Aliases & Classifications for Alexithymia

MalaCards integrated aliases for Alexithymia:

Name: Alexithymia 12 14

Classifications:



External Ids:

Disease Ontology 12 DOID:0060131

Summaries for Alexithymia

Disease Ontology : 12 An agnosia that is a deficiency in understanding, processing, or describing emotions.

MalaCards based summary : Alexithymia is related to traumatic brain injury and anxiety. An important gene associated with Alexithymia is ANKK1 (Ankyrin Repeat And Kinase Domain Containing 1), and among its related pathways/superpathways are cAMP signaling pathway and Selective Serotonin Reuptake Inhibitor Pathway, Pharmacodynamics. The drugs Sertraline and Antidepressive Agents have been mentioned in the context of this disorder. Affiliated tissues include brain, testes and breast, and related phenotype is endocrine/exocrine gland.

Wikipedia : 72 Alexithymia /ˌeɪlɛksəˈθaɪmiə/ is a personality construct characterized by the subclinical inability to... more...

Related Diseases for Alexithymia

Diseases related to Alexithymia via text searches within MalaCards or GeneCards Suite gene sharing:

(show top 50) (show all 166)
# Related Disease Score Top Affiliating Genes
1 traumatic brain injury 30.5 COMT DRD2
2 anxiety 30.5 COMT HTR1A SLC6A4
3 somatoform disorder 30.5 COMT IL4
4 brain injury 30.4 COMT DRD2
5 alcohol use disorder 30.3 DRD2 SLC6A4
6 pathological gambling 30.2 DRD2 SLC6A4
7 eating disorder 30.0 COMT DRD2 OXTR SLC6A4
8 panic disorder 30.0 COMT HTR1A SLC6A4
9 personality disorder 29.9 COMT DRD2 HTR1A SLC6A4
10 borderline personality disorder 29.9 COMT HTR1A SLC6A4
11 paranoid schizophrenia 29.8 COMT SLC6A4
12 impulse control disorder 29.8 ANKK1 DRD2
13 substance abuse 29.6 COMT DRD2 SLC6A4
14 dyspepsia 29.6 HTR1A SLC6A4
15 obsessive-compulsive disorder 29.6 COMT DRD2 HTR1A SLC6A4
16 cocaine dependence 29.5 DRD2 SLC6A4
17 alcohol abuse 29.5 ANKK1 DRD2 SLC6A4
18 generalized anxiety disorder 29.5 DRD2 HTR1A SLC6A4
19 migraine with or without aura 1 29.4 COMT DRD2 HTR1A SLC6A4
20 bulimia nervosa 1 29.4 COMT SLC6A4
21 autism spectrum disorder 29.3 COMT DRD2 OXTR SLC6A4
22 premature ejaculation 29.3 COMT HTR1A SLC6A4
23 chronic fatigue syndrome 29.3 COMT HTR1A SLC6A4
24 migraine without aura 29.3 DRD2 HTR1A SLC6A4
25 alcohol dependence 29.2 ANKK1 COMT DRD2 HTR1A SLC6A4
26 antisocial personality disorder 29.2 ANKK1 COMT DRD2 SLC6A4
27 mood disorder 29.2 COMT DRD2 HTR1A SLC6A4
28 autism 29.2 COMT DRD2 HTR1A OXTR SLC6A4
29 post-traumatic stress disorder 29.1 COMT CRP DRD2 SLC6A4
30 psychotic disorder 28.9 COMT DRD2 HTR1A SLC6A4
31 major depressive disorder 28.9 COMT DRD2 HTR1A OXTR SLC6A4
32 parkinson disease, late-onset 28.9 COMT DRD2 HTR1A SLC6A4
33 bipolar disorder 28.9 COMT DRD2 HTR1A SLC6A4
34 disease of mental health 28.7 COMT DRD2 HTR1A OXTR SLC6A4
35 attention deficit-hyperactivity disorder 28.5 ANKK1 COMT DRD2 HTR1A SLC6A4
36 social emotional agnosia 11.0
37 alcohol-induced mental disorder 10.4 DRD2 SLC6A4
38 schizophreniform disorder 10.4 COMT DRD2
39 alcoholic psychosis 10.4 DRD2 SLC6A4
40 polysubstance abuse 10.4 COMT DRD2
41 social phobia 10.4 DRD2 SLC6A4
42 tardive dyskinesia 10.4 COMT DRD2
43 bruxism 10.4 DRD2 SLC6A4
44 microscopic colitis 10.4 IL4 SLC6A4
45 opioid addiction 10.3 COMT DRD2
46 opiate dependence 10.3 DRD2 SLC6A4
47 cocaine abuse 10.3 DRD2 SLC6A4
48 taqi polymorphism 10.3 ANKK1 DRD2
49 heroin dependence 10.3 ANKK1 DRD2
50 episodic pain syndrome, familial, 1 10.3

Graphical network of the top 20 diseases related to Alexithymia:



Diseases related to Alexithymia

Symptoms & Phenotypes for Alexithymia

MGI Mouse Phenotypes related to Alexithymia:

43
# Description MGI Source Accession Score Top Affiliating Genes
1 endocrine/exocrine gland MP:0005379 9.1 ABCB4 COMT DRD2 IL4 OXTR SLC6A4

Drugs & Therapeutics for Alexithymia

Drugs for Alexithymia (from DrugBank, HMDB, Dgidb, PharmGKB, IUPHAR, NovoSeek, BitterDB):

(show all 40)
# Name Status Phase Clinical Trials Cas Number PubChem Id
1
Sertraline Approved Phase 4 79617-96-2 68617
2 Antidepressive Agents Phase 4
3 Neurotransmitter Agents Phase 4,Phase 2
4 Neurotransmitter Uptake Inhibitors Phase 4,Phase 2
5 Psychotropic Drugs Phase 4,Phase 2
6
Serotonin Phase 4,Phase 2 50-67-9 5202
7 Serotonin Agents Phase 4,Phase 2
8 Serotonin Uptake Inhibitors Phase 4
9
Zopiclone Approved Phase 2 43200-80-2 5735
10
Oxytocin Approved, Vet_approved Phase 2 50-56-6 53477758 439302
11
3,4-Methylenedioxyamphetamine Experimental, Illicit Phase 2 4764-17-4 1614
12 Adrenergic Agents Phase 2
13 Hallucinogens Phase 2
14 N-Methyl-3,4-methylenedioxyamphetamine Phase 2
15 Central Nervous System Depressants Phase 2
16 Hypnotics and Sedatives Phase 2
17 Oxytocics Phase 2
18
Acetylcysteine Approved, Investigational Phase 1 616-91-1 12035
19 Antidotes Phase 1
20 Anti-Infective Agents Phase 1
21 Antioxidants Phase 1
22 Antiviral Agents Phase 1
23 Expectorants Phase 1
24 N-monoacetylcystine Phase 1
25 Protective Agents Phase 1
26 Respiratory System Agents Phase 1
27 Vitamins Phase 1
28
Hydrocortisone Approved, Vet_approved 50-23-7 657311 5754
29
Dopamine Approved 51-61-6, 62-31-7 681
30
Norepinephrine Approved 51-41-2 439260
31
Cocaine Approved, Illicit 50-36-2 446220 5760
32 Anti-Inflammatory Agents
33 Cortisol succinate
34 Hydrocortisone 17-butyrate 21-propionate
35 Hydrocortisone acetate
36 Analgesics
37 Dopamine Agents
38 Duloxetine Hydrochloride
39 Peripheral Nervous System Agents
40 Serotonin and Noradrenaline Reuptake Inhibitors

Interventional clinical trials:

(show all 36)

# Name Status NCT ID Phase Drugs
1 Clinical Assessment and Psychosocial Impact of Psoriasis Completed NCT01964443 Phase 4
2 Cognitive Behavioral Therapy Versus Sertraline in the Treatment of Post-Traumatic Stress Disorder Completed NCT00391430 Phase 4 Sertraline
3 Pain and Stress Management for Fibromyalgia Completed NCT01287481 Phase 2
4 MDMA-assisted Therapy for Social Anxiety in Autistic Adults Completed NCT02008396 Phase 2 Placebo;MDMA
5 Effectiveness of BBT-I and Zopiclone for Chronic Insomnia Completed NCT03339583 Phase 2 Zopiclone
6 Ocytocine and Cerebral Activation in Relation With Attachement Recruiting NCT02847143 Phase 2 nasal oxytocin or placebo
7 Autism Oxytocin Brain Project Recruiting NCT03033784 Phase 2 Oxytocin;Oxytocin;Oxytocin;Placebo
8 Early Study of N-Acetylcysteine to Treat Deliberate Self-Harm in Adolescents Completed NCT01111734 Phase 1 fMRI
9 Neurobiological, Neuropsychological,Linguistic and Gestural Processes and Phenomena in Individuals With Alexithymia Unknown status NCT00830752
10 Psychological Impact in Diabetes: Intervention With Affect School and Basal Body Awareness Unknown status NCT01498614
11 Psychopathological Risk Factors Associated With Conversion From Mild Cognitive Impairment to Dementia Unknown status NCT01436552
12 Halifax Treatment Refractory Depression Trial Unknown status NCT01141426
13 The Emotion Builder: An Intervention for Emotional Deficits After Brain Injury Completed NCT02432300
14 Online Treatment of Trichotillomania Completed NCT02044237
15 Outcomes of Mentalization-Based Treatment for Borderline Personality Disorder Completed NCT03295838
16 Moderating Impact of Various Emotion Personality Factors on Salivary Cortisol Response to a TSST Completed NCT00451126
17 Effectiveness of Standard Emergency Department Psychiatric Treatment Associated With Treatment Delivery by a Suicide Prevention Center Completed NCT00641498
18 Attention Bias Modification Treatment for Warzone-Related Posttraumatic Stress Disorder (PTSD) Completed NCT01564667
19 Service Member Fatigue and Lack of Motivation Following Concussion Completed NCT01496586
20 Functional Neuroanatomy and Regional Metabolism Before and After Treatment With Duloxetine Completed NCT02658617
21 Depression Online Assessment and Therapy Completed NCT02112266
22 Stress Management for Irritable Bowel Syndrome Completed NCT01886027
23 Mindfulness for Irritable Bowel Syndrome Completed NCT02794376
24 Plasticity of the Compassionate Brain Completed NCT01833104
25 Positive Emotion Regulation Training in Children, Adolescents and Young Adults With and Without Developmental Disorder Recruiting NCT02898298
26 CBT-Eb Plus EMDR Versus CBT-Eb in Patients With Eating Disorders Recruiting NCT03156959
27 Oculomotor Markers and Attachment in Adolescents Recruiting NCT02851810
28 Randomized Controlled Study of the Efficacy of Hypnosis Versus Relaxation and Control in Neuropathic Pain Recruiting NCT02256371
29 Student Outcomes of Integrative Mental Health Services Recruiting NCT02877875
30 A SYNdemic BASed INtervention for MSM With High Risk Behavior: Design of a Randomized Controlled Trial Active, not recruiting NCT02859935
31 Mental Training for CFS Following EBV Infection in Adolescents Active, not recruiting NCT02499302
32 Psychological Variables and Hyperglycemia in Diabetes Mellitus Enrolling by invitation NCT01714986
33 Development of Reward Processing in Prenatally Exposed Adolescents and Young Adults Enrolling by invitation NCT03268759
34 Training to Reconnect With Emotional Awareness Therapy Not yet recruiting NCT03414463
35 Asthma, Smoking, Emotional Deficits Not yet recruiting NCT03312673
36 Childhood Trauma in Schizophrenia: Exploration of Links Between Gene Expression, Cerebral Morphology and Symptomatology Not yet recruiting NCT03355781

Search NIH Clinical Center for Alexithymia

Genetic Tests for Alexithymia

Anatomical Context for Alexithymia

MalaCards organs/tissues related to Alexithymia:

38
Brain, Testes, Breast, Cortex, Heart, Skin, Thyroid

Publications for Alexithymia

Articles related to Alexithymia:

(show top 50) (show all 678)
# Title Authors Year
1
The influence of alexithymia on mobile phone addiction: The role of depression, anxiety and stress. ( 28926906 )
2018
2
Headache and Alexithymia in Children and Adolescents: What Is the Connection? ( 29449820 )
2018
3
Alexithymia as a potential source of symptom over-reporting: An exploratory study in forensic patients and non-forensic participants. ( 29349809 )
2018
4
Attachment avoidance, alexithymia, and gender: Examining their associations with distress disclosure tendencies and event-specific disclosure. ( 29355345 )
2018
5
Childhood Trauma and Functional Variants of 5-HTTLPR Are Independently Associated with Alexithymia in 5,283 Subjects from the General Population. ( 29306941 )
2018
6
Association of Internet addiction and alexithymia - A scoping review. ( 29429757 )
2018
7
Do terrorists suffer from alexithymia? ( 29417660 )
2018
8
Body talk: Sex differences in the influence of alexithymia on physical complaints among psychiatric outpatients. ( 29309955 )
2018
9
Assessing advanced theory of mind and alexithymia in patients suffering from enduring borderline personality disorder. ( 29360051 )
2018
10
Language and alexithymia: Evidence for the role of the inferior frontal gyrus in acquired alexithymia. ( 29360519 )
2018
11
The Impact of Alexithymia on Emotion Dysregulation in Anorexia Nervosa and Bulimia Nervosa over Time. ( 29266572 )
2018
12
Affect labeling and other aspects of emotional experiences in relation to alexithymia following standardized emotion inductions. ( 29428774 )
2018
13
Alexithymia as a mediator of the relationship between child sexual abuse and psychological distress in adolescence: A short-term longitudinal study. ( 29274605 )
2017
14
Depression differed by midnight cortisol secretion, alexithymia and anxiety between diabetes types: a cross sectional comparison. ( 28931368 )
2017
15
Alexithymia as a health risk and resilience factor: Response to Dr. Davydov. ( 28802740 )
2017
16
Alexithymia as a Moderator of Treatment Outcomes in a Randomized Controlled Trial on Brief Psychodynamic Interpersonal Psychotherapy for Patients with Multisomatoform Disorder. ( 27884003 )
2017
17
Prevalence and associated factors of alexithymia among adult prisoners in China: a cross-sectional study. ( 28768497 )
2017
18
Alexithymia as a health risk and resilience factor. ( 28867426 )
2017
19
Parental Alexithymia, Depression and Anxiety Levels of Children with Neurodevelopmental Disorders: A Comparative Study with Pervasive Developmental Disorders and ADHD. ( 29290095 )
2017
20
Contrasting metacognitive, social cognitive and alexithymia profiles in adults with borderline personality disorder, schizophrenia and substance use disorder. ( 28826064 )
2017
21
Cognitive factors and post-partum depression: What is the influence of general personality traits, rumination, maternal self-esteem, and alexithymia? ( 29282785 )
2017
22
Alexithymia, Defenses, and Ego Strength: Cross-sectional and Longitudinal Relationships with Psychological Well-Being and Depression. ( 29375250 )
2017
23
Childhood maltreatment is associated with attachment insecurities, dissociation and alexithymia in bipolar disorder. ( 29253803 )
2017
24
Optimizing trauma-informed intervention for intimate partner violence in veterans: The role of alexithymia. ( 28826068 )
2017
25
The association of experience of violence and somatization, depression, and alexithymia: a sample of women with medically unexplained symptoms in Turkey. ( 28752259 )
2017
26
The Impact of Alexithymia on Desire for Alcohol during a Social Stress Test. ( 28910184 )
2017
27
Visual Attention to Ambiguous Emotional Faces in Eating Disorders: Role of Alexithymia. ( 28762613 )
2017
28
Reductions in Alexithymia and Emotion Dysregulation After Training Emotional Self-Awareness Following Traumatic Brain Injury: A Phase I Trial. ( 28060205 )
2017
29
"Lacking warmth": Alexithymia trait is related to warm-specific thermal somatosensory processing. ( 28735971 )
2017
30
Rash Impulsiveness and Negative Mood, but not Alexithymia or Reward Sensitivity, Differentiate Young to Middle-Aged Chronic Daily Smokers from Never-Smokers. ( 28895792 )
2017
31
Mediator role of experiential avoidance in relationship of perceived stress and alexithymia with mental health. ( 28730586 )
2017
32
Relationship between pathological gambling, alexithymia, and gambling type. ( 28211964 )
2017
33
Do Emotional Components of Alexithymia Mediate the Interplay between Cyberbullying Victimization and Perpetration? ( 29292720 )
2017
34
Maternal Alexithymia and Attachment Style: Which Relationship with Their Children's Headache Features and Psychological Profile? ( 29403425 )
2017
35
A Study of the Characteristics of Alexithymia and Emotion Regulation in Patients with Depression. ( 28765680 )
2017
36
Alexithymia in multiple sclerosis: A systematic review of literature. ( 28764994 )
2017
37
On the Processes Underlying the Relationship Between Alexithymia and Gambling Severity. ( 28866795 )
2017
38
Alexithymia and Suicide Risk in Psychiatric Disorders: A Mini-Review. ( 28855878 )
2017
39
Alexithymia and anesthetic bladder capacity in interstitial cystitis/bladder pain syndrome. ( 28789788 )
2017
40
Moderating Effects of Alexithymia on Associations between the Therapeutic Alliance and the Outcome of Brief Psychodynamic-Interpersonal Psychotherapy for Multisomatoform Disorder. ( 29255429 )
2017
41
Psychopathology and alexithymia in patients with psoriasis. ( 28954100 )
2017
42
The mediating effects of cognitive emotion regulation strategies on the relationship between alexithymia and physical symptoms: Evidence from Iranian asthmatic patients. ( 27898375 )
2017
43
Alexithymia as a Transdiagnostic Precursor to Empathy Abnormalities: The Functional Role of the Insula. ( 29312079 )
2017
44
The role of alexithymia and gastrointestinal-specific anxiety as predictors of treatment outcome in irritable bowel syndrome. ( 27940317 )
2016
45
Impulsivity, alexithymia and dissociation among pathological gamblers in different therapeutic settings: A multisample comparison study. ( 28029440 )
2016
46
Interpersonal-Psychological Theory, Alexithymia, and Personality Predict Suicide Ideation among Maladjusted Soldiers in Taiwan. ( 27883207 )
2016
47
Understanding the role of personality and alexithymia in food preferences and PROP taste perception. ( 26805725 )
2016
48
Alexithymia in patients with type 2 diabetes mellitus: the role of anxiety, depression, and glycemic control. ( 27499615 )
2016
49
An Examination of the Topology and Measurement of the Alexithymia Construct Using Network Analysis. ( 27217088 )
2016
50
Association of childhood trauma and panic symptom severity in panic disorder: Exploring the mediating role of alexithymia. ( 27474959 )
2016

Variations for Alexithymia

Expression for Alexithymia

Search GEO for disease gene expression data for Alexithymia.

Pathways for Alexithymia

GO Terms for Alexithymia

Cellular components related to Alexithymia according to GeneCards Suite gene sharing:

# Name GO ID Score Top Affiliating Genes
1 integral component of plasma membrane GO:0005887 9.02 ABCB4 DRD2 HTR1A OXTR SLC6A4

Biological processes related to Alexithymia according to GeneCards Suite gene sharing:

(show all 12)
# Name GO ID Score Top Affiliating Genes
1 response to hypoxia GO:0001666 9.58 ABCB4 DRD2 SLC6A4
2 social behavior GO:0035176 9.51 OXTR SLC6A4
3 response to organic cyclic compound GO:0014070 9.5 ABCB4 COMT OXTR
4 lactation GO:0007595 9.49 ABCB4 OXTR
5 response to cocaine GO:0042220 9.48 DRD2 OXTR
6 response to morphine GO:0043278 9.46 ABCB4 DRD2
7 response to amphetamine GO:0001975 9.43 DRD2 OXTR
8 vasoconstriction GO:0042310 9.37 HTR1A SLC6A4
9 response to estradiol GO:0032355 9.33 ABCB4 OXTR SLC6A4
10 dopamine metabolic process GO:0042417 9.26 COMT DRD2
11 response to drug GO:0042493 9.02 ABCB4 COMT DRD2 OXTR SLC6A4
12 sperm ejaculation GO:0042713 8.96 OXTR SLC6A4

Molecular functions related to Alexithymia according to GeneCards Suite gene sharing:

# Name GO ID Score Top Affiliating Genes
1 signal transducer activity GO:0004871 8.92 DRD2 HTR1A OXTR TAS2R38

Sources for Alexithymia

3 CDC
7 CNVD
9 Cosmic
10 dbSNP
11 DGIdb
16 ExPASy
18 FMA
27 GO
28 GTR
29 HGMD
30 HMDB
31 HPO
32 ICD10
33 ICD10 via Orphanet
34 ICD9CM
35 IUPHAR
36 KEGG
37 LifeMap
39 MedGen
41 MeSH
42 MESH via Orphanet
43 MGI
45 NCI
46 NCIt
47 NDF-RT
50 NINDS
51 Novoseek
53 OMIM
54 OMIM via Orphanet
58 PubMed
60 QIAGEN
65 SNOMED-CT via HPO
66 SNOMED-CT via Orphanet
67 TGDB
68 Tocris
69 UMLS
70 UMLS via Orphanet
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