Aliases & Classifications for Alexia

Aliases & Descriptions for Alexia:

Name: Alexia 12 14 69
Dyslexia, Acquired 42 69
Dyslexia 42 69
Acquired Dyslexia 12
Aphemesthaesia 12

Classifications:



External Ids:

Disease Ontology 12 DOID:13417
ICD9CM 35 315.01

Summaries for Alexia

Disease Ontology : 12 An agnosia that is a loss of the ability to recognize text.

MalaCards based summary : Alexia, also known as dyslexia, acquired, is related to agraphia and agnosia, and has symptoms including scanning speech and aprosodia. An important gene associated with Alexia is PSEN1 (Presenilin 1), and among its related pathways/superpathways are Neuroscience and A-beta Signaling Pathways. The drugs Rivastigmine and Cholinergic Agents have been mentioned in the context of this disorder. Affiliated tissues include brain, eye and temporal lobe, and related phenotype is hematopoietic system.

Related Diseases for Alexia

Diseases related to Alexia via text searches within MalaCards or GeneCards Suite gene sharing:

(show top 50) (show all 86)
id Related Disease Score Top Affiliating Genes
1 agraphia 11.3
2 agnosia 11.2
3 dyslexia 11.2
4 visual verbal agnosia 10.8
5 social emotional agnosia 10.2 PSEN1 TARDBP
6 color agnosia 10.2 PSEN1 TARDBP
7 cerebral arteritis 10.2 PSEN1 TARDBP
8 autoimmune disease of blood 10.2 PSEN1 TARDBP
9 aphasia 10.2
10 encephalitozoonosis 10.2 APOE PSEN1
11 spastic ataxia 7, autosomal dominant 10.2 KANTR LBR
12 andersen syndrome 10.2 PSEN1 TARDBP
13 keratoconus 6 10.2 MBP TARDBP
14 acquired metabolic disease 10.2 KANTR PSEN1
15 immune-mediated encephalomyelitis 10.1 APOE LBR
16 relapsing fever 10.1 KANTR PSEN1
17 acute serous otitis media 10.1 KANTR MBP
18 limited scleroderma 10.1 APOE PSEN1
19 ampulla of vater adenosquamous carcinoma 10.1 KANTR MBP
20 pediatric mesenchymal chondrosarcoma 10.1 PSEN1 TARDBP
21 schwannoma of jugular foramen 10.1 KANTR MBP
22 mechanical entropion 10.1 APOE KANTR
23 compensatory emphysema 10.1 KANTR MBP
24 adult mesenchymal chondrosarcoma 10.1 PSEN1 TARDBP
25 meckel syndrome 10 10.1 APOE PSEN1
26 crest syndrome 10.1 MBP WDFY2
27 riedel's fibrosing thyroiditis 10.1 KANTR TARDBP
28 hypolipoproteinemia 10.1 KANTR MBP
29 pancreatic cancer/melanoma syndrome 10.1 PSEN1 TARDBP
30 urea cycle disorder 10.1 APOE MBP
31 postauricular lymphadenitis 10.1 MBP PSEN1 TARDBP
32 interstitial keratitis 10.1 KANTR WDFY2
33 clear cell adenoma 10.0 KANTR MBP PSEN1
34 polyneuropathy, hearing loss, ataxia, retinitis pigmentosa, and cataract 10.0 APOE PSEN1
35 contagious pustular dermatitis 10.0 APOE MBP PSEN1
36 severe congenital nemaline myopathy 10.0 APOE PSEN1 TARDBP
37 pancreatic solid pseudopapillary carcinoma 10.0 PSEN1 TARDBP
38 autoimmune disease of urogenital tract 10.0 APOE PSEN1 TARDBP
39 coenzyme q10 deficiency, primary, 1 10.0 APOE PSEN1 TARDBP
40 cardiomyopathy, dilated, 1u 10.0 APOE PSEN1 TARDBP
41 breast reconstruction 10.0 APOE MBP
42 eumycotic mycetoma 10.0 APOE PSEN1 TARDBP
43 dementia 10.0
44 prosopagnosia 10.0
45 posterior cortical atrophy 9.9
46 nerve fibre bundle defect 9.9 KANTR MBP
47 semantic dementia 9.9
48 cerebritis 9.9
49 visual agnosia 9.9
50 acne inversa, familial, 3 9.9 APOE MBP PSEN1 TARDBP

Graphical network of the top 20 diseases related to Alexia:



Diseases related to Alexia

Symptoms & Phenotypes for Alexia

UMLS symptoms related to Alexia:


scanning speech, aprosodia

MGI Mouse Phenotypes related to Alexia:

44
id Description MGI Source Accession Score Top Affiliating Genes
1 hematopoietic system MP:0005397 9.1 APOE LBR MBP PPP3CA PSEN1 TARDBP

Drugs & Therapeutics for Alexia

Drugs for Alexia (from DrugBank, HMDB, Dgidb, PharmGKB, IUPHAR, NovoSeek, BitterDB):

(show top 50) (show all 70)
id Name Status Phase Clinical Trials Cas Number PubChem Id
1
Rivastigmine Approved, Investigational Phase 4 123441-03-2 77991
2 Cholinergic Agents Phase 4
3 Cholinesterase Inhibitors Phase 4
4 Neuroprotective Agents Phase 4,Phase 1,Phase 2
5 Neurotransmitter Agents Phase 4
6 Protective Agents Phase 4,Phase 1,Phase 2
7 Imatinib Mesylate Phase 4 123596
8 Protein Kinase Inhibitors Phase 4
9
Ibuprofen Approved Phase 3 15687-27-1 3672
10
Insulin Detemir Approved Phase 3 169148-63-4 5311023
11
Pancrelipase Approved Phase 3 53608-75-6
12
Zinc Approved Phase 3 7440-66-6 32051 23994
13
Cyclophosphamide Approved, Investigational Phase 3,Phase 1,Phase 2 50-18-0, 6055-19-2 2907
14
Doxorubicin Approved, Investigational Phase 3,Phase 1,Phase 2 23214-92-8 31703
15
Lenalidomide Approved Phase 3 191732-72-6 216326
16
Prednisone Approved, Vet_approved Phase 3 53-03-2 5865
17
rituximab Approved Phase 3,Phase 1,Phase 2 174722-31-7 10201696
18
Vincristine Approved, Investigational Phase 3,Phase 1,Phase 2 2068-78-2, 57-22-7 5978
19
Doxil Approved June 1999 Phase 3,Phase 1,Phase 2 31703
20 Anti-Inflammatory Agents Phase 3,Phase 1,Phase 2
21 Cromolyn Sodium Phase 3
22 Hypoglycemic Agents Phase 3
23 insulin Phase 3
24 Insulin, Globin Zinc Phase 3
25 Insulin, Long-Acting Phase 3
26 pancreatin Phase 3
27 Angiogenesis Inhibitors Phase 3
28 Angiogenesis Modulating Agents Phase 3
29 Anti-Bacterial Agents Phase 3,Phase 1,Phase 2
30 Anti-Infective Agents Phase 3
31 Antirheumatic Agents Phase 3,Phase 1,Phase 2
32 Immunosuppressive Agents Phase 3,Phase 1,Phase 2
33
Methylprednisolone Approved, Vet_approved Phase 1, Phase 2 83-43-2 6741
34
Prednisolone Approved, Vet_approved Phase 1, Phase 2 50-24-8 5755
35
Etoposide Approved Phase 1, Phase 2 33419-42-0 36462
36
Ifosfamide Approved Phase 1, Phase 2 3778-73-2 3690
37
Mechlorethamine Approved Phase 1, Phase 2 51-75-2 4033
38 Alkylating Agents Phase 1, Phase 2
39 Antibiotics, Antitubercular Phase 1, Phase 2
40 Antiemetics Phase 1, Phase 2
41 Antimitotic Agents Phase 1, Phase 2
42 Antineoplastic Agents, Alkylating Phase 1, Phase 2
43 Antineoplastic Agents, Hormonal Phase 1, Phase 2
44 Antineoplastic Agents, Phytogenic Phase 1, Phase 2
45 Autonomic Agents Phase 1, Phase 2
46 Gastrointestinal Agents Phase 1, Phase 2
47 glucocorticoids Phase 1, Phase 2
48 Hormone Antagonists Phase 1, Phase 2
49 Hormones Phase 1, Phase 2
50 Hormones, Hormone Substitutes, and Hormone Antagonists Phase 1, Phase 2

Interventional clinical trials:

(show all 18)
id Name Status NCT ID Phase
1 Effects of Rivastigmine Patch on Activities of Daily Living and Cognition in Patients With Severe Dementia of the Alzheimer's Type (ACTION) (Study Protocol CENA713DUS44, NCT00948766) and a 24 Week Open-label Extension to Study CENA713DUS44 Completed NCT00948766 Phase 4
2 Chemotherapy and Imatinib in Young Adults With Acute Lymphoblastic Leukemia Ph (BCR-ABL) POSITIVE Recruiting NCT01491763 Phase 4
3 Safety and Efficacy Study of ALZT-OP1 in Subjects With Evidence of Early Alzheimer's Disease Recruiting NCT02547818 Phase 3
4 Cystic Fibrosis - Insulin Deficiency, Early Action Recruiting NCT01100892 Phase 3
5 Efficacy of Lenalidomide in Combination With Subcutaneous Rituximab + miniCHOP in DLBCL Patients of 80 y/o or+ Recruiting NCT02128061 Phase 3
6 Multimodal Treatment of Phonological Alexia: Behavioral & fMRI Outcomes Completed NCT00827268 Phase 1, Phase 2
7 Study of Tazemetostat in Newly Diagnosed Diffuse Large B Cell Lymphoma Patients Treated by Chemiotherapy Recruiting NCT02889523 Phase 1, Phase 2
8 Brentuximab Vedotin in Refractory/Relapsed Hodgkin Lymphoma Treated by ICE Recruiting NCT02686346 Phase 1, Phase 2
9 Treatments of the Necrosed Immature Teeth (REV) Recruiting NCT02064517 Phase 2
10 Effects of Music Education for Children With Reading Difficulties Unknown status NCT01388881
11 Therapy for Reading Problems in Adults After Brain Injury Completed NCT00064805
12 Brain Mechanisms Underlying Reading Improvement in Central Alexia Completed NCT02062619
13 Toxin Retrospective Study Completed NCT03042052
14 Initiating and Maintaining Physical Activity in Depressed Individuals Recruiting NCT02691845
15 Preoperative Treatment With Noninvasive Intra-auricular Vagus Nerve Stimulation Pending Bariatric Surgery Recruiting NCT02648191
16 WallFlex Pancreatic Metal Stent for Pancreatic Duct Strictures Recruiting NCT02802020
17 AMPLATZER™ Amulet™ LAA Occluder Trial Recruiting NCT02879448
18 App-delivered Therapy for Arabic Readers With Hemianopic Alexia Not yet recruiting NCT02482350

Search NIH Clinical Center for Alexia

Cochrane evidence based reviews: dyslexia

Genetic Tests for Alexia

Anatomical Context for Alexia

MalaCards organs/tissues related to Alexia:

39
Brain, Eye, Temporal Lobe, Parietal Lobe, Cortex, Occipital Lobe, Testes

Publications for Alexia

Articles related to Alexia:

(show top 50) (show all 313)
id Title Authors Year
1
Brain pathology case of the month August 2016 - case 2 A 71 year old man presenting with headache, blurry vision and alexia without agraphia. ( 27647576 )
2016
2
Pure alexia in a patient with multiple sclerosis. ( 27770273 )
2016
3
Brain mechanisms of recovery from pure alexia: A single case study with multiple longitudinal scans. ( 27422538 )
2016
4
Untangling letter confusability and word length effects in pure alexia. ( 26745321 )
2016
5
Glioblastoma Presenting with Pure Alexia and Palinopsia Involving the Left Inferior Occipital Gyrus and Visual Word Form Area Evaluated with Functional Magnetic Resonance Imaging and Diffusion Tensor Imaging Tractography. ( 26748167 )
2016
6
Visual attention in posterior stroke and relations to alexia. ( 26970141 )
2016
7
Clinical Communication in Medicine Brown Jo Noble Lorraine M Papageorgiou Alexia Kidd Jane Clinical Communication in Medicine 280pp AL34.99 Wiley Blackwell 9781118728246 1118728246 [Formula: see text]. ( 27406511 )
2016
8
A case of pure alexia and foreign accent syndrome following acute encephalopathy in the presence of anti-glutamate receptor antibodies. ( 26289758 )
2015
9
Successful remote delivery of a treatment for phonological alexia via telerehab. ( 26018197 )
2015
10
Treatment for Alexia With Agraphia Following Left Ventral Occipito-Temporal Damage: Strengthening Orthographic Representations Common to Reading and Spelling. ( 26110814 )
2015
11
The effects of homonymous hemianopia in experimental studies of alexia. ( 25708175 )
2015
12
Alexia Without Agraphia in a Right-Handed Individual Following Right Occipital Stroke. ( 26397830 )
2015
13
Behavioural and eye-movement outcomes in response to text-based reading treatment for acquired alexia. ( 25582781 )
2015
14
Transcranial direct current stimulation for pure alexia: effects on brain and behavior. ( 25511797 )
2015
15
Double Disassociation of Anosognosia for Alexia and Simultanagnosia but Quantitative Awareness of Optic Ataxia. ( 26368835 )
2015
16
Vanishing splenial lesion presenting as alexia with dysgraphia. ( 25683766 )
2015
17
What's in a name? The characterization of pure alexia. ( 25051117 )
2014
18
Right Brain: A reading specialist with alexia without agraphia: Teacher interrupted. ( 24379102 )
2014
19
Alexia due to ischemic stroke of the visual word form area. ( 23528139 )
2014
20
An eye movement study on the role of the visual field defect in pure alexia. ( 24999811 )
2014
21
Is Radical-by-Radical Reading Strategy Effective for Chinese Pure Alexia? A Case Study. ( 25068672 )
2014
22
Effects of intensive phonomotor treatment on reading in eight individuals with aphasia and phonological alexia. ( 24686537 )
2014
23
Progressive Wallerian Degeneration of the Corpus Callosal Splenium in a Patient with Alexia Without Agraphia: Advanced MR Findings. ( 25489886 )
2014
24
Fast word reading in pure alexia: "fast, yet serial" ( 24592898 )
2014
25
Posterior cerebral artery stroke presenting as alexia without agraphia. ( 24935413 )
2014
26
What lies beneath: a comparison of reading aloud in pure alexia and semantic dementia. ( 24702272 )
2014
27
From word superiority to word inferiority: visual processing of letters and words in pure alexia. ( 24801564 )
2014
28
Reading faces: Investigating the use of a novel face-based orthography in acquired alexia. ( 24463310 )
2014
29
Pure alexia after damage to the right fusiform gyrus in a right-handed male. ( 25440018 )
2014
30
On compensatory strategies and computational models: the case of pure alexia. ( 24863010 )
2014
31
Word-superiority in pure alexia. ( 22713414 )
2013
32
How low can you go: spatial frequency sensitivity in a patient with pure alexia. ( 23774289 )
2013
33
Reading therapy strengthens top-down connectivity in patients with pure alexia. ( 23884814 )
2013
34
Rehabilitation of pure alexia: a review. ( 23808895 )
2013
35
Dysfunctional visual word form processing in progressive alexia. ( 23471694 )
2013
36
Fluorodeoxyglucose F18 positron emission tomography in a case of slowly progressive pure alexia. ( 23998338 )
2013
37
Temporal recruitment of cortical network involved in reading epilepsy with paroxysmal alexia: a combined EEG/MEG study. ( 23287492 )
2013
38
Bilateral Hemispheric Processing of Words and Faces: Evidence from Word Impairments in Prosopagnosia and Face Impairments in Pure Alexia. ( 23250954 )
2013
39
Thalamic alexia with agraphia. ( 22593808 )
2012
40
Preserved visual language identification despite severe alexia. ( 22401988 )
2012
41
The word-length effect in acquired alexia, and real and virtual hemianopia. ( 22326623 )
2012
42
Left- and right-hemisphere forms of phonological alexia. ( 23521052 )
2012
43
Covert reading of letters in a case of global alexia. ( 22277310 )
2012
44
Do patients with pure alexia suffer from a specific word form processing deficit? Evidence from 'wrods with trasnpsoed letetrs'. ( 21236271 )
2011
45
Age-of-acquisition effects in pure alexia. ( 21424984 )
2011
46
"Seeing but not identifying": pure alexia coincident with prosopagnosia in occipital arteriovenous malformation. ( 21243372 )
2011
47
Number reading in pure alexia--a review. ( 21554892 )
2011
48
Multimodal alexia: neuropsychological mechanisms and implications for treatment. ( 21952194 )
2011
49
Temporal lobe epilepsy manifesting as alexia with agraphia for kanji. ( 21907629 )
2011
50
Posterior cortical atrophy with prominent alexia without agraphia in a Tourette syndrome. ( 21912890 )
2011

Variations for Alexia

Expression for Alexia

Search GEO for disease gene expression data for Alexia.

Pathways for Alexia

Pathways related to Alexia according to GeneCards Suite gene sharing:

id Super pathways Score Top Affiliating Genes
1 11.43 APOE MBP PSEN1 TARDBP
2 10.93 PPP3CA PSEN1
3 10.61 APOE PSEN1

GO Terms for Alexia

Cellular components related to Alexia according to GeneCards Suite gene sharing:

id Name GO ID Score Top Affiliating Genes
1 neuronal cell body GO:0043025 8.8 APOE MBP PSEN1

Biological processes related to Alexia according to GeneCards Suite gene sharing:

id Name GO ID Score Top Affiliating Genes
1 negative regulation of protein phosphorylation GO:0001933 9.16 PSEN1 TARDBP
2 positive regulation of dendritic spine development GO:0060999 8.96 APOE PSEN1
3 amyloid precursor protein metabolic process GO:0042982 8.62 APOE PSEN1

Sources for Alexia

3 CDC
7 CNVD
9 Cosmic
10 dbSNP
11 DGIdb
16 ExPASy
18 FMA
28 GO
29 GTR
30 HGMD
31 HMDB
32 HPO
33 ICD10
34 ICD10 via Orphanet
35 ICD9CM
36 IUPHAR
37 KEGG
38 LifeMap
40 MedGen
42 MeSH
43 MESH via Orphanet
44 MGI
46 NCI
47 NCIt
48 NDF-RT
51 NINDS
52 Novoseek
54 OMIM
55 OMIM via Orphanet
59 PubMed
60 QIAGEN
65 SNOMED-CT via Orphanet
67 TGDB
68 Tocris
69 UMLS
70 UMLS via Orphanet
Content
Loading form....