MCID: ALX001
MIFTS: 51

Alexia malady

Summaries for Alexia

Sources:
8Disease Ontology, 33MalaCards
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Disease Ontology:8 An agnosia that is a loss of the ability to recognize text.

MalaCards: Alexia, also known as dyslexia, acquired, is related to aphasia and agnosia. An important gene associated with Alexia is LAT (linker for activation of T cells), and among its related pathways are p70S6K Signaling and TP53 network. The compounds cycloheximide and ag 1024 have been mentioned in the context of this disorder. Affiliated tissues include brain, cortex and parietal lobe, and related mouse phenotypes are renal/urinary system and endocrine/exocrine gland.

Aliases & Classifications for Alexia

Sources:
8Disease Ontology, 61UMLS, 57SNOMED-CT, 35MeSH, 27ICD9CM
See all sources

Aliases & Descriptions:

alexia 8 61
dyslexia, acquired 61
acquired dyslexia 8
aphemesthaesia 8


External Ids:

Disease Ontology8 DOID:13417
MeSH35 D004410
ICD9CM27 315.01

Related Diseases for Alexia

Sources:
17GeneCards, 18GeneDecks
See all sources

Diseases related to Alexia via text searches within MalaCards or GeneCards/GeneDecks gene sharing:

(show top 50)    (show all 117)
idRelated DiseaseScoreTop Affiliating Genes
1aphasia10.5
2agnosia10.5
3visual agnosia10.4
4dysgraphia10.3
5prosopagnosia10.3
6dyslexia10.3
7blindness10.3
8posterior cortical atrophy10.3
9n syndrome10.2
10status epilepticus10.1
11form agnosia10.1
12simultanagnosia10.1
13associative agnosia10.1
14acute disseminated encephalomyelitis10.1
15semantic dementia10.1
16neuroblastoma10.0AKT1
17sarcoma10.0IGF2
18rhabdoid tumor10.0IGF2
19hepatoblastoma10.0IGF2
20vascular disease10.0AKT1
21cystic fibrosis10.0PDP1
22skin cancer10.0AKT1
23hepatitis10.0PARP1
24cervical squamous cell carcinoma10.0TP73
25fanconi's anemia10.0PARP1
26fetal macrosomia10.0IGF2
27pertussis10.0PARP1
28hyperprolactinemia10.0IGF1
29hypertension10.0IGF1
30cervical adenocarcinoma10.0PARP1
31osteoarthritis10.0IGF1
32endometrial carcinoma10.0CTSD, AKT1
33laryngeal squamous cell carcinoma10.0TP73, CTSD
34werner syndrome10.0PARP1
35oral cancer10.0PARP1, TP73
36gastrointestinal stromal tumor10.0ABL1
37chondrosarcoma10.0ABL1
38multiple myeloma10.0IGF1, AKT1
39pituitary adenoma10.0TP73, IGF1
40rheumatoid arthritis10.0AKT1, FAS
41deficiency anemia10.0ABL1
42fibrosarcoma10.0FYN, AKT1
43insulin-like growth factor 1 resistance to10.0IGF1, IGF2
44astrocytoma10.0AKT1, PLCG1, TP73
45hepatitis c10.0FYN, FAS
46hyperandrogenism10.0IGF2, IGF1
47galactosemia10.0IGF1
48polycystic ovary syndrome10.0IGF1, IGF2
49cervical cancer10.0TP73, PARP1, CTSD
50laron syndrome10.0IGF2, IGF1

Graphical network of the top 20 diseases related to Alexia:



Diseases related to alexia

Clinical Features for Alexia

Drugs & Therapeutics for Alexia

Sources:
5CenterWatch, 42NIH Clinical Center, 6ClinicalTrials
See all sources

Approved drugs:

Search CenterWatch for Alexia

Drug clinical trials:

Search ClinicalTrials for Alexia

Search NIH Clinical Center for Alexia

Search CenterWatch for Alexia

Genetic Tests for Alexia

Anatomical Context for Alexia

Sources:
33MalaCards
See all sources

MalaCards organs/tissues related to Alexia:

33
Brain, Cortex, Parietal lobe, Temporal lobe, Occipital lobe

Animal Models for Alexia or affiliated genes

Sources:
37MGI, 28inGenious Targeting Laboratory
See all sources

Publications for Alexia

Sources:
51PubMed
See all sources

Articles related to Alexia:

(show top 50)    (show all 287)
idTitleAuthorsYear
1
Reading therapy strengthens top-down connectivity in patients with pure alexia. (23884814)
2013
2
"Seeing but not identifying": pure alexia coincident with prosopagnosia in occipital arteriovenous malformation. (21243372)
2011
3
Neurophysiological correlates of post-hypnotic alexia: a controlled study with Stroop test. (20187340)
2010
4
Hanja (Ideogram) alexia and agraphia in patients with semantic dementia. (19967597)
2010
5
Implicit reading in Chinese pure alexia. (20669371)
2010
6
Visual processing in pure alexia: a case study. (19446802)
2010
7
Repetition priming in oral text reading: a therapeutic strategy for phonologic text alexia. (20664804)
2009
8
A patient with phonologic alexia can learn to read "much" from "mud pies". (18513760)
2008
9
Pure alexia as a disconnection syndrome: new diffusion imaging evidence for an old concept. (18586235)
2008
10
Nonconvulsive status epilepticus manifesting as pure alexia (alexia without agraphia). (17418645)
2007
11
Patterns of peripheral paralexia: pure alexia and the forgotten visual dyslexia? (17131595)
2006
12
Pure alexia: past and present. (16529144)
2006
13
Magnetic resonance tractography in a patient with alexia without agraphia. (16340212)
2005
14
Acquired surface alexia in Spanish: a case report. (16410626)
2005
15
Alexia without agraphia following cerebral venous thrombosis associated with protein C and protein S deficiency. (16311147)
2005
16
Aphasia, alexia, and oral reading. (14872397)
2004
17
Alexia without agraphia following biopsy of a left thalamic tumor. (14984910)
2004
18
Musical alexia for rhythm notation: a discrepancy between pitch and rhythm. (12925929)
2003
19
Mechanisms of pure alexia: spatially based impairment, letter identification deficit, or both? (12925940)
2003
20
Alexia without agraphia: a century later. (11351780)
2001
21
Alexia caused by a fusiform or posterior inferior temporal lesion. (11018248)
2000
22
Could pure alexia be due to a disconnection syndrome? (9521304)
1998
23
Visual complexity in letter-by-letter reading: "pure" alexia is not pure. (9842758)
1998
24
Prosopagnosia and alexia without object agnosia. (9669105)
1998
25
Music alexia in a patient with mild pure alexia: disturbed visual perception of nonverbal meaningful figures. (9088731)
1997
26
Recovery from deep alexia to phonological alexia: points on a continuum. (8741978)
1996
27
Alexia without either agraphia or hemianopia in temporal lobe lesion due to herpes simplex encephalitis. (7550926)
1995
28
Knowledge, implicit knowledge and metaknowledge in visual agnosia and pure alexia. (7600095)
1995
29
Transcortical alexia with agraphia following a right temporo-occipital hematoma in a right-handed patient. (7845566)
1994
30
Alexia in dementia of the Alzheimer's type. (8116346)
1993
31
The Gogi (word-meaning) syndrome with impaired kanji processing: alexia with agraphia. (8353730)
1993
32
Reading in pure alexia. The effect of strategy. (8453458)
1993
33
Alexia without agraphia: potential for model assisted therapy. (1301889)
1992
34
Alexia without agraphia associated with spleniogeniculate infarction. (2011260)
1991
35
Pure alexia in Japanese and agraphia without alexia in kanji. The ability dissociation between reading and writing in kanji vs kana. (3178534)
1988
36
Phonological alexia with optic and tactile anomia: a neuropsychological and anatomical study. (3580836)
1987
37
Visual agnosia without alexia. (6539870)
1984
38
Alexia without agraphia: a reversible syndrome. (7425584)
1980
39
Alexia without agraphia in a musician after transcallosal removal of a left intraventricular meningioma. (440550)
1979
40
Recovery from alexia without agraphia: report of an autopsy. (477344)
1979
41
Rehabilitation of alexia: a case study. (446038)
1979
42
Alexia and left homonymous hemianopia in a non-right-hander. (677820)
1978
43
Functional disconnection in pure alexia and color naming deficit demonstrated by facilitation methods. (1268693)
1976
44
Alexia with left homonymous hemianopia without agraphia. A case report with autopsy findings. (1238959)
1975
45
Subdural hematoma complicated by homonymous hemianopia and alexia. (4818637)
1974
46
Alexia without agraphia. (5957891)
1966
47
Color-naming defects in association with alexia. (5828495)
1964
48
Agnostic alexia without agraphia following trauma; report of a case. (18119669)
1949
49
The syndrome of visual alexia with colour agnosia. (18866782)
1948
50
DEVELOPMENTAL APHASIA: Also known as Congenital Word-blindness and sometimes referred to as Alexia or Dyslexia. (18170488)
1948

Genetic Variations for Alexia

Expression for genes affiliated with Alexia

Sources:
1BioGPS, 15Gene Expression Omnibus DataSets
See all sources
Expression patterns in normal tissues for genes affiliated with Alexia

Search GEO for disease gene expression data for Alexia.

Pathways for genes affiliated with Alexia

Sources:
52QIAGEN, 38NCBI BioSystems Database, 54Reactome, 30KEGG, 12EMD Millipore
See all sources

Pathways related to Alexia according to GeneCards/GeneDecks:

(show top 50)    (show all 88)
idSuper pathways (with members indented)ScoreTop Affiliating Genes
1
Hide members
9.6LYN, PLCG1
29.2BBC3, ABL1, TP73
39.2LYN, LAT, FYN
49.1BBC3, FAS, CTSD, TP73
59.1AKT1, PLCG1, LAT, LYN
6
Apoptosis and survival Caspase cascade
Hide members
9.0FAS, AKT1, IGF1, PARP1
79.0PLCG1, PARP1, LAT, LYN
8
Hide members
8.9TP73, ABL1, AKT1, BBC3
98.9LYN, LAT, FYN, AKT1
10
Immune response NFAT in immune response
Hide members
8.8AKT1, PLCG1, MS4A2, LAT, LYN
118.8AKT1, IGF2, IGF1, PLCG1
12
Hide members
8.8PLCG1, IGF1, IGF2, AKT1
13
Hide members
8.8LAT, FYN, PLCG1
148.8PLCG1, FYN, LYN
158.8LYN, FYN, PLCG1
168.8PLCG1, FYN, LYN
178.8LYN, FYN, PLCG1
188.8LYN, FYN, PLCG1
198.7AKT1, PLCG1, FYN
208.7AKT1, PLCG1, FYN
21
Development Dopamine D2 receptor transactivation of EGFR
Hide members
8.7FYN, IGF1, AKT1, PDP1
22
Hide members
8.6BBC3, FAS, AKT1, IGF2, IGF1
23
Hide members
8.5PLCG1, FYN, MS4A2, LYN
248.5TP73, FYN, ABL1, AKT1
258.5AKT1, PLCG1, FYN, LAT
26
Hide members
8.5LAT, FYN, PLCG1, AKT1
27
Hide members
8.5LAT, FYN, PLCG1, AKT1
288.5AKT1, PLCG1, FYN, LYN
298.5FAS, AKT1, IGF2, IGF1, PLCG1
30
Development Prolactin receptor signaling
Hide members
8.5CTSD, AKT1, PLCG1, FYN
31
Hide members
8.5BBC3, FAS, IGF1, ABL1, TP73
328.4BBC3, FAS, AKT1, IGF1, ABL1
33
Hide members
8.4FAS, AKT1, ABL1, PLCG1, TP73
34
Hide members
8.4LYN, FYN, IGF1, IGF2, AKT1
35
Hide members
8.3PLCG1, FYN, MS4A2, LAT, LYN
36
Hide members
8.3PLCG1, FYN, MS4A2, LAT, LYN
378.3FAS, AKT1, IGF1, ABL1, PLCG1
38
Hide members
8.3BBC3, FAS, AKT1, FYN, TP73
39
Hide members
8.3AKT1, PLCG1, FYN, LAT, LYN
40
Hide members
8.0ABL1, PLCG1, FYN, LAT, LYN
41
Hide members
8.0AKT1, PLCG1, FYN, MS4A2, LAT, LYN
42
Hide members
8.0AKT1, ABL1, PLCG1, FYN, LYN
438.0LYN, FYN, PLCG1, ABL1, AKT1
44
Hide members
7.9FAS, AKT1, PLCG1, FYN, LAT, LYN
45
Hide members
7.7FAS, AKT1, PLCG1, FYN, MS4A2, LAT
46
Hide members
7.5AKT1, IGF2, IGF1, PLCG1, FYN, LAT
47
Hide members
7.5AKT1, IGF2, IGF1, PLCG1, FYN, LAT
48
Hide members
7.5AKT1, IGF2, IGF1, ABL1, PLCG1, FYN
49
Hide members
6.8BBC3, AKT1, IGF2, IGF1, ABL1, PLCG1
50
Hide members
6.8BBC3, AKT1, IGF2, IGF1, ABL1, PLCG1

Compounds for genes affiliated with Alexia

Sources:
45Novoseek, 60Tocris Bioscience, 24HMDB, 11DrugBank, 50PharmGKB, 29IUPHAR, 2BitterDB
See all sources

Compounds related to Alexia according to GeneCards/GeneDecks:

(show top 50)    (show all 106)
idCompoundScoreTop Affiliating Genes
1cycloheximide4510.5PARP1
2ag 1024459.8IGF1, IGF2, AKT1
3tpck459.7PARP1, FAS, AKT1
4noxa459.6TP73, FAS, BBC3
5c2ceramide459.6FAS, CTSD, PARP1, AKT1
6eb 108945 6010.5IGF1, PARP1, IGF2
7estrone sulfate45 2410.5CTSD, IGF1, IGF2
8adriamycin459.3AKT1, TP73, FAS, CTSD, IGF1
9bosutinib60 1110.3ABL1, LYN, FYN
104-hydroxytamoxifen459.2IGF1, PARP1, AKT1, CTSD, IGF2
11paclitaxel45 50 1111.2PARP1, FAS, AKT1, CTSD, IGF2
12camptothecin45 60 1111.2TP73, ABL1, FAS, PARP1
13tamoxifen45 50 29 1112.2IGF1, AKT1, IGF2, CTSD, FAS
14dasatinib45 50 1111.2LYN, ABL1, FYN
15ag 1478459.1PLCG1, IGF1, AKT1, FAS
16nonidet p40459.1FYN, LYN, PLCG1
17imatinib45 50 1111.1ABL1, LYN, TP73, PARP1, IGF2
18doxorubicin45 50 1111.1PARP1, AKT1, CTSD, TP73, FAS
19ceramide459.0FAS, CTSD, AKT1, ABL1, PARP1
20phosphatidylinositol-3,4,5-trisphosphate45 2410.0AKT1, PLSCR1, PLCG1, LYN
21paraffin458.9IGF2, AKT1, TP73, CTSD, FAS
22rottlerin458.8PLSCR1, PARP1, ABL1, AKT1, FAS
23actinomycin d458.8TP73, IGF1, IGF2, AKT1, FAS, PARP1
24palmitate458.8AKT1, FYN, PLCG1, PDP1
25wortmannin458.8IGF1, FAS, PLCG1, AKT1, LYN
26dexamethasone45 50 29 1111.6AKT1, PARP1, PLCG1, IGF2, FAS
27rapamycin458.5FYN, IGF1, IGF2, FAS, AKT1
28agar458.5CTSD, FAS, AKT1, IGF2, ABL1, PLCG1
29etoposide45 50 60 1111.4AKT1, PARP1, IGF1, IGF2, CTSD, FAS
30serine458.4LYN, FYN, PLCG1, ABL1, PDP1
31glucose458.4AKT1, IGF2, CTSD, PDP1, IGF1, FYN
32glutamine458.4IGF1, PDP1, FAS, CTSD, AKT1, PLCG1
33proline458.4FYN, PDP1, LYN, TP73, ABL1
34ly294002458.3PLCG1, LYN, PARP1, IGF1, IGF2, AKT1
35phosphotyrosine458.3IGF2, ABL1, PLCG1, LYN, FYN
36cisplatin45 50 60 1111.2CTSD, IGF2, FAS, PARP1, TP73, LYN
37phosphatidylserine45 29 1110.2FAS, PARP1, PLCG1, PLSCR1, ABL1, AKT1
38herbimycin a45 609.0LYN, FYN, PLCG1, ABL1, AKT1, FAS
39inositol 1,4,5 trisphosphate458.0PLSCR1, PLCG1, FYN, LYN
40phosphoinositide458.0ABL1, FYN, LYN, PLCG1, AKT1
41adenylate458.0PLCG1, ABL1, FYN, CTSD, IGF2, AKT1
42oxygen45 248.6FAS, CTSD, ABL1, FYN, BBC3, PARP1
43genistein45 29 60 2 11 2412.5FAS, CTSD, AKT1, IGF1, PLCG1, LYN
44cysteine457.3AKT1, FAS, FYN, PLCG1, ABL1, CTSD
45lipid457.3AKT1, ABL1, PLSCR1, PLCG1, FYN, TP73
46vegf457.2FAS, CTSD, AKT1, IGF2, IGF1, PLCG1
47h2o2457.1IGF2, FAS, LYN, PLCG1, ABL1, CTSD
48phosphatidylinositol456.8CTSD, FYN, AKT1, FAS, IGF2, IGF1
49tyrosine456.6TP73, PDP1, FAS, LYN, LAT, FYN
50retinoic acid45 246.9LYN, FAS, CTSD, AKT1, IGF2, IGF1

GO Terms for genes affiliated with Alexia

Sources:
16Gene Ontology
See all sources

Cellular components related to Alexia according to GeneCards/GeneDecks:

idNameGO IDScoreTop Affiliating Genes
1membrane raftGO:0451218.8LYN, LAT, MS4A2, PLSCR1, FAS
2plasma membraneGO:0058866.4AKT1, IGF2, IGF1, PLSCR1, PLCG1, FYN
3cytosolGO:0058296.0BBC3, FAS, AKT1, ABL1, PLSCR1, PLCG1

Biological processes related to Alexia according to GeneCards/GeneDecks:

(show all 25)
idNameGO IDScoreTop Affiliating Genes
1regulation of release of sequestered calcium ion into cytosolGO:05127910.2MS4A2, LYN
2cytokine secretionGO:05066310.2MS4A2, LYN
3activation-induced cell death of T cellsGO:00692410.1FAS, AKT1
4regulation of mast cell activationGO:03300310.0PLSCR1, LYN
5negative regulation of release of cytochrome c from mitochondriaGO:0902019.9AKT1, IGF1
6positive regulation of protein homooligomerizationGO:0324649.9FAS, BBC3
7positive regulation of glycogen biosynthetic processGO:0457259.8IGF1, AKT1, IGF2
8insulin-like growth factor receptor signaling pathwayGO:0480099.8AKT1, IGF1
9positive regulation of activated T cell proliferationGO:0421049.7IGF2, IGF1
10intrinsic apoptotic signaling pathway in response to DNA damageGO:0086309.7LYN, TP73, ABL1
11platelet degranulationGO:0025769.7LYN, IGF2, IGF1
12cellular response to epidermal growth factor stimulusGO:0713649.6AKT1, PLCG1
13positive regulation of peptidyl-tyrosine phosphorylationGO:0507319.5IGF2, IGF1, ABL1
14T cell costimulationGO:0312959.4LYN, FYN, AKT1
15response to DNA damage stimulusGO:0069749.3TP73, LYN, BBC3, ABL1
16positive regulation of apoptotic processGO:0430659.3FAS, AKT1, ABL1, TP73
17positive regulation of blood vessel endothelial cell migrationGO:0435369.3AKT1, PLCG1
18peptidyl-tyrosine phosphorylationGO:0181089.2FYN, ABL1, LYN
19T cell receptor signaling pathwayGO:0508529.0LAT, FYN, PLCG1
20leukocyte migrationGO:0509008.7FYN, PLCG1, LYN
21Fc-gamma receptor signaling pathway involved in phagocytosisGO:0380968.6FYN, LYN, ABL1, PLCG1
22Fc-epsilon receptor signaling pathwayGO:0380958.4AKT1, LAT, LYN, MS4A2, FYN, PLCG1
23platelet activationGO:0301688.0PLSCR1, LYN, LAT, FYN, IGF1, IGF2
24innate immune responseGO:0450877.9ABL1, PLCG1, FYN, MS4A2, AKT1, LAT
25blood coagulationGO:0075967.4PLCG1, AKT1, IGF2, IGF1, ABL1, FYN

Molecular functions related to Alexia according to GeneCards/GeneDecks:

(show all 7)
idNameGO IDScoreTop Affiliating Genes
1insulin-like growth factor receptor bindingGO:0051599.4IGF2, IGF1
2CD4 receptor bindingGO:0426099.2PLSCR1, FYN
3SH3 domain bindingGO:0171249.2PLSCR1, ABL1, LYN
4non-membrane spanning protein tyrosine kinase activityGO:0047159.0LYN, FYN, ABL1
5protein tyrosine kinase activityGO:0047138.8ABL1, FYN, LYN
6identical protein bindingGO:0428028.4PARP1, TP73, FYN, AKT1, FAS
7protein bindingGO:0055154.9IGF1, FYN, PLCG1, PLSCR1, ABL1, IGF2

Products for genes affiliated with Alexia

  • Antibodies
  • Proteins
  • Lysates
  • Antibodies

Sources for Alexia

3CDC
13ExPASy
14FMA
22GTR
23HGMD
24HMDB
25ICD10
26ICD10 via Orphanet
27ICD9CM
29IUPHAR
30KEGG
35MeSH
36MESH via Orphanet
37MGI
40NCIt
41NDF-RT
44NINDS
45Novoseek
47OMIM
48OMIM via Orphanet
51PubMed
52QIAGEN
58SNOMED-CT via Orphanet
61UMLS
62UMLS via Orphanet