MCID: ALC005
MIFTS: 44

Alcoholic Pancreatitis malady

Endocrine category

Summaries for Alcoholic Pancreatitis

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33MalaCards
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MalaCards: Alcoholic Pancreatitis, also known as pancreatitis, alcoholic, is related to pancreatitis, chronic and acute pancreatitis. An important gene associated with Alcoholic Pancreatitis is SPINK1 (serine peptidase inhibitor, Kazal type 1), and among its related pathways are acetone degradation I (to methylglyoxal) and ethanol degradation II. The compounds acetone and epft have been mentioned in the context of this disorder. Affiliated tissues include skin, liver and spinal cord, and related mouse phenotypes are liver/biliary system and homeostasis/metabolism.

Aliases & Classifications for Alcoholic Pancreatitis

Sources:
8Disease Ontology, 10DISEASES, 45Novoseek, 61UMLS, 35MeSH
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Classifications:

Malacards categories (disease lists): (See all malacards categories)
Anatomical: Endocrine


Aliases & Descriptions:

alcoholic pancreatitis 8 10
pancreatitis, alcoholic 61
pancreatitis alcoholic 45


External Ids:

Disease Ontology8 DOID:4988
MeSH35 D019512

Related Diseases for Alcoholic Pancreatitis

Sources:
17GeneCards, 18GeneDecks
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Diseases related to Alcoholic Pancreatitis via text searches within MalaCards or GeneCards/GeneDecks gene sharing:

(show top 50)    (show all 87)
idRelated DiseaseScoreTop Affiliating Genes
1pancreatitis, chronic31.4KRT8, PNLIP, REG3A, CYP2E1, LIPF, PRSS1
2acute pancreatitis31.2CCK, ADH1B, SPINK1, TMPRSS15, PNLIP, REG3A
3recurrent acute pancreatitis30.4SPINK1, LPL, SCT
4hereditary pancreatitis30.2SPINK1, PRSS1
5alcoholic liver cirrhosis30.2ADH1B, NAT2, CYP2E1
6cystic fibrosis30.2SCT, LPL, PRSS1, REG3A, NAT2, PNLIP
7tropical calcific pancreatitis30.0SPINK1
8insulin resistance29.9CYP2E1, DBI, IAPP, LPL
9adenocarcinoma29.9CCK, SCT, PRSS1, IAPP, BAK1, NQO1
10alcohol abuse10.1
11duodenal ulcer10.0
12hepatitis c10.0
13papillary carcinoma10.0
14parotitis10.0
15alcoholic hepatitis10.0
16hepatitis a10.0
17thrombophilia10.0
18chronic pain10.0
19pancreatitis, idiopathic10.0
20venous thrombosis10.0
21hyperparathyroidism10.0SCT
22squamous cell carcinoma10.0ADH1B
23lung cancer10.0CYP2E1
24pancreatitis10.0PRSS1, SPINK1
25cholesterol ester storage disease10.0PNLIP
26esophageal cancer10.0CYP2E1, ADH1B
27myeloma10.0BAK1, PRSS1
28duodenogastric reflux10.0CCK
29celiac disease10.0CCK
30hypoglycemia10.0IAPP, SCT
31pancreatic steatorrhea10.0PNLIP, PRSS1
32gastritis10.0SCT, CCK
33oral cancer10.0GSTT1, CYP2E1
34exocrine pancreatic insufficiency10.0PNLIP, SCT, CCK
35leukoplakia10.0GSTT1, KRT8
36hepatoblastoma10.0NQO1, NQO2, CYP2E1
37brain cancer10.0NQO1, GSTT1
38motor neuron disease10.0GSTT1
39schizophrenia10.0CCK, SCT, NQO1, NQO2
40steatorrhea10.0CCK, SCT, PNLIP, TMPRSS15
41laryngeal carcinoma10.0BAK1, NAT2, GSTT1
42neuroendocrine tumor10.0CCK, SCT, KRT8
43fatty liver disease10.0LPL, DBI, CYP2E1
44pancreatic cancer10.0CCK, SCT, KRT8, SPINK1
45acute lymphoblastic leukemia, childhood10.0GSTT1, CYP2E1, NQO1
46cholangiocarcinoma10.0SCT, NAT2, PNLIP, KRT8
47nasopharynx carcinoma10.0GSTT1, NAT2, CYP2E1
48hepatitis10.0CYP2E1, NAT2, KRT8, GSTT1
49transitional cell carcinoma10.0NAT2, KRT8, SPINK1, GSTT1
50liver cirrhosis10.0ADH1B, KRT8, CYP2E1, SCT

Graphical network of the top 20 diseases related to Alcoholic Pancreatitis:



Diseases related to alcoholic pancreatitis

Clinical Features for Alcoholic Pancreatitis

Drugs & Therapeutics for Alcoholic Pancreatitis

Sources:
5CenterWatch, 42NIH Clinical Center, 6ClinicalTrials, 61UMLS, 41NDF-RT
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Approved drugs:

Search CenterWatch for Alcoholic Pancreatitis

Drug clinical trials:

Search ClinicalTrials for Alcoholic Pancreatitis

Search NIH Clinical Center for Alcoholic Pancreatitis

Search CenterWatch for Alcoholic Pancreatitis

Genetic Tests for Alcoholic Pancreatitis

Anatomical Context for Alcoholic Pancreatitis

Sources:
33MalaCards
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MalaCards organs/tissues related to Alcoholic Pancreatitis:

33
Skin, Liver, Spinal cord, Kidney, Pancreas, T cells, B cells, Pancreatic islet

Animal Models for Alcoholic Pancreatitis or affiliated genes

Sources:
37MGI, 28inGenious Targeting Laboratory
See all sources

MGI Mouse Phenotypes related to Alcoholic Pancreatitis:

37
idDescriptionMGI Source AccessionScoreTop Affiliating Genes
1MP:00053709.4KRT8, PNLIP, CYP2E1, NQO1, DBI, LPL
2MP:00053767.4GSTT1, CCK, SCT, LPL, STX4, IAPP

Publications for Alcoholic Pancreatitis

Sources:
51PubMed
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Articles related to Alcoholic Pancreatitis:

(show top 50)    (show all 288)
idTitleAuthorsYear
1
Pancreatic morphological changes in long-term follow-up after initial episode of acute alcoholic pancreatitis. (24002755)
2014
2
The number of tandem repeats in the carboxyl-ester lipase (CEL) gene as a risk factor in alcoholic and idiopathic chronic pancreatitis. (23395566)
2013
3
Alcoholic liver disease and pancreatitis: global health problems being addressed by the US National Institute on Alcohol Abuse and Alcoholism. (23855288)
2013
4
Biopsy-proven drug-induced tubulointerstitial nephritis in a patient with acute kidney injury and alcoholic severe acute pancreatitis. (23645698)
2013
5
Stellate cell activation in tropical calcific pancreatitis compared to alcoholic pancreatitis, adenocarcinoma of pancreas and normal pancreas. (22797393)
2012
6
Secular trends of fibrocalculous pancreatic diabetes and diabetes secondary to alcoholic chronic pancreatitis at a tertiary care diabetes centre in South India. (22406602)
2012
7
Smoking and the course of recurrent acute and chronic alcoholic pancreatitis: a dose-dependent relationship. (23086245)
2012
8
The prevalence of cationic trypsinogen (PRSS1) and serine protease inhibitor, Kazal type 1 (SPINK1) gene mutations in Polish patients with alcoholic and idiopathic chronic pancreatitis. (20676769)
2011
9
Irreversible exocrine pancreatic insufficiency in alcoholic rats without chronic pancreatitis after alcohol withdrawal. (20662806)
2010
10
Electronic clinical challenges and images in GI. A simple case of alcoholic pancreatitis. (20347040)
2010
11
Beer and its non-alcoholic compounds: role in pancreatic exocrine secretion, alcoholic pancreatitis and pancreatic carcinoma. (20617020)
2010
12
Alcoholic pancreatitis: pathogenesis, incidence and treatment with special reference to the associated pain. (20049222)
2009
13
Polymorphisms of the MCP-1 and HSP70-2 genes in Korean patients with alcoholic chronic pancreatitis. (17940904)
2008
14
Alcoholic pancreatitis: new pathogenetic insights. (18663346)
2008
15
Bacterial endotoxin: a trigger factor for alcoholic pancreatitis? Evidence from a novel, physiologically relevant animal model. (17919500)
2007
16
Duodenal diazepam-binding protein expression and plasma cholecystokinin after alcoholic pancreatitis. (17101560)
2006
17
CD14 promoter polymorphism in Chinese alcoholic patients with cirrhosis of liver and acute pancreatitis. (16273622)
2005
18
Alcoholic pancreatitis: is it a priori chronic disease? (15128063)
2004
19
Analysis of tumor necrosis factor-alpha, transforming growth factor-beta 1, interleukin-10, and interferon-gamma polymorphisms in patients with alcoholic chronic pancreatitis. (15066699)
2004
20
Genetic polymorphisms of alcohol-metabolizing enzymes and cytokines in patients with alcohol induced pancreatitis and alcoholic liver cirrhosis]. (15220553)
2004
21
Chronic alcoholic pancreatitis with pancreas divisum. (15309889)
2004
22
Do CFTR gene polymorphisms determine the susceptibility to alcoholic chronic pancreatitis? (15645635)
2004
23
Changes in indicators of external and internal secretion of the pancreas during treatment of chronic pancreatitis of alcoholic etiology with somatostatin analogs]. (12685392)
2003
24
Elevated fasting plasma level of islet amyloid polypeptide (IAPP) in chronic alcoholic pancreatitis (CAP). (12630035)
2003
25
Short note about a symposium on alcoholic pancreatitis. (12649569)
2003
26
Mechanisms of alcoholic pancreatitis. Proceedings of a conference. Chicago, Illinois, USA, November 2002. (14576487)
2003
27
Usefulness of carbohydrate-deficient transferrin and trypsin activity in the diagnosis of acute alcoholic pancreatitis. (11419828)
2001
28
Neurological damage and duodenopancreatic reflux in the pathogenesis of alcoholic pancreatitis. (10722028)
2000
29
Serum levels of cytokines in alcoholic liver cirrhosis and pancreatitis. (11059648)
2000
30
The pancreatitis-associated protein in hereditary and chronic alcoholic pancreatitis. (10505755)
1999
31
Genotypes of alcohol-metabolizing enzymes and the risk for alcoholic chronic pancreatitis in Japanese alcoholics. (8986224)
1996
32
Evaluation of hypotheses on pathogenesis of alcoholic pancreatitis. (8677923)
1996
33
Disappearance of a large mediastinal pseudocyst in a patient with chronic alcoholic pancreatitis after total parenteral nutrition. (7600145)
1995
34
Can the L/A ratio identify acute alcoholic pancreatitis?]. (7571983)
1995
35
Evaluation of etiological hypotheses and a study of early lesions in alcoholic pancreatitis. (8974356)
1994
36
Smoking and alcoholic pancreatitis. (8302794)
1993
37
Basal sphincter of Oddi pressure never elevated in alcoholic pancreatitis? (1587205)
1992
38
The role of acetaldehyde in the pathogenesis of acute alcoholic pancreatitis. (1720611)
1991
39
Alpha 1 antitrypsin phenotypes and alcoholic pancreatitis. (1885078)
1991
40
Histopathologic and immunohistochemical studies on alcoholic pancreatitis and chronic obstructive pancreatitis: special emphasis on ductal obstruction and genesis of pancreatitis. (2178399)
1990
41
On the pathogenesis of chronic alcoholic pancreatitis from the viewpoint of experimental results in rats. (3681035)
1987
42
Acute (nonprogressive) alcoholic pancreatitis: prospective longitudinal study of 144 patients with recurrent alcoholic pancreatitis. (3575305)
1986
43
Duodenal total and ionised calcium secretion in normal subjects, chronic alcoholics, and patients with various stages of chronic alcoholic pancreatitis. (6745727)
1984
44
The role of pancreatobiliary duct anatomy in the etiology of alcoholic pancreatitis. (6501827)
1984
45
Resection for chronic alcoholic pancreatitis. (7225966)
1981
46
Cyclic AMP as a determinant of the course of acute alcoholic pancreatitis. (175517)
1975
47
Pancreatitis. The role of vagotomy, antrectomy, and Billroth II gastroenterostomy in the treatment of alcoholic pancreatitis. (5042804)
1972
48
A comparison of alcoholic pancreatitis in rat and man. (4329553)
1971
49
Experimental acute alcoholic pancreatitis. (5264055)
1970
50
The clinical varieties of alcoholic pancreatitis in the South Western Cape--a review of 206 cases. (5854981)
1965

Genetic Variations for Alcoholic Pancreatitis

Expression for genes affiliated with Alcoholic Pancreatitis

Sources:
1BioGPS, 15Gene Expression Omnibus DataSets
See all sources
Expression patterns in normal tissues for genes affiliated with Alcoholic Pancreatitis

Search GEO for disease gene expression data for Alcoholic Pancreatitis.

Pathways for genes affiliated with Alcoholic Pancreatitis

Sources:
38NCBI BioSystems Database, 50PharmGKB, 12EMD Millipore, 30KEGG, 54Reactome
See all sources

Compounds for genes affiliated with Alcoholic Pancreatitis

Sources:
45Novoseek, 29IUPHAR, 50PharmGKB, 11DrugBank, 24HMDB, 60Tocris Bioscience, 2BitterDB
See all sources

Compounds related to Alcoholic Pancreatitis according to GeneCards/GeneDecks:

(show top 50)    (show all 121)
idCompoundScoreTop Affiliating Genes
1acetone4510.5GSTT1
2epft4510.4SCT, CCK
3trans,trans-muconic acid4510.4GSTT1, CYP2E1, NQO1
4s-phenylmercapturic acid4510.4GSTT1, CYP2E1, NQO1
5styrene4510.3GSTT1, NAT2, CYP2E1
6trichloroethylene4510.3GSTT1, NAT2, CYP2E1
7omeprazole45 29 50 11 2414.3CCK, SCT, CYP2E1, NAT2
8clofibrate45 29 1112.3CYP2E1, NQO1, LPL
9hydroquinone45 2411.3NQO1, NQO2, CYP2E1
10isoniazid50 45 1112.3CYP2E1, NAT2, GSTT1
11chlorzoxazone45 29 1112.2NAT2, CYP2E1, NQO1
12rsai4510.2CYP2E1, NAT2, ADH1B, GSTT1
13pristimerin6010.2LPL, LIPF, PNLIP
14gsk 264220a6010.2LPL, LIPF, PNLIP
15mspi4510.2CYP2E1, NAT2, ADH1B, GSTT1
161-hydroxypyrene4510.2NQO1, CYP2E1, NAT2, GSTT1
17jzl 1846010.2LPL, LIPF, PNLIP
18benzene4510.2NQO1, CYP2E1, NAT2, GSTT1
19gsts4510.2NQO1, CYP2E1, NAT2, GSTT1
20beta-naphthoflavone45 1111.2NQO1, NQO2, CYP2E1
21benzo(a)pyrene4510.2NQO1, NQO2, NAT2, GSTT1
22paraoxon45 2411.2LPL, CYP2E1, NAT2, PNLIP
23epoxide4510.2GSTT1, NAT2, CYP2E1, NQO1
24quinone45 2411.1NQO1, NQO2, KRT8, GSTT1
25drugs for treatment of tuberculosis5010.1GSTT1, NAT2
26orlistat45 60 1112.1CCK, LPL, LIPF, PNLIP
27acetaminophen45 2 50 11 2414.1CCK, IAPP, NQO1, CYP2E1, NAT2
28hydrocarbons4510.1NQO1, NAT2, GSTT1
29taurocholate4510.0CCK, SCT, LPL, PNLIP, TMPRSS15
30olestra4510.0PNLIP, CCK
31tolbutamide45 50 29 1113.0NAT2, CYP2E1, NQO1
32glycerol45 11 2411.9CCK, LPL, CYP2E1, PNLIP, ADH1B
33caffeine45 50 29 2 11 2414.9CCK, LPL, CYP2E1, NAT2
34resveratrol45 60 11 2412.9CYP2E1, NQO2, NQO1, BAK1
35dopamine45 29 11 2412.9CCK, SCT, IAPP, NQO1, CYP2E1, ADH1B
36polysaccharide459.8CCK, LPL, PRSS1, LIPF, TMPRSS15
37norepinephrine45 11 2411.8CCK, SCT, LPL, IAPP, NQO1, PNLIP
38ethanol45 50 11 2412.8SCT, CYP2E1, PNLIP, KRT8, ADH1B, GSTT1
39creatinine459.8IAPP, NQO1, CYP2E1, KRT8, SPINK1, GSTT1
40trypsinogen459.8SPINK1, CCK, SCT, PRSS1, REG3A, PNLIP
41testosterone45 60 11 2412.7CCK, SCT, LPL, IAPP, NQO1, CYP2E1
42arginine459.7CCK, SCT, PRSS1, IAPP, NQO1, TMPRSS15
43dexamethasone45 50 29 1112.6CCK, LPL, IAPP, BAK1, NQO1, CYP2E1
44cholesterol45 29 11 2412.6CCK, LPL, STX4, IAPP, DBI, NAT2
45ibmx45 29 6011.6CCK, SCT, LPL, IAPP
46cysteine459.3SCT, PRSS1, LIPF, IAPP, BAK1, NQO1
47serine459.2SCT, PRSS1, LIPF, IAPP, NQO1, PNLIP
48glucose459.0CCK, SCT, LPL, STX4, IAPP, BAK1
49calcium45 50 11 2412.0CCK, SCT, STX4, PRSS1, IAPP, BAK1
50lipid458.9SCT, LPL, STX4, LIPF, IAPP, DBI

GO Terms for genes affiliated with Alcoholic Pancreatitis

Sources:
16Gene Ontology
See all sources

Cellular components related to Alcoholic Pancreatitis according to GeneCards/GeneDecks:

idNameGO IDScoreTop Affiliating Genes
1extracellular regionGO:0055769.1SPINK1, PNLIP, IAPP, LIPF, PRSS1, LPL

Biological processes related to Alcoholic Pancreatitis according to GeneCards/GeneDecks:

idNameGO IDScoreTop Affiliating Genes
1triglyceride metabolic processGO:0066419.9CYP2E1, DBI, LIPF, LPL
2response to drugGO:0424939.7GSTT1, CYP2E1, BAK1, LPL
3xenobiotic metabolic processGO:0068059.6NQO1, CYP2E1, NAT2, ADH1B, GSTT1
4response to ethanolGO:0454719.6BAK1, NQO1, CYP2E1
5small molecule metabolic processGO:0442819.0LPL, PRSS1, NQO1, CYP2E1, NAT2, PNLIP

Molecular functions related to Alcoholic Pancreatitis according to GeneCards/GeneDecks:

idNameGO IDScoreTop Affiliating Genes
1hormone activityGO:00517910.0IAPP, SCT, CCK
2triglyceride lipase activityGO:0048069.5PNLIP, LIPF, LPL

Products for genes affiliated with Alcoholic Pancreatitis

  • Antibodies
  • Proteins
  • Lysates
  • Antibodies

Sources for Alcoholic Pancreatitis

3CDC
13ExPASy
14FMA
22GTR
23HGMD
24HMDB
25ICD10
26ICD10 via Orphanet
27ICD9CM
29IUPHAR
30KEGG
35MeSH
36MESH via Orphanet
37MGI
40NCIt
41NDF-RT
44NINDS
45Novoseek
47OMIM
48OMIM via Orphanet
51PubMed
52QIAGEN
58SNOMED-CT via Orphanet
61UMLS
62UMLS via Orphanet