MCID: ALX001
MIFTS: 54

Alexia malady

Summaries for Alexia

About this section
Sources:
8Disease Ontology, 32MalaCards
See all sources

Fully expand this MalaCard

Export this MalaCard
Disease Ontology:8 An agnosia that is a loss of the ability to recognize text.

MalaCards: Alexia, also known as dyslexia, acquired, is related to meningioma and alzheimer's disease. An important gene associated with Alexia is LAT (linker for activation of T cells), and among its related pathways are p70S6K Signaling and TP53 network. The compounds cycloheximide and ag 1024 have been mentioned in the context of this disorder. Affiliated tissues include brain, temporal lobe and parietal lobe, and related mouse phenotypes are renal/urinary system and endocrine/exocrine gland.

Aliases & Classifications for Alexia

About this section
Sources:
8Disease Ontology, 60UMLS, 56SNOMED-CT, 34MeSH, 27ICD9CM
See all sources

Aliases & Descriptions:

alexia 8 60
dyslexia, acquired 60
acquired dyslexia 8
aphemesthaesia 8


External Ids:

Disease Ontology8 DOID:13417
MeSH34 D004410
ICD9CM27 315.01

Related Diseases for Alexia

About this section
Sources:
17GeneCards, 18GeneDecks
See all sources

Diseases related to Alexia via text searches within MalaCards or GeneCards/GeneDecks gene sharing:

(show top 50)    (show all 123)
idRelated DiseaseScoreTop Affiliating Genes
1meningioma29.8CTSD, IGF2, PLCG1, TP73
2alzheimer's disease29.8PDP1, CTSD, AKT1, ABL1, PLCG1, FYN
3aphasia10.5
4agnosia10.4
5visual agnosia10.4
6dysgraphia10.3
7prosopagnosia10.3
8dyslexia10.2
9dementia10.2
10multiple sclerosis10.2
11cerebritis10.1
12status epilepticus10.0
13form agnosia10.0
14simultanagnosia10.0
15associative agnosia10.0
16acute disseminated encephalomyelitis10.0
17encephalitis10.0
18encephalomyelitis10.0
19migraine10.0
20neuroblastoma10.0AKT1
21sarcoma10.0IGF2
22rhabdoid tumor10.0IGF2
23hepatoblastoma10.0IGF2
24cystic fibrosis10.0PDP1
25vascular disease10.0AKT1
26hepatitis10.0PARP1
27cervical squamous cell carcinoma10.0TP73
28fanconi's anemia10.0PARP1
29fetal macrosomia10.0IGF2
30pertussis10.0PARP1
31hyperprolactinemia10.0IGF1
32hypertension10.0IGF1
33cervical adenocarcinoma10.0PARP1
34osteoarthritis10.0IGF1
35endometrial carcinoma10.0CTSD, AKT1
36laryngeal squamous cell carcinoma10.0TP73, CTSD
37werner syndrome10.0PARP1
38oral cancer10.0PARP1, TP73
39gastrointestinal stromal tumor10.0ABL1
40chondrosarcoma10.0ABL1
41multiple myeloma10.0IGF1, AKT1
42pituitary adenoma10.0TP73, IGF1
43rheumatoid arthritis10.0AKT1, FAS
44deficiency anemia10.0ABL1
45fibrosarcoma10.0FYN, AKT1
46galactosemia10.0IGF1
47insulin-like growth factor 1 resistance to10.0IGF1, IGF2
48astrocytoma10.0AKT1, PLCG1, TP73
49hepatitis c10.0FYN, FAS
50hyperandrogenism10.0IGF2, IGF1

Graphical network of the top 20 diseases related to Alexia:



Diseases related to alexia

Clinical Features for Alexia

About this section

Drugs & Therapeutics for Alexia

About this section
Sources:
5CenterWatch, 41NIH Clinical Center, 6ClinicalTrials
See all sources

Approved drugs:

Search CenterWatch for Alexia

Drug clinical trials:

Search ClinicalTrials for Alexia

Search NIH Clinical Center for Alexia

Search CenterWatch for Alexia

Genetic Tests for Alexia

About this section

Anatomical Context for Alexia

About this section
Sources:
32MalaCards
See all sources

MalaCards organs/tissues related to Alexia:

32
Brain, Temporal lobe, Parietal lobe, Eye, Cortex, Occipital lobe, Testes

Animal Models for Alexia or affiliated genes

About this section
Sources:
36MGI
See all sources

Publications for Alexia

About this section
Sources:
50PubMed
See all sources

Articles related to Alexia:

(show top 50)    (show all 285)
idTitleAuthorsYear
1
Alexia due to ischemic stroke of the visual word form area. (23528139)
2014
2
Temporal recruitment of cortical network involved in reading epilepsy with paroxysmal alexia: a combined EEG/MEG study. (23287492)
2013
3
Word-superiority in pure alexia. (22713414)
2013
4
Thalamic alexia with agraphia. (22593808)
2012
5
The word-length effect in acquired alexia, and real and virtual hemianopia. (22326623)
2012
6
Do patients with pure alexia suffer from a specific word form processing deficit? Evidence from 'wrods with trasnpsoed letetrs'. (21236271)
2011
7
Improved single-letter identification after whole-word training in pure alexia. (19191066)
2009
8
About the role of visual field defects in pure alexia. (19498088)
2009
9
Jean Langlais (1907-91): an historical case of a blind organist with stroke-induced aphasia and Braille alexia but without amusia. (18952998)
2008
10
Evidence for a basal temporal visual language center: cortical stimulation producing pure alexia. (19001252)
2008
11
Sigmoid sinus thrombosis presenting with posterior alexia in a patient with BehAset's disease and polycythaemia: a case report. (18500981)
2008
12
Do dual-route models accurately predict reading and spelling performance in individuals with acquired alexia and agraphia? (17482218)
2007
13
Top-down and bottom-up effects in pure alexia: evidence from eye movements. (17433379)
2007
14
Training phonological reading in deep alexia: does it improve reading words with low imageability? (17468994)
2007
15
Selective alexia and agraphia sparing numbers-a case study. (17083972)
2007
16
Qualitatively different forms of pure alexia. (18416498)
2007
17
Structural anatomy of pure and hemianopic alexia. (16801352)
2006
18
Alexia without agraphia in multiple sclerosis: case report with magnetic resonance imaging localization. (15584497)
2004
19
Visual command hallucinations in a patient with pure alexia. (14707313)
2004
20
Implicit recognition in pure alexia: The Saffran effect-a tale of two systems or two procedures? (21038213)
2004
21
Pure alexia and hemianopia related to dissection of the internal carotid artery. (12499728)
2003
22
Alexia and related reading disorders. (12916491)
2003
23
Words are more than the sum of their parts: evidence for detrimental effects of word-level information in alexia. (20957559)
2002
24
Posterior alexia after right occipitotemporal infarction. (11336035)
2001
25
Pure alexia from a posterior occipital lesion. (11274315)
2001
26
Calculating without reading: unsuspected residual abilities in pure alexia. (20945195)
2000
27
Can treatment for pure alexia improve letter-by-letter reading speed without sacrificing accuracy? (10210630)
1999
28
Pure alexia and word-meaning deafness in a patient with multiple sclerosis. (9823833)
1998
29
Alexia without agraphia in multiple sclerosis. (8937353)
1996
30
Visual word activation in pure alexia. (7788347)
1995
31
Pure alexia without agraphia: a classical cortical syndrome revisited. (8778983)
1994
32
Pure alexia: attempted rehabilitation and its implications for interpretation of the deficit. (7953616)
1994
33
Spatial alexia. (7960468)
1994
34
Single-character processing in a case of pure alexia. (8502378)
1993
35
The evolution of pure alexia: a longitudinal study of recovery. (2285860)
1990
36
Evidence for preserved reading in 'pure alexia'. (2706436)
1989
37
Alexia without agraphia and associated disorders: importance of recognition in the rehabilitation setting. (3566519)
1987
38
Alexia without agraphia in a left-handed patient with a right occipital lesion. (3675259)
1987
39
Dynamic spelling alexia. (3701357)
1986
40
Left hemisphere pathways in reading: inferences from pure alexia without hemianopia. (4010962)
1985
41
Alexia for ideograms: implications for kanji alexia. (6518794)
1984
42
Residual reading capability in a patient with alexia without agraphia. (6518359)
1984
43
Alexia and agraphia in Wernicke's aphasia. (6101190)
1983
44
Right thalamic injury, impaired visuospatial perception, and alexia. (7199632)
1982
45
Phonological processing in reading: data from alexia. (533851)
1979
46
Ideogram reading in alexia. (1148817)
1975
47
Bee but not be: oral reading of single words in aphasia and alexia. (1153101)
1975
48
Kanji versus Kana processing in alexia with transient agraphia: a case report. (4455448)
1974
49
A visual-speech disconnexion syndrome. Report of a case with optic aphasia, agnosic alexia and colour agnosia. (4773861)
1973
50
Anatomical findings in a case of alexia without agraphia. (5413574)
1970

Genetic Variations for Alexia

About this section

Expression for genes affiliated with Alexia

About this section
Sources:
1BioGPS, 15Gene Expression Omnibus DataSets
See all sources
Expression patterns in normal tissues for genes affiliated with Alexia

Search GEO for disease gene expression data for Alexia.

Pathways for genes affiliated with Alexia

About this section
Sources:
51QIAGEN, 37NCBI BioSystems Database, 53Reactome, 29KEGG, 12EMD Millipore, 4Cell Signaling Technology
See all sources

Pathways related to Alexia according to GeneCards/GeneDecks:

(show top 50)    (show all 88)
idSuper pathways (with members indented)ScoreTop Affiliating Genes
1
Hide members
9.6LYN, PLCG1
29.2BBC3, TP73, ABL1
39.2FYN, LAT, LYN
49.1BBC3, TP73, FAS, CTSD
59.1LAT, LYN, AKT1, PLCG1
6
Apoptosis and survival Caspase cascade
Hide members
9.0FAS, PARP1, AKT1, IGF1
79.0CTSD, FAS, BBC3, PARP1
89.0PLCG1, PARP1, LAT, LYN
9
Hide members
8.9AKT1, ABL1, BBC3, TP73
108.9LYN, AKT1, FYN, LAT
11
Immune response NFAT in immune response
Hide members
8.8LAT, AKT1, PLCG1, MS4A2, LYN
128.8AKT1, IGF2, IGF1, PLCG1
13
Hide members
8.8AKT1, IGF2, PLCG1, IGF1
14
Hide members
8.8LAT, FYN, PLCG1
158.8LYN, PLCG1, FYN
168.8FYN, LYN, PLCG1
178.8LYN, FYN, PLCG1
188.8PLCG1, FYN, LYN
198.8FYN, PLCG1, LYN
208.7AKT1, PLCG1, FYN
218.7PLCG1, FYN, AKT1
22
Hide members
8.6BBC3, FAS, IGF2, IGF1, AKT1
23
Hide members
8.5LYN, MS4A2, FYN, PLCG1
248.5AKT1, FYN, TP73, ABL1
25
Hide members
8.5LAT, AKT1, PLCG1, FYN
268.5PLCG1, AKT1, LAT, FYN
27
Hide members
8.5AKT1, LAT, FYN, PLCG1
288.5LYN, FYN, PLCG1, AKT1
298.5FAS, AKT1, IGF1, PLCG1, IGF2
30
Development Prolactin receptor signaling
Hide members
8.5FYN, PLCG1, AKT1, CTSD
31
Hide members
8.5TP73, IGF1, ABL1, BBC3, FAS
328.4AKT1, ABL1, FAS, IGF1, BBC3
33
Hide members
8.4ABL1, PLCG1, AKT1, TP73, FAS
34
Hide members
8.4AKT1, IGF1, IGF2, FYN, LYN
35
Hide members
8.3LAT, MS4A2, FYN, LYN, PLCG1
36
Hide members
8.3LYN, FYN, MS4A2, LAT, PLCG1
378.3ABL1, FAS, IGF1, AKT1, PLCG1
38
Hide members
8.3BBC3, FYN, AKT1, FAS, TP73
39
Hide members
8.3LAT, FYN, PLCG1, AKT1, LYN
40
Hide members
8.0LYN, PLCG1, ABL1, LAT, FYN
41
Hide members
8.0LAT, AKT1, PLCG1, FYN, LYN, MS4A2
428.0PLCG1, AKT1, FYN, ABL1, LYN
43
Hide members
8.0LYN, FYN, PLCG1, ABL1, AKT1
44
Hide members
7.9FAS, AKT1, PLCG1, FYN, LAT, LYN
45
Hide members
7.7AKT1, FAS, LYN, LAT, MS4A2, FYN
46
Hide members
7.5LAT, PLCG1, IGF2, AKT1, FYN, LYN
47
Hide members
7.5PLCG1, IGF1, AKT1, FYN, LAT, LYN
48
Hide members
7.5IGF1, IGF2, AKT1, ABL1, PLCG1, FYN
49
Hide members
6.8FYN, BBC3, AKT1, IGF2, IGF1, LAT
50
Hide members
6.8IGF2, AKT1, BBC3, ABL1, IGF1, PLCG1

Compounds for genes affiliated with Alexia

About this section
Sources:
44Novoseek, 59Tocris Bioscience, 24HMDB, 11DrugBank, 49PharmGKB, 28IUPHAR, 2BitterDB
See all sources

Compounds related to Alexia according to GeneCards/GeneDecks:

(show top 50)    (show all 106)
idCompoundScoreTop Affiliating Genes
1cycloheximide4410.5PARP1
2ag 1024449.8IGF1, IGF2, AKT1
3tpck449.7PARP1, FAS, AKT1
4noxa449.6TP73, FAS, BBC3
5c2ceramide449.6FAS, CTSD, PARP1, AKT1
6eb 108944 5910.5IGF1, PARP1, IGF2
7estrone sulfate44 2410.5CTSD, IGF1, IGF2
8adriamycin449.3AKT1, TP73, FAS, CTSD, IGF1
9bosutinib59 1110.3ABL1, LYN, FYN
104-hydroxytamoxifen449.2IGF1, PARP1, AKT1, CTSD, IGF2
11paclitaxel44 49 1111.2PARP1, FAS, AKT1, CTSD, IGF2
12camptothecin44 59 1111.2TP73, ABL1, FAS, PARP1
13tamoxifen44 49 28 1112.2IGF1, AKT1, IGF2, CTSD, FAS
14dasatinib44 49 1111.2LYN, ABL1, FYN
15ag 1478449.1PLCG1, IGF1, AKT1, FAS
16nonidet p40449.1FYN, LYN, PLCG1
17imatinib44 49 1111.1ABL1, LYN, TP73, PARP1, IGF2
18doxorubicin44 49 1111.1PARP1, AKT1, CTSD, TP73, FAS
19ceramide449.0FAS, CTSD, AKT1, ABL1, PARP1
20phosphatidylinositol-3,4,5-trisphosphate44 2410.0AKT1, PLSCR1, PLCG1, LYN
21paraffin448.9IGF2, AKT1, TP73, CTSD, FAS
22rottlerin448.8PLSCR1, PARP1, ABL1, AKT1, FAS
23actinomycin d448.8TP73, IGF1, IGF2, AKT1, FAS, PARP1
24palmitate448.8AKT1, FYN, PLCG1, PDP1
25wortmannin448.8IGF1, FAS, PLCG1, AKT1, LYN
26dexamethasone44 49 28 1111.6AKT1, PARP1, PLCG1, IGF2, FAS
27rapamycin448.5FYN, IGF1, IGF2, FAS, AKT1
28agar448.5CTSD, FAS, AKT1, IGF2, ABL1, PLCG1
29etoposide44 49 59 1111.4AKT1, PARP1, IGF1, IGF2, CTSD, FAS
30serine448.4LYN, FYN, PLCG1, ABL1, PDP1
31glucose448.4AKT1, IGF2, CTSD, PDP1, IGF1, FYN
32glutamine448.4IGF1, PDP1, FAS, CTSD, AKT1, PLCG1
33proline448.4FYN, PDP1, LYN, TP73, ABL1
34ly294002448.3PLCG1, LYN, PARP1, IGF1, IGF2, AKT1
35phosphotyrosine448.3IGF2, ABL1, PLCG1, LYN, FYN
36cisplatin44 49 59 1111.2CTSD, IGF2, FAS, PARP1, TP73, LYN
37phosphatidylserine44 28 1110.2FAS, PARP1, PLCG1, PLSCR1, ABL1, AKT1
38herbimycin a44 599.0LYN, FYN, PLCG1, ABL1, AKT1, FAS
39inositol 1,4,5 trisphosphate448.0PLSCR1, PLCG1, FYN, LYN
40phosphoinositide448.0ABL1, FYN, LYN, PLCG1, AKT1
41adenylate448.0PLCG1, ABL1, FYN, CTSD, IGF2, AKT1
42oxygen44 248.6FAS, CTSD, ABL1, FYN, BBC3, PARP1
43genistein44 28 59 2 11 2412.5FAS, CTSD, AKT1, IGF1, PLCG1, LYN
44cysteine447.3AKT1, FAS, FYN, PLCG1, ABL1, CTSD
45lipid447.3AKT1, ABL1, PLSCR1, PLCG1, FYN, TP73
46vegf447.2FAS, CTSD, AKT1, IGF2, IGF1, PLCG1
47h2o2447.1IGF2, FAS, LYN, PLCG1, ABL1, CTSD
48phosphatidylinositol446.8CTSD, FYN, AKT1, FAS, IGF2, IGF1
49tyrosine446.6TP73, PDP1, FAS, LYN, LAT, FYN
50retinoic acid44 246.9LYN, FAS, CTSD, AKT1, IGF2, IGF1

GO Terms for genes affiliated with Alexia

About this section
Sources:
16Gene Ontology
See all sources

Cellular components related to Alexia according to GeneCards/GeneDecks:

idNameGO IDScoreTop Affiliating Genes
1membrane raftGO:0451218.8LYN, LAT, MS4A2, PLSCR1, FAS
2plasma membraneGO:0058866.4AKT1, IGF2, IGF1, PLSCR1, PLCG1, FYN
3cytosolGO:0058296.0BBC3, FAS, AKT1, ABL1, PLSCR1, PLCG1

Biological processes related to Alexia according to GeneCards/GeneDecks:

(show all 25)
idNameGO IDScoreTop Affiliating Genes
1regulation of release of sequestered calcium ion into cytosolGO:05127910.2LYN, MS4A2
2cytokine secretionGO:05066310.2LYN, MS4A2
3activation-induced cell death of T cellsGO:00692410.1FAS, AKT1
4regulation of mast cell activationGO:03300310.0LYN, PLSCR1
5negative regulation of release of cytochrome c from mitochondriaGO:0902019.9IGF1, AKT1
6positive regulation of protein homooligomerizationGO:0324649.9FAS, BBC3
7positive regulation of glycogen biosynthetic processGO:0457259.8IGF1, IGF2, AKT1
8insulin-like growth factor receptor signaling pathwayGO:0480099.8AKT1, IGF1
9positive regulation of activated T cell proliferationGO:0421049.7IGF1, IGF2
10intrinsic apoptotic signaling pathway in response to DNA damageGO:0086309.7LYN, TP73, ABL1
11platelet degranulationGO:0025769.7IGF2, IGF1, LYN
12cellular response to epidermal growth factor stimulusGO:0713649.6AKT1, PLCG1
13positive regulation of peptidyl-tyrosine phosphorylationGO:0507319.5ABL1, IGF1, IGF2
14T cell costimulationGO:0312959.4AKT1, FYN, LYN
15response to DNA damage stimulusGO:0069749.3BBC3, ABL1, TP73, LYN
16positive regulation of apoptotic processGO:0430659.3TP73, ABL1, AKT1, FAS
17positive regulation of blood vessel endothelial cell migrationGO:0435369.3PLCG1, AKT1
18peptidyl-tyrosine phosphorylationGO:0181089.2LYN, FYN, ABL1
19T cell receptor signaling pathwayGO:0508529.0PLCG1, FYN, LAT
20leukocyte migrationGO:0509008.7LYN, FYN, PLCG1
21Fc-gamma receptor signaling pathway involved in phagocytosisGO:0380968.6ABL1, PLCG1, FYN, LYN
22Fc-epsilon receptor signaling pathwayGO:0380958.4AKT1, PLCG1, FYN, MS4A2, LAT, LYN
23platelet activationGO:0301688.0LYN, AKT1, IGF2, IGF1, PLSCR1, FYN
24innate immune responseGO:0450877.9AKT1, ABL1, PLCG1, FYN, MS4A2, LAT
25blood coagulationGO:0075967.4AKT1, IGF2, IGF1, ABL1, PLCG1, FYN

Molecular functions related to Alexia according to GeneCards/GeneDecks:

(show all 7)
idNameGO IDScoreTop Affiliating Genes
1insulin-like growth factor receptor bindingGO:0051599.4IGF1, IGF2
2CD4 receptor bindingGO:0426099.2FYN, PLSCR1
3SH3 domain bindingGO:0171249.2LYN, PLSCR1, ABL1
4non-membrane spanning protein tyrosine kinase activityGO:0047159.0ABL1, FYN, LYN
5protein tyrosine kinase activityGO:0047138.8ABL1, FYN, LYN
6identical protein bindingGO:0428028.4TP73, PARP1, FYN, AKT1, FAS
7protein bindingGO:0055154.9LYN, BBC3, FAS, CTSD, AKT1, IGF2

Products for genes affiliated with Alexia

About this section
  • Antibodies
  • Proteins
  • Lysates
  • Antibodies

Sources for Alexia

About this section
3CDC
13ExPASy
14FMA
22GTR
23HGMD
24HMDB
25ICD10
26ICD10 via Orphanet
27ICD9CM
28IUPHAR
29KEGG
34MeSH
35MESH via Orphanet
36MGI
39NCIt
40NDF-RT
43NINDS
44Novoseek
46OMIM
47OMIM via Orphanet
50PubMed
51QIAGEN
57SNOMED-CT via Orphanet
60UMLS
61UMLS via Orphanet