MCID: ALK003
MIFTS: 33

Aleukemic Leukemia Cutis

Categories: Cancer diseases, Immune diseases

Aliases & Classifications for Aleukemic Leukemia Cutis

MalaCards integrated aliases for Aleukemic Leukemia Cutis:

Name: Aleukemic Leukemia Cutis 12 14 69

Classifications:



External Ids:

Disease Ontology 12 DOID:6003
NCIt 46 C4983
UMLS 69 C0887846

Summaries for Aleukemic Leukemia Cutis

MalaCards based summary : Aleukemic Leukemia Cutis is related to leukemia and acute myeloid leukemia with abnormal bone marrow eosinophils inv(16)(p13q22) or t(16;16)(p13;q22). An important gene associated with Aleukemic Leukemia Cutis is NPM1 (Nucleophosmin 1), and among its related pathways/superpathways are NF-kappaB Signaling and Transcriptional misregulation in cancer. Affiliated tissues include monocytes, myeloid and b cells, and related phenotypes are hematopoietic system and immune system

Related Diseases for Aleukemic Leukemia Cutis

Diseases related to Aleukemic Leukemia Cutis via text searches within MalaCards or GeneCards Suite gene sharing:

(show top 50) (show all 73)
# Related Disease Score Top Affiliating Genes
1 leukemia 30.5 FLT3 NPM1 RARA RUNX1
2 acute myeloid leukemia with abnormal bone marrow eosinophils inv(16)(p13q22) or t(16;16)(p13;q22) 30.1 FLT3 MPO MYH11 RUNX1
3 myeloid leukemia 29.3 CD33 FLT3 MPO MYH11 NPM1 RARA
4 myelodysplastic syndrome 28.8 ANPEP CD33 CD34 FLT3 NPM1 RUNX1
5 acute promyelocytic leukemia 26.8 ANPEP CD33 CD34 ELANE FLT3 FUT4
6 leukemia, acute myeloid 26.5 ANPEP CD33 CD34 CD7 FLT3 FUT4
7 subleukemic leukemia 11.8
8 mast-cell sarcoma 10.5 ANPEP MPO
9 acute myeloblastic leukemia without maturation 10.5 FLT3 NPM1
10 tetrasomy 21 10.5 ANPEP RUNX1
11 acute myeloblastic leukemia with maturation 10.5 FLT3 NPM1
12 acute myeloid leukemia with minimal differentiation 10.4 FLT3 MPO
13 cytogenetically normal acute myeloid leukemia 10.4 FLT3 NPM1
14 pasteurellosis 10.4 ELANE MPO
15 dermis tumor 10.4 HAVCR1 LYZ
16 acute myeloid leukemia with t(8;21)(q22;q22) translocation 10.4 FLT3 RUNX1
17 mediastinal cancer 10.3 ANPEP CD33 NCAM1
18 lymphoblastic leukemia 10.3
19 multiple cranial nerve palsy 10.3 MPO NCAM1 RUNX1
20 rapidly progressive glomerulonephritis 10.3 ELANE MPO
21 parasitic ichthyosporea infectious disease 10.3 CD68 NCAM1
22 rhinosporidiosis 10.3 CD68 NCAM1
23 erysipelas 10.3 ELANE LYZ
24 central nervous system sarcoma 10.2 CD68 LYZ
25 malignant giant cell tumor of soft parts 10.2 CD68 LYZ
26 acute proliferative glomerulonephritis 10.2 LYZ MPO
27 pericoronitis 10.2 CD68 NCAM1
28 liver sarcoma 10.2 CD68 LYZ
29 bronchopneumonia 10.2 ELANE MPO
30 lymphatic system cancer 10.2 LYZ NPM1 SPN
31 carbuncle 10.1 LYZ MPO SPN
32 leukemia, acute monocytic 10.1
33 monocytic leukemia 10.1
34 hematologic cancer 10.1 FLT3 NPM1 RUNX1
35 granulomatous myositis 10.1 CD68 LYZ NCAM1
36 lung meningioma 10.1 CD34 NCAM1
37 ulcerative stomatitis 10.1 CD68 LYZ MPO
38 chronic monocytic leukemia 10.1 CD34 MPO
39 leukemia, acute lymphoblastic 3 10.0 ANPEP FLT3 MPO RUNX1
40 bone marrow cancer 10.0 ANPEP FLT3 MPO RUNX1
41 conventional angiosarcoma 10.0 CD34 NCAM1
42 granulomatous gastritis 10.0 CD68 FUT4
43 hodgkin's lymphoma, lymphocytic depletion 10.0 CD68 FUT4
44 rhinoscleroma 10.0 CD68 NCAM1 SPN
45 cutaneous mastocytosis 10.0
46 vulvitis 9.9 ELANE MPO
47 myeloid sarcoma 9.9 ANPEP FLT3 MPO NCAM1 NPM1
48 interstitial emphysema 9.9 CD34 ELANE
49 angiomyoma 9.9 CD34 NCAM1
50 glomeruloid hemangioma 9.9 CD34 CD68

Graphical network of the top 20 diseases related to Aleukemic Leukemia Cutis:



Diseases related to Aleukemic Leukemia Cutis

Symptoms & Phenotypes for Aleukemic Leukemia Cutis

MGI Mouse Phenotypes related to Aleukemic Leukemia Cutis:

43
# Description MGI Source Accession Score Top Affiliating Genes
1 hematopoietic system MP:0005397 9.97 MPO NPM1 RARA RUNX1 ANPEP CD34
2 immune system MP:0005387 9.77 MPO NPM1 RARA RUNX1 ANPEP CD34
3 neoplasm MP:0002006 9.23 NPM1 RARA RUNX1 CD34 SPN ELANE

Drugs & Therapeutics for Aleukemic Leukemia Cutis

Search Clinical Trials , NIH Clinical Center for Aleukemic Leukemia Cutis

Genetic Tests for Aleukemic Leukemia Cutis

Anatomical Context for Aleukemic Leukemia Cutis

MalaCards organs/tissues related to Aleukemic Leukemia Cutis:

38
Monocytes, Myeloid, B Cells, Bone, T Cells

Publications for Aleukemic Leukemia Cutis

Articles related to Aleukemic Leukemia Cutis:

(show all 26)
# Title Authors Year
1
Aleukemic Leukemia Cutis Presenting as a Sole Sign of Relapsed Paediatric Acute Lymphoblastic Leukemia. ( 27408353 )
2016
2
Aleukemic leukemia cutis: an unusual rash in a child. ( 25035690 )
2014
3
Pediatric Aleukemic Leukemia Cutis: Report of 3 Cases and Review of the Literature. ( 25148106 )
2014
4
Acute myeloid leukemia 7A years after aleukemic leukemia cutis. ( 24261792 )
2013
5
Recurrent aleukemic leukemia cutis in a patient with pre-B-cell acute lymphoblastic leukemia. ( 23733764 )
2013
6
Acute promyelocytic leukemia following aleukemic leukemia cutis harboring NPM/RARA fusion gene. ( 22573339 )
2012
7
Siblings presenting with progressive congenital aleukemic leukemia cutis. ( 21425444 )
2011
8
Aleukemic leukemia cutis manifesting with disseminated nodular eruptions and a plaque preceding acute monocytic leukemia: a case report. ( 22187541 )
2011
9
Aleukemic leukemia cutis in a child preceding T-cell acute lymphoblastic leukemia. ( 21895759 )
2011
10
Aleukemic leukemia cutis with extensive bone involvement. ( 20708479 )
2010
11
Spontaneous regression of aleukemic leukemia cutis harboring a NPM/RARA fusion gene in an infant with cutaneous mastocytosis. ( 19052694 )
2009
12
Aleukemic leukemia cutis preceding acute monocytic leukemia: a case report. ( 18782972 )
2008
13
Aleukemic leukemia cutis. ( 17456918 )
2007
14
Aleukemic leukemia cutis in a patient with Philadelphia chromosome-positive biphenotypic leukemia. ( 15540904 )
2004
15
Guess what. B-cell acute lymphoblastic leukemia with aleukemic leukemia cutis. ( 11275816 )
2001
16
Aleukemic leukemia cutis presenting as benign-appearing exanthema. ( 11411915 )
2001
17
Aleukemic leukemia cutis in an adolescent boy. ( 10084909 )
1999
18
Monocytic aleukemic leukemia cutis. ( 10565632 )
1999
19
Aleukemic leukemia cutis in a patient with acute lymphoblastic leukemia. ( 9555803 )
1998
20
Aleukemic leukemia cutis preceding overt acute myeloid leukemia in myelodysplastic syndrome. ( 8980276 )
1997
21
Lymphocytic aleukemic leukemia cutis. ( 8912603 )
1996
22
Aleukemic leukemia cutis. ( 2406302 )
1990
23
Aleukemic leukemia cutis. An unusual presentation of acute myelomonocytic leukemia. ( 2943614 )
1986
24
Aleukemic leukemia cutis. ( 3729513 )
1986
25
Aleukemic leukemia cutis: juvenile chronic granulocytic leukemia presenting with figurate cutaneous lesions. ( 6579062 )
1983
26
Aleukemic leukemia cutis. ( 1062968 )
1976

Variations for Aleukemic Leukemia Cutis

Expression for Aleukemic Leukemia Cutis

Search GEO for disease gene expression data for Aleukemic Leukemia Cutis.

Pathways for Aleukemic Leukemia Cutis

GO Terms for Aleukemic Leukemia Cutis

Cellular components related to Aleukemic Leukemia Cutis according to GeneCards Suite gene sharing:

# Name GO ID Score Top Affiliating Genes
1 extracellular exosome GO:0070062 9.91 ANPEP CD33 CD7 ELANE LYZ MPO
2 azurophil granule lumen GO:0035578 9.33 ELANE LYZ MPO
3 external side of plasma membrane GO:0009897 9.26 ANPEP CD33 CD34 NCAM1
4 cell surface GO:0009986 9.1 CD34 ELANE FUT4 NCAM1 RARA SPN

Biological processes related to Aleukemic Leukemia Cutis according to GeneCards Suite gene sharing:

# Name GO ID Score Top Affiliating Genes
1 viral entry into host cell GO:0046718 9.5 ANPEP HAVCR1 NCAM1
2 defense response to bacterium GO:0042742 9.46 ELANE LYZ MPO SPN
3 hemopoiesis GO:0030097 9.43 CD34 FLT3 RUNX1
4 negative regulation of growth of symbiont in host GO:0044130 9.4 ELANE MPO
5 hematopoietic stem cell proliferation GO:0071425 9.37 CD34 RUNX1
6 neutrophil degranulation GO:0043312 9.1 ANPEP CD33 CD68 ELANE LYZ MPO
7 response to yeast GO:0001878 8.96 ELANE MPO

Molecular functions related to Aleukemic Leukemia Cutis according to GeneCards Suite gene sharing:

# Name GO ID Score Top Affiliating Genes
1 virus receptor activity GO:0001618 8.8 ANPEP HAVCR1 NCAM1

Sources for Aleukemic Leukemia Cutis

3 CDC
7 CNVD
9 Cosmic
10 dbSNP
11 DGIdb
16 ExPASy
18 FMA
27 GO
28 GTR
29 HGMD
30 HMDB
31 HPO
32 ICD10
33 ICD10 via Orphanet
34 ICD9CM
35 IUPHAR
36 KEGG
37 LifeMap
39 MedGen
41 MeSH
42 MESH via Orphanet
43 MGI
45 NCI
46 NCIt
47 NDF-RT
50 NINDS
51 Novoseek
53 OMIM
54 OMIM via Orphanet
58 PubMed
60 QIAGEN
65 SNOMED-CT via HPO
66 SNOMED-CT via Orphanet
67 TGDB
68 Tocris
69 UMLS
70 UMLS via Orphanet
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