MCID: ALK015
MIFTS: 39

Alk-Positive Anaplastic Large Cell Lymphoma malady

Cancer diseases, Blood diseases, Rare diseases, Immune diseases categories
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Summaries for Alk-Positive Anaplastic Large Cell Lymphoma

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MalaCards based summary: Alk-Positive Anaplastic Large Cell Lymphoma, also known as anaplastic large cell lymphoma, alk-positive, is related to anaplastic large cell lymphoma and hodgkin's lymphoma. An important gene associated with Alk-Positive Anaplastic Large Cell Lymphoma is ALK (anaplastic lymphoma receptor tyrosine kinase), and among its related pathways are Regulation of Wnt-mediated beta catenin signaling and target gene transcription and Basal cell carcinoma. Affiliated tissues include bone, bone marrow and breast, and related mouse phenotypes are craniofacial and hearing/vestibular/ear.

Aliases & Classifications for Alk-Positive Anaplastic Large Cell Lymphoma

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Sources:
48Orphanet, 62UMLS, 26ICD10 via Orphanet, 25ICD10
See all sources

Alk-Positive Anaplastic Large Cell Lymphoma, Aliases & Descriptions:

Name: Alk-Positive Anaplastic Large Cell Lymphoma 48
Anaplastic Large Cell Lymphoma, Alk-Positive 62
Alk+ Anaplastic Large Cell Lymphoma 48
 
Alcl, Alk- 62
Alk+ Alcl 48


Classifications:

Malacards categories (disease lists): (See all malacards categories)
Global: Cancer diseases, Rare diseases
Anatomical: Blood diseases, Immune diseases


External Ids:

ICD10 via Orphanet26 C83.3
ICD1025 C84.6

Related Diseases for Alk-Positive Anaplastic Large Cell Lymphoma

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Graphical network of the top 20 diseases related to Alk-Positive Anaplastic Large Cell Lymphoma:



Diseases related to alk-positive anaplastic large cell lymphoma

Symptoms for Alk-Positive Anaplastic Large Cell Lymphoma

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Drugs & Therapeutics for Alk-Positive Anaplastic Large Cell Lymphoma

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Drug clinical trials:

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Search NIH Clinical Center for Alk-Positive Anaplastic Large Cell Lymphoma

Genetic Tests for Alk-Positive Anaplastic Large Cell Lymphoma

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Anatomical Context for Alk-Positive Anaplastic Large Cell Lymphoma

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MalaCards organs/tissues related to Alk-Positive Anaplastic Large Cell Lymphoma:

32
Bone, Bone marrow, Breast, Lymph node, Brain, Lung, Pancreas, Skin, Testes, Myeloid, B cells

Animal Models for Alk-Positive Anaplastic Large Cell Lymphoma or affiliated genes

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MGI Mouse Phenotypes related to Alk-Positive Anaplastic Large Cell Lymphoma:

36
idDescriptionMGI Source AccessionScoreTop Affiliating Genes
1MP:00053828.8SALL4, DVL3, DVL2
2MP:00053778.7DVL2, DVL3, SALL4
3MP:00053718.5SALL4, DVL3, DVL2
4MP:00053808.4SALL4, DVL3, DVL2, EBP

Publications for Alk-Positive Anaplastic Large Cell Lymphoma

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Articles related to Alk-Positive Anaplastic Large Cell Lymphoma:

(show top 50)    (show all 70)
idTitleAuthorsYear
1
Editor in Chief: Response to Eyre etA al. "ALK-positive anaplastic large cell lymphoma: current and future perspectives in adult and paediatric disease" (24953081)
2014
2
Brain metastasis of ALK positive anaplastic large cell lymphoma after a long-term disease free survival in an old adult. (24696735)
2014
3
Activating mutations in ALK kinase domain confer resistance to structurally unrelated ALK inhibitors in NPM-ALK-positive anaplastic large-cell lymphoma. (24509625)
2014
4
Use of targeted therapy for refractory ALK-positive anaplastic large cell lymphoma as a bridging strategy prior to allogeneic transplantation. (22820970)
2013
5
Primary central nervous system ALK positive anaplastic large cell lymphoma with predominantly leptomeningeal involvement in an adult. (23549832)
2013
6
Intravascular large B-cell lymphoma occurring 25 years after treatment of ALK-positive anaplastic large cell lymphoma. (23488602)
2013
7
Disheveled proteins promote cell growth and tumorigenicity in ALK-positive anaplastic large cell lymphoma. (23022960)
2013
8
Identification of a novel crosstalk between casein kinase 2I+ and NPM-ALK in ALK-positive anaplastic large cell lymphoma. (23153582)
2013
9
ALK-positive anaplastic large cell lymphoma presenting as intradural spinal mass: first reported case and review of literature. (23082771)
2013
10
ALK-positive anaplastic large cell lymphoma limited to the skin: clinical, histopathological and molecular analysis of 6 pediatric cases. A report from the ALCL99 study. (22773605)
2013
11
Reed-Sternberg-like cells of ALK-positive anaplastic large cell lymphoma with near-tetraploidy. (22250643)
2012
12
The expression and oncogenic effects of the embryonic stem cell marker SALL4 in ALK-positive anaplastic large cell lymphoma. (22743134)
2012
13
Unusual central nervous system presentation of ALK-positive anaplastic large cell lymphoma in a child. (23135034)
2012
14
The heat shock protein-90 co-chaperone, Cyclophilin 40, promotes ALK- positive, anaplastic large cell lymphoma viability and its expression is regulated by the NPM-ALK oncoprotein. (22681779)
2012
15
Prognostic impact of morphologic and phenotypic features of childhood ALK-positive anaplastic large-cell lymphoma: results of the ALCL99 study. (22084369)
2011
16
Education and Imaging: Gastrointestinal: gastroduodenal involvement of ALK-positive anaplastic large cell lymphoma. (21488949)
2011
17
Hypoxia-microRNA-16 downregulation induces VEGF expression in anaplastic lymphoma kinase (ALK)-positive anaplastic large-cell lymphomas. (21778999)
2011
18
Primary esophageal CD30-positive ALK-positive anaplastic large cell lymphoma: a case report and literature review. (20524084)
2011
19
NPM-ALK and the JunB transcription factor regulate the expression of cytotoxic molecules in ALK-positive, anaplastic large cell lymphoma. (21326808)
2011
20
ALK-positive anaplastic large cell lymphoma in a patient with chronic lymphocytic leukemia. (18794171)
2010
21
C/EBPI^ expression in ALK-positive anaplastic large cell lymphomas is required for cell proliferation and is induced by the STAT3 signaling pathway. (20015877)
2010
22
Studies of phosphoproteomic changes induced by nucleophosmin-anaplastic lymphoma kinase (ALK) highlight deregulation of tumor necrosis factor (TNF)/Fas/TNF-related apoptosis-induced ligand signaling pathway in ALK-positive anaplastic large cell lymphoma. (20393185)
2010
23
Primary ALK-positive anaplastic large cell lymphoma of the breast: a case report and review of the literature. (20168249)
2010
24
Cutaneous presentation of ALK-positive anaplastic large cell lymphoma following insect bites: evidence for an association in five cases. (19951975)
2010
25
ALK-positive anaplastic large cell lymphoma with dic(2;4)(p23;q33). (19036440)
2009
26
Intravascular ALK-positive anaplastic large-cell lymphoma mimicking inflammatory breast carcinoma. (19364961)
2009
27
Genomic profiling of pediatric ALK-positive anaplastic large cell lymphoma: a Children's Cancer and Leukaemia Group Study. (19691112)
2009
28
Sonic hedgehog signaling pathway is activated in ALK-positive anaplastic large cell lymphoma. (19244133)
2009
29
Reactive oxygen species and lipoxygenases regulate the oncogenicity of NPM-ALK-positive anaplastic large cell lymphomas. (19503098)
2009
30
Highly aggressive ALK-positive anaplastic large cell lymphoma with a leukemic phase and multi-organ involvement: a report of three cases and a review of the literature. (17396261)
2007
31
Nodal ALK positive anaplastic large cell lymphoma of the axilla with spontaneous regression. (17577798)
2007
32
CD4 T-helper responses to the anaplastic lymphoma kinase (ALK) protein in patients with ALK-positive anaplastic large-cell lymphoma. (17332315)
2007
33
Prognostic significance of circulating tumor cells in bone marrow or peripheral blood as detected by qualitative and quantitative PCR in pediatric NPM-ALK-positive anaplastic large-cell lymphoma. (17392503)
2007
34
Chronic myeloid leukemia as a secondary malignancy after ALK-positive anaplastic large cell lymphoma. (17889677)
2007
35
Prognostic significance of NPM-ALK fusion transcript overexpression in ALK-positive anaplastic large-cell lymphoma. (17464320)
2007
36
Global proteome profiling of NPM/ALK-positive anaplastic large cell lymphoma. (17560012)
2007
37
Restoration of shp1 expression by 5-AZA-2'-deoxycytidine is associated with downregulation of JAK3/STAT3 signaling in ALK-positive anaplastic large cell lymphoma. (16871283)
2006
38
JSI-124 (cucurbitacin I) inhibits Janus kinase-3/signal transducer and activator of transcription-3 signalling, downregulates nucleophosmin-anaplastic lymphoma kinase (ALK), and induces apoptosis in ALK-positive anaplastic large cell lymphoma cells. (16939498)
2006
39
NPM-ALK-dependent expression of the transcription factor CCAAT/enhancer binding protein beta in ALK-positive anaplastic large cell lymphoma. (16709933)
2006
40
Cardiac presentation of ALK positive anaplastic large cell lymphoma. (16313264)
2005
41
Selective inhibition of STAT3 induces apoptosis and G(1) cell cycle arrest in ALK-positive anaplastic large cell lymphoma. (15184887)
2004
42
Centrosome abnormalities in ALK-positive anaplastic large-cell lymphoma. (15385940)
2004
43
Haploidentical peripheral-blood stem-cell transplantation for ALK-positive anaplastic large-cell lymphoma. (14761818)
2004
44
c-kit is not expressed in Hodgkin disease and anaplastic lymphoma kinase (ALK)-positive anaplastic large cell lymphoma. (14656871)
2003
45
ALK-positive anaplastic large cell lymphoma with leukemic peripheral blood involvement is a clinicopathologic entity with an unfavorable prognosis. Report of three cases and review of the literature. (14560573)
2003
46
Primary ALK positive anaplastic large cell lymphoma of the pancreas. (12691166)
2003
47
ALK-positive anaplastic large-cell lymphoma: strong T and B anti-tumour responses may cause hypocellular aspects of lymph nodes mimicking inflammatory lesions. (12950232)
2003
48
Isolation of differentially expressed genes in NPM-ALK-positive anaplastic large cell lymphoma. (12181047)
2002
49
MUC1 (EMA) is preferentially expressed by ALK positive anaplastic large cell lymphoma, in the normally glycosylated or only partly hypoglycosylated form. (11729213)
2001
50
The cryptic inv(2)(p23q35) defines a new molecular genetic subtype of ALK-positive anaplastic large-cell lymphoma. (9763551)
1998

Variations for Alk-Positive Anaplastic Large Cell Lymphoma

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Expression for genes affiliated with Alk-Positive Anaplastic Large Cell Lymphoma

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Expression patterns in normal tissues for genes affiliated with Alk-Positive Anaplastic Large Cell Lymphoma

Search GEO for disease gene expression data for Alk-Positive Anaplastic Large Cell Lymphoma.

Pathways for genes affiliated with Alk-Positive Anaplastic Large Cell Lymphoma

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Pathways related to Alk-Positive Anaplastic Large Cell Lymphoma according to GeneCards/GeneDecks:

(show all 11)
idSuper pathways (with members indented)ScoreTop Affiliating Genes
19.4DVL3, SALL4
2
Show member pathways
9.3DVL3, DVL2
39.3DVL2, DVL3
4
Show member pathways
DNA damage response (only ATM dependent)37
Wnt Signaling Pathway and Pluripotency37
9.3DVL3, DVL2
59.3DVL3, DVL2
6
Show member pathways
9.3DVL3, DVL2
7
Show member pathways
Delta-Notch Signaling Pathway37
Notch Signaling Pathway37
9.3DVL2, DVL3
89.3DVL3, DVL2
9
Show member pathways
Translation Non genomic rapid action of Androgen Receptor60
9.3DVL3, DVL2
109.3DVL3, DVL2
119.3DVL3, DVL2

Compounds for genes affiliated with Alk-Positive Anaplastic Large Cell Lymphoma

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GO Terms for genes affiliated with Alk-Positive Anaplastic Large Cell Lymphoma

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Cellular components related to Alk-Positive Anaplastic Large Cell Lymphoma according to GeneCards/GeneDecks:

idNameGO IDScoreTop Affiliating Genes
1cell cortexGO:0059389.3DVL3, DVL2

Biological processes related to Alk-Positive Anaplastic Large Cell Lymphoma according to GeneCards/GeneDecks:

(show all 11)
idNameGO IDScoreTop Affiliating Genes
1non-canonical Wnt signaling pathwayGO:0355679.6DVL3, DVL2
2convergent extensionGO:0600269.6DVL3, DVL2
3Wnt signaling pathway, planar cell polarity pathwayGO:0600719.5DVL2, DVL3
4planar cell polarity pathway involved in neural tube closureGO:0901799.5DVL3, DVL2
5cochlea morphogenesisGO:0901039.5DVL3, DVL2
6positive regulation of JUN kinase activityGO:0435079.4DVL2, DVL3
7neural tube closureGO:0018439.4SALL4, DVL2
8canonical Wnt signaling pathwayGO:0600709.3DVL3, DVL2
9positive regulation of protein phosphorylationGO:0019349.2DVL2, DVL3
10Wnt signaling pathwayGO:0160559.0DVL3, DVL2
11signal transductionGO:0071658.8ALK, IL21, EBP

Molecular functions related to Alk-Positive Anaplastic Large Cell Lymphoma according to GeneCards/GeneDecks:

idNameGO IDScoreTop Affiliating Genes
1frizzled bindingGO:0051099.3DVL3, DVL2

Products for genes affiliated with Alk-Positive Anaplastic Large Cell Lymphoma

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Sources for Alk-Positive Anaplastic Large Cell Lymphoma

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3CDC
13ExPASy
14FMA
22GTR
23HGMD
24HMDB
25ICD10
26ICD10 via Orphanet
27ICD9CM
28IUPHAR
29KEGG
34MeSH
35MESH via Orphanet
36MGI
39NCIt
40NDF-RT
43NINDS
44Novoseek
46OMIM
47OMIM via Orphanet
51PubMed
52QIAGEN
58SNOMED-CT via Orphanet
62UMLS
63UMLS via Orphanet