MCID: ALD010
MIFTS: 44

Aldosteronism, Glucocorticoid-Remediable malady

Genetic diseases, Rare diseases, Cardiovascular diseases, Nephrological diseases, Endocrine diseases categories

Aliases & Classifications for Aldosteronism, Glucocorticoid-Remediable

About this section
Sources:
49OMIM, 11diseasecard, 10Disease Ontology, 45NIH Rare Diseases, 22GeneTests, 47Novoseek, 51Orphanet, 24GTR, 65UMLS, 67UniProtKB/Swiss-Prot, 29ICD9CM, 28ICD10 via Orphanet, 34MedGen, 36MeSH
See all sources

Aliases & Descriptions for Aldosteronism, Glucocorticoid-Remediable:

Name: Aldosteronism, Glucocorticoid-Remediable 49 11
Glucocorticoid-Remediable Aldosteronism 10 45 22 47 51 24 65 67
Glucocorticoid Sensitive Hypertension 45 51 67
Dexamethasone Sensitive Hypertension 45 51 67
Glucocorticoid-Suppressible Hyperaldosteronism 22 67
Hyperaldosteronism, Familial Type 1 45 22
Familial Hyperaldosteronism Type I 51 67
Gra 51 67
Fh1 51 67
Acth-Dependent Hyperaldosteronism Syndrome 67
 
Aldosteronism, Sensitive to Dexamethasone 22
Aldosteronism Sensitive to Dexamethasone 67
Familial Hyperaldosteronism Type 1 45
Familial Hyperaldosteronism 1 67
Familial Aldosteronism Type I 65
Fh Type 1 67
Fh I 67
Fh-I 51
Gsh 67


Classifications:



Characteristics (Orphanet epidemiological data):

51
glucocorticoid-remediable aldosteronism:
Inheritance: Autosomal dominant; Age of onset: Adolescent,Adult,Childhood; Age of death: normal life expectancy


External Ids:

OMIM49 103900
Disease Ontology10 DOID:14080
ICD9CM29 255.11
Orphanet51 403
ICD10 via Orphanet28 E26.0
MedGen34 C1260386
MeSH36 D006929

Summaries for Aldosteronism, Glucocorticoid-Remediable

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NIH Rare Diseases:45 Glucocorticoid-remediable aldosteronism is one of three types of familial hyperaldosteronism and was first described in 1966. aldosterone is a hormone manufactured by the adrenal glands which helps the body retain water and sodium and excrete potassium. it is caused by a fusion of the cyp11b1 and cyp11b2 genes and is inherited in an autosomal dominant manner. individuals with this condition usually have hypertension (high blood pressure) before age 21. these individuals are also at an increased risk for a certain type of stroke known as a hemorrhagic stroke. first-line therapy consists of a steroid such as prednisone, dexamethasone, or hydrocortisone. this will often correct the overproduction of aldosterone, lower the blood pressure, and correct the potassium levels. last updated: 6/12/2015

MalaCards based summary: Aldosteronism, Glucocorticoid-Remediable, also known as glucocorticoid-remediable aldosteronism, is related to adrenal gland disease and adrenal gland hyperfunction, and has symptoms including autosomal dominant inheritance, abnormality of the urinary system and hypertension. An important gene associated with Aldosteronism, Glucocorticoid-Remediable is CYP11B1 (Cytochrome P450, Family 11, Subfamily B, Polypeptide 1), and among its related pathways are superpathway of steroid hormone biosynthesis and Renin secretion. Affiliated tissues include adrenal gland, and related mouse phenotypes are adipose tissue and liver/biliary system.

OMIM:49 Glucocorticoid-remediable aldosteronism is an autosomal dominant disorder characterized by hypertension, variable... (103900) more...

UniProtKB/Swiss-Prot:67 Familial hyperaldosteronism 1: A disorder characterized by hypertension, variable hyperaldosteronism, and abnormal adrenal steroid production, including 18-oxocortisol and 18-hydroxycortisol. There is significant phenotypic heterogeneity, and some individuals never develop hypertension.

Wikipedia:68 Glucocorticoid remediable aldosteronism (GRA), also describable as aldosterone synthase hyperactivity,... more...

Related Diseases for Aldosteronism, Glucocorticoid-Remediable

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Diseases related to Aldosteronism, Glucocorticoid-Remediable via text searches within MalaCards or GeneCards Suite gene sharing:

(show top 50)    (show all 134)
idRelated DiseaseScoreTop Affiliating Genes
1adrenal gland disease30.6POMC, REN
2adrenal gland hyperfunction29.3CYP11B1, CYP11B2, HSD11B2, NR3C1, POMC, REN
3hypertension, essential28.8AGT, CYP11B1, CYP11B2, HSD11B2, NR3C1, NR3C2
4familial hyperaldosteronism10.5
5hyperaldosteronism, familial, type iii10.4
6hyperaldosteronism10.4
7intracranial aneurysm10.4
8aneurysm10.4
9endotheliitis10.4
10anemia, sideroblastic, pyridoxine-refractory, autosomal recessive10.3
11roberts syndrome10.3
12apparent mineralocorticoid excess10.3
13child syndrome10.3
14pulmonary hypertension10.3
15adenoma10.3
16congenital heart disease10.3
17kid syndrome10.3
18transposition of the great arteries10.3
19cerebral aneurysms10.3
20cystic fibrosis10.3
21familial male-limited precocious puberty10.2CYP11B1, CYP11B2
22spondylosis10.2
23cervicitis10.2
24lung cancer10.2
25breast cancer10.2
26neuronitis10.2
27marden-walker syndrome10.1NR3C2, REN
28idiopathic membranous glomerulonephritis10.1AGT, REN
29spondylocostal dysostosis - anal and genitourinary malformations10.1POMC, REN
30atrophic rhinitis10.1POMC, REN
31fibrosing mediastinitis10.1AGT, REN
32aortic dissection lentiginosis10.1AGT, CYP11B2
33adrenal gland pheochromocytoma10.1CYP11B1, POMC
34neuroblastoma10.1
35hiv-110.1
36hypoxia10.1
37malignant iris melanoma10.1AGT, REN
38renal tubular dysgenesis10.1AGT, REN
39familial hypersecretion of adrenal androgens10.1POMC, REN
40open-angle glaucoma10.1AGT, REN
41posterior cerebral artery infarction10.1POMC, REN
42intestinal benign neoplasm10.1AGT, REN
43pharyngitis10.1
44abdominal aortic aneurysm10.1
45aortic aneurysm10.1
46aortic disease10.1
47elephantiasis10.1
48nonalcoholic steatohepatitis10.1
49familial abdominal aortic aneurysm10.1
50retinal ischemia10.0NR3C2, REN

Graphical network of the top 20 diseases related to Aldosteronism, Glucocorticoid-Remediable:



Diseases related to aldosteronism, glucocorticoid-remediable

Symptoms for Aldosteronism, Glucocorticoid-Remediable

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Symptoms by clinical synopsis from OMIM:

103900

Clinical features from OMIM:

103900

HPO human phenotypes related to Aldosteronism, Glucocorticoid-Remediable:

(show all 8)
id Description Frequency HPO Source Accession
1 autosomal dominant inheritance HP:0000006
2 abnormality of the urinary system HP:0000079
3 hypertension HP:0000822
4 adrenogenital syndrome HP:0000840
5 hyperaldosteronism HP:0000859
6 decreased circulating renin level HP:0003351
7 onset HP:0003674
8 adrenal hyperplasia HP:0008221

Drugs & Therapeutics for Aldosteronism, Glucocorticoid-Remediable

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Drugs for Aldosteronism, Glucocorticoid-Remediable (from DrugBank, HMDB, Dgidb, PharmGKB, IUPHAR, NovoSeek, BitterDB):

idNameStatusPhaseClinical TrialsCas NumberPubChem Id
1
SimvastatinapprovedPhase 348279902-63-954454
Synonyms:
(+)-Simvastatin
(1S,3R,7S,8S,8aR)-8-{2-[(2R,4R)-4-hydroxy-6-oxotetrahydro-2H-pyran-2-yl]ethyl}-3,7-dimethyl-1,2,3,7,8,8a-hexahydronaphthalen-1-yl 2,2-dimethylbutanoate
2,2-Dimethylbutanoic acid (1S,3R,7S,8S,8aR)-1,2,3,7,8,8a-hexahydro-3,7-dimethyl-8-[2-[(2R,4R)-tetrahydro-4-hydroxy-6-oxo-2H-pyran-2-yl]ethyl]-1-naphthalenyl ester
2,2-Dimethylbutyric acid, 8-ester with (4R,6R)-6-(2-((1S,2S,6R,8S,8aR)-1,2,6,7,8,8a-hexahydro-8-hydroxy-2,6-dimethyl-1-naphthyl)ethyl)tetrahydro-4-hydroxy-2H-pyran-2-one
2,2-Dimethylbutyric acid, 8-ester with (4R,6R)-6-(2-((1S,2S,6R,8S,8ar)-1,2,6,7,8,8a-hexahydro-8-hydroxy-2,6-dimethyl-1-naphthyl)ethyl)tetrahydro-4-hydroxy-2H-pyran-2-one
79902-63-9
AC-1530
AC1L1H1F
AKOS005111006
ARONIS24119
BCBcMAP01_000007
BIDD:GT0769
BPBio1_001001
BRD-K22134346-001-05-8
BRN 4768037
BSPBio_000909
BSPBio_002337
Bio-0672
Butanoic acid, 2,2-dimethyl-, (1S,3R,7S,8S,*aR)-1,2,3,7,8,8a-hexahydro-3,7-dimethyl-8-(2-((2R,4R)-tetrahydro-4-hydroxy-6-oxo-2H-pyran-2-yl)ethyl)-1-naphthalenyl ester
Butanoic acid, 2,2-dimethyl-, (1S,3R,7S,8S,8aR)-1,2,3,7,8,8a-hexahydro-3,7-dimethyl-8-(2-((2R,4R)-tetrahydro-4-hydroxy-6-oxo-2H-pyran-2-yl)ethyl)-1-naphthalenyl ester
Butanoic acid, 2,2-dimethyl-, (1S,3R,7S,8S,8aR)-1,2,3,7,8,8a-hexahydro-3,7-dimethyl-8-[2-[(2R,4R)-tetrahydro-4-hydroxy-6-oxo-2H-pyran-2-yl]ethyl]-1-naphthalenyl ester
C25H38O5
CCRIS 7558
CHEBI:9150
CHEMBL1064
CID54454
CPD000718785
Cholestat
Coledis
Colemin
Corolin
D00434
D019821
DRG-0320
Denan
DivK1c_006991
Eucor
HMS1570N11
HMS1922H13
HMS2089D12
HMS2093E06
HSDB 7208
InChI=1/C25H38O5/c1-6-25(4,5)24(28)30-21-12-15(2)11-17-8-7-16(3)20(23(17)21)10-9-19-13-18(26)14-22(27)29-19/h7-8,11,15-16,18-21,23,26H,6,9-10,12-14H2,1-5H3/t15-,16-,18+,19+,20-,21-,23-/m0/s1
KBio1_001935
KBio2_002197
KBio2_004765
KBio2_007333
KBio3_001557
KBioGR_001244
KBioSS_002197
KS-1113
Kolestevan
L 644128-000U
LS-46264
Labistatin
Lipex
Lipinorm
Liponorm
Lipovas
Lodales
MK 0733
MK 733
MK-0733
MK-733
MK733
MLS001304029
MLS001333077
MLS001333078
 
MLS002154038
Medipo
Modutrol
MolPort-002-507-345
MolPort-002-885-862
NCGC00017324-01
NCGC00017324-02
NCGC00017324-03
Nivelipol
Nor-Vastina
Pantok
Pepstatin
Prestwick0_000865
Prestwick1_000865
Prestwick2_000865
Prestwick3_000865
Prestwick_171
Rechol
Rendapid
S1792_Selleck
S6196_SIGMA
SAM002589969
SMR000718785
SPBio_001881
SPBio_002830
SPECTRUM1504236
STK801938
Simcor
Simovil
Simvast CR
Simvastatin
Simvastatin & Primycin
Simvastatin (JAN/USP/INN)
Simvastatin [USAN:INN:BAN]
Simvastatin [Usan:Ban:Inn]
Simvastatin lactone
Simvastatin, Compactin
Simvastatina
Simvastatina [Spanish]
Simvastatine
Simvastatine [French]
Simvastatinum
Simvastatinum [Latin]
Simvotin
Sinvacor
Sinvascor
Sivastin
SpecPlus_000895
Spectrum2_001671
Spectrum3_000669
Spectrum4_000632
Spectrum5_001428
Spectrum_001717
Statin
Synvinolin
TNP00259
UNII-AGG2FN16EV
Valemia
Vasotenal
Velostatin
Vytorin
ZINC03780893
Zocor
Zocor (TN)
Zocor, Simlup, Simcard, Simvacor, Simvoget, Zorced, Simvastatin
Zocord
[(1S,3R,7S,8S,8aR)-8-[2-[(2R,4R)-4-hydroxy-6-oxooxan-2-yl]ethyl]-3,7-dimethyl-1,2,3,7,8,8a-hexahydronaphthalen-1-yl] 2,2-dimethylbutanoate
butanoic acid, 2,2-dimethyl-,1,2,3,7,8,8a-hexahydro-3,7-dimethyl-8-[2-(tetrahydro-4-hydroxy-6-oxo-2H-pyran-2-yl)-ethyl]-1-naphthalenyl ester, [1S-[1 alpha,3 alpha,7 beta,8 beta(2S*,4S*),-8a beta
nchembio790-comp16
simvastatin
2
RosuvastatinapprovedPhase 3402287714-41-45282455, 6439133, 446157
Synonyms:
(3R,5S,6E)-7-(4-(4-fluorophenyl)-6-(1-methylethyl)-2-(ethyl(methylsulfonyl)amino)-5-pyrimidinyl)-3,5-dihydroxy-6-heptenoic acid
(3R,5S,6E)-7-{4-(4-fluorophenyl)-2-[methyl(methylsulfonyl)amino]-6-(propan-2-yl)pyrimidin-5-yl}-3,5-dihydroxyhept-6-enoic acid
(3R,5S,6E)-7-{4-(4-fluorophenyl)-6-isopropyl-2-[methyl(methylsulfonyl)amino]pyrimidin-5-yl}-3,5-dihydroxyhept-6-enoic acid
(3R,5S,6e)-7-(4-(4-Fluorophenyl)-6-(1-methylethyl)-2-(ethyl(methylsulfonyl)amino)-5-pyrimidinyl)-3,5-dihydroxy-6-heptenoic acid
(3R,5S,6e)-7-{4-(4-fluorophenyl)-6-isopropyl-2-[methyl(methylsulfonyl)amino]pyrimidin-5-yl}-3,5-dihydroxyhept-6-enoic acid
(E,3R,5R)-7-[4-(4-fluorophenyl)-2-[methyl(methylsulfonyl)amino]-6-propan-2-ylpyrimidin-5-yl]-3,5-dihydroxyhept-6-enoic acid
(E,3R,5S)-7-[4-(4-fluorophenyl)-2-[methyl(methylsulfonyl)amino]-6-propan-2-ylpyrimidin-5-yl]-3,5-dihydroxyhept-6-enoic acid
(S-((R*,S*-(E)))- 7-(4-(4-fluorophenyl)-6-(1-methylethyl)-2-(methyl(methylsulfonyl) amino)-5-pyrimidinyl)-3,5-dihydroxy-6-heptenoic acid, calcium salt (2:1)
(S-(R*,S*-(E)))-7-(4-(4-Fluorophenyl)-6-(1-methylethyl)-2-(methyl(methylsulfonyl)amino)-5-pyrimidinyl)-3,5-dihydroxy-6-heptenoic acid, calcium salt (2:1)
147098-20-2
147098-20-2 (Calcium)
287714-41-4
6-Heptenoic acid, 7-(4-(4-fluorophenyl)-6-(1-methylethyl)-2-(ethyl(methylsulfonyl)amino)-5-pyrimidinyl)-3,5-dihydroxy-, (3R,5S,6E)
6-Heptenoic acid, 7-(4-(4-fluorophenyl)-6-(1-methylethyl)-2-(methyl(methylsulfonyl)amino)-5-pyrimidinyl)-3,5-dihydroxy-, calcium salt (2:1), (3R,5S,6E)
AC1L9J7O
AC1NR03S
AC1O5R1T
AKOS000280777
AKOS005145896
AZD-4522
Astende
BSPBio_003429
Bio-0143
CHEBI:38545
CHEMBL1200361
CHEMBL1496
CID446157
CID5282455
CID6439133
Cirantan
Cresadex
Creston
Creston (TN)
Crestor
Crestor (TN)
D01915
D08492
DB01098
HMS1922N09
HMS2093M08
HSDB 7317
 
I06-044
I06-1902
LS-181805
LS-187345
MolPort-000-883-884
MolPort-003-987-534
NCGC00178070-01
Provisacor
Pyrimidine Compound, 26
Razel
Rosedex
Rosimol
Rosumed
Rosustatin
Rosuvas
Rosuvast
Rosuvastatin
Rosuvastatin (INN)
Rosuvastatin Calcium
Rosuvastatin [INN]
Rosuvastatin calcium
Rosuvastatin calcium (JAN/USAN)
Rosuvastatin calcium [USAN]
Rosuvastatin hemicalcium
Rosvel
Rovartal
S 4522
S-4522
SPECTRUM1505213
Simestat
Sinlip
Spectrum5_001695
TL8006179
UNII-413KH5ZJ73
Visacor
Vivacor
ZD 4522
ZD 4522, calcium salt
ZD-4522
ZD4522
bis[(E)-7-[4-(4-fluorophenyl)-6-isopropyl-2-[methyl(methylsulfonyl)amino] pyrimidin-5-yl](3R,5S)-3,5-dihydroxyhelpt-6-enoic acid] calcium salt
calcium (E,3R,5S)-7-[4-(4-fluorophenyl)-2-[methyl(methylsulfonyl)amino]-6-propan-2-ylpyrimidin-5-yl]-3,5-dihydroxyhept-6-enoate
rosuvastatin calcium
3
AtorvastatinapprovedPhase 3690134523-00-560823
Synonyms:
(3R,5R)-7-[2-(4-fluorophenyl)-3-phenyl-4-(phenylcarbamoyl)-5-propan-2-ylpyrrol-1-yl]-3,5-dihydroxyheptanoic acid
(3R,5R)-7-[3-(anilinocarbonyl)-5-(4-fluorophenyl)-2-isopropyl-4-phenyl-1H-pyrrol-1-yl]-3,5-dihydroxyheptanoic acid
(R-(R*,R*))-2-(4-Fluorophenyl)-beta,delta-dihydroxy-5-(1-methylethyl)-3-phenyl-4-((phenylamino)carbonyl)-1H-pyrrole-1-heptanoic acid
(betaR,deltaR)-2-(p-Fluorophenyl)-beta,delta-dihydroxy-5-isopropyl-3-phenyl-4-(phenylcarbamoyl)pyrrole-1-heptanoic acid
134523-00-5
134523-03-8
7-[2-(4-FLUORO-PHENYL)-5-ISOPROPYL-3-PHENYL-4-PHENYLCARBAMOYL-PYRROL-1-YL]- 3,5-DIHYDROXY-HEPTANOIC ACID
AC-15611
AC1L1TZT
AC1Q1OZQ
AKOS000281127
Atogal
Atorlip
Atorpic
Atorvastatin
Atorvastatin (INN)
Atorvastatin Calcium
Atorvastatin [INN:BAN]
Atorvastatin acid
Atorvastatin calcium
BIDD:GT0336
C06834
C33H35FN2O5
CCRIS 7159
CHEBI:39548
CHEMBL1487
CI 981
CID60823
Cardyl
D07474
DB01076
Faboxim
 
HSDB 7039
Hipolixan
LS-136975
Lipitor
Lipitor (TN)
Lipitor(TM)
Lipotropic
Lipovastatinklonal
Liprimar
Lowden
MolPort-000-883-773
NCGC00159458-02
Normalip
Sincol
Sortis
Sortis (TN)
Sotis
Torvacard
Torvast
Totalip
Tozalip
Tulip
UNII-A0JWA85V8F
Vastina
Xanator
Xarator
Xavator
Zurinel
atorvastatin
atorvastatina
atorvastatine
atorvastatinium
atrovastin
nchembio.301-comp8

Interventional clinical trials:

idNameStatusNCT IDPhase
1Efficacy and Safety of Alirocumab (SAR236553/REGN727) Versus Placebo on Top of Lipid-Modifying Therapy in Patients With Heterozygous Familial Hypercholesterolemia Not Adequately Controlled With Their Lipid-Modifying TherapyCompletedNCT01623115Phase 3
2Diagnosis/Pathophysiology of Glucocorticoid Remediable Aldosteronism HypertensionCompletedNCT00005394
3Study of Prevalence and Clinical Phenotype in Patients With Glucocorticoid-Remediable AldosteronismCompletedNCT00004354

Search NIH Clinical Center for Aldosteronism, Glucocorticoid-Remediable

Genetic Tests for Aldosteronism, Glucocorticoid-Remediable

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Genetic tests related to Aldosteronism, Glucocorticoid-Remediable:

id Genetic test Affiliating Genes
1 Glucocorticoid-Remediable Aldosteronism22 24 CYP11B2

Anatomical Context for Aldosteronism, Glucocorticoid-Remediable

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MalaCards organs/tissues related to Aldosteronism, Glucocorticoid-Remediable:

33
Adrenal gland

Animal Models for Aldosteronism, Glucocorticoid-Remediable or affiliated genes

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MGI Mouse Phenotypes related to Aldosteronism, Glucocorticoid-Remediable:

38
idDescriptionMGI Source AccessionScoreTop Affiliating Genes
1MP:00053758.7AGT, CYP11B1, NR3C1, POMC
2MP:00053708.6AGT, CYP11B1, NR3C1, POMC
3MP:00053697.6AGT, CYP11B2, HSD11B2, NR3C1, NR3C2, REN
4MP:00053787.2AGT, CYP11B1, CYP11B2, NR3C1, NR3C2, POMC
5MP:00036317.1AGT, CYP11B1, NR3C1, NR3C2, POMC, REN
6MP:00107686.9AGT, CYP11B2, HSD11B2, NR3C1, NR3C2, POMC
7MP:00053676.7AGT, CYP11B1, CYP11B2, HSD11B2, NR3C1, NR3C2
8MP:00053866.6AGT, CYP11B2, HSD11B2, NR3C1, NR3C2, POMC
9MP:00053856.6AGT, CYP11B1, CYP11B2, HSD11B2, NR3C1, NR3C2
10MP:00053766.4AGT, CYP11B1, CYP11B2, HSD11B2, NR3C1, NR3C2

Publications for Aldosteronism, Glucocorticoid-Remediable

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Variations for Aldosteronism, Glucocorticoid-Remediable

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Clinvar genetic disease variations for Aldosteronism, Glucocorticoid-Remediable:

5
id Gene Variation Type Significance SNP ID Assembly Location
1CYP11B1CYP11B1, CYP11B1/CYP11B2 ANTI-LEPORE-LIKE CHIMERAundetermined variantPathogenic

Expression for genes affiliated with Aldosteronism, Glucocorticoid-Remediable

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Search GEO for disease gene expression data for Aldosteronism, Glucocorticoid-Remediable.

Pathways for genes affiliated with Aldosteronism, Glucocorticoid-Remediable

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Pathways related to Aldosteronism, Glucocorticoid-Remediable according to GeneCards Suite gene sharing:

idSuper pathways (with members indented)ScoreTop Affiliating Genes
1
Show member pathways
9.8CYP11B1, CYP11B2
29.5AGT, REN
39.4HSD11B2, NR3C2
4
Show member pathways
9.2CYP11B1, CYP11B2, POMC
5
Show member pathways
9.1CYP11B1, CYP11B2, HSD11B2
6
Show member pathways
8.7AGT, CYP11B2, NR3C2, REN
7
Show member pathways
8.7AGT, CYP11B1, POMC, REN
8
Show member pathways
8.6CYP11B1, CYP11B2, HSD11B2, POMC

GO Terms for genes affiliated with Aldosteronism, Glucocorticoid-Remediable

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Biological processes related to Aldosteronism, Glucocorticoid-Remediable according to GeneCards Suite gene sharing:

(show all 21)
idNameGO IDScoreTop Affiliating Genes
1C21-steroid hormone biosynthetic processGO:000670010.1CYP11B1, CYP11B2
2aldosterone biosynthetic processGO:003234210.1CYP11B1, CYP11B2
3cellular response to hormone stimulusGO:003287010.1CYP11B1, CYP11B2
4cortisol biosynthetic processGO:003465110.1CYP11B1, CYP11B2
5cellular response to potassium ionGO:003586510.1CYP11B1, CYP11B2
6secondary metabolite biosynthetic processGO:004455010.1CYP11B1, CYP11B2
7renin-angiotensin regulation of aldosterone productionGO:000201810.1AGT, REN
8cellular response to peptide hormone stimulusGO:007137510.1CYP11B1, CYP11B2
9regulation of blood volume by renal aldosteroneGO:000201710.1CYP11B2, HSD11B2
10drinking behaviorGO:004275610.1AGT, REN
11cellular sodium ion homeostasisGO:000688310.0AGT, NR3C2
12angiotensin maturationGO:00020039.9AGT, REN
13excretionGO:00075889.9AGT, NR3C2
14glucocorticoid biosynthetic processGO:00067049.9CYP11B1, HSD11B2
15cholesterol metabolic processGO:00082039.8CYP11B1, CYP11B2
16sterol metabolic processGO:00161259.7CYP11B1, CYP11B2
17steroid hormone mediated signaling pathwayGO:00434019.7NR3C1, NR3C2
18glucocorticoid metabolic processGO:00082119.6HSD11B2, NR3C1
19regulation of blood volume by renin-angiotensinGO:00020169.5AGT, REN
20regulation of blood pressureGO:00082178.9AGT, CYP11B1, POMC, REN
21steroid metabolic processGO:00082028.8CYP11B1, CYP11B2, HSD11B2

Molecular functions related to Aldosteronism, Glucocorticoid-Remediable according to GeneCards Suite gene sharing:

idNameGO IDScoreTop Affiliating Genes
1steroid 11-beta-monooxygenase activityGO:00045079.8CYP11B1, CYP11B2
2oxidoreductase activity, acting on paired donors, with incorporation or reduction of molecular oxygen, NAD(P)H as one donor, and incorporation of one atom of oxygenGO:00167099.8CYP11B1, CYP11B2
3corticosterone 18-monooxygenase activityGO:00477839.7CYP11B1, CYP11B2
4steroid hormone receptor activityGO:00037079.3NR3C1, NR3C2
5steroid bindingGO:00054968.3HSD11B2, NR3C1, NR3C2

Sources for Aldosteronism, Glucocorticoid-Remediable

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2CDC
14ExPASy
15FDA
16FMA
24GTR
25HGMD
26HMDB
27ICD10
28ICD10 via Orphanet
29ICD9CM
30IUPHAR
31KEGG
34MedGen
36MeSH
37MESH via Orphanet
38MGI
41NCI
42NCIt
43NDF-RT
46NINDS
47Novoseek
49OMIM
50OMIM via Orphanet
54PubMed
55QIAGEN
60SNOMED-CT via Orphanet
64Tumor Gene Family of Databases
65UMLS
66UMLS via Orphanet