MCID: ALK015
MIFTS: 39

Alk-Positive Anaplastic Large Cell Lymphoma malady

Cancer diseases, Blood diseases, Rare diseases, Immune diseases categories

Summaries for Alk-Positive Anaplastic Large Cell Lymphoma

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MalaCards based summary: Alk-Positive Anaplastic Large Cell Lymphoma, also known as anaplastic large cell lymphoma, alk-positive, is related to anaplastic large cell lymphoma and leukemia. An important gene associated with Alk-Positive Anaplastic Large Cell Lymphoma is ALK (anaplastic lymphoma receptor tyrosine kinase), and among its related pathways are Regulation of Wnt-mediated beta catenin signaling and target gene transcription and Basal cell carcinoma. Affiliated tissues include bone, bone marrow and breast, and related mouse phenotypes are craniofacial and hearing/vestibular/ear.

Aliases & Classifications for Alk-Positive Anaplastic Large Cell Lymphoma

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Sources:
49Orphanet, 62UMLS, 28ICD10 via Orphanet, 27ICD10
See all sources

Alk-Positive Anaplastic Large Cell Lymphoma, Aliases & Descriptions:

Name: Alk-Positive Anaplastic Large Cell Lymphoma 49
Anaplastic Large Cell Lymphoma, Alk-Positive 62
Alk+ Anaplastic Large Cell Lymphoma 49
 
Alcl, Alk- 62
Alk+ Alcl 49


Classifications:

Malacards categories (disease lists): (See all malacards categories)
Global: Cancer diseases, Rare diseases
Anatomical: Blood diseases, Immune diseases


Characteristics (Orphanet epidemiological data):

49
alk-positive anaplastic large cell lymphoma:
Inheritance: Not applicable; Age of onset: Adolescent,Adult,Childhood


External Ids:

Orphanet49 300895
ICD10 via Orphanet28 C83.3
ICD1027 C84.6

Related Diseases for Alk-Positive Anaplastic Large Cell Lymphoma

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Graphical network of the top 20 diseases related to Alk-Positive Anaplastic Large Cell Lymphoma:



Diseases related to alk-positive anaplastic large cell lymphoma

Symptoms for Alk-Positive Anaplastic Large Cell Lymphoma

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Drugs & Therapeutics for Alk-Positive Anaplastic Large Cell Lymphoma

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Drug clinical trials:

Search ClinicalTrials for Alk-Positive Anaplastic Large Cell Lymphoma

Search NIH Clinical Center for Alk-Positive Anaplastic Large Cell Lymphoma

Genetic Tests for Alk-Positive Anaplastic Large Cell Lymphoma

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Anatomical Context for Alk-Positive Anaplastic Large Cell Lymphoma

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MalaCards organs/tissues related to Alk-Positive Anaplastic Large Cell Lymphoma:

33
Bone, Bone marrow, Breast, Testes, Lymph node, Brain, Lung, Pancreas, Skin, Myeloid, B cells

Animal Models for Alk-Positive Anaplastic Large Cell Lymphoma or affiliated genes

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MGI Mouse Phenotypes related to Alk-Positive Anaplastic Large Cell Lymphoma:

37
idDescriptionMGI Source AccessionScoreTop Affiliating Genes
1MP:00053828.8DVL2, DVL3, SALL4
2MP:00053778.7SALL4, DVL2, DVL3
3MP:00053718.5DVL3, DVL2, SALL4
4MP:00053808.4EBP, DVL2, DVL3, SALL4

Publications for Alk-Positive Anaplastic Large Cell Lymphoma

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Articles related to Alk-Positive Anaplastic Large Cell Lymphoma:

(show top 50)    (show all 75)
idTitleAuthorsYear
1
The NADPH oxidase NOX5 protects against apoptosis in ALK-positive anaplastic large-cell lymphoma cell lines. (25797883)
2015
2
ALK Positive Anaplastic Large Cell Lymphoma Presenting as Extensive Bone Involvement. (25738071)
2015
3
Treatment Efficacy and Resistance Mechanisms Using the Second-Generation ALK Inhibitor AP26113 in Human NPM-ALK-Positive Anaplastic Large Cell Lymphoma. (25421750)
2015
4
Editor in Chief: Response to Eyre etA al. "ALK-positive anaplastic large cell lymphoma: current and future perspectives in adult and paediatric disease" (24953081)
2014
5
Brain metastasis of ALK positive anaplastic large cell lymphoma after a long-term disease free survival in an old adult. (24696735)
2014
6
ALK-positive anaplastic large cell lymphoma with an unusual alveolar growth pattern. (25674293)
2014
7
Activating mutations in ALK kinase domain confer resistance to structurally unrelated ALK inhibitors in NPM-ALK-positive anaplastic large-cell lymphoma. (24509625)
2014
8
Diagnosis of ALK-positive anaplastic large cell lymphoma based on CD30 testing. (25855891)
2014
9
Use of targeted therapy for refractory ALK-positive anaplastic large cell lymphoma as a bridging strategy prior to allogeneic transplantation. (22820970)
2013
10
Primary central nervous system ALK positive anaplastic large cell lymphoma with predominantly leptomeningeal involvement in an adult. (23549832)
2013
11
Intravascular large B-cell lymphoma occurring 25 years after treatment of ALK-positive anaplastic large cell lymphoma. (23488602)
2013
12
Disheveled proteins promote cell growth and tumorigenicity in ALK-positive anaplastic large cell lymphoma. (23022960)
2013
13
Identification of a novel crosstalk between casein kinase 2I+ and NPM-ALK in ALK-positive anaplastic large cell lymphoma. (23153582)
2013
14
ALK-positive anaplastic large cell lymphoma presenting as intradural spinal mass: first reported case and review of literature. (23082771)
2013
15
Reed-Sternberg-like cells of ALK-positive anaplastic large cell lymphoma with near-tetraploidy. (22250643)
2012
16
The expression and oncogenic effects of the embryonic stem cell marker SALL4 in ALK-positive anaplastic large cell lymphoma. (22743134)
2012
17
Unusual central nervous system presentation of ALK-positive anaplastic large cell lymphoma in a child. (23135034)
2012
18
Prognostic impact of morphologic and phenotypic features of childhood ALK-positive anaplastic large-cell lymphoma: results of the ALCL99 study. (22084369)
2011
19
Education and Imaging: Gastrointestinal: gastroduodenal involvement of ALK-positive anaplastic large cell lymphoma. (21488949)
2011
20
Hypoxia-microRNA-16 downregulation induces VEGF expression in anaplastic lymphoma kinase (ALK)-positive anaplastic large-cell lymphomas. (21778999)
2011
21
Primary esophageal CD30-positive ALK-positive anaplastic large cell lymphoma: a case report and literature review. (20524084)
2011
22
NPM-ALK and the JunB transcription factor regulate the expression of cytotoxic molecules in ALK-positive, anaplastic large cell lymphoma. (21326808)
2011
23
ALK-positive anaplastic large cell lymphoma in a patient with chronic lymphocytic leukemia. (18794171)
2010
24
C/EBPI^ expression in ALK-positive anaplastic large cell lymphomas is required for cell proliferation and is induced by the STAT3 signaling pathway. (20015877)
2010
25
Studies of phosphoproteomic changes induced by nucleophosmin-anaplastic lymphoma kinase (ALK) highlight deregulation of tumor necrosis factor (TNF)/Fas/TNF-related apoptosis-induced ligand signaling pathway in ALK-positive anaplastic large cell lymphoma. (20393185)
2010
26
Primary ALK-positive anaplastic large cell lymphoma of the breast: a case report and review of the literature. (20168249)
2010
27
Cutaneous presentation of ALK-positive anaplastic large cell lymphoma following insect bites: evidence for an association in five cases. (19951975)
2010
28
ALK-positive anaplastic large cell lymphoma with dic(2;4)(p23;q33). (19036440)
2009
29
Intravascular ALK-positive anaplastic large-cell lymphoma mimicking inflammatory breast carcinoma. (19364961)
2009
30
Genomic profiling of pediatric ALK-positive anaplastic large cell lymphoma: a Children's Cancer and Leukaemia Group Study. (19691112)
2009
31
Sonic hedgehog signaling pathway is activated in ALK-positive anaplastic large cell lymphoma. (19244133)
2009
32
Reactive oxygen species and lipoxygenases regulate the oncogenicity of NPM-ALK-positive anaplastic large cell lymphomas. (19503098)
2009
33
Highly aggressive ALK-positive anaplastic large cell lymphoma with a leukemic phase and multi-organ involvement: a report of three cases and a review of the literature. (17396261)
2007
34
Nodal ALK positive anaplastic large cell lymphoma of the axilla with spontaneous regression. (17577798)
2007
35
CD4 T-helper responses to the anaplastic lymphoma kinase (ALK) protein in patients with ALK-positive anaplastic large-cell lymphoma. (17332315)
2007
36
Prognostic significance of circulating tumor cells in bone marrow or peripheral blood as detected by qualitative and quantitative PCR in pediatric NPM-ALK-positive anaplastic large-cell lymphoma. (17392503)
2007
37
Chronic myeloid leukemia as a secondary malignancy after ALK-positive anaplastic large cell lymphoma. (17889677)
2007
38
Prognostic significance of NPM-ALK fusion transcript overexpression in ALK-positive anaplastic large-cell lymphoma. (17464320)
2007
39
Global proteome profiling of NPM/ALK-positive anaplastic large cell lymphoma. (17560012)
2007
40
Restoration of shp1 expression by 5-AZA-2'-deoxycytidine is associated with downregulation of JAK3/STAT3 signaling in ALK-positive anaplastic large cell lymphoma. (16871283)
2006
41
JSI-124 (cucurbitacin I) inhibits Janus kinase-3/signal transducer and activator of transcription-3 signalling, downregulates nucleophosmin-anaplastic lymphoma kinase (ALK), and induces apoptosis in ALK-positive anaplastic large cell lymphoma cells. (16939498)
2006
42
Cardiac presentation of ALK positive anaplastic large cell lymphoma. (16313264)
2005
43
Selective inhibition of STAT3 induces apoptosis and G(1) cell cycle arrest in ALK-positive anaplastic large cell lymphoma. (15184887)
2004
44
Centrosome abnormalities in ALK-positive anaplastic large-cell lymphoma. (15385940)
2004
45
Haploidentical peripheral-blood stem-cell transplantation for ALK-positive anaplastic large-cell lymphoma. (14761818)
2004
46
c-kit is not expressed in Hodgkin disease and anaplastic lymphoma kinase (ALK)-positive anaplastic large cell lymphoma. (14656871)
2003
47
ALK-positive anaplastic large cell lymphoma with leukemic peripheral blood involvement is a clinicopathologic entity with an unfavorable prognosis. Report of three cases and review of the literature. (14560573)
2003
48
Isolation of differentially expressed genes in NPM-ALK-positive anaplastic large cell lymphoma. (12181047)
2002
49
MUC1 (EMA) is preferentially expressed by ALK positive anaplastic large cell lymphoma, in the normally glycosylated or only partly hypoglycosylated form. (11729213)
2001
50
The cryptic inv(2)(p23q35) defines a new molecular genetic subtype of ALK-positive anaplastic large-cell lymphoma. (9763551)
1998

Variations for Alk-Positive Anaplastic Large Cell Lymphoma

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Expression for genes affiliated with Alk-Positive Anaplastic Large Cell Lymphoma

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Search GEO for disease gene expression data for Alk-Positive Anaplastic Large Cell Lymphoma.

Pathways for genes affiliated with Alk-Positive Anaplastic Large Cell Lymphoma

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Pathways related to Alk-Positive Anaplastic Large Cell Lymphoma according to GeneCards/GeneDecks:

(show all 11)
idSuper pathways (with members indented)ScoreTop Affiliating Genes
19.4DVL3, SALL4
2
Show member pathways
9.3DVL3, DVL2
39.3DVL2, DVL3
4
Show member pathways
DNA damage response (only ATM dependent)38
Wnt Signaling Pathway and Pluripotency38
9.3DVL3, DVL2
59.3DVL3, DVL2
6
Show member pathways
9.3DVL3, DVL2
7
Show member pathways
Delta-Notch Signaling Pathway38
Notch Signaling Pathway38
9.3DVL2, DVL3
89.3DVL3, DVL2
9
Show member pathways
Translation Non genomic rapid action of Androgen Receptor60
9.3DVL3, DVL2
109.3DVL3, DVL2
119.3DVL3, DVL2

Compounds for genes affiliated with Alk-Positive Anaplastic Large Cell Lymphoma

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GO Terms for genes affiliated with Alk-Positive Anaplastic Large Cell Lymphoma

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Cellular components related to Alk-Positive Anaplastic Large Cell Lymphoma according to GeneCards/GeneDecks:

idNameGO IDScoreTop Affiliating Genes
1cell cortexGO:00059389.3DVL3, DVL2

Biological processes related to Alk-Positive Anaplastic Large Cell Lymphoma according to GeneCards/GeneDecks:

(show all 11)
idNameGO IDScoreTop Affiliating Genes
1non-canonical Wnt signaling pathwayGO:00355679.6DVL3, DVL2
2convergent extensionGO:00600269.6DVL3, DVL2
3Wnt signaling pathway, planar cell polarity pathwayGO:00600719.5DVL2, DVL3
4planar cell polarity pathway involved in neural tube closureGO:00901799.5DVL3, DVL2
5cochlea morphogenesisGO:00901039.5DVL3, DVL2
6positive regulation of JUN kinase activityGO:00435079.4DVL2, DVL3
7neural tube closureGO:00018439.4SALL4, DVL2
8canonical Wnt signaling pathwayGO:00600709.3DVL3, DVL2
9positive regulation of protein phosphorylationGO:00019349.2DVL2, DVL3
10Wnt signaling pathwayGO:00160559.0DVL3, DVL2
11signal transductionGO:00071658.8ALK, IL21, EBP

Molecular functions related to Alk-Positive Anaplastic Large Cell Lymphoma according to GeneCards/GeneDecks:

idNameGO IDScoreTop Affiliating Genes
1frizzled bindingGO:00051099.3DVL3, DVL2

Products for genes affiliated with Alk-Positive Anaplastic Large Cell Lymphoma

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Sources for Alk-Positive Anaplastic Large Cell Lymphoma

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4CDC
15ExPASy
16FMA
24GTR
25HGMD
26HMDB
27ICD10
28ICD10 via Orphanet
29ICD9CM
30IUPHAR
31KEGG
35MeSH
36MESH via Orphanet
37MGI
40NCIt
41NDF-RT
44NINDS
45Novoseek
47OMIM
48OMIM via Orphanet
52PubMed
53QIAGEN
58SNOMED-CT via Orphanet
62UMLS
63UMLS via Orphanet