MCID: ALK015
MIFTS: 37

Alk-Positive Anaplastic Large Cell Lymphoma malady

Cancer diseases, Blood diseases, Immune diseases categories

Summaries for Alk-Positive Anaplastic Large Cell Lymphoma

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MalaCards: Alk-Positive Anaplastic Large Cell Lymphoma, also known as anaplastic large cell lymphoma, alk-positive, is related to anaplastic large cell lymphoma and leukemia. An important gene associated with Alk-Positive Anaplastic Large Cell Lymphoma is ALK (anaplastic lymphoma receptor tyrosine kinase), and among its related pathways are IL-4 Signaling and its Primary Biological Effects in Different Immune Cell Types and Th17 Differentiation. The compounds estrogen and 20(s)-hydroxycholesterol have been mentioned in the context of this disorder. Related mouse phenotypes are limbs/digits/tail and tumorigenesis.

Aliases & Classifications for Alk-Positive Anaplastic Large Cell Lymphoma

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48Orphanet, 60UMLS, 26ICD10 via Orphanet, 25ICD10
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Classifications:

Malacards categories (disease lists): (See all malacards categories)
Global: Cancer diseases
Anatomical: Blood diseases, Immune diseases


Aliases & Descriptions:

alk-positive anaplastic large cell lymphoma 48
anaplastic large cell lymphoma, alk-positive 60
ki-1+ anaplastic large cell lymphoma 60
alk+ anaplastic large cell lymphoma 48
alk+ alcl 48


External Ids:

ICD10 via Orphanet26 C83.3
ICD1025 C84.6

Related Diseases for Alk-Positive Anaplastic Large Cell Lymphoma

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17GeneCards, 18GeneDecks
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Diseases related to Alk-Positive Anaplastic Large Cell Lymphoma via text searches within MalaCards or GeneCards/GeneDecks gene sharing:

(show top 50)    (show all 66)
idRelated DiseaseScoreTop Affiliating Genes
1anaplastic large cell lymphoma32.0ALK, MUC1, JAK3, NPM1, TNFRSF8
2leukemia30.8LOX, NPM1, JAK3, CD99, TCF3, PTPN6
3myeloid leukemia30.6NPM1, JAK3, PTPN6, CEBPB
4adenocarcinoma30.6LOX, MUC1, GLI1, PTPN6
5sarcoma30.5LOX, MUC1, GLI1, CD99, TWIST1, ALK
6bone lymphoma10.7
7pediatric lymphoma10.7
8central nervous system lymphoma10.6
9breast lymphoma10.6
10hodgkin's lymphoma10.6
11pancreas lymphoma10.4
12hodgkin's lymphoma, nodular sclerosis10.4
13gastrointestinal lymphoma10.4
14lung lymphoma10.4
15inflammatory breast carcinoma10.4
16chronic myeloid leukemia10.4
17gastroduodenitis10.4
18adult lymphoma10.4
19large cell carcinoma10.4
20chronic lymphocytic leukemia10.4
21esophagitis10.4
22lung adenocarcinoma10.4
23alk-negative anaplastic large cell lymphoma10.4
24asthma10.4
25syphilis10.4
26hepatitis10.0CD99
27arthritis10.0JAK3
28neuroblastoma10.0ALK
29hepatitis c10.0CD99
30acute leukemia10.0PTPN6, NPM1
31basal cell carcinoma10.0GLI1, SHH
32glioblastoma multiforme10.0GLI1, ALK
33pulmonary fibrosis10.0LOX
34colon cancer10.0JAK3, PPID, LOX
35myeloma10.0ALK, CEBPB, TNFRSF8
36rhabdomyosarcoma10.0ALK, CD99, GLI1
37reticulosarcoma10.0TNFRSF8, NPM1, ALK
38severe combined immunodeficiency10.0IL21, JAK3, TNFRSF8
39lymphomatoid papulosis10.0ALK, NPM1, TNFRSF8
40hepatitis b10.0CEBPB, DDB1, TNFRSF8
41malignant fibroxanthoma10.0TNFRSF8, MUC1, ALK
42psoriasis10.0LOX
43cutaneous t cell lymphoma10.0PTPN6, IL21, TNFRSF8
44peripheral primitive neuroectodermal tumor10.0ALK, CD99, TNFRSF8
45retinoblastoma10.0CEBPB, NPM1
46interstitial lung disease10.0MUC1
47nasopharynx carcinoma10.0TNFRSF8, CD99, TWIST1
48acute promyelocytic leukemia10.0CEBPB, PTPN6, NPM1
49melanoma10.0LOX, GLI1, IL21, TMSB10
50rheumatoid arthritis10.0IL21, IL21R, JAK3, TNFRSF8

Graphical network of the top 20 diseases related to Alk-Positive Anaplastic Large Cell Lymphoma:



Diseases related to alk-positive anaplastic large cell lymphoma

Clinical Features for Alk-Positive Anaplastic Large Cell Lymphoma

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Drugs & Therapeutics for Alk-Positive Anaplastic Large Cell Lymphoma

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5CenterWatch, 41NIH Clinical Center, 6ClinicalTrials
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Approved drugs:

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Drug clinical trials:

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Genetic Tests for Alk-Positive Anaplastic Large Cell Lymphoma

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Anatomical Context for Alk-Positive Anaplastic Large Cell Lymphoma

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Animal Models for Alk-Positive Anaplastic Large Cell Lymphoma or affiliated genes

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36MGI
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MGI Mouse Phenotypes related to Alk-Positive Anaplastic Large Cell Lymphoma:

36
idDescriptionMGI Source AccessionScoreTop Affiliating Genes
1MP:000537110.2SALL4, GLI1
2MP:00020069.8CEBPB, TCF3, NPM1
3MP:00053819.6SALL4, JAK3, SHH, MUC1, GLI1, PTPN6
4MP:00107719.3LOX, NPM1, SHH, EBP, MUC1, TCF3
5MP:00053809.2SALL4, NPM1, SHH, EBP, GLI1, TCF3
6MP:00053789.1NPM1, SHH, EBP, GLI1, TCF3, PTPN6
7MP:00053979.1TNFRSF8, NPM1, JAK3, SHH, EBP, IL21R
8MP:00053879.1JAK3, NPM1, TNFRSF8, SALL4, SHH, IL21R
9MP:00053848.9TWIST1, SALL4, NPM1, JAK3, DDB1, SHH
10MP:00107688.7DDB1, JAK3, NPM1, SALL4, LOX, SHH

Publications for Alk-Positive Anaplastic Large Cell Lymphoma

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Genetic Variations for Alk-Positive Anaplastic Large Cell Lymphoma

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Expression for genes affiliated with Alk-Positive Anaplastic Large Cell Lymphoma

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1BioGPS, 15Gene Expression Omnibus DataSets
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Expression patterns in normal tissues for genes affiliated with Alk-Positive Anaplastic Large Cell Lymphoma

Search GEO for disease gene expression data for Alk-Positive Anaplastic Large Cell Lymphoma.

Pathways for genes affiliated with Alk-Positive Anaplastic Large Cell Lymphoma

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52R&D Systems, 37NCBI BioSystems Database, 29KEGG, 12EMD Millipore, 51QIAGEN
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Pathways related to Alk-Positive Anaplastic Large Cell Lymphoma according to GeneCards/GeneDecks:

idSuper pathways (with members indented)ScoreTop Affiliating Genes
110.2IL21, IL21R
2
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10.1IL21, IL21R, JAK3
3
Cytokine production by Th17 cells in CF (Mouse model)
10.1JAK3, IL21R, IL21
410.0JAK3, PTPN6, CEBPB
59.9PTPN6, IL21, IL21R, JAK3
6
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9.9JAK3, MUC1, IL21R, IL21
7
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9.6CEBPB, PTPN6, TCF3, IL21, TNFRSF8
8
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9.6TNFRSF8, JAK3, IL21R, IL21, CEBPB, ALK
9
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9.4TNFRSF8, JAK3, MUC1, IL21, TCF3, CEBPB

Compounds for genes affiliated with Alk-Positive Anaplastic Large Cell Lymphoma

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44Novoseek, 59Tocris Bioscience, 24HMDB
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Compounds related to Alk-Positive Anaplastic Large Cell Lymphoma according to GeneCards/GeneDecks:

(show all 13)
idCompoundScoreTop Affiliating Genes
1estrogen4410.5JAK3
220(s)-hydroxycholesterol5910.4SHH, GLI1
3ciliobrevin a5910.4SHH, GLI1
4sant-15910.4SHH, GLI1
5ay 9944 dihydrochloride5910.3GLI1, SHH
6cyclopamine44 5911.1GLI1, SHH
7gp 1304410.0CEBPB, PTPN6, JAK3
8[alcl]449.9ALK, MUC1, JAK3, NPM1, TNFRSF8
9paraffin449.7LOX, TNFRSF8, NPM1, MUC1, CD99, ALK
10vegf449.6LOX, JAK3, MUC1, CD99, PTPN6, TMSB10
11zinc44 2410.5SALL4, TNFRSF8, NPM1, DDB1, GLI1, PTPN6
12tyrosine449.2JAK3, NPM1, TNFRSF8, LOX, MUC1, IL21
13retinoic acid44 2410.1LOX, NPM1, MUC1, PTPN6, TMSB10, CEBPB

GO Terms for genes affiliated with Alk-Positive Anaplastic Large Cell Lymphoma

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16Gene Ontology
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Cellular components related to Alk-Positive Anaplastic Large Cell Lymphoma according to GeneCards/GeneDecks:

idNameGO IDScoreTop Affiliating Genes
1nucleusGO:0056348.7DDB1, PPID, NPM1, SALL4, SHH, GLI1
2cytoplasmGO:0057378.1CEBPB, SALL4, TNFRSF8, NPM1, PPID, DDB1

Biological processes related to Alk-Positive Anaplastic Large Cell Lymphoma according to GeneCards/GeneDecks:

(show all 7)
idNameGO IDScoreTop Affiliating Genes
1ventral midline developmentGO:00741810.3GLI1, SHH
2smoothened signaling pathway involved in regulation of cerebellar granule cell precursor cell proliferationGO:02193810.3GLI1, SHH
3positive regulation of smoothened signaling pathwayGO:04588010.2GLI1, SHH
4regulation of G1/S transition of mitotic cell cycleGO:200004510.1TCF3, PTPN6
5lung developmentGO:03032410.0GLI1, SHH, LOX
6cell developmentGO:0484689.9TCF3, SHH
7positive regulation of transcription from RNA polymerase II promoterGO:0459449.7SALL4, JAK3, SHH, GLI1, TCF3, TWIST1

Molecular functions related to Alk-Positive Anaplastic Large Cell Lymphoma according to GeneCards/GeneDecks:

idNameGO IDScoreTop Affiliating Genes
1bHLH transcription factor bindingGO:04342510.2TWIST1, TCF3
2transcription factor bindingGO:0081349.5PPID, TCF3, CEBPB, TWIST1
3protein bindingGO:0055158.3ALK, LOX, NPM1, PPID, JAK3, DDB1

Products for genes affiliated with Alk-Positive Anaplastic Large Cell Lymphoma

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  • Antibodies
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  • Antibodies

Sources for Alk-Positive Anaplastic Large Cell Lymphoma

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3CDC
13ExPASy
14FMA
22GTR
23HGMD
24HMDB
25ICD10
26ICD10 via Orphanet
27ICD9CM
28IUPHAR
29KEGG
34MeSH
35MESH via Orphanet
36MGI
39NCIt
40NDF-RT
43NINDS
44Novoseek
46OMIM
47OMIM via Orphanet
50PubMed
51QIAGEN
57SNOMED-CT via Orphanet
60UMLS
61UMLS via Orphanet