MCID: ALC011
MIFTS: 31

Alcoholic Neuropathy malady

Neuronal diseases category

Summaries for Alcoholic Neuropathy

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66Wikipedia, 34MalaCards
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Wikipedia:66 Alcoholic polyneuropathy (A.K.A alcohol leg) is a neurological disorder in which multiple peripheral... more...

MalaCards: Alcoholic Neuropathy, also known as alcohol-related polyneuropathy, is related to neuropathy and polyneuropathy. An important gene associated with Alcoholic Neuropathy is ALDH2 (aldehyde dehydrogenase 2 family (mitochondrial)), and among its related pathways is Metabolism. The drugs hydroxocobalamin and thiamine and the compound cholesterol have been mentioned in the context of this disorder. Affiliated tissues include liver and skin, and related mouse phenotype reproductive system.

Aliases & Classifications for Alcoholic Neuropathy

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9Disease Ontology, 11DISEASES, 46Novoseek, 63UMLS, 28ICD9CM, 41NCIt, 36MeSH, 59SNOMED-CT, 26ICD10
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Classifications:

Malacards categories (disease lists): (See all malacards categories)
Anatomical: Neuronal diseases


Aliases & Descriptions:

alcoholic neuropathy 9 11 46 63
alcohol-related polyneuropathy 9
alcoholic polyneuropathy 9


External Ids:

Disease Ontology9 DOID:14183
ICD9CM28 357.5
NCIt41 C26926
MeSH36 D020269
ICD1026 G62.1

Related Diseases for Alcoholic Neuropathy

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Sources:
18GeneCards, 19GeneDecks
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Diseases related to Alcoholic Neuropathy via text searches within MalaCards or GeneCards/GeneDecks gene sharing:

idRelated DiseaseScoreTop Affiliating Genes
1neuropathy10.8
2polyneuropathy10.0
3esophagitis10.0

Symptoms for Alcoholic Neuropathy

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Drugs & Therapeutics for Alcoholic Neuropathy

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Sources:
6CenterWatch, 43NIH Clinical Center, 7ClinicalTrials, 63UMLS, 42NDF-RT
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Approved drugs:

Search CenterWatch for Alcoholic Neuropathy

Drug clinical trials:

Search ClinicalTrials for Alcoholic Neuropathy

Search NIH Clinical Center for Alcoholic Neuropathy

Search CenterWatch for Alcoholic Neuropathy

Inferred drug relations via UMLS63/NDF-RT42:

Genetic Tests for Alcoholic Neuropathy

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Anatomical Context for Alcoholic Neuropathy

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34MalaCards
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MalaCards organs/tissues related to Alcoholic Neuropathy:

34
Liver, Skin

Animal Models for Alcoholic Neuropathy or affiliated genes

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38MGI
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MGI Mouse Phenotypes related to Alcoholic Neuropathy:

38
idDescriptionMGI Source AccessionScoreTop Affiliating Genes
1MP:00053899.1ALDH2, SPTLC1

Publications for Alcoholic Neuropathy

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53PubMed
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Articles related to Alcoholic Neuropathy:

(show all 41)
idTitleAuthorsYear
1
Evaluation of ameliorative effect of quercetin in experimental model of alcoholic neuropathy in rats. (22349996)
2012
2
Therapeutic role of curcumin in prevention of biochemical and behavioral aberration induced by alcoholic neuropathy in laboratory animals. (22281447)
2012
3
Electrophysiological and behavioral changes by phosphodiesterase 4 inhibitor in a rat model of alcoholic neuropathy. (22993675)
2012
4
Alcoholic neuropathy: possible mechanisms and future treatment possibilities. (21988193)
2012
5
Amelioration of functional, biochemical and molecular deficits by epigallocatechin gallate in experimental model of alcoholic neuropathy. (20699198)
2011
6
Tocotrienol ameliorates behavioral and biochemical alterations in the rat model of alcoholic neuropathy. (19541419)
2009
7
Alcohol-induced stress in painful alcoholic neuropathy. (18093169)
2008
8
Impact of cytokines on the pathomechanism of diabetic and alcoholic neuropathies. (17594598)
2007
9
Alcoholic neuropathy. (16969158)
2006
10
Resolution of alcoholic neuropathy following liver transplantation. (15558589)
2004
11
Alcoholic neuropathy is clinicopathologically distinct from thiamine-deficiency neuropathy. (12838517)
2003
12
Pathogenesis of alcoholic neuropathy. (12061083)
2002
13
Key role for the epsilon isoform of protein kinase C in painful alcoholic neuropathy in the rat. (11069970)
2000
14
Changes in sympathetic and parasympathetic function in alcoholic neuropathy. (9549310)
1998
15
Mexiletine for painful alcoholic neuropathy. (7549147)
1995
16
Sympathetic dysfunction mediating cardiovascular regulation in alcoholic neuropathy. (7926889)
1994
17
Comparison of sympathetic sudomotor and skin responses in alcoholic neuropathy. (8455654)
1993
18
Acute or subacute alcoholic neuropathy mimicking Guillain-BarrAc syndrome. (2401897)
1990
19
The haematic thiamine level in the course of alcoholic neuropathy. (3032641)
1987
20
The primary role of the Erb's point--axilla segment in median and ulnar motor nerve conduction determinations in alcoholic neuropathy. (3011999)
1986
21
Sympathetic vasoconstrictor nerve function in alcoholic neuropathy. (6540153)
1984
22
Alcoholic neuropathy associated with the eighth cranial nerve. (6867249)
1983
23
Alcoholic neuropathy and hepatopathy in mice. An experimental study. (6303042)
1983
24
Drinking habits and peripheral alcoholic neuropathy. (6278809)
1982
25
Alcohol, nutrition, and the nervous system. Alcoholic neuropathy. (6292675)
1982
26
Eighth nerve alcoholic neuropathy: a case report with light and electron microscopic findings. (7252342)
1981
27
Quantitative electrophysiological study of alcoholic neuropathy. (7420094)
1980
28
Animal models of alcoholic neuropathy: morphologic, electrophysiologic, and biochemical findings. (232540)
1979
29
Experimental alcoholic neuropathy in the rat: histological and electrophysiological study on the myoneural junctions and the peripheral nerves. (205081)
1978
30
Respective importance of different electrophysiological parameters in alcoholic neuropathy. (199711)
1977
31
Correlation of electrophysiological and quantitative histological findings in the sural nerve of man. Studies on alcoholic neuropathy. (72812)
1977
32
Alcoholic neuropathy. An electron-microscopic study. (169325)
1975
33
The sympathetic nervous system in alcoholic neuropathy. A clinical and pathological study. (171025)
1975
34
Electrophysiological evidence for a distal lesion in alcoholic neuropathy. (4343480)
1972
35
Pathogenesis of diabetic and alcoholic neuropathy. (5546239)
1971
36
Alcoholic neuropathy. (4328432)
1970
37
Alcoholic neuropathy. An electrophysiological and histological study. (4315536)
1970
38
Deterioration of esophageal peristalsis in patients with alcoholic neuropathy. (4298673)
1968
39
Alcoholic neuropathy. Its characteristic picture and variants viewed in the light of electromyography. (13766774)
1961
40
ALCOHOLIC neuropathy. (13050905)
1953
41
Alcoholic neuropathy and Laennec's cirrhosis. (15412051)
1950

Variations for Alcoholic Neuropathy

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Expression for genes affiliated with Alcoholic Neuropathy

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Sources:
2BioGPS, 16Gene Expression Omnibus DataSets
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Expression patterns in normal tissues for genes affiliated with Alcoholic Neuropathy

Search GEO for disease gene expression data for Alcoholic Neuropathy.

Pathways for genes affiliated with Alcoholic Neuropathy

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51PathCards, 56Reactome, 31KEGG
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Pathways related to Alcoholic Neuropathy according to GeneCards/GeneDecks:

idSuper pathways (with members indented)ScoreTop Affiliating Genes
1
Show member pathways
9.1ALDH2, SPTLC1

Compounds for genes affiliated with Alcoholic Neuropathy

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Sources:
46Novoseek, 30IUPHAR, 25HMDB, 12DrugBank
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Compounds related to Alcoholic Neuropathy according to GeneCards/GeneDecks:

idCompoundScoreTop Affiliating Genes
1cholesterol46 30 25 1212.1ALDH2, SPTLC1

GO Terms for genes affiliated with Alcoholic Neuropathy

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Sources:
17Gene Ontology
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Biological processes related to Alcoholic Neuropathy according to GeneCards/GeneDecks:

idNameGO IDScoreTop Affiliating Genes
1small molecule metabolic processGO:0442819.1ALDH2, SPTLC1

Products for genes affiliated with Alcoholic Neuropathy

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  • Antibodies
  • Proteins
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  • Antibodies

Sources for Alcoholic Neuropathy

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4CDC
14ExPASy
15FMA
23GTR
24HGMD
25HMDB
26ICD10
27ICD10 via Orphanet
28ICD9CM
30IUPHAR
31KEGG
36MeSH
37MESH via Orphanet
38MGI
41NCIt
42NDF-RT
45NINDS
46Novoseek
48OMIM
49OMIM via Orphanet
53PubMed
54QIAGEN
60SNOMED-CT via Orphanet
63UMLS
64UMLS via Orphanet