepatitis b30.4TAT, ALDH2, NAT2, ASGR2
9fatty liver disease30.2CYP2E1
10alcohol abuse30.2ALDH2, CYP2E1, AKR1A1, ADH1C
11viral hepatitis30.2ADH1B, CYP2A6, AKR1A1
12diabetes mellitus30.2ALDH2, NAT2, CYP2E1, AHSG, LSL
13alcoholic hepatitis10.8
14peritonitis10.5
15hepatitis a10.4
16esophagitis10.4
17liver disease10.4
18calciphylaxis10.3
19hepatorenal syndrome10.3
20hepatic coma10.2
21megaloblastic anemia10.1
22acute liver failure10.1
23primary biliary cirrhosis10.1
24hemochromatosis10.1
25portal hypertension10.1
26necrotizing fasciitis10.1
27alcoholic neuropathy10.1
28vitiligo10.1
29fasciitis10.1
30gastroenteritis10.1
31hypertension10.1
32meningitis10.1
33multiple myeloma10.1
34myeloma10.1
35neuropathy10.1
36periodontitis10.1
37protein-energy malnutrition10.1
38psoriasis10.1
39purpura10.1
40schistosomiasis10.1
41thyroiditis10.1
42tuberculous peritonitis10.0
43siderosis10.0
44hypotrichosis10.0
45membranoproliferative glomerulonephritis10.0
46iga glomerulonephritis10.0
47acrodermatitis10.0
48extrahepatic cholestasis10.0
49cellulitis10.0
50hemosiderosis10.0

Graphical network of the top 20 diseases related to Alcoholic Liver Cirrhosis:



Diseases related to alcoholic liver cirrhosis

Clinical Features for Alcoholic Liver Cirrhosis

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Drugs & Therapeutics for Alcoholic Liver Cirrhosis

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Sources:
5CenterWatch, 41NIH Clinical Center, 6ClinicalTrials, 60UMLS, 40NDF-RT
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Approved drugs:

Search CenterWatch for Alcoholic Liver Cirrhosis

Drug clinical trials:

Search ClinicalTrials for Alcoholic Liver Cirrhosis

Search NIH Clinical Center for Alcoholic Liver Cirrhosis

Search CenterWatch for Alcoholic Liver Cirrhosis

Genetic Tests for Alcoholic Liver Cirrhosis

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Anatomical Context for Alcoholic Liver Cirrhosis

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30LifeMap Discovery™, 32MalaCards
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MalaCards organs/tissues related to Alcoholic Liver Cirrhosis:

32
Liver, Bone, Bone marrow, Thyroid, Monocytes, T cells, Small intestine, Skin, B cells

LifeMap Discovery
The database of embryonic development, stem cell research and regenerative medicine

Cells/anatomical compartments in embryo or adult related to Alcoholic Liver Cirrhosis:
id TissueAnatomical CompartmentCell Relevance
1 LiverLiver LobuleHepatocytes Affected by disease

Animal Models for Alcoholic Liver Cirrhosis or affiliated genes

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36MGI
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MGI Mouse Phenotypes related to Alcoholic Liver Cirrhosis:

36
idDescriptionMGI Source AccessionScoreTop Affiliating Genes
1MP:00053769.7GSTM1, AKR1A1, GHRH, AHSG, CYP2E1, NAT2

Publications for Alcoholic Liver Cirrhosis

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50PubMed
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Articles related to Alcoholic Liver Cirrhosis:

(show top 50)    (show all 258)
idTitleAuthorsYear
1
Diagnostic significance of nitrates and nitrites and L-arginine, in development of hepatorenal syndrome in patients with end stage alcoholic liver cirrhosis. (23651488)
2013
2
Study of liver transplant rejection in alcoholism-induced cirrhosis. (24314985)
2013
3
Outcomes after liver transplantation for alcoholic hepatitis are similar to alcoholic cirrhosis: exploratory analysis from the UNOS database. (22213344)
2012
4
The outcome of critical illness in decompensated alcoholic liver cirrhosis. (22471740)
2012
5
Polymorphism of N-acetyltransferase 2 gene and the susceptibility to alcoholic liver cirrhosis: interaction with smoking. (21352246)
2011
6
Genetic polymorphism at codon 10 of the transforming growth factor-I^1 gene in patients with alcoholic liver cirrhosis. (21494076)
2011
7
Actinomyces graevenitzii bacteremia in a patient with alcoholic liver cirrhosis. (21421069)
2011
8
Doppler ultrasound of hepatic and system hemodynamics in patients with alcoholic liver cirrhosis. (19277866)
2010
9
Ascites with Strongyloides stercoralis in a patient with acute alcoholic pancreatitis and liver cirrhosis. (19795035)
2009
10
Polymorphism in glutathione-S-transferases: a risk factor in alcoholic liver cirrhosis. (19157724)
2009
11
Focal nodular hyperplasia-like lesion with venous washout in alcoholic liver cirrhosis. (18981634)
2008
12
Focal nodular hyperplasia-like nodules in alcoholic liver cirrhosis: radiologic-pathologic correlation. (17449744)
2007
13
Genetic polymorphism of alcohol dehydrogenase 3 in alcohol liver cirrhosis and in alcohol chronic pancreatitis. (16239350)
2006
14
Unique hypervascular nodules in alcoholic liver cirrhosis: identical to focal nodular hyperplasia-like nodules? (15582133)
2004
15
Clinical characteristics of portal hemodynamics in alcoholic liver cirrhosis. (15318103)
2004
16
Genetic polymorphisms of alcohol-metabolizing enzymes and cytokines in patients with alcohol induced pancreatitis and alcoholic liver cirrhosis]. (15220553)
2004
17
Spontaneous regurgitation of portal blood flow normalized by meal intake in a patient with alcoholic liver cirrhosis. (12644050)
2003
18
Effect of chronic alcohol ingestion on bone mineral density in males without liver cirrhosis. (14619387)
2003
19
Comparison of prevalence for paraumbilical vein patency in patients with viral and alcoholic liver cirrhosis. (12358266)
2002
20
Impact of hepatitis B and C virus infection on the clinical prognosis of alcoholic liver cirrhosis. (11712790)
2001
21
Alterations of IGF-binding proteins in patients with alcoholic liver cirrhosis. (11091025)
2000
22
Norfloxacin-induced acute cholestatic hepatitis in a patient with alcoholic liver cirrhosis. (10445586)
1999
23
Hepatic veno-occlusive lesions in severe alcoholic hepatitis and alcoholic liver cirrhosis: a comparative histopathological study in autopsy cases. (10235278)
1999
24
Aeromonas sobria infection with severe soft tissue damage and segmental necrotizing gastroenteritis in a patient with alcoholic liver cirrhosis. (10469397)
1999
25
S-adenosylmethionine in alcoholic liver cirrhosis: a randomized, placebo-controlled, double-blind, multicenter clinical trial. (10406187)
1999
26
Coagulation inhibitors in alcoholic liver cirrhosis. (9426833)
1998
27
Serum and ascitic levels of soluble intercellular adhesion molecule-1 in patients with alcoholic liver cirrhosis: relation to biochemical markers of disease activity and alcohol intake. (8865970)
1996
28
Platelet serotonin (5-HT) content is decreased in patients with alcoholic liver cirrhosis, but elevated in Gilbert's syndrome. (8938562)
1996
29
Thallium-201 per rectal scintigraphy improves prognostic evaluation in alcoholic liver cirrhosis of low and mid severity. (7661170)
1995
30
Association of a restriction fragment length polymorphism in the alcohol dehydrogenase 2 gene with Japanese alcoholic liver cirrhosis. (8583138)
1995
31
Spontaneous bacterial peritonitis and culture negative neutrocytic ascites in patients with non-alcoholic liver cirrhosis. (7827291)
1994
32
Liver transplantation for alcoholic liver disease: survival of patients transplanted with alcoholic hepatitis plus cirrhosis as compared with those with cirrhosis alone. (8279673)
1993
33
The concentration of thiamin and thiamin phosphate esters in patients with alcoholic liver cirrhosis. (1476555)
1992
34
Polymorphism of alcohol dehydrogenase, alcohol and aldehyde dehydrogenase activities: implication in alcoholic cirrhosis in white patients. The French Group for Research on Alcohol and Liver. (1592339)
1992
35
Genetic markers in alcoholic liver cirrhosis. (1512005)
1992
36
Determination of alcohol dehydrogenase genotype: no correlation between isoenzyme pattern and liver cirrhosis]. (1759148)
1991
37
Morphologic changes of small intestine epithelium in the course of post-alcoholic liver cirrhosis. (2347293)
1990
38
Studies on the monocyte interleukin-1 and tumour necrosis factor-alpha production in patients with alcoholic liver cirrhosis. (2636361)
1989
39
Depressed monocyte production of interleukin-1 and tumor necrosis factor-alpha in patients with alcoholic liver cirrhosis. (2586242)
1989
40
Impaired early insulin response to intravenous glucose in alcoholic liver cirrhosis. (3296134)
1987
41
Relationship between degree of portal hypertension and liver histologic lesions in patients with alcoholic cirrhosis. Effect of acute alcoholic hepatitis on portal hypertension. (3829877)
1987
42
Cell-mediated immunity in alcoholic liver cirrhosis. (3613967)
1987
43
Haemodynamic response to exercise in patients with alcoholic liver cirrhosis. (3816110)
1987
44
Decreased susceptibility of red blood cells to lipid peroxidation in patients with alcoholic liver cirrhosis. (3987030)
1985
45
Frequency of hyperprolinemia in alcoholic liver cirrhosis: relationship to blood lactate. (6706303)
1984
46
Oral testosterone load related to liver function in men with alcoholic liver cirrhosis. (6673064)
1983
47
Human leucocyte antigens in patients with alcoholic liver cirrhosis. (7433893)
1980
48
Esophageal varices, splenic pulp pressure and "directional" flow patterns in alcoholic liver cirrhosis. (4734449)
1973
49
The natural history of esophageal varices in patients with alcoholic liver cirrhosis. An endoscopic and clinical study. (4538104)
1972
50
The "augmented secretin test" in patients with alcoholic liver cirrhosis. Preliminary report. (5525652)
1970

Genetic Variations for Alcoholic Liver Cirrhosis

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Expression for genes affiliated with Alcoholic Liver Cirrhosis

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Sources:
1BioGPS, 15Gene Expression Omnibus DataSets
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Expression patterns in normal tissues for genes affiliated with Alcoholic Liver Cirrhosis

Search GEO for disease gene expression data for Alcoholic Liver Cirrhosis.

Pathways for genes affiliated with Alcoholic Liver Cirrhosis

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Sources:
49PharmGKB, 37NCBI BioSystems Database, 12EMD Millipore, 29KEGG, 53Reactome
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Pathways related to Alcoholic Liver Cirrhosis according to GeneCards/GeneDecks:

(show all 19)
idSuper pathways (with members indented)ScoreTop Affiliating Genes
1
Hide members
10.3ADH1B, ADH1A
2
Hide members
10.3ADH1B, ADH4, ALDH2
3
Hide members
10.3CYP2E1, ALDH2, ADH1B
4
Hide members
10.3CYP2E1, CYP2A6, ADH1B
5
Retinol metabolism
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10.3ALDH2, CYP2A6, CYP2E1
6
Acetaminophen metabolism
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10.3CYP2E1, CYP2A6, NAT2
7
Hide members
10.3NAT2, CYP2A6, CYP2E1
810.3ADH4, ADH1A, CYP2E1
910.3ADH1A, ADH1C, ADH1B
10
Hide members
10.2AKR1A1, CYP2A6, ALDH2, ADH1B
11
Naphthalene metabolism
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10.2AKR1A1, CYP2E1, CYP2A6, GSTM1
12
Hide members
10.2ADH1A, ADH4, ADH1C, ADH1B, ADH7
13
Hide members
10.1ALDH2, ADH1A, ADH4, ADH1C, ADH1B, ADH7
14
Hide members
10.1ALDH2, ADH7, ADH1B, ADH1C, ADH4, ADH1A
15
Hide members
10.0AKR1A1, ALDH2, ADH1A, ADH4, ADH1C, ADH1B
16
Hide members
9.9CYP2E1, CYP2A6, NAT2, ADH1A, ADH4, ADH1C
17
Hide members
9.9ADH7, ADH1B, ADH1C, ADH4, ADH1A, ALDH2
18
Hide members
9.8GSTM1, ADH7, ADH1B, ADH1C, ADH4, ADH1A
19
Hide members
9.8NAT2, PGD, TAT, PLIN2, ALDH2, ADH1A

Compounds for genes affiliated with Alcoholic Liver Cirrhosis

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11DrugBank, 44Novoseek, 24HMDB, 49PharmGKB, 59Tocris Bioscience, 28IUPHAR
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Compounds related to Alcoholic Liver Cirrhosis according to GeneCards/GeneDecks:

(show top 50)    (show all 143)
idCompoundScoreTop Affiliating Genes
14-Iodopyrazole1110.7ADH1B, ADH1C, ADH1A
21-methylxanthine44 2411.7CYP2E1, CYP2A6, NAT2
34-methylpyrazole4410.7AKR1A1, CYP2E1, CYP2A6
4vinylchloride4410.7CYP2E1, ALDH2, GSTM1
5dimethylnitrosamine4410.7NAT2, CYP2A6, CYP2E1
6debrisoquine4410.6CYP2E1, GSTM1, NAT2, CYP2A6
7pyrazole44 1111.6AKR1A1, CYP2E1, ADH1C, CYP2A6
8mephenytoin44 49 1112.6CYP2A6, NAT2, CYP2E1
9trichloroethylene4410.6CYP2E1, GSTM1, NAT2, AKR1A1
10isoniazid49 44 1112.6CYP2E1, CYP2A6, NAT2, GSTM1
11mspi4410.6ADH1B, CYP2E1, NAT2, GSTM1
12gsts4410.6GSTM1, ALDH2, NAT2, CYP2E1
13Fomepizole1110.6CYP2A6, ADH1A, ADH1B, ADH1C, CYP2E1
14toluene4410.6CYP2E1, ALDH2, GSTM1
15styrene4410.6NAT2, GSTM1, CYP2E1
16betaine aldehyde44 2411.6ADH7, ADH1B, ADH1A, ALDH2, ADH1C
17midazolam44 49 1112.6NAT2, CYP2A6, GABRG2, CYP2E1
18disulfiram44 59 1112.6AKR1A1, CYP2E1, ALDH2, CYP2A6
191-hydroxypyrene4410.6CYP2E1, GSTM1, NAT2
20epoxide4410.6GSTM1, NAT2, AKR1A1, CYP2A6, CYP2E1
21rifampicin44 28 5912.6CYP2A6, CYP2E1, TAT, NAT2
22cimetidine44 28 1112.5AKR1A1, CYP2E1, CYP2A6, ADH7
23paraoxon44 2411.5CYP2E1, NAT2, CYP2A6
24formaldehyde44 2411.5CYP2E1, ADH1C, AKR1A1, CYP2A6, ESD, ALDH2
25betacarotene4410.5GSTM1, ALDH2, CYP2E1, NAT2
26Nicotinamide-Adenine-Dinucleotide1110.5AKR1A1, ADH1A, ADH7, ADH1B, ADH1C, ADH4
27polyacrylamide4410.5ALDH2, AHSG, AKR1A1, PGD, ESD, ADH1B
28benzyl alcohol44 1111.5CYP2E1, ALDH2, AKR1A1
29nad28 2411.5AKR1A1, ALDH2, ADH1A, ADH4, ADH1C, ADH1B
30acetaldehyde44 28 2412.4AKR1A1, CYP2E1, CYP2A6, ALDH2, ADH1A, ADH1C
31rsai4410.4ADH1B, ADH1C, ALDH2, NAT2, CYP2E1, AKR1A1
32dopamine44 28 11 2413.4ADH1B, GSTM1, ALDH2, AKR1A1, GHRH, CYP2E1
33nadh44 11 2412.4ADH1B, ADH1C, ADH4, ADH1A, ALDH2, PGD
34methotrexate44 49 1112.4TAT, GSTM1, PGD, NAT2, LSL
35aspartate4410.4AKR1A1, GHRH, PGD, TAT, ALDH2, GSTM1
364-hydroxynonenal44 2411.4GSTM1, AKR1A1, CYP2E1, ALDH2
37glucose4410.4GHRH, LSL, ADH1B, PGD, AHSG, ALDH2
38nadph44 2411.3ADH7, CYP2E1, CYP2A6, AKR1A1, PGD, ALDH2
39vitamin a44 11 2412.3AKR1A1, CYP2E1, NAT2, ALDH2, ADH1A, ADH4
40glycerol44 11 2412.3ADH1C, CYP2E1, ADH1B, TAT, LSL, AKR1A1
41cotinine44 2411.3NAT2, CYP2A6, GSTM1
42phenobarbital44 28 1112.3AKR1A1, CYP2E1, CYP2A6, GSTM1
43oxygen44 2411.3GSTM1, CYP2E1, AKR1A1, LSL, ALDH2, TAT
44lactate4410.3LSL, AKR1A1, CYP2E1, GSTM1, TAT, PGD
45retinoid4410.2ALDH2, ADH7, ADH4, ADH1A, AKR1A1
46retinoic acid44 2411.2ADH7, AKR1A1, ALDH2, ADH1A, TAT, CYP2A6
47nash4410.2AKR1A1, LSL, CYP2E1
48ethanol44 49 11 2413.1TAT, AHSG, GHRH, AKR1A1, ASGR2, ALDH2
49flurazepam44 1111.0CYP2E1, CYP2A6, GABRG2
50zinc44 2411.0ADH1A, TAT, ADH1C, LSL, ADH7, ADH1B

GO Terms for genes affiliated with Alcoholic Liver Cirrhosis

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16Gene Ontology
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Cellular components related to Alcoholic Liver Cirrhosis according to GeneCards/GeneDecks:

idNameGO IDScoreTop Affiliating Genes
1cytosolGO:0058299.8GSTM1, NAT2, PGD, TAT, ADH1A, ADH4

Biological processes related to Alcoholic Liver Cirrhosis according to GeneCards/GeneDecks:

(show all 9)
idNameGO IDScoreTop Affiliating Genes
1alcohol metabolic processGO:00606610.4ADH4, ADH1A, ALDH2
2retinol metabolic processGO:04257210.4ADH7, ADH4
3ethanol catabolic processGO:00606810.4ADH7, ALDH2
4drug metabolic processGO:01714410.3CYP2E1, CYP2A6, ADH1A
5ethanol oxidationGO:00606910.3ALDH2, ADH1A, ADH4, ADH1C, ADH1B, ADH7
6cellular aldehyde metabolic processGO:00608110.2ADH4, AKR1A1
7xenobiotic metabolic processGO:00680510.1GSTM1, CYP2E1, CYP2A6, NAT2, ALDH2, ADH1A
8oxidation-reduction processGO:05511410.0CYP2E1, PGD, ADH7
9small molecule metabolic processGO:0442819.8CYP2E1, CYP2A6, NAT2, PGD, TAT, PLIN2

Molecular functions related to Alcoholic Liver Cirrhosis according to GeneCards/GeneDecks:

(show all 7)
idNameGO IDScoreTop Affiliating Genes
1alcohol dehydrogenase activity, zinc-dependentGO:00402410.4ADH7, ADH1B, ADH4, ADH1A
2retinol dehydrogenase activityGO:00474510.4ADH7, ADH4
3alditol:NADP+ 1-oxidoreductase activityGO:00403210.3ADH4, AKR1A1
4alcohol dehydrogenase (NAD) activityGO:00402210.3ADH1A, ADH4, ADH1C, ADH7
5electron carrier activityGO:00905510.3AKR1A1, CYP2E1, CYP2A6, ALDH2
6oxidoreductase activity, acting on paired donors, with incorporation or reduction of molecular oxygen, reduced flavin or flavoprGO:01671210.3CYP2E1, CYP2A6
7retinol bindingGO:01984110.1ADH7, ADH4

Products for genes affiliated with Alcoholic Liver Cirrhosis

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Sources for Alcoholic Liver Cirrhosis

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3CDC
13ExPASy
14FMA
22GTR
23HGMD
24HMDB
25ICD10
26ICD10 via Orphanet
27ICD9CM
28IUPHAR
29KEGG
34MeSH
35MESH via Orphanet
36MGI
39NCIt
40NDF-RT
43NINDS
44Novoseek
46OMIM
47OMIM via Orphanet
50PubMed
51QIAGEN
57SNOMED-CT via Orphanet
60UMLS
61UMLS via Orphanet