Aliases & Classifications for Alexithymia

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Alexithymia, Aliases & Descriptions:

Name: Alexithymia 9 11


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Disease Ontology9 DOID:0060131

Summaries for Alexithymia

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Wikipedia:63 Alexithymia /?e?l?ks???a?mi?/ is a personality construct characterized by the sub-clinical inability to... more...

MalaCards based summary: Alexithymia is related to eating disorder and personality disorder. An important gene associated with Alexithymia is ANKK1 (ankyrin repeat and kinase domain containing 1), and among its related pathways are Cytokines and Inflammatory Response and IL-9 Signaling and its Primary Biological Effects in Different Immune Cell Types. The compounds antipsychotics and methylphenidate have been mentioned in the context of this disorder. Affiliated tissues include brain, testes and breast, and related mouse phenotypes are cardiovascular system and digestive/alimentary.

Disease Ontology:9 An agnosia that is a deficiency in understanding, processing, or describing emotions.

Related Diseases for Alexithymia

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Diseases related to Alexithymia via text searches within MalaCards or GeneCards Suite gene sharing:

(show top 50)    (show all 145)
idRelated DiseaseScoreTop Affiliating Genes
1eating disorder31.0COMT, SLC6A4
2personality disorder31.0SLC6A4, DRD2, TTF2
3fibromyalgia30.8COMT, SLC6A4
4panic disorder30.8SLC6A4, COMT, TTF2
5pathological gambling30.7DRD2
6alcohol dependence30.7ANKK1, DRD2, SLC6A4
7generalized anxiety disorder30.7SLC6A4
8borderline personality disorder30.6TTF2, SLC6A4
9substance dependence30.6SLC6A4, DRD2, COMT
10obsessive-compulsive disorder30.3TTF2, COMT, DRD2, SLC6A4
11schizophrenia30.3TTF2, COMT, DRD2, SLC6A4
12asthma30.2IL4, CCL4, CCR5, CCL3, TTF2
13migraine30.2COMT, DRD2, SLC6A4
14mood disorder30.2COMT, DRD2, SLC6A4
15cocaine dependence30.1DRD2, SLC6A4
16anxiety disorder30.0TTF2, COMT, DRD2, SLC6A4
17alcohol abuse30.0SLC6A4, DRD2, COMT
18attention deficit-hyperactivity disorder30.0COMT, DRD2, SLC6A4
19breast cancer29.9DRD2, COMT, CCL4, CCR5, CCL3, TTF2
20antisocial personality disorder29.9TTF2, ANKK1, DRD2, SLC6A4
21obesity29.8TTF2, IL6, COMT, CRP, DRD2
22psychotic disorder29.8TTF2, COMT, DRD2, SLC6A4
23inflammatory bowel disease29.5CRP, IL6, IL4, CCR5
24myocardial infarction29.5CCL3, CCR5, COMT, CRP, SLC6A4
25atherosclerosis29.3CRP, COMT, IL6, CCL4, CCR5
26systemic lupus erythematosus29.2CCL3, CCR5, CCL4, IL4, IL6, CRP
27rheumatoid arthritis28.9CCL3, CCR5, CCL4, IL4, IL6, CRP
28arthritis28.7TTF2, CCL3, CCR5, CCL4, IL4, IL6
29aspergillosis10.5CCL3
30neuroleptic malignant syndrome10.4DRD2
31bronchiolitis10.4CCL3
32somatoform disorder10.4
33brain injury10.4
34traumatic brain injury10.4
35heroin dependence10.3ANKK1, DRD2
36dengue disease10.3CCL4, CCL3
37human immunodeficiency virus infectious disease10.3CCL4, CCL3
38drug addiction10.3COMT, DRD2
39lyme disease10.3CCL4, CCL3
40toxic shock syndrome10.3CCL3, CCL4
41anorexia nervosa10.3
42aortic aneurysm10.3CRP
43bacteriuria10.3CRP
44bulimia nervosa10.2SLC6A4, COMT
45pulmonary eosinophilia10.2CCL3, IL4
46cocaine abuse10.2SLC6A4, DRD2
47chronic pain10.2
48drug dependence10.2DRD2, SLC6A4
49encephalitis10.2CCL3, CCR5, CCL4
50sarcoidosis 110.2CCL3, CCR5, CCL4

Graphical network of the top 20 diseases related to Alexithymia:



Diseases related to alexithymia

Symptoms for Alexithymia

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Drugs & Therapeutics for Alexithymia

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Drug clinical trials:

Search ClinicalTrials for Alexithymia

Search NIH Clinical Center for Alexithymia

Genetic Tests for Alexithymia

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Anatomical Context for Alexithymia

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MalaCards organs/tissues related to Alexithymia:

31
Brain, Testes, Breast, Cortex, Heart, Thyroid, Eye, Colon, Kidney, Lung, Skin, Prefrontal cortex, Cingulate cortex, Globus pallidus, Subthalamic nucleus, Pituitary

Animal Models for Alexithymia or affiliated genes

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MGI Mouse Phenotypes related to Alexithymia:

35
idDescriptionMGI Source AccessionScoreTop Affiliating Genes
1MP:00053858.5SLC6A4, DRD2, CRP, COMT, IL6, CCR5
2MP:00053818.0CCL3, CCR5, IL4, IL6, DRD2
3MP:00053877.7CCL3, CCR5, IL4, IL6, COMT, CRP
4MP:00036317.6CCL3, CCR5, IL4, IL6, COMT, DRD2
5MP:00053767.4SLC6A4, CCL3, CCR5, IL4, IL6, COMT

Publications for Alexithymia

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Articles related to Alexithymia:

(show top 50)    (show all 548)
idTitleAuthorsYear
1
Who takes risks in high-risk sport?: the role of alexithymia. (25730894)
2015
2
Common and distinct impacts of autistic traits and alexithymia on social reward. (25853670)
2015
3
Facial and Bodily Emotion Recognition in Multiple Sclerosis: The Role of Alexithymia and Other Characteristics of the Disease. (25373767)
2014
4
Caffeine use and alexithymia in university students. (25188705)
2014
5
Alexithymia impact on type 1 and type 2 diabetes: a case-control study. (25148784)
2014
6
Distinct associations of insula and cingulate volume with the cognitive and affective dimensions of alexithymia. (24334109)
2013
7
Alexithymia and personality in relation to social anxiety among university students. (23246382)
2013
8
HPA system activity in alexithymia: a cortisol awakening response study. (23627992)
2013
9
I don't know how I feel, therefore I act: alexithymia, urgency, and alcohol problems. (23384454)
2013
10
Stress coping strategies in patients with psychogenic non-epileptic seizures and how they relate to trauma symptoms, alexithymia, anger and mood. (23689067)
2013
11
The relationship between attachment styles and alexithymia: Mediating role of defense mechanisms. (24309875)
2013
12
Alexithymia, emotional empathy, and self-regulation in anorexia nervosa. (23638441)
2013
13
A family history of alcoholism relates to alexithymia in substance use disorder patients. (23642633)
2013
14
Brain response during visual emotional processing: an fMRI study of alexithymia. (23850105)
2013
15
Alexithymia, not autism, predicts poor recognition of emotional facial expressions. (23528789)
2013
16
Alexithymia as a mediator between attachment and the development of borderline personality disorder in adolescence. (23013337)
2012
17
Alexithymia is associated with an augmenter profile, but not only: evidence for anticipation to arousing music. (22962856)
2012
18
Alexithymia in severe idiopathic scoliosis: findings from a cross-sectional study of adolescents who have or have not had operations. (22373771)
2012
19
Alexithymia and alcohol consumption: the mediating effects of drinking motives. (22154505)
2012
20
Alexithymia in healthy young men: a voxel-based morphometric study. (21723620)
2012
21
Alexithymia and dependent personality disorder. (22349651)
2012
22
Alexithymia is a non-motor symptom of Parkinson disease. (22273734)
2012
23
A naturalistic study of alexithymia among psychiatric outpatients treated in an integrated group therapy program. (22903919)
2012
24
Associations between facial emotion recognition, cognition and alexithymia in patients with schizophrenia: comparison of photographic and virtual reality presentations. (22954834)
2012
25
Child maltreatment, subsequent non-suicidal self-injury and the mediating roles of dissociation, alexithymia and self-blame. (22858062)
2012
26
Alexithymia in Chinese chronic obstructive pulmonary disease (COPD) patients: the prevalence and related factors of alexithymia. (22401970)
2012
27
The relationship between alexithymia and maladaptive perfectionism in eating disorders: a mediation moderation analysis methodology. (22290034)
2011
28
Alexithymia, craving and attachment in a heavy drinking population. (21215527)
2011
29
Impact of childhood trauma, alexithymia, dissociation, and emotion suppression on emotional Stroop task. (21193101)
2011
30
Interaction effect of functional variants of the BDNF and DRD2/ANKK1 gene is associated with alexithymia in healthy human subjects. (21097659)
2011
31
Alexithymia in neurodegenerative disease. (21432723)
2011
32
Distress and alexithymia in lung recipients - psychosocial strains and associations with chronic allograft dysfunction. (20175005)
2010
33
Alexithymia and temperament and character model of personality in patients with major depressive disorder. (19932828)
2010
34
Commentary on the paper "Is alexithymia a risk factor for major depression, personality disorder, or alcohol use disorders? A prospective population-based study". (20159213)
2010
35
Disease outcome, alexithymia and depression are differently associated with serum IL-18 levels in acute stroke. (19534720)
2009
36
Alexithymia, temperament and character as predictors of psychopathology in patients with major depression. (19084277)
2009
37
Alexithymia and fear of pain independently predict heat pain intensity ratings among undergraduate university students. (19714270)
2009
38
Alexithymia, absorption, and cognitive failures in depersonalization disorder: a comparison to posttraumatic stress disorder and healthy volunteers. (19597356)
2009
39
Alexithymia and therapist reactions to the patient: expression of positive emotion as a mediator. (18834276)
2008
40
Alexithymia and cognitive dysfunctions in patients with panic disorder. (18332616)
2008
41
Self-injurious behaviour, traumatic life events and alexithymia among treatment-seeking opiate addicts: prevalence, pattern and correlates. (18639391)
2008
42
Relationship between diary-keeping and tendencies toward alexithymia and rumination. (19320211)
2008
43
No words for feelings: alexithymia in schizophrenia patients and first-degree relatives. (17145278)
2007
44
Regulation of emotions during experimental stress in alexithymia. (17540222)
2007
45
Alexithymia, somatization and negative affect in a community sample. (17258817)
2007
46
Empathy and judging other's pain: an fMRI study of alexithymia. (17150987)
2007
47
Factors related to anxiety and depression in women with breast cancer and their husbands: role of alexithymia and family functioning. (17216201)
2007
48
Response to "Letter to the Editor: The overlap between alexithymia and Asperger's syndrome", Fitzgerald and Bellgrove, Journal of Autism and Developmental Disorders, 36(4). (17080269)
2006
49
Alexithymia and PTSD symptoms in urban police officers: cross-sectional and prospective findings. (16788996)
2006
50
Predicting resistance to stress: incremental validity of trait emotional intelligence over alexithymia and optimism. (17295962)
2006

Variations for Alexithymia

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Expression for genes affiliated with Alexithymia

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Search GEO for disease gene expression data for Alexithymia.

Pathways for genes affiliated with Alexithymia

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Pathways related to Alexithymia according to GeneCards Suite gene sharing:

(show all 16)
idSuper pathways (with members indented)ScoreTop Affiliating Genes
19.7IL6, IL4
29.7IL6, IL4
39.7IL6, IL4
4
Show member pathways
9.4IL6, IL4, CCR5
5
Show member pathways
BCR signaling pathway36
TCR Signaling Pathway36
9.4CCR5, IL4, IL6
6
Show member pathways
9.0CCL4, CCL3
7
Show member pathways
8.7CCL3, CCR5, CCL4
8
Show member pathways
8.7CCL3, CCR5, CCL4
9
Show member pathways
8.6CCL3, CCL4, IL6
10
Show member pathways
Immune response IL 12 induced IFN gamma production58
8.4IL4, CCL4, CCR5, CCL3
11
Show member pathways
8.3CCL3, CCL4, IL4, IL6
12
Show member pathways
8.2DRD2, CCL4, CCR5, CCL3, WNT10A
13
Show member pathways
8.0CCL3, CCR5, CCL4, IL4, IL6
14
Show member pathways
8.0CCL3, CCR5, CCL4, IL4, IL6
15
Show member pathways
8.0CCL3, CCR5, CCL4, IL4, IL6
16
Show member pathways
8.0CCL3, CCR5, CCL4, IL4, IL6

Compounds for genes affiliated with Alexithymia

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Compounds related to Alexithymia according to GeneCards Suite gene sharing:

(show top 50)    (show all 118)
idCompoundScoreTop Affiliating Genes
1antipsychotics4910.0COMT, DRD2, ANKK1
2methylphenidate43 49 1211.9SLC6A4, DRD2, COMT
3maoa439.9COMT, DRD2, SLC6A4
4methadone49 43 1211.8DRD2, CCR5, ANKK1, TTF2
5heroin43 49 1211.8COMT, DRD2, SLC6A4
6bupropion49 43 24 1212.8ANKK1, COMT, DRD2, SLC6A4
7risperidone43 49 28 59 24 1214.8COMT, DRD2, ANKK1, SLC6A4
8olanzapine43 49 28 24 1213.8DRD2, COMT, SLC6A4, ANKK1
9ketamine43 28 1211.7SLC6A4, DRD2, CRP
10nicotine43 28 49 1212.5ANKK1, COMT, TTF2, DRD2, SLC6A4
11okt3439.5CRP, IL6, IL4
12amphotericin b439.4CCL4, CRP, IL4
13clozapine43 28 49 1212.4SLC6A4, CRP, COMT, DRD2, ANKK1
14morphine43 49 28 1212.3DRD2, CCL4, CCR5, COMT
15isopentenyl diphosphate43 2810.1CCL4, CCR5, CCL3
16norepinephrine43 24 1211.1IL6, COMT, SLC6A4, CRP, DRD2
17pmma439.1CRP, IL6, CCL3
18methacholine43 49 1211.1IL4, TTF2, CCL3, CRP
19mdms439.1CCL3, CCR5, CCL4
20larc439.1CCR5, CCL3, CCL4
21methylcellulose439.0IL6, IL4, CCL3, CCR5
22anaphylatoxin439.0IL6, IL4, CCL3
23mcp 1439.0CCL3, CCL4, IL6
24neopterin438.9CRP, IL6, IL4, CCL3
25cocaine43 129.9CCR5, COMT, DRD2, CCL3, SLC6A4
26gm-csf43 289.9CCL3, IL6, IL4
27polyinosinic-polycytidylic acid438.9IL6, CCL3, IL4
28ivig438.9CCR5, CCL4, IL4, IL6, CRP
29ritonavir43 49 1210.8CCL3, IL4, CCL4, CCR5
30tarc438.8CCR5, CCL3, CCL4, IL4
31groalpha438.8CCL4, IL6, CCR5, CCL3
32ccl343 289.7CCR5, CCL4, CCL3, IL6
33epinephrine43 24 1210.7DRD2, COMT, SLC6A4, CCL3, IL6
348-isoprostane438.6CRP, IL6, CCL3
35triptolide438.5IL6, CCL4, CCL3
36prednisolone43 28 1210.5IL6, CCL4, CCL3, CRP
37mip 1alpha438.4CCL4, CCR5, IL4, IL6, CCL3
38il 10438.4CCL3, CCR5, CCL4, IL4, IL6
39rantes438.4CCL3, IL4, CCL4, IL6, CCR5
40endotoxin438.3CRP, IL6, CCL4, CCL3
41histamine43 28 2410.3CCL3, IL4, CCR5, IL6, CCL4
42sb 20358043 599.3IL6, CCL3, CCL4, IL4, CRP
43pge2438.2CCL4, IL4, CCL3, CCR5, IL6
44cyclosporin a43 28 5910.2IL4, CCL4, CCR5, CCL3, TTF2, IL6
45cholesterol43 28 24 1211.0CRP, CCL3, CCR5, IL6, CCL4, TTF2
46dexamethasone43 49 28 1211.0CCR5, IL6, IL4, CCL4, CCL3, TTF2
47cysteine437.9COMT, CCR5, TTF2, SLC6A4, CCL4, CCL3
48alanine437.8TTF2, CCL3, CCR5, CCL4, IL6, CRP
49vegf437.8CCL3, CCL4, IL4, IL6, TTF2, CRP
50simvastatin43 49 59 28 24 1212.7CCR5, CCL4, SLC6A4, IL6, CRP, CCL3

GO Terms for genes affiliated with Alexithymia

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Cellular components related to Alexithymia according to GeneCards Suite gene sharing:

idNameGO IDScoreTop Affiliating Genes
1external side of plasma membraneGO:00098979.4IL6, IL4, CCR5
2extracellular spaceGO:00056157.4CRP, IL6, IL4, CCL4, CCL3, WNT10A

Biological processes related to Alexithymia according to GeneCards Suite gene sharing:

(show all 20)
idNameGO IDScoreTop Affiliating Genes
1negative regulation of lipid storageGO:001088810.0CRP, IL6
2defense response to protozoanGO:00428329.9IL4, IL6
3signalingGO:00230529.7CCR5, CCL3
4release of sequestered calcium ion into cytosol by sarcoplasmic reticulumGO:00148089.7CCL3, CCR5
5response to cholesterolGO:00707239.6CCR5, CCL3
6response to hypoxiaGO:00016669.6CRP, DRD2, SLC6A4
7defense response to Gram-positive bacteriumGO:00508309.4CRP, IL6
8monocyte chemotaxisGO:00025489.4IL6, CCL3
9negative regulation of osteoclast differentiationGO:00456719.4IL4, CCL3
10positive regulation of natural killer cell chemotaxisGO:020005039.3CCL4, CCL3
11negative regulation by host of viral transcriptionGO:00439229.3CCL4, CCL3
12positive regulation of gene expressionGO:00106289.3SLC6A4, CCL3, WNT10A
13chemotaxisGO:00069359.2IL4, CCR5, CCL3
14positive regulation of ERK1 and ERK2 cascadeGO:00703749.2CCL3, IL6, DRD2
15response to drugGO:00424939.2IL4, IL6, COMT, DRD2, SLC6A4
16positive regulation of calcium-mediated signalingGO:00508509.0CCL4, CCL3
17positive regulation of calcium ion transportGO:00519288.9CCL3, CCL4
18cell-cell signalingGO:00072678.7CCL4, CCR5, CCL3
19response to toxic substanceGO:00096368.7SLC6A4, DRD2, CCL4, CCL3
20inflammatory responseGO:00069548.3CCL3, CCR5, CCL4, IL6, CRP

Molecular functions related to Alexithymia according to GeneCards Suite gene sharing:

idNameGO IDScoreTop Affiliating Genes
1cytokine activityGO:00051259.1IL6, IL4, CCL4
2CCR1 chemokine receptor bindingGO:00317269.0CCL4, CCL3
3CCR5 chemokine receptor bindingGO:00317308.9CCL4, CCL3
4protein bindingGO:00055155.9AVEN, TTF2, CCL3, CCR5, CCL4, IL4

Products for genes affiliated with Alexithymia

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Sources for Alexithymia

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3CDC
13ExPASy
14FMA
22GTR
23HGMD
24HMDB
25ICD10
26ICD10 via Orphanet
27ICD9CM
28IUPHAR
29KEGG
33MeSH
34MESH via Orphanet
35MGI
38NCIt
39NDF-RT
42NINDS
43Novoseek
45OMIM
46OMIM via Orphanet
50PubMed
51QIAGEN
56SNOMED-CT via Orphanet
60UMLS
61UMLS via Orphanet