MCID: ALX002
MIFTS: 51

Alexithymia malady

Fetal diseases category
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Summaries for Alexithymia

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Wikipedia:65 Alexithymia /?e?l?ks???a?mi?/ is a personality construct characterized by the sub-clinical inability to... more...

MalaCards based summary: Alexithymia is related to eating disorder and personality disorder. An important gene associated with Alexithymia is ANKK1 (ankyrin repeat and kinase domain containing 1), and among its related pathways are Cytokines and Inflammatory Response and IL-9 Signaling and its Primary Biological Effects in Different Immune Cell Types. The compounds antipsychotics and methylphenidate have been mentioned in the context of this disorder. Affiliated tissues include brain, testes and breast, and related mouse phenotypes are cardiovascular system and digestive/alimentary.

Disease Ontology:8 An agnosia that is a deficiency in understanding, processing, or describing emotions.

Aliases & Classifications for Alexithymia

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Alexithymia, Aliases & Descriptions:

Name: Alexithymia 8 10


Classifications:

Malacards categories (disease lists): (See all malacards categories)
Global: Fetal diseases


External Ids:

Disease Ontology8 DOID:0060131

Related Diseases for Alexithymia

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Diseases related to Alexithymia via text searches within MalaCards or GeneCards/GeneDecks gene sharing:

(show top 50)    (show all 149)
idRelated DiseaseScoreTop Affiliating Genes
1eating disorder31.0SLC6A4, COMT
2personality disorder30.9SLC6A4, DRD2, TTF2
3fibromyalgia30.8COMT, SLC6A4
4panic disorder30.8SLC6A4, TTF2, COMT
5pathological gambling30.7DRD2
6alcohol dependence30.7ANKK1, DRD2, SLC6A4
7borderline personality disorder30.6SLC6A4, TTF2
8substance dependence30.6SLC6A4, DRD2, COMT
9generalized anxiety disorder30.5SLC6A4
10obsessive-compulsive disorder30.3DRD2, COMT, TTF2, SLC6A4
11schizophrenia30.3SLC6A4, DRD2, COMT, TTF2
12migraine30.3SLC6A4, COMT, DRD2
13asthma30.2IL4, CCL4, CCR5, TTF2, CCL3
14chronic obstructive pulmonary disease30.2CRP, IL6
15mood disorder30.2COMT, SLC6A4, DRD2
16cocaine dependence30.1DRD2, SLC6A4
17alcohol abuse30.0SLC6A4, DRD2, COMT
18attention deficit hyperactivity disorder30.0SLC6A4, DRD2, COMT
19breast cancer29.9TTF2, CCL4, CCL3, COMT, DRD2, CCR5
20antisocial personality disorder29.9ANKK1, TTF2, DRD2, SLC6A4
21hypertension29.9SLC6A4, CRP
22obesity29.8CRP, TTF2, COMT, DRD2, IL6
23anxiety disorder29.8SLC6A4, COMT, DRD2, TTF2
24psychotic disorder29.8COMT, SLC6A4, DRD2, TTF2
25myocardial infarction29.5CCL3, SLC6A4, CRP, COMT, CCR5
26inflammatory bowel disease29.3IL6, IL4, CCR5, CRP
27multiple sclerosis29.3CCL4, IL4, IL6, COMT, CCR5, DRD2
28atherosclerosis29.3IL6, CCR5, CCL4, CRP, COMT
29systemic lupus erythematosus29.2IL4, CCL4, CRP, CCL3, CCR5, IL6
30rheumatoid arthritis28.9IL6, CRP, IL4, CCL4, CCL3, CCR5
31arthritis28.8CRP, TTF2, CCL3, CCR5, IL4, IL6
32aspergillosis10.5CCL3
33neuroleptic malignant syndrome10.4DRD2
34parkinson's disease10.4
35bronchiolitis10.4CCL3
36somatoform disorder10.4
37brain injury10.4
38traumatic brain injury10.4
39heroin dependence10.4DRD2, ANKK1
40dengue disease10.3CCL3, CCL4
41human immunodeficiency virus infectious disease10.3CCL3, CCL4
42lyme disease10.3CCL3, CCL4
43toxic shock syndrome10.3CCL3, CCL4
44bacteriuria10.3CRP
45aortic aneurysm10.3CRP
46bulimia nervosa10.2COMT, SLC6A4
47pulmonary eosinophilia10.2CCL3, IL4
48cocaine abuse10.2DRD2, SLC6A4
49drug dependence10.2DRD2, SLC6A4
50pulmonary sarcoidosis10.2CCL3, CCR5

Graphical network of the top 20 diseases related to Alexithymia:



Diseases related to alexithymia

Symptoms for Alexithymia

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Drugs & Therapeutics for Alexithymia

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Drug clinical trials:

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Search NIH Clinical Center for Alexithymia

Genetic Tests for Alexithymia

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Anatomical Context for Alexithymia

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MalaCards organs/tissues related to Alexithymia:

32
Brain, Testes, Breast, Cortex, Heart, Thyroid, Eye, Colon, Lung, Skin, Prefrontal cortex, Cingulate cortex, Globus pallidus, Subthalamic nucleus, Pituitary

Animal Models for Alexithymia or affiliated genes

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MGI Mouse Phenotypes related to Alexithymia:

36
idDescriptionMGI Source AccessionScoreTop Affiliating Genes
1MP:00053858.5SLC6A4, DRD2, CRP, COMT, IL6, CCR5
2MP:00053818.0CCL3, CCR5, IL4, IL6, DRD2
3MP:00053877.7CCL3, CCR5, IL4, IL6, COMT, CRP
4MP:00036317.6CCL3, CCR5, IL4, IL6, COMT, DRD2
5MP:00053767.4SLC6A4, CCL3, CCR5, IL4, IL6, COMT

Publications for Alexithymia

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Articles related to Alexithymia:

(show top 50)    (show all 527)
idTitleAuthorsYear
1
Facial and Bodily Emotion Recognition in Multiple Sclerosis: The Role of Alexithymia and Other Characteristics of the Disease. (25373767)
2014
2
Caffeine use and alexithymia in university students. (25188705)
2014
3
Alexithymia impact on type 1 and type 2 diabetes: a case-control study. (25148784)
2014
4
Distinct associations of insula and cingulate volume with the cognitive and affective dimensions of alexithymia. (24334109)
2013
5
Alexithymia and personality in relation to social anxiety among university students. (23246382)
2013
6
HPA system activity in alexithymia: a cortisol awakening response study. (23627992)
2013
7
I don't know how I feel, therefore I act: alexithymia, urgency, and alcohol problems. (23384454)
2013
8
Stress coping strategies in patients with psychogenic non-epileptic seizures and how they relate to trauma symptoms, alexithymia, anger and mood. (23689067)
2013
9
The relationship between attachment styles and alexithymia: Mediating role of defense mechanisms. (24309875)
2013
10
Alexithymia, emotional empathy, and self-regulation in anorexia nervosa. (23638441)
2013
11
A family history of alcoholism relates to alexithymia in substance use disorder patients. (23642633)
2013
12
Brain response during visual emotional processing: an fMRI study of alexithymia. (23850105)
2013
13
Alexithymia, not autism, predicts poor recognition of emotional facial expressions. (23528789)
2013
14
Effects of childhood trauma on somatization in major depressive disorder: The role of alexithymia. (22884234)
2013
15
Alexithymia as a mediator between attachment and the development of borderline personality disorder in adolescence. (23013337)
2012
16
Alexithymia is associated with an augmenter profile, but not only: evidence for anticipation to arousing music. (22962856)
2012
17
Alexithymia in severe idiopathic scoliosis: findings from a cross-sectional study of adolescents who have or have not had operations. (22373771)
2012
18
Alexithymia and alcohol consumption: the mediating effects of drinking motives. (22154505)
2012
19
Alexithymia in healthy young men: a voxel-based morphometric study. (21723620)
2012
20
Alexithymia and dependent personality disorder. (22349651)
2012
21
Alexithymia is a non-motor symptom of Parkinson disease. (22273734)
2012
22
Associations between facial emotion recognition, cognition and alexithymia in patients with schizophrenia: comparison of photographic and virtual reality presentations. (22954834)
2012
23
Child maltreatment, subsequent non-suicidal self-injury and the mediating roles of dissociation, alexithymia and self-blame. (22858062)
2012
24
Alexithymia in Chinese chronic obstructive pulmonary disease (COPD) patients: the prevalence and related factors of alexithymia. (22401970)
2012
25
The relationship between alexithymia and maladaptive perfectionism in eating disorders: a mediation moderation analysis methodology. (22290034)
2011
26
Alexithymia, craving and attachment in a heavy drinking population. (21215527)
2011
27
Impact of childhood trauma, alexithymia, dissociation, and emotion suppression on emotional Stroop task. (21193101)
2011
28
Interaction effect of functional variants of the BDNF and DRD2/ANKK1 gene is associated with alexithymia in healthy human subjects. (21097659)
2011
29
Alexithymia in neurodegenerative disease. (21432723)
2011
30
Distress and alexithymia in lung recipients - psychosocial strains and associations with chronic allograft dysfunction. (20175005)
2010
31
Alexithymia and temperament and character model of personality in patients with major depressive disorder. (19932828)
2010
32
Commentary on the paper "Is alexithymia a risk factor for major depression, personality disorder, or alcohol use disorders? A prospective population-based study". (20159213)
2010
33
Disease outcome, alexithymia and depression are differently associated with serum IL-18 levels in acute stroke. (19534720)
2009
34
Alexithymia, temperament and character as predictors of psychopathology in patients with major depression. (19084277)
2009
35
Alexithymia and fear of pain independently predict heat pain intensity ratings among undergraduate university students. (19714270)
2009
36
Alexithymia, absorption, and cognitive failures in depersonalization disorder: a comparison to posttraumatic stress disorder and healthy volunteers. (19597356)
2009
37
Alexithymia and pathological gambling. (20155587)
2009
38
Alexithymia and therapist reactions to the patient: expression of positive emotion as a mediator. (18834276)
2008
39
Alexithymia and cognitive dysfunctions in patients with panic disorder. (18332616)
2008
40
Self-injurious behaviour, traumatic life events and alexithymia among treatment-seeking opiate addicts: prevalence, pattern and correlates. (18639391)
2008
41
Relationship between diary-keeping and tendencies toward alexithymia and rumination. (19320211)
2008
42
No words for feelings: alexithymia in schizophrenia patients and first-degree relatives. (17145278)
2007
43
Regulation of emotions during experimental stress in alexithymia. (17540222)
2007
44
Alexithymia, somatization and negative affect in a community sample. (17258817)
2007
45
Empathy and judging other's pain: an fMRI study of alexithymia. (17150987)
2007
46
Factors related to anxiety and depression in women with breast cancer and their husbands: role of alexithymia and family functioning. (17216201)
2007
47
Alexithymia in chronic fatigue syndrome: associations with momentary, recall, and retrospective measures of somatic complaints and emotions. (17244849)
2007
48
Response to "Letter to the Editor: The overlap between alexithymia and Asperger's syndrome", Fitzgerald and Bellgrove, Journal of Autism and Developmental Disorders, 36(4). (17080269)
2006
49
Alexithymia and PTSD symptoms in urban police officers: cross-sectional and prospective findings. (16788996)
2006
50
Predicting resistance to stress: incremental validity of trait emotional intelligence over alexithymia and optimism. (17295962)
2006

Variations for Alexithymia

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Expression for genes affiliated with Alexithymia

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Expression patterns in normal tissues for genes affiliated with Alexithymia

Search GEO for disease gene expression data for Alexithymia.

Pathways for genes affiliated with Alexithymia

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Pathways related to Alexithymia according to GeneCards/GeneDecks:

(show all 16)
idSuper pathways (with members indented)ScoreTop Affiliating Genes
19.7IL6, IL4
29.7IL6, IL4
39.7IL6, IL4
4
Show member pathways
9.4IL6, IL4, CCR5
5
Show member pathways
BCR signaling pathway37
TCR Signaling Pathway37
9.4CCR5, IL4, IL6
6
Show member pathways
9.0CCL4, CCL3
7
Show member pathways
8.7CCL3, CCR5, CCL4
8
Show member pathways
8.7CCL3, CCR5, CCL4
9
Show member pathways
8.6CCL3, CCL4, IL6
10
Show member pathways
Immune response IL 12 induced IFN gamma production60
8.4IL4, CCL4, CCR5, CCL3
11
Show member pathways
8.3CCL3, CCL4, IL4, IL6
12
Show member pathways
8.2DRD2, CCL4, CCR5, CCL3, WNT10A
13
Show member pathways
8.0CCL3, CCR5, CCL4, IL4, IL6
14
Show member pathways
8.0CCL3, CCR5, CCL4, IL4, IL6
15
Show member pathways
8.0CCL3, CCR5, CCL4, IL4, IL6
16
Show member pathways
8.0CCL3, CCR5, CCL4, IL4, IL6

Compounds for genes affiliated with Alexithymia

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Compounds related to Alexithymia according to GeneCards/GeneDecks:

(show top 50)    (show all 118)
idCompoundScoreTop Affiliating Genes
1antipsychotics5010.0COMT, DRD2, ANKK1
2methylphenidate44 50 1111.9SLC6A4, DRD2, COMT
3maoa449.9COMT, DRD2, SLC6A4
4methadone50 44 1111.8DRD2, CCR5, ANKK1, TTF2
5heroin44 50 1111.8COMT, DRD2, SLC6A4
6bupropion50 44 24 1112.8ANKK1, COMT, DRD2, SLC6A4
7risperidone44 50 28 61 24 1114.8COMT, DRD2, ANKK1, SLC6A4
8olanzapine44 50 28 24 1113.8DRD2, COMT, SLC6A4, ANKK1
9ketamine44 28 1111.7SLC6A4, DRD2, CRP
10nicotine44 28 50 1112.5ANKK1, COMT, TTF2, DRD2, SLC6A4
11okt3449.5CRP, IL6, IL4
12amphotericin b449.4CCL4, CRP, IL4
13clozapine44 28 50 1112.4SLC6A4, CRP, COMT, DRD2, ANKK1
14morphine44 50 28 1112.3DRD2, CCL4, CCR5, COMT
15isopentenyl diphosphate44 2810.1CCL4, CCR5, CCL3
16norepinephrine44 24 1111.1IL6, COMT, SLC6A4, CRP, DRD2
17pmma449.1CRP, IL6, CCL3
18methacholine44 50 1111.1IL4, TTF2, CCL3, CRP
19mdms449.1CCL3, CCR5, CCL4
20larc449.1CCR5, CCL3, CCL4
21methylcellulose449.0IL6, IL4, CCL3, CCR5
22anaphylatoxin449.0IL6, IL4, CCL3
23mcp 1449.0CCL3, CCL4, IL6
24neopterin448.9CRP, IL6, IL4, CCL3
25cocaine44 119.9CCR5, COMT, DRD2, CCL3, SLC6A4
26gm-csf44 289.9CCL3, IL6, IL4
27polyinosinic-polycytidylic acid448.9IL6, CCL3, IL4
28ivig448.9CCR5, CCL4, IL4, IL6, CRP
29ritonavir44 50 1110.8CCL3, IL4, CCL4, CCR5
30tarc448.8CCR5, CCL3, CCL4, IL4
31groalpha448.8CCL4, IL6, CCR5, CCL3
32ccl344 289.7CCR5, CCL4, CCL3, IL6
33epinephrine44 24 1110.7DRD2, COMT, SLC6A4, CCL3, IL6
348-isoprostane448.6CRP, IL6, CCL3
35triptolide448.5IL6, CCL4, CCL3
36prednisolone44 28 1110.5IL6, CCL4, CCL3, CRP
37mip 1alpha448.4CCL4, CCR5, IL4, IL6, CCL3
38il 10448.4CCL3, CCR5, CCL4, IL4, IL6
39rantes448.4CCL3, IL4, CCL4, IL6, CCR5
40endotoxin448.3CRP, IL6, CCL4, CCL3
41histamine44 28 2410.3CCL3, IL4, CCR5, IL6, CCL4
42sb 20358044 619.3IL6, CCL3, CCL4, IL4, CRP
43pge2448.2CCL4, IL4, CCL3, CCR5, IL6
44cyclosporin a44 28 6110.2IL4, CCL4, CCR5, CCL3, TTF2, IL6
45cholesterol44 28 24 1111.0CRP, CCL3, CCR5, IL6, CCL4, TTF2
46dexamethasone44 50 28 1111.0CCR5, IL6, IL4, CCL4, CCL3, TTF2
47cysteine447.9COMT, CCR5, TTF2, SLC6A4, CCL4, CCL3
48alanine447.8TTF2, CCL3, CCR5, CCL4, IL6, CRP
49vegf447.8CCL3, CCL4, IL4, IL6, TTF2, CRP
50simvastatin44 50 61 28 24 1112.7CCR5, CCL4, SLC6A4, IL6, CRP, CCL3

GO Terms for genes affiliated with Alexithymia

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Cellular components related to Alexithymia according to GeneCards/GeneDecks:

idNameGO IDScoreTop Affiliating Genes
1external side of plasma membraneGO:0098979.4IL6, IL4, CCR5
2extracellular spaceGO:0056157.4CRP, IL6, IL4, CCL4, CCL3, WNT10A

Biological processes related to Alexithymia according to GeneCards/GeneDecks:

(show all 20)
idNameGO IDScoreTop Affiliating Genes
1negative regulation of lipid storageGO:01088810.0CRP, IL6
2defense response to protozoanGO:0428329.9IL4, IL6
3signalingGO:0230529.7CCR5, CCL3
4release of sequestered calcium ion into cytosol by sarcoplasmic reticulumGO:0148089.7CCL3, CCR5
5response to cholesterolGO:0707239.6CCR5, CCL3
6response to hypoxiaGO:0016669.6CRP, DRD2, SLC6A4
7defense response to Gram-positive bacteriumGO:0508309.4CRP, IL6
8monocyte chemotaxisGO:0025489.4IL6, CCL3
9negative regulation of osteoclast differentiationGO:0456719.4IL4, CCL3
10positive regulation of natural killer cell chemotaxisGO:20005039.3CCL4, CCL3
11negative regulation by host of viral transcriptionGO:0439229.3CCL4, CCL3
12positive regulation of gene expressionGO:0106289.3SLC6A4, CCL3, WNT10A
13chemotaxisGO:0069359.2IL4, CCR5, CCL3
14positive regulation of ERK1 and ERK2 cascadeGO:0703749.2CCL3, IL6, DRD2
15response to drugGO:0424939.2IL4, IL6, COMT, DRD2, SLC6A4
16positive regulation of calcium-mediated signalingGO:0508509.0CCL4, CCL3
17positive regulation of calcium ion transportGO:0519288.9CCL3, CCL4
18cell-cell signalingGO:0072678.7CCL4, CCR5, CCL3
19response to toxic substanceGO:0096368.7SLC6A4, DRD2, CCL4, CCL3
20inflammatory responseGO:0069548.3CCL3, CCR5, CCL4, IL6, CRP

Molecular functions related to Alexithymia according to GeneCards/GeneDecks:

idNameGO IDScoreTop Affiliating Genes
1cytokine activityGO:0051259.1CCL4, IL4, IL6
2CCR5 chemokine receptor bindingGO:0317309.0CCL3, CCL4
3CCR1 chemokine receptor bindingGO:0317268.9CCL3, CCL4
4protein bindingGO:0055155.9AVEN, TTF2, CCL3, CCR5, CCL4, IL4

Products for genes affiliated with Alexithymia

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Sources for Alexithymia

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3CDC
13ExPASy
14FMA
22GTR
23HGMD
24HMDB
25ICD10
26ICD10 via Orphanet
27ICD9CM
28IUPHAR
29KEGG
34MeSH
35MESH via Orphanet
36MGI
39NCIt
40NDF-RT
43NINDS
44Novoseek
46OMIM
47OMIM via Orphanet
51PubMed
52QIAGEN
58SNOMED-CT via Orphanet
62UMLS
63UMLS via Orphanet