MCID: ALX002
MIFTS: 37

Alexithymia malady

Categories: Mental diseases

Aliases & Classifications for Alexithymia

Aliases & Descriptions for Alexithymia:

Name: Alexithymia 12 14

Classifications:



External Ids:

Disease Ontology 12 DOID:0060131

Summaries for Alexithymia

Disease Ontology : 12 An agnosia that is a deficiency in understanding, processing, or describing emotions.

MalaCards based summary : Alexithymia is related to personality disorder and alopecia. An important gene associated with Alexithymia is ANKK1 (Ankyrin Repeat And Kinase Domain Containing 1), and among its related pathways/superpathways are cAMP signaling pathway and Paroxetine Pathway, Pharmacokinetics. The drugs Sertraline and Serotonin have been mentioned in the context of this disorder. Affiliated tissues include brain, testes and breast, and related phenotype is Weakly decreased NFAT1-GFP nuclear translocation.

Wikipedia : 71 Alexithymia /ˌeɪlɛksəˈθaɪmiə/ is a personality construct characterized by the subclinical... more...

Related Diseases for Alexithymia

Diseases related to Alexithymia via text searches within MalaCards or GeneCards Suite gene sharing:

(show top 50) (show all 152)
id Related Disease Score Top Affiliating Genes
1 personality disorder 29.7 COMT DRD2 HTR1A SLC6A4
2 alopecia 29.5 ANKK1 DRD2 SLC6A4
3 schizophrenia 28.6 ANKK1 COMT CRP DRD2 HTR1A OXTR
4 social emotional agnosia 10.8
5 nephronophthisis 13 10.3 COMT SLC6A4
6 clostridium difficile colitis 10.2 IL4 SLC6A4
7 intrahepatic gall duct cancer 10.2 COMT SLC6A4
8 intracranial cavernous angioma 10.2 DRD2 SLC6A4
9 splenic abscess 10.2 DRD2 SLC6A4
10 ornithosis 10.2 DRD2 SLC6A4
11 rhinoscleroma 10.2 COMT DRD2
12 euthyroid sick syndrome 10.2 DRD2 SLC6A4
13 pyromania 10.2 DRD2 SLC6A4
14 c8 deficiency, type ii 10.2 COMT DRD2
15 testicular leydig cell tumor 10.2 COMT IL4
16 intracranial aneurysm 10.1 ANKK1 DRD2
17 18p deletion syndrome 10.1 ANKK1 DRD2
18 urea cycle disorder 10.1 COMT DRD2
19 interstitial emphysema 10.1 DRD2 SLC6A4
20 nephrogenic adenoma of the urethra 10.1 DRD2 SLC6A4
21 brugada syndrome 10.1 OXTR SLC6A4
22 hypertrophic elongation of cervix 10.1 CRP IL4
23 breast reconstruction 10.1 COMT DRD2
24 colorectal adenocarcinoma 10.1 COMT DRD2 SLC6A4
25 cytomegalic congenital adrenal hypoplasia 10.1 COMT DRD2 SLC6A4
26 dry eye syndrome 10.1 HTR1A SLC6A4
27 cholesteatoma 10.1 COMT DRD2 SLC6A4
28 hereditary multiple exostoses 10.1 COMT DRD2 SLC6A4
29 anodontia 10.1 HTR1A SLC6A4
30 adult brainstem astrocytoma 10.1 HTR1A SLC6A4
31 eating disorder 10.0
32 kidney pelvis papillary carcinoma 10.0 HTR1A SLC6A4
33 hypoglycemia 10.0 ANKK1 DRD2 SLC6A4
34 myiasis 10.0 CRP IL4
35 tinea pedis 10.0 HTR1A SLC6A4
36 basal cell carcinoma 3 10.0 ANKK1 COMT DRD2
37 hypoglycemic coma 10.0 HTR1A SLC6A4
38 somatoform disorder 10.0
39 patellar tendinitis 10.0 IL4 TAS2R38
40 chorea gravidarum 10.0 DRD2 HTR1A
41 renpenning syndrome 10.0 COMT HTR1A SLC6A4
42 panic disorder 10.0
43 chronic eosinophilic pneumonia 10.0 COMT HTR1A SLC6A4
44 multiple personality disorder 10.0 COMT HTR1A SLC6A4
45 primary angle-closure glaucoma 10.0 COMT HTR1A SLC6A4
46 keratosis 10.0 COMT HTR1A SLC6A4
47 allergic hypersensitivity disease 10.0 DRD2 HTR1A
48 vascular cancer 9.9 DRD2 HTR1A
49 lichen disease 9.9 COMT HTR1A SLC6A4
50 fechtner syndrome 9.9 COMT HTR1A SLC6A4

Graphical network of the top 20 diseases related to Alexithymia:



Diseases related to Alexithymia

Symptoms & Phenotypes for Alexithymia

GenomeRNAi Phenotypes related to Alexithymia according to GeneCards Suite gene sharing:

26
id Description GenomeRNAi Source Accession Score Top Affiliating Genes
1 Weakly decreased NFAT1-GFP nuclear translocation GR00359-A 8.92 ANKK1 COMT HTR1A SLC6A4

Drugs & Therapeutics for Alexithymia

Drugs for Alexithymia (from DrugBank, HMDB, Dgidb, PharmGKB, IUPHAR, NovoSeek, BitterDB):

(show all 36)
id Name Status Phase Clinical Trials Cas Number PubChem Id
1
Sertraline Approved Phase 4 79617-96-2 68617
2
Serotonin Phase 4,Phase 2 50-67-9 5202
3 Serotonin Agents Phase 4,Phase 2
4 Serotonin Uptake Inhibitors Phase 4
5 Neurotransmitter Agents Phase 4,Phase 2
6 Neurotransmitter Uptake Inhibitors Phase 4,Phase 2
7 Antidepressive Agents Phase 4
8 Psychotropic Drugs Phase 4,Phase 2
9
Oxytocin Approved, Vet_approved Phase 2 50-56-6 439302 53477758
10
3,4-Methylenedioxyamphetamine Experimental, Illicit Phase 2 4764-17-4 1614
11 Oxytocics Phase 2
12 N-Methyl-3,4-methylenedioxyamphetamine Phase 2
13 Adrenergic Agents Phase 2
14 Hallucinogens Phase 2
15
Acetylcysteine Approved, Investigational Phase 1 616-91-1 12035
16 N-monoacetylcystine Phase 1
17 Vitamins Phase 1
18 Expectorants Phase 1
19 Anti-Infective Agents Phase 1
20 Protective Agents Phase 1
21 Antidotes Phase 1
22 Respiratory System Agents Phase 1
23 Antiviral Agents Phase 1
24 Antioxidants Phase 1
25
Norepinephrine Approved 51-41-2 439260
26
Dopamine Approved 51-61-6, 62-31-7 681
27
Hydrocortisone Approved, Vet_approved 50-23-7 5754 657311
28 Analgesics
29 Serotonin and Noradrenaline Reuptake Inhibitors
30 Cortisol succinate
31 Peripheral Nervous System Agents
32 Dopamine Agents
33 Duloxetine Hydrochloride
34 Hydrocortisone 17-butyrate 21-propionate
35 Hydrocortisone acetate
36 Anti-Inflammatory Agents

Interventional clinical trials:

(show all 30)
id Name Status NCT ID Phase
1 Clinical Assessment and Psychosocial Impact of Psoriasis Completed NCT01964443 Phase 4
2 Cognitive Behavioral Therapy Versus Sertraline in the Treatment of Post-Traumatic Stress Disorder Completed NCT00391430 Phase 4
3 Pain and Stress Management for Fibromyalgia Completed NCT01287481 Phase 2
4 Ocytocine and Cerebral Activation in Relation With Attachement Recruiting NCT02847143 Phase 2
5 Autism Oxytocin Brain Project Recruiting NCT03033784 Phase 2
6 MDMA-assisted Therapy for Social Anxiety in Autistic Adults Active, not recruiting NCT02008396 Phase 2
7 Early Study of N-Acetylcysteine to Treat Deliberate Self-Harm in Adolescents Completed NCT01111734 Phase 1
8 Neurobiological, Neuropsychological,Linguistic and Gestural Processes and Phenomena in Individuals With Alexithymia Unknown status NCT00830752
9 Psychological Impact in Diabetes: Intervention With Affect School and Basal Body Awareness Unknown status NCT01498614
10 Psychopathological Risk Factors Associated With Conversion From Mild Cognitive Impairment to Dementia Unknown status NCT01436552
11 The Emotion Builder: An Intervention for Emotional Deficits After Brain Injury Completed NCT02432300
12 Online Treatment of Trichotillomania Completed NCT02044237
13 Moderating Impact of Various Emotion Personality Factors on Salivary Cortisol Response to a TSST Completed NCT00451126
14 Effectiveness of Standard Emergency Department Psychiatric Treatment Associated With Treatment Delivery by a Suicide Prevention Center Completed NCT00641498
15 Service Member Fatigue and Lack of Motivation Following Concussion Completed NCT01496586
16 Attention Bias Modification Treatment for Warzone-Related Posttraumatic Stress Disorder (PTSD) Completed NCT01564667
17 Functional Neuroanatomy and Regional Metabolism Before and After Treatment With Duloxetine Completed NCT02658617
18 Depression Online Assessment and Therapy Completed NCT02112266
19 Stress Management for Irritable Bowel Syndrome Completed NCT01886027
20 Plasticity of the Compassionate Brain Completed NCT01833104
21 Positive Emotion Regulation Training in Children, Adolescents and Young Adults With and Without Developmental Disorder Recruiting NCT02898298
22 A SYNdemic BASed INtervention for MSM With High Risk Behavior: Design of a Randomized Controlled Trial Recruiting NCT02859935
23 Mental Training for CFS Following EBV Infection in Adolescents Recruiting NCT02499302
24 Oculomotor Markers and Attachment in Adolescents Recruiting NCT02851810
25 Randomized Controlled Study of the Efficacy of Hypnosis Versus Relaxation and Control in Neuropathic Pain Recruiting NCT02256371
26 Student Outcomes of Integrative Mental Health Services Recruiting NCT02877875
27 Halifax Treatment Refractory Depression Trial Active, not recruiting NCT01141426
28 Mindfulness for Irritable Bowel Syndrome Active, not recruiting NCT02794376
29 Psychological Variables and Hyperglycemia in Diabetes Mellitus Enrolling by invitation NCT01714986
30 CBT-Eb Plus EMDR Versus CBT-Eb in Patients With Eating Disorders Not yet recruiting NCT03156959

Search NIH Clinical Center for Alexithymia

Genetic Tests for Alexithymia

Anatomical Context for Alexithymia

MalaCards organs/tissues related to Alexithymia:

39
Brain, Testes, Breast, Heart, Cortex, Skin, Thyroid

Publications for Alexithymia

Articles related to Alexithymia:

(show top 50) (show all 637)
id Title Authors Year
1
The mediating effects of cognitive emotion regulation strategies on the relationship between alexithymia and physical symptoms: Evidence from Iranian asthmatic patients. ( 27898375 )
2017
2
Reductions in Alexithymia and Emotion Dysregulation After Training Emotional Self-Awareness Following Traumatic Brain Injury: A Phase I Trial. ( 28060205 )
2017
3
Alexithymia as a Moderator of Treatment Outcomes in a Randomized Controlled Trial on Brief Psychodynamic Interpersonal Psychotherapy for Patients with Multisomatoform Disorder. ( 27884003 )
2017
4
Alexithymia in patients with type 2 diabetes mellitus: the role of anxiety, depression, and glycemic control. ( 27499615 )
2016
5
Corrigendum to "DRD2/ANKK1 TaqI A genotype moderates the relationship between alexithymia and the relative value of alcohol among male college binge drinkers" [Pharmacol. Biochem. Behav. 102 (2012) 471-476]. ( 27045283 )
2016
6
Describe Your Feelings: Body Illusion Related to Alexithymia in Adolescence. ( 27840618 )
2016
7
The Big Five personality dimensions and mental health: The mediating role of alexithymia. ( 27931909 )
2016
8
Predictors for DSM-5 nonsuicidal self-injury in female adolescent inpatients: The role of childhood maltreatment, alexithymia, and dissociation. ( 27088878 )
2016
9
Alexithymia, not autism, is associated with impaired interoception. ( 27253723 )
2016
10
Alexithymia, empathy, emotion identification and social inference in anorexia nervosa: A case-control study. ( 27086047 )
2016
11
Reduced anticipation of negative emotional events in alexithymia. ( 27278856 )
2016
12
Association between the Catechol-O-Methyltransferase (COMT) ValA^a8/a8,Met Polymorphism and Alexithymia in Patients with Obsessive-Compulsive Disorder. ( 26996573 )
2016
13
Borderline Personality Disorder Symptoms in College Students: The Complex Interplay between Alexithymia, Emotional Dysregulation and Rumination. ( 27348858 )
2016
14
Extreme sensory processing patterns show a complex association with depression, and impulsivity, alexithymia, and hopelessness. ( 28064114 )
2016
15
Interpersonal-Psychological Theory, Alexithymia, and Personality Predict Suicide Ideation among Maladjusted Soldiers in Taiwan. ( 27883207 )
2016
16
Empathy in depression: Egocentric and altercentric biases and the role of alexithymia. ( 27060429 )
2016
17
Examining the Effects of Alexithymia on the Relation Between Posttraumatic Stress Disorder and Over-Reporting. ( 27268098 )
2016
18
Touching the Lived Body in Patients with Medically Unexplained Symptoms. How an Integration of Hands-on Bodywork and Body Awareness in Psychotherapy may Help People with Alexithymia. ( 26973560 )
2016
19
Apathy, alexithymia, and depressive symptoms: Points of convergence and divergence. ( 27512920 )
2016
20
Alexithymia in Chronic Pain Disorders. ( 27215759 )
2016
21
Commentary: Alexithymia, not autism, is associated with impaired interoception. ( 27501009 )
2016
22
Alexithymia: a general deficit of interoception. ( 27853532 )
2016
23
Alterations in the Emotional Regulation Process in Gambling Addiction: The Role of Anger and Alexithymia. ( 27550365 )
2016
24
Cross-cultural validation of the 20-item Toronto Alexithymia Scale in Chinese adolescents. ( 27028136 )
2016
25
Exploring the interrelationship between alexithymia, defense style, emotional suppression, homicide-related posttraumatic stress disorder and psychiatric co-morbidity. ( 27449006 )
2016
26
An Examination of the Topology and Measurement of the Alexithymia Construct Using Network Analysis. ( 27217088 )
2016
27
Impulsivity, alexithymia and dissociation among pathological gamblers in different therapeutic settings: A multisample comparison study. ( 28029440 )
2016
28
Childhood Trauma and Alexithymia in Patients with Conversion Disorder. ( 27504555 )
2016
29
Default Mode Network alterations in alexithymia: an EEG power spectra and connectivity study. ( 27845326 )
2016
30
Individual differences in emotional processing and autobiographical memory: interoceptive awareness and alexithymia in the fading affect bias. ( 27556549 )
2016
31
Possible common neurological breakdowns for alexithymia and humour appreciation deficit: A case study. ( 27987387 )
2016
32
Predicting symptoms in major depression after inpatient treatment: the role of alexithymia. ( 26935972 )
2016
33
Alexithymia, but not autism spectrum disorder, may be related to the production of emotional facial expressions. ( 27895883 )
2016
34
Alexithymia and Emotional Processing: A Mediation Model. ( 28026885 )
2016
35
The association between depression and craving in alcohol dependency is moderated by gender and by alexithymia factors. ( 27137959 )
2016
36
Health-related quality of life and its association with alexithymia and difficulties in emotion regulation in patients with psoriasis. ( 27565774 )
2016
37
Alexithymia and psychopathological symptoms in adolescent outpatients and mothers suffering from migraines: a case control study. ( 27093870 )
2016
38
Alexithymia and psychopathology in patients with acute myocardial infarction. ( 27090044 )
2016
39
Investigation of facial emotion recognition, alexithymia, and levels of anxiety and depression in patients with somatic symptoms and related disorders. ( 27199559 )
2016
40
Effects of alexithymia and empathy on the neural processing of social and monetary rewards. ( 27866269 )
2016
41
Alexithymia and psychosocial problems among Italian preadolescents. A latent class analysis approach. ( 27376760 )
2016
42
From Childhood Trauma to Adult Dissociation: The Role of PTSD and Alexithymia. ( 27623153 )
2016
43
Alexithymia in Parkinson's disease: A systematic review of the literature. ( 27086264 )
2016
44
Relationship between internet addiction and alexithymia among university students. ( 27917803 )
2016
45
Impaired emotion recognition is linked to alexithymia in heroin addicts. ( 27069803 )
2016
46
Taking time to feel our body: Steady increases in heartbeat perception accuracy and decreases in alexithymia over 9 months of contemplative mental training. ( 27925645 )
2016
47
What's in the name 'alexithymia'? A commentary on "Affective agnosia: Expansion of the alexithymia construct and a new opportunity to integrate and extend Freud's legacy.". ( 27235080 )
2016
48
The role of alexithymia: An 8-year follow-up study of chronic pain patients. ( 27423355 )
2016
49
Prevalence and Demographic Correlates of Alexithymia: A Comparison Between Australian Psychiatric and Community Samples. ( 27129142 )
2016
50
Psychological Distress Mediates the Effect of Alexithymia on 2-Year Change in HIV Viral Load. ( 27882489 )
2016

Variations for Alexithymia

Expression for Alexithymia

Search GEO for disease gene expression data for Alexithymia.

GO Terms for Alexithymia

Biological processes related to Alexithymia according to GeneCards Suite gene sharing:

id Name GO ID Score Top Affiliating Genes
1 response to organic cyclic compound GO:0014070 9.5 COMT IL4 OXTR
2 response to cytokine GO:0034097 9.48 IL4 OXTR
3 social behavior GO:0035176 9.46 OXTR SLC6A4
4 response to cocaine GO:0042220 9.43 DRD2 OXTR
5 response to amphetamine GO:0001975 9.4 DRD2 OXTR
6 vasoconstriction GO:0042310 9.37 HTR1A SLC6A4
7 female pregnancy GO:0007565 9.33 COMT IL4 OXTR
8 dopamine metabolic process GO:0042417 9.26 COMT DRD2
9 response to drug GO:0042493 9.02 COMT DRD2 IL4 OXTR SLC6A4
10 sperm ejaculation GO:0042713 8.96 OXTR SLC6A4

Molecular functions related to Alexithymia according to GeneCards Suite gene sharing:

id Name GO ID Score Top Affiliating Genes
1 G-protein coupled receptor activity GO:0004930 9.26 DRD2 HTR1A OXTR TAS2R38
2 signal transducer activity GO:0004871 8.92 DRD2 HTR1A OXTR TAS2R38

Sources for Alexithymia

3 CDC
7 CNVD
9 Cosmic
10 dbSNP
11 DGIdb
16 ExPASy
18 FMA
28 GO
29 GTR
30 HGMD
31 HMDB
32 HPO
33 ICD10
34 ICD10 via Orphanet
35 ICD9CM
36 IUPHAR
37 KEGG
38 LifeMap
40 MedGen
42 MeSH
43 MESH via Orphanet
44 MGI
46 NCI
47 NCIt
48 NDF-RT
51 NINDS
52 Novoseek
54 OMIM
55 OMIM via Orphanet
59 PubMed
60 QIAGEN
65 SNOMED-CT via Orphanet
67 TGDB
68 Tocris
69 UMLS
70 UMLS via Orphanet
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