MCID: ALX002
MIFTS: 51

Alexithymia malady

Fetal diseases category
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Summaries for Alexithymia

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8Disease Ontology, 65Wikipedia, 33MalaCards
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Wikipedia:65 Alexithymia /?e?l?ks???a?mi?/ is a personality construct characterized by the sub-clinical inability to... more...

MalaCards: Alexithymia is related to personality disorder and eating disorder. An important gene associated with Alexithymia is ANKK1 (ankyrin repeat and kinase domain containing 1), and among its related pathways are Cytokines and Inflammatory Response and IL-9 Signaling and its Primary Biological Effects in Different Immune Cell Types. The compounds antipsychotics and methylphenidate have been mentioned in the context of this disorder. Affiliated tissues include brain, breast and testes, and related mouse phenotypes are cardiovascular system and digestive/alimentary.

Disease Ontology:8 An agnosia that is a deficiency in understanding, processing, or describing emotions.

Aliases & Classifications for Alexithymia

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8Disease Ontology, 10DISEASES
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Classifications:

Malacards categories (disease lists): (See all malacards categories)
Global: Fetal diseases


Aliases & Descriptions:

alexithymia 8 10


External Ids:

Disease Ontology8 DOID:0060131

Related Diseases for Alexithymia

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Sources:
17GeneCards, 18GeneDecks
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Diseases related to Alexithymia via text searches within MalaCards or GeneCards/GeneDecks gene sharing:

(show top 50)    (show all 147)
idRelated DiseaseScoreTop Affiliating Genes
1personality disorder30.8SLC6A4, DRD2, TTF2
2eating disorder30.8SLC6A4, COMT
3panic disorder30.6SLC6A4, TTF2, COMT
4alcohol dependence30.6ANKK1, DRD2, SLC6A4
5fibromyalgia30.6COMT, SLC6A4
6substance dependence30.5SLC6A4, DRD2, COMT
7asthma30.4IL4, CCL4, CCR5, TTF2, CCL3
8schizophrenia30.4SLC6A4, DRD2, COMT, TTF2
9obsessive-compulsive disorder30.3DRD2, COMT, TTF2, SLC6A4
10borderline personality disorder30.3SLC6A4, TTF2
11breast cancer30.3TTF2, CCL4, CCL3, COMT, DRD2, CCR5
12pathological gambling30.2DRD2
13migraine30.2SLC6A4, COMT, DRD2
14obesity30.2CRP, TTF2, COMT, DRD2, IL6
15mood disorder30.1COMT, SLC6A4, DRD2
16generalized anxiety disorder30.0SLC6A4
17myocardial infarction29.9CCL3, SLC6A4, CRP, COMT, CCR5
18cocaine dependence29.9DRD2, SLC6A4
19alcohol abuse29.9SLC6A4, DRD2, COMT
20attention deficit hyperactivity disorder29.9SLC6A4, DRD2, COMT
21antisocial personality disorder29.8ANKK1, TTF2, DRD2, SLC6A4
22systemic lupus erythematosus29.8IL4, CCL4, CRP, CCL3, CCR5, IL6
23multiple sclerosis29.8CCL4, IL4, IL6, COMT, CCR5, DRD2
24hypertension29.8SLC6A4, CRP
25anxiety disorder29.8SLC6A4, COMT, DRD2, TTF2
26psychotic disorder29.8COMT, SLC6A4, DRD2, TTF2
27inflammatory bowel disease29.7IL6, IL4, CCR5, CRP
28atherosclerosis29.7IL6, CCR5, CCL4, CRP, COMT
29rheumatoid arthritis29.6IL6, CRP, IL4, CCL4, CCL3, CCR5
30arthritis29.6CRP, TTF2, CCL3, CCR5, IL4, IL6
31parkinson's disease10.4
32somatoform disorder10.4
33brain injury10.3
34traumatic brain injury10.3
35major depressive disorder10.2
36anorexia nervosa10.2
37chronic pain10.2
38post-traumatic stress disorder10.1
39urticaria10.1
40back pain10.1
41aspergillosis10.1CCL3
42neuroleptic malignant syndrome10.1DRD2
43bronchiolitis10.1CCL3
44heroin dependence10.1DRD2, ANKK1
45dengue disease10.1CCL3, CCL4
46human immunodeficiency virus infectious disease10.1CCL3, CCL4
47lyme disease10.1CCL3, CCL4
48toxic shock syndrome10.1CCL3, CCL4
49bacteriuria10.1CRP
50aortic aneurysm10.1CRP

Graphical network of the top 20 diseases related to Alexithymia:



Diseases related to alexithymia

Symptoms for Alexithymia

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Drugs & Therapeutics for Alexithymia

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Sources:
42NIH Clinical Center, 6ClinicalTrials
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Drug clinical trials:

Search ClinicalTrials for Alexithymia

Search NIH Clinical Center for Alexithymia

Genetic Tests for Alexithymia

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Anatomical Context for Alexithymia

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33MalaCards
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MalaCards organs/tissues related to Alexithymia:

33
Brain, Breast, Testes, Heart, Cortex, Thyroid, Skin, Prefrontal cortex, Globus pallidus, Colon, Eye, Lung, Cingulate cortex

Animal Models for Alexithymia or affiliated genes

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37MGI
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MGI Mouse Phenotypes related to Alexithymia:

37
idDescriptionMGI Source AccessionScoreTop Affiliating Genes
1MP:00053858.5DRD2, CRP, COMT, IL6, CCR5, SLC6A4
2MP:00053818.0CCL3, CCR5, IL4, IL6, DRD2
3MP:00053877.7CCR5, IL4, IL6, DRD2, CCL3, CRP
4MP:00036317.6SLC6A4, DRD2, COMT, IL6, IL4, CCR5
5MP:00053767.4IL4, CCR5, IL6, COMT, CRP, DRD2

Publications for Alexithymia

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Sources:
52PubMed
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Articles related to Alexithymia:

(show top 50)    (show all 503)
idTitleAuthorsYear
1
Distinct associations of insula and cingulate volume with the cognitive and affective dimensions of alexithymia. (24334109)
2013
2
Alexithymia and personality in relation to social anxiety among university students. (23246382)
2013
3
HPA system activity in alexithymia: a cortisol awakening response study. (23627992)
2013
4
I don't know how I feel, therefore I act: alexithymia, urgency, and alcohol problems. (23384454)
2013
5
The relationship between attachment styles and alexithymia: Mediating role of defense mechanisms. (24309875)
2013
6
Alexithymia, emotional empathy, and self-regulation in anorexia nervosa. (23638441)
2013
7
A family history of alcoholism relates to alexithymia in substance use disorder patients. (23642633)
2013
8
Brain response during visual emotional processing: an fMRI study of alexithymia. (23850105)
2013
9
Alexithymia, not autism, predicts poor recognition of emotional facial expressions. (23528789)
2013
10
Effects of childhood trauma on somatization in major depressive disorder: The role of alexithymia. (22884234)
2013
11
Alexithymia as a mediator between attachment and the development of borderline personality disorder in adolescence. (23013337)
2012
12
Alexithymia is associated with an augmenter profile, but not only: evidence for anticipation to arousing music. (22962856)
2012
13
Alexithymia in severe idiopathic scoliosis: findings from a cross-sectional study of adolescents who have or have not had operations. (22373771)
2012
14
Alexithymia and alcohol consumption: the mediating effects of drinking motives. (22154505)
2012
15
Alexithymia in healthy young men: a voxel-based morphometric study. (21723620)
2012
16
Alexithymia and dependent personality disorder. (22349651)
2012
17
Alexithymia is a non-motor symptom of Parkinson disease. (22273734)
2012
18
A naturalistic study of alexithymia among psychiatric outpatients treated in an integrated group therapy program. (22903919)
2012
19
Associations between facial emotion recognition, cognition and alexithymia in patients with schizophrenia: comparison of photographic and virtual reality presentations. (22954834)
2012
20
Child maltreatment, subsequent non-suicidal self-injury and the mediating roles of dissociation, alexithymia and self-blame. (22858062)
2012
21
Alexithymia in Chinese chronic obstructive pulmonary disease (COPD) patients: the prevalence and related factors of alexithymia. (22401970)
2012
22
Alexithymia is not a stable personality trait in patients with substance use disorders. (22382053)
2012
23
The relationship between alexithymia and maladaptive perfectionism in eating disorders: a mediation moderation analysis methodology. (22290034)
2011
24
Alexithymia, craving and attachment in a heavy drinking population. (21215527)
2011
25
Impact of childhood trauma, alexithymia, dissociation, and emotion suppression on emotional Stroop task. (21193101)
2011
26
Interaction effect of functional variants of the BDNF and DRD2/ANKK1 gene is associated with alexithymia in healthy human subjects. (21097659)
2011
27
Alexithymia in neurodegenerative disease. (21432723)
2011
28
Evaluation of alexithymia and depression in severe obese patients not affected by eating disorders. (21727778)
2011
29
Distress and alexithymia in lung recipients - psychosocial strains and associations with chronic allograft dysfunction. (20175005)
2010
30
Alexithymia and temperament and character model of personality in patients with major depressive disorder. (19932828)
2010
31
Commentary on the paper "Is alexithymia a risk factor for major depression, personality disorder, or alcohol use disorders? A prospective population-based study". (20159213)
2010
32
Disease outcome, alexithymia and depression are differently associated with serum IL-18 levels in acute stroke. (19534720)
2009
33
Alexithymia, temperament and character as predictors of psychopathology in patients with major depression. (19084277)
2009
34
Alexithymia and fear of pain independently predict heat pain intensity ratings among undergraduate university students. (19714270)
2009
35
Alexithymia, absorption, and cognitive failures in depersonalization disorder: a comparison to posttraumatic stress disorder and healthy volunteers. (19597356)
2009
36
Alexithymia and pathological gambling. (20155587)
2009
37
Alexithymia and therapist reactions to the patient: expression of positive emotion as a mediator. (18834276)
2008
38
Alexithymia and cognitive dysfunctions in patients with panic disorder. (18332616)
2008
39
Self-injurious behaviour, traumatic life events and alexithymia among treatment-seeking opiate addicts: prevalence, pattern and correlates. (18639391)
2008
40
Relationship between diary-keeping and tendencies toward alexithymia and rumination. (19320211)
2008
41
No words for feelings: alexithymia in schizophrenia patients and first-degree relatives. (17145278)
2007
42
Regulation of emotions during experimental stress in alexithymia. (17540222)
2007
43
Alexithymia, somatization and negative affect in a community sample. (17258817)
2007
44
Empathy and judging other's pain: an fMRI study of alexithymia. (17150987)
2007
45
Factors related to anxiety and depression in women with breast cancer and their husbands: role of alexithymia and family functioning. (17216201)
2007
46
Alexithymia in chronic fatigue syndrome: associations with momentary, recall, and retrospective measures of somatic complaints and emotions. (17244849)
2007
47
Alexithymia and interpersonal problems. (17016830)
2007
48
Response to "Letter to the Editor: The overlap between alexithymia and Asperger's syndrome", Fitzgerald and Bellgrove, Journal of Autism and Developmental Disorders, 36(4). (17080269)
2006
49
Alexithymia and PTSD symptoms in urban police officers: cross-sectional and prospective findings. (16788996)
2006
50
Predicting resistance to stress: incremental validity of trait emotional intelligence over alexithymia and optimism. (17295962)
2006

Variations for Alexithymia

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Expression for genes affiliated with Alexithymia

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Sources:
2BioGPS, 15Gene Expression Omnibus DataSets
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Expression patterns in normal tissues for genes affiliated with Alexithymia

Search GEO for disease gene expression data for Alexithymia.

Pathways for genes affiliated with Alexithymia

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Sources:
50PathCards, 38NCBI BioSystems Database, 54R&D Systems, 53QIAGEN, 30KEGG, 55Reactome, 60Thomson Reuters
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Pathways related to Alexithymia according to GeneCards/GeneDecks:

(show all 16)
idSuper pathways (with members indented)ScoreTop Affiliating Genes
19.7IL6, IL4
29.7IL6, IL4
39.7IL6, IL4
4
Show member pathways
9.4IL6, IL4, CCR5
5
Show member pathways
BCR signaling pathway38
TCR Signaling Pathway38
9.4CCR5, IL4, IL6
6
Show member pathways
9.0CCL4, CCL3
7
Show member pathways
8.7CCL3, CCR5, CCL4
8
Show member pathways
8.7CCL3, CCR5, CCL4
9
Show member pathways
8.6CCL3, CCL4, IL6
10
Show member pathways
Immune response IL 12 induced IFN gamma production60
8.4IL4, CCL4, CCR5, CCL3
11
Show member pathways
8.3CCL3, CCL4, IL4, IL6
12
Show member pathways
8.2DRD2, CCL4, CCR5, CCL3, WNT10A
13
Show member pathways
8.0CCL3, CCR5, CCL4, IL4, IL6
14
Show member pathways
8.0CCL3, CCR5, CCL4, IL4, IL6
15
Show member pathways
8.0CCL3, CCR5, CCL4, IL4, IL6
16
Show member pathways
8.0CCL3, CCR5, CCL4, IL4, IL6

Compounds for genes affiliated with Alexithymia

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Sources:
51PharmGKB, 45Novoseek, 11DrugBank, 24HMDB, 29IUPHAR, 61Tocris Bioscience
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Compounds related to Alexithymia according to GeneCards/GeneDecks:

(show top 50)    (show all 118)
idCompoundScoreTop Affiliating Genes
1antipsychotics5110.0COMT, DRD2, ANKK1
2methylphenidate45 51 1111.9SLC6A4, DRD2, COMT
3maoa459.9COMT, DRD2, SLC6A4
4methadone51 45 1111.8DRD2, CCR5, ANKK1, TTF2
5heroin45 51 1111.8COMT, DRD2, SLC6A4
6bupropion51 45 24 1112.8ANKK1, COMT, DRD2, SLC6A4
7risperidone45 51 29 61 24 1114.8COMT, DRD2, ANKK1, SLC6A4
8olanzapine45 51 29 24 1113.8DRD2, COMT, SLC6A4, ANKK1
9ketamine45 29 1111.7SLC6A4, DRD2, CRP
10nicotine45 29 51 1112.5ANKK1, COMT, TTF2, DRD2, SLC6A4
11okt3459.5CRP, IL6, IL4
12amphotericin b459.4CCL4, CRP, IL4
13clozapine45 29 51 1112.4SLC6A4, CRP, COMT, DRD2, ANKK1
14morphine45 51 29 1112.3DRD2, CCL4, CCR5, COMT
15isopentenyl diphosphate45 2910.1CCL4, CCR5, CCL3
16norepinephrine45 24 1111.1IL6, COMT, SLC6A4, CRP, DRD2
17pmma459.1CRP, IL6, CCL3
18methacholine45 51 1111.1IL4, TTF2, CCL3, CRP
19mdms459.1CCL3, CCR5, CCL4
20larc459.1CCR5, CCL3, CCL4
21methylcellulose459.0IL6, IL4, CCL3, CCR5
22anaphylatoxin459.0IL6, IL4, CCL3
23mcp 1459.0CCL3, CCL4, IL6
24neopterin458.9CRP, IL6, IL4, CCL3
25cocaine45 119.9CCR5, COMT, DRD2, CCL3, SLC6A4
26gm-csf45 299.9CCL3, IL6, IL4
27polyinosinic-polycytidylic acid458.9IL6, CCL3, IL4
28ivig458.9CCR5, CCL4, IL4, IL6, CRP
29ritonavir45 51 1110.8CCL3, IL4, CCL4, CCR5
30tarc458.8CCR5, CCL3, CCL4, IL4
31groalpha458.8CCL4, IL6, CCR5, CCL3
32ccl345 299.7CCR5, CCL4, CCL3, IL6
33epinephrine45 24 1110.7DRD2, COMT, SLC6A4, CCL3, IL6
348-isoprostane458.6CRP, IL6, CCL3
35triptolide458.5IL6, CCL4, CCL3
36prednisolone45 29 1110.5IL6, CCL4, CCL3, CRP
37mip 1alpha458.4CCL4, CCR5, IL4, IL6, CCL3
38il 10458.4CCL3, CCR5, CCL4, IL4, IL6
39rantes458.4CCL3, IL4, CCL4, IL6, CCR5
40endotoxin458.3CRP, IL6, CCL4, CCL3
41histamine45 29 2410.3CCL3, IL4, CCR5, IL6, CCL4
42sb 20358045 619.3IL6, CCL3, CCL4, IL4, CRP
43pge2458.2CCL4, IL4, CCL3, CCR5, IL6
44cyclosporin a45 29 6110.2IL4, CCL4, CCR5, CCL3, TTF2, IL6
45cholesterol45 29 24 1111.0CRP, CCL3, CCR5, IL6, CCL4, TTF2
46dexamethasone45 51 29 1111.0CCR5, IL6, IL4, CCL4, CCL3, TTF2
47cysteine457.9COMT, CCR5, TTF2, SLC6A4, CCL4, CCL3
48alanine457.8TTF2, CCL3, CCR5, CCL4, IL6, CRP
49vegf457.8CCL3, CCL4, IL4, IL6, TTF2, CRP
50simvastatin45 51 61 29 24 1112.7CCR5, CCL4, SLC6A4, IL6, CRP, CCL3

GO Terms for genes affiliated with Alexithymia

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Sources:
16Gene Ontology
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Cellular components related to Alexithymia according to GeneCards/GeneDecks:

idNameGO IDScoreTop Affiliating Genes
1external side of plasma membraneGO:0098979.4IL6, IL4, CCR5
2extracellular spaceGO:0056157.4CRP, IL6, IL4, CCL4, CCL3, WNT10A

Biological processes related to Alexithymia according to GeneCards/GeneDecks:

(show all 20)
idNameGO IDScoreTop Affiliating Genes
1negative regulation of lipid storageGO:01088810.0CRP, IL6
2defense response to protozoanGO:0428329.9IL4, IL6
3signalingGO:0230529.7CCR5, CCL3
4release of sequestered calcium ion into cytosol by sarcoplasmic reticulumGO:0148089.7CCL3, CCR5
5response to cholesterolGO:0707239.6CCR5, CCL3
6response to hypoxiaGO:0016669.6CRP, DRD2, SLC6A4
7defense response to Gram-positive bacteriumGO:0508309.4CRP, IL6
8monocyte chemotaxisGO:0025489.4IL6, CCL3
9negative regulation of osteoclast differentiationGO:0456719.4IL4, CCL3
10positive regulation of natural killer cell chemotaxisGO:20005039.3CCL4, CCL3
11negative regulation by host of viral transcriptionGO:0439229.3CCL4, CCL3
12positive regulation of gene expressionGO:0106289.3SLC6A4, CCL3, WNT10A
13chemotaxisGO:0069359.2IL4, CCR5, CCL3
14positive regulation of ERK1 and ERK2 cascadeGO:0703749.2CCL3, IL6, DRD2
15response to drugGO:0424939.2IL4, IL6, COMT, DRD2, SLC6A4
16positive regulation of calcium-mediated signalingGO:0508509.0CCL4, CCL3
17positive regulation of calcium ion transportGO:0519288.9CCL3, CCL4
18cell-cell signalingGO:0072678.7CCL4, CCR5, CCL3
19response to toxic substanceGO:0096368.7SLC6A4, DRD2, CCL4, CCL3
20inflammatory responseGO:0069548.3CCL3, CCR5, CCL4, IL6, CRP

Molecular functions related to Alexithymia according to GeneCards/GeneDecks:

idNameGO IDScoreTop Affiliating Genes
1cytokine activityGO:0051259.1IL6, IL4, CCL4
2CCR1 chemokine receptor bindingGO:0317269.0CCL4, CCL3
3CCR5 chemokine receptor bindingGO:0317308.9CCL4, CCL3
4protein bindingGO:0055155.9AVEN, TTF2, CCL3, CCR5, CCL4, IL4

Products for genes affiliated with Alexithymia

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  • Antibodies
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Sources for Alexithymia

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4CDC
13ExPASy
14FMA
22GTR
23HGMD
24HMDB
25ICD10
26ICD10 via Orphanet
27ICD9CM
29IUPHAR
30KEGG
35MeSH
36MESH via Orphanet
37MGI
40NCIt
41NDF-RT
44NINDS
45Novoseek
47OMIM
48OMIM via Orphanet
52PubMed
53QIAGEN
59SNOMED-CT via Orphanet
62UMLS
63UMLS via Orphanet