MCID: ALK015
MIFTS: 32

Alk-Positive Anaplastic Large Cell Lymphoma malady

Cancer, Blood, Immune categories

Summaries for Alk-Positive Anaplastic Large Cell Lymphoma

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33MalaCards
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MalaCards: Alk-Positive Anaplastic Large Cell Lymphoma, also known as anaplastic large cell lymphoma, alk-positive, is related to anaplastic large cell lymphoma and b-cell lymphomas. An important gene associated with Alk-Positive Anaplastic Large Cell Lymphoma is ALK (anaplastic lymphoma receptor tyrosine kinase), and among its related pathways are IL-4 Signaling and its Primary Biological Effects in Different Immune Cell Types and Th17 Differentiation. The compounds estrogen and 20(s)-hydroxycholesterol have been mentioned in the context of this disorder. Related mouse phenotypes are limbs/digits/tail and tumorigenesis.

Aliases & Classifications for Alk-Positive Anaplastic Large Cell Lymphoma

Sources:
49Orphanet, 61UMLS, 26ICD10 via Orphanet, 25ICD10
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Classifications:

Malacards categories (disease lists): (See all malacards categories)
Global: Cancer
Anatomical: Blood, Immune


Aliases & Descriptions:

alk-positive anaplastic large cell lymphoma 49
anaplastic large cell lymphoma, alk-positive 61
ki-1+ anaplastic large cell lymphoma 61
alk+ anaplastic large cell lymphoma 49
alk+ alcl 49


External Ids:

ICD10 via Orphanet26 C83.3
ICD1025 C84.6

Related Diseases for Alk-Positive Anaplastic Large Cell Lymphoma

Sources:
17GeneCards, 18GeneDecks
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Diseases related to Alk-Positive Anaplastic Large Cell Lymphoma via text searches within MalaCards or GeneCards/GeneDecks gene sharing:

(show top 50)    (show all 71)
idRelated DiseaseScoreTop Affiliating Genes
1anaplastic large cell lymphoma32.0ALK, MUC1, JAK3, NPM1, TNFRSF8
2b-cell lymphomas30.6TNFRSF8, NPM1, PTPN6, ALK
3adenocarcinoma30.6LOX, MUC1, GLI1, PTPN6
4lymphomatoid papulosis30.6ALK, NPM1, TNFRSF8
5bone lymphoma10.7
6pediatric lymphoma10.7
7central nervous system lymphoma10.6
8breast lymphoma10.6
9peripheral t-cell lymphoma10.6
10pancreas lymphoma10.4
11hodgkin's lymphoma, nodular sclerosis10.4
12gastrointestinal lymphoma10.4
13lung lymphoma10.4
14inflammatory breast carcinoma10.4
15chronic myeloid leukemia10.4
16adult lymphoma10.4
17large cell carcinoma10.4
18anaplastic small cell lymphoma10.4
19central nervous system lymphoma, primary10.4
20tetraploidy10.4
21hypoxia10.4
22primary bone lymphoma10.4
23intravascular large b-cell lymphoma10.4
24primary cutaneous anaplastic large cell lymphoma10.4
25spindle cell sarcoma10.4
26asthma10.4
27syphilis10.4
28soft tissue sarcoma10.4
29alk-negative anaplastic large cell lymphoma10.2
30hepatitis10.0CD99
31arthritis10.0JAK3
32neuroblastoma10.0ALK
33hepatitis c10.0CD99
34acute leukemia10.0PTPN6, NPM1
35basal cell carcinoma10.0GLI1, SHH
36glioblastoma multiforme10.0GLI1, ALK
37pulmonary fibrosis10.0LOX
38colon cancer10.0JAK3, PPID, LOX
39myeloma10.0ALK, CEBPB, TNFRSF8
40rhabdomyosarcoma10.0ALK, CD99, GLI1
41reticulosarcoma10.0TNFRSF8, NPM1, ALK
42severe combined immunodeficiency10.0IL21, JAK3, TNFRSF8
43hepatitis b10.0CEBPB, DDB1, TNFRSF8
44malignant fibroxanthoma10.0TNFRSF8, MUC1, ALK
45psoriasis10.0LOX
46cutaneous t cell lymphoma10.0PTPN6, IL21, TNFRSF8
47peripheral primitive neuroectodermal tumor10.0ALK, CD99, TNFRSF8
48retinoblastoma10.0CEBPB, NPM1
49myeloid leukemia10.0NPM1, JAK3, PTPN6, CEBPB
50interstitial lung disease10.0MUC1

Graphical network of the top 20 diseases related to Alk-Positive Anaplastic Large Cell Lymphoma:



Diseases related to alk-positive anaplastic large cell lymphoma

Clinical Features for Alk-Positive Anaplastic Large Cell Lymphoma

Drugs & Therapeutics for Alk-Positive Anaplastic Large Cell Lymphoma

Sources:
5CenterWatch, 42NIH Clinical Center, 6ClinicalTrials
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Approved drugs:

Search CenterWatch for Alk-Positive Anaplastic Large Cell Lymphoma

Drug clinical trials:

Search ClinicalTrials for Alk-Positive Anaplastic Large Cell Lymphoma

Search NIH Clinical Center for Alk-Positive Anaplastic Large Cell Lymphoma

Search CenterWatch for Alk-Positive Anaplastic Large Cell Lymphoma

Genetic Tests for Alk-Positive Anaplastic Large Cell Lymphoma

Anatomical Context for Alk-Positive Anaplastic Large Cell Lymphoma

Animal Models for Alk-Positive Anaplastic Large Cell Lymphoma or affiliated genes

Sources:
37MGI, 28inGenious Targeting Laboratory
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MGI Mouse Phenotypes related to Alk-Positive Anaplastic Large Cell Lymphoma:

37
idDescriptionMGI Source AccessionScoreTop Affiliating Genes
1MP:000537110.2SALL4, GLI1
2MP:00020069.8CEBPB, TCF3, NPM1
3MP:00053819.6SALL4, JAK3, SHH, MUC1, GLI1, PTPN6
4MP:00107719.3LOX, NPM1, SHH, EBP, MUC1, TCF3
5MP:00053809.2SALL4, NPM1, SHH, EBP, GLI1, TCF3
6MP:00053789.1NPM1, SHH, EBP, GLI1, TCF3, PTPN6
7MP:00053979.1TNFRSF8, NPM1, JAK3, SHH, EBP, IL21R
8MP:00053879.1JAK3, NPM1, TNFRSF8, SALL4, SHH, IL21R
9MP:00053848.9TWIST1, SALL4, NPM1, JAK3, DDB1, SHH
10MP:00107688.7DDB1, JAK3, NPM1, SALL4, LOX, SHH

Publications for Alk-Positive Anaplastic Large Cell Lymphoma

Genetic Variations for Alk-Positive Anaplastic Large Cell Lymphoma

Expression for genes affiliated with Alk-Positive Anaplastic Large Cell Lymphoma

Sources:
1BioGPS, 15Gene Expression Omnibus DataSets
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Expression patterns in normal tissues for genes affiliated with Alk-Positive Anaplastic Large Cell Lymphoma

Search GEO for disease gene expression data for Alk-Positive Anaplastic Large Cell Lymphoma.

Pathways for genes affiliated with Alk-Positive Anaplastic Large Cell Lymphoma

Sources:
53R&D Systems, 38NCBI BioSystems Database, 30KEGG, 12EMD Millipore, 52QIAGEN
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Pathways related to Alk-Positive Anaplastic Large Cell Lymphoma according to GeneCards/GeneDecks:

idSuper pathways (with members indented)ScoreTop Affiliating Genes
110.2IL21, IL21R
2
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10.1IL21, IL21R, JAK3
3
Cytokine production by Th17 cells in CF (Mouse model)
10.1JAK3, IL21R, IL21
410.0JAK3, PTPN6, CEBPB
59.9PTPN6, IL21, IL21R, JAK3
6
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9.9JAK3, MUC1, IL21R, IL21
7
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9.6CEBPB, PTPN6, TCF3, IL21, TNFRSF8
8
Hide members
9.6TNFRSF8, JAK3, IL21R, IL21, CEBPB, ALK
9
Hide members
9.4TNFRSF8, JAK3, MUC1, IL21, TCF3, CEBPB

Compounds for genes affiliated with Alk-Positive Anaplastic Large Cell Lymphoma

Sources:
45Novoseek, 60Tocris Bioscience, 24HMDB
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Compounds related to Alk-Positive Anaplastic Large Cell Lymphoma according to GeneCards/GeneDecks:

(show all 13)
idCompoundScoreTop Affiliating Genes
1estrogen4510.5JAK3
220(s)-hydroxycholesterol6010.4SHH, GLI1
3ciliobrevin a6010.4SHH, GLI1
4sant-16010.4SHH, GLI1
5ay 9944 dihydrochloride6010.3GLI1, SHH
6cyclopamine45 6011.1GLI1, SHH
7gp 1304510.0CEBPB, PTPN6, JAK3
8[alcl]459.9ALK, MUC1, JAK3, NPM1, TNFRSF8
9paraffin459.7LOX, TNFRSF8, NPM1, MUC1, CD99, ALK
10vegf459.6LOX, JAK3, MUC1, CD99, PTPN6, TMSB10
11zinc45 2410.5SALL4, TNFRSF8, NPM1, DDB1, GLI1, PTPN6
12tyrosine459.2JAK3, NPM1, TNFRSF8, LOX, MUC1, IL21
13retinoic acid45 2410.1LOX, NPM1, MUC1, PTPN6, TMSB10, CEBPB

GO Terms for genes affiliated with Alk-Positive Anaplastic Large Cell Lymphoma

Sources:
16Gene Ontology
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Cellular components related to Alk-Positive Anaplastic Large Cell Lymphoma according to GeneCards/GeneDecks:

idNameGO IDScoreTop Affiliating Genes
1nucleusGO:0056348.7DDB1, PPID, NPM1, SALL4, SHH, GLI1
2cytoplasmGO:0057378.1CEBPB, SALL4, TNFRSF8, NPM1, PPID, DDB1

Biological processes related to Alk-Positive Anaplastic Large Cell Lymphoma according to GeneCards/GeneDecks:

(show all 7)
idNameGO IDScoreTop Affiliating Genes
1ventral midline developmentGO:00741810.3GLI1, SHH
2smoothened signaling pathway involved in regulation of cerebellar granule cell precursor cell proliferationGO:02193810.3GLI1, SHH
3positive regulation of smoothened signaling pathwayGO:04588010.2GLI1, SHH
4regulation of G1/S transition of mitotic cell cycleGO:200004510.1TCF3, PTPN6
5lung developmentGO:03032410.0GLI1, SHH, LOX
6cell developmentGO:0484689.9TCF3, SHH
7positive regulation of transcription from RNA polymerase II promoterGO:0459449.7SALL4, JAK3, SHH, GLI1, TCF3, TWIST1

Molecular functions related to Alk-Positive Anaplastic Large Cell Lymphoma according to GeneCards/GeneDecks:

idNameGO IDScoreTop Affiliating Genes
1bHLH transcription factor bindingGO:04342510.2TWIST1, TCF3
2transcription factor bindingGO:0081349.5PPID, TCF3, CEBPB, TWIST1
3protein bindingGO:0055158.3ALK, LOX, NPM1, PPID, JAK3, DDB1

Products for genes affiliated with Alk-Positive Anaplastic Large Cell Lymphoma

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Sources for Alk-Positive Anaplastic Large Cell Lymphoma

3CDC
13ExPASy
14FMA
22GTR
23HGMD
24HMDB
25ICD10
26ICD10 via Orphanet
27ICD9CM
29IUPHAR
30KEGG
35MeSH
36MESH via Orphanet
37MGI
40NCIt
41NDF-RT
44NINDS
45Novoseek
47OMIM
48OMIM via Orphanet
51PubMed
52QIAGEN
58SNOMED-CT via Orphanet
61UMLS
62UMLS via Orphanet