Aliases & Classifications for Alexia

MalaCards integrated aliases for Alexia:

Name: Alexia 12 72 14 69
Dyslexia, Acquired 41 69
Dyslexia 41 69
Acquired Dyslexia 12
Aphemesthaesia 12

Classifications:



External Ids:

Disease Ontology 12 DOID:13417
ICD9CM 34 315.01

Summaries for Alexia

Disease Ontology : 12 An agnosia that is a loss of the ability to recognize text.

MalaCards based summary : Alexia, also known as dyslexia, acquired, is related to agraphia and aphasia, and has symptoms including aprosodia and scanning speech. An important gene associated with Alexia is PSEN1 (Presenilin 1), and among its related pathways/superpathways are Neuroscience and A-beta Signaling Pathways. The drugs Rivastigmine and Cholinergic Agents have been mentioned in the context of this disorder. Affiliated tissues include brain, b cells and whole blood.

Wikipedia : 72 Dyslexia, also known as reading disorder, is characterized by trouble with reading despite normal... more...

Related Diseases for Alexia

Diseases related to Alexia via text searches within MalaCards or GeneCards Suite gene sharing:

(show top 50) (show all 86)
# Related Disease Score Top Affiliating Genes
1 agraphia 31.2 KANTR MBP PPP3CA PSEN1 TARDBP
2 aphasia 30.3 APOE PSEN1
3 visual agnosia 30.2 KANTR PSEN1
4 semantic dementia 30.1 APOE TARDBP
5 associative agnosia 29.9 PSEN1 TARDBP
6 dementia 29.9 APOE PSEN1 TARDBP
7 head injury 29.8 APOE LBR
8 alzheimer disease 28.2 APOE PPP3CA PSEN1 TARDBP
9 agnosia 11.3
10 visual verbal agnosia 10.9
11 inclusion body myopathy with early-onset paget disease and frontotemporal dementia 10.9
12 phonagnosia 10.3 PSEN1 TARDBP
13 expressive language disorder 10.3 PSEN1 TARDBP
14 alzheimer disease 4 10.2 APOE PSEN1
15 gait apraxia 10.2 APOE PSEN1
16 familial idiopathic basal ganglia calcification 10.2 APOE PSEN1
17 lethal congenital contracture syndrome 1 10.2 MBP TARDBP
18 nominal aphasia 10.2 PSEN1 TARDBP
19 oculomotor nerve paralysis 10.2 KANTR MBP
20 third cranial nerve disease 10.1 KANTR MBP
21 transient global amnesia 10.1 KANTR PSEN1
22 anterior spinal artery syndrome 10.1 KANTR MBP
23 intracranial vasospasm 10.1 APOE KANTR
24 tabes dorsalis 10.1 KANTR MBP
25 alzheimer disease 2 10.1 APOE PSEN1
26 postencephalitic parkinson disease 10.1 KANTR TARDBP
27 balo concentric sclerosis 10.1 MBP WDFY2
28 traumatic brain injury 10.1 APOE MBP
29 cerebral amyloid angiopathy, cst3-related 10.1 APOE PSEN1
30 basal ganglia disease 10.1 PSEN1 TARDBP
31 multiple sclerosis 10.0
32 prosopagnosia 10.0
33 ideomotor apraxia 10.0 MBP PSEN1 TARDBP
34 frontotemporal dementia and/or amyotrophic lateral sclerosis 1 10.0 PSEN1 TARDBP
35 accommodative esotropia 10.0 KANTR WDFY2
36 dyslexia 10.0
37 posterior cortical atrophy 10.0
38 brain injury 10.0 APOE MBP
39 internuclear ophthalmoplegia 10.0 KANTR MBP PSEN1
40 cerebritis 10.0
41 vascular dementia 10.0 APOE MBP PSEN1
42 pick disease of brain 9.9 APOE PSEN1 TARDBP
43 supranuclear palsy, progressive, 1 9.9 APOE PSEN1 TARDBP
44 dementia, lewy body 9.9 APOE PSEN1 TARDBP
45 simultanagnosia 9.9
46 frontotemporal dementia 9.8 APOE PSEN1 TARDBP
47 migraine with or without aura 1 9.8
48 complement hyperactivation, angiopathic thrombosis, and protein-losing enteropathy 9.8
49 anosognosia 9.8
50 thrombosis 9.8

Graphical network of the top 20 diseases related to Alexia:



Diseases related to Alexia

Symptoms & Phenotypes for Alexia

UMLS symptoms related to Alexia:


aprosodia, scanning speech

Drugs & Therapeutics for Alexia

Drugs for Alexia (from DrugBank, HMDB, Dgidb, PharmGKB, IUPHAR, NovoSeek, BitterDB):

(show top 50) (show all 73)
# Name Status Phase Clinical Trials Cas Number PubChem Id
1
Rivastigmine Approved, Investigational Phase 4 123441-03-2 77991
2 Cholinergic Agents Phase 4
3 Cholinesterase Inhibitors Phase 4
4 Neuroprotective Agents Phase 4,Phase 1,Phase 2
5 Neurotransmitter Agents Phase 4,Phase 3
6 Protective Agents Phase 4,Phase 1,Phase 2
7 Imatinib Mesylate Phase 4 123596
8 Protein Kinase Inhibitors Phase 4
9
Ibuprofen Approved Phase 3 15687-27-1 3672
10
Dextromethorphan Approved Phase 3 125-71-3 5362449 5360696
11
Guaifenesin Approved, Investigational, Vet_approved Phase 3 93-14-1 3516
12
Quinidine Approved, Investigational Phase 3 56-54-2 441074
13
Insulin Detemir Approved Phase 3 169148-63-4 5311023
14
Pancrelipase Approved, Investigational Phase 3 53608-75-6
15
Zinc Approved, Investigational Phase 3 7440-66-6 32051 23994
16 Anti-Inflammatory Agents Phase 3,Phase 1,Phase 2
17 Cromolyn Sodium Phase 3
18 Antitussive Agents Phase 3
19 Chlorpheniramine, phenylpropanolamine drug combination Phase 3
20 Excitatory Amino Acid Antagonists Phase 3
21 Excitatory Amino Acids Phase 3
22 Quinidine gluconate Phase 3
23 Respiratory System Agents Phase 3
24 Hypoglycemic Agents Phase 3
25 insulin Phase 3
26 Insulin, Globin Zinc Phase 3
27 Insulin, Long-Acting Phase 3
28 pancreatin Phase 3
29
Cyclophosphamide Approved, Investigational Phase 1, Phase 2 50-18-0, 6055-19-2 2907
30
Doxorubicin Approved, Investigational Phase 1, Phase 2 23214-92-8 31703
31
Methylprednisolone Approved, Vet_approved Phase 1, Phase 2 83-43-2 6741
32
Prednisolone Approved, Vet_approved Phase 1, Phase 2 50-24-8 5755
33
rituximab Approved Phase 1, Phase 2 174722-31-7 10201696
34
Vincristine Approved, Investigational Phase 1, Phase 2 2068-78-2, 57-22-7 5978
35
Etoposide Approved Phase 1, Phase 2 33419-42-0 36462
36
Ifosfamide Approved Phase 1, Phase 2 3778-73-2 3690
37
Mechlorethamine Approved, Investigational Phase 1, Phase 2 51-75-2 4033
38
Doxil Approved June 1999 Phase 1, Phase 2 31703
39 Alkylating Agents Phase 1, Phase 2
40 Anti-Bacterial Agents Phase 1, Phase 2
41 Antibiotics, Antitubercular Phase 1, Phase 2
42 Antiemetics Phase 1, Phase 2
43 Antimitotic Agents Phase 1, Phase 2
44 Antineoplastic Agents, Hormonal Phase 1, Phase 2
45 Antineoplastic Agents, Phytogenic Phase 1, Phase 2
46 Antirheumatic Agents Phase 1, Phase 2
47 Autonomic Agents Phase 1, Phase 2
48 Gastrointestinal Agents Phase 1, Phase 2
49 glucocorticoids Phase 1, Phase 2
50 Hormone Antagonists Phase 1, Phase 2

Interventional clinical trials:

(show all 22)

# Name Status NCT ID Phase Drugs
1 Effects of Rivastigmine Patch on Activities of Daily Living and Cognition in Patients With Severe Dementia of the Alzheimer's Type (ACTION) (Study Protocol CENA713DUS44, NCT00948766) and a 24 Week Open-label Extension to Study CENA713DUS44 Completed NCT00948766 Phase 4 Rivastigmine 4.6 mg/24 h (5 cm^2);Rivastigmine 9.5 mg/24 h (10 cm^2);Rivastigmine 13.3 mg/24 h (15 cm^2);Placebo
2 Chemotherapy and Imatinib in Young Adults With Acute Lymphoblastic Leukemia Ph (BCR-ABL) POSITIVE Recruiting NCT01491763 Phase 4 Imatinib
3 Safety and Efficacy Study of ALZT-OP1 in Subjects With Evidence of Early Alzheimer's Disease Recruiting NCT02547818 Phase 3 ALZT-OP1a;ALZT-OP1b
4 Long Term, Extension Study of the Safety and Efficacy of AVP-786 for the Treatment of Agitation in Patients With Dementia of the Alzheimer's Type Recruiting NCT02446132 Phase 3 AVP-786
5 Efficacy, Safety, and Tolerability of AVP-786 for the Treatment of Agitation in Patients With Dementia of the Alzheimer's Type Recruiting NCT02442778 Phase 3 AVP-786;Placebo
6 Cystic Fibrosis - Insulin Deficiency, Early Action Recruiting NCT01100892 Phase 3 Once-daily insulin detemir
7 Study of Tazemetostat in Newly Diagnosed Diffuse Large B Cell Lymphoma Patients Treated by Chemiotherapy Recruiting NCT02889523 Phase 1, Phase 2 Tazemetostat;Rituximab;Cyclophosphamide;Vincristine;Doxorubicin;Prednisolone
8 Brentuximab Vedotin in Refractory/Relapsed Hodgkin Lymphoma Treated by ICE Recruiting NCT02686346 Phase 1, Phase 2 Brentuximab Vedotin;Etoposide;Carboplatine;Ifosfamide
9 Treatments of the Necrosed Immature Teeth (REV) Recruiting NCT02064517 Phase 2
10 Phase II Trial of Seizure Prophylaxis in Suspected Primary Glioma Patients Undergoing Craniotomy Not yet recruiting NCT03436433 Phase 2 Lacosamide;Levetiracetam
11 Brain Mechanisms Underlying Reading Improvement in Central Alexia Completed NCT02062619
12 Multimodal Treatment of Phonological Alexia: Behavioral & fMRI Outcomes Completed NCT00827268
13 Toxin Retrospective Study Completed NCT03042052 detrusor infection of Botulinum toxin
14 Therapy for Reading Problems in Adults After Brain Injury Completed NCT00064805
15 App-delivered Therapy for Arabic Readers With Hemianopic Alexia Recruiting NCT02482350
16 On-Q Catheter Caregiver Education Recruiting NCT03372889
17 Initiating and Maintaining Physical Activity in Depressed Individuals Recruiting NCT02691845
18 Analysis of Natural Killer Cell Activity (NKA) in Whole Blood in High Risk Subjects Undergoing Colonoscopy Recruiting NCT03249727
19 Preoperative Treatment With Noninvasive Intra-auricular Vagus Nerve Stimulation Pending Bariatric Surgery Recruiting NCT02648191
20 WallFlex Pancreatic Metal Stent for Pancreatic Duct Strictures Recruiting NCT02802020
21 Transcutaneous Electrical Nerve Stimulation (TENS) for Lower Urinary Tract Disorders in Parkinson's Syndrome Recruiting NCT02190851
22 AMPLATZER™ Amulet™ LAA Occluder Trial Recruiting NCT02879448

Search NIH Clinical Center for Alexia

Cochrane evidence based reviews: dyslexia

Genetic Tests for Alexia

Anatomical Context for Alexia

MalaCards organs/tissues related to Alexia:

38
Brain, B Cells, Whole Blood, Bone, Eye, Temporal Lobe, Parietal Lobe

Publications for Alexia

Articles related to Alexia:

(show top 50) (show all 331)
# Title Authors Year
1
Pure alexia: two cases and a new neuroanatomical classification. ( 29181626 )
2018
2
The neural substrates of improved phonological processing following successful treatment in a case of phonological alexia and agraphia. ( 29350575 )
2018
3
A formal analysis of alexia in persistent aura and a comparison to acquired pure alexia. ( 28376693 )
2017
4
Reading on the right when there's nothing left? Probabilistic tractography reveals hemispheric asymmetry in pure alexia. ( 28789579 )
2017
5
Multi-step treatment for acquired alexia and agraphia (part II): a dual-route error scoring system. ( 28421910 )
2017
6
Alexia Without Agraphia: A Rare Entity. ( 28690938 )
2017
7
Face perception in pure alexia: Complementary contributions of the left fusiform gyrus to facial identity and facial speech processing. ( 28964939 )
2017
8
Prosopometamorphopsia and alexia following left splenial corpus callosum infarction: Case report and literature review. ( 29260005 )
2017
9
Multi-step treatment for acquired alexia and agraphia (Part I): efficacy, generalisation, and identification of beneficial treatment steps. ( 28421858 )
2017
10
Glioblastoma Presenting with Pure Alexia and Palinopsia Involving the Left Inferior Occipital Gyrus and Visual Word Form Area Evaluated with Functional Magnetic Resonance Imaging and Diffusion Tensor Imaging Tractography. ( 26748167 )
2016
11
Brain pathology case of the month August 2016 - case 2 A 71 year old man presenting with headache, blurry vision and alexia without agraphia. ( 27647576 )
2016
12
Pure alexia in a patient with multiple sclerosis. ( 27770273 )
2016
13
Clinical Communication in Medicine Brown Jo Noble Lorraine M Papageorgiou Alexia Kidd Jane Clinical Communication in Medicine 280pp AL34.99 Wiley Blackwell 9781118728246 1118728246 [Formula: see text]. ( 27406511 )
2016
14
Visual attention in posterior stroke and relations to alexia. ( 26970141 )
2016
15
Acquired dyslexia in Serbian speakers with Broca's and Wernicke's aphasia. ( 27135368 )
2016
16
Brain mechanisms of recovery from pure alexia: A single case study with multiple longitudinal scans. ( 27422538 )
2016
17
Untangling letter confusability and word length effects in pure alexia. ( 26745321 )
2016
18
Transcranial direct current stimulation for pure alexia: effects on brain and behavior. ( 25511797 )
2015
19
Treatment for Alexia With Agraphia Following Left Ventral Occipito-Temporal Damage: Strengthening Orthographic Representations Common to Reading and Spelling. ( 26110814 )
2015
20
A case of pure alexia and foreign accent syndrome following acute encephalopathy in the presence of anti-glutamate receptor antibodies. ( 26289758 )
2015
21
The effects of homonymous hemianopia in experimental studies of alexia. ( 25708175 )
2015
22
Successful remote delivery of a treatment for phonological alexia via telerehab. ( 26018197 )
2015
23
Double Disassociation of Anosognosia for Alexia and Simultanagnosia but Quantitative Awareness of Optic Ataxia. ( 26368835 )
2015
24
Alexia Without Agraphia in a Right-Handed Individual Following Right Occipital Stroke. ( 26397830 )
2015
25
Vanishing splenial lesion presenting as alexia with dysgraphia. ( 25683766 )
2015
26
Behavioural and eye-movement outcomes in response to text-based reading treatment for acquired alexia. ( 25582781 )
2015
27
Progressive Wallerian Degeneration of the Corpus Callosal Splenium in a Patient with Alexia Without Agraphia: Advanced MR Findings. ( 25489886 )
2014
28
Effects of intensive phonomotor treatment on reading in eight individuals with aphasia and phonological alexia. ( 24686537 )
2014
29
On compensatory strategies and computational models: the case of pure alexia. ( 24863010 )
2014
30
Pure alexia after damage to the right fusiform gyrus in a right-handed male. ( 25440018 )
2014
31
Right Brain: A reading specialist with alexia without agraphia: Teacher interrupted. ( 24379102 )
2014
32
Reading faces: Investigating the use of a novel face-based orthography in acquired alexia. ( 24463310 )
2014
33
What lies beneath: a comparison of reading aloud in pure alexia and semantic dementia. ( 24702272 )
2014
34
What's in a name? The characterization of pure alexia. ( 25051117 )
2014
35
Is Radical-by-Radical Reading Strategy Effective for Chinese Pure Alexia? A Case Study. ( 25068672 )
2014
36
Posterior cerebral artery stroke presenting as alexia without agraphia. ( 24935413 )
2014
37
Connectionist neuropsychology: uncovering ultimate causes of acquired dyslexia. ( 24324241 )
2014
38
Alexia due to ischemic stroke of the visual word form area. ( 23528139 )
2014
39
Fast word reading in pure alexia: "fast, yet serial" ( 24592898 )
2014
40
An eye movement study on the role of the visual field defect in pure alexia. ( 24999811 )
2014
41
From word superiority to word inferiority: visual processing of letters and words in pure alexia. ( 24801564 )
2014
42
Fluorodeoxyglucose F18 positron emission tomography in a case of slowly progressive pure alexia. ( 23998338 )
2013
43
Rehabilitation of pure alexia: a review. ( 23808895 )
2013
44
Bilateral Hemispheric Processing of Words and Faces: Evidence from Word Impairments in Prosopagnosia and Face Impairments in Pure Alexia. ( 23250954 )
2013
45
How low can you go: spatial frequency sensitivity in a patient with pure alexia. ( 23774289 )
2013
46
Word-superiority in pure alexia. ( 22713414 )
2013
47
Temporal recruitment of cortical network involved in reading epilepsy with paroxysmal alexia: a combined EEG/MEG study. ( 23287492 )
2013
48
Reading therapy strengthens top-down connectivity in patients with pure alexia. ( 23884814 )
2013
49
Dysfunctional visual word form processing in progressive alexia. ( 23471694 )
2013
50
Left- and right-hemisphere forms of phonological alexia. ( 23521052 )
2012

Variations for Alexia

Expression for Alexia

Search GEO for disease gene expression data for Alexia.

Pathways for Alexia

Pathways related to Alexia according to GeneCards Suite gene sharing:

# Super pathways Score Top Affiliating Genes
1 11.46 APOE MBP PSEN1 TARDBP
2 10.9 PPP3CA PSEN1
3 10.61 APOE PSEN1

GO Terms for Alexia

Cellular components related to Alexia according to GeneCards Suite gene sharing:

# Name GO ID Score Top Affiliating Genes
1 neuronal cell body GO:0043025 8.8 APOE MBP PSEN1

Biological processes related to Alexia according to GeneCards Suite gene sharing:

# Name GO ID Score Top Affiliating Genes
1 negative regulation of protein phosphorylation GO:0001933 9.32 PSEN1 TARDBP
2 positive regulation of dendritic spine development GO:0060999 9.26 APOE PSEN1
3 positive regulation of endocytosis GO:0045807 9.16 APOE PPP3CA
4 amyloid precursor protein metabolic process GO:0042982 8.96 APOE PSEN1
5 positive regulation of amyloid fibril formation GO:1905908 8.62 APOE PSEN1

Sources for Alexia

3 CDC
7 CNVD
9 Cosmic
10 dbSNP
11 DGIdb
16 ExPASy
18 FMA
27 GO
28 GTR
29 HGMD
30 HMDB
31 HPO
32 ICD10
33 ICD10 via Orphanet
34 ICD9CM
35 IUPHAR
36 KEGG
37 LifeMap
39 MedGen
41 MeSH
42 MESH via Orphanet
43 MGI
45 NCI
46 NCIt
47 NDF-RT
50 NINDS
51 Novoseek
53 OMIM
54 OMIM via Orphanet
58 PubMed
60 QIAGEN
65 SNOMED-CT via HPO
66 SNOMED-CT via Orphanet
67 TGDB
68 Tocris
69 UMLS
70 UMLS via Orphanet
Content
Loading form....