MCID: ALX001
MIFTS: 54

Alexia malady

Summaries for Alexia

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8Disease Ontology, 32MalaCards
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Disease Ontology:8 An agnosia that is a loss of the ability to recognize text.

MalaCards: Alexia, also known as dyslexia, acquired, is related to meningioma and alzheimer's disease. An important gene associated with Alexia is LAT (linker for activation of T cells), and among its related pathways are p70S6K Signaling and TP53 network. The compounds cycloheximide and ag 1024 have been mentioned in the context of this disorder. Affiliated tissues include brain, temporal lobe and parietal lobe, and related mouse phenotypes are renal/urinary system and endocrine/exocrine gland.

Aliases & Classifications for Alexia

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Sources:
8Disease Ontology, 60UMLS, 56SNOMED-CT, 34MeSH, 27ICD9CM
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Aliases & Descriptions:

alexia 8 60
dyslexia, acquired 60
acquired dyslexia 8
aphemesthaesia 8


External Ids:

Disease Ontology8 DOID:13417
MeSH34 D004410
ICD9CM27 315.01

Related Diseases for Alexia

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17GeneCards, 18GeneDecks
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Diseases related to Alexia via text searches within MalaCards or GeneCards/GeneDecks gene sharing:

(show top 50)    (show all 123)
idRelated DiseaseScoreTop Affiliating Genes
1meningioma29.8CTSD, IGF2, PLCG1, TP73
2alzheimer's disease29.8PDP1, CTSD, AKT1, ABL1, PLCG1, FYN
3aphasia10.5
4agnosia10.4
5visual agnosia10.4
6dysgraphia10.3
7prosopagnosia10.3
8dyslexia10.2
9dementia10.2
10multiple sclerosis10.2
11cerebritis10.1
12status epilepticus10.0
13form agnosia10.0
14simultanagnosia10.0
15associative agnosia10.0
16acute disseminated encephalomyelitis10.0
17encephalitis10.0
18encephalomyelitis10.0
19migraine10.0
20neuroblastoma10.0AKT1
21sarcoma10.0IGF2
22rhabdoid tumor10.0IGF2
23hepatoblastoma10.0IGF2
24cystic fibrosis10.0PDP1
25vascular disease10.0AKT1
26hepatitis10.0PARP1
27cervical squamous cell carcinoma10.0TP73
28fanconi's anemia10.0PARP1
29fetal macrosomia10.0IGF2
30pertussis10.0PARP1
31hyperprolactinemia10.0IGF1
32hypertension10.0IGF1
33cervical adenocarcinoma10.0PARP1
34osteoarthritis10.0IGF1
35endometrial carcinoma10.0CTSD, AKT1
36laryngeal squamous cell carcinoma10.0TP73, CTSD
37werner syndrome10.0PARP1
38oral cancer10.0PARP1, TP73
39gastrointestinal stromal tumor10.0ABL1
40chondrosarcoma10.0ABL1
41multiple myeloma10.0IGF1, AKT1
42pituitary adenoma10.0TP73, IGF1
43rheumatoid arthritis10.0AKT1, FAS
44deficiency anemia10.0ABL1
45fibrosarcoma10.0FYN, AKT1
46galactosemia10.0IGF1
47insulin-like growth factor 1 resistance to10.0IGF1, IGF2
48astrocytoma10.0AKT1, PLCG1, TP73
49hepatitis c10.0FYN, FAS
50hyperandrogenism10.0IGF2, IGF1

Graphical network of the top 20 diseases related to Alexia:



Diseases related to alexia

Clinical Features for Alexia

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Drugs & Therapeutics for Alexia

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Sources:
5CenterWatch, 41NIH Clinical Center, 6ClinicalTrials
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Approved drugs:

Search CenterWatch for Alexia

Drug clinical trials:

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Search NIH Clinical Center for Alexia

Search CenterWatch for Alexia

Genetic Tests for Alexia

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Anatomical Context for Alexia

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32MalaCards
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MalaCards organs/tissues related to Alexia:

32
Brain, Temporal lobe, Parietal lobe, Eye, Cortex, Occipital lobe, Testes

Animal Models for Alexia or affiliated genes

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36MGI
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Publications for Alexia

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50PubMed
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Articles related to Alexia:

(show top 50)    (show all 285)
idTitleAuthorsYear
1
Right Brain: A reading specialist with alexia without agraphia: Teacher interrupted. (24379102)
2014
2
Bilateral Hemispheric Processing of Words and Faces: Evidence from Word Impairments in Prosopagnosia and Face Impairments in Pure Alexia. (23250954)
2013
3
Preserved visual language identification despite severe alexia. (22401988)
2012
4
The evolution of alexia in two cases of posterior cortical atrophy. (21876262)
2011
5
Pure alexia caused by separate lesions of the splenium and optic radiation. (20798952)
2011
6
Damage to the upper portion of area 19 and the deep white matter in the left inferior parietal lobe, including the superior longitudinal fasciculus, results in alexia with agraphia. (20798545)
2010
7
Chapter 37: alexia and agraphia. (19892140)
2010
8
Braille alexia: an apperceptive tactile agnosia? (17635985)
2007
9
Alexia and quadrant-amblyopia: reading disability after a minor visual field deficit. (16737722)
2006
10
Alexia without agraphia in a child with acute disseminated encephalomyelitis. (16924040)
2006
11
The neural bases of prosopagnosia and pure alexia: recent insights from functional neuroimaging. (16914978)
2006
12
One bird with two stones: Abnormal word length effects in pure alexia and semantic dementia. (21049371)
2006
13
Musical alexia with recovery: a personal account. (16959814)
2006
14
Section IV: Three As: Alexia, agraphia, agnosia. (21038211)
2004
15
Kinesthetic alexia due to left parietal lobe lesions. (12186998)
2002
16
Hanja alexia with agraphia after left posterior inferior temporal lobe infarction: a case study. (11850596)
2002
17
Evolution of a form of pure alexia without agraphia in a child sustaining occipital lobe infarction at 2 1/2 years. (9652784)
1998
18
Pure alexia: clinical-pathologic evidence for a lateralized visual language association cortex. (9401800)
1997
19
Naming difficulties in alexia with agraphia for kanji after a left posterior inferior temporal lesion. (8201334)
1994
20
Jules Dejerine and his interpretation of pure alexia. (8118672)
1993
21
Pure alexia and right hemiachromatopsia in posterior dementia. (1619420)
1992
22
Alexia without agraphia. (1630612)
1992
23
Alexia without agraphia. (1922836)
1991
24
Alexia with agraphia. (2702334)
1989
25
Resolving metabolic abnormalities in a case of pure alexia. (3258969)
1988
26
Alexia without agraphia: clinical-computed tomographic correlations. (3614625)
1987
27
Hemianopia, hemiachromatopsia and the mechanisms of alexia. (3519074)
1986
28
Preserved stenography reading in a patient with pure alexia. A model for dissociated reading processes. (3985817)
1985
29
Reversible alexia without agraphia due to migraine. (6824441)
1983
30
Isolated transient alexia. A migrainous accompaniment. (6824442)
1983
31
Word and letter reading and the mechanism of the third alexia. (7059305)
1982
32
Transtentorial herniation with posterior cerebral artery territory infarction. A new mechanism of the syndrome of alexia without agraphia. (7064196)
1982
33
Alexia and agraphia with spared spelling and letter recognition abilities. (7225784)
1981
34
Neurolinguistic analysis of the language abilities of a patient with a "double disconnection syndrome": a case of subangular alexia in the presence of mixed transcortical aphasia. (7217972)
1981
35
Alexia without agraphia: localization of the lesion by computerized tomography. (7249621)
1981
36
Music and language: musical alexia and agraphia. (7397483)
1980
37
Wernicke's and global aphasia without alexia. (435133)
1979
38
Alexia without agraphia: lateral and medial infarction of left occipital lobe. (571985)
1979
39
Phonological alexia: three dissociations. (533850)
1979
40
Reversible alexia, mitochondrial myopathy, and lactic acidemia. (571570)
1979
41
Retraining in literal alexia: substitution of a right hemisphere perceptual strategy for impaired left hemispheric processing. (617048)
1977
42
Dissociative alexia. (843264)
1977
43
Subangular alexia without agraphia or hemianopsia. (938929)
1976
44
Effect of print size on reading time in a patient with verbal alexia. (4821187)
1974
45
Alexia without agraphia with complete recovery. Functional disconnection sydrome. (4541303)
1973
46
Alexia without agraphia. A clinical and radiographical study of three unusual cases. (5061602)
1972
47
A study of patient who had alexia without agraphia. (5418179)
1970
48
Agnostic alexia in a case of vascular lesions of the brain. (5943470)
1966
49
The syndrome of alexia and amnesic aphasia; subarachnoidal haemorrhage with symptom of partial occlusion of the spinal subarachnoidal space. (18866783)
1948
50
Congenital Word- and Letter-Blindness-Alexia congenita. (19979492)
1916

Genetic Variations for Alexia

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Expression for genes affiliated with Alexia

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Sources:
1BioGPS, 15Gene Expression Omnibus DataSets
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Expression patterns in normal tissues for genes affiliated with Alexia

Search GEO for disease gene expression data for Alexia.

Pathways for genes affiliated with Alexia

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Sources:
51QIAGEN, 37NCBI BioSystems Database, 53Reactome, 29KEGG, 12EMD Millipore
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Pathways related to Alexia according to GeneCards/GeneDecks:

(show top 50)    (show all 88)
idSuper pathways (with members indented)ScoreTop Affiliating Genes
1
Hide members
9.6LYN, PLCG1
29.2BBC3, ABL1, TP73
39.2FYN, LAT, LYN
49.1BBC3, FAS, CTSD, TP73
59.1LYN, PLCG1, AKT1, LAT
6
Apoptosis and survival Caspase cascade
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9.0IGF1, FAS, AKT1, PARP1
79.0PLCG1, PARP1, LAT, LYN
8
Hide members
8.9AKT1, BBC3, ABL1, TP73
98.9FYN, LYN, LAT, AKT1
10
Immune response NFAT in immune response
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8.8MS4A2, AKT1, PLCG1, LYN, LAT
118.8IGF1, PLCG1, IGF2, AKT1
12
Hide members
8.8PLCG1, IGF2, AKT1, IGF1
13
Hide members
8.8FYN, LAT, PLCG1
148.8LYN, PLCG1, FYN
158.8PLCG1, FYN, LYN
168.8FYN, LYN, PLCG1
178.8PLCG1, LYN, FYN
188.8PLCG1, LYN, FYN
198.7PLCG1, FYN, AKT1
208.7AKT1, FYN, PLCG1
21
Development Dopamine D2 receptor transactivation of EGFR
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8.7AKT1, IGF1, FYN, PDP1
22
Hide members
8.6BBC3, IGF1, IGF2, AKT1, FAS
23
Hide members
8.5LYN, MS4A2, FYN, PLCG1
248.5FYN, ABL1, AKT1, TP73
258.5FYN, LAT, PLCG1, AKT1
26
Hide members
8.5FYN, LAT, AKT1, PLCG1
27
Hide members
8.5LAT, FYN, AKT1, PLCG1
288.5AKT1, PLCG1, LYN, FYN
298.5IGF1, FAS, AKT1, IGF2, PLCG1
30
Development Prolactin receptor signaling
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8.5FYN, PLCG1, CTSD, AKT1
31
Hide members
8.5ABL1, IGF1, FAS, BBC3, TP73
328.4BBC3, IGF1, ABL1, AKT1, FAS
33
Hide members
8.4PLCG1, AKT1, FAS, ABL1, TP73
34
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8.4LYN, FYN, IGF1, IGF2, AKT1
35
Hide members
8.3LAT, MS4A2, FYN, LYN, PLCG1
36
Hide members
8.3LYN, MS4A2, FYN, PLCG1, LAT
378.3ABL1, PLCG1, AKT1, FAS, IGF1
38
Hide members
8.3FAS, AKT1, BBC3, FYN, TP73
39
Hide members
8.3LAT, FYN, AKT1, LYN, PLCG1
40
Hide members
8.0ABL1, LAT, LYN, FYN, PLCG1
41
Hide members
8.0PLCG1, MS4A2, AKT1, FYN, LAT, LYN
42
Hide members
8.0ABL1, AKT1, PLCG1, FYN, LYN
438.0FYN, ABL1, PLCG1, LYN, AKT1
44
Hide members
7.9FYN, LAT, AKT1, FAS, PLCG1, LYN
45
Hide members
7.7LYN, PLCG1, FAS, AKT1, FYN, MS4A2
46
Hide members
7.5AKT1, IGF2, IGF1, PLCG1, FYN, LAT
47
Hide members
7.5IGF2, IGF1, PLCG1, FYN, LYN, AKT1
48
Hide members
7.5AKT1, IGF2, IGF1, ABL1, PLCG1, FYN
49
Hide members
6.8FYN, BBC3, AKT1, PLCG1, IGF1, ABL1
50
Hide members
6.8BBC3, AKT1, IGF2, IGF1, PLCG1, FYN

Compounds for genes affiliated with Alexia

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Sources:
44Novoseek, 59Tocris Bioscience, 24HMDB, 11DrugBank, 49PharmGKB, 28IUPHAR, 2BitterDB
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Compounds related to Alexia according to GeneCards/GeneDecks:

(show top 50)    (show all 106)
idCompoundScoreTop Affiliating Genes
1cycloheximide4410.5PARP1
2ag 1024449.8AKT1, IGF2, IGF1
3tpck449.7FAS, AKT1, PARP1
4noxa449.6BBC3, FAS, TP73
5c2ceramide449.6PARP1, AKT1, CTSD, FAS
6eb 108944 5910.5IGF2, IGF1, PARP1
7estrone sulfate44 2410.5IGF1, IGF2, CTSD
8adriamycin449.3FAS, CTSD, AKT1, IGF1, TP73
9bosutinib59 1110.3ABL1, FYN, LYN
104-hydroxytamoxifen449.2CTSD, AKT1, IGF2, IGF1, PARP1
11paclitaxel44 49 1111.2PARP1, IGF2, AKT1, CTSD, FAS
12camptothecin44 59 1111.2TP73, PARP1, ABL1, FAS
13tamoxifen44 49 28 1112.2FAS, CTSD, AKT1, IGF2, IGF1
14dasatinib44 49 1111.2LYN, FYN, ABL1
15ag 1478449.1FAS, AKT1, IGF1, PLCG1
16nonidet p40449.1PLCG1, FYN, LYN
17imatinib44 49 1111.1IGF2, ABL1, PARP1, TP73, LYN
18doxorubicin44 49 1111.1FAS, CTSD, AKT1, PARP1, TP73
19ceramide449.0PARP1, ABL1, AKT1, CTSD, FAS
20phosphatidylinositol-3,4,5-trisphosphate44 2410.0LYN, PLCG1, PLSCR1, AKT1
21paraffin448.9TP73, IGF2, AKT1, CTSD, FAS
22rottlerin448.8FAS, AKT1, ABL1, PLSCR1, PARP1
23actinomycin d448.8FAS, AKT1, IGF2, IGF1, PARP1, TP73
24palmitate448.8PDP1, AKT1, PLCG1, FYN
25wortmannin448.8FAS, AKT1, IGF1, PLCG1, LYN
26dexamethasone44 49 28 1111.6FAS, AKT1, IGF2, PLCG1, PARP1
27rapamycin448.5FAS, AKT1, IGF2, IGF1, FYN
28agar448.5FAS, CTSD, AKT1, IGF2, ABL1, PLCG1
29etoposide44 49 59 1111.4BBC3, FAS, CTSD, AKT1, IGF2, IGF1
30serine448.4PDP1, ABL1, PLCG1, FYN, LYN
31glucose448.4FYN, IGF1, IGF2, AKT1, CTSD, PDP1
32glutamine448.4PDP1, FAS, CTSD, AKT1, IGF2, IGF1
33proline448.4LYN, TP73, FYN, ABL1, PDP1
34ly294002448.3FAS, AKT1, IGF2, IGF1, PLCG1, PARP1
35phosphotyrosine448.3IGF2, ABL1, PLCG1, FYN, LYN
36cisplatin44 49 59 1111.2FAS, CTSD, AKT1, IGF2, ABL1, PARP1
37phosphatidylserine44 28 1110.2FAS, AKT1, ABL1, PLSCR1, PLCG1, PARP1
38herbimycin a44 599.0FAS, AKT1, ABL1, PLCG1, FYN, LYN
39inositol 1,4,5 trisphosphate448.0PLSCR1, PLCG1, FYN, LYN
40phosphoinositide448.0AKT1, ABL1, PLCG1, FYN, LYN
41adenylate448.0CTSD, AKT1, IGF2, ABL1, PLCG1, FYN
42oxygen44 248.6BBC3, PDP1, FAS, CTSD, ABL1, FYN
43genistein44 28 59 2 11 2412.5FAS, CTSD, AKT1, IGF1, PLCG1, FYN
44cysteine447.3FAS, CTSD, AKT1, IGF2, ABL1, PLCG1
45lipid447.3AKT1, ABL1, PLSCR1, PLCG1, FYN, LAT
46vegf447.2FAS, CTSD, AKT1, IGF2, IGF1, PLCG1
47h2o2447.1FAS, CTSD, AKT1, IGF2, ABL1, PLCG1
48phosphatidylinositol446.8FAS, CTSD, AKT1, IGF2, IGF1, ABL1
49tyrosine446.6PDP1, FAS, AKT1, IGF2, IGF1, ABL1
50retinoic acid44 246.9LYN, FAS, CTSD, AKT1, IGF2, IGF1

GO Terms for genes affiliated with Alexia

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16Gene Ontology
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Cellular components related to Alexia according to GeneCards/GeneDecks:

idNameGO IDScoreTop Affiliating Genes
1membrane raftGO:0451218.8LYN, LAT, MS4A2, PLSCR1, FAS
2plasma membraneGO:0058866.4AKT1, IGF2, IGF1, PLSCR1, PLCG1, FYN
3cytosolGO:0058296.0BBC3, FAS, AKT1, ABL1, PLSCR1, PLCG1

Biological processes related to Alexia according to GeneCards/GeneDecks:

(show all 25)
idNameGO IDScoreTop Affiliating Genes
1regulation of release of sequestered calcium ion into cytosolGO:05127910.2LYN, MS4A2
2cytokine secretionGO:05066310.2LYN, MS4A2
3activation-induced cell death of T cellsGO:00692410.1FAS, AKT1
4regulation of mast cell activationGO:03300310.0LYN, PLSCR1
5negative regulation of release of cytochrome c from mitochondriaGO:0902019.9IGF1, AKT1
6positive regulation of protein homooligomerizationGO:0324649.9FAS, BBC3
7positive regulation of glycogen biosynthetic processGO:0457259.8IGF1, IGF2, AKT1
8insulin-like growth factor receptor signaling pathwayGO:0480099.8AKT1, IGF1
9positive regulation of activated T cell proliferationGO:0421049.7IGF1, IGF2
10intrinsic apoptotic signaling pathway in response to DNA damageGO:0086309.7LYN, TP73, ABL1
11platelet degranulationGO:0025769.7IGF2, IGF1, LYN
12cellular response to epidermal growth factor stimulusGO:0713649.6AKT1, PLCG1
13positive regulation of peptidyl-tyrosine phosphorylationGO:0507319.5ABL1, IGF1, IGF2
14T cell costimulationGO:0312959.4AKT1, FYN, LYN
15response to DNA damage stimulusGO:0069749.3BBC3, ABL1, TP73, LYN
16positive regulation of apoptotic processGO:0430659.3TP73, ABL1, AKT1, FAS
17positive regulation of blood vessel endothelial cell migrationGO:0435369.3PLCG1, AKT1
18peptidyl-tyrosine phosphorylationGO:0181089.2LYN, FYN, ABL1
19T cell receptor signaling pathwayGO:0508529.0PLCG1, FYN, LAT
20leukocyte migrationGO:0509008.7LYN, FYN, PLCG1
21Fc-gamma receptor signaling pathway involved in phagocytosisGO:0380968.6ABL1, PLCG1, FYN, LYN
22Fc-epsilon receptor signaling pathwayGO:0380958.4AKT1, PLCG1, FYN, MS4A2, LAT, LYN
23platelet activationGO:0301688.0LYN, AKT1, IGF2, IGF1, PLSCR1, FYN
24innate immune responseGO:0450877.9AKT1, ABL1, PLCG1, FYN, MS4A2, LAT
25blood coagulationGO:0075967.4AKT1, IGF2, IGF1, ABL1, PLCG1, FYN

Molecular functions related to Alexia according to GeneCards/GeneDecks:

(show all 7)
idNameGO IDScoreTop Affiliating Genes
1insulin-like growth factor receptor bindingGO:0051599.4IGF1, IGF2
2CD4 receptor bindingGO:0426099.2FYN, PLSCR1
3SH3 domain bindingGO:0171249.2LYN, PLSCR1, ABL1
4non-membrane spanning protein tyrosine kinase activityGO:0047159.0ABL1, FYN, LYN
5protein tyrosine kinase activityGO:0047138.8ABL1, FYN, LYN
6identical protein bindingGO:0428028.4TP73, PARP1, FYN, AKT1, FAS
7protein bindingGO:0055154.9LYN, BBC3, FAS, CTSD, AKT1, IGF2

Products for genes affiliated with Alexia

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  • Antibodies
  • Proteins
  • Lysates
  • Antibodies

Sources for Alexia

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3CDC
13ExPASy
14FMA
22GTR
23HGMD
24HMDB
25ICD10
26ICD10 via Orphanet
27ICD9CM
28IUPHAR
29KEGG
34MeSH
35MESH via Orphanet
36MGI
39NCIt
40NDF-RT
43NINDS
44Novoseek
46OMIM
47OMIM via Orphanet
50PubMed
51QIAGEN
57SNOMED-CT via Orphanet
60UMLS
61UMLS via Orphanet