Aliases & Classifications for Alexia

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Aliases & Descriptions for Alexia:

Name: Alexia 10 12 65
Dyslexia, Acquired 65
Acquired Dyslexia 10
 
Aphemesthaesia 10
Dyslexia 36


Classifications:



External Ids:

Disease Ontology10 DOID:13417
ICD9CM29 315.01
MeSH36 D004410

Summaries for Alexia

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Disease Ontology:10 An agnosia that is a loss of the ability to recognize text.

MalaCards based summary: Alexia, also known as dyslexia, acquired, is related to visual cortex disease and amusia. An important gene associated with Alexia is PSEN1 (Presenilin 1), and among its related pathways are Spinal Cord Injury and Alzheimers Disease Pathway. Affiliated tissues include brain, eye and temporal lobe, and related mouse phenotypes are muscle and hematopoietic system.

Related Diseases for Alexia

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Graphical network of the top 20 diseases related to Alexia:



Diseases related to alexia

Symptoms for Alexia

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Drugs & Therapeutics for Alexia

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Drugs for Alexia (from DrugBank, HMDB, Dgidb, PharmGKB, IUPHAR, NovoSeek, BitterDB):

(show all 9)
idNameStatusPhaseClinical TrialsCas NumberPubChem Id
1
Rivastigmineapproved, investigationalPhase 478123441-03-277991
Synonyms:
(S)-3-(1-(Dimethylamino)ethyl)phenyl ethylmethylcarbamate
123441-03-2
3-((1S)-1-(Dimethylamino)ethyl)phenyl N-ethyl-N-methylcarbamate
3-((1S)-1-(Dimethylamino)ethyl)phenyl ethylmethylcarbamate
3-[(1S)-1-(dimethylamino)ethyl]phenyl ethyl(methyl)carbamate
AB1004572
AC1L2U92
BIDD:GT0316
C11766
CHEMBL636
CID77991
Carbamic acid, N-ethyl-N-methyl-, 3-[(1S)-1-(dimethylamino)ethyl]phenyl ester
Carbamic acid, ethylmethyl-, 3-((1S)-1-(dimethylamino)ethyl)phenyl ester
D03822
DB00989
ENA 713 free base
Ena 713 Free Base
 
Ethylmethylcarbamic acid 3-((1S)-1-(dimethylamino)ethyl)phenyl ester
Exelon
Exelon Patch
HMS2089H18
I06-2037
LS-172571
MolPort-003-666-662
NCGC00167531-01
Rivastigmine
Rivastigmine (JAN/USAN/INN)
Rivastigmine Hydrogen Tartrate
Rivastigmine [USAN:INN]
Rivastigmine hydrogen tartrate
SDZ 212-713
UNII-PKI06M3IW0
[3-[(1S)-1-(dimethylamino)ethyl]phenyl] N-ethyl-N-methylcarbamate
m-((S)-1-(Dimethylamino)ethyl)phenyl ethylmethylcarbamate
rivastigmine
2
imatinibapprovedPhase 4567152459-95-5644241, 5291
Synonyms:
112GI019
152459-95-5
1iep
1xbb
4-(4-METHYL-PIPERAZIN-1-YLMETHYL)-N-[4-METHYL-3-(4-PYRIDIN-3-YL-PYRIMIDIN-2-YLAMINO)-PHENYL]-BENZAMIDE
4-(4-METHYL-piperazin-1-ylmethyl)-N-[4-methyl-3-(4-pyridin-3-yl-pyrimidin-2-ylamino)-phenyl]-benzamide
4-[(4-Methyl-1-piperazinyl)methyl]-N-[4-methyl-3-[[4-(3-pyridinyl)-2-pyrimidinyl]amino]-phenyl]benzamide
4-[(4-methyl-1-piperazinyl)methyl]-N-[4-methyl-3-[[4-(3-pyridinyl)-2-pyrimidinyl]amino]phenyl]-benzamide methanesulfonate
4-[(4-methylpiperazin-1-yl)methyl]-N-(4-methyl-3-{[4-(pyridin-3-yl)pyrimidin-2-yl]amino}phenyl)benzamide
4-[(4-methylpiperazin-1-yl)methyl]-N-[4-methyl-3-[(4-pyridin-3-ylpyrimidin-2-yl)amino]phenyl]benzamide
4-[(4-methylpiperazin-1-yl)methyl]-N-{4-methyl-3-[(4-pyridin-3-ylpyrimidin-2-yl)amino]phenyl}benzamide
AC-524
AC1L1K0Z
AKOS000280662
BIDD:GT0047
BRD-K92723993-066-02-9
Benzamide, 4-[(4-methyl-1-piperazinyl)methyl]-N-[4-methyl-3-[[4-(3-pyridinyl)-2-pyrimidinyl]amino]phenyl]- (9CI)
CCRIS 9076
CGP 57148B
CGP57148
CGP57148B
CHEBI:45783
CHEMBL941
CID5291
Cgp 57148
D08066
DB00619
DB03261
EN002706
FT-0083542
Glamox
Glamox (TN)
 
Gleevec
Glivec
HMS2089D03
I01-1232
Imatinib
Imatinib (INN)
Imatinib Mesylate
Imatinib Methansulfonate
Imatinib [INN:BAN]
Imatinib free base
Imatinibum
Kinome_3724
LS-182208
LS-187106
MolPort-000-883-342
N-(3-(4-(pyridin-3-yl)pyrimidin-2-ylamino)-4-methylphenyl)-4-((4-methylpiperazin-1-yl)methyl)benzamide
NCGC00159456-02
NCGC00159456-03
NCGC00159456-04
NSC743414
STI
STI 571
STI-571
STI571
STK617705
UNII-BKJ8M8G5HI
alpha-(4-Methyl-1-piperazinyl)-3'-((4-(3-pyridyl)-2-pyrimidinyl)amino)-P-toluidide
alpha-(4-Methyl-1-piperazinyl)-3'-((4-(3-pyridyl)-2-pyrimidinyl)amino)-p-tolu-p-toluidide
imatinib
nchembio.117-comp23
nchembio.162-comp5
nchembio.282-comp6
nchembio.83-comp14
sti-571
3
PancrelipaseapprovedPhase 383953608-75-6
Synonyms:
1,4-alpha-D- glucan glucanohydrolase
Creon
PA
Pancreatic alpha-amylase precursor
Pancreaze
 
Pancrelipase
Pertzye
Polocaine-mpf
Ultresa
Viokace
Zenpep
4
ZincapprovedPhase 314047440-66-623994, 32051
Synonyms:
30Zn
Cinc
Zinc
Zinc ion
 
Zincum
Zink
Zn
Zn(ii)
Zn2+
5pancreatinPhase 3839
6Insulin, Long-ActingPhase 3403
7Insulin, Globin ZincPhase 34069
8insulinPhase 34069
9Calcium, DietaryPhase 23529

Interventional clinical trials:

(show all 14)
idNameStatusNCT IDPhase
1Effects of Rivastigmine Patch on Activities of Daily Living and Cognition in Patients With Severe Dementia of the Alzheimer's Type (ACTION) (Study Protocol CENA713DUS44, NCT00948766) and a 24 Week Open-label Extension to Study CENA713DUS44CompletedNCT00948766Phase 4
2Chemotherapy and Imatinib in Young Adults With Acute Lymphoblastic Leukemia Ph (BCR-ABL) POSITIVERecruitingNCT01491763Phase 4
3Study of the Safety and Effectiveness of SAMSCA® (Tolvaptan) in Children and Adolescents With Euvolemic or Hypervolemic HyponatremiaRecruitingNCT02012959Phase 3
4Cystic Fibrosis - Insulin Deficiency, Early ActionRecruitingNCT01100892Phase 3
5Multimodal Treatment of Phonological Alexia: Behavioral & fMRI OutcomesCompletedNCT00827268Phase 1, Phase 2
6Treatments of the Post-traumatic Necrosed Immature Teeth (REV)RecruitingNCT02064517Phase 2
7Brentuximab Vedotin in Refractory/Relapsed Hodgkin Lymphoma Treated by ICENot yet recruitingNCT02686346Phase 1, Phase 2
8Therapy for Reading Problems in Adults After Brain InjuryCompletedNCT00064805
9Brain Mechanisms Underlying Reading Improvement in Central AlexiaRecruitingNCT02062619
10Initiating and Maintaining Physical Activity in Depressed IndividualsRecruitingNCT02691845
11Transcutaneous Electrical Nerve Stimulation (TENS) for Lower Urinary Tract Disorders in Parkinson's SyndromeRecruitingNCT02190851
12Effects of Music Education for Children With Reading DifficultiesActive, not recruitingNCT01388881
13App-delivered Therapy for Arabic Readers With Hemianopic AlexiaNot yet recruitingNCT02482350
14Preoperative Treatment With Noninvasive Intra-auricular Vagus Nerve Stimulation Pending Bariatric SurgeryNot yet recruitingNCT02648191

Search NIH Clinical Center for Alexia


Cochrane evidence based reviews: Dyslexia

Genetic Tests for Alexia

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Anatomical Context for Alexia

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MalaCards organs/tissues related to Alexia:

33
Brain, Eye, Temporal lobe, Parietal lobe, Cortex, Occipital lobe, Testes

Animal Models for Alexia or affiliated genes

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MGI Mouse Phenotypes related to Alexia:

38
idDescriptionMGI Source AccessionScoreTop Affiliating Genes
1MP:00053698.4APOE, PPP3CA, PSEN1, TARDBP
2MP:00053977.6APOE, MBP, PPP3CA, PSEN1, TARDBP
3MP:00036317.5APOE, MBP, PPP3CA, PSEN1, TARDBP
4MP:00053877.3APOE, MBP, PPP3CA, PSEN1, TARDBP

Publications for Alexia

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Articles related to Alexia:

(show top 50)    (show all 303)
idTitleAuthorsYear
1
Alexia Without Agraphia in a Right-Handed Individual Following Right Occipital Stroke. (26397830)
2015
2
Vanishing splenial lesion presenting as alexia with dysgraphia. (25683766)
2015
3
Pure alexia after damage to the right fusiform gyrus in a right-handed male. (25440018)
2014
4
Progressive Wallerian Degeneration of the Corpus Callosal Splenium in a Patient with Alexia Without Agraphia: Advanced MR Findings. (25489886)
2014
5
On compensatory strategies and computational models: the case of pure alexia. (24863010)
2014
6
Temporal recruitment of cortical network involved in reading epilepsy with paroxysmal alexia: a combined EEG/MEG study. (23287492)
2013
7
Left- and right-hemisphere forms of phonological alexia. (23521052)
2012
8
The evolution of alexia in two cases of posterior cortical atrophy. (21876262)
2011
9
Damage to the upper portion of area 19 and the deep white matter in the left inferior parietal lobe, including the superior longitudinal fasciculus, results in alexia with agraphia. (20798545)
2010
10
Alexia and agraphia with lesions of the angular and supramarginal gyri: evidence for the disruption of sequential processing. (19896678)
2010
11
Neurophysiological correlates of post-hypnotic alexia: a controlled study with Stroop test. (20187340)
2010
12
Multiple Oral Re-reading treatment for alexia: The parts may be greater than the whole. (20574915)
2010
13
Hanja (Ideogram) alexia and agraphia in patients with semantic dementia. (19967597)
2010
14
Do dual-route models accurately predict reading and spelling performance in individuals with acquired alexia and agraphia? (17482218)
2007
15
Top-down and bottom-up effects in pure alexia: evidence from eye movements. (17433379)
2007
16
Training phonological reading in deep alexia: does it improve reading words with low imageability? (17468994)
2007
17
Magnetic resonance tractography in a patient with alexia without agraphia. (16340212)
2005
18
Aphasia, alexia, and oral reading. (14872397)
2004
19
Alexia without agraphia in a postpartum eclamptic patient with factor V Leiden deficiency. (15037465)
2004
20
Braille alexia during visual hallucination in a blind man with selective calcarine atrophy. (12667171)
2003
21
Kinesthetic alexia due to left parietal lobe lesions. (12186998)
2002
22
Pure alexia in a Japanese-English bilingual: dissociation between the two languages. (11954857)
2002
23
Acquired alexia in multilingual aphasia and computer-assisted treatment in both languages: issues of generalisation and transfer. (11316940)
2001
24
Alexia without agraphia: a century later. (11351780)
2001
25
Posterior alexia after right occipitotemporal infarction. (11336035)
2001
26
Alexia for Braille following bilateral occipital stroke in an early blind woman. (10674462)
2000
27
Can treatment for pure alexia improve letter-by-letter reading speed without sacrificing accuracy? (10210630)
1999
28
Could pure alexia be due to a disconnection syndrome? (9521304)
1998
29
Optic aphasia with pure alexia: a mild form of visual associative agnosia? A case study. (9669108)
1998
30
Evolution of a form of pure alexia without agraphia in a child sustaining occipital lobe infarction at 2 1/2 years. (9652784)
1998
31
Kanji-predominant alexia in advanced Alzheimer's disease. (9576638)
1998
32
Alexia without either agraphia or hemianopia in temporal lobe lesion due to herpes simplex encephalitis. (7550926)
1995
33
Alexia in dementia of the Alzheimer's type. (8116346)
1993
34
Pure alexia and right hemiachromatopsia in posterior dementia. (1619420)
1992
35
Posterior cortical dementia with alexia: neurobehavioural, MRI, and PET findings. (1865209)
1991
36
Alexia without agraphia: a new case studied by CT-scan. (2747903)
1989
37
Evidence for preserved reading in 'pure alexia'. (2706436)
1989
38
Alexia with agraphia due to the left posterior inferior temporal lobe lesion--neuropsychological analysis and its pathogenetic mechanisms. (3258777)
1988
39
Alexia without agraphia and associated disorders: importance of recognition in the rehabilitation setting. (3566519)
1987
40
Alexia without agraphia: clinical-computed tomographic correlations. (3614625)
1987
41
Palinoptic phenomena as an error mechanism in resolving alexia without agraphia. A case report. (4006994)
1985
42
Visual agnosia without alexia. (6539870)
1984
43
Jules Dejerine and the third alexia. (6367721)
1984
44
Vision-specific anomia and total involvement of splenium in alexia without agraphia. (7073541)
1982
45
Pure alexia in a Kannada-English bilingual. (7285592)
1981
46
Wernicke's and global aphasia without alexia. (435133)
1979
47
Alexia without agraphia: lateral and medial infarction of left occipital lobe. (571985)
1979
48
Phonological processing in reading: data from alexia. (533851)
1979
49
Does alexia without agraphia always include hemianopsia? (855643)
1977
50
The syndrome of alexia and amnesic aphasia; subarachnoidal haemorrhage with symptom of partial occlusion of the spinal subarachnoidal space. (18866783)
1948

Variations for Alexia

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Expression for genes affiliated with Alexia

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Search GEO for disease gene expression data for Alexia.

Pathways for genes affiliated with Alexia

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Pathways related to Alexia according to GeneCards Suite gene sharing:

idSuper pathways (with members indented)ScoreTop Affiliating Genes
19.5MBP, PPP3CA
29.2APOE, PSEN1
3
Show member pathways
8.8APOE, PPP3CA, PSEN1
48.1APOE, MBP, PSEN1, TARDBP

GO Terms for genes affiliated with Alexia

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Cellular components related to Alexia according to GeneCards Suite gene sharing:

idNameGO IDScoreTop Affiliating Genes
1Z discGO:00300189.6PPP3CA, PSEN1
2neuronal cell bodyGO:00430258.4APOE, MBP, PSEN1

Biological processes related to Alexia according to GeneCards Suite gene sharing:

idNameGO IDScoreTop Affiliating Genes
1positive regulation of dendritic spine developmentGO:00609999.6APOE, PSEN1
2cellular calcium ion homeostasisGO:00068749.2APOE, PSEN1
3negative regulation of protein phosphorylationGO:00019339.1PSEN1, TARDBP

Sources for Alexia

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2CDC
14ExPASy
15FDA
16FMA
24GTR
25HGMD
26HMDB
27ICD10
28ICD10 via Orphanet
29ICD9CM
30IUPHAR
31KEGG
34MedGen
36MeSH
37MESH via Orphanet
38MGI
41NCI
42NCIt
43NDF-RT
46NINDS
47Novoseek
49OMIM
50OMIM via Orphanet
54PubMed
55QIAGEN
60SNOMED-CT via Orphanet
64Tumor Gene Family of Databases
65UMLS
66UMLS via Orphanet