MCID: ALX002
MIFTS: 51

Alexithymia malady

Fetal diseases category

Summaries for Alexithymia

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9Disease Ontology, 66Wikipedia, 34MalaCards
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Wikipedia:66 Alexithymia /?e?l?ks???a?mi?/ is a personality construct characterized by the sub-clinical inability to... more...

MalaCards: Alexithymia is related to personality disorder and eating disorder. An important gene associated with Alexithymia is ANKK1 (ankyrin repeat and kinase domain containing 1), and among its related pathways are Cytokines and Inflammatory Response and IL-9 Signaling and its Primary Biological Effects in Different Immune Cell Types. The compounds antipsychotics and methylphenidate have been mentioned in the context of this disorder. Affiliated tissues include brain, breast and testes, and related mouse phenotypes are cardiovascular system and digestive/alimentary.

Disease Ontology:9 An agnosia that is a deficiency in understanding, processing, or describing emotions.

Aliases & Classifications for Alexithymia

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9Disease Ontology, 11DISEASES
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Classifications:

Malacards categories (disease lists): (See all malacards categories)
Global: Fetal diseases


Aliases & Descriptions:

alexithymia 9 11


External Ids:

Disease Ontology9 DOID:0060131

Related Diseases for Alexithymia

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Sources:
18GeneCards, 19GeneDecks
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Diseases related to Alexithymia via text searches within MalaCards or GeneCards/GeneDecks gene sharing:

(show top 50)    (show all 147)
idRelated DiseaseScoreTop Affiliating Genes
1personality disorder30.8SLC6A4, DRD2, TTF2
2eating disorder30.8SLC6A4, COMT
3panic disorder30.6SLC6A4, TTF2, COMT
4alcohol dependence30.6ANKK1, DRD2, SLC6A4
5fibromyalgia30.6COMT, SLC6A4
6substance dependence30.5SLC6A4, DRD2, COMT
7asthma30.4IL4, CCL4, CCR5, TTF2, CCL3
8schizophrenia30.4SLC6A4, DRD2, COMT, TTF2
9obsessive-compulsive disorder30.3DRD2, COMT, TTF2, SLC6A4
10borderline personality disorder30.3SLC6A4, TTF2
11breast cancer30.3TTF2, CCL4, CCL3, COMT, DRD2, CCR5
12pathological gambling30.2DRD2
13migraine30.2SLC6A4, COMT, DRD2
14obesity30.2CRP, TTF2, COMT, DRD2, IL6
15mood disorder30.1COMT, SLC6A4, DRD2
16generalized anxiety disorder30.0SLC6A4
17myocardial infarction29.9CCL3, SLC6A4, CRP, COMT, CCR5
18cocaine dependence29.9DRD2, SLC6A4
19alcohol abuse29.9SLC6A4, DRD2, COMT
20attention deficit hyperactivity disorder29.9SLC6A4, DRD2, COMT
21antisocial personality disorder29.8ANKK1, TTF2, DRD2, SLC6A4
22systemic lupus erythematosus29.8IL4, CCL4, CRP, CCL3, CCR5, IL6
23multiple sclerosis29.8CCL4, IL4, IL6, COMT, CCR5, DRD2
24hypertension29.8SLC6A4, CRP
25anxiety disorder29.8SLC6A4, COMT, DRD2, TTF2
26psychotic disorder29.8COMT, SLC6A4, DRD2, TTF2
27inflammatory bowel disease29.7IL6, IL4, CCR5, CRP
28atherosclerosis29.7IL6, CCR5, CCL4, CRP, COMT
29rheumatoid arthritis29.6IL6, CRP, IL4, CCL4, CCL3, CCR5
30arthritis29.6CRP, TTF2, CCL3, CCR5, IL4, IL6
31parkinson's disease10.4
32somatoform disorder10.4
33brain injury10.3
34traumatic brain injury10.3
35major depressive disorder10.2
36anorexia nervosa10.2
37chronic pain10.2
38post-traumatic stress disorder10.1
39urticaria10.1
40back pain10.1
41aspergillosis10.1CCL3
42neuroleptic malignant syndrome10.1DRD2
43bronchiolitis10.1CCL3
44heroin dependence10.1DRD2, ANKK1
45dengue disease10.1CCL3, CCL4
46human immunodeficiency virus infectious disease10.1CCL3, CCL4
47lyme disease10.1CCL3, CCL4
48toxic shock syndrome10.1CCL3, CCL4
49bacteriuria10.1CRP
50aortic aneurysm10.1CRP

Graphical network of the top 20 diseases related to Alexithymia:



Diseases related to alexithymia

Symptoms for Alexithymia

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Drugs & Therapeutics for Alexithymia

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Sources:
6CenterWatch, 43NIH Clinical Center, 7ClinicalTrials
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Approved drugs:

Search CenterWatch for Alexithymia

Drug clinical trials:

Search ClinicalTrials for Alexithymia

Search NIH Clinical Center for Alexithymia

Search CenterWatch for Alexithymia

Genetic Tests for Alexithymia

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Anatomical Context for Alexithymia

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Sources:
34MalaCards
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MalaCards organs/tissues related to Alexithymia:

34
Brain, Breast, Testes, Heart, Cortex, Thyroid, Skin, Prefrontal cortex, Globus pallidus, Colon, Eye, Lung, Cingulate cortex

Animal Models for Alexithymia or affiliated genes

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Sources:
38MGI
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MGI Mouse Phenotypes related to Alexithymia:

38
idDescriptionMGI Source AccessionScoreTop Affiliating Genes
1MP:00053858.5DRD2, CRP, COMT, IL6, CCR5, SLC6A4
2MP:00053818.0CCL3, CCR5, IL4, IL6, DRD2
3MP:00053877.7CCR5, IL4, IL6, DRD2, CCL3, CRP
4MP:00036317.6SLC6A4, DRD2, COMT, IL6, IL4, CCR5
5MP:00053767.4IL4, CCR5, IL6, COMT, CRP, DRD2

Publications for Alexithymia

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Sources:
53PubMed
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Articles related to Alexithymia:

(show top 50)    (show all 503)
idTitleAuthorsYear
1
Distinct associations of insula and cingulate volume with the cognitive and affective dimensions of alexithymia. (24334109)
2013
2
Alexithymia and personality in relation to social anxiety among university students. (23246382)
2013
3
HPA system activity in alexithymia: a cortisol awakening response study. (23627992)
2013
4
I don't know how I feel, therefore I act: alexithymia, urgency, and alcohol problems. (23384454)
2013
5
The relationship between attachment styles and alexithymia: Mediating role of defense mechanisms. (24309875)
2013
6
Alexithymia, emotional empathy, and self-regulation in anorexia nervosa. (23638441)
2013
7
A family history of alcoholism relates to alexithymia in substance use disorder patients. (23642633)
2013
8
Brain response during visual emotional processing: an fMRI study of alexithymia. (23850105)
2013
9
Alexithymia, not autism, predicts poor recognition of emotional facial expressions. (23528789)
2013
10
Effects of childhood trauma on somatization in major depressive disorder: The role of alexithymia. (22884234)
2013
11
Alexithymia as a mediator between attachment and the development of borderline personality disorder in adolescence. (23013337)
2012
12
Alexithymia is associated with an augmenter profile, but not only: evidence for anticipation to arousing music. (22962856)
2012
13
Alexithymia in severe idiopathic scoliosis: findings from a cross-sectional study of adolescents who have or have not had operations. (22373771)
2012
14
Alexithymia and alcohol consumption: the mediating effects of drinking motives. (22154505)
2012
15
Alexithymia in healthy young men: a voxel-based morphometric study. (21723620)
2012
16
Alexithymia and dependent personality disorder. (22349651)
2012
17
Alexithymia is a non-motor symptom of Parkinson disease. (22273734)
2012
18
A naturalistic study of alexithymia among psychiatric outpatients treated in an integrated group therapy program. (22903919)
2012
19
Associations between facial emotion recognition, cognition and alexithymia in patients with schizophrenia: comparison of photographic and virtual reality presentations. (22954834)
2012
20
Child maltreatment, subsequent non-suicidal self-injury and the mediating roles of dissociation, alexithymia and self-blame. (22858062)
2012
21
Alexithymia in Chinese chronic obstructive pulmonary disease (COPD) patients: the prevalence and related factors of alexithymia. (22401970)
2012
22
Alexithymia is not a stable personality trait in patients with substance use disorders. (22382053)
2012
23
The relationship between alexithymia and maladaptive perfectionism in eating disorders: a mediation moderation analysis methodology. (22290034)
2011
24
Alexithymia, craving and attachment in a heavy drinking population. (21215527)
2011
25
Impact of childhood trauma, alexithymia, dissociation, and emotion suppression on emotional Stroop task. (21193101)
2011
26
Interaction effect of functional variants of the BDNF and DRD2/ANKK1 gene is associated with alexithymia in healthy human subjects. (21097659)
2011
27
Alexithymia in neurodegenerative disease. (21432723)
2011
28
Evaluation of alexithymia and depression in severe obese patients not affected by eating disorders. (21727778)
2011
29
Distress and alexithymia in lung recipients - psychosocial strains and associations with chronic allograft dysfunction. (20175005)
2010
30
Alexithymia and temperament and character model of personality in patients with major depressive disorder. (19932828)
2010
31
Commentary on the paper "Is alexithymia a risk factor for major depression, personality disorder, or alcohol use disorders? A prospective population-based study". (20159213)
2010
32
Disease outcome, alexithymia and depression are differently associated with serum IL-18 levels in acute stroke. (19534720)
2009
33
Alexithymia, temperament and character as predictors of psychopathology in patients with major depression. (19084277)
2009
34
Alexithymia and fear of pain independently predict heat pain intensity ratings among undergraduate university students. (19714270)
2009
35
Alexithymia, absorption, and cognitive failures in depersonalization disorder: a comparison to posttraumatic stress disorder and healthy volunteers. (19597356)
2009
36
Alexithymia and pathological gambling. (20155587)
2009
37
Alexithymia and therapist reactions to the patient: expression of positive emotion as a mediator. (18834276)
2008
38
Alexithymia and cognitive dysfunctions in patients with panic disorder. (18332616)
2008
39
Self-injurious behaviour, traumatic life events and alexithymia among treatment-seeking opiate addicts: prevalence, pattern and correlates. (18639391)
2008
40
Relationship between diary-keeping and tendencies toward alexithymia and rumination. (19320211)
2008
41
No words for feelings: alexithymia in schizophrenia patients and first-degree relatives. (17145278)
2007
42
Regulation of emotions during experimental stress in alexithymia. (17540222)
2007
43
Alexithymia, somatization and negative affect in a community sample. (17258817)
2007
44
Empathy and judging other's pain: an fMRI study of alexithymia. (17150987)
2007
45
Factors related to anxiety and depression in women with breast cancer and their husbands: role of alexithymia and family functioning. (17216201)
2007
46
Alexithymia in chronic fatigue syndrome: associations with momentary, recall, and retrospective measures of somatic complaints and emotions. (17244849)
2007
47
Alexithymia and interpersonal problems. (17016830)
2007
48
Response to "Letter to the Editor: The overlap between alexithymia and Asperger's syndrome", Fitzgerald and Bellgrove, Journal of Autism and Developmental Disorders, 36(4). (17080269)
2006
49
Alexithymia and PTSD symptoms in urban police officers: cross-sectional and prospective findings. (16788996)
2006
50
Predicting resistance to stress: incremental validity of trait emotional intelligence over alexithymia and optimism. (17295962)
2006

Variations for Alexithymia

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Expression for genes affiliated with Alexithymia

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Sources:
2BioGPS, 16Gene Expression Omnibus DataSets
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Expression patterns in normal tissues for genes affiliated with Alexithymia

Search GEO for disease gene expression data for Alexithymia.

Pathways for genes affiliated with Alexithymia

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Sources:
51PathCards, 39NCBI BioSystems Database, 55R&D Systems, 54QIAGEN, 31KEGG, 56Reactome, 61Thomson Reuters
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Pathways related to Alexithymia according to GeneCards/GeneDecks:

(show all 16)
idSuper pathways (with members indented)ScoreTop Affiliating Genes
19.7IL6, IL4
29.7IL6, IL4
39.7IL6, IL4
4
Show member pathways
9.4IL6, IL4, CCR5
5
Show member pathways
BCR signaling pathway39
TCR Signaling Pathway39
9.4CCR5, IL4, IL6
6
Show member pathways
9.0CCL4, CCL3
7
Show member pathways
8.7CCL3, CCR5, CCL4
8
Show member pathways
8.7CCL3, CCR5, CCL4
9
Show member pathways
8.6CCL3, CCL4, IL6
10
Show member pathways
Immune response IL 12 induced IFN gamma production61
8.4IL4, CCL4, CCR5, CCL3
11
Show member pathways
8.3CCL3, CCL4, IL4, IL6
12
Show member pathways
8.2DRD2, CCL4, CCR5, CCL3, WNT10A
13
Show member pathways
8.0CCL3, CCR5, CCL4, IL4, IL6
14
Show member pathways
8.0CCL3, CCR5, CCL4, IL4, IL6
15
Show member pathways
8.0CCL3, CCR5, CCL4, IL4, IL6
16
Show member pathways
8.0CCL3, CCR5, CCL4, IL4, IL6

Compounds for genes affiliated with Alexithymia

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Sources:
52PharmGKB, 46Novoseek, 12DrugBank, 25HMDB, 30IUPHAR, 62Tocris Bioscience
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Compounds related to Alexithymia according to GeneCards/GeneDecks:

(show top 50)    (show all 118)
idCompoundScoreTop Affiliating Genes
1antipsychotics5210.0COMT, DRD2, ANKK1
2methylphenidate46 52 1211.9SLC6A4, DRD2, COMT
3maoa469.9COMT, DRD2, SLC6A4
4methadone52 46 1211.8DRD2, CCR5, ANKK1, TTF2
5heroin46 52 1211.8COMT, DRD2, SLC6A4
6bupropion52 46 25 1212.8ANKK1, COMT, DRD2, SLC6A4
7risperidone46 52 30 62 25 1214.8COMT, DRD2, ANKK1, SLC6A4
8olanzapine46 52 30 25 1213.8DRD2, COMT, SLC6A4, ANKK1
9ketamine46 30 1211.7SLC6A4, DRD2, CRP
10nicotine46 30 52 1212.5ANKK1, COMT, TTF2, DRD2, SLC6A4
11okt3469.5CRP, IL6, IL4
12amphotericin b469.4CCL4, CRP, IL4
13clozapine46 30 52 1212.4SLC6A4, CRP, COMT, DRD2, ANKK1
14morphine46 52 30 1212.3DRD2, CCL4, CCR5, COMT
15isopentenyl diphosphate46 3010.1CCL4, CCR5, CCL3
16norepinephrine46 25 1211.1IL6, COMT, SLC6A4, CRP, DRD2
17pmma469.1CRP, IL6, CCL3
18methacholine46 52 1211.1IL4, TTF2, CCL3, CRP
19mdms469.1CCL3, CCR5, CCL4
20larc469.1CCR5, CCL3, CCL4
21methylcellulose469.0IL6, IL4, CCL3, CCR5
22anaphylatoxin469.0IL6, IL4, CCL3
23mcp 1469.0CCL3, CCL4, IL6
24neopterin468.9CRP, IL6, IL4, CCL3
25cocaine46 129.9CCR5, COMT, DRD2, CCL3, SLC6A4
26gm-csf46 309.9CCL3, IL6, IL4
27polyinosinic-polycytidylic acid468.9IL6, CCL3, IL4
28ivig468.9CCR5, CCL4, IL4, IL6, CRP
29ritonavir46 52 1210.8CCL3, IL4, CCL4, CCR5
30tarc468.8CCR5, CCL3, CCL4, IL4
31groalpha468.8CCL4, IL6, CCR5, CCL3
32ccl346 309.7CCR5, CCL4, CCL3, IL6
33epinephrine46 25 1210.7DRD2, COMT, SLC6A4, CCL3, IL6
348-isoprostane468.6CRP, IL6, CCL3
35triptolide468.5IL6, CCL4, CCL3
36prednisolone46 30 1210.5IL6, CCL4, CCL3, CRP
37mip 1alpha468.4CCL4, CCR5, IL4, IL6, CCL3
38il 10468.4CCL3, CCR5, CCL4, IL4, IL6
39rantes468.4CCL3, IL4, CCL4, IL6, CCR5
40endotoxin468.3CRP, IL6, CCL4, CCL3
41histamine46 30 2510.3CCL3, IL4, CCR5, IL6, CCL4
42sb 20358046 629.3IL6, CCL3, CCL4, IL4, CRP
43pge2468.2CCL4, IL4, CCL3, CCR5, IL6
44cyclosporin a46 30 6210.2IL4, CCL4, CCR5, CCL3, TTF2, IL6
45cholesterol46 30 25 1211.0CRP, CCL3, CCR5, IL6, CCL4, TTF2
46dexamethasone46 52 30 1211.0CCR5, IL6, IL4, CCL4, CCL3, TTF2
47cysteine467.9COMT, CCR5, TTF2, SLC6A4, CCL4, CCL3
48alanine467.8TTF2, CCL3, CCR5, CCL4, IL6, CRP
49vegf467.8CCL3, CCL4, IL4, IL6, TTF2, CRP
50simvastatin46 52 62 30 25 1212.7CCR5, CCL4, SLC6A4, IL6, CRP, CCL3

GO Terms for genes affiliated with Alexithymia

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Sources:
17Gene Ontology
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Cellular components related to Alexithymia according to GeneCards/GeneDecks:

idNameGO IDScoreTop Affiliating Genes
1external side of plasma membraneGO:0098979.4IL6, IL4, CCR5
2extracellular spaceGO:0056157.4CRP, IL6, IL4, CCL4, CCL3, WNT10A

Biological processes related to Alexithymia according to GeneCards/GeneDecks:

(show all 20)
idNameGO IDScoreTop Affiliating Genes
1negative regulation of lipid storageGO:01088810.0CRP, IL6
2defense response to protozoanGO:0428329.9IL4, IL6
3signalingGO:0230529.7CCR5, CCL3
4release of sequestered calcium ion into cytosol by sarcoplasmic reticulumGO:0148089.7CCL3, CCR5
5response to cholesterolGO:0707239.6CCR5, CCL3
6response to hypoxiaGO:0016669.6CRP, DRD2, SLC6A4
7defense response to Gram-positive bacteriumGO:0508309.4CRP, IL6
8monocyte chemotaxisGO:0025489.4IL6, CCL3
9negative regulation of osteoclast differentiationGO:0456719.4IL4, CCL3
10positive regulation of natural killer cell chemotaxisGO:20005039.3CCL4, CCL3
11negative regulation by host of viral transcriptionGO:0439229.3CCL4, CCL3
12positive regulation of gene expressionGO:0106289.3SLC6A4, CCL3, WNT10A
13chemotaxisGO:0069359.2IL4, CCR5, CCL3
14positive regulation of ERK1 and ERK2 cascadeGO:0703749.2CCL3, IL6, DRD2
15response to drugGO:0424939.2IL4, IL6, COMT, DRD2, SLC6A4
16positive regulation of calcium-mediated signalingGO:0508509.0CCL4, CCL3
17positive regulation of calcium ion transportGO:0519288.9CCL3, CCL4
18cell-cell signalingGO:0072678.7CCL4, CCR5, CCL3
19response to toxic substanceGO:0096368.7SLC6A4, DRD2, CCL4, CCL3
20inflammatory responseGO:0069548.3CCL3, CCR5, CCL4, IL6, CRP

Molecular functions related to Alexithymia according to GeneCards/GeneDecks:

idNameGO IDScoreTop Affiliating Genes
1cytokine activityGO:0051259.1IL6, IL4, CCL4
2CCR1 chemokine receptor bindingGO:0317269.0CCL4, CCL3
3CCR5 chemokine receptor bindingGO:0317308.9CCL4, CCL3
4protein bindingGO:0055155.9AVEN, TTF2, CCL3, CCR5, CCL4, IL4

Products for genes affiliated with Alexithymia

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  • Antibodies
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Sources for Alexithymia

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4CDC
14ExPASy
15FMA
23GTR
24HGMD
25HMDB
26ICD10
27ICD10 via Orphanet
28ICD9CM
30IUPHAR
31KEGG
36MeSH
37MESH via Orphanet
38MGI
41NCIt
42NDF-RT
45NINDS
46Novoseek
48OMIM
49OMIM via Orphanet
53PubMed
54QIAGEN
60SNOMED-CT via Orphanet
63UMLS
64UMLS via Orphanet