MCID: ALC005
MIFTS: 36

Alcoholic Pancreatitis malady

Categories: Endocrine diseases

Aliases & Classifications for Alcoholic Pancreatitis

Aliases & Descriptions for Alcoholic Pancreatitis:

Name: Alcoholic Pancreatitis 12 14
Pancreatitis, Alcoholic 42 69
Pancreatitis Alcoholic 52

Classifications:



External Ids:

Disease Ontology 12 DOID:4988
MeSH 42 D019512
SNOMED-CT 64 445507008
UMLS 69 C0376670

Summaries for Alcoholic Pancreatitis

MalaCards based summary : Alcoholic Pancreatitis, also known as pancreatitis, alcoholic, is related to tropical calcific pancreatitis and pancreatitis. An important gene associated with Alcoholic Pancreatitis is SPINK1 (Serine Peptidase Inhibitor, Kazal Type 1), and among its related pathways/superpathways are Cytochrome P450 - arranged by substrate type and Drug metabolism - cytochrome P450. The drugs Dexmedetomidine and Propofol have been mentioned in the context of this disorder. Affiliated tissues include pancreas, liver and testes.

Related Diseases for Alcoholic Pancreatitis

Diseases related to Alcoholic Pancreatitis via text searches within MalaCards or GeneCards Suite gene sharing:

(show all 46)
id Related Disease Score Top Affiliating Genes
1 tropical calcific pancreatitis 11.2
2 pancreatitis 10.7
3 fibrosis of extraocular muscles, congenital, 3c 10.2 CFTR SPINK1
4 cavernous sinus thrombosis 10.2 PRSS1 SPINK1
5 autosomal dominant intermediate charcot-marie-tooth 10.2 CFTR PRSS1
6 diastrophic dysplasia 10.2 PRSS1 SPINK1
7 lethal hydranencephaly-diaphragmatic hernia syndrome 10.1 ADH1B CYP2E1
8 primary congenital glaucoma 10.1 CFTR PRSS1 SPINK1
9 tricuspid valve insufficiency 10.1 CCK PRSS1
10 female stress incontinence 10.1 CCK CFTR
11 short bowel syndrome 10.0 CCK CFTR
12 chondroma 10.0 CCK PRSS1 SPINK1
13 recurrent acute pancreatitis 10.0
14 lacrimal system cancer 10.0 CCK LPL SPINK1
15 emery-dreifuss muscular dystrophy, x-linked 10.0 CYP2E1 GSTM1
16 acute gonococcal cervicitis 10.0 CCK PRSS1
17 myxofibrosarcoma 10.0 CFTR LPL PRSS1 SPINK1
18 alcohol-related birth defect 9.9 ADH1B ALDH2
19 gastrointestinal tularemia 9.9 CFTR GSTM1
20 duodenitis 9.8
21 personality disorder 9.8 ADH1B ALDH2 CCK
22 lymphoblastic lymphoma 9.8 ADH1B ALDH2 CYP2E1
23 netherton syndrome 9.8 ADH1B CCK CFTR PRSS1 SPINK1
24 uvula cancer 9.7 ALDH2 CYP2E1 GSTM1
25 hepatitis 9.7
26 cystic fibrosis 9.6
27 pancreatic cancer 9.6
28 alcohol abuse 9.6
29 liver cirrhosis 9.6
30 liver disease 9.6
31 gastroduodenitis 9.6
32 preeclampsia/eclampsia 5 9.6 ADH1B ALDH2 CCK CYP2E1
33 thyroid gland disease 9.6 ADH1B CCK CFTR LPL PRSS1 SPINK1
34 anal fistula 9.6 ADH1B ALDH2 CYP2E1 GSTM1
35 obesity 9.5
36 hepatitis b 9.5
37 thrombosis 9.5
38 parotitis 9.5
39 pericardial effusion 9.5
40 duodenal ulcer 9.5
41 thrombophilia 9.5
42 acute pancreatitis 9.5
43 adenocarcinoma 9.5
44 mediastinitis 9.5
45 peritonitis 9.5
46 cervical adenomyoma 8.7 ADH1B ALDH2 CCK CFTR CYP2E1 GSTM1

Graphical network of the top 20 diseases related to Alcoholic Pancreatitis:



Diseases related to Alcoholic Pancreatitis

Symptoms & Phenotypes for Alcoholic Pancreatitis

Drugs & Therapeutics for Alcoholic Pancreatitis

Drugs for Alcoholic Pancreatitis (from DrugBank, HMDB, Dgidb, PharmGKB, IUPHAR, NovoSeek, BitterDB):

(show top 50) (show all 53)
id Name Status Phase Clinical Trials Cas Number PubChem Id
1
Dexmedetomidine Approved, Vet_approved Phase 4 76631-46-4, 113775-47-6 68602 5311068 56032
2
Propofol Approved, Investigational, Vet_approved Phase 4 2078-54-8 4943
3
Octreotide Approved, Investigational Phase 4 83150-76-9 383414 6400441
4
Somatostatin Approved Phase 4 38916-34-6, 51110-01-1 53481605
5 Peripheral Nervous System Agents Phase 4,Phase 3,Phase 2
6 Antineoplastic Agents, Hormonal Phase 4,Phase 3,Phase 2
7 Gastrointestinal Agents Phase 4,Phase 3,Phase 2
8 Hormone Antagonists Phase 4,Phase 3,Phase 2
9 Hormones Phase 4,Phase 3,Phase 2
10 Hormones, Hormone Substitutes, and Hormone Antagonists Phase 4,Phase 3,Phase 2
11 Adrenergic Agents Phase 4
12 Adrenergic Agonists Phase 4
13 Adrenergic alpha-2 Receptor Agonists Phase 4
14 Adrenergic alpha-Agonists Phase 4
15 Analgesics Phase 4
16 Analgesics, Non-Narcotic Phase 4
17 Central Nervous System Depressants Phase 4
18 Hypnotics and Sedatives Phase 4
19 Neurotransmitter Agents Phase 4
20
Methylprednisolone Approved, Vet_approved Phase 3,Phase 2 83-43-2 6741
21
Pentoxifylline Approved, Investigational Phase 3,Early Phase 1 6493-05-6 4740
22
Prednisolone Approved, Vet_approved Phase 3,Phase 2 50-24-8 5755
23
Adenosine Approved, Investigational Phase 3 58-61-7 60961
24 Antiemetics Phase 3,Phase 2
25 Anti-Inflammatory Agents Phase 3,Phase 2
26 Antioxidants Phase 3,Early Phase 1
27 Autonomic Agents Phase 3,Phase 2
28 glucocorticoids Phase 3,Phase 2
29 Methylprednisolone acetate Phase 3,Phase 2
30 Methylprednisolone Hemisuccinate Phase 3,Phase 2
31 Neuroprotective Agents Phase 3,Phase 2
32 Phosphodiesterase Inhibitors Phase 3,Early Phase 1
33 Platelet Aggregation Inhibitors Phase 3,Early Phase 1
34 Prednisolone acetate Phase 3,Phase 2
35 Prednisolone hemisuccinate Phase 3,Phase 2
36 Prednisolone phosphate Phase 3,Phase 2
37 Protective Agents Phase 3,Phase 2,Early Phase 1
38 Radiation-Protective Agents Phase 3,Early Phase 1
39 Vasodilator Agents Phase 3,Early Phase 1
40 Micronutrients Phase 3
41 Trace Elements Phase 3
42 Vitamins Phase 3
43 Liver Extracts Phase 2
44
Ethanol Approved 64-17-5 702
45
Pancrelipase Approved 53608-75-6
46
Ergocalciferol Approved, Nutraceutical 50-14-6 5280793
47 Pharmaceutical Solutions
48 pancreatin
49 Bone Density Conservation Agents
50 Ergocalciferols

Interventional clinical trials:

(show all 17)
id Name Status NCT ID Phase
1 Dexmedetomidine Versus Placebo in Endoscopic Retrograde Cholangiopancreatography (ERCP) Sedation Completed NCT01070680 Phase 4
2 Somatostatin, Octreotide, Pentoxyfilline in the Prevention of Post-ERCP Pancreatitis and Molecular Markers Completed NCT00222092 Phase 4
3 Short-term Survival in Patients With Severe Alcoholic Hepatitis Treated With Steroid Versus Pentoxifylline Unknown status NCT01455337 Phase 3
4 Pentoxifylline Treatment in Acute Pancreatitis (AP) Enrolling by invitation NCT02487225 Phase 3
5 Comparison of Bovine Colostrum Versus Placebo in Treatment of Severe Alcoholic Hepatitis: A Randomized Double Blind Controlled Trial Not yet recruiting NCT02473341 Phase 3
6 Efficacy of Combination Therapy of Glucocorticoids and Bovine Colostrum in Treatment of Severe Alcoholic Hepatitis. Completed NCT02265328 Phase 2
7 Recurrence of Acute Alcoholic Pancreatitis Completed NCT00523874
8 Decrease of Recurrent Pancreatitis Completed NCT00534534
9 Helicobacter Pylori and Acute Alcohol Induced Pancreatitis Completed NCT00490386
10 Moderate Versus Aggressive Fluids for Acute Pancreatitis Completed NCT01761539
11 Pentoxifylline Treatment of Acute Pancreatitis Completed NCT01292005 Early Phase 1
12 Surgical Outcome and Differences on Histopathology in Patients With Alcoholic & Non Alcoholic Chronic Pancreatitis Completed NCT02048267
13 CT Pancreas Perfusion Completed NCT00588367
14 Prognostic Indicators as Provided by the EPIC ClearView Completed NCT01476995
15 The Effect of Vitamin D Substitution on the Development of Chronic Pancreatitis Recruiting NCT02965898
16 ERCP-induced and Non-ERCP Induced Acute Pancreatitis: Two Distinct Clinical and Immunological Entities? Enrolling by invitation NCT02602574
17 Albumindialysis in Acute Pancreatitis Suspended NCT00483912

Search NIH Clinical Center for Alcoholic Pancreatitis

Cochrane evidence based reviews: pancreatitis, alcoholic

Genetic Tests for Alcoholic Pancreatitis

Anatomical Context for Alcoholic Pancreatitis

MalaCards organs/tissues related to Alcoholic Pancreatitis:

39
Pancreas, Liver, Testes, Skin, Spinal Cord

Publications for Alcoholic Pancreatitis

Articles related to Alcoholic Pancreatitis:

(show top 50) (show all 252)
id Title Authors Year
1
The Long-term Prospective Follow-up of Pancreatic Function After the First Episode of Acute Alcoholic Pancreatitis: Recurrence Predisposes One to Pancreatic Dysfunction and Pancreatogenic Diabetes. ( 28060789 )
2017
2
Purtscher's-like retinopathy in acute alcoholic pancreatitis. ( 27628016 )
2016
3
Genetically Determined Chronic Pancreatitis but not Alcoholic Pancreatitis Is a Strong Risk Factor for Pancreatic Cancer. ( 27518468 )
2016
4
Purtscher-like retinopathy in acute alcoholic pancreatitis. ( 27433040 )
2016
5
Alcoholic pancreatitis: New insights into the pathogenesis and treatment. ( 26909228 )
2016
6
Elizabethkingia miricola bacteriemia in a young woman with acute alcoholic pancreatitis. ( 26337359 )
2015
7
Alcoholic Pancreatitis Masquerading as Preeclampsia. ( 26375717 )
2015
8
Pharmacological attenuation of chronic alcoholic pancreatitis induced hypersensitivity in rats. ( 25624717 )
2015
9
Hemosuccus pancreaticus caused by rupture of a splenic artery pseudoaneurysm complicating chronic alcoholic pancreatitis: an uncommon cause of gastrointestinal bleeding. ( 26712055 )
2015
10
Polymorphism of Alcohol Metabolizing Gene ADH3 Predisposes to Development of Alcoholic Pancreatitis in North Indian Population. ( 26734614 )
2015
11
Pancreatic morphological changes in long-term follow-up after initial episode of acute alcoholic pancreatitis. ( 24002755 )
2014
12
Alcoholic pancreatitis: A tale of spirits and bacteria. ( 24891979 )
2014
13
Goal-related outcome after acute alcohol-pancreatitis -- a two-year follow-up study. ( 24018221 )
2013
14
Should pancreatectomy with islet cell autotransplantation in patients with chronic alcoholic pancreatitis be abandoned? ( 23521936 )
2013
15
Necro-inflammatory response of pancreatic acinar cells in the pathogenesis of acute alcoholic pancreatitis. ( 24091659 )
2013
16
Is alcoholic pancreatitis associated with enteroviral infection? ( 23840120 )
2013
17
Sex and age differences in alcoholic pancreatitis in Japan: a multicenter nationwide survey. ( 23508016 )
2013
18
Effects of oxidative alcohol metabolism on the mitochondrial permeability transition pore and necrosis in a mouse model of alcoholic pancreatitis. ( 23103769 )
2013
19
Alcoholic pancreatitis and midgut malrotation. ( 22880504 )
2012
20
Stellate cell activation in tropical calcific pancreatitis compared to alcoholic pancreatitis, adenocarcinoma of pancreas and normal pancreas. ( 22797393 )
2012
21
Low plasma antibodies specific for phosphatidylethanol in alcohol abusers and patients with alcoholic pancreatitis. ( 21309928 )
2012
22
Serum proinflammatory cytokine levels and white blood cell differential count in patients with different degrees of severity of acute alcoholic pancreatitis. ( 22763297 )
2012
23
Extrahepatic portal venous system thrombosis in recurrent acute and chronic alcoholic pancreatitis is caused by local inflammation and not thrombophilia. ( 22825367 )
2012
24
Smoking and the course of recurrent acute and chronic alcoholic pancreatitis: a dose-dependent relationship. ( 23086245 )
2012
25
Recent advances in the epidemiology of alcoholic pancreatitis. ( 21243451 )
2011
26
Investigating the pathobiology of alcoholic pancreatitis. ( 21284675 )
2011
27
Anthropometric measurements of nutritional status in chronic pancreatitis in India: comparison of tropical and alcoholic pancreatitis. ( 21509539 )
2011
28
Alcoholic pancreatitis complicated by an intra-abdominal abscess. ( 21443884 )
2011
29
Association analyses of genetic polymorphisms of GSTM1, GSTT1, NQO1, NAT2, LPL, PRSS1, PSTI, and CFTR with chronic alcoholic pancreatitis in Japan. ( 18986377 )
2010
30
Electronic clinical challenges and images in GI. A simple case of alcoholic pancreatitis. ( 20347040 )
2010
31
Mechanisms of alcoholic pancreatitis. ( 21091991 )
2010
32
Beer and its non-alcoholic compounds: role in pancreatic exocrine secretion, alcoholic pancreatitis and pancreatic carcinoma. ( 20617020 )
2010
33
Fatty acid composition of plasma lipid classes in chronic alcoholic pancreatitis. ( 20980776 )
2010
34
Alcoholic pancreatitis: lessons from the liver. ( 20238397 )
2010
35
Effects of gadolinium chloride and glycine on hepatic and pancreatic tissue damage in alcoholic pancreatitis. ( 19924020 )
2010
36
Striving for abstinence in alcoholic pancreatitis: act of humanity, economic necessity, or flogging a dead horse after all? ( 19171144 )
2009
37
New insights into alcoholic pancreatitis and pancreatic cancer. ( 19799699 )
2009
38
Pancreas: alcoholic pancreatitis--it's the alcohol, stupid. ( 19494819 )
2009
39
Ascites with Strongyloides stercoralis in a patient with acute alcoholic pancreatitis and liver cirrhosis. ( 19795035 )
2009
40
Pancreatic damage after the first episode of acute alcoholic pancreatitis and its association with the later recurrence rate. ( 19407478 )
2009
41
Alcoholic pancreatitis: pathogenesis, incidence and treatment with special reference to the associated pain. ( 20049222 )
2009
42
A novel SPINK1 gene mutation, c.206C>T, in a Thai patient with chronic alcoholic pancreatitis. ( 18182741 )
2008
43
Morphological and functional evaluation of the pancreatic duct with secretin-stimulated magnetic resonance cholangiopancreatography in alcoholic pancreatitis patients. ( 18470615 )
2008
44
Endotoxin as a trigger of alcoholic pancreatitis. ( 18242233 )
2008
45
Individual susceptibility to alcoholic pancreatitis. ( 18336667 )
2008
46
Association analysis among polymorphisms of the various genes and chronic alcoholic pancreatitis. ( 18336668 )
2008
47
VAMP8 is the v-SNARE that mediates basolateral exocytosis in a mouse model of alcoholic pancreatitis. ( 18535671 )
2008
48
Spinal cord stimulation for chronic visceral pain secondary to chronic non-alcoholic pancreatitis. ( 18496389 )
2008
49
Alcoholic pancreatitis: new pathogenetic insights. ( 18663346 )
2008
50
Alcoholic pancreatitis: mechanisms of viral infections as cofactors in the development of acute and chronic pancreatitis and fibrosis. ( 17095612 )
2007

Variations for Alcoholic Pancreatitis

Expression for Alcoholic Pancreatitis

Search GEO for disease gene expression data for Alcoholic Pancreatitis.

Pathways for Alcoholic Pancreatitis

Pathways related to Alcoholic Pancreatitis according to GeneCards Suite gene sharing:

id Super pathways Score Top Affiliating Genes
1
Show member pathways
12.77 ADH1B ALDH2 CYP2E1 GSTM1 NQO2
2
Show member pathways
12.14 ADH1B ALDH2 CYP2E1 GSTM1
3
Show member pathways
11.85 ADH1B ALDH2 CYP2E1
4 11.12 CYP2E1 LPL
5
Show member pathways
10.95 ADH1B ALDH2
6 10.78 CYP2E1 GSTM1
7
Show member pathways
10.47 ADH1B ALDH2
8
Show member pathways
10.2 ADH1B CYP2E1
9
Show member pathways
9.98 ADH1B ALDH2 CYP2E1
10 9.73 CYP2E1 GSTM1

GO Terms for Alcoholic Pancreatitis

Cellular components related to Alcoholic Pancreatitis according to GeneCards Suite gene sharing:

id Name GO ID Score Top Affiliating Genes
1 extracellular exosome GO:0070062 9.1 ALDH2 CFTR LPL NQO2 PRSS1 SPINK1

Biological processes related to Alcoholic Pancreatitis according to GeneCards Suite gene sharing:

id Name GO ID Score Top Affiliating Genes
1 oxidation-reduction process GO:0055114 9.46 ADH1B ALDH2 CYP2E1 NQO2
2 triglyceride metabolic process GO:0006641 8.96 CYP2E1 LPL
3 ethanol oxidation GO:0006069 8.62 ADH1B ALDH2

Molecular functions related to Alcoholic Pancreatitis according to GeneCards Suite gene sharing:

id Name GO ID Score Top Affiliating Genes
1 enzyme binding GO:0019899 9.13 CFTR CYP2E1 GSTM1
2 oxidoreductase activity GO:0016491 8.92 ADH1B ALDH2 CYP2E1 NQO2

Sources for Alcoholic Pancreatitis

3 CDC
7 CNVD
9 Cosmic
10 dbSNP
11 DGIdb
16 ExPASy
18 FMA
28 GO
29 GTR
30 HGMD
31 HMDB
32 HPO
33 ICD10
34 ICD10 via Orphanet
35 ICD9CM
36 IUPHAR
37 KEGG
38 LifeMap
40 MedGen
42 MeSH
43 MESH via Orphanet
44 MGI
46 NCI
47 NCIt
48 NDF-RT
51 NINDS
52 Novoseek
54 OMIM
55 OMIM via Orphanet
59 PubMed
60 QIAGEN
65 SNOMED-CT via Orphanet
67 TGDB
68 Tocris
69 UMLS
70 UMLS via Orphanet
Content
Loading form....