MCID: ALC005
MIFTS: 39

Alcoholic Pancreatitis

Categories: Endocrine diseases

Aliases & Classifications for Alcoholic Pancreatitis

MalaCards integrated aliases for Alcoholic Pancreatitis:

Name: Alcoholic Pancreatitis 12 14
Pancreatitis, Alcoholic 41 69
Pancreatitis Alcoholic 51

Classifications:



External Ids:

Disease Ontology 12 DOID:4988
MeSH 41 D019512
SNOMED-CT 64 445507008
UMLS 69 C0376670

Summaries for Alcoholic Pancreatitis

MalaCards based summary : Alcoholic Pancreatitis, also known as pancreatitis, alcoholic, is related to tropical calcific pancreatitis and pancreatitis. An important gene associated with Alcoholic Pancreatitis is SPINK1 (Serine Peptidase Inhibitor, Kazal Type 1), and among its related pathways/superpathways are superpathway of tryptophan utilization and Glycerolipid metabolism. The drugs Dexmedetomidine and Propofol have been mentioned in the context of this disorder. Affiliated tissues include pancreas, liver and bone.

Related Diseases for Alcoholic Pancreatitis

Diseases related to Alcoholic Pancreatitis via text searches within MalaCards or GeneCards Suite gene sharing:

(show top 50) (show all 60)
# Related Disease Score Top Affiliating Genes
1 tropical calcific pancreatitis 32.3 PRSS1 SPINK1
2 pancreatitis 29.5 CCK CFTR LPL PRSS1 SCT SPINK1
3 recurrent acute pancreatitis 29.4 CFTR LPL PRSS1 SCT SPINK1
4 cystic fibrosis 29.2 CFTR PRSS1 SCT SPINK1
5 alcohol abuse 29.1 ALDH2 CYP2E1
6 liver cirrhosis 29.1 ADH1B ALDH2 CYP2E1
7 duodenal ulcer 28.8 CCK SCT
8 acute pancreatitis 28.4 CCK LPL SCT SPINK1
9 pancreatic cancer 28.4 CCK PRSS1 SCT SPINK1
10 alcohol dependence 28.0 ADH1B ALDH2 CCK CYP2E1
11 autoimmune pancreatitis 10.3 CFTR PRSS1
12 methanol poisoning 10.2 ADH1B CYP2E1
13 alcohol use disorder 10.1 ADH1B ALDH2
14 pancreatic agenesis 1 10.0 CFTR SCT SPINK1
15 sister chromatid exchange, frequency of 10.0 ALDH2 CYP2E1
16 fetal alcohol syndrome 9.9 ADH1B ALDH2
17 fibrosis of extraocular muscles, congenital, 1 9.9
18 duodenitis 9.9
19 hepatitis 9.8
20 liver disease 9.8
21 biliary dyskinesia 9.8 CCK SCT
22 duodenal disease 9.8 CCK SCT
23 duodenal gastrinoma 9.8 CCK SCT
24 duodenogastric reflux 9.7 CCK SCT
25 gallbladder disease 9.7 CCK CFTR
26 pancreatic cholera 9.7 CCK SCT
27 alcoholic liver cirrhosis 9.7 ADH1B ALDH2 CYP2E1
28 episodic pain syndrome, familial, 1 9.7
29 gastroduodenitis 9.7
30 steatorrhea 9.6 CCK CFTR SCT
31 exocrine pancreatic insufficiency 9.6 CCK CFTR SCT
32 pancreatic steatorrhea 9.6 CCK PRSS1 SCT
33 cataract 32, multiple types 9.6
34 complement hyperactivation, angiopathic thrombosis, and protein-losing enteropathy 9.6
35 body mass index quantitative trait locus 11 9.6
36 aging 9.6
37 gallbladder disease 1 9.6
38 body mass index quantitative trait locus 9 9.6
39 body mass index quantitative trait locus 8 9.6
40 body mass index quantitative trait locus 4 9.6
41 body mass index quantitative trait locus 10 9.6
42 body mass index quantitative trait locus 7 9.6
43 body mass index quantitative trait locus 12 9.6
44 body mass index quantitative trait locus 14 9.6
45 body mass index quantitative trait locus 18 9.6
46 hepatitis b 9.6
47 pancreas adenocarcinoma 9.6
48 thrombosis 9.6
49 parotitis 9.6
50 hemopericardium 9.6

Graphical network of the top 20 diseases related to Alcoholic Pancreatitis:



Diseases related to Alcoholic Pancreatitis

Symptoms & Phenotypes for Alcoholic Pancreatitis

Drugs & Therapeutics for Alcoholic Pancreatitis

Drugs for Alcoholic Pancreatitis (from DrugBank, HMDB, Dgidb, PharmGKB, IUPHAR, NovoSeek, BitterDB):

(show all 33)
# Name Status Phase Clinical Trials Cas Number PubChem Id
1
Dexmedetomidine Approved, Vet_approved Phase 4 76631-46-4, 113775-47-6 5311068 56032 68602
2
Propofol Approved, Investigational, Vet_approved Phase 4 2078-54-8 4943
3 Adrenergic Agents Phase 4
4 Adrenergic Agonists Phase 4
5 Adrenergic alpha-2 Receptor Agonists Phase 4
6 Adrenergic alpha-Agonists Phase 4
7 Analgesics Phase 4
8 Analgesics, Non-Narcotic Phase 4
9 Central Nervous System Depressants Phase 4
10 Hypnotics and Sedatives Phase 4
11 Neurotransmitter Agents Phase 4
12 Peripheral Nervous System Agents Phase 4
13
Adenosine Approved, Investigational Phase 3 58-61-7 60961
14
Pentoxifylline Approved, Investigational Phase 3,Early Phase 1 6493-05-6 4740
15 Antioxidants Phase 3,Early Phase 1
16 Phosphodiesterase Inhibitors Phase 3,Early Phase 1
17 Platelet Aggregation Inhibitors Phase 3,Early Phase 1
18 Protective Agents Phase 3,Early Phase 1
19 Radiation-Protective Agents Phase 3,Early Phase 1
20 Vasodilator Agents Phase 3,Early Phase 1
21
Ethanol Approved 64-17-5 702
22
Pancrelipase Approved, Investigational 53608-75-6
23
Ergocalciferol Approved, Nutraceutical 50-14-6 5280793
24
Vitamin D Approved, Nutraceutical, Vet_approved 1406-16-2
25 pancreatin
26 Pharmaceutical Solutions Not Applicable
27 Bone Density Conservation Agents
28 Ergocalciferols
29 Micronutrients
30 Trace Elements
31 Vitamins
32 Calciferol Nutraceutical
33 Vitamin D2 Nutraceutical

Interventional clinical trials:


# Name Status NCT ID Phase Drugs
1 Dexmedetomidine Versus Placebo in Endoscopic Retrograde Cholangiopancreatography (ERCP) Sedation Completed NCT01070680 Phase 4 Precedex;sodium chlorid 0,9%
2 Pentoxifylline Treatment in Acute Pancreatitis (AP) Completed NCT02487225 Phase 3 Pentoxifylline;Placebo
3 Recurrence of Acute Alcoholic Pancreatitis Completed NCT00523874
4 Decrease of Recurrent Pancreatitis Completed NCT00534534
5 Helicobacter Pylori and Acute Alcohol Induced Pancreatitis Completed NCT00490386
6 Pentoxifylline Treatment of Acute Pancreatitis Completed NCT01292005 Early Phase 1 Pentoxifylline;Placebo
7 CT Pancreas Perfusion Completed NCT00588367
8 Moderate Versus Aggressive Fluids for Acute Pancreatitis Completed NCT01761539 Not Applicable
9 The Effect of Vitamin D Substitution on the Development of Chronic Pancreatitis Recruiting NCT02965898
10 Albumindialysis in Acute Pancreatitis Suspended NCT00483912

Search NIH Clinical Center for Alcoholic Pancreatitis

Cochrane evidence based reviews: pancreatitis, alcoholic

Genetic Tests for Alcoholic Pancreatitis

Anatomical Context for Alcoholic Pancreatitis

MalaCards organs/tissues related to Alcoholic Pancreatitis:

38
Pancreas, Liver, Bone, Testes, Spinal Cord, Skin

Publications for Alcoholic Pancreatitis

Articles related to Alcoholic Pancreatitis:

(show top 50) (show all 257)
# Title Authors Year
1
Severity and outcomes of acute alcoholic pancreatitis in cannabis users. ( 28815220 )
2017
2
Agenesis of the dorsal pancreas associated with mucinous cysts and chronic calcific non-alcoholic pancreatitis. ( 28247770 )
2017
3
The Intensity of Brief Interventions in Patients with Acute Alcoholic Pancreatitis Should be Increased, Especially in Young Patients with Heavy Alcohol Consumption. ( 28419179 )
2017
4
Genetic Contribution to Alcohol Dependence: Investigation of a Heterogeneous German Sample of Individuals with Alcohol Dependence, Chronic Alcoholic Pancreatitis, and Alcohol-Related Cirrhosis. ( 28714907 )
2017
5
The lifestyle influence on alcoholic pancreatitis versus alcoholic liver disease: a case-control study. ( 28830264 )
2017
6
The Long-term Prospective Follow-up of Pancreatic Function After the First Episode of Acute Alcoholic Pancreatitis: Recurrence Predisposes One to Pancreatic Dysfunction and Pancreatogenic Diabetes. ( 28060789 )
2017
7
Purtscher-like retinopathy in acute alcoholic pancreatitis. ( 27433040 )
2016
8
Alcoholic pancreatitis: New insights into the pathogenesis and treatment. ( 26909228 )
2016
9
Purtscher's-like retinopathy in acute alcoholic pancreatitis. ( 27628016 )
2016
10
Genetically Determined Chronic Pancreatitis but not Alcoholic Pancreatitis Is a Strong Risk Factor for Pancreatic Cancer. ( 27518468 )
2016
11
Alcoholic Pancreatitis Masquerading as Preeclampsia. ( 26375717 )
2015
12
Hemosuccus pancreaticus caused by rupture of a splenic artery pseudoaneurysm complicating chronic alcoholic pancreatitis: an uncommon cause of gastrointestinal bleeding. ( 26712055 )
2015
13
Polymorphism of Alcohol Metabolizing Gene ADH3 Predisposes to Development of Alcoholic Pancreatitis in North Indian Population. ( 26734614 )
2015
14
Pharmacological attenuation of chronic alcoholic pancreatitis induced hypersensitivity in rats. ( 25624717 )
2015
15
Elizabethkingia miricola bacteriemia in a young woman with acute alcoholic pancreatitis. ( 26337359 )
2015
16
Pancreatic morphological changes in long-term follow-up after initial episode of acute alcoholic pancreatitis. ( 24002755 )
2014
17
Alcoholic pancreatitis: A tale of spirits and bacteria. ( 24891979 )
2014
18
Is alcoholic pancreatitis associated with enteroviral infection? ( 23840120 )
2013
19
Necro-inflammatory response of pancreatic acinar cells in the pathogenesis of acute alcoholic pancreatitis. ( 24091659 )
2013
20
Effects of oxidative alcohol metabolism on the mitochondrial permeability transition pore and necrosis in a mouse model of alcoholic pancreatitis. ( 23103769 )
2013
21
Should pancreatectomy with islet cell autotransplantation in patients with chronic alcoholic pancreatitis be abandoned? ( 23521936 )
2013
22
Goal-related outcome after acute alcohol-pancreatitis -- a two-year follow-up study. ( 24018221 )
2013
23
Sex and age differences in alcoholic pancreatitis in Japan: a multicenter nationwide survey. ( 23508016 )
2013
24
Stellate cell activation in tropical calcific pancreatitis compared to alcoholic pancreatitis, adenocarcinoma of pancreas and normal pancreas. ( 22797393 )
2012
25
Serum proinflammatory cytokine levels and white blood cell differential count in patients with different degrees of severity of acute alcoholic pancreatitis. ( 22763297 )
2012
26
Extrahepatic portal venous system thrombosis in recurrent acute and chronic alcoholic pancreatitis is caused by local inflammation and not thrombophilia. ( 22825367 )
2012
27
Alcoholic pancreatitis and midgut malrotation. ( 22880504 )
2012
28
Low plasma antibodies specific for phosphatidylethanol in alcohol abusers and patients with alcoholic pancreatitis. ( 21309928 )
2012
29
Smoking and the course of recurrent acute and chronic alcoholic pancreatitis: a dose-dependent relationship. ( 23086245 )
2012
30
Anthropometric measurements of nutritional status in chronic pancreatitis in India: comparison of tropical and alcoholic pancreatitis. ( 21509539 )
2011
31
Alcoholic pancreatitis complicated by an intra-abdominal abscess. ( 21443884 )
2011
32
Investigating the pathobiology of alcoholic pancreatitis. ( 21284675 )
2011
33
Recent advances in the epidemiology of alcoholic pancreatitis. ( 21243451 )
2011
34
Electronic clinical challenges and images in GI. A simple case of alcoholic pancreatitis. ( 20347040 )
2010
35
Association analyses of genetic polymorphisms of GSTM1, GSTT1, NQO1, NAT2, LPL, PRSS1, PSTI, and CFTR with chronic alcoholic pancreatitis in Japan. ( 18986377 )
2010
36
Beer and its non-alcoholic compounds: role in pancreatic exocrine secretion, alcoholic pancreatitis and pancreatic carcinoma. ( 20617020 )
2010
37
Fatty acid composition of plasma lipid classes in chronic alcoholic pancreatitis. ( 20980776 )
2010
38
Effects of gadolinium chloride and glycine on hepatic and pancreatic tissue damage in alcoholic pancreatitis. ( 19924020 )
2010
39
Mechanisms of alcoholic pancreatitis. ( 21091991 )
2010
40
Alcoholic pancreatitis: lessons from the liver. ( 20238397 )
2010
41
Striving for abstinence in alcoholic pancreatitis: act of humanity, economic necessity, or flogging a dead horse after all? ( 19171144 )
2009
42
New insights into alcoholic pancreatitis and pancreatic cancer. ( 19799699 )
2009
43
Pancreatic damage after the first episode of acute alcoholic pancreatitis and its association with the later recurrence rate. ( 19407478 )
2009
44
Pancreas: alcoholic pancreatitis--it's the alcohol, stupid. ( 19494819 )
2009
45
Alcoholic pancreatitis: pathogenesis, incidence and treatment with special reference to the associated pain. ( 20049222 )
2009
46
Ascites with Strongyloides stercoralis in a patient with acute alcoholic pancreatitis and liver cirrhosis. ( 19795035 )
2009
47
VAMP8 is the v-SNARE that mediates basolateral exocytosis in a mouse model of alcoholic pancreatitis. ( 18535671 )
2008
48
Endotoxin as a trigger of alcoholic pancreatitis. ( 18242233 )
2008
49
A novel SPINK1 gene mutation, c.206C>T, in a Thai patient with chronic alcoholic pancreatitis. ( 18182741 )
2008
50
Association analysis among polymorphisms of the various genes and chronic alcoholic pancreatitis. ( 18336668 )
2008

Variations for Alcoholic Pancreatitis

Expression for Alcoholic Pancreatitis

Search GEO for disease gene expression data for Alcoholic Pancreatitis.

Pathways for Alcoholic Pancreatitis

GO Terms for Alcoholic Pancreatitis

Cellular components related to Alcoholic Pancreatitis according to GeneCards Suite gene sharing:

# Name GO ID Score Top Affiliating Genes
1 extracellular exosome GO:0070062 9.43 ALDH2 CFTR LPL NQO2 PRSS1 SPINK1
2 extracellular space GO:0005615 9.02 CCK LPL PRSS1 SCT SPINK1

Biological processes related to Alcoholic Pancreatitis according to GeneCards Suite gene sharing:

# Name GO ID Score Top Affiliating Genes
1 oxidation-reduction process GO:0055114 9.56 ADH1B ALDH2 CYP2E1 NQO2
2 triglyceride metabolic process GO:0006641 9.16 CYP2E1 LPL
3 sperm capacitation GO:0048240 8.96 CFTR SPINK1
4 ethanol oxidation GO:0006069 8.62 ADH1B ALDH2

Molecular functions related to Alcoholic Pancreatitis according to GeneCards Suite gene sharing:

# Name GO ID Score Top Affiliating Genes
1 oxidoreductase activity GO:0016491 8.92 ADH1B ALDH2 CYP2E1 NQO2

Sources for Alcoholic Pancreatitis

3 CDC
7 CNVD
9 Cosmic
10 dbSNP
11 DGIdb
16 ExPASy
18 FMA
27 GO
28 GTR
29 HGMD
30 HMDB
31 HPO
32 ICD10
33 ICD10 via Orphanet
34 ICD9CM
35 IUPHAR
36 KEGG
37 LifeMap
39 MedGen
41 MeSH
42 MESH via Orphanet
43 MGI
45 NCI
46 NCIt
47 NDF-RT
50 NINDS
51 Novoseek
53 OMIM
54 OMIM via Orphanet
58 PubMed
60 QIAGEN
65 SNOMED-CT via HPO
66 SNOMED-CT via Orphanet
67 TGDB
68 Tocris
69 UMLS
70 UMLS via Orphanet
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