MCID: ALL006
MIFTS: 58

Allergic Asthma malady

Immune category

Summaries for Allergic Asthma

Sources:
8Disease Ontology, 33MalaCards
See all sources

Fully expand this MalaCard

Export this MalaCard
Disease Ontology:8 An asthma that is characterized by symptoms that are triggered by an allergic reaction caused by inhaled allergens such as dust mite allergen, pet dander, pollen and mold. allergic asthma is airway obstruction and inflammation that is partially reversible with medication. the disease has symptom coughing, has symptom wheezing, has symptom shortness of breath or has symptom rapid breathing, and has symptom chest tightness.

MalaCards: Allergic Asthma, also known as extrinsic asthma with status asthmaticus, is related to asthma and allergic rhinitis, and has symptoms including wheezing, coughing and shortness of breath or has_symptom rapid breathing. An important gene associated with Allergic Asthma is IL13 (interleukin 13), and among its related pathways are Akt Signaling and TGF-Beta Pathway. The compounds omalizumab and dexamethasone have been mentioned in the context of this disorder. Affiliated tissues include skin, liver and brain, and related mouse phenotypes are immune system and respiratory system.

Aliases & Classifications for Allergic Asthma

Sources:
8Disease Ontology, 61UMLS, 45Novoseek, 57SNOMED-CT, 27ICD9CM
See all sources

Classifications:

Malacards categories (disease lists): (See all malacards categories)
Anatomical: Immune


Aliases & Descriptions:

allergic asthma 8 61
extrinsic asthma with status asthmaticus 8
extrinsic asthma with acute exacerbation 8
asthma allergic 45


Related Diseases for Allergic Asthma

Sources:
17GeneCards, 18GeneDecks
See all sources

Diseases related to Allergic Asthma via text searches within MalaCards or GeneCards/GeneDecks gene sharing:

(show top 50)    (show all 98)
idRelated DiseaseScoreTop Affiliating Genes
1asthma32.2IGHE, RNASE3, IL13, IL5, IL4
2allergic rhinitis31.1IGHE, RNASE3, IL13, IL5, IL4
3atopic dermatitis30.5CCL18, CCL26, RNASE3, IL13, IL4, FCER1A
4urticaria30.5IGHE, RNASE3, FCER1A
5allergic bronchopulmonary aspergillosis30.5IGHE, IL5, IL4
6intrinsic asthma30.3IGHE, RNASE3, IL5, IL4
7arthritis30.3CISH, IL13, IL4
8atopy30.1RNASE3, IGHE, HAVCR1, IL13, IL5, IL4
9vernal keratoconjunctivitis30.1IL4, IL5, IL13, RNASE3, IGHE
10eosinophilic gastroenteritis30.1IL5, IGHE
11toxocariasis30.1IGHE, RNASE3
12asthma 210.5
13asthma 110.5
14allergic urticaria10.4
15h. pylori infection10.4
16hepatitis a10.2
17hepatitis c10.1
18interstitial emphysema10.1
19hepatitis e10.1
20common variable immunodeficiency10.1
21chronic rhinitis10.1
22lichen planus10.1
23n syndrome10.1
24cough variant asthma10.1
25allergic contact dermatitis10.1
26aspergillosis10.1
27wells syndrome10.1
28stachybotrys chartarum10.1
29pulmonary function10.1
30pulmonary disease, chronic obstructive10.1
31tako-tsubo cardiomyopathy10.1
32eosinophilia10.0CCL26, IGHE, RNASE3, RNASE2, IL13, IL5
33rhinitis10.0IGHE, RNASE3, MS4A2, IL4, IL5, IL13
34dermatitis10.0MS4A2, IL4, IL5, IL13, IGHE, CCL18
35rheumatoid arthritis10.0CCL18, HAVCR1, PPBP, CISH, RNASE3, IL13
36skin disease10.0CCL18, IGHE, RNASE3, IL13, IL5, IL17D
37pulmonary eosinophilia10.0IGHE, RNASE3, IL13, IL5, IL4
38allergic conjunctivitis10.0IGHE, RNASE3, IL13, IL5, IL4
39schistosomiasis10.0PPBP, IGHE, RNASE3, IL13, IL5, IL4
40psoriasis10.0CCL18, RNASE3, IL13, IL5, IL17D, IL4
41food allergy10.0IGHE, RNASE3, IL13, IL5, IL4
42bronchiolitis10.0IL5, IL13, RNASE3, IGHE
43helminthiasis10.0IGHE, RNASE3, IL13, IL5
44eosinophilic pneumonia10.0IL5, IL13, RNASE3, IGHE
45kimura disease10.0IGHE, RNASE3, IL5
46eosinophilic esophagitis10.0IL5, RNASE2, CCL26
47leukemia10.0IL4, RNASE3, CISH, PPBP
48churg-strauss syndrome10.0RNASE3, IL5
49bullous pemphigoid10.0IL5, IL13, RNASE3, IGHE
50sinusitis10.0IGHE, RNASE3, IL5

Graphical network of the top 20 diseases related to Allergic Asthma:



Diseases related to allergic asthma

Clinical Features for Allergic Asthma

Sources:
8Disease Ontology
See all sources


Symptoms:

8 (see all 4)
  • wheezing
  • coughing
  • shortness of breath or has_symptom rapid breathing
  • chest tightness

Drugs & Therapeutics for Allergic Asthma

Sources:
5CenterWatch, 42NIH Clinical Center, 6ClinicalTrials, 61UMLS, 41NDF-RT
See all sources

Approved drugs:

Search CenterWatch for Allergic Asthma

Drug clinical trials:

Search ClinicalTrials for Allergic Asthma

Search NIH Clinical Center for Allergic Asthma

Highlights from CenterWatch's Drugs in Clinical Trials Database for Allergic Asthma:

idCompanyCompoundMechanismPhase
1Rigel PharmaceuticalsR343An inhalation formulation of a small-molecule syk kinase inhibitorII

Genetic Tests for Allergic Asthma

Anatomical Context for Allergic Asthma

Sources:
33MalaCards
See all sources

MalaCards organs/tissues related to Allergic Asthma:

33
Skin, Liver, Brain, Lung, Spleen, Bone marrow, Heart, Smooth muscle, Small intestine, Colon, Breast, Myeloid, Monocytes, Nk cells, T cells, B cells, Endothelial, Bronchial epithelium

Animal Models for Allergic Asthma or affiliated genes

Sources:
37MGI, 28inGenious Targeting Laboratory
See all sources

Publications for Allergic Asthma

Sources:
51PubMed
See all sources

Articles related to Allergic Asthma:

(show top 50)    (show all 1001)
idTitleAuthorsYear
1
The activating protein 1 transcription factor basic leucine zipper transcription factor, ATF-like (BATF), regulates lymphocyte- and mast cell-driven immune responses in the setting of allergic asthma. (24290279)
2014
2
Characterization of reactive nitrogen species in allergic asthma. (24331388)
2014
3
Bone marrow mononuclear cell therapy in experimental allergic asthma: intratracheal versus intravenous administration. (23164835)
2013
4
Concomitant asthma medications in moderate-to-severe allergic asthma treated with omalizumab. (23083840)
2013
5
High-altitude sojourn: a treatment option in allergic asthma. (23897222)
2013
6
Coexistence of allergic bronchopulmonary aspergillosis and allergic aspergillus sinusitis in a patient without clinical asthma. (23645638)
2013
7
Diesel exhaust particle exposure increases severity of allergic asthma in young mice. (24112543)
2013
8
Pollen aero allergens and the climate in Mediterranean region and allergen sensitivity in allergic rhinoconjunctivitis and allergic asthma patients. (23396359)
2013
9
Perinatal antibiotic treatment affects murine microbiota, immune responses and allergic asthma. (23333861)
2013
10
Allergic asthma and omalizumab--the experience at the Centro Hospitalar da Cova da Beira. (23731772)
2013
11
Guidance for a personal target value of F(E)NO in allergic asthma: case report and theoretical example. (22793785)
2013
12
Exploring the effects of omalizumab in allergic asthma: an analysis of biomarkers in the EXTRA study. (23471469)
2013
13
Association of urinary bisphenol A concentration with allergic asthma: results from the National Health and Nutrition Examination Survey 2005-2006. (22957848)
2012
14
Non-bronchodilating mechanisms of tiotropium prevent airway hyperreactivity in a guinea-pig model of allergic asthma. (21871018)
2012
15
Adenovirus-mediated delivery of soluble ST2 attenuates ovalbumin-induced allergic asthma in mice. (22943195)
2012
16
Lipopolysaccharide enhances FcI/RI-mediated mast cell degranulation by increasing Ca2+ entry through store-operated Ca2+ channels: implications for lipopolysaccharide exacerbating allergic asthma. (22581748)
2012
17
Can anti-IgE therapy prevent airway remodeling in allergic asthma? (21645010)
2011
18
Altered expressions of helper T cell (Th)1, Th2, and Th17 cytokines in CD8(+) and I^I' T cells in patients with allergic asthma. (21492057)
2011
19
Saliva and serum eosinophil cationic protein in asthmatic children and adolescents with and without allergic sensitization. (20100023)
2010
20
Role of breast regression protein-39/YKL-40 in asthma and allergic responses. (20224674)
2010
21
Complement-mediated regulation of the IL-17A axis is a central genetic determinant of the severity of experimental allergic asthma. (20802484)
2010
22
Expression of IL-4 receptor alpha on smooth muscle cells is not necessary for development of experimental allergic asthma. (20579713)
2010
23
The value and safety of specific nasal provocation in the diagnosis of allergic rhinitis in mild persistent asthma under inhaled steroid therapy. (21038779)
2010
24
Soluble serum HLA-G in children with allergic rhinitis and asthma. (20487636)
2010
25
Systemic Toll-like receptor stimulation suppresses experimental allergic asthma and autoimmune diabetes in NOD mice. (20628601)
2010
26
Simultaneous occurrence of chronic autoimmune urticaria and non-allergic asthma: a common mechanism? (19585861)
2009
27
Link between allergic asthma and airway mucosal infection suggested by proteinase-secreting household fungi. (19710638)
2009
28
Aspergillus hypersensitivity and allergic bronchopulmonary aspergillosis in patients with bronchial asthma: systematic review and meta-analysis. (19723372)
2009
29
Effects of corticosteroids on osteopontin expression in a murine model of allergic asthma. (19494498)
2009
30
The functional insufficiency of human CD4+CD25 high T-regulatory cells in allergic asthma is subjected to TNF-alpha modulation. (18053016)
2008
31
Add-on omalizumab improves day-to-day symptoms in inadequately controlled severe persistent allergic asthma. (18355388)
2008
32
Allergic asthma and rhinitis caused by household rabbit exposure: identification of serum-specific IgE and its allergens. (17982229)
2007
33
Active immunotherapy of allergic asthma with a recombinant human interleukin-5 protein as vaccine in a murine model. (17908461)
2007
34
Autologous serum skin test reactivity in patients with non-allergic asthma. (16008669)
2005
35
Effects of allergen inhalation and oral glucocorticoid on serum soluble CTLA-4 in allergic asthmatics. (15876307)
2005
36
Uncoordinated production of Laminin-5 chains in airways epithelium of allergic asthmatics. (16179086)
2005
37
Interleukin 16 (IL-16) in asthma and allergic rhinitis. A comparison between upper and lower airways. (16734115)
2004
38
Omalizumab: a review of its use in the management of allergic asthma. (15219177)
2004
39
Omalizumab, anti-IgE recombinant humanized monoclonal antibody, for the treatment of severe allergic asthma. (11496232)
2001
40
Characterization of T cell subpopulations involved in the pathogenesis of asthma and allergic diseases. (10686504)
2000
41
The eotaxins in asthma and allergic inflammation: implications for therapy. (11249715)
2000
42
Allergic bronchopulmonary aspergillosis or bronchopulmonary aspergillosis with asthma: which one is more appropriate? (10593831)
1999
43
Interleukin-12 inhibits production of interleukin-5 but not of granulocyte/macrophage colony-stimulating factor by antigen-stimulated blood mononuclear cells in allergic bronchial asthmatics. (9430500)
1998
44
A study of granulocyte respiratory burst in patients with allergic bronchial asthma. (9484649)
1998
45
Interleukin-13: central mediator of allergic asthma. (9856949)
1998
46
Role of interleukin-4 and vascular cell adhesion molecule-1 in selective eosinophil migration into the airways in allergic asthma. (8534490)
1996
47
Inflammation mediators (eosinophilic cationic protein, ECP) in a normal population and in patients with bronchial asthma or allergic rhinitis]. (7627423)
1995
48
Eosinophils express interleukin 5 and granulocyte macrophage-colony-stimulating factor mRNA at sites of allergic inflammation in asthmatics. (1401075)
1992
49
A clinical investigation of the role of allergic factors in the severity of bronchial asthma]. (1793363)
1991
50
Allergic bronchopulmonary aspergillosis in asthmatic patients presenting with allergic rhinitis. (3949407)
1986

Genetic Variations for Allergic Asthma

Expression for genes affiliated with Allergic Asthma

Sources:
1BioGPS, 15Gene Expression Omnibus DataSets
See all sources
Expression patterns in normal tissues for genes affiliated with Allergic Asthma

Search GEO for disease gene expression data for Allergic Asthma.

Pathways for genes affiliated with Allergic Asthma

Sources:
52QIAGEN, 30KEGG, 12EMD Millipore, 38NCBI BioSystems Database, 53R&D Systems, 54Reactome
See all sources

Pathways related to Allergic Asthma according to GeneCards/GeneDecks:

(show all 19)
idSuper pathways (with members indented)ScoreTop Affiliating Genes
1
Hide members
10.7CCL26, CCL25, CCL18, PPBP, IL13, IL5
2
Hide members
10.7CCL26, CCL25, CCL18, PPBP, CISH, IL13
3
Hide members
10.7FCER1A, CCL26, CCL25, CCL18, PPBP, IL13
4
Hide members
10.7CCL26, CCL25, CCL18, PPBP, IL13, IL5
5
Hide members
10.7CCL26, CCL25, CCL18, PPBP, IL13, IL5
6
Hide members
10.7IGHE, IL13, IL5, IL4, FCER1A, MS4A2
7
Hide members
10.6CCL25, RNASE3, IL13, IL5, IL4
810.6TBX21, IL13, IL5, IL4
9
Hide members
10.6TBX21, IL13, IL5, IL4
1010.6IL4, IL5, IL13, CISH
1110.6CCL26, IGHE, IL5, IL4
1210.6IL13, IL5, IL4
1310.6IL4, IL5, IL13
1410.6IL4, IL5, IL13
15
Hide members
10.6CCL26, CCL25, CCL18, PPBP
16
Hide members
10.6IL4, IL5, TBX21
17
Hide members
10.6MS4A2, FCER1A, IGHE
18
Immune response NFAT in immune response
Hide members
10.6IGHE, FCER1A, MS4A2
1910.5FCER1A, IL4

Compounds for genes affiliated with Allergic Asthma

Sources:
45Novoseek, 11DrugBank, 50PharmGKB, 29IUPHAR, 24HMDB, 60Tocris Bioscience, 2BitterDB
See all sources

Compounds related to Allergic Asthma according to GeneCards/GeneDecks:

(show top 50)    (show all 80)
idCompoundScoreTop Affiliating Genes
1omalizumab45 1112.1MS4A2, FCER1A, IL4, IL5, IL13, IGHE
2dexamethasone45 50 29 1114.1CCL18, PPBP, CISH, IGHE, RNASE3, IL13
3allergens4511.1IGHE, RNASE3, IL13, IL5, IL4, MS4A2
4histamine45 29 2413.1PPBP, IGHE, RNASE3, IL13, IL5, IL4
5tarc4511.1CCL26, CCL18, IGHE, IL13, IL5, IL4
6praziquantel45 1112.1IGHE, RNASE3, IL13, IL5, IL4
7montelukast45 50 29 1114.1IGHE, RNASE3, IL13, IL5, IL4
8budesonide45 50 1113.1IGHE, RNASE3, IL13, IL5, IL4
9fluticasone propionate45 50 60 1114.1IGHE, RNASE3, IL13, IL5, IL4
10methacholine45 1112.1IGHE, RNASE3, IL13, IL5, IL4
11salmeterol45 50 29 1114.0IL4, IL5, IL13, RNASE3
12nedocromil sodium4511.0IL4, IL5, RNASE3, IGHE
13azelastine45 1112.0IGHE, RNASE3, IL5, IL4
14penicillin4511.0IL5, IL13, IGHE, PPBP
15vegf4511.0CCL18, PPBP, IGHE, RNASE3, IL13, IL5
16rantes4511.0PPBP, RNASE3, IL4
17salbutamol45 50 29 11 2415.0IGHE, RNASE3, IL13, IL5
18pgd24511.0IL5, IL13, RNASE3, IGHE
19unicap4511.0IL5, RNASE3, IGHE
20aspirin45 50 29 2414.0PPBP, TFF2, RNASE3, IL13, IL4
21beclomethasone dipropionate4511.0IGHE, RNASE3, IL5
22capsaicin45 2912.0TFF2, IGHE, RNASE3, IL5
23sodium cromoglycate4511.0IGHE, RNASE3, IL5
24toluene diisocyanate4511.0IGHE, RNASE3, IL5
25desloratadine45 1111.9IGHE, IL13, IL4
26formoterol45 29 1112.9RNASE3, IL13, IL4
27ovomucoid4510.9IGHE
28cetirizine45 29 11 2413.9IL5, RNASE3, IGHE
29pranlukast45 29 1112.9IL4, IL5, RNASE3
30glatiramer acetate45 1111.9IL13, IL5, IL4
31ketotifen45 1111.9IL5, RNASE3, IGHE
32indomethacin45 60 29 1113.9TFF2, IGHE, IL13, IL5, IL4
33itraconazole45 1111.9IGHE, IL5, IL4
34amphotericin b4510.9IL13, IL5, IL4
35leukotriene b445 60 2412.9PPBP, RNASE3, IL13, IL5
36ltd44510.9RNASE3, IL13, IL5
37il-124510.9IL4, IL5, IL13
38prednisolone45 29 1112.9IGHE, RNASE3, IL13, IL5
39trimellitic anhydride4510.8IL13, IGHE
40ltc44510.8RNASE3, IL13, IL5
41hydrocortisone45 2 60 1113.7IGHE
42Adenosine-2'-5'-Diphosphate1110.7RNASE3, RNASE2
43methyltetrahydrophthalic anhydride4510.7IGHE, IL13
44tolnaftate4510.7IL5, IL4
45loteprednol45 1111.7IL5, IL4
46oxazolone4510.6IL13, IL4
47thyroxine45 2411.6IGHE, IL13, IL5, IL4
48fmlp4510.6IL5, IL13, RNASE3, PPBP
49mometasone45 1111.4IL4, IL5
50isoproterenol45 1111.2IL5

GO Terms for genes affiliated with Allergic Asthma

Sources:
16Gene Ontology
See all sources

Cellular components related to Allergic Asthma according to GeneCards/GeneDecks:

idNameGO IDScoreTop Affiliating Genes
1extracellular spaceGO:00561510.7SERPINB4, CCL26, CCL25, CCL18, PPBP, TFF2
2external side of plasma membraneGO:00989710.6MS4A2, FCER1A, IL4, IL13
3extracellular regionGO:00557610.4CCL25, GZMK, PPBP, IGHE, RNASE3, RNASE2

Biological processes related to Allergic Asthma according to GeneCards/GeneDecks:

(show all 9)
idNameGO IDScoreTop Affiliating Genes
1immune responseGO:00695510.9SERPINB4, CCL26, CCL25, CCL18, IGHE, IL13
2inflammatory responseGO:00695410.8CCL26, CCL25, CCL18, IL13, IL5, IL17D
3chemotaxisGO:00693510.8CCL26, CCL25, CCL18, RNASE2, IL4
4positive regulation of B cell proliferationGO:03089010.7IL4, IL5, IL13
5regulation of proton transportGO:01015510.6IL4, IL13
6positive regulation of isotype switching to IgG isotypesGO:04830410.5TBX21, IL4
7RNA catabolic processGO:00640110.5RNASE2, RNASE3
8negative regulation of macrophage activationGO:04303110.4TFF2, IL4
9positive regulation of mast cell degranulationGO:04330610.2MS4A2, FCER1A

Molecular functions related to Allergic Asthma according to GeneCards/GeneDecks:

idNameGO IDScoreTop Affiliating Genes
1chemokine activityGO:00800910.6PPBP, CCL18, CCL25, CCL26
2cytokine activityGO:00512510.6IL13, IL25, IL5, IL17D, IL4
3pancreatic ribonuclease activityGO:00452210.5RNASE2, RNASE3
4IgE bindingGO:01986310.4MS4A2, FCER1A
5ribonuclease activityGO:00454010.2RNASE2, RNASE3

Products for genes affiliated with Allergic Asthma

  • Antibodies
  • Proteins
  • Lysates
  • Antibodies

Sources for Allergic Asthma

3CDC
13ExPASy
14FMA
22GTR
23HGMD
24HMDB
25ICD10
26ICD10 via Orphanet
27ICD9CM
29IUPHAR
30KEGG
35MeSH
36MESH via Orphanet
37MGI
40NCIt
41NDF-RT
44NINDS
45Novoseek
47OMIM
48OMIM via Orphanet
51PubMed
52QIAGEN
58SNOMED-CT via Orphanet
61UMLS
62UMLS via Orphanet