MCID: ALK015
MIFTS: 38

Alk-Positive Anaplastic Large Cell Lymphoma malady

Cancer diseases, Blood diseases, Rare diseases, Immune diseases categories

Summaries for Alk-Positive Anaplastic Large Cell Lymphoma

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MalaCards: Alk-Positive Anaplastic Large Cell Lymphoma, also known as anaplastic large cell lymphoma, alk-positive, is related to anaplastic large cell lymphoma and hodgkin's lymphoma. An important gene associated with Alk-Positive Anaplastic Large Cell Lymphoma is ALK (anaplastic lymphoma receptor tyrosine kinase), and among its related pathways are Regulation of Wnt-mediated beta catenin signaling and target gene transcription and Basal cell carcinoma. Affiliated tissues include bone, bone marrow and breast, and related mouse phenotypes are craniofacial and hearing/vestibular/ear.

Aliases & Classifications for Alk-Positive Anaplastic Large Cell Lymphoma

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50Orphanet, 63UMLS, 27ICD10 via Orphanet, 26ICD10
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Classifications:

Malacards categories (disease lists): (See all malacards categories)
Global: Cancer diseases, Rare diseases
Anatomical: Blood diseases, Immune diseases


Aliases & Descriptions:

alk-positive anaplastic large cell lymphoma 50
anaplastic large cell lymphoma, alk-positive 63
ki-1+ anaplastic large cell lymphoma 63
alk+ anaplastic large cell lymphoma 50
alk+ alcl 50


External Ids:

ICD10 via Orphanet27 C83.3
ICD1026 C84.6

Related Diseases for Alk-Positive Anaplastic Large Cell Lymphoma

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18GeneCards, 19GeneDecks
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Diseases related to Alk-Positive Anaplastic Large Cell Lymphoma via text searches within MalaCards or GeneCards/GeneDecks gene sharing:

(show all 21)
idRelated DiseaseScoreTop Affiliating Genes
1anaplastic large cell lymphoma32.1ALK
2hodgkin's lymphoma10.6
3leukemia10.6
4inflammatory breast carcinoma10.5
5chronic myeloid leukemia10.5
6gastroduodenitis10.5
7adenocarcinoma10.5
8chronic lymphocytic leukemia10.5
9esophagitis10.5
10lung adenocarcinoma10.5
11myeloid leukemia10.5
12b-cell lymphomas10.5
13tetraploidy10.5
14hypoxia10.5
15intravascular large b-cell lymphoma10.5
16asthma10.4
17sarcoma10.4
18syphilis10.4
19soft tissue sarcoma10.4
20peripheral t-cell lymphoma10.3
21alk-negative anaplastic large cell lymphoma10.3

Graphical network of the top 20 diseases related to Alk-Positive Anaplastic Large Cell Lymphoma:



Diseases related to alk-positive anaplastic large cell lymphoma

Symptoms for Alk-Positive Anaplastic Large Cell Lymphoma

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Drugs & Therapeutics for Alk-Positive Anaplastic Large Cell Lymphoma

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6CenterWatch, 43NIH Clinical Center, 7ClinicalTrials
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Approved drugs:

Search CenterWatch for Alk-Positive Anaplastic Large Cell Lymphoma

Drug clinical trials:

Search ClinicalTrials for Alk-Positive Anaplastic Large Cell Lymphoma

Search NIH Clinical Center for Alk-Positive Anaplastic Large Cell Lymphoma

Search CenterWatch for Alk-Positive Anaplastic Large Cell Lymphoma

Genetic Tests for Alk-Positive Anaplastic Large Cell Lymphoma

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Anatomical Context for Alk-Positive Anaplastic Large Cell Lymphoma

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34MalaCards
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MalaCards organs/tissues related to Alk-Positive Anaplastic Large Cell Lymphoma:

34
Bone, Bone marrow, Breast, Skin, Lung, Lymph node, Myeloid, B cells, Pancreas

Animal Models for Alk-Positive Anaplastic Large Cell Lymphoma or affiliated genes

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38MGI
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MGI Mouse Phenotypes related to Alk-Positive Anaplastic Large Cell Lymphoma:

38
idDescriptionMGI Source AccessionScoreTop Affiliating Genes
1MP:00053828.8DVL2, DVL3, SALL4
2MP:00053778.7SALL4, DVL2, DVL3
3MP:00053718.5DVL3, DVL2, SALL4
4MP:00053808.4EBP, DVL2, DVL3, SALL4

Publications for Alk-Positive Anaplastic Large Cell Lymphoma

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53PubMed
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Articles related to Alk-Positive Anaplastic Large Cell Lymphoma:

(show top 50)    (show all 66)
idTitleAuthorsYear
1
Use of targeted therapy for refractory ALK-positive anaplastic large cell lymphoma as a bridging strategy prior to allogeneic transplantation. (22820970)
2013
2
Primary central nervous system ALK positive anaplastic large cell lymphoma with predominantly leptomeningeal involvement in an adult. (23549832)
2013
3
Intravascular large B-cell lymphoma occurring 25 years after treatment of ALK-positive anaplastic large cell lymphoma. (23488602)
2013
4
Disheveled proteins promote cell growth and tumorigenicity in ALK-positive anaplastic large cell lymphoma. (23022960)
2013
5
Identification of a novel crosstalk between casein kinase 2I+ and NPM-ALK in ALK-positive anaplastic large cell lymphoma. (23153582)
2013
6
ALK-positive anaplastic large cell lymphoma presenting as intradural spinal mass: first reported case and review of literature. (23082771)
2013
7
ALK-positive anaplastic large cell lymphoma limited to the skin: clinical, histopathological and molecular analysis of 6 pediatric cases. A report from the ALCL99 study. (22773605)
2013
8
Reed-Sternberg-like cells of ALK-positive anaplastic large cell lymphoma with near-tetraploidy. (22250643)
2012
9
The expression and oncogenic effects of the embryonic stem cell marker SALL4 in ALK-positive anaplastic large cell lymphoma. (22743134)
2012
10
Unusual central nervous system presentation of ALK-positive anaplastic large cell lymphoma in a child. (23135034)
2012
11
The heat shock protein-90 co-chaperone, Cyclophilin 40, promotes ALK- positive, anaplastic large cell lymphoma viability and its expression is regulated by the NPM-ALK oncoprotein. (22681779)
2012
12
Prognostic impact of morphologic and phenotypic features of childhood ALK-positive anaplastic large-cell lymphoma: results of the ALCL99 study. (22084369)
2011
13
Education and Imaging: Gastrointestinal: gastroduodenal involvement of ALK-positive anaplastic large cell lymphoma. (21488949)
2011
14
Hypoxia-microRNA-16 downregulation induces VEGF expression in anaplastic lymphoma kinase (ALK)-positive anaplastic large-cell lymphomas. (21778999)
2011
15
Primary esophageal CD30-positive ALK-positive anaplastic large cell lymphoma: a case report and literature review. (20524084)
2011
16
NPM-ALK and the JunB transcription factor regulate the expression of cytotoxic molecules in ALK-positive, anaplastic large cell lymphoma. (21326808)
2011
17
HuR-mediated control of C/EBPbeta mRNA stability and translation in ALK-positive anaplastic large cell lymphomas. (21343335)
2011
18
ALK-positive anaplastic large cell lymphoma in a patient with chronic lymphocytic leukemia. (18794171)
2010
19
C/EBPI^ expression in ALK-positive anaplastic large cell lymphomas is required for cell proliferation and is induced by the STAT3 signaling pathway. (20015877)
2010
20
Studies of phosphoproteomic changes induced by nucleophosmin-anaplastic lymphoma kinase (ALK) highlight deregulation of tumor necrosis factor (TNF)/Fas/TNF-related apoptosis-induced ligand signaling pathway in ALK-positive anaplastic large cell lymphoma. (20393185)
2010
21
Primary ALK-positive anaplastic large cell lymphoma of the breast: a case report and review of the literature. (20168249)
2010
22
Cutaneous presentation of ALK-positive anaplastic large cell lymphoma following insect bites: evidence for an association in five cases. (19951975)
2010
23
ALK-positive anaplastic large cell lymphoma with dic(2;4)(p23;q33). (19036440)
2009
24
Intravascular ALK-positive anaplastic large-cell lymphoma mimicking inflammatory breast carcinoma. (19364961)
2009
25
Genomic profiling of pediatric ALK-positive anaplastic large cell lymphoma: a Children's Cancer and Leukaemia Group Study. (19691112)
2009
26
Sonic hedgehog signaling pathway is activated in ALK-positive anaplastic large cell lymphoma. (19244133)
2009
27
Reactive oxygen species and lipoxygenases regulate the oncogenicity of NPM-ALK-positive anaplastic large cell lymphomas. (19503098)
2009
28
Highly aggressive ALK-positive anaplastic large cell lymphoma with a leukemic phase and multi-organ involvement: a report of three cases and a review of the literature. (17396261)
2007
29
Nodal ALK positive anaplastic large cell lymphoma of the axilla with spontaneous regression. (17577798)
2007
30
CD4 T-helper responses to the anaplastic lymphoma kinase (ALK) protein in patients with ALK-positive anaplastic large-cell lymphoma. (17332315)
2007
31
Prognostic significance of circulating tumor cells in bone marrow or peripheral blood as detected by qualitative and quantitative PCR in pediatric NPM-ALK-positive anaplastic large-cell lymphoma. (17392503)
2007
32
Chronic myeloid leukemia as a secondary malignancy after ALK-positive anaplastic large cell lymphoma. (17889677)
2007
33
Prognostic significance of NPM-ALK fusion transcript overexpression in ALK-positive anaplastic large-cell lymphoma. (17464320)
2007
34
Global proteome profiling of NPM/ALK-positive anaplastic large cell lymphoma. (17560012)
2007
35
Restoration of shp1 expression by 5-AZA-2'-deoxycytidine is associated with downregulation of JAK3/STAT3 signaling in ALK-positive anaplastic large cell lymphoma. (16871283)
2006
36
JSI-124 (cucurbitacin I) inhibits Janus kinase-3/signal transducer and activator of transcription-3 signalling, downregulates nucleophosmin-anaplastic lymphoma kinase (ALK), and induces apoptosis in ALK-positive anaplastic large cell lymphoma cells. (16939498)
2006
37
NPM-ALK-dependent expression of the transcription factor CCAAT/enhancer binding protein beta in ALK-positive anaplastic large cell lymphoma. (16709933)
2006
38
ALK-positive anaplastic large cell lymphoma mimicking nodular sclerosis Hodgkin's lymphoma: report of 10 cases. (16434897)
2006
39
Cardiac presentation of ALK positive anaplastic large cell lymphoma. (16313264)
2005
40
Immunoreactivity of CD99 in non-Hodgkin's lymphoma: unexpected frequent expression in ALK-positive anaplastic large cell lymphoma. (16361803)
2005
41
Selective inhibition of STAT3 induces apoptosis and G(1) cell cycle arrest in ALK-positive anaplastic large cell lymphoma. (15184887)
2004
42
Centrosome abnormalities in ALK-positive anaplastic large-cell lymphoma. (15385940)
2004
43
Haploidentical peripheral-blood stem-cell transplantation for ALK-positive anaplastic large-cell lymphoma. (14761818)
2004
44
c-kit is not expressed in Hodgkin disease and anaplastic lymphoma kinase (ALK)-positive anaplastic large cell lymphoma. (14656871)
2003
45
ALK-positive anaplastic large cell lymphoma with leukemic peripheral blood involvement is a clinicopathologic entity with an unfavorable prognosis. Report of three cases and review of the literature. (14560573)
2003
46
Primary ALK positive anaplastic large cell lymphoma of the pancreas. (12691166)
2003
47
ALK-positive anaplastic large-cell lymphoma: strong T and B anti-tumour responses may cause hypocellular aspects of lymph nodes mimicking inflammatory lesions. (12950232)
2003
48
Isolation of differentially expressed genes in NPM-ALK-positive anaplastic large cell lymphoma. (12181047)
2002
49
MUC1 (EMA) is preferentially expressed by ALK positive anaplastic large cell lymphoma, in the normally glycosylated or only partly hypoglycosylated form. (11729213)
2001
50
The cryptic inv(2)(p23q35) defines a new molecular genetic subtype of ALK-positive anaplastic large-cell lymphoma. (9763551)
1998

Variations for Alk-Positive Anaplastic Large Cell Lymphoma

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Expression for genes affiliated with Alk-Positive Anaplastic Large Cell Lymphoma

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2BioGPS, 16Gene Expression Omnibus DataSets
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Expression patterns in normal tissues for genes affiliated with Alk-Positive Anaplastic Large Cell Lymphoma

Search GEO for disease gene expression data for Alk-Positive Anaplastic Large Cell Lymphoma.

Pathways for genes affiliated with Alk-Positive Anaplastic Large Cell Lymphoma

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51PathCards, 39NCBI BioSystems Database, 31KEGG, 5Cell Signaling Technology, 56Reactome, 54QIAGEN, 61Thomson Reuters
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Pathways related to Alk-Positive Anaplastic Large Cell Lymphoma according to GeneCards/GeneDecks:

(show all 11)
idSuper pathways (with members indented)ScoreTop Affiliating Genes
19.4DVL3, SALL4
2
Show member pathways
9.3DVL3, DVL2
39.3DVL2, DVL3
4
Show member pathways
DNA damage response (only ATM dependent)39
Wnt Signaling Pathway and Pluripotency39
9.3DVL3, DVL2
59.3DVL3, DVL2
6
Show member pathways
9.3DVL3, DVL2
7
Show member pathways
Delta-Notch Signaling Pathway39
Notch Signaling Pathway39
9.3DVL2, DVL3
89.3DVL3, DVL2
9
Show member pathways
Translation Non genomic rapid action of Androgen Receptor61
9.3DVL3, DVL2
109.3DVL3, DVL2
119.3DVL3, DVL2

Compounds for genes affiliated with Alk-Positive Anaplastic Large Cell Lymphoma

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GO Terms for genes affiliated with Alk-Positive Anaplastic Large Cell Lymphoma

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17Gene Ontology
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Cellular components related to Alk-Positive Anaplastic Large Cell Lymphoma according to GeneCards/GeneDecks:

idNameGO IDScoreTop Affiliating Genes
1cell cortexGO:0059389.3DVL3, DVL2

Biological processes related to Alk-Positive Anaplastic Large Cell Lymphoma according to GeneCards/GeneDecks:

(show all 11)
idNameGO IDScoreTop Affiliating Genes
1non-canonical Wnt signaling pathwayGO:0355679.6DVL3, DVL2
2convergent extensionGO:0600269.6DVL3, DVL2
3Wnt signaling pathway, planar cell polarity pathwayGO:0600719.5DVL2, DVL3
4planar cell polarity pathway involved in neural tube closureGO:0901799.5DVL3, DVL2
5cochlea morphogenesisGO:0901039.5DVL3, DVL2
6positive regulation of JUN kinase activityGO:0435079.4DVL2, DVL3
7neural tube closureGO:0018439.4SALL4, DVL2
8canonical Wnt signaling pathwayGO:0600709.3DVL3, DVL2
9positive regulation of protein phosphorylationGO:0019349.2DVL2, DVL3
10Wnt signaling pathwayGO:0160559.0DVL3, DVL2
11signal transductionGO:0071658.8ALK, IL21, EBP

Molecular functions related to Alk-Positive Anaplastic Large Cell Lymphoma according to GeneCards/GeneDecks:

idNameGO IDScoreTop Affiliating Genes
1frizzled bindingGO:0051099.3DVL3, DVL2

Products for genes affiliated with Alk-Positive Anaplastic Large Cell Lymphoma

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Sources for Alk-Positive Anaplastic Large Cell Lymphoma

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4CDC
14ExPASy
15FMA
23GTR
24HGMD
25HMDB
26ICD10
27ICD10 via Orphanet
28ICD9CM
30IUPHAR
31KEGG
36MeSH
37MESH via Orphanet
38MGI
41NCIt
42NDF-RT
45NINDS
46Novoseek
48OMIM
49OMIM via Orphanet
53PubMed
54QIAGEN
60SNOMED-CT via Orphanet
63UMLS
64UMLS via Orphanet