MCID: ALC005
MIFTS: 47

Alcoholic Pancreatitis malady

Endocrine diseases category

Summaries for Alcoholic Pancreatitis

About this section
Sources:
32MalaCards
See all sources

Fully expand this MalaCard

Export this MalaCard
MalaCards: Alcoholic Pancreatitis, also known as pancreatitis, alcoholic, is related to pancreatitis and acute pancreatitis. An important gene associated with Alcoholic Pancreatitis is SPINK1 (serine peptidase inhibitor, Kazal type 1), and among its related pathways are acetone degradation I (to methylglyoxal) and ethanol degradation II. The compounds acetone and epft have been mentioned in the context of this disorder. Affiliated tissues include liver, pancreas and testes, and related mouse phenotypes are liver/biliary system and homeostasis/metabolism.

Aliases & Classifications for Alcoholic Pancreatitis

About this section
Sources:
8Disease Ontology, 10DISEASES, 44Novoseek, 60UMLS, 34MeSH
See all sources

Classifications:

Malacards categories (disease lists): (See all malacards categories)
Anatomical: Endocrine diseases


Aliases & Descriptions:

alcoholic pancreatitis 8 10
pancreatitis, alcoholic 60
pancreatitis alcoholic 44


External Ids:

Disease Ontology8 DOID:4988
MeSH34 D019512

Related Diseases for Alcoholic Pancreatitis

About this section
Sources:
17GeneCards, 18GeneDecks
See all sources

Diseases related to Alcoholic Pancreatitis via text searches within MalaCards or GeneCards/GeneDecks gene sharing:

(show top 50)    (show all 93)
idRelated DiseaseScoreTop Affiliating Genes
1pancreatitis31.7PRSS1, SPINK1
2acute pancreatitis31.2CCK, ADH1B, SPINK1, TMPRSS15, PNLIP, REG3A
3hepatitis30.3CYP2E1, NAT2, KRT8, GSTT1
4alcoholic liver cirrhosis30.1ADH1B, NAT2, CYP2E1
5liver cirrhosis30.1ADH1B, KRT8, CYP2E1, SCT
6cystic fibrosis30.1SCT, LPL, PRSS1, REG3A, NAT2, PNLIP
7recurrent acute pancreatitis29.9SPINK1, LPL, SCT
8pancreatic cancer29.9CCK, SCT, KRT8, SPINK1
9obesity29.9CCK, LPL, IAPP, CYP2E1, PNLIP
10adenocarcinoma29.9CCK, SCT, PRSS1, IAPP, BAK1, NQO1
11duodenitis10.3
12alcoholic hepatitis10.2
13alcohol abuse10.1
14gastroduodenitis10.1
15liver disease10.1
16hyperparathyroidism10.0SCT
17squamous cell carcinoma10.0ADH1B
18lung cancer10.0CYP2E1
19cholesterol ester storage disease10.0PNLIP
20tropical calcific pancreatitis10.0SPINK1
21esophageal cancer10.0CYP2E1, ADH1B
22hereditary pancreatitis10.0SPINK1, PRSS1
23myeloma10.0BAK1, PRSS1
24duodenogastric reflux10.0CCK
25celiac disease10.0CCK
26hypoglycemia10.0IAPP, SCT
27pancreatic steatorrhea10.0PNLIP, PRSS1
28gastritis10.0SCT, CCK
29oral cancer10.0GSTT1, CYP2E1
30exocrine pancreatic insufficiency10.0PNLIP, SCT, CCK
31leukoplakia10.0GSTT1, KRT8
32hepatoblastoma10.0NQO1, NQO2, CYP2E1
33brain cancer10.0NQO1, GSTT1
34motor neuron disease10.0GSTT1
35schizophrenia10.0CCK, SCT, NQO1, NQO2
36steatorrhea10.0CCK, SCT, PNLIP, TMPRSS15
37laryngeal benign neoplasm10.0BAK1, NAT2, GSTT1
38neuroendocrine tumor10.0CCK, SCT, KRT8
39fatty liver disease10.0LPL, DBI, CYP2E1
40acute lymphoblastic leukemia, childhood10.0GSTT1, CYP2E1, NQO1
41cholangiocarcinoma10.0SCT, NAT2, PNLIP, KRT8
42nasopharynx carcinoma10.0GSTT1, NAT2, CYP2E1
43insulin resistance10.0CYP2E1, DBI, IAPP, LPL
44transitional cell carcinoma10.0NAT2, KRT8, SPINK1, GSTT1
45morbid obesity10.0LPL, CCK
46galactosemia10.0CYP2E1, KRT8, SPINK1, ADH1B
47basal cell carcinoma10.0BAK1, KRT8, GSTT1
48cervical cancer10.0BAK1, KRT8, SPINK1, GSTT1
49fibrosarcoma10.0NQO1, KRT8, SPINK1
50hyperinsulinism10.0CCK, SCT, LPL, IAPP, PNLIP

Graphical network of the top 20 diseases related to Alcoholic Pancreatitis:



Diseases related to alcoholic pancreatitis

Clinical Features for Alcoholic Pancreatitis

About this section

Drugs & Therapeutics for Alcoholic Pancreatitis

About this section
Sources:
5CenterWatch, 41NIH Clinical Center, 6ClinicalTrials, 60UMLS, 40NDF-RT
See all sources

Approved drugs:

Search CenterWatch for Alcoholic Pancreatitis

Drug clinical trials:

Search ClinicalTrials for Alcoholic Pancreatitis

Search NIH Clinical Center for Alcoholic Pancreatitis

Search CenterWatch for Alcoholic Pancreatitis

Genetic Tests for Alcoholic Pancreatitis

About this section

Anatomical Context for Alcoholic Pancreatitis

About this section
Sources:
32MalaCards
See all sources

MalaCards organs/tissues related to Alcoholic Pancreatitis:

32
Liver, Pancreas, Testes, Skin, Spinal cord, Kidney, Breast, Monocytes

Animal Models for Alcoholic Pancreatitis or affiliated genes

About this section
Sources:
36MGI
See all sources

MGI Mouse Phenotypes related to Alcoholic Pancreatitis:

36
idDescriptionMGI Source AccessionScoreTop Affiliating Genes
1MP:00053709.4KRT8, PNLIP, CYP2E1, NQO1, DBI, LPL
2MP:00053767.4GSTT1, CCK, SCT, LPL, STX4, IAPP

Publications for Alcoholic Pancreatitis

About this section
Sources:
50PubMed
See all sources

Articles related to Alcoholic Pancreatitis:

(show top 50)    (show all 346)
idTitleAuthorsYear
1
The number of tandem repeats in the carboxyl-ester lipase (CEL) gene as a risk factor in alcoholic and idiopathic chronic pancreatitis. (23395566)
2013
2
Alcoholic liver disease and pancreatitis: global health problems being addressed by the US National Institute on Alcohol Abuse and Alcoholism. (23855288)
2013
3
Alcoholic chronic pancreatitis and alcoholic liver cirrhosis: differences in alcohol use habits and patterns in Indian subjects. (22481284)
2012
4
Alcoholic chronic pancreatitis and liver cirrhosis: coincidence and differences in lifestyle. (22898631)
2012
5
The prevalence of cationic trypsinogen (PRSS1) and serine protease inhibitor, Kazal type 1 (SPINK1) gene mutations in Polish patients with alcoholic and idiopathic chronic pancreatitis. (20676769)
2011
6
Anthropometric measurements of nutritional status in chronic pancreatitis in India: comparison of tropical and alcoholic pancreatitis. (21509539)
2011
7
Mechanisms of alcoholic pancreatitis. (21091991)
2010
8
Mechanism and regulation of folate uptake by pancreatic acinar cells: effect of chronic alcohol consumption. (20360131)
2010
9
Association analyses of genetic polymorphisms of GSTM1, GSTT1, NQO1, NAT2, LPL, PRSS1, PSTI, and CFTR with chronic alcoholic pancreatitis in Japan. (18986377)
2010
10
Impact of alcohol consumption with polymorphisms in alcohol-metabolizing enzymes on pancreatic cancer risk in Japanese. (19068087)
2009
11
Alcohol-metabolizing enzyme gene polymorphisms and alcohol chronic pancreatitis among Polish individuals. (18773092)
2008
12
Pancreatic stellate cells and chronic alcoholic pancreatitis. (17356252)
2007
13
Cystic dystrophy of the duodenal wall associated with chronic alcoholic pancreatitis. Clinical features, diagnostic procedures and therapeutic management in a retrospective multicenter series of 23 patients. (16733382)
2006
14
Pathophysiology of alcoholic pancreatitis: an overview. (17167828)
2006
15
Gene-environment factors that contribute to alcoholic pancreatitis in humans. (16958673)
2006
16
Comparison of histology and extracellular matrix between autoimmune and alcoholic chronic pancreatitis. (15782107)
2005
17
Treatment of alcoholic pancreatitis. (16508288)
2005
18
Genetic polymorphisms of alcohol-metabolizing enzymes and cytokines in patients with alcohol induced pancreatitis and alcoholic liver cirrhosis]. (15220553)
2004
19
Alcohol modulates circulating levels of interleukin-6 and monocyte chemoattractant protein-1 in chronic pancreatitis. (15074399)
2004
20
Homozygous (TG)11 allele in intron 8 of the cystic fibrosis transmembrane conductance regulator (CFTR) gene has a protective role against bicarbonate decrease in pure pancreatic juice among Japanese male alcoholics. (15645646)
2004
21
Alcohol and zymogen activation in the pancreatic acinar cell. (14576492)
2003
22
Animal models in alcoholic pancreatitis--what can we learn? (12138724)
2002
23
Alcoholic pancreatitis in rats: injury from nonoxidative metabolites of ethanol. (12065293)
2002
24
Study of polymorphisms in the CYP2E1 gene in patients with alcoholic pancreatitis. (11331106)
2001
25
Alcohol-related cirrhosis with pancreatitis. The role of oxidative stress in the progression of the disease. (11348018)
2001
26
Serum levels of cytokines in alcoholic liver cirrhosis and pancreatitis. (11059648)
2000
27
The pancreatitis-associated protein in hereditary and chronic alcoholic pancreatitis. (10505755)
1999
28
Pancreatic duct obstruction is an aggravating factor in the canine model of chronic alcoholic pancreatitis. (9797381)
1998
29
Acute alcoholic pancreatitis does not lead to complete recovery. (9088129)
1996
30
Quantitative analysis of collagen and collagen subtypes I, III, and V in human pancreatic cancer, tumor-associated chronic pancreatitis, and alcoholic chronic pancreatitis. (8532652)
1995
31
Amount of alcohol is an important determinant of the severity of acute alcoholic pancreatitis. (8284758)
1994
32
Serum apolipoprotein A-I in alcoholic patients with chronic calcifying pancreatitis. (2122444)
1990
33
A prospective study of ERCP in the investigation of the patients after acute non-alcoholic pancreatitis. (2262754)
1990
34
Pancreatic cancer, alcohol, diabetes mellitus and gall-bladder disease. (2925272)
1989
35
Acute (nonprogressive) alcoholic pancreatitis: prospective longitudinal study of 144 patients with recurrent alcoholic pancreatitis. (3575305)
1986
36
Management of pancreatic pseudocysts in chronic alcoholic pancreatitis with duct dilatation. (4019085)
1985
37
Hypophosphataemia and disturbed phosphate metabolism in alcoholic pancreatitis. (6464628)
1984
38
The role of pancreatobiliary duct anatomy in the etiology of alcoholic pancreatitis. (6501827)
1984
39
Evidence for an inherited predisposition to alcoholic pancreatitis. A controlled HLA typing study. (6589150)
1984
40
Prevalence of normal serum amylase levels in patients with acute alcoholic pancreatitis. (6193932)
1983
41
Gastric secretion, gastroduodenal histological changes, and serum gastrin in chronic alcoholic pancreatitis. (7072677)
1982
42
Sixteen years follow-up of a patient with alcoholic pancreatitis: serial findings of morphology and function on the pancreas and the liver. (7141202)
1982
43
Extrahepatic obstruction in chronic alcoholic pancreatitis. (7013536)
1981
44
Liver histopathology in chronic common bile duct stenosis due to chronic alcoholic pancreatitis. (7286890)
1981
45
Peritoneal dialysis in the treatment of acute alcoholic pancreatitis. (7376052)
1980
46
Pancreatic abscess after alcoholic pancreatitis. (7396698)
1980
47
A clinical investigation of chronic pancreatitis--comparative study between alcoholic pancreatitis and non-alcoholic pancreatitis--. (669197)
1978
48
Predictive value of biochemical indexes in acute alcoholic pancreatitis. (617496)
1977
49
Alcoholic pancreatitis. (1082071)
1975
50
Pancreatitis. The role of vagotomy, antrectomy, and Billroth II gastroenterostomy in the treatment of alcoholic pancreatitis. (5042804)
1972

Genetic Variations for Alcoholic Pancreatitis

About this section

Expression for genes affiliated with Alcoholic Pancreatitis

About this section
Sources:
1BioGPS, 15Gene Expression Omnibus DataSets
See all sources
Expression patterns in normal tissues for genes affiliated with Alcoholic Pancreatitis

Search GEO for disease gene expression data for Alcoholic Pancreatitis.

Pathways for genes affiliated with Alcoholic Pancreatitis

About this section
Sources:
37NCBI BioSystems Database, 49PharmGKB, 12EMD Millipore, 29KEGG, 53Reactome
See all sources

Compounds for genes affiliated with Alcoholic Pancreatitis

About this section
Sources:
44Novoseek, 28IUPHAR, 49PharmGKB, 11DrugBank, 24HMDB, 59Tocris Bioscience, 2BitterDB
See all sources

Compounds related to Alcoholic Pancreatitis according to GeneCards/GeneDecks:

(show top 50)    (show all 121)
idCompoundScoreTop Affiliating Genes
1acetone4410.5GSTT1
2epft4410.4SCT, CCK
3trans,trans-muconic acid4410.4GSTT1, CYP2E1, NQO1
4s-phenylmercapturic acid4410.4GSTT1, CYP2E1, NQO1
5styrene4410.3GSTT1, NAT2, CYP2E1
6trichloroethylene4410.3GSTT1, NAT2, CYP2E1
7omeprazole44 28 49 11 2414.3CCK, SCT, CYP2E1, NAT2
8clofibrate44 28 1112.3CYP2E1, NQO1, LPL
9hydroquinone44 2411.3NQO1, NQO2, CYP2E1
10isoniazid49 44 1112.3CYP2E1, NAT2, GSTT1
11chlorzoxazone44 28 1112.2NAT2, CYP2E1, NQO1
12rsai4410.2CYP2E1, NAT2, ADH1B, GSTT1
13pristimerin5910.2LPL, LIPF, PNLIP
14gsk 264220a5910.2LPL, LIPF, PNLIP
15mspi4410.2CYP2E1, NAT2, ADH1B, GSTT1
161-hydroxypyrene4410.2NQO1, CYP2E1, NAT2, GSTT1
17jzl 1845910.2LPL, LIPF, PNLIP
18benzene4410.2NQO1, CYP2E1, NAT2, GSTT1
19gsts4410.2NQO1, CYP2E1, NAT2, GSTT1
20beta-naphthoflavone44 1111.2NQO1, NQO2, CYP2E1
21benzo(a)pyrene4410.2NQO1, NQO2, NAT2, GSTT1
22paraoxon44 2411.2LPL, CYP2E1, NAT2, PNLIP
23epoxide4410.2GSTT1, NAT2, CYP2E1, NQO1
24quinone44 2411.1NQO1, NQO2, KRT8, GSTT1
25drugs for treatment of tuberculosis4910.1GSTT1, NAT2
26orlistat44 59 1112.1CCK, LPL, LIPF, PNLIP
27acetaminophen44 2 49 11 2414.1CCK, IAPP, NQO1, CYP2E1, NAT2
28hydrocarbons4410.1NQO1, NAT2, GSTT1
29taurocholate4410.0CCK, SCT, LPL, PNLIP, TMPRSS15
30olestra4410.0PNLIP, CCK
31tolbutamide44 49 28 1113.0NAT2, CYP2E1, NQO1
32glycerol44 11 2411.9CCK, LPL, CYP2E1, PNLIP, ADH1B
33caffeine44 49 28 2 11 2414.9CCK, LPL, CYP2E1, NAT2
34resveratrol44 59 11 2412.9CYP2E1, NQO2, NQO1, BAK1
35dopamine44 28 11 2412.9CCK, SCT, IAPP, NQO1, CYP2E1, ADH1B
36polysaccharide449.8CCK, LPL, PRSS1, LIPF, TMPRSS15
37norepinephrine44 11 2411.8CCK, SCT, LPL, IAPP, NQO1, PNLIP
38ethanol44 49 11 2412.8SCT, CYP2E1, PNLIP, KRT8, ADH1B, GSTT1
39creatinine449.8IAPP, NQO1, CYP2E1, KRT8, SPINK1, GSTT1
40trypsinogen449.8SPINK1, CCK, SCT, PRSS1, REG3A, PNLIP
41testosterone44 59 11 2412.7CCK, SCT, LPL, IAPP, NQO1, CYP2E1
42arginine449.7CCK, SCT, PRSS1, IAPP, NQO1, TMPRSS15
43dexamethasone44 49 28 1112.6CCK, LPL, IAPP, BAK1, NQO1, CYP2E1
44cholesterol44 28 11 2412.6CCK, LPL, STX4, IAPP, DBI, NAT2
45ibmx44 28 5911.6CCK, SCT, LPL, IAPP
46cysteine449.3SCT, PRSS1, LIPF, IAPP, BAK1, NQO1
47serine449.2SCT, PRSS1, LIPF, IAPP, NQO1, PNLIP
48glucose449.0CCK, SCT, LPL, STX4, IAPP, BAK1
49calcium44 49 11 2412.0CCK, SCT, STX4, PRSS1, IAPP, BAK1
50lipid448.9SCT, LPL, STX4, LIPF, IAPP, DBI

GO Terms for genes affiliated with Alcoholic Pancreatitis

About this section
Sources:
16Gene Ontology
See all sources

Cellular components related to Alcoholic Pancreatitis according to GeneCards/GeneDecks:

idNameGO IDScoreTop Affiliating Genes
1extracellular regionGO:0055769.1SPINK1, PNLIP, IAPP, LIPF, PRSS1, LPL

Biological processes related to Alcoholic Pancreatitis according to GeneCards/GeneDecks:

idNameGO IDScoreTop Affiliating Genes
1triglyceride metabolic processGO:0066419.9CYP2E1, DBI, LIPF, LPL
2response to drugGO:0424939.7GSTT1, CYP2E1, BAK1, LPL
3xenobiotic metabolic processGO:0068059.6NQO1, CYP2E1, NAT2, ADH1B, GSTT1
4response to ethanolGO:0454719.6BAK1, NQO1, CYP2E1
5small molecule metabolic processGO:0442819.0LPL, PRSS1, NQO1, CYP2E1, NAT2, PNLIP

Molecular functions related to Alcoholic Pancreatitis according to GeneCards/GeneDecks:

idNameGO IDScoreTop Affiliating Genes
1hormone activityGO:00517910.0IAPP, SCT, CCK
2triglyceride lipase activityGO:0048069.5PNLIP, LIPF, LPL

Products for genes affiliated with Alcoholic Pancreatitis

About this section
  • Antibodies
  • Proteins
  • Lysates
  • Antibodies

Sources for Alcoholic Pancreatitis

About this section
3CDC
13ExPASy
14FMA
22GTR
23HGMD
24HMDB
25ICD10
26ICD10 via Orphanet
27ICD9CM
28IUPHAR
29KEGG
34MeSH
35MESH via Orphanet
36MGI
39NCIt
40NDF-RT
43NINDS
44Novoseek
46OMIM
47OMIM via Orphanet
50PubMed
51QIAGEN
57SNOMED-CT via Orphanet
60UMLS
61UMLS via Orphanet