MCID: ALC009
MIFTS: 55

Alcoholic Liver Cirrhosis malady

Gastrointestinal diseases, Liver diseases categories

Summaries for Alcoholic Liver Cirrhosis

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32MalaCards
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MalaCards: Alcoholic Liver Cirrhosis, also known as portal cirrhosis, is related to liver cirrhosis and hepatitis. An important gene associated with Alcoholic Liver Cirrhosis is ADH1C (alcohol dehydrogenase 1C (class I), gamma polypeptide), and among its related pathways are Doxepin Pathway, Pharmacokinetics and phenylalanine utilization. The compounds 4-Iodopyrazole and 1-methylxanthine have been mentioned in the context of this disorder. Affiliated tissues include liver, bone and bone marrow, and related mouse phenotype homeostasis/metabolism.

Aliases & Classifications for Alcoholic Liver Cirrhosis

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8Disease Ontology, 10DISEASES, 44Novoseek, 60UMLS, 56SNOMED-CT, 39NCIt, 27ICD9CM, 34MeSH, 25ICD10
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Classifications:

Malacards categories (disease lists): (See all malacards categories)
Anatomical: Gastrointestinal diseases, Liver diseases


Aliases & Descriptions:

alcoholic liver cirrhosis 8 10
portal cirrhosis 8 44 60
alcoholic cirrhosis 8 44
laennec's cirrhosis, alcoholic 8
alcoholic cirrhosis of liver 8
portal cirrhosis unspecified 8
liver cirrhosis, alcoholic 60
laennec's cirrhosis 8


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Disease Ontology8 DOID:14018
NCIt39 C34782
ICD9CM27 571.2
MeSH34 D008104
ICD1025 K70.3

Related Diseases for Alcoholic Liver Cirrhosis

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17GeneCards, 18GeneDecks
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Diseases related to Alcoholic Liver Cirrhosis via text searches within MalaCards or GeneCards/GeneDecks gene sharing:

(show top 50)    (show all 101)
idRelated DiseaseScoreTop Affiliating Genes
1liver cirrhosis31.9AKR1A1, LSL, GHRH, CYP2E1, ADH1B, ADH1C
2hepatitis31.1TAT, CYP2E1, ASGR2
3hepatitis c30.8ASGR2, LSL, CYP2E1
4pancreatitis30.8CYP2E1, ALDH2, ADH1C, ADH1B
5alcoholic pancreatitis30.8ADH1C, AKR1A1, CYP2E1, ALDH2, ADH1B
6hepatocellular carcinoma30.5ADH1B, AHSG, AKR1A1, CYP2A6, NAT2, TAT
7alcohol dependence30.4ADH1B, ADH1A, ADH4, ADH7, ALDH2
8hepatitis b30.4TAT, ALDH2, NAT2, ASGR2
9fatty liver disease30.2CYP2E1
10alcohol abuse30.2ALDH2, CYP2E1, AKR1A1, ADH1C
11viral hepatitis30.2ADH1B, CYP2A6, AKR1A1
12diabetes mellitus30.2ALDH2, NAT2, CYP2E1, AHSG, LSL
13alcoholic hepatitis10.8
14peritonitis10.5
15hepatitis a10.4
16esophagitis10.4
17liver disease10.4
18calciphylaxis10.3
19hepatorenal syndrome10.3
20hepatic coma10.2
21megaloblastic anemia10.1
22acute liver failure10.1
23primary biliary cirrhosis10.1
24hemochromatosis10.1
25portal hypertension10.1
26necrotizing fasciitis10.1
27alcoholic neuropathy10.1
28vitiligo10.1
29fasciitis10.1
30gastroenteritis10.1
31hypertension10.1
32meningitis10.1
33multiple myeloma10.1
34myeloma10.1
35neuropathy10.1
36periodontitis10.1
37protein-energy malnutrition10.1
38psoriasis10.1
39purpura10.1
40schistosomiasis10.1
41thyroiditis10.1
42tuberculous peritonitis10.0
43siderosis10.0
44hypotrichosis10.0
45membranoproliferative glomerulonephritis10.0
46iga glomerulonephritis10.0
47acrodermatitis10.0
48extrahepatic cholestasis10.0
49cellulitis10.0
50hemosiderosis10.0

Graphical network of the top 20 diseases related to Alcoholic Liver Cirrhosis:



Diseases related to alcoholic liver cirrhosis

Clinical Features for Alcoholic Liver Cirrhosis

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Drugs & Therapeutics for Alcoholic Liver Cirrhosis

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Sources:
5CenterWatch, 41NIH Clinical Center, 6ClinicalTrials, 60UMLS, 40NDF-RT
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Approved drugs:

Search CenterWatch for Alcoholic Liver Cirrhosis

Drug clinical trials:

Search ClinicalTrials for Alcoholic Liver Cirrhosis

Search NIH Clinical Center for Alcoholic Liver Cirrhosis

Search CenterWatch for Alcoholic Liver Cirrhosis

Genetic Tests for Alcoholic Liver Cirrhosis

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Anatomical Context for Alcoholic Liver Cirrhosis

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30LifeMap Discovery™, 32MalaCards
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MalaCards organs/tissues related to Alcoholic Liver Cirrhosis:

32
Liver, Bone, Bone marrow, Thyroid, Monocytes, T cells, Small intestine, Skin, B cells

LifeMap Discovery
The database of embryonic development, stem cell research and regenerative medicine

Cells/anatomical compartments in embryo or adult related to Alcoholic Liver Cirrhosis:
id TissueAnatomical CompartmentCell Relevance
1 LiverLiver LobuleHepatocytes Affected by disease

Animal Models for Alcoholic Liver Cirrhosis or affiliated genes

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36MGI
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MGI Mouse Phenotypes related to Alcoholic Liver Cirrhosis:

36
idDescriptionMGI Source AccessionScoreTop Affiliating Genes
1MP:00053769.7GSTM1, AKR1A1, GHRH, AHSG, CYP2E1, NAT2

Publications for Alcoholic Liver Cirrhosis

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50PubMed
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Articles related to Alcoholic Liver Cirrhosis:

(show top 50)    (show all 258)
idTitleAuthorsYear
1
Serum amyloid A and C-reactive protein positive nodule in alcoholic liver cirrhosis, hard to make definite diagnosis. (23607539)
2013
2
Characteristics of alcoholic liver disease and predictive factors for mortality of patients with alcoholic cirrhosis. (24322744)
2013
3
Iliopsoas muscle hematoma secondary to alcoholic liver cirrhosis. (23185153)
2012
4
Diagnostical significance of dimethylarginine in the development of hepatorenal syndrome in patients with alcoholic liver cirrhosis. (22924265)
2012
5
Detection of alcohol consumption in patients with alcoholic liver cirrhosis during the evaluation process for liver transplantation. (22577089)
2012
6
Emotional-type psychopathologic symptoms among patients with terminal chronic alcohol-induced liver cirrhosis. (22841199)
2012
7
The PNPLA3 rs738409 148M/M genotype is a risk factor for liver cancer in alcoholic cirrhosis but shows no or weak association in hepatitis C cirrhosis. (22087248)
2011
8
Evaluation of quantitative portal venous, hepatic arterial, and total hepatic tissue blood flow using xenon CT in alcoholic liver cirrhosis-comparison with liver cirrhosis related to hepatitis C virus and nonalcoholic steatohepatitis. (18986379)
2010
9
Complications of alcoholic liver cirrhosis: active assessment by endoscopy and sonography. (20672382)
2010
10
Alcohol abstinence and orthotopic liver transplantation in alcoholic liver cirrhosis. (19460531)
2009
11
A functional polymorphism of the NFKB1 gene increases the risk for alcoholic liver cirrhosis in patients with alcohol dependence. (19673747)
2009
12
Thyroid dysfunction in primary biliary cirrhosis, primary sclerosing cholangitis and non-alcoholic fatty liver disease. (19291181)
2009
13
Alcohol dehydrogenase and aldehyde dehydrogenase gene polymorphism in alcohol liver cirrhosis and alcohol chronic pancreatitis among Polish individuals. (17454860)
2007
14
Auxiliary partial orthotopic living donor liver transplantation in a patient with alcoholic liver cirrhosis to overcome donor steatosis. (16623878)
2006
15
The influence of genetic polymorphism of CYP2E1 on the development of alcohol liver cirrhosis]. (17427487)
2006
16
Erythropoietin increases platelet reactivity and platelet counts in patients with alcoholic liver cirrhosis: a randomized, double-blind, placebo-controlled study. (15298638)
2004
17
Clinicopathological study of hepatic nodular lesions in patients with alcoholic liver cirrhosis. (15318110)
2004
18
Computerized morphometry of the cirrhotic liver: comparative analysis in primary biliary cirrhosis, alcoholic cirrhosis, and posthepatitic cirrhosis. (15605407)
2004
19
Auxiliary partial orthotopic living donor liver transplantation for alcoholic liver cirrhosis: a case report. (12591433)
2003
20
Indication of liver transplantation in severe alcoholic liver cirrhosis: quantitative evaluation and optimal timing. (11804670)
2002
21
Studies on the mechanism of elevation of serum PIVKA-II levels in alcoholic liver cirrhosis]. (11985059)
2002
22
Serum cytokine levels in alcohol-related liver cirrhosis. (11282449)
2001
23
Serum leptin levels in alcoholic liver cirrhosis: relationship with gender, nutritional status, liver function and energy metabolism. (11641747)
2001
24
Effect of treatment with acarbose and insulin in patients with non-insulin-dependent diabetes mellitus associated with non-alcoholic liver cirrhosis. (11213597)
2001
25
Influence of smoking on cotinine and caffeine plasma levels in patients with alcoholic liver cirrhosis. (10806124)
2000
26
Simultaneous elevation of serum amylase and lipase levels due to multiclass immunoglobulin-bound enzymes in a patient with alcoholic liver cirrhosis. (10231851)
1999
27
Orthotopic liver transplantation in alcoholic liver cirrhosis. (10500685)
1999
28
Alcoholic liver cirrhosis after the advent of hepatitis C virus: some reflections on its epidemiology and on the concept of attributable risk. Collaborative GESIA and AISF Groups. Gruppo Epidemiologico della SocietA Italiana di Alcologia and Associazione Italiana per lo Studio del Fegato. (9265584)
1997
29
Isoprinosine and levamisole as stimulators of interferon production in blood leukocytes of patients with alcoholic liver cirrhosis. (9597085)
1997
30
Relevance of ICAM-1 to alcoholic liver cirrhosis. (8856795)
1996
31
Effect of alcohol abuse and glutathione administration on the circulating levels of glutathione and on antipyrine metabolism in patients with alcoholic liver cirrhosis. (8869667)
1996
32
Distribution of peripheral blood lymphoid subsets in alcoholic liver cirrhosis: influence of ethanol intake. (8986204)
1996
33
Circulating enzyme activities of collagen turnover and undulin in patients with various degrees of schistosomiasis and alcoholic liver cirrhosis. (7782029)
1995
34
Circulating ICAM-1 in alcoholic liver cirrhosis. (7888794)
1995
35
Nutritional assessment and adequacy of dietary intake in hospitalized patients with alcoholic liver cirrhosis. (8329343)
1993
36
Hepatitis C virus infection as a risk factor for non-alcoholic liver cirrhosis in Taiwan. (7508973)
1993
37
Hepatitis C virus infection in alcoholic liver cirrhosis in Japan: its contribution to the development of hepatocellular carcinoma. (8141927)
1993
38
Reduced concentration of hepatic alpha-tocopherol in patients with alcoholic liver cirrhosis. (1580927)
1992
39
Delayed increases in liver cirrhosis mortality and frequency of alcoholic liver cirrhosis following an increment and redistribution of alcohol consumption in Finland: evidence from mortality statistics and autopsy survey covering 8533 cases in 1968-1988. (1530126)
1992
40
Insulin-like growth factor I: a good indicator of functional hepatocellular capacity in alcoholic liver cirrhosis. (1865082)
1991
41
Chronic zinc deficiency in a patient with psoriasis and alcoholic liver cirrhosis. (1993565)
1991
42
Hepatocyte and nuclear areas in alcoholic liver cirrhosis: their relationship with the size of the nodules and the degree of fibrosis. (3608794)
1987
43
The wetness of drinking cultures: a key variable in epidemiology of alcoholic liver cirrhosis. (3867240)
1985
44
T-cell subsets in peripheral blood and ascitic fluid of patients with alcoholic liver cirrhosis. (6136678)
1983
45
Reticuloendothelial function in patients with alcoholic liver cirrhosis. (7323686)
1981
46
Autoantibodies in alcoholic liver cirrhosis in Portugal. (6972152)
1981
47
Effect of food intake on circulating antigen-antibody complexes in patients with alcoholic liver cirrhosis. (710740)
1978
48
Gastric clearance of serum albumin in patients with alcoholic liver cirrhosis. (964474)
1976
49
Liver disease and alcohol: fatty liver, alcoholic hepatitis, cirrhosis, and their interrelationships. (50030)
1975
50
Carbohydrate metabolism in patients with alcoholic liver cirrhosis. (1177523)
1975

Genetic Variations for Alcoholic Liver Cirrhosis

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Expression for genes affiliated with Alcoholic Liver Cirrhosis

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Sources:
1BioGPS, 15Gene Expression Omnibus DataSets
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Expression patterns in normal tissues for genes affiliated with Alcoholic Liver Cirrhosis

Search GEO for disease gene expression data for Alcoholic Liver Cirrhosis.

Pathways for genes affiliated with Alcoholic Liver Cirrhosis

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Sources:
49PharmGKB, 37NCBI BioSystems Database, 12EMD Millipore, 29KEGG, 53Reactome
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Pathways related to Alcoholic Liver Cirrhosis according to GeneCards/GeneDecks:

(show all 19)
idSuper pathways (with members indented)ScoreTop Affiliating Genes
1
Hide members
10.3ADH1B, ADH1A
2
Hide members
10.3ADH1B, ADH4, ALDH2
3
Hide members
10.3CYP2E1, ALDH2, ADH1B
4
Hide members
10.3CYP2E1, CYP2A6, ADH1B
5
Retinol metabolism
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10.3ALDH2, CYP2A6, CYP2E1
6
Acetaminophen metabolism
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10.3CYP2E1, CYP2A6, NAT2
7
Hide members
10.3NAT2, CYP2A6, CYP2E1
810.3ADH4, ADH1A, CYP2E1
910.3ADH1A, ADH1C, ADH1B
10
Hide members
10.2AKR1A1, CYP2A6, ALDH2, ADH1B
11
Naphthalene metabolism
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10.2AKR1A1, CYP2E1, CYP2A6, GSTM1
12
Hide members
10.2ADH1A, ADH4, ADH1C, ADH1B, ADH7
13
Hide members
10.1ALDH2, ADH1A, ADH4, ADH1C, ADH1B, ADH7
14
Hide members
10.1ALDH2, ADH7, ADH1B, ADH1C, ADH4, ADH1A
15
Hide members
10.0AKR1A1, ALDH2, ADH1A, ADH4, ADH1C, ADH1B
16
Hide members
9.9CYP2E1, CYP2A6, NAT2, ADH1A, ADH4, ADH1C
17
Hide members
9.9ADH7, ADH1B, ADH1C, ADH4, ADH1A, ALDH2
18
Hide members
9.8GSTM1, ADH7, ADH1B, ADH1C, ADH4, ADH1A
19
Hide members
9.8NAT2, PGD, TAT, PLIN2, ALDH2, ADH1A

Compounds for genes affiliated with Alcoholic Liver Cirrhosis

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Sources:
11DrugBank, 44Novoseek, 24HMDB, 49PharmGKB, 59Tocris Bioscience, 28IUPHAR
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Compounds related to Alcoholic Liver Cirrhosis according to GeneCards/GeneDecks:

(show top 50)    (show all 143)
idCompoundScoreTop Affiliating Genes
14-Iodopyrazole1110.7ADH1B, ADH1C, ADH1A
21-methylxanthine44 2411.7CYP2E1, CYP2A6, NAT2
34-methylpyrazole4410.7AKR1A1, CYP2E1, CYP2A6
4vinylchloride4410.7CYP2E1, ALDH2, GSTM1
5dimethylnitrosamine4410.7NAT2, CYP2A6, CYP2E1
6debrisoquine4410.6CYP2E1, GSTM1, NAT2, CYP2A6
7pyrazole44 1111.6AKR1A1, CYP2E1, ADH1C, CYP2A6
8mephenytoin44 49 1112.6CYP2A6, NAT2, CYP2E1
9trichloroethylene4410.6CYP2E1, GSTM1, NAT2, AKR1A1
10isoniazid49 44 1112.6CYP2E1, CYP2A6, NAT2, GSTM1
11mspi4410.6ADH1B, CYP2E1, NAT2, GSTM1
12gsts4410.6GSTM1, ALDH2, NAT2, CYP2E1
13Fomepizole1110.6CYP2A6, ADH1A, ADH1B, ADH1C, CYP2E1
14toluene4410.6CYP2E1, ALDH2, GSTM1
15styrene4410.6NAT2, GSTM1, CYP2E1
16betaine aldehyde44 2411.6ADH7, ADH1B, ADH1A, ALDH2, ADH1C
17midazolam44 49 1112.6NAT2, CYP2A6, GABRG2, CYP2E1
18disulfiram44 59 1112.6AKR1A1, CYP2E1, ALDH2, CYP2A6
191-hydroxypyrene4410.6CYP2E1, GSTM1, NAT2
20epoxide4410.6GSTM1, NAT2, AKR1A1, CYP2A6, CYP2E1
21rifampicin44 28 5912.6CYP2A6, CYP2E1, TAT, NAT2
22cimetidine44 28 1112.5AKR1A1, CYP2E1, CYP2A6, ADH7
23paraoxon44 2411.5CYP2E1, NAT2, CYP2A6
24formaldehyde44 2411.5CYP2E1, ADH1C, AKR1A1, CYP2A6, ESD, ALDH2
25betacarotene4410.5GSTM1, ALDH2, CYP2E1, NAT2
26Nicotinamide-Adenine-Dinucleotide1110.5AKR1A1, ADH1A, ADH7, ADH1B, ADH1C, ADH4
27polyacrylamide4410.5ALDH2, AHSG, AKR1A1, PGD, ESD, ADH1B
28benzyl alcohol44 1111.5CYP2E1, ALDH2, AKR1A1
29nad28 2411.5AKR1A1, ALDH2, ADH1A, ADH4, ADH1C, ADH1B
30acetaldehyde44 28 2412.4AKR1A1, CYP2E1, CYP2A6, ALDH2, ADH1A, ADH1C
31rsai4410.4ADH1B, ADH1C, ALDH2, NAT2, CYP2E1, AKR1A1
32dopamine44 28 11 2413.4ADH1B, GSTM1, ALDH2, AKR1A1, GHRH, CYP2E1
33nadh44 11 2412.4ADH1B, ADH1C, ADH4, ADH1A, ALDH2, PGD
34methotrexate44 49 1112.4TAT, GSTM1, PGD, NAT2, LSL
35aspartate4410.4AKR1A1, GHRH, PGD, TAT, ALDH2, GSTM1
364-hydroxynonenal44 2411.4GSTM1, AKR1A1, CYP2E1, ALDH2
37glucose4410.4GHRH, LSL, ADH1B, PGD, AHSG, ALDH2
38nadph44 2411.3ADH7, CYP2E1, CYP2A6, AKR1A1, PGD, ALDH2
39vitamin a44 11 2412.3AKR1A1, CYP2E1, NAT2, ALDH2, ADH1A, ADH4
40glycerol44 11 2412.3ADH1C, CYP2E1, ADH1B, TAT, LSL, AKR1A1
41cotinine44 2411.3NAT2, CYP2A6, GSTM1
42phenobarbital44 28 1112.3AKR1A1, CYP2E1, CYP2A6, GSTM1
43oxygen44 2411.3GSTM1, CYP2E1, AKR1A1, LSL, ALDH2, TAT
44lactate4410.3LSL, AKR1A1, CYP2E1, GSTM1, TAT, PGD
45retinoid4410.2ALDH2, ADH7, ADH4, ADH1A, AKR1A1
46retinoic acid44 2411.2ADH7, AKR1A1, ALDH2, ADH1A, TAT, CYP2A6
47nash4410.2AKR1A1, LSL, CYP2E1
48ethanol44 49 11 2413.1TAT, AHSG, GHRH, AKR1A1, ASGR2, ALDH2
49flurazepam44 1111.0CYP2E1, CYP2A6, GABRG2
50zinc44 2411.0ADH1A, TAT, ADH1C, LSL, ADH7, ADH1B

GO Terms for genes affiliated with Alcoholic Liver Cirrhosis

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Sources:
16Gene Ontology
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Cellular components related to Alcoholic Liver Cirrhosis according to GeneCards/GeneDecks:

idNameGO IDScoreTop Affiliating Genes
1cytosolGO:0058299.8GSTM1, NAT2, PGD, TAT, ADH1A, ADH4

Biological processes related to Alcoholic Liver Cirrhosis according to GeneCards/GeneDecks:

(show all 9)
idNameGO IDScoreTop Affiliating Genes
1alcohol metabolic processGO:00606610.4ADH4, ADH1A, ALDH2
2retinol metabolic processGO:04257210.4ADH7, ADH4
3ethanol catabolic processGO:00606810.4ADH7, ALDH2
4drug metabolic processGO:01714410.3CYP2E1, CYP2A6, ADH1A
5ethanol oxidationGO:00606910.3ALDH2, ADH1A, ADH4, ADH1C, ADH1B, ADH7
6cellular aldehyde metabolic processGO:00608110.2ADH4, AKR1A1
7xenobiotic metabolic processGO:00680510.1GSTM1, CYP2E1, CYP2A6, NAT2, ALDH2, ADH1A
8oxidation-reduction processGO:05511410.0CYP2E1, PGD, ADH7
9small molecule metabolic processGO:0442819.8CYP2E1, CYP2A6, NAT2, PGD, TAT, PLIN2

Molecular functions related to Alcoholic Liver Cirrhosis according to GeneCards/GeneDecks:

(show all 7)
idNameGO IDScoreTop Affiliating Genes
1alcohol dehydrogenase activity, zinc-dependentGO:00402410.4ADH7, ADH1B, ADH4, ADH1A
2retinol dehydrogenase activityGO:00474510.4ADH7, ADH4
3alditol:NADP+ 1-oxidoreductase activityGO:00403210.3ADH4, AKR1A1
4alcohol dehydrogenase (NAD) activityGO:00402210.3ADH1A, ADH4, ADH1C, ADH7
5electron carrier activityGO:00905510.3AKR1A1, CYP2E1, CYP2A6, ALDH2
6oxidoreductase activity, acting on paired donors, with incorporation or reduction of molecular oxygen, reduced flavin or flavoprGO:01671210.3CYP2E1, CYP2A6
7retinol bindingGO:01984110.1ADH7, ADH4

Products for genes affiliated with Alcoholic Liver Cirrhosis

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  • Antibodies
  • Proteins
  • Lysates
  • Antibodies

Sources for Alcoholic Liver Cirrhosis

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3CDC
13ExPASy
14FMA
22GTR
23HGMD
24HMDB
25ICD10
26ICD10 via Orphanet
27ICD9CM
28IUPHAR
29KEGG
34MeSH
35MESH via Orphanet
36MGI
39NCIt
40NDF-RT
43NINDS
44Novoseek
46OMIM
47OMIM via Orphanet
50PubMed
51QIAGEN
57SNOMED-CT via Orphanet
60UMLS
61UMLS via Orphanet