MCID: ALC005
MIFTS: 36

Alcoholic Pancreatitis

Categories: Endocrine diseases

Aliases & Classifications for Alcoholic Pancreatitis

MalaCards integrated aliases for Alcoholic Pancreatitis:

Name: Alcoholic Pancreatitis 12 14
Pancreatitis, Alcoholic 42 69
Pancreatitis Alcoholic 52

Classifications:



External Ids:

Disease Ontology 12 DOID:4988
MeSH 42 D019512
SNOMED-CT 64 445507008
UMLS 69 C0376670

Summaries for Alcoholic Pancreatitis

MalaCards based summary : Alcoholic Pancreatitis, also known as pancreatitis, alcoholic, is related to tropical calcific pancreatitis and pancreatitis. An important gene associated with Alcoholic Pancreatitis is SPINK1 (Serine Peptidase Inhibitor, Kazal Type 1), and among its related pathways/superpathways are superpathway of tryptophan utilization and Vitamin A and Carotenoid Metabolism. The drugs Octreotide and Dexmedetomidine have been mentioned in the context of this disorder. Affiliated tissues include pancreas, liver and bone.

Related Diseases for Alcoholic Pancreatitis

Diseases related to Alcoholic Pancreatitis via text searches within MalaCards or GeneCards Suite gene sharing:

(show top 50) (show all 55)
id Related Disease Score Top Affiliating Genes
1 tropical calcific pancreatitis 28.0 ADH1B ALDH2 CCK CFTR LPL PRSS1
2 pancreatitis 10.7
3 autoimmune retinopathy 10.5 CFTR PRSS1
4 netherton syndrome 10.4 PRSS1 SPINK1
5 lethal hydranencephaly-diaphragmatic hernia syndrome 10.3 ADH1B CYP2E1
6 mody, type iv 10.1 CFTR SCT SPINK1
7 subleukemic leukemia 10.0 ALDH2 CYP2E1
8 recurrent acute pancreatitis 10.0
9 alcohol-related neurodevelopmental disorder 10.0 ADH1B ALDH2
10 hyperparathyroidism, familial primary 9.9 SCT SPINK1
11 pontocerebellar hypoplasia 9.8 CCK CFTR
12 gastrointestinal adenoma 9.8 CCK SCT
13 duodenitis 9.8
14 tamoxifen-related endometrial lesion 9.8 CCK SCT
15 alcoholic liver cirrhosis 9.8 ALDH2 CYP2E1
16 bile duct cystadenocarcinoma 9.7 CCK SCT
17 hepatitis 9.7
18 liver disease 9.7
19 iris mixed cell melanoma 9.7 CCK SCT
20 alpha 1-antitrypsin deficiency 9.7 ADH1B ALDH2 CYP2E1
21 congenital bilateral absence of vas deferens 9.7 CFTR PRSS1 SCT SPINK1
22 male reproductive system disease 9.7 CCK SCT
23 cystic fibrosis 9.6
24 pancreatic cancer 9.6
25 alcohol abuse 9.6
26 liver cirrhosis 9.6
27 gastroduodenitis 9.6
28 lymphedema 9.6 ADH1B ALDH2 CYP2E1
29 fecal incontinence 9.5 CCK CFTR SCT
30 lactose intolerance 9.5 CCK CFTR SCT
31 tricuspid valve stenosis 9.5 CCK PRSS1 SCT
32 allergic urticaria 9.5 CCK PRSS1 SCT
33 retinal vascular occlusion 9.5 CCK SCT
34 obesity 9.5
35 alcohol dependence 9.5
36 hepatitis b 9.5
37 thrombosis 9.5
38 parotitis 9.5
39 pericardial effusion 9.5
40 duodenal ulcer 9.5
41 thrombophilia 9.5
42 acute pancreatitis 9.5
43 adenocarcinoma 9.5
44 mediastinitis 9.5
45 peritonitis 9.5
46 agenesis of the dorsal pancreas 9.5
47 measles 9.5 ALDH2 CYP2E1
48 cirrhotic cardiomyopathy 9.4 CFTR LPL PRSS1 SCT SPINK1
49 personality disorder 9.3 ADH1B ALDH2 CCK
50 chondroma 9.2 CCK PRSS1 SCT SPINK1

Graphical network of the top 20 diseases related to Alcoholic Pancreatitis:



Diseases related to Alcoholic Pancreatitis

Symptoms & Phenotypes for Alcoholic Pancreatitis

Drugs & Therapeutics for Alcoholic Pancreatitis

Drugs for Alcoholic Pancreatitis (from DrugBank, HMDB, Dgidb, PharmGKB, IUPHAR, NovoSeek, BitterDB):

(show top 50) (show all 62)
id Name Status Phase Clinical Trials Cas Number PubChem Id
1
Octreotide Approved, Investigational Phase 4 83150-76-9 383414 6400441
2
Dexmedetomidine Approved, Vet_approved Phase 4 76631-46-4, 113775-47-6 68602 5311068 56032
3
Propofol Approved, Investigational, Vet_approved Phase 4 2078-54-8 4943
4
Somatostatin Approved Phase 4 38916-34-6, 51110-01-1 53481605
5 Gastrointestinal Agents Phase 4,Phase 3,Phase 2
6 Hormone Antagonists Phase 4,Phase 3,Phase 2
7 Hormones Phase 4,Phase 3,Phase 2
8 Hormones, Hormone Substitutes, and Hormone Antagonists Phase 4,Phase 3,Phase 2
9 Peripheral Nervous System Agents Phase 4,Phase 3,Phase 2
10 Antineoplastic Agents, Hormonal Phase 4,Phase 3,Phase 2
11 Analgesics Phase 4
12 Central Nervous System Depressants Phase 4
13 Adrenergic Agents Phase 4
14 Adrenergic Agonists Phase 4
15 Adrenergic alpha-2 Receptor Agonists Phase 4
16 Adrenergic alpha-Agonists Phase 4
17 Neurotransmitter Agents Phase 4
18 Analgesics, Non-Narcotic Phase 4
19 Hypnotics and Sedatives Phase 4
20
Pentoxifylline Approved, Investigational Phase 3,Early Phase 1 6493-05-6 4740
21
Prednisolone Approved, Vet_approved Phase 3,Phase 2 50-24-8 5755
22
Methylprednisolone Approved, Vet_approved Phase 3,Phase 2 83-43-2 6741
23
Adenosine Approved, Investigational Phase 3 58-61-7 60961
24
Terlipressin Approved, Investigational Phase 3 14636-12-5 72081
25 Prednisolone acetate Phase 3,Phase 2
26 glucocorticoids Phase 3,Phase 2
27 Methylprednisolone acetate Phase 3,Phase 2
28 Methylprednisolone Hemisuccinate Phase 3,Phase 2
29 Neuroprotective Agents Phase 3,Phase 2
30 Vasodilator Agents Phase 3,Early Phase 1
31 Phosphodiesterase Inhibitors Phase 3,Early Phase 1
32 Platelet Aggregation Inhibitors Phase 3,Early Phase 1
33 Prednisolone hemisuccinate Phase 3,Phase 2
34 Prednisolone phosphate Phase 3,Phase 2
35 Anti-Inflammatory Agents Phase 3,Phase 2
36 Antiemetics Phase 3,Phase 2
37 Protective Agents Phase 3,Phase 2,Early Phase 1
38 Radiation-Protective Agents Phase 3,Early Phase 1
39 Autonomic Agents Phase 3,Phase 2
40 Antioxidants Phase 3,Early Phase 1
41 Micronutrients Phase 3
42 Trace Elements Phase 3
43 Vitamins Phase 3
44 diuretics Phase 3
45 Natriuretic Agents Phase 3
46 Vasoconstrictor Agents Phase 3
47 Anti-Bacterial Agents Phase 3
48 Anti-Infective Agents Phase 3
49 Antihypertensive Agents Phase 3
50 Antibiotics, Antitubercular Phase 3

Interventional clinical trials:

(show all 16)

id Name Status NCT ID Phase Drugs
1 Dexmedetomidine Versus Placebo in Endoscopic Retrograde Cholangiopancreatography (ERCP) Sedation Completed NCT01070680 Phase 4 Precedex;sodium chlorid 0,9%
2 Somatostatin, Octreotide, Pentoxyfilline in the Prevention of Post-ERCP Pancreatitis and Molecular Markers Completed NCT00222092 Phase 4
3 Short-term Survival in Patients With Severe Alcoholic Hepatitis Treated With Steroid Versus Pentoxifylline Unknown status NCT01455337 Phase 3 pentoxifylline;Prednisolone
4 Pentoxifylline Treatment in Acute Pancreatitis (AP) Enrolling by invitation NCT02487225 Phase 3 Pentoxifylline;Placebo
5 Comparison of Bovine Colostrum Versus Placebo in Treatment of Severe Alcoholic Hepatitis: A Randomized Double Blind Controlled Trial Not yet recruiting NCT02473341 Phase 3 Bovine Colostrum;Placebo
6 Efficacy of Combination Therapy of Glucocorticoids and Bovine Colostrum in Treatment of Severe Alcoholic Hepatitis. Completed NCT02265328 Phase 2
7 Recurrence of Acute Alcoholic Pancreatitis Completed NCT00523874
8 Decrease of Recurrent Pancreatitis Completed NCT00534534
9 Helicobacter Pylori and Acute Alcohol Induced Pancreatitis Completed NCT00490386
10 Pentoxifylline Treatment of Acute Pancreatitis Completed NCT01292005 Early Phase 1 Pentoxifylline;Placebo
11 CT Pancreas Perfusion Completed NCT00588367
12 Surgical Outcome and Differences on Histopathology in Patients With Alcoholic & Non Alcoholic Chronic Pancreatitis Completed NCT02048267
13 Moderate Versus Aggressive Fluids for Acute Pancreatitis Completed NCT01761539
14 The Effect of Vitamin D Substitution on the Development of Chronic Pancreatitis Recruiting NCT02965898
15 ERCP-induced and Non-ERCP Induced Acute Pancreatitis: Two Distinct Clinical and Immunological Entities? Enrolling by invitation NCT02602574
16 Albumindialysis in Acute Pancreatitis Suspended NCT00483912

Search NIH Clinical Center for Alcoholic Pancreatitis

Cochrane evidence based reviews: pancreatitis, alcoholic

Genetic Tests for Alcoholic Pancreatitis

Anatomical Context for Alcoholic Pancreatitis

MalaCards organs/tissues related to Alcoholic Pancreatitis:

39
Pancreas, Liver, Bone, Testes, Spinal Cord, Skin

Publications for Alcoholic Pancreatitis

Articles related to Alcoholic Pancreatitis:

(show top 50) (show all 257)
id Title Authors Year
1
Severity and outcomes of acute alcoholic pancreatitis in cannabis users. ( 28815220 )
2017
2
The Long-term Prospective Follow-up of Pancreatic Function After the First Episode of Acute Alcoholic Pancreatitis: Recurrence Predisposes One to Pancreatic Dysfunction and Pancreatogenic Diabetes. ( 28060789 )
2017
3
The lifestyle influence on alcoholic pancreatitis versus alcoholic liver disease: a case-control study. ( 28830264 )
2017
4
The Intensity of Brief Interventions in Patients with Acute Alcoholic Pancreatitis Should be Increased, Especially in Young Patients with Heavy Alcohol Consumption. ( 28419179 )
2017
5
Genetic Contribution to Alcohol Dependence: Investigation of a Heterogeneous German Sample of Individuals with Alcohol Dependence, Chronic Alcoholic Pancreatitis, and Alcohol-Related Cirrhosis. ( 28714907 )
2017
6
Agenesis of the dorsal pancreas associated with mucinous cysts and chronic calcific non-alcoholic pancreatitis. ( 28247770 )
2017
7
Alcoholic pancreatitis: New insights into the pathogenesis and treatment. ( 26909228 )
2016
8
Purtscher-like retinopathy in acute alcoholic pancreatitis. ( 27433040 )
2016
9
Genetically Determined Chronic Pancreatitis but not Alcoholic Pancreatitis Is a Strong Risk Factor for Pancreatic Cancer. ( 27518468 )
2016
10
Purtscher's-like retinopathy in acute alcoholic pancreatitis. ( 27628016 )
2016
11
Pharmacological attenuation of chronic alcoholic pancreatitis induced hypersensitivity in rats. ( 25624717 )
2015
12
Alcoholic Pancreatitis Masquerading as Preeclampsia. ( 26375717 )
2015
13
Elizabethkingia miricola bacteriemia in a young woman with acute alcoholic pancreatitis. ( 26337359 )
2015
14
Polymorphism of Alcohol Metabolizing Gene ADH3 Predisposes to Development of Alcoholic Pancreatitis in North Indian Population. ( 26734614 )
2015
15
Hemosuccus pancreaticus caused by rupture of a splenic artery pseudoaneurysm complicating chronic alcoholic pancreatitis: an uncommon cause of gastrointestinal bleeding. ( 26712055 )
2015
16
Pancreatic morphological changes in long-term follow-up after initial episode of acute alcoholic pancreatitis. ( 24002755 )
2014
17
Alcoholic pancreatitis: A tale of spirits and bacteria. ( 24891979 )
2014
18
Is alcoholic pancreatitis associated with enteroviral infection? ( 23840120 )
2013
19
Sex and age differences in alcoholic pancreatitis in Japan: a multicenter nationwide survey. ( 23508016 )
2013
20
Goal-related outcome after acute alcohol-pancreatitis -- a two-year follow-up study. ( 24018221 )
2013
21
Should pancreatectomy with islet cell autotransplantation in patients with chronic alcoholic pancreatitis be abandoned? ( 23521936 )
2013
22
Effects of oxidative alcohol metabolism on the mitochondrial permeability transition pore and necrosis in a mouse model of alcoholic pancreatitis. ( 23103769 )
2013
23
Necro-inflammatory response of pancreatic acinar cells in the pathogenesis of acute alcoholic pancreatitis. ( 24091659 )
2013
24
Alcoholic pancreatitis and midgut malrotation. ( 22880504 )
2012
25
Smoking and the course of recurrent acute and chronic alcoholic pancreatitis: a dose-dependent relationship. ( 23086245 )
2012
26
Low plasma antibodies specific for phosphatidylethanol in alcohol abusers and patients with alcoholic pancreatitis. ( 21309928 )
2012
27
Extrahepatic portal venous system thrombosis in recurrent acute and chronic alcoholic pancreatitis is caused by local inflammation and not thrombophilia. ( 22825367 )
2012
28
Stellate cell activation in tropical calcific pancreatitis compared to alcoholic pancreatitis, adenocarcinoma of pancreas and normal pancreas. ( 22797393 )
2012
29
Serum proinflammatory cytokine levels and white blood cell differential count in patients with different degrees of severity of acute alcoholic pancreatitis. ( 22763297 )
2012
30
Investigating the pathobiology of alcoholic pancreatitis. ( 21284675 )
2011
31
Recent advances in the epidemiology of alcoholic pancreatitis. ( 21243451 )
2011
32
Anthropometric measurements of nutritional status in chronic pancreatitis in India: comparison of tropical and alcoholic pancreatitis. ( 21509539 )
2011
33
Alcoholic pancreatitis complicated by an intra-abdominal abscess. ( 21443884 )
2011
34
Electronic clinical challenges and images in GI. A simple case of alcoholic pancreatitis. ( 20347040 )
2010
35
Effects of gadolinium chloride and glycine on hepatic and pancreatic tissue damage in alcoholic pancreatitis. ( 19924020 )
2010
36
Alcoholic pancreatitis: lessons from the liver. ( 20238397 )
2010
37
Fatty acid composition of plasma lipid classes in chronic alcoholic pancreatitis. ( 20980776 )
2010
38
Mechanisms of alcoholic pancreatitis. ( 21091991 )
2010
39
Association analyses of genetic polymorphisms of GSTM1, GSTT1, NQO1, NAT2, LPL, PRSS1, PSTI, and CFTR with chronic alcoholic pancreatitis in Japan. ( 18986377 )
2010
40
Beer and its non-alcoholic compounds: role in pancreatic exocrine secretion, alcoholic pancreatitis and pancreatic carcinoma. ( 20617020 )
2010
41
Pancreas: alcoholic pancreatitis--it's the alcohol, stupid. ( 19494819 )
2009
42
Ascites with Strongyloides stercoralis in a patient with acute alcoholic pancreatitis and liver cirrhosis. ( 19795035 )
2009
43
Alcoholic pancreatitis: pathogenesis, incidence and treatment with special reference to the associated pain. ( 20049222 )
2009
44
New insights into alcoholic pancreatitis and pancreatic cancer. ( 19799699 )
2009
45
Striving for abstinence in alcoholic pancreatitis: act of humanity, economic necessity, or flogging a dead horse after all? ( 19171144 )
2009
46
Pancreatic damage after the first episode of acute alcoholic pancreatitis and its association with the later recurrence rate. ( 19407478 )
2009
47
Endotoxin as a trigger of alcoholic pancreatitis. ( 18242233 )
2008
48
Association analysis among polymorphisms of the various genes and chronic alcoholic pancreatitis. ( 18336668 )
2008
49
A novel SPINK1 gene mutation, c.206C>T, in a Thai patient with chronic alcoholic pancreatitis. ( 18182741 )
2008
50
Morphological and functional evaluation of the pancreatic duct with secretin-stimulated magnetic resonance cholangiopancreatography in alcoholic pancreatitis patients. ( 18470615 )
2008

Variations for Alcoholic Pancreatitis

Expression for Alcoholic Pancreatitis

Search GEO for disease gene expression data for Alcoholic Pancreatitis.

Pathways for Alcoholic Pancreatitis

GO Terms for Alcoholic Pancreatitis

Cellular components related to Alcoholic Pancreatitis according to GeneCards Suite gene sharing:

id Name GO ID Score Top Affiliating Genes
1 extracellular exosome GO:0070062 9.43 ALDH2 CFTR LPL NQO2 PRSS1 SPINK1
2 extracellular space GO:0005615 9.02 CCK LPL PRSS1 SCT SPINK1

Biological processes related to Alcoholic Pancreatitis according to GeneCards Suite gene sharing:

id Name GO ID Score Top Affiliating Genes
1 oxidation-reduction process GO:0055114 9.46 ADH1B ALDH2 CYP2E1 NQO2
2 triglyceride metabolic process GO:0006641 8.96 CYP2E1 LPL
3 ethanol oxidation GO:0006069 8.62 ADH1B ALDH2

Molecular functions related to Alcoholic Pancreatitis according to GeneCards Suite gene sharing:

id Name GO ID Score Top Affiliating Genes
1 oxidoreductase activity GO:0016491 8.92 ADH1B ALDH2 CYP2E1 NQO2

Sources for Alcoholic Pancreatitis

3 CDC
7 CNVD
9 Cosmic
10 dbSNP
11 DGIdb
16 ExPASy
18 FMA
28 GO
29 GTR
30 HGMD
31 HMDB
32 HPO
33 ICD10
34 ICD10 via Orphanet
35 ICD9CM
36 IUPHAR
37 KEGG
38 LifeMap
40 MedGen
42 MeSH
43 MESH via Orphanet
44 MGI
46 NCI
47 NCIt
48 NDF-RT
51 NINDS
52 Novoseek
54 OMIM
55 OMIM via Orphanet
59 PubMed
60 QIAGEN
65 SNOMED-CT via HPO
66 SNOMED-CT via Orphanet
67 TGDB
68 Tocris
69 UMLS
70 UMLS via Orphanet
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