Aliases & Classifications for Alexithymia

MalaCards integrated aliases for Alexithymia:

Name: Alexithymia 12 14

Classifications:



External Ids:

Disease Ontology 12 DOID:0060131

Summaries for Alexithymia

Disease Ontology : 12 An agnosia that is a deficiency in understanding, processing, or describing emotions.

MalaCards based summary : Alexithymia is related to antisocial personality disorder and personality disorder. An important gene associated with Alexithymia is ANKK1 (Ankyrin Repeat And Kinase Domain Containing 1), and among its related pathways/superpathways are cAMP signaling pathway and Selective Serotonin Reuptake Inhibitor Pathway, Pharmacodynamics. The drugs Sertraline and Serotonin have been mentioned in the context of this disorder. Affiliated tissues include brain, testes and breast, and related phenotype is Weakly decreased NFAT1-GFP nuclear translocation.

Wikipedia : 72 Alexithymia /ˌeɪlɛksəˈθaɪmiə/ is a personality construct characterized by the subclinical inability to... more...

Related Diseases for Alexithymia

Diseases related to Alexithymia via text searches within MalaCards or GeneCards Suite gene sharing:

(show top 50) (show all 166)
id Related Disease Score Top Affiliating Genes
1 antisocial personality disorder 29.7 ANKK1 DRD2
2 personality disorder 29.1 COMT DRD2 HTR1A SLC6A4
3 schizophrenia 28.6 COMT DRD2 HTR1A SLC6A4
4 social emotional agnosia 10.8
5 lymphocytic colitis 10.6 IL4 SLC6A4
6 intrahepatic gall duct cancer 10.5 COMT SLC6A4
7 intracranial cavernous angioma 10.4 DRD2 SLC6A4
8 placenta accreta 10.4 COMT IL4
9 splenic abscess 10.4 DRD2 SLC6A4
10 hyperthyroxinemia 10.4 DRD2 SLC6A4
11 rhinoscleroma 10.4 COMT DRD2
12 ornithosis 10.4 DRD2 SLC6A4
13 teebi kaurah syndrome 10.4 COMT DRD2
14 pyromania 10.4 DRD2 SLC6A4
15 c8 deficiency, type ii 10.4 COMT DRD2
16 ulcerative colitis 10.4 COMT DRD2
17 bladder hepatoid adenocarcinoma 10.3 DRD2 SLC6A4
18 familial partial lipodystrophy 10.3 OXTR SLC6A4
19 eosinophilia-myalgia syndrome 10.3 ANKK1 DRD2
20 pelvic inflammatory disease 10.3 DRD2 SLC6A4
21 hypertrophic elongation of cervix 10.3 CRP IL4
22 brain meningioma 10.3 COMT DRD2
23 suppurative periapical periodontitis 10.3 DRD2 SLC6A4
24 thoracic spinal canal and spinal cord meningioma 10.3 IL4 SLC6A4
25 esophagus melanoma 10.2 CRP IL4
26 acute female pelvic peritonitis 10.2 DRD2 SLC6A4
27 benign mammary dysplasia 10.2 CRP IL4
28 hemorrhagic cystitis 10.1 COMT DRD2 SLC6A4
29 conjunctival degeneration 10.1 HTR1A SLC6A4
30 pauci-immune glomerulonephritis with anca 10.1 COMT DRD2 SLC6A4
31 colon mucinous adenocarcinoma 10.1 COMT DRD2 SLC6A4
32 perinatal necrotizing enterocolitis 10.1 COMT DRD2 SLC6A4
33 anodontia 10.1 HTR1A SLC6A4
34 tinea pedis 10.1 HTR1A SLC6A4
35 dentin caries 10.1 IL4 TAS2R38
36 angiokeratoma of mibelli 10.1 HTR1A SLC6A4
37 eating disorder 10.1
38 hallucinogen dependence 10.1 ANKK1 DRD2 SLC6A4
39 alcoholic liver cirrhosis 10.1 ANKK1 DRD2 SLC6A4
40 acquired aneurysmal subarachnoid hemorrhage 10.0 HTR1A SLC6A4
41 parkinsonism-dystonia, infantile 10.0 ANKK1 COMT DRD2
42 somatoform disorder 10.0
43 mandibular cancer 10.0 HTR1A SLC6A4
44 colon adenocarcinoma 10.0 CRP IL4
45 ragweed sensitivity 10.0 CRP IL4
46 panic disorder 10.0
47 traumatic brain injury 9.9
48 brain injury 9.9
49 alcohol dependence 9.9
50 allergic hypersensitivity disease 9.9 DRD2 HTR1A

Graphical network of the top 20 diseases related to Alexithymia:



Diseases related to Alexithymia

Symptoms & Phenotypes for Alexithymia

GenomeRNAi Phenotypes related to Alexithymia according to GeneCards Suite gene sharing:

26
id Description GenomeRNAi Source Accession Score Top Affiliating Genes
1 Weakly decreased NFAT1-GFP nuclear translocation GR00359-A 8.92 ANKK1 COMT HTR1A SLC6A4

Drugs & Therapeutics for Alexithymia

Drugs for Alexithymia (from DrugBank, HMDB, Dgidb, PharmGKB, IUPHAR, NovoSeek, BitterDB):

(show all 37)
id Name Status Phase Clinical Trials Cas Number PubChem Id
1
Sertraline Approved Phase 4 79617-96-2 68617
2
Serotonin Phase 4,Phase 2 50-67-9 5202
3 Serotonin Agents Phase 4,Phase 2
4 Serotonin Uptake Inhibitors Phase 4
5 Neurotransmitter Agents Phase 4,Phase 2
6 Neurotransmitter Uptake Inhibitors Phase 4,Phase 2
7 Antidepressive Agents Phase 4
8 Psychotropic Drugs Phase 4,Phase 2
9
Oxytocin Approved, Vet_approved Phase 2 50-56-6 439302 53477758
10
3,4-Methylenedioxyamphetamine Experimental, Illicit Phase 2 4764-17-4 1614
11 Adrenergic Agents Phase 2
12 N-Methyl-3,4-methylenedioxyamphetamine Phase 2
13 Hallucinogens Phase 2
14 Oxytocics Phase 2
15
Acetylcysteine Approved, Investigational Phase 1 616-91-1 12035
16 Respiratory System Agents Phase 1
17 N-monoacetylcystine Phase 1
18 Vitamins Phase 1
19 Anti-Infective Agents Phase 1
20 Expectorants Phase 1
21 Antidotes Phase 1
22 Protective Agents Phase 1
23 Antiviral Agents Phase 1
24 Antioxidants Phase 1
25
Norepinephrine Approved 51-41-2 439260
26
Dopamine Approved 51-61-6, 62-31-7 681
27
Hydrocortisone Approved, Vet_approved 50-23-7 5754 657311
28
Cocaine Approved, Illicit 50-36-2 5760 446220
29 Analgesics
30 Serotonin and Noradrenaline Reuptake Inhibitors
31 Cortisol succinate
32 Dopamine Agents
33 Duloxetine Hydrochloride
34 Peripheral Nervous System Agents
35 Hydrocortisone 17-butyrate 21-propionate
36 Hydrocortisone acetate
37 Anti-Inflammatory Agents

Interventional clinical trials:

(show all 32)

id Name Status NCT ID Phase Drugs
1 Clinical Assessment and Psychosocial Impact of Psoriasis Completed NCT01964443 Phase 4
2 Cognitive Behavioral Therapy Versus Sertraline in the Treatment of Post-Traumatic Stress Disorder Completed NCT00391430 Phase 4 Sertraline
3 Pain and Stress Management for Fibromyalgia Completed NCT01287481 Phase 2
4 MDMA-assisted Therapy for Social Anxiety in Autistic Adults Completed NCT02008396 Phase 2 Placebo;MDMA
5 Ocytocine and Cerebral Activation in Relation With Attachement Recruiting NCT02847143 Phase 2 nasal oxytocin or placebo
6 Autism Oxytocin Brain Project Recruiting NCT03033784 Phase 2 Oxytocin;Oxytocin;Oxytocin;Placebo
7 Early Study of N-Acetylcysteine to Treat Deliberate Self-Harm in Adolescents Completed NCT01111734 Phase 1 fMRI
8 Neurobiological, Neuropsychological,Linguistic and Gestural Processes and Phenomena in Individuals With Alexithymia Unknown status NCT00830752
9 Psychological Impact in Diabetes: Intervention With Affect School and Basal Body Awareness Unknown status NCT01498614
10 Psychopathological Risk Factors Associated With Conversion From Mild Cognitive Impairment to Dementia Unknown status NCT01436552
11 The Emotion Builder: An Intervention for Emotional Deficits After Brain Injury Completed NCT02432300
12 Online Treatment of Trichotillomania Completed NCT02044237
13 Outcomes of Mentalization-Based Treatment for Borderline Personality Disorder Completed NCT03295838
14 Moderating Impact of Various Emotion Personality Factors on Salivary Cortisol Response to a TSST Completed NCT00451126
15 Effectiveness of Standard Emergency Department Psychiatric Treatment Associated With Treatment Delivery by a Suicide Prevention Center Completed NCT00641498
16 Service Member Fatigue and Lack of Motivation Following Concussion Completed NCT01496586
17 Attention Bias Modification Treatment for Warzone-Related Posttraumatic Stress Disorder (PTSD) Completed NCT01564667
18 Functional Neuroanatomy and Regional Metabolism Before and After Treatment With Duloxetine Completed NCT02658617
19 Depression Online Assessment and Therapy Completed NCT02112266
20 Stress Management for Irritable Bowel Syndrome Completed NCT01886027
21 Plasticity of the Compassionate Brain Completed NCT01833104
22 Positive Emotion Regulation Training in Children, Adolescents and Young Adults With and Without Developmental Disorder Recruiting NCT02898298
23 CBT-Eb Plus EMDR Versus CBT-Eb in Patients With Eating Disorders Recruiting NCT03156959
24 Oculomotor Markers and Attachment in Adolescents Recruiting NCT02851810
25 Randomized Controlled Study of the Efficacy of Hypnosis Versus Relaxation and Control in Neuropathic Pain Recruiting NCT02256371
26 Student Outcomes of Integrative Mental Health Services Recruiting NCT02877875
27 A SYNdemic BASed INtervention for MSM With High Risk Behavior: Design of a Randomized Controlled Trial Active, not recruiting NCT02859935
28 Mental Training for CFS Following EBV Infection in Adolescents Active, not recruiting NCT02499302
29 Halifax Treatment Refractory Depression Trial Active, not recruiting NCT01141426
30 Mindfulness for Irritable Bowel Syndrome Active, not recruiting NCT02794376
31 Psychological Variables and Hyperglycemia in Diabetes Mellitus Enrolling by invitation NCT01714986
32 Development of Reward Processing in Prenatally Exposed Adolescents and Young Adults Not yet recruiting NCT03268759

Search NIH Clinical Center for Alexithymia

Genetic Tests for Alexithymia

Anatomical Context for Alexithymia

MalaCards organs/tissues related to Alexithymia:

39
Brain, Testes, Breast, Heart, Cortex, Skin, Thyroid

Publications for Alexithymia

Articles related to Alexithymia:

(show top 50) (show all 658)
id Title Authors Year
1
The influence of alexithymia on mobile phone addiction: The role of depression, anxiety and stress. ( 28926906 )
2018
2
Mediator role of experiential avoidance in relationship of perceived stress and alexithymia with mental health. ( 28730586 )
2017
3
Optimizing trauma-informed intervention for intimate partner violence in veterans: The role of alexithymia. ( 28826068 )
2017
4
"Lacking warmth": Alexithymia trait is related to warm-specific thermal somatosensory processing. ( 28735971 )
2017
5
On the Processes Underlying the Relationship Between Alexithymia and Gambling Severity. ( 28866795 )
2017
6
The association of experience of violence and somatization, depression, and alexithymia: a sample of women with medically unexplained symptoms in Turkey. ( 28752259 )
2017
7
The mediating effects of cognitive emotion regulation strategies on the relationship between alexithymia and physical symptoms: Evidence from Iranian asthmatic patients. ( 27898375 )
2017
8
Relationship between pathological gambling, alexithymia, and gambling type. ( 28211964 )
2017
9
Alexithymia as a health risk and resilience factor: Response to Dr. Davydov. ( 28802740 )
2017
10
Contrasting metacognitive, social cognitive and alexithymia profiles in adults with borderline personality disorder, schizophrenia and substance use disorder. ( 28826064 )
2017
11
Psychopathology and alexithymia in patients with psoriasis. ( 28954100 )
2017
12
A Study of the Characteristics of Alexithymia and Emotion Regulation in Patients with Depression. ( 28765680 )
2017
13
Rash Impulsiveness and Negative Mood, but not Alexithymia or Reward Sensitivity, Differentiate Young to Middle-Aged Chronic Daily Smokers from Never-Smokers. ( 28895792 )
2017
14
Visual Attention to Ambiguous Emotional Faces in Eating Disorders: Role of Alexithymia. ( 28762613 )
2017
15
Prevalence and associated factors of alexithymia among adult prisoners in China: a cross-sectional study. ( 28768497 )
2017
16
Alexithymia as a health risk and resilience factor. ( 28867426 )
2017
17
Reductions in Alexithymia and Emotion Dysregulation After Training Emotional Self-Awareness Following Traumatic Brain Injury: A Phase I Trial. ( 28060205 )
2017
18
Alexithymia as a Moderator of Treatment Outcomes in a Randomized Controlled Trial on Brief Psychodynamic Interpersonal Psychotherapy for Patients with Multisomatoform Disorder. ( 27884003 )
2017
19
Depression differed by midnight cortisol secretion, alexithymia and anxiety between diabetes types: a cross sectional comparison. ( 28931368 )
2017
20
The Impact of Alexithymia on Desire for Alcohol during a Social Stress Test. ( 28910184 )
2017
21
Alexithymia and anesthetic bladder capacity in interstitial cystitis/bladder pain syndrome. ( 28789788 )
2017
22
Alexithymia and Suicide Risk in Psychiatric Disorders: A Mini-Review. ( 28855878 )
2017
23
Alexithymia in multiple sclerosis: A systematic review of literature. ( 28764994 )
2017
24
Alexithymia and psychosocial problems among Italian preadolescents. A latent class analysis approach. ( 27376760 )
2016
25
An Examination of the Topology and Measurement of the Alexithymia Construct Using Network Analysis. ( 27217088 )
2016
26
The Big Five personality dimensions and mental health: The mediating role of alexithymia. ( 27931909 )
2016
27
The association between depression and craving in alcohol dependency is moderated by gender and by alexithymia factors. ( 27137959 )
2016
28
Extreme sensory processing patterns show a complex association with depression, and impulsivity, alexithymia, and hopelessness. ( 28064114 )
2016
29
Effects of alexithymia and empathy on the neural processing of social and monetary rewards. ( 27866269 )
2016
30
Coping strategies, alexithymia and anxiety in young patients with food allergy. ( 27886387 )
2016
31
Reduced anticipation of negative emotional events in alexithymia. ( 27278856 )
2016
32
The role of alexithymia: An 8-year follow-up study of chronic pain patients. ( 27423355 )
2016
33
Touching the Lived Body in Patients with Medically Unexplained Symptoms. How an Integration of Hands-on Bodywork and Body Awareness in Psychotherapy may Help People with Alexithymia. ( 26973560 )
2016
34
What's in the name 'alexithymia'? A commentary on "Affective agnosia: Expansion of the alexithymia construct and a new opportunity to integrate and extend Freud's legacy.". ( 27235080 )
2016
35
Alexithymia in patients with type 2 diabetes mellitus: the role of anxiety, depression, and glycemic control. ( 27499615 )
2016
36
Alexithymia, not autism, is associated with impaired interoception. ( 27253723 )
2016
37
Alterations in the Emotional Regulation Process in Gambling Addiction: The Role of Anger and Alexithymia. ( 27550365 )
2016
38
From Childhood Trauma to Adult Dissociation: The Role of PTSD and Alexithymia. ( 27623153 )
2016
39
Describe Your Feelings: Body Illusion Related to Alexithymia in Adolescence. ( 27840618 )
2016
40
Cognitive Alexithymia Mediates the Association Between Avoidant Attachment and Interpersonal Problems in Patients With Somatoform Disorder. ( 27185015 )
2016
41
Health-related quality of life and its association with alexithymia and difficulties in emotion regulation in patients with psoriasis. ( 27565774 )
2016
42
Sense of alexithymia in patients with anxiety disorders comorbid with recurrent urticaria. ( 27143899 )
2016
43
Association of childhood trauma and panic symptom severity in panic disorder: Exploring the mediating role of alexithymia. ( 27474959 )
2016
44
Prevalence of alexithymia in patients with psoriasis and its association with disease burden: a multicentre observational study. ( 27995617 )
2016
45
Childhood Trauma and Alexithymia in Patients with Conversion Disorder. ( 27504555 )
2016
46
Investigation of facial emotion recognition, alexithymia, and levels of anxiety and depression in patients with somatic symptoms and related disorders. ( 27199559 )
2016
47
Alexithymia and psychopathology in patients with acute myocardial infarction. ( 27090044 )
2016
48
Association between the Catechol-O-Methyltransferase (COMT) ValA^a8/a8,Met Polymorphism and Alexithymia in Patients with Obsessive-Compulsive Disorder. ( 26996573 )
2016
49
Alexithymia, but not autism spectrum disorder, may be related to the production of emotional facial expressions. ( 27895883 )
2016
50
Predictors for DSM-5 nonsuicidal self-injury in female adolescent inpatients: The role of childhood maltreatment, alexithymia, and dissociation. ( 27088878 )
2016

Variations for Alexithymia

Expression for Alexithymia

Search GEO for disease gene expression data for Alexithymia.

Pathways for Alexithymia

GO Terms for Alexithymia

Biological processes related to Alexithymia according to GeneCards Suite gene sharing:

id Name GO ID Score Top Affiliating Genes
1 response to organic cyclic compound GO:0014070 9.5 COMT IL4 OXTR
2 response to cytokine GO:0034097 9.48 IL4 OXTR
3 social behavior GO:0035176 9.46 OXTR SLC6A4
4 response to cocaine GO:0042220 9.43 DRD2 OXTR
5 response to amphetamine GO:0001975 9.4 DRD2 OXTR
6 vasoconstriction GO:0042310 9.37 HTR1A SLC6A4
7 female pregnancy GO:0007565 9.33 COMT IL4 OXTR
8 dopamine metabolic process GO:0042417 9.26 COMT DRD2
9 response to drug GO:0042493 9.02 COMT DRD2 IL4 OXTR SLC6A4
10 sperm ejaculation GO:0042713 8.96 OXTR SLC6A4

Molecular functions related to Alexithymia according to GeneCards Suite gene sharing:

id Name GO ID Score Top Affiliating Genes
1 G-protein coupled receptor activity GO:0004930 9.26 DRD2 HTR1A OXTR TAS2R38
2 signal transducer activity GO:0004871 8.92 DRD2 HTR1A OXTR TAS2R38

Sources for Alexithymia

3 CDC
7 CNVD
9 Cosmic
10 dbSNP
11 DGIdb
16 ExPASy
18 FMA
28 GO
29 GTR
30 HGMD
31 HMDB
32 HPO
33 ICD10
34 ICD10 via Orphanet
35 ICD9CM
36 IUPHAR
37 KEGG
38 LifeMap
40 MedGen
42 MeSH
43 MESH via Orphanet
44 MGI
46 NCI
47 NCIt
48 NDF-RT
51 NINDS
52 Novoseek
54 OMIM
55 OMIM via Orphanet
59 PubMed
60 QIAGEN
65 SNOMED-CT via HPO
66 SNOMED-CT via Orphanet
67 TGDB
68 Tocris
69 UMLS
70 UMLS via Orphanet
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