MCID: ALL006
MIFTS: 60

Allergic Asthma malady

Immune diseases category

Summaries for Allergic Asthma

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8Disease Ontology, 32MalaCards
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Disease Ontology:8 An asthma that is characterized by symptoms that are triggered by an allergic reaction caused by inhaled allergens such as dust mite allergen, pet dander, pollen and mold. allergic asthma is airway obstruction and inflammation that is partially reversible with medication. the disease has symptom coughing, has symptom wheezing, has symptom shortness of breath or has symptom rapid breathing, and has symptom chest tightness.

MalaCards: Allergic Asthma, also known as extrinsic asthma with status asthmaticus, is related to asthma and rhinitis, and has symptoms including chest tightness, shortness of breath or has_symptom rapid breathing and wheezing. An important gene associated with Allergic Asthma is IL13 (interleukin 13), and among its related pathways are Akt Signaling and TGF-Beta Pathway. The compounds omalizumab and dexamethasone have been mentioned in the context of this disorder. Affiliated tissues include t cells, lung and testes, and related mouse phenotypes are immune system and respiratory system.

Aliases & Classifications for Allergic Asthma

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Sources:
8Disease Ontology, 60UMLS, 44Novoseek, 56SNOMED-CT, 27ICD9CM
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Classifications:

Malacards categories (disease lists): (See all malacards categories)
Anatomical: Immune diseases


Aliases & Descriptions:

allergic asthma 8 60
extrinsic asthma with status asthmaticus 8
extrinsic asthma with acute exacerbation 8
asthma allergic 44


Related Diseases for Allergic Asthma

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Sources:
17GeneCards, 18GeneDecks
See all sources

Diseases related to Allergic Asthma via text searches within MalaCards or GeneCards/GeneDecks gene sharing:

(show top 50)    (show all 96)
idRelated DiseaseScoreTop Affiliating Genes
1asthma32.1IL4, IGHE, RNASE3, IL13, IL5
2rhinitis31.1IGHE, RNASE3, IL13, IL5, IL4, MS4A2
3allergic rhinitis31.1IL4, IL5, IL13, RNASE3, IGHE
4eosinophilia30.8IGHE, RNASE2, IL13, RNASE3, IL4, CCL26
5dermatitis30.6IL4, MS4A2, IL5, CCL18, IGHE, IL13
6atopic dermatitis30.5IL5, IL13, RNASE3, IL17D, MS4A2, IL4
7urticaria30.5IGHE, RNASE3, FCER1A
8allergic bronchopulmonary aspergillosis30.5IL5, IL4, IGHE
9pulmonary eosinophilia30.4IL4, IGHE, IL5, IL13, RNASE3
10rheumatoid arthritis30.3RNASE3, HAVCR1, PPBP, IL13, IL4, CCL18
11intrinsic asthma30.3IL4, IL5, RNASE3, IGHE
12arthritis30.3IL13, CISH, IL4
13hepatitis30.3HAVCR1
14skin disease30.0IL4, IL5, IL13, RNASE3, IGHE, CCL18
15food allergy30.0IL4, RNASE3, IL13, IGHE, IL5
16keratoconjunctivitis30.0IL5, RNASE3, IL13
17eosinophilic gastroenteritis30.0IGHE, IL5
18pulmonary fibrosis30.0CCL18, IL13
19pneumonia30.0IL13, CCL18, IL5
20toxocariasis30.0IGHE, RNASE3
21contact dermatitis30.0IL5, IGHE
22allergic urticaria10.3
23obesity10.3
24hepatitis a10.2
25hepatitis c10.0
26interstitial emphysema10.0
27common variable immunodeficiency10.0
28chronic rhinitis10.0
29lichen planus10.0
30cough variant asthma10.0
31allergic contact dermatitis10.0
32aspergillosis10.0
33congestive heart failure10.0
34gastroenteritis10.0
35hypertension10.0
36influenza10.0
37ischemia10.0
38periodontitis10.0
39pulmonary emphysema10.0
40atopy10.0HAVCR1, IGHE, RNASE3, IL13, IL5, IL4
41allergic conjunctivitis10.0IGHE, RNASE3, IL13, IL4, IL5
42bronchiolitis10.0RNASE3, IL13, IL5, IGHE
43schistosomiasis10.0IL4, IGHE, IL5, IL13, PPBP, RNASE3
44psoriasis10.0IL17D, IL5, IL13, RNASE3, CCL18, IL4
45vernal keratoconjunctivitis10.0IL4, IL5, IL13, RNASE3, IGHE
46helminthiasis10.0IGHE, RNASE3, IL13, IL5
47eosinophilic pneumonia10.0IL5, RNASE3, IGHE, IL13
48kimura disease10.0IL5, RNASE3, IGHE
49eosinophilic esophagitis10.0CCL26, IL5, RNASE2
50leukemia10.0CISH, PPBP, RNASE3, IL4

Graphical network of the top 20 diseases related to Allergic Asthma:



Diseases related to allergic asthma

Clinical Features for Allergic Asthma

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Sources:
8Disease Ontology
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Symptoms:

8
  • chest tightness
  • shortness of breath or has_symptom rapid breathing
  • wheezing
  • coughing

Drugs & Therapeutics for Allergic Asthma

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Sources:
5CenterWatch, 41NIH Clinical Center, 6ClinicalTrials, 60UMLS, 40NDF-RT
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Approved drugs:

Search CenterWatch for Allergic Asthma

Drug clinical trials:

Search ClinicalTrials for Allergic Asthma

Search NIH Clinical Center for Allergic Asthma

Highlights from CenterWatch's Drugs in Clinical Trials Database for Allergic Asthma:

idCompanyCompoundMechanismPhase
1Rigel PharmaceuticalsR343An inhalation formulation of a small-molecule syk kinase inhibitorII

Genetic Tests for Allergic Asthma

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Anatomical Context for Allergic Asthma

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Sources:
32MalaCards
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MalaCards organs/tissues related to Allergic Asthma:

32
T cells, Lung, Testes, Skin, Smooth muscle, Monocytes, Bone, Breast, Heart, Myeloid, Bone marrow, B cells, Endothelial, Liver, Colon, Spleen, Nk cells

Animal Models for Allergic Asthma or affiliated genes

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36MGI
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MGI Mouse Phenotypes related to Allergic Asthma:

36
idDescriptionMGI Source AccessionScoreTop Affiliating Genes
1MP:000538710.8MS4A2, CCL25, HAVCR1, TFF2, TBX21, IGHE
2MP:000538810.7IL4, IL5, IL25, IL13, TBX21, HAVCR1
3MP:000539710.6CCL25, HAVCR1, TBX21, IGHE, IL13, IL25
4MP:000538110.4CCL25, TFF2, TBX21, IL13, IL25, IL5

Publications for Allergic Asthma

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Sources:
50PubMed
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Articles related to Allergic Asthma:

(show top 50)    (show all 931)
idTitleAuthorsYear
1
A cross sectional assessment of allergic rhinitis and asthma control at an Immunoallergology outpatient hospital setting using CARAT10 questionnaire. (23643637)
2013
2
The natural course of eczema from birth to age 7 years and the association with asthma and allergic rhinitis: a population-based birth cohort study. (23406940)
2013
3
NOD-like receptors mediated activation of eosinophils interacting with bronchial epithelial cells: a link between innate immunity and allergic asthma. (23524653)
2013
4
D-dimer levels decreased in severe allergic asthma and chronic urticaria patients with the omalizumab treatment. (24359555)
2013
5
Effect of inhaled corticosteroids on long-term growth in pediatric patients with asthma and allergic rhinitis. (24259733)
2013
6
Prevalence of asthma and severity of allergic rhinitis comparing 2 perennial allergens: house dust mites and Parietaria judaica pollen. (23967752)
2013
7
Global burden of allergic bronchopulmonary aspergillosis with asthma and its complication chronic pulmonary aspergillosis in adults. (23210682)
2013
8
Influences of the microbiome on the early origins of allergic asthma. (24313768)
2013
9
Clara cells drive eosinophil accumulation in allergic asthma. (21828027)
2012
10
The two faces of mast cells in food allergy and allergic asthma: the possible concept of Yin Yang. (21757003)
2012
11
Tiarellic acid attenuates airway hyperresponsiveness and inflammation in a murine model of allergic asthma. (22085848)
2012
12
Th17 cell frequency in peripheral blood from children with allergic asthma correlates with the level of asthma control. (22944005)
2012
13
Exposure to particulate hexavalent chromium exacerbates allergic asthma pathology. (22178736)
2012
14
Anti-malarial drug artesunate ameliorates oxidative lung damage in experimental allergic asthma. (22634146)
2012
15
Regulatory T cells in allergic asthma. (22675860)
2012
16
Anti-inflammatory effects of ivermectin in mouse model of allergic asthma. (21279416)
2011
17
Role of PD-L1 and PD-L2 in allergic diseases and asthma. (20722638)
2011
18
Increased expression of aryl hydrocarbon receptor and interleukin 22 in patients with allergic asthma. (22053597)
2011
19
Can anti-IgE therapy prevent airway remodeling in allergic asthma? (21645010)
2011
20
Airway inflammation and eotaxin in exhaled breath condensate of patients with severe persistent allergic asthma during omalizumab therapy. (21940268)
2011
21
Epigenetic changes in B lymphocytes associated with house dust mite allergic asthma. (21975512)
2011
22
Dietary lycopene supplementation suppresses Th2 responses and lung eosinophilia in a mouse model of allergic asthma. (20392623)
2011
23
Oxidative stress status and plasma trace elements in patients with asthma or allergic rhinitis. (21550164)
2011
24
Serum amyloid A activates the NLRP3 inflammasome and promotes Th17 allergic asthma in mice. (21622869)
2011
25
The role of costimulatory molecules in allergic disease and asthma. (19786798)
2010
26
The absence of the VPAC(2) receptor does not protect mice from Aspergillus induced allergic asthma. (20226823)
2010
27
Effect of pretreatment with omalizumab on the tolerability of specific immunotherapy in allergic asthma. (20159249)
2010
28
Expression of survivin in lung eosinophils is associated with pathology in a mouse model of allergic asthma. (19395375)
2009
29
Esculetin restores mitochondrial dysfunction and reduces allergic asthma features in experimental murine model. (19570833)
2009
30
Soluble interleukin-10 and transforming growth factor-beta in children with acute exacerbation of allergic asthma. (19191132)
2009
31
Arginase: a key enzyme in the pathophysiology of allergic asthma opening novel therapeutic perspectives. (19703164)
2009
32
Thrombomodulin: a novel player in allergic asthma. (19251314)
2009
33
The role of interleukin-18 in the pathogenesis of bronchial asthma and other allergic diseases and in activation of basophils and mastocytes]. (19173192)
2008
34
Study on relationship between polymorphism sites of TIM4 and allergic asthma in the population of Han nationality from Hubei province of China]. (17407086)
2007
35
Galectin-9 inhibits CD44-hyaluronan interaction and suppresses a murine model of allergic asthma. (17446336)
2007
36
Allergic asthma and rhinitis caused by household rabbit exposure: identification of serum-specific IgE and its allergens. (17982229)
2007
37
Association between the polymorphisms of IL-4 gene promoter (-590C>T), IL-13 coding region (R130Q) and IL-16 gene promoter (-295T>C) and allergic asthma. (17303923)
2007
38
Study on relationship between polymorphism sites of TIM-3 and allergic asthma in a population of adult Hans from Hubei province of China]. (16456792)
2006
39
Parental tobacco smoking is associated with augmented IL-13 secretion in children with allergic asthma. (16387591)
2006
40
Relation between IgE levels and infections in patients with allergic rhinitis and asthma]. (16568707)
2005
41
CC chemokine receptors CCR1 and CCR4 are expressed on airway mast cells in allergic asthma. (16337476)
2005
42
The inverse association of salmonellosis in infancy with allergic rhinoconjunctivitis and asthma at school-age: a longitudinal study. (15813807)
2005
43
Exploring the possibility of a relationship between polymorphism in TIM-1 and allergic asthma in children of the Hans from Hubei province of China]. (15300647)
2004
44
Surface expression of Fc epsilon RI on Langerhans' cells of clinically uninvolved skin is associated with disease activity in atopic dermatitis, allergic asthma, and rhinitis. (12897750)
2003
45
Polymorphism 4G/5G in the plasminogen activator inhibitor-1 (PAI-1) gene is associated with IgE-mediated allergic diseases and asthma in the Czech population. (11972486)
2002
46
Allergic bronchopulmonary aspergillosis in the asthma clinic. A prospective evaluation of CT in the diagnostic algorithm. (10893361)
2000
47
Enhanced cytokine generation by peripheral blood mononuclear cells in allergic and asthma subjects. (10982218)
2000
48
Immunohistochemical characterization of the cellular infiltrate in airway mucosa of toluene diisocyanate (TDI)-induced asthma: comparison with allergic asthma. (9539314)
1998
49
Serum eosinophil cationic protein (ECP) levels in patients with seasonal allergic rhinitis and allergic asthma. (9578914)
1998
50
A clinical investigation of the role of allergic factors in the severity of bronchial asthma]. (1793363)
1991

Genetic Variations for Allergic Asthma

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Expression for genes affiliated with Allergic Asthma

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Sources:
1BioGPS, 15Gene Expression Omnibus DataSets
See all sources
Expression patterns in normal tissues for genes affiliated with Allergic Asthma

Search GEO for disease gene expression data for Allergic Asthma.

Pathways for genes affiliated with Allergic Asthma

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Sources:
51QIAGEN, 29KEGG, 12EMD Millipore, 37NCBI BioSystems Database, 52R&D Systems, 53Reactome
See all sources

Pathways related to Allergic Asthma according to GeneCards/GeneDecks:

(show all 19)
idSuper pathways (with members indented)ScoreTop Affiliating Genes
1
Hide members
10.7CCL26, CCL25, CCL18, PPBP, IL13, IL5
2
Hide members
10.7CCL26, CCL25, CCL18, PPBP, CISH, IL13
3
Hide members
10.7FCER1A, CCL26, CCL25, CCL18, PPBP, IL13
4
Hide members
10.7CCL26, CCL25, CCL18, PPBP, IL13, IL5
5
Hide members
10.7CCL26, CCL25, CCL18, PPBP, IL13, IL5
6
Hide members
10.7IGHE, IL13, IL5, IL4, FCER1A, MS4A2
7
Hide members
10.6CCL25, RNASE3, IL13, IL5, IL4
810.6TBX21, IL13, IL5, IL4
9
Hide members
10.6TBX21, IL13, IL5, IL4
1010.6IL4, IL5, IL13, CISH
1110.6CCL26, IGHE, IL5, IL4
1210.6IL13, IL5, IL4
1310.6IL4, IL5, IL13
1410.6IL4, IL5, IL13
15
Hide members
10.6CCL26, CCL25, CCL18, PPBP
16
Hide members
10.6IL4, IL5, TBX21
17
Hide members
10.6MS4A2, FCER1A, IGHE
18
Immune response NFAT in immune response
Hide members
10.6IGHE, FCER1A, MS4A2
1910.5FCER1A, IL4

Compounds for genes affiliated with Allergic Asthma

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Sources:
44Novoseek, 11DrugBank, 49PharmGKB, 28IUPHAR, 24HMDB, 59Tocris Bioscience, 2BitterDB
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Compounds related to Allergic Asthma according to GeneCards/GeneDecks:

(show top 50)    (show all 80)
idCompoundScoreTop Affiliating Genes
1omalizumab44 1112.1IGHE, MS4A2, IL4, FCER1A, IL5, IL13
2dexamethasone44 49 28 1114.1CISH, PPBP, CCL18, IGHE, IL13, IL5
3allergens4411.1IGHE, RNASE3, IL13, IL5, IL4, MS4A2
4histamine44 28 2413.1IL4, IGHE, RNASE3, IL5, FCER1A, PPBP
5tarc4411.1CCL26, IL4, IL5, IL13, IGHE, CCL18
6praziquantel44 1112.1IL5, IL13, RNASE3, IGHE, IL4
7montelukast44 49 28 1114.1RNASE3, IL4, IL5, IL13, IGHE
8budesonide44 49 1113.1RNASE3, IGHE, IL13, IL5, IL4
9fluticasone propionate44 49 59 1114.1IL4, IL5, IL13, RNASE3, IGHE
10methacholine44 1112.1IGHE, IL13, IL5, IL4, RNASE3
11salmeterol44 49 28 1114.0IL5, IL13, RNASE3, IL4
12nedocromil sodium4411.0IL5, RNASE3, IGHE, IL4
13azelastine44 1112.0IL4, IL5, RNASE3, IGHE
14penicillin4411.0PPBP, IGHE, IL5, IL13
15vegf4411.0IL4, IL5, IL13, CCL18, RNASE3, IGHE
16rantes4411.0PPBP, RNASE3, IL4
17salbutamol44 49 28 11 2415.0IGHE, RNASE3, IL5, IL13
18pgd24411.0IGHE, IL5, RNASE3, IL13
19unicap4411.0IGHE, IL5, RNASE3
20aspirin44 49 28 2414.0IL4, IL13, RNASE3, TFF2, PPBP
21beclomethasone dipropionate4411.0RNASE3, IGHE, IL5
22capsaicin44 2812.0RNASE3, IL5, TFF2, IGHE
23toluene diisocyanate4411.0IL5, IGHE, RNASE3
24sodium cromoglycate4411.0IL5, RNASE3, IGHE
25desloratadine44 1111.9IGHE, IL13, IL4
26formoterol44 28 1112.9IL4, RNASE3, IL13
27ovomucoid4410.9IGHE
28cetirizine44 28 11 2413.9RNASE3, IL5, IGHE
29pranlukast44 28 1112.9RNASE3, IL5, IL4
30glatiramer acetate44 1111.9IL4, IL5, IL13
31ketotifen44 1111.9IL5, RNASE3, IGHE
32indomethacin44 59 28 1113.9TFF2, IGHE, IL13, IL5, IL4
33itraconazole44 1111.9IGHE, IL5, IL4
34amphotericin b4410.9IL13, IL4, IL5
35leukotriene b444 59 2412.9IL13, IL5, PPBP, RNASE3
36ltd44410.9IL13, RNASE3, IL5
37il-124410.9IL4, IL5, IL13
38prednisolone44 28 1112.9IGHE, RNASE3, IL5, IL13
39trimellitic anhydride4410.8IGHE, IL13
40ltc44410.8RNASE3, IL13, IL5
41hydrocortisone44 2 59 1113.7IGHE
42loteprednol44 1111.7IL4, IL5
43oxazolone4410.7IL13, IL4
44Adenosine-2'-5'-Diphosphate1110.7RNASE3, RNASE2
45tolnaftate4410.7IL4, IL5
46methyltetrahydrophthalic anhydride4410.6IL13, IGHE
47thyroxine44 2411.6IL13, IL4, IL5, IGHE
48fmlp4410.6IL13, IL5, PPBP, RNASE3
49mometasone44 1111.4IL4, IL5
50isoproterenol44 1111.2IL5

GO Terms for genes affiliated with Allergic Asthma

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Sources:
16Gene Ontology
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Cellular components related to Allergic Asthma according to GeneCards/GeneDecks:

idNameGO IDScoreTop Affiliating Genes
1extracellular spaceGO:00561510.7SERPINB4, CCL26, CCL25, CCL18, PPBP, TFF2
2external side of plasma membraneGO:00989710.6MS4A2, FCER1A, IL4, IL13
3extracellular regionGO:00557610.4CCL25, GZMK, PPBP, IGHE, RNASE3, RNASE2

Biological processes related to Allergic Asthma according to GeneCards/GeneDecks:

(show all 9)
idNameGO IDScoreTop Affiliating Genes
1immune responseGO:00695510.9SERPINB4, CCL26, CCL25, CCL18, IGHE, IL13
2inflammatory responseGO:00695410.8CCL26, CCL25, CCL18, IL13, IL5, IL17D
3chemotaxisGO:00693510.8CCL26, CCL25, CCL18, RNASE2, IL4
4positive regulation of B cell proliferationGO:03089010.7IL4, IL5, IL13
5regulation of proton transportGO:01015510.6IL4, IL13
6positive regulation of isotype switching to IgG isotypesGO:04830410.5TBX21, IL4
7RNA catabolic processGO:00640110.5RNASE2, RNASE3
8negative regulation of macrophage activationGO:04303110.4TFF2, IL4
9positive regulation of mast cell degranulationGO:04330610.2MS4A2, FCER1A

Molecular functions related to Allergic Asthma according to GeneCards/GeneDecks:

idNameGO IDScoreTop Affiliating Genes
1chemokine activityGO:00800910.6PPBP, CCL18, CCL25, CCL26
2cytokine activityGO:00512510.6IL13, IL25, IL5, IL17D, IL4
3pancreatic ribonuclease activityGO:00452210.5RNASE2, RNASE3
4IgE bindingGO:01986310.4MS4A2, FCER1A
5ribonuclease activityGO:00454010.2RNASE2, RNASE3

Products for genes affiliated with Allergic Asthma

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  • Antibodies
  • Proteins
  • Lysates
  • Antibodies

Sources for Allergic Asthma

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3CDC
13ExPASy
14FMA
22GTR
23HGMD
24HMDB
25ICD10
26ICD10 via Orphanet
27ICD9CM
28IUPHAR
29KEGG
34MeSH
35MESH via Orphanet
36MGI
39NCIt
40NDF-RT
43NINDS
44Novoseek
46OMIM
47OMIM via Orphanet
50PubMed
51QIAGEN
57SNOMED-CT via Orphanet
60UMLS
61UMLS via Orphanet