MCID: ALK003
MIFTS: 30

Aleukemic Leukemia Cutis malady

Cancer diseases category

Aliases & Classifications for Aleukemic Leukemia Cutis

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Aliases & Descriptions for Aleukemic Leukemia Cutis:

Name: Aleukemic Leukemia Cutis 10 65


Classifications:



External Ids:

Disease Ontology10 DOID:6003
NCIt42 C4983

Summaries for Aleukemic Leukemia Cutis

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MalaCards based summary: Aleukemic Leukemia Cutis is related to myelodysplastic syndrome and leukemia. An important gene associated with Aleukemic Leukemia Cutis is NPM1 (Nucleophosmin (Nucleolar Phosphoprotein B23, Numatrin)), and among its related pathways are LDL Oxidation in Atherogenesis and Tyrosine Kinases / Adaptors. Affiliated tissues include monocytes, myeloid and b cells, and related mouse phenotypes are tumorigenesis and cardiovascular system.

Related Diseases for Aleukemic Leukemia Cutis

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Diseases related to Aleukemic Leukemia Cutis via text searches within MalaCards or GeneCards Suite gene sharing:

(show top 50)    (show all 80)
idRelated DiseaseScoreTop Affiliating Genes
1myelodysplastic syndrome29.7ANPEP, CD33, CD34, FLT3, NPM1, PDGFRB
2leukemia11.0
3lymphoblastic leukemia10.6
4acute monocytic leukemia10.5
5subleukemic leukemia10.5
6monocytic leukemia10.5
7myeloid leukemia10.5
8cutaneous mastocytosis10.3
9mastocytosis10.3
10acute myeloid leukemia with abnormal bone marrow eosinophils inv(16)(p13q22) or t(16;16)(p13;q22)10.3FLT3, NPM1
11acute myeloblastic leukemia without maturation10.3FLT3, NPM1
12distal hereditary motor neuropathy, type ii10.3FLT3, NPM1
13mononeuropathy10.3MPO, PDGFRB
14acute erythroid leukemia10.3FLT3, MPO
15mononeuritis of lower limb10.3MPO, PDGFRB
16acute myeloid leukemia and myelodysplastic syndromes related to topoisomerase type 2 inhibitor10.3FLT3, RUNX1
17mediastinal malignant lymphoma10.3CD33, NCAM1
18acute vascular insufficiency of intestine10.3MPO, PDGFRB
19descending colon cancer10.3HAVCR1, LYZ
20schwachman diamond type metaphyseal dysplasia10.3MYH11, NCAM1
21blepharo naso facial syndrome van maldergem type10.2NCAM1, NPM1
22haverhill fever10.2LYZ, NCAM1
23acute lymphoblastic leukemia congenital sporadic aniridia10.2ANPEP, MPO
24wheat allergic reaction10.2LYZ, PDGFRB
25acute pulmonary heart disease10.2LYZ, MPO
26tetrasomy 9p10.2ANPEP, RUNX1
27osteogenesis imperfecta - retinopathy - seizures - intellectual disability10.2FLT3, PDGFRB
28theileriasis10.2CD68, NCAM1
29parasitic protozoa infectious disease10.2CD68, NCAM1
30chronic myocardial ischemia10.2FLT3, PDGFRB, RUNX1
31signet ring basal cell carcinoma10.2CD68, LYZ
32leukemia, acute myelomonocytic, somatic, somatic10.2FLT3, PDGFRB, RUNX1
33long bone adamantinoma10.1CD68, LYZ
34cortical deafness10.1LYZ, MPO, SPN
35rubella10.1FUT4, NCAM1
36posterior corneal pigmentation10.1LYZ, MPO
37acute myeloid leukemia with inv3(p21;q26.2) or t(3;3)(p21;q26.2)10.1FLT3, MPO, MYH11, RUNX1
38corticosterone methyloxidase deficiency10.1FLT3, RUNX1
39polyclonal hypergammaglobulinemia10.1CD68, NCAM1
40upper respiratory tract disease10.1CD68, LYZ, MPO
41cavernous sinus meningioma10.1CD34, NCAM1
42lung acinar adenocarcinoma10.1CD34, PDGFRB
43osteomalacia10.1CD68, HAVCR1
44bone osteosarcoma10.1FLT3, MPO, PDGFRB, RUNX1
45adult pulmonary langerhans cell histiocytosis10.1ANPEP, FLT3, RUNX1
46compensatory emphysema10.1CD68, NCAM1, SPN
47meibomian cyst10.0CD68, FUT4
48progressive muscular atrophy10.0ANPEP, CD68, MPO
49alcoholic gastritis10.0FLT3, LYZ, MPO, NCAM1, NPM1
50macular holes10.0ANPEP, CD7, SPN

Graphical network of the top 20 diseases related to Aleukemic Leukemia Cutis:



Diseases related to aleukemic leukemia cutis

Symptoms for Aleukemic Leukemia Cutis

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Drugs & Therapeutics for Aleukemic Leukemia Cutis

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Interventional clinical trials:

Search ClinicalTrials, NIH Clinical Center for Aleukemic Leukemia Cutis

Genetic Tests for Aleukemic Leukemia Cutis

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Anatomical Context for Aleukemic Leukemia Cutis

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MalaCards organs/tissues related to Aleukemic Leukemia Cutis:

33
Monocytes, Myeloid, B cells, Bone, T cells

Animal Models for Aleukemic Leukemia Cutis or affiliated genes

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MGI Mouse Phenotypes related to Aleukemic Leukemia Cutis:

38
idDescriptionMGI Source AccessionScoreTop Affiliating Genes
1MP:00020067.9CD34, FLT3, NPM1, RARA, RUNX1, SPN
2MP:00053857.8ANPEP, FUT4, MPO, MYH11, NPM1, PDGFRB
3MP:00053974.9ANPEP, CD33, CD34, CD68, CD7, FLT3
4MP:00053874.6ANPEP, CD33, CD34, CD68, CD7, FLT3

Publications for Aleukemic Leukemia Cutis

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Articles related to Aleukemic Leukemia Cutis:

(show all 25)
idTitleAuthorsYear
1
Pediatric Aleukemic Leukemia Cutis: Report of 3 Cases and Review of the Literature. (25148106)
2014
2
Aleukemic leukemia cutis: an unusual rash in a child. (25035690)
2014
3
Recurrent aleukemic leukemia cutis in a patient with pre-B-cell acute lymphoblastic leukemia. (23733764)
2013
4
Acute myeloid leukemia 7A years after aleukemic leukemia cutis. (24261792)
2013
5
Acute promyelocytic leukemia following aleukemic leukemia cutis harboring NPM/RARA fusion gene. (22573339)
2012
6
Aleukemic leukemia cutis manifesting with disseminated nodular eruptions and a plaque preceding acute monocytic leukemia: a case report. (22187541)
2011
7
Aleukemic leukemia cutis in a child preceding T-cell acute lymphoblastic leukemia. (21895759)
2011
8
Siblings presenting with progressive congenital aleukemic leukemia cutis. (21425444)
2011
9
Aleukemic leukemia cutis with extensive bone involvement. (20708479)
2010
10
Spontaneous regression of aleukemic leukemia cutis harboring a NPM/RARA fusion gene in an infant with cutaneous mastocytosis. (19052694)
2009
11
Aleukemic leukemia cutis preceding acute monocytic leukemia: a case report. (18782972)
2008
12
Aleukemic leukemia cutis. (17456918)
2007
13
Aleukemic leukemia cutis in a patient with Philadelphia chromosome-positive biphenotypic leukemia. (15540904)
2004
14
Guess what. B-cell acute lymphoblastic leukemia with aleukemic leukemia cutis. (11275816)
2001
15
Aleukemic leukemia cutis presenting as benign-appearing exanthema. (11411915)
2001
16
Monocytic aleukemic leukemia cutis. (10565632)
1999
17
Aleukemic leukemia cutis in an adolescent boy. (10084909)
1999
18
Aleukemic leukemia cutis in a patient with acute lymphoblastic leukemia. (9555803)
1998
19
Aleukemic leukemia cutis preceding overt acute myeloid leukemia in myelodysplastic syndrome. (8980276)
1997
20
Lymphocytic aleukemic leukemia cutis. (8912603)
1996
21
Aleukemic leukemia cutis. (2406302)
1990
22
Aleukemic leukemia cutis. (3729513)
1986
23
Aleukemic leukemia cutis. An unusual presentation of acute myelomonocytic leukemia. (2943614)
1986
24
Aleukemic leukemia cutis: juvenile chronic granulocytic leukemia presenting with figurate cutaneous lesions. (6579062)
1983
25
Aleukemic leukemia cutis. (1062968)
1976

Variations for Aleukemic Leukemia Cutis

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Expression for genes affiliated with Aleukemic Leukemia Cutis

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Search GEO for disease gene expression data for Aleukemic Leukemia Cutis.

Pathways for genes affiliated with Aleukemic Leukemia Cutis

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Pathways related to Aleukemic Leukemia Cutis according to GeneCards Suite gene sharing:

idSuper pathways (with members indented)ScoreTop Affiliating Genes
19.7CD68, MPO
29.7FLT3, NPM1, PDGFRB
39.2FLT3, MPO, RARA, RUNX1
49.0CD34, NCAM1, SPN
58.9CD34, MPO, NCAM1, RUNX1
68.5ANPEP, CD34, LYZ, MPO
78.1ANPEP, CD33, CD34, CD7, FLT3

GO Terms for genes affiliated with Aleukemic Leukemia Cutis

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Cellular components related to Aleukemic Leukemia Cutis according to GeneCards Suite gene sharing:

idNameGO IDScoreTop Affiliating Genes
1external side of plasma membraneGO:00098978.4ANPEP, CD33, CD34, FLT3, NCAM1, SPN
2extracellular exosomeGO:00700627.5ANPEP, CD33, CD7, LYZ, MPO, MYH11
3cell surfaceGO:00099867.1CD34, FLT3, FUT4, NCAM1, PDGFRB, RARA
4membraneGO:00160206.6CD34, CD68, CD7, FLT3, FUT4, NCAM1

Biological processes related to Aleukemic Leukemia Cutis according to GeneCards Suite gene sharing:

(show all 8)
idNameGO IDScoreTop Affiliating Genes
1myeloid progenitor cell differentiationGO:000231810.4FLT3, RUNX1
2negative regulation of granulocyte differentiationGO:003085310.0RARA, RUNX1
3hematopoietic stem cell proliferationGO:00714259.7CD34, RUNX1
4viral entry into host cellGO:00467189.7ANPEP, HAVCR1, NCAM1
5transmembrane receptor protein tyrosine kinase signaling pathwayGO:00071699.4CD7, FLT3, PDGFRB
6tissue homeostasisGO:00018949.3CD34, PDGFRB
7hemopoiesisGO:00300979.1CD34, FLT3, RUNX1
8regulation of immune responseGO:00507769.0CD33, CD34, SPN

Molecular functions related to Aleukemic Leukemia Cutis according to GeneCards Suite gene sharing:

idNameGO IDScoreTop Affiliating Genes
1regulatory region DNA bindingGO:000097510.2RARA, RUNX1
2phosphatidylinositol 3-kinase bindingGO:00435489.8FLT3, PDGFRB
3virus receptor activityGO:00016189.5ANPEP, HAVCR1, NCAM1

Sources for Aleukemic Leukemia Cutis

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2CDC
14ExPASy
15FDA
16FMA
24GTR
25HGMD
26HMDB
27ICD10
28ICD10 via Orphanet
29ICD9CM
30IUPHAR
31KEGG
34MedGen
36MeSH
37MESH via Orphanet
38MGI
41NCI
42NCIt
43NDF-RT
46NINDS
47Novoseek
49OMIM
50OMIM via Orphanet
54PubMed
55QIAGEN
60SNOMED-CT via Orphanet
64Tumor Gene Family of Databases
65UMLS
66UMLS via Orphanet