Aldosteronism malady

Wikipedia: Hyperaldosteronism, also aldosteronism, is a medical condition where too much aldosterone is produced by...⁴⁴ more...

MalaCards: Aldosteronism, also known as hyperaldosteronism, is related to hypertension and hyperaldosteronism. An important gene associated with Aldosteronism is CYP11B2 (cytochrome P450, family 11, subfamily B, polypeptide 2), and among its related pathways are Apoptosis and survival Anti-apoptotic action of membrane-bound ESR1 and Signal transduction_PTEN pathway. The drugs spironolactone and spironolactone pwdr [va product] and the compounds potassium and threonine have been mentioned in the context of this disorder. Affiliated tissues include brain, skin and liver, and related mouse phenotypes are renal/urinary system and hematopoietic system.

aldosteronism 7 hyperaldosteronism 43

Diseases related to aldosteronism by text searches and GeneDecks gene sharing:

(show top 50)    (show all 797)

id	Related Disease	Score	Top Affiliating Genes
1	hypertension	38.7	REN, GNB3, CYP11B2, NOS2, NOS3, ACE
2	hyperaldosteronism	36.7	REN, CLCNKB, KCNJ1, KCNK9, KCNJ5, SCNN1G
3	glucocorticoid-remediable aldosteronism	35.6	REN, KCNJ5, CYP11B2, CYP11B1, NR3C1, NR3C2
4	essential hypertension	35.0	REN, RENBP, RETN, SGK1, KISS1, SERPINE1
5	congestive heart failure	34.2	PIK3CG, REN, SGK1, UTS2, AQP2, CYP11B2
6	adrenal hyperplasia	34.1	REN, SFRP1, CGA, AVP, AVPR1A, AVPR2
7	adrenal adenoma	33.3	REN, CHGA, MEN1, APC, MC2R, HSD3BP4
8	hypoaldosteronism	32.7	REN, INS, IL6, CYP11B2, ACE, POMC
9	conn's syndrome	32.3	REN, KCNJ5, HSD3B1, CYP11B2, CYP11B1, NR3C2
10	familial hyperaldosteronism	32.3	REN, KCNJ5, CYP11B2, CYP11B1, AGTR1, POMC
11	pseudohypoaldosteronism	31.6	REN, SGK1, KCNJ1, SCNN1A, SCNN1B, SCNN1G
12	malignant hypertension	31.6	REN, EDN1, ACE, AGT, AGTR1, NPPB
13	adrenocortical carcinoma	31.6	VIP, UTS2, SCARB1, CHGA, MC2R, IGF1R
14	addison's disease	31.6	REN, SERPINA6, SCARB1, CHGA, S100A6, INS
15	hypokalemia	31.3	REN, VIP, CLCNKB, KCNE1, KCNJ1, KCNQ1
16	liddle syndrome	30.3	REN, SCNN1D, SCNN1A, SCNN1B, SCNN1G, IGF1
17	11-beta-hydroxylase deficiency	30.3	REN, GH1, CYP11B2, CYP11B1, CYP21A2
18	hypertrophic cardiomyopathy	30.0	REN, RETN, RAF1, CMA1, CD36, MMP2
19	pseudohypoaldosteronism type i	29.9	SGK1, SCNN1A, SCNN1B, SCNN1G, NR3C2, EPHA3
20	adenoma	29.9	PIK3CA, REN, RETN, KISS1, KISS1R, SFRP1
21	cushing's syndrome	29.7	HSD11B2, GH1, NR3C1, NR3C2, CRH, POMC
22	polycystic ovary syndrome	29.2	LHCGR, CGA, FST, IRS1, IRS2, INS
23	21-hydroxylase deficiency	29.1	HSD3B1, HSD3B2, HLA-B, TNXB, SULT2A1, CYP11B2
24	pre-eclampsia	29.0	REN, RETN, KISS1, SERPINA6, SERPINE1, NAGLU
25	otosclerosis	28.8	BMP2, BMP4, CD36, IL6, COL1A1, COL1A2
26	adrenocortical insufficiency	28.6	INS, CYP21A2, NR5A1, CRH, STAR, POMC
27	hypertensive heart disease	28.5	CD36, MMP1, MMP9, CYP11B2, NR3C2, ACE
28	adrenocortical tumor	28.5	VEGFA, LHCGR, SCARB1, CHGA, ATF1, MMP2
29	liver cirrhosis	28.5	REN, RETN, VIP, RAF1, UTS2, AVP
30	pulmonary hypertension	28.4	PIK3CG, VIP, BMP2, BMP4, BMPR1A, BMPR2
31	diabetes insipidus	28.4	REN, CLCNKB, CGA, AVP, AVPR1A, AVPR2
32	systolic heart failure	28.2	CMA1, MMP2, IL6, CYP11B2, NR3C2, EDN1
33	twin-to-twin transfusion syndrome	28.1	REN, VEGFA, B2M, ALB, EDN1, NPPA
34	twin twin transfusion syndrome	28.1	REN, VEGFA, B2M, ALB, EDN1, NPPA
35	gitelman syndrome	28.1	REN, CLCNKB, KCNJ1, MAPK1, IGF1, DYT10
36	alcoholism	27.9	MAOA, CCKBR, CCK, HTR2A, HTR3A, TRH
37	sleep apnea	27.9	RETN, NPPB, NPY, KNG1, ADRB2, ADIPOQ
38	teratocarcinoma	27.8	SERPINE1, BMP2, CGA, JUN, FST, CD36
39	proteinuria	27.8	REN, RENBP, SERPINE1, NAGLU, VEGFA, BMP6
40	bartter disease	27.8	PIK3CB, PIK3CA, PIK3R1, REN, VIP, BMP6
41	pulmonary edema	27.8	REN, VEGFA, SCNN1A, ATP1A1, INS, IL1B
42	prolactinoma	27.5	VIP, BMP2, BMP4, CHGA, CGA, INS
43	hyperprolactinemia	27.4	VIP, CGA, INS, IL6, IGF1, HTR2A
44	atrial fibrillation	27.2	PIK3CA, REN, RETN, SERPINE1, UTS2, KCNE1
45	myocardial infarction	27.1	PIK3CG, REN, RETN, SERPINE1, VIP, NAGLU
46	nephropathy	27.0	REN, RENBP, RETN, SGK1, GCH1, SERPINE1
47	obesity, association with	26.6	RETN, SERPINE1, NAMPT, UCP1, INS, IL6
48	acute myocardial infarction	26.6	PIK3CG, REN, RETN, SERPINE1, VIP, NAGLU
49	cerebrovascular disease	26.4	REN, RETN, SERPINE1, VIP, VEGFA, CETP
50	primary hyperparathyroidism	26.4	KL, SERPINE1, KCNQ1, CHGA, B2M, CD36

Approved drugs:

Drug clinical trials:

Inferred drug relations via UMLS/NDF-RT:

^43 28 spironolactone, spironolactone pwdr [va product]

MalaCards organs/tissues related to aldosteronism:

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MGI Mouse Phenotypes related to aldosteronism:

²⁵ (show all 28)

id	Description	MGI Source Accession	Score	Top Affiliating Genes
1	renal/urinary system phenotype	MP:0005367	11.7	KL, REN, RENBP, SGK1, KISS1, KISS1R
2	hematopoietic system phenotype	MP:0005397	11.4	KISS1R, SFN, SFRP1, BMP4, BMPR1A, BDKRB2
3	endocrine/exocrine gland phenotype	MP:0005379	11.2	KL, KISS1, KISS1R, SFN, SERPINE2, BMP5
4	normal phenotype	MP:0002873	11.1	PIK3R1, REN, KISS1R, VIP, VEGFA, BMP2
5	mortality/aging	MP:0010768	11.1	PIK3CB, PIK3CA, KL, REN, REST, KISS1
6	respiratory system phenotype	MP:0005388	10.9	KL, BMP5, BMPR1A, BMPR2, KCNK9, SCNN1A
7	integument phenotype	MP:0010771	10.6	PIK3CG, KL, KISS1, KISS1R, SFN, RAF1
8	behavior/neurological phenotype	MP:0005386	10.4	PIK3CA, KL, REN, KISS1R, SERPINE2, SERPINA6
9	nervous system phenotype	MP:0003631	10.3	KL, REN, REST, KISS1, KISS1R, SFRP1
10	no phenotypic analysis	MP:0003012	10.2	PIK3CD, PIK3R1, REST, SGK1, SFRP1, SERPINE2
11	immune system phenotype	MP:0005387	10.2	PIK3CD, PIK3R5, KL, REN, KISS1R, SFN
12	craniofacial phenotype	MP:0005382	9.5	NAGLU, BMP4, BMP5, BMPR1A, FST, INHBB
13	embryogenesis phenotype	MP:0005380	9.4	PIK3CB, PIK3CA, REST, SFN, SFRP1, BMP5
14	growth/size phenotype	MP:0005378	9.4	PIK3CB, PIK3CA, PIK3R1, PIK3CG, KL, REN
15	pigmentation phenotype	MP:0001186	9.2	NAGLU, BMP7, BMPR1A, IRS2, MDM2, APC
16	homeostasis/metabolism phenotype	MP:0005376	9.1	PIK3CB, PIK3CD, PIK3CA, PIK3R2, PIK3R1, PIK3CG
17	limbs/digits/tail phenotype	MP:0005371	8.7	KL, SFN, SFRP1, VEGFA, BMP2, BMP4
18	liver/biliary system phenotype	MP:0005370	8.4	RETN, SFN, SERPINA6, VEGFA, BMP4, BMP5
19	reproductive system phenotype	MP:0005389	8.4	PIK3CA, REN, KISS1, KISS1R, SFN, SERPINE2
20	hearing/vestibular/ear phenotype	MP:0005377	8.4	SFN, NAGLU, BMP2, BMP4, BMP5, BMP7
21	adipose tissue phenotype	MP:0005375	8.4	PIK3CA, PIK3R1, KL, RETN, SFRP1, SERPINE1
22	digestive/alimentary phenotype	MP:0005381	8.0	KL, KISS1, KISS1R, SFN, VEGFA, BMP2
23	muscle phenotype	MP:0005369	7.8	PIK3CA, PIK3R2, PIK3R1, PIK3CG, KL, REN
24	skeleton phenotype	MP:0005390	7.8	PIK3CD, PIK3CG, SFN, SFRP1, NAGLU, VEGFA
25	vision/eye phenotype	MP:0005391	7.1	PIK3CA, REST, SFN, NAGLU, VEGFA, BMP4
26	cardiovascular system phenotype	MP:0005385	7.0	PIK3CB, PIK3CD, PIK3CA, PIK3R2, PIK3R1, PIK3CG
27	cellular phenotype	MP:0005384	6.7	PIK3CB, PIK3CD, PIK3CA, PIK3R1, PIK3R5, PIK3CG
28	tumorigenesis	MP:0002006	6.4	PIK3CB, PIK3CA, PIK3R2, PIK3R1, SFN, SERPINE1

Articles related to aldosteronism:

(show top 50)    (show all 992)

id	Title	Authors	Year	Affiliating Genes
1	A case of primary aldosteronism in pregnancy: do LH a nd GNRH receptors have a potential role in regulating aldosterone secretion? (21330483)	Albiger N.M.... Mantero F.	2011	LHCGR, GNRHR
2	Aldosterone production in human adrenocortical cells is stimulated by high-density lipoprotein 2 (HDL2) through increased expression of aldosterone synthase (CYP11B2). (21239432)	Xing Y.... Rainey W.E.	2011	CYP11B2
3	Aldosterone to renin ratio--a reliable screening tool for primary aldosteronism? (20225167)	Tomaschitz A.... Pilz S.	2010	REN
4	A dispensable role for P450(scc) in the overproductio n of aldosterone in aldosterone-producing adenoma and idiopathic hyperaldostero nism in patients with primary aldosteronism. (20066577)	Fang Y.... Duren A.	2010	CYP11A1
5	Within-patient reproducibility of the aldosterone: re nin ratio in primary aldosteronism. (19933925)	Rossi G.P.... Mantero F.	2010	REN
6	Teratocarcinoma-derived growth factor-1 is upregulate d in aldosterone-producing adenomas and increases aldosterone secretion and inh ibits apoptosis in vitro. (20385969)	Williams T.A.... Mulatero P.	2010	CASP3, TDGF1
7	CYP11B2 gene haplotypes independently and in concurre nce with aldosterone and aldosterone to renin ratio increase the risk of hypert ension. (19786005)	Nejatizadeh A.... Pasha M.A.	2010	CYP11B2
8	Aldosterone antisecretagogue and antihypertensive act ions of adrenomedullin in patients with primary aldosteronism. (20150911)	Kita T.... Kitamura K.	2010	NPPB, ADM
9	Graz Endocrine Causes of Hypertension (GECOH) study: a diagnostic accuracy study of aldosterone to active renin ratio in screening for primary aldosteronism. (19351411)	Pilz S.... Pieber T.R.	2009	REN
10	Role of aldosterone in the progression of chronic kid ney disease and potential use of aldosterone blockade in children. (19347366)	Ku E.... Campese V.M.	2009	NR3C2
11	A lifetime of aldosterone excess: long-term consequences of altered regulation of aldosterone production for cardiovascular function. (18292466)	Connell J.M.... Davies E.	2008	NR3C2, CYP11B2
12	Prevalence of primary aldosteronism among unselected hypertensive patients: a prospective study based on the use of an aldosterone/renin ratio above 25 as a screening test. (17460380)	Fogari R.... Mugellini A.	2007	REN
13	Down-regulation of D2 dopamine receptor and increased protein kinase Cmu phosphorylation in aldosterone-producing adenoma play roles in aldosterone overproduction. (17299068)	Chang H.W.... Wu K.D.	2007	DRD2
14	Does the aldosterone:renin ratio predict the efficacy of spironolactone over bendroflumethiazide in hypertension? A clinical trial p rotocol for RENALDO (RENin-ALDOsterone) study. (17490489)	Parthasarathy H.K.... Macdonald T.M.	2007	REN
15	Evidence for a role of vasopressin in the control of aldosterone secretion in primary aldosteronism: in vitro and in vivo studies. (16449345)	Perraudin V.... Kuhn J.M.	2006	REN
16	Association of aldosterone synthase gene -344T/C polymorphism with plasma aldosterone and angiotensin II concentration in hypertensive patients (16796847)	Hu B.C.... Zhu D.L.	2006	CYP11B2
17	Optimal use and interpretation of the aldosterone renin ratio to detect aldosterone excess in hypertension. (16617310)	Doi S.A.... Al-Shoumer K.A.	2006	REN
18	Analysis of unilateral adrenal hyperplasia with primary aldosteronism from the aspect of messenger ribonucleic acid expression for steroidogenic enzymes: a comparative study with adrenal cortices adhering to aldosterone-producing adenoma. (16282357)	Shigematsu K.... Takahara O.	2006	CYP21A2
19	Plasma aldosterone to renin ratio predicts treatment response in primary aldosteronism: is volume loading needed? (16126559)	Juutilainen A.M.... Niskanen L.	2005	REN
20	Dual blockade of the renin-angiotensin-aldosterone system in diabetic nephropathy: the role of aldosterone. (15918104)	Schjoedt K.J.... Parving H.H.	2005	ACE
21	Primary aldosteronism with HIV infection: important considerations when using the aldosterone:renin ratio to screen this unique population. (16041202)	Fradley M.... Atta M.G.	2005	REN
22	Does aldosterone-to-renin ratio predict the antihypertensive effect of the aldosterone antagonist spironolactone? (16364838)	Mahmud A.... Feely J.	2005	REN
23	Aldosterone synthase gene (CYP11B2) C-344T polymorphism, plasma aldosterone, renin activity and blood pressure in a multi-ethnic population. (15361760)	Barbato A.... Cappuccio F.P.	2004	CYP11B2
24	Active renin versus plasma renin activity to define aldosterone-to-renin ratio for primary aldosteronism. (15076197)	Ferrari P.... Nussberger J.	2004	REN
25	Aldosterone and aldosterone antagonism in systemic hy pertension. (15128471)	Frishman W.H.... Stier C.T.	2004	NR3C2
26	Prevalence and role of a raised aldosterone to renin ratio in the diagnosis of primary aldosteronism: a debate on the scientific log ic of the use of the ratio in practice. (14510902)	Padfield P.L.	2003	REN
27	Aldosterone induces acute endothelial dysfunction in vivo in humans: evidence for an aldosterone-induced vasculopathy. (12241543)	Farquharson C.A.... Struthers A.D.	2002	REN
28	Ratio of serum aldosterone to plasma renin concentration in essential hypertension and primary aldosteronism. (11928071)	Trenkel S.... Hensen J.	2002	REN
29	Screening for primary aldosteronism: implications of an increased plasma aldosterone/renin ratio. (12406976)	Schwartz G.L.... Turner S.T.	2002	REN
30	Influence of antihypertensive medication on aldosterone and renin concentration in the differential diagnosis of essential hypertension and primary aldosteronism. (12354127)	Seifarth C.... Hensen J.	2002	REN
31	Variation at the aldosterone synthase (CYP11B2) locus contributes to hypertension in subjects with a raised aldosterone-to-renin ratio. (12213905)	Lim P.O.... Connell J.M.	2002	CYP11B2
32	High prevalence of primary aldosteronism using postcaptopril plasma aldosterone to renin ratio as a screening test among Italian hypertensives. (12372677)	Rossi E.... Perazzoli F.	2002	REN
33	Validity of the aldosterone-renin ratio used to scree n for primary aldosteronism. (11560297)	Montori V.M.... Turner S.T.	2001	REN
34	Screening for primary aldosteronism--normal ranges for aldosterone and renin in three South African population groups. (11544978)	Rayner B.L.... Davidson J.S.	2001	REN
35	Performance of the basal aldosterone to renin ratio and of the renin stimulation test by furosemide and upright posture in screening for aldosterone-producing adenoma in low renin hypertensives. (11549664)	Hirohara D.... Takano K.	2001	REN
36	The aldosterone/renin ratio as a screening test for primary aldosteronism. (10957926)	Rayner B.L.... Davidson J.S.	2000	REN
37	Mutations in CYP11B1 gene converting 11beta-hydroxylase into an aldosterone-producing enzyme are not present in aldosterone-producing adenomas. (10566677)	Pilon C.... Fallo F.	1999	CYP11B1
38	Aldosterone excretion rate and blood pressure in essential hypertension are related to polymorphic differences in the aldosterone synthase gene CYP11B2. (10024332)	Davies E.... Connell J.M.	1999	NR5A1
39	Hereditary defect in biosynthesis of aldosterone: aldosterone synthase deficiency 1964-1997. (9360501)	Peter M.... Sippell W.G.	1997	CYP11B2
40	Evaluation of plasma aldosterone to plasma renin activity ratio in patients with primary aldosteronism. (9249232)	Ignatowska-Switalska H.... Lewandowski J.	1997	REN
41	Conn's adenoma. Diagnostic and prognostic value of the measurement of potassium, renin, aldosterone levels and the aldosterone/renin ratio (7501604)	Massien-Simon C.... Plouin P.F.	1995	REN
42	Dopaminergic regulation of aldosterone secretion: its pathophysiologic significance in subsets of primary aldosteronism. (8529076)	Naruse M.... Demura H.	1995	REN, PRL
43	Abnormality of aldosterone and cortisol late pathways in glucocorticoid-remediable aldosteronism. (8077359)	Fallo F.... Sonino N.	1994	CYP11B2
44	Association of restriction fragment length polymorphism at the atrial natriuretic peptide gene locus with aldosterone responsiveness to angiotensin in aldosterone-producing adenoma. (7980610)	Tunny T.J.... Gordon R.D.	1994	NPPA
45	Aldosterone response to adrenocorticotrophin and furosemide in primary aldosteronism after prolonged spironolactone treatment. (7921203)	Yagi A.... Murata K.	1994	POMC
46	Renin gene polymorphism associated with aldosterone responsiveness to the renin-angiotensin system in patients with aldosterone-producing adenomas. (7902711)	Klemm S.A.... Stowasser M.	1993	REN
47	Dopaminergic regulation of aldosterone secretion: ass essment in different subtypes of primary aldosteronism and in essential hyperte nsion. (1850365)	Veglio F.... Chiandussi L.	1991	REN
48	An unexpected rise in plasma aldosterone to furosemide-upright test in primary aldosteronism due to aldosterone producing adenoma. (1663149)	Shigemasa C.... Mashiba H.	1991	POMC
49	Effects of dietary sodium restriction and posture on plasma levels of atrial natriuretic peptide, aldosterone and free aldosterone in normal human pregnancy. (2139694)	Steegers E.A.... Hein P.R.	1990	NPPA
50	A simulation study on renin and aldosterone secretions in primary aldosteronism. (1977842)	Hsieh B.S.... Lee P.W.	1990	REN

Genes related to aldosteronism according to GeneCards:

(show top 50)    (show all 282)

id	Symbol	Description	Score	GeneCards Section Context
1	CYP11B2	cytochrome P450, family 11, subfamily B, polypeptide 2	11.1	Summaries, Drugs & Compounds, Publications, Databases (show all 7 sections) Pathways & Interactions, Aliases & Descriptions, Functions
2	NR3C2	nuclear receptor subfamily 3, group C, member 2	11.1	Summaries, Publications, Aliases & Descriptions, Pathways & Interactions (show all 6 sections) Drugs & Compounds, Functions
3	AGTR1	angiotensin II receptor, type 1	11.1	Summaries, Publications, Pathways & Interactions
4	REN	renin	11.1	Summaries, Pathways & Interactions, Drugs & Compounds, Publications
5	CYP21A2	cytochrome P450, family 21, subfamily A, polypeptide 2	11.0	Publications, Summaries
6	ACE	angiotensin I converting enzyme (peptidyl-dipeptidase A) 1	11.0	Publications, Summaries
7	SCNN1D	sodium channel, non-voltage-gated 1, delta subunit	11.0	Summaries
8	HSD11B2	hydroxysteroid (11-beta) dehydrogenase 2	11.0	Pathways & Interactions, Summaries, Publications
9	NPPB	natriuretic peptide B	11.0	Summaries, Functions, Publications
10	CYP11B1	cytochrome P450, family 11, subfamily B, polypeptide 1	11.0	Pathways & Interactions, Drugs & Compounds, Publications
11	POMC	proopiomelanocortin	11.0	Publications
12	NR3C1	nuclear receptor subfamily 3, group C, member 1 (glucocorticoid receptor)	11.0	Publications
13	PRSS8	protease, serine, 8	11.0	Publications
14	NPPA	natriuretic peptide A	11.0	Publications
15	WNK4	WNK lysine deficient protein kinase 4	11.0	Publications
16	KCNJ5	potassium inwardly-rectifying channel, subfamily J, member 5	11.0	Publications
17	ADM	adrenomedullin	11.0	Functions, Publications
18	AGTR2	angiotensin II receptor, type 2	11.0	Publications
19	SLC12A3	solute carrier family 12 (sodium/chloride transporters), member 3	11.0	Publications
20	CYP11A1	cytochrome P450, family 11, subfamily A, polypeptide 1	11.0	Publications
21	CYP17A1	cytochrome P450, family 17, subfamily A, polypeptide 1	11.0	Publications, Drugs & Compounds
22	ADD1	adducin 1 (alpha)	11.0	Publications
23	INSR	insulin receptor	11.0	Pathways & Interactions, Publications
24	FXYD2	FXYD domain containing ion transport regulator 2	10.9	Pathways & Interactions, Publications
25	QRFP	pyroglutamylated RFamide peptide	10.9	Functions
26	AGT	angiotensinogen (serpin peptidase inhibitor, clade A, member 8)	10.9	Pathways & Interactions, Functions, Publications
27	FXYD4	FXYD domain containing ion transport regulator 4	10.9	Pathways & Interactions
28	ATP1B4	ATPase, Na+/K+ transporting, beta 4 polypeptide	10.9	Pathways & Interactions
29	CAMK1	calcium/calmodulin-dependent protein kinase I	10.9	Publications, Functions
30	ATP1B2	ATPase, Na+/K+ transporting, beta 2 polypeptide	10.9	Pathways & Interactions
31	GPR37	G protein-coupled receptor 37 (endothelin receptor type B-like)	10.9	Publications
32	NPTXR	neuronal pentraxin receptor	10.9	Publications
33	CYP21A1P	cytochrome P450, family 21, subfamily A, polypeptide 1 pseudogene	10.9	Publications
34	SCNN1A	sodium channel, non-voltage-gated 1 alpha subunit	10.9	Pathways & Interactions, Functions, Publications
35	SCNN1G	sodium channel, non-voltage-gated 1, gamma subunit	10.9	Pathways & Interactions, Publications, Functions
36	ATP6AP2	ATPase, H+ transporting, lysosomal accessory protein 2	10.9	Publications
37	ATP1B3	ATPase, Na+/K+ transporting, beta 3 polypeptide	10.9	Pathways & Interactions
38	RENBP	renin binding protein	10.9	Publications
39	FDX1	ferredoxin 1	10.9	Publications
40	LHCGR	luteinizing hormone/choriogonadotropin receptor	10.9	Publications
41	C1QTNF1	C1q and tumor necrosis factor related protein 1	10.9	Publications
42	SCNN1B	sodium channel, non-voltage-gated 1, beta subunit	10.9	Publications, Pathways & Interactions
43	HSD3B2	hydroxy-delta-5-steroid dehydrogenase, 3 beta- and steroid delta-isomerase 2	10.9	Publications
44	NPR1	natriuretic peptide receptor A/guanylate cyclase A (atrionatriuretic peptide receptor A)	10.9	Publications, Functions
45	UTS2R	urotensin 2 receptor	10.9	Publications
46	IRS4	insulin receptor substrate 4	10.9	Pathways & Interactions
47	SLC9A3R2	solute carrier family 9, subfamily A (NHE3, cation proton antiporter 3), member 3 regulator 2	10.9	Publications, Pathways & Interactions
48	TDGF1	teratocarcinoma-derived growth factor 1	10.9	Publications
49	ATP1A3	ATPase, Na+/K+ transporting, alpha 3 polypeptide	10.9	Pathways & Interactions
50	KCNJ1	potassium inwardly-rectifying channel, subfamily J, member 1	10.9	Pathways & Interactions, Publications

Pathways related to aldosteronism according to GeneDecks:

(show top 50)    (show all 401)

id	Pathway	Score	Top Affiliating Genes
1	Apoptosis and survival Anti-apoptotic action of membrane-bound ESR110	11.0	PIK3CD, PIK3R2
2	Signal transduction_PTEN pathway41	10.8	IRS1, IGF1R, PDPK1
3	Development_Alpha-2 adrenergic receptor activation of ERK41	10.7	PIK3R3, GNB3, CAMK2G, PDPK1, EGFR, ADRA2C
4	Apoptosis and survival_BAD phosphorylation41	10.6	PIK3CB, PIK3CD, PIK3R3, PIK3R2, PIK3R1, RAF1
5	Development_Endothelin-1/EDNRA signaling41	10.5	MAPK14, CAMK2G, SRC, EDN1, EDNRA, PRKCE
6	Transcription Receptor-mediated HIF regulation10	10.5	PIK3CD, PIK3R3, PIK3R2, PIK3R1, RAF1, IRS1
7	IL-2 Signaling Pathways37	10.4	PIK3CB, PIK3CD, PIK3R1, PIK3CG, RAF1, IRS1
8	Immune response_IFN gamma signaling pathway41	10.2	PIK3CB, PIK3CD, PIK3CA, PIK3R3, PIK3R2, PIK3R1
9	Apoptosis and survival_Role of CDK5 in neuronal death and survival41	10.2	PIK3CB, PIK3CD, PIK3CA, PIK3R2, PIK3R1, RAF1
10	Adipocytokines & Insulin Signaling37	10.2	PIK3CB, PIK3CD, PIK3R1, PIK3CG, RETN, NAMPT
11	Neurotrophin signaling pathway20	10.1	PIK3CB, PIK3CD, PIK3CA, PIK3R3, PIK3R2, PIK3R5
12	Common Cytokine Receptor Gamma-Chain Family Signaling Pathways37	10.1	PIK3CB, PIK3CD, PIK3R1, PIK3CG, RAF1, IRS1
13	Transcription CREB pathway10	10.1	PIK3CB, PIK3CD, PIK3CA, PIK3R3, PIK3R2, PIK3R1
14	Development_Prolactin receptor signaling41	10.0	PIK3CB, PIK3CD, PIK3CA, PIK3R2, PIK3R1, RAF1
15	Development PDGF signaling via MAPK cascades10	10.0	PIK3CB, PIK3CD, PIK3CA, PIK3R3, PIK3R2, PIK3R1
16	Development_IGF-1 receptor signaling41	10.0	PIK3CB, PIK3CD, PIK3CA, PIK3R3, PIK3R2, PIK3R1
17	Development_PDGF signaling via MAPK cascades41	10.0	PIK3CB, PIK3CD, PIK3CA, PIK3R3, PIK3R2, PIK3R1
18	Non-small cell lung cancer20	9.7	PIK3CB, PIK3CD, PIK3CA, PIK3R3, PIK3R2, PIK3R1
19	Cell adhesion_PLAU signaling41	9.6	PIK3CB, PIK3CD, PIK3CA, PIK3R3, PIK3R2, PIK3R1
20	eNOS Signaling36	9.4	PIK3R3, PIK3R2, PIK3R1, BMP2, BMP5, BMP6
21	Development_VEGF signaling and activation41	9.4	PIK3CB, PIK3CD, PIK3CA, PIK3R3, PIK3R2, PIK3R1
22	Focal adhesion20	9.4	PIK3CB, PIK3CD, PIK3CA, PIK3R3, PIK3R2, PIK3R1
23	Development VEGF signaling via VEGFR2 - generic cascades10	9.2	PIK3CB, PIK3CD, PIK3CA, PIK3R3, PIK3R2, PIK3R1
24	Paxillin Interactions36	9.1	PIK3R3, PIK3R2, PIK3R1, BMP2, BMP4, UTS2
25	Osteoclast differentiation20	9.1	PIK3CB, PIK3CD, PIK3CA, PIK3R3, PIK3R2, PIK3R1
26	EGF Pathway36	9.0	PIK3R3, PIK3R2, PIK3R1, RAF1, JUN, MAPK8
27	Amoebiasis20	9.0	PIK3CB, PIK3CD, PIK3CA, PIK3R3, PIK3R2, PIK3R1
28	JNK Pathway36	9.0	PIK3R1, BMP2, BMP4, BMP5, BMP6, BMP7
29	Toll-like receptor signaling pathway20	8.6	PIK3CB, PIK3CD, PIK3CA, PIK3R3, PIK3R2, PIK3R1
30	VEGF signaling pathway20	8.6	PIK3CB, PIK3CD, PIK3CA, PIK3R3, PIK3R2, PIK3R1
31	Development_VEGF signaling via VEGFR2 - generic cascades41	8.6	PIK3CB, PIK3CD, PIK3CA, PIK3R3, PIK3R2, PIK3R1
32	Development_EGFR signaling pathway41	8.6	PIK3CB, PIK3CD, PIK3CA, PIK3R2, PIK3R1, RAF1
33	CCKBR-Gastrin Stimulated Signaling36	8.6	RAF1, JUN, MAPK8, MAPK3, MAPK14, MAPK1
34	Chagas disease (American trypanosomiasis)20	8.3	PIK3CB, PIK3CD, PIK3CA, PIK3R3, PIK3R2, PIK3R1
35	14-3-3 Induced Intracellular Signaling36	8.2	PIK3R3, PIK3R2, PIK3R1, BMP2, BMP4, BMP5
36	eIF2 Pathway36	8.2	PIK3R3, PIK3R2, PIK3R1, BMP4, BMP5, BMP6
37	p53 Mediated Apoptosis36	7.9	PIK3R3, PIK3R2, PIK3R1, BMP2, BMP4, BMP5
38	Influenza A20	7.9	PIK3CB, PIK3CD, PIK3CA, PIK3R3, PIK3R2, PIK3R1
39	DHA Signaling36	7.9	PIK3R3, PIK3R2, PIK3R1, BMP2, BMP4, BMP5
40	Activation of cAMP-Dependent PKA36	7.7	BMP2, BMP4, BMP5, BMP6, BMP7, RAF1
41	Activation of PKC through GPCR36	7.6	PIK3R3, PIK3R2, PIK3R1, BMP2, BMP4, BMP5
42	Activation of PKA through GPCR36	7.5	BMP2, BMP4, BMP5, BMP6, BMP7, RAF1
43	PAK Pathway36	7.3	PIK3R3, PIK3R2, PIK3R1, BMP2, BMP4, BMP5
44	p70S6K Signaling36	7.3	PIK3R3, PIK3R2, PIK3R1, BMP2, BMP4, BMP5
45	Rho Family GTPases36	6.8	PIK3R3, PIK3R2, PIK3R1, BMP2, BMP4, BMP5
46	Tec Kinases Signaling36	6.8	PIK3R3, PIK3R2, PIK3R1, BMP2, BMP4, BMP5
47	JAK-STAT Pathway36	6.8	PIK3R3, PIK3R2, PIK3R1, BMP2, BMP4, BMP5
48	MAPK Signaling36	6.8	PIK3R3, PIK3R2, PIK3R1, BMP2, BMP4, BMP5
49	Pancreatic Adenocarcinoma36	6.6	PIK3R3, PIK3R2, PIK3R1, BMP2, BMP4, BMP5
50	TGF-Beta Pathway36	6.2	PIK3R3, PIK3R2, PIK3R1, BMP2, BMP4, BMP5

Compounds related to aldosteronism according to GeneDecks:

(show top 50)    (show all 466)

id	Compound	Score	Top Affiliating Genes
1	potassium32 9 18 9	16.7	PIK3CA, REN, SGK1, VIP, NAGLU, BMPR2
2	threonine32	11.7	BMP2, BMPR1A, BMPR2, RAF1, BDKRB2, KCNQ1
3	11beta-hydroxysteroid32	11.7	REN, RETN, SGK1, SERPINA6, MC2R, HSD11B2
4	3beta-hydroxysteroid32	11.6	LHCGR, CGA, FDX1, MC2R, HSD11B2, HSD3B1
5	digoxin32 42 34 9 18 9	16.5	REN, ATP1A2, ATP1B4, ATP1A3, ATP1A4, ATP1A1
6	chloride32	11.5	REN, SGK1, VIP, CLCNKB, KCNJ1, KCNQ1
7	17-hydroxyprogesterone32 18	12.3	REN, RETN, SERPINA6, CGA, HSD3B1, HSD3B2
8	forskolin32 42 9 9	14.3	PIK3R1, REN, RETN, VIP, BMP2, BMP4
9	acth32	11.3	REN, SERPINA6, VIP, LHCGR, SCARB1, AVP
10	fatty acid32	11.3	RETN, SFN, SERPINA6, NAMPT, SCARB1, UCP1
11	phospholipid32	11.1	PIK3CB, PIK3R1, KCNE1, KCNJ5, KCNMA1, SCARB1
12	lipid32	10.9	PIK3CB, PIK3CD, PIK3CA, PIK3R1, PIK3CG, RETN
13	inositol32	10.9	PIK3CB, PIK3CD, CHGA, INSR, CAMK2G, TRH
14	irbesartan32 9 9	12.6	REN, SERPINE1, JUN, MMP9, CCL2, ALB
15	lisinopril32 9 18 9	13.6	REN, VEGFA, BDKRB2, ALB, ABCB1, ACE
16	chloramphenicol32 9 9	12.5	SGK1, SERPINE1, RAF1, CHGA, CETP, JUN
17	perindopril32 34 9 9	13.4	REN, SERPINE1, NAGLU, VEGFA, ALB, NOS3
18	heparin32 9 18 9	13.3	PIK3CA, PIK3CG, SFRP1, SERPINE2, SERPINE1, BMP4
19	aprotinin32 9 9	12.3	VIP, NAGLU, BDKRB2, MMP2, MMP9, IL1A
20	h2o232	10.2	PIK3CB, PIK3R1, PIK3CG, SGK1, GCH1, VIP
21	estrogen32	10.1	PIK3CB, PIK3R1, RETN, KISS1, GCH1, SERPINA6
22	ro 31 822032	9.9	PIK3CG, UTS2, JUN, MAPK8, MAPK1, MAP2K1
23	atorvastatin32 34 9 18 9	13.9	RETN, VEGFA, BMP2, BMP6, SCARB1, CETP
24	metformin32 34 9 9	12.8	PIK3CA, PIK3CG, RETN, SERPINE1, NAMPT, CGA
25	cyclosporin a32 42	10.8	PIK3CA, PIK3CG, VIP, NAGLU, BMP2, BMP4
26	apocynin32	9.6	JUN, MAPK8, CAT, DYT10, CYBA, CYBB
27	5-hydroxytryptamine32	9.4	SERPINE1, VIP, BMP6, RAF1, CHGA, IL1A
28	prostacyclin32	9.3	REN, SERPINE1, VIP, VEGFA, BMP6, KCNMA1
29	ibmx32	9.1	VIP, BMP2, RAF1, CGA, JUNB, FST
30	phorbol32	9.1	RAF1, CHGA, JUN, JUNB, MMP1, MMP2
31	simvastatin32 34 42 9 18 9	13.9	SERPINE1, VEGFA, BMP2, BMP6, SCARB1, CETP
32	ns 39832 42	9.8	PIK3CG, MMP1, IL1A, IL1B, IL8, MAPK8
33	quercetin32 42 9 18 9	12.8	PIK3CB, PIK3CD, PIK3CA, PIK3R3, PIK3R2, PIK3R1
34	mannitol32 9 9	10.7	SGK1, NAGLU, B2M, CGA, IRS1, MAPK8
35	sb 20358032 42	9.3	VEGFA, BMP2, BMP4, BMP6, ATF1, JUNB
36	go 697632 42	8.9	PIK3CG, MMP2, IL8, MAPK8, MAPK3, MAPK14
37	butyrate32	7.9	BMP6, RAF1, B2M, JUN, MMP3, MMP9
38	doxorubicin32 34 9 9	10.8	PIK3CA, PIK3CG, VEGFA, BMP6, RAF1, B2M
39	wortmannin32 42	8.8	PIK3CB, PIK3CD, PIK3CA, PIK3R1, PIK3CG, SGK1
40	gefitinib32 34 9 9	10.8	PIK3CA, PIK3CG, VEGFA, MMP2, MMP9, INSR
41	diphenyleneiodonium32	7.7	VEGFA, JUN, INSR, IL1B, IL8, MAPK8
42	retinoic acid32 42 18	9.5	PIK3CA, PIK3CG, SERPINE1, BMP2, BMP4, BMP6
43	troglitazone32 42 9 9	10.4	PIK3CG, SERPINE1, BMP6, JUN, CD36, MMP1
44	gf 109203x32 42	8.4	PIK3CB, PIK3CG, VEGFA, RAF1, JUN, MMP1
45	dexamethasone32 42 34 9 9	11.3	PIK3CA, PIK3R1, REN, RETN, SGK1, SERPINA6
46	ag 147832	7.2	PIK3CA, PIK3CG, SERPINE1, RAF1, JUN, MMP2
47	paclitaxel32 34 9 9	10.0	PIK3CA, PIK3CG, VEGFA, BMP6, RAF1, CHGA
48	cisplatin32 34 9 9	9.5	PIK3CA, NAGLU, VEGFA, BMP6, RAF1, CHGA
49	curcumin32	4.9	PIK3CG, VEGFA, RAF1, JUN, MMP1, MMP2
50	genistein32 9 18 9	7.6	PIK3CA, PIK3R1, PIK3CG, SERPINE1, VEGFA, BMP2

Cellular components related to aldosteronism according to GeneDecks:

(show all 13)

id	Name	GO ID	Score	Top Affiliating Genes
1	integral to plasma membrane	GO:005887	11.8	EPHA3, OLR1, CYBB, DRD4, DRD2, TRHR
2	apical plasma membrane	GO:016324	11.3	DAB2, TDGF1, SLC9A3, SLC12A3, SLC22A5, SLC9A3R2
3	sodium:potassium-exchanging ATPase complex	GO:005890	11.1	FXYD2, ATP1B3, ATP1B1, ATP1A1, ATP1A4, ATP1A3
4	secretory granule	GO:030141	10.0	POMC, THBS1, CYBA, TRH, GIP, IL1B
5	neuronal cell body	GO:043025	9.9	CYP17A1, CYP19A1, HCN2, TGFB1, PRKCA, SOD1
6	plasma membrane	GO:005886	9.9	PDPK1, HTR4, HTR3A, HTR2A, GPRC6A, CCKBR
7	caveola	GO:005901	9.9	MAPK3, MAPK1, PTGS2, SRC, NOS3, ADRB2
8	membrane	GO:016020	9.8	NR3C1, OLR1, CYP19A1, DRD4, HLA-B, PLA2G6
9	cell surface	GO:009986	9.8	PLAUR, PDGFB, ABCB1, ACE2, TGFB1, TDGF1
10	platelet alpha granule lumen	GO:031093	9.5	KNG1, TGFB1, THBS1, EGF, PDGFB, ALB
11	extracellular region	GO:005576	8.4	AGT, ACE2, EGF, EDN2, EDN1, KLKB1
12	cytosol	GO:005829	8.3	CTGF, PPARG, NR3C1, PLA2G6, NOS2, NOS3
13	extracellular space	GO:005615	7.3	KLKB1, MMP3, MMP2, CETP, AVP, B2M

Biological processes related to aldosteronism according to GeneDecks:

(show top 50)    (show all 95)

id	Name	GO ID	Score	Top Affiliating Genes
1	steroid metabolic process	GO:008202	11.5	CYP11A1, CYP2C9, HSD11B1, HSD3B2, SULT2A1, CYP11B2
2	excretion	GO:007588	11.4	NEDD4L, AGT, AQP5, AQP2, AVPR2, SCNN1G
3	regulation of blood pressure	GO:008217	11.4	NPR3, ATP1A1, GNB3, PTGS2, CYP11B1, PPARG
4	glucocorticoid biosynthetic process	GO:006704	11.4	HSD11B2, HSD3B1, HSD3B2, HSD11B1, CYP11B1, CYP17A1
5	regulation of vasoconstriction	GO:019229	11.2	ATP1A2, AGTR1, ACE2, ACE, EDN2, EDN1
6	elevation of cytosolic calcium ion concentration	GO:007204	11.2	AVP, UTS2R, EDN1, TRHR, GIPR, CCKBR
7	G-protein coupled receptor signaling pathway	GO:007186	11.2	PIK3CB, PIK3R5, PIK3CG, KISS1, KISS1R, GNRHR
8	cell-cell signaling	GO:007267	10.9	PGR, POMC, AGT, HCN2, EDN1, NR5A1
9	positive regulation of bone mineralization	GO:030501	10.8	ACVR1, KL, BMP2, BMP4, BMP6, BMP7
10	blood circulation	GO:008015	10.8	NPY, ELN, UTS2R, BDKRB2, KCNE1, KCNQ1
11	positive regulation of urine volume	GO:035810	10.7	EDN1, NPR3, NPPB, DRD2, HAS2, KNG1
12	small molecule metabolic process	GO:044281	10.7	ADRA2C, CD36, PIK3CA, SLC5A6, PIK3CG, PIK3CB
13	positive regulation of renal sodium excretion	GO:035815	10.6	DRD2, NPR1, NPPB, AGT, EDN1, AVPR1A
14	positive regulation of endothelial cell migration	GO:010595	10.6	PRKCA, BMP4, VEGFA, BMPR2, SCARB1, ALOX12
15	phosphatidylinositol 3-kinase cascade	GO:014065	10.5	EDN1, PIK3CB, PIK3CD, PIK3R1, PIK3R5, PIK3CG
16	response to organic cyclic compound	GO:014070	10.5	JUN, SLC9A1, TRH, NPPB, PRKCA, GIP
17	insulin receptor signaling pathway	GO:008286	10.4	PIK3R3, PIK3R2, KL, NAMPT, RAF1, PIK3R1
18	activation of adenylate cyclase activity	GO:007190	10.4	RAF1, ADCYAP1, ADRB1, ADRB2, EDNRA, PRKCA
19	positive regulation of ERK1 and ERK2 cascade	GO:070374	10.3	ADRA1A, PRKCA, EDNRA, NOX4, CTGF, DRD2
20	aging	GO:007568	10.2	HTR2A, NR3C1, NOS3, EDNRA, HCN2, AGT
21	response to mechanical stimulus	GO:009612	10.2	BMP2, BMP4, JUN, JUNB, MMP9, CCL2
22	positive regulation of osteoblast differentiation	GO:045669	10.2	BMP6, BMP4, BMP2, BMPR1A, BMP7, BMPR2
23	positive regulation of endothelial cell proliferation	GO:001938	10.2	PGF, NR4A1, VEGFA, BMP2, BMP4, PRKCA
24	cell surface receptor signaling pathway	GO:007166	10.1	GIPR, CCKBR, CCL2, MAPK14, CD36, BDKRB2
25	response to drug	GO:042493	10.1	CYP17A1, ADRA1A, CYP19A1, PPARG, CREB1, NOS3
26	phosphatidylinositol-mediated signaling	GO:048015	10.0	PIK3CA, PIK3R1, IRS1, IRS2, PDPK1, CREB1
27	positive regulation of cell migration	GO:030335	10.0	INS, COL1A1, IRS1, INSR, VEGFA, BMP2
28	synaptic transmission	GO:007268	9.9	CREB1, CAMK2G, GNB3, PRKCB, NPY, CRH
29	protein phosphorylation	GO:006468	9.9	PDGFB, CREB1, AKT1, ACVR1, WNK4, TGFB1
30	positive regulation of pathway-restricted SMAD protein phosphorylation	GO:010862	9.8	TGFB1, ACVR1, BMPR1A, BMP7, BMP6, BMP4
31	positive regulation of protein phosphorylation	GO:001934	9.8	AKT1, DAB2, MAPK3, TGFB1, IL1B, CTGF
32	response to hypoxia	GO:001666	9.8	ADM, ADIPOQ, THBS1, UTS2, PDGFB, NOS3
33	positive regulation of apoptotic process	GO:043065	9.7	NOS3, REST, APC, CCK, ALOX12, DUSP1
34	fibroblast growth factor receptor signaling pathway	GO:008543	9.6	PIK3CA, PIK3R1, KL, RAF1, FGF23, MDM2
35	positive regulation of angiogenesis	GO:045766	9.5	IL1B, MMP9, NOS3, ADM, PRKCA, PRKD1
36	neutrophil chemotaxis	GO:030593	9.5	EDN1, EDN2, SPP1, CCL2, IL1B, PIK3CG
37	response to estradiol stimulus	GO:032355	9.4	GH1, DUSP1, PTGS2, CYP19A1, CTGF, NOS3
38	response to glucocorticoid stimulus	GO:051384	9.4	HSD11B2, INSR, IL6, MAP2K1, CCL2, DUSP1
39	positive regulation of nitric oxide biosynthetic process	GO:045429	9.3	IL1B, INS, AGTR2, EGFR, HSP90AA1, PTGS2
40	positive regulation of MAP kinase activity	GO:043406	9.2	PIK3CG, KRAS, GH1, PDGFB, EGF, NOX4
41	positive regulation of cell proliferation	GO:008284	9.1	SFRP1, HTR4, ALOX12, CTGF, PDGFB, KRAS
42	nerve growth factor receptor signaling pathway	GO:048011	9.1	MAPK3, MAPK14, MAPK1, MAP2K1, CASP3, AKT1
43	epidermal growth factor receptor signaling pathway	GO:007173	8.8	EGF, EGFR, TGFB1, TDGF1, PRKCE, PRKCG
44	inflammatory response	GO:006954	8.7	IL6, IL1B, CRH, SPP1, OLR1, CYBB
45	blood coagulation	GO:007596	8.2	PIK3CB, MAPK14, MAPK1, IGF1, ALB, AKT1
46	platelet activation	GO:030168	8.1	SRC, PIK3R2, PIK3R1, PIK3R5, PIK3CG, SERPINE1
47	signal transduction	GO:007165	8.1	EPO, ADM, MAP2K1, NAMPT, SFN, PIK3CD
48	positive regulation of transcription from RNA polymerase II promoter	GO:045944	8.0	PITX2, BMP6, BMP5, BMP2, VEGFA, SERPINE1
49	negative regulation of cell proliferation	GO:008285	7.9	IGF1, GNRHR, DRD2, PTGS2, NOS3, NOX4
50	negative regulation of apoptotic process	GO:043066	7.8	SERPINE1, VEGFA, BMP4, BMP5, RAF1, BDKRB2

Molecular functions related to aldosteronism according to GeneDecks:

(show all 16)

id	Name	GO ID	Score	Top Affiliating Genes
1	sodium:potassium-exchanging ATPase activity	GO:005391	11.3	FXYD2, ATP1B3, ATP1B2, ATP1B1, ATP1A1, ATP1A4
2	neuropeptide hormone activity	GO:005184	10.7	ADCYAP1, NPY, CRH, TRH, CCK, AVP
3	hormone activity	GO:005179	10.6	EPO, GH1, GIP, IGF1, CCK, INS
4	1-phosphatidylinositol-3-kinase activity	GO:016303	10.5	PIK3CG, PIK3R2, PIK3R3, PIK3CA, PIK3CD, PIK3CB
5	protein heterodimerization activity	GO:046982	10.5	EGFR, AGTR1, TGFB1, PGF, ADRA2C, ADRA1A
6	receptor binding	GO:005102	10.5	POMC, NPPA, NPPB, NPY, SLC9A3R2, PGR
7	insulin-like growth factor receptor binding	GO:005159	10.4	IGF1, INSR, INS, ARRB1, IRS1, REN
8	insulin receptor substrate binding	GO:043560	10.3	PIK3CB, PIK3CA, PIK3R1, INSR, IGF1R, PRKCD
9	drug binding	GO:008144	10.3	ADRB1, ADRB2, ACE, PPARG, CYP2C9, DRD4
10	insulin receptor binding	GO:005158	10.0	PDPK1, IGF1, IGF1R, INS, IRS4, IRS2
11	heme binding	GO:020037	10.0	CYP21A2, CYP2C9, SRC, NOS2, NOS3, NOX4
12	protein homodimerization activity	GO:042803	9.7	OXA1L, TGFB1, ACVR1, PDGFB, PITX2, NOS2
13	ATP binding	GO:005524	9.1	PRKCG, PRKCE, ACVR1, ACTA1, ABCB11, ABCB1
14	growth factor activity	GO:008083	8.3	GH1, CTGF, PDGFB, EGF, AGT, TGFB1
15	cytokine activity	GO:005125	8.3	IL1A, IL1B, IL6, SPP1, EDN1, ADIPOQ
16	protein binding	GO:005515	8.1	PRKCA, AHCYL1, AGTR2, AGTR1, HIRA, ELN