MCID: ALL006
MIFTS: 46

Allergic Asthma malady

Immune diseases category

Summaries for Allergic Asthma

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Disease Ontology:9 An asthma that is characterized by symptoms that are triggered by an allergic reaction caused by inhaled allergens such as dust mite allergen, pet dander, pollen and mold. allergic asthma is airway obstruction and inflammation that is partially reversible with medication. the disease has symptom coughing, has symptom wheezing, has symptom shortness of breath or has symptom rapid breathing, and has symptom chest tightness.

MalaCards based summary: Allergic Asthma, also known as extrinsic asthma with status asthmaticus, is related to asthma and rhinitis, and has symptoms including coughing, wheezing and shortness of breath or has_symptom rapid breathing. An important gene associated with Allergic Asthma is IL13 (interleukin 13), and among its related pathways are IL12 signaling mediated by STAT4 and PI-3K cascade. The compounds scca1 and trimellitic anhydride have been mentioned in the context of this disorder. Affiliated tissues include t cells, lung and neutrophil, and related mouse phenotypes are immune system and hematopoietic system.

Aliases & Classifications for Allergic Asthma

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Allergic Asthma, Aliases & Descriptions:

Name: Allergic Asthma 9 60
Extrinsic Asthma with Status Asthmaticus 9 60
 
Extrinsic Asthma with Acute Exacerbation 9
Asthma Allergic 43


Classifications:

Malacards categories (disease lists): (See all malacards categories)
Anatomical: Immune diseases


Related Diseases for Allergic Asthma

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Diseases related to Allergic Asthma via text searches within MalaCards or GeneCards Suite gene sharing:

(show top 50)    (show all 54)
idRelated DiseaseScoreTop Affiliating Genes
1asthma32.8IGHE, IL13
2rhinitis31.5IL13, IGHE, MS4A2
3allergic rhinitis31.4IL13, IGHE
4pulmonary eosinophilia31.0IL13, IGHE
5urticaria30.8FCER1A, IGHE
6dermatitis30.7CCL27, IGHE, IL13
7food allergy30.6IGHE, IL13
8eosinophilia30.6IGHE, CCL24, CCL27, IL13
9atopy30.4IL13, IGHE, MS4A2
10vernal keratoconjunctivitis30.3IGHE, CCL24, IL13
11atopic dermatitis30.0IGHE, MS4A2, CCL18, IL13, CCL27
12allergic bronchopulmonary aspergillosis10.5
13obesity10.4
14blindness10.4
15parasitic helminthiasis infectious disease10.4IL13, IGHE
16allergic conjunctivitis10.4IGHE, IL13
17conjunctivitis10.3IGHE, MS4A2
18eosinophilic pneumonia10.3IGHE, IL13
19filariasis10.3IL13, IGHE
20mastocytosis10.3IGHE, IL13
21bronchiolitis10.3IL13, IGHE
22respiratory failure10.3IGHE, IL13
23schistosomiasis10.2IL13, IGHE
24rheumatoid arthritis10.2
25arthritis10.2
26hepatitis10.2
27bullous pemphigoid10.2IL13, IGHE
28pulmonary function10.1
29aspergillosis10.1
30common variable immunodeficiency10.1
31congestive heart failure10.1
32pulmonary fibrosis10.1
33sinusitis10.1
34hepatitis c10.1
35lichen planus10.1
36intrinsic asthma10.1
37eosinophilic gastroenteritis10.1
38toxocariasis10.1
39hepatitis a10.1
40congenital heart disease10.1
41contact dermatitis10.1
42gastroenteritis10.1
43influenza10.1
44ischemia10.1
45keratoconjunctivitis10.1
46periodontitis10.1
47pneumonia10.1
48stachybotrys chartarum10.1
49wells syndrome10.1
50endotheliitis10.1

Graphical network of the top 20 diseases related to Allergic Asthma:



Diseases related to allergic asthma

Symptoms for Allergic Asthma

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Symptoms:

 9
  • coughing
  • wheezing
  • shortness of breath or has_symptom rapid breathing
  • chest tightness

Drugs & Therapeutics for Allergic Asthma

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Drug clinical trials:

Search ClinicalTrials for Allergic Asthma

Search NIH Clinical Center for Allergic Asthma

Genetic Tests for Allergic Asthma

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Anatomical Context for Allergic Asthma

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MalaCards organs/tissues related to Allergic Asthma:

31
T cells, Lung, Neutrophil, Smooth muscle, Skin, Testes, Bone, Monocytes, B cells, Heart, Breast, Myeloid, Bone marrow, Spleen, Endothelial

Animal Models for Allergic Asthma or affiliated genes

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MGI Mouse Phenotypes related to Allergic Asthma:

35
idDescriptionMGI Source AccessionScoreTop Affiliating Genes
1MP:00053877.5IGHE, FCER1A, MS4A2, CCL24, CCL25, IL25
2MP:00053977.2IGHE, FCER1A, MS4A2, CCL24, CCL25, IL25

Publications for Allergic Asthma

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Articles related to Allergic Asthma:

(show top 50)    (show all 670)
idTitleAuthorsYear
1
Childhood allergic asthma is associated with increased IL-13 and FOXP3 histone acetylation. (25769912)
2015
2
Calcium-sensing receptor antagonists abrogate airway hyperresponsiveness and inflammation in allergic asthma. (25904744)
2015
3
Expression and targeting of lymphocyte function-associated antigen 1 (LFA-1) on white blood cells for treatment of allergic asthma. (25341726)
2014
4
Reprint of: Perinatal and early childhood environmental factors influencing allergic asthma immunopathogenesis. (25308874)
2014
5
Effects of taraxasterol on ovalbumin-induced allergic asthma in mice. (23727181)
2013
6
Roles of histone hypoacetylation in LAT expression on T cells and Th2 polarization in allergic asthma. (23360572)
2013
7
Anaphylatoxins coordinate innate and adaptive immune responses in allergic asthma. (23694705)
2013
8
Bone marrow mononuclear cell therapy in experimental allergic asthma: intratracheal versus intravenous administration. (23164835)
2013
9
Experimental model of allergic asthma. (22836618)
2013
10
The eXpeRience registry: the 'real-world' effectiveness of omalizumab in allergic asthma. (23721684)
2013
11
Concomitant asthma medications in moderate-to-severe allergic asthma treated with omalizumab. (23083840)
2013
12
Anti-asthmatic Effects of Baicalin in a Mouse Model of Allergic Asthma. (23580257)
2013
13
Phenotypic characterization of ex vivo CD4+CD25highCD127low immune regulatory T cells in allergic asthma: pathogenesis relevance of their FoxP3, GITR, CTLA-4 and FAS expressions. (23241113)
2012
14
The single nucleotide polymorphism CRTh2 rs533116 is associated with allergic asthma and increased expression of CRTh2. (22947041)
2012
15
The effects of (A+)-Praeruptorin A on airway inflammation, remodeling and transforming growth factor-I^1/Smad signaling pathway in a murine model of allergic asthma. (22974581)
2012
16
Crude extracts of Caenorhabditis elegans suppress airway inflammation in a murine model of allergic asthma. (22558152)
2012
17
Association of allergic asthma emergency room visits with the main biological and chemical air pollutants. (22750174)
2012
18
Low frequency of CD8+CD25+FOXP3(BRIGHT) T cells and FOXP3 mRNA expression in the peripheral blood of allergic asthma patients. (22824748)
2012
19
Different effects of farrerol on an OVA-induced allergic asthma and LPS-induced acute lung injury. (22563373)
2012
20
Pooled genome-wide analysis to identify novel risk loci for pediatric allergic asthma. (21359210)
2011
21
Cigarette smoke exacerbates mouse allergic asthma through Smad proteins expressed in mast cells. (21496353)
2011
22
Naringenin chalcone suppresses allergic asthma by inhibiting the type-2 function of CD4 T cells. (20035147)
2010
23
Pharmacology and immunological actions of a herbal medicine ASHMI on allergic asthma. (19998324)
2010
24
Th2 LCR is essential for regulation of Th2 cytokine genes and for pathogenesis of allergic asthma. (20483988)
2010
25
A complex role for complement in allergic asthma. (20402389)
2010
26
Obesity enhances eosinophilic inflammation in a murine model of allergic asthma. (20100278)
2010
27
In vivo disruption of TGF-beta signaling by Smad7 in airway epithelium alleviates allergic asthma but aggravates lung carcinogenesis in mouse. (20405019)
2010
28
Anti-IgE therapy with omalizumab decreases endothelin-1 in exhaled breath condensate of patients with severe persistent allergic asthma. (20588001)
2010
29
Low dose oral administration of cytokines for treatment of allergic asthma. (19464382)
2009
30
Simultaneous occurrence of chronic autoimmune urticaria and non-allergic asthma: a common mechanism? (19585861)
2009
31
Early activation of coagulation after allergen challenge in patients with allergic asthma. (19552679)
2009
32
Expression of survivin in lung eosinophils is associated with pathology in a mouse model of allergic asthma. (19395375)
2009
33
The relationship between the haplotype of T cells immunoglobulin mucin-3 gene and allergic asthma in the Han population from Hubei province of China]. (18785518)
2008
34
Analysis of -675 4 g/5 G SERPINE1 and C-159T CD14 polymorphisms in house dust mite-allergic asthma patients. (18714537)
2008
35
Sex-related splenocyte function in a murine model of allergic asthma. (18498415)
2008
36
Maternal tolerance achieved during pregnancy is transferred to the offspring via breast milk and persistently protects the offspring from allergic asthma. (18778271)
2008
37
Macrophage migration inhibitory factor is essential for allergic asthma but not for Th2 differentiation. (17373669)
2007
38
Study on relationship between polymorphism sites of TIM4 and allergic asthma in the population of Han nationality from Hubei province of China]. (17407086)
2007
39
Study on the association of single nucleotide polymorphisms and haplotypes of GPR154 gene with allergic asthma in Han nationality in Hubei Chinese population]. (17285544)
2007
40
Blocking IL-25 prevents airway hyperresponsiveness in allergic asthma. (17889290)
2007
41
Histamine 4 receptor activation induces recruitment of FoxP3+ T cells and inhibits allergic asthma in a murine model. (17548646)
2007
42
Modeling the airway epithelium in allergic asthma: interleukin-13- induced effects in differentiated murine tracheal epithelial cells. (16223336)
2005
43
Altered intracellular expression of the chemokines MIP-1alpha, MIP-1beta and IL-8 by peripheral blood CD4+ and CD8+ T cells in mild allergic asthma. (12653799)
2003
44
Anti-immunoglobulin E (omalizumab) therapy in allergic asthma. (11704612)
2001
45
Effect of interleukin-16-blocking peptide on parameters of allergic asthma in a murine model. (10585533)
1999
46
Differential effects of endogenous and exogenous interferon-gamma on immunoglobulin E, cellular infiltration, and airway responsiveness in a murine model of allergic asthma. (9806748)
1998
47
Immunohistochemical characterization of the cellular infiltrate in airway mucosa of toluene diisocyanate (TDI)-induced asthma: comparison with allergic asthma. (9539314)
1998
48
Allergen-induced CD23 on CD4+ T lymphocytes and CD21 on B lymphocytes in patients with allergic asthma: evidence and regulation. (7910139)
1994
49
Anti-IgE autoantibodies in asthma: a diagnostic artefact or an explanation for non-allergic asthma? (8171227)
1994
50
Influence of allergen avoidance at high altitude on serum markers of eosinophil activation in children with allergic asthma. (10779296)
1993

Variations for Allergic Asthma

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Expression for genes affiliated with Allergic Asthma

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Search GEO for disease gene expression data for Allergic Asthma.

Pathways for genes affiliated with Allergic Asthma

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Pathways related to Allergic Asthma according to GeneCards Suite gene sharing:

(show all 13)
idSuper pathways (with members indented)ScoreTop Affiliating Genes
19.9TBX21, IL13
2
Show member pathways
9.5MS4A2, FCER1A, IGHE
3
Show member pathways
Immune response T cell receptor signaling pathway58
Immune response CD28 signaling58
Immune response ICOS pathway in T helper cell58
9.5MS4A2, FCER1A, IGHE
4
Show member pathways
Immune response BCR pathway58
Fc-epsilon receptor I signaling in mast cells36
9.3IGHE, FCER1A, MS4A2, IL13
5
Show member pathways
9.0IL13, CCL25, MS4A2, FCER1A
6
Show member pathways
8.0CCL27, CCL25, CCL18, CCL24
7
Show member pathways
8.0CCL24, CCL18, CCL25, CCL27
8
Show member pathways
8.0CCL24, CCL18, CCL25, CCL27
9
Show member pathways
7.7CCL24, CCL18, CCL25, CCL27, IL13
10
Show member pathways
7.7CCL24, CCL18, CCL25, CCL27, IL13
11
Show member pathways
7.7CCL24, CCL18, CCL25, CCL27, IL13
12
Show member pathways
7.4FCER1A, CCL24, CCL18, CCL25, CCL27, IL13
13
Show member pathways
7.1IL13, IL25, CCL27, CCL25, CCL18, CCL24

Compounds for genes affiliated with Allergic Asthma

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Compounds related to Allergic Asthma according to GeneCards Suite gene sharing:

(show all 27)
idCompoundScoreTop Affiliating Genes
1scca14310.2SERPINB4, IL13
2trimellitic anhydride4310.2IL13, IGHE
3methyltetrahydrophthalic anhydride4310.2IGHE, IL13
4ovomucoid4310.2IL13, IGHE
5desloratadine43 1211.2IGHE, IL13
6praziquantel43 1211.1IL13, IGHE
7penicillin4310.1IL13, IGHE
8montelukast43 49 28 1213.1IL13, IGHE
9mycophenolic acid43 49 1212.1IGHE, IL13
10budesonide43 49 1212.1IL13, IGHE
11salbutamol43 49 28 24 1214.1IGHE, IL13
12fluticasone propionate43 49 59 1213.0IGHE, IL13
13pgd24310.0IL13, IGHE
14methacholine43 49 1211.9IL13, IGHE
15omalizumab43 1210.7IL13, MS4A2, FCER1A, IGHE
16acetylcholine43 49 28 24 1213.5IGHE, IL13, CD160
17cyclosporin a43 28 5911.4CD160, IL13, IGHE
18capsaicin43 2810.4CD160, IGHE
19actinomycin d439.2IGHE, CCL24, IL13
20ccl443 2810.2IL13, CCL27, CCL18
21allergens439.1IGHE, MS4A2, CCL27, IL13
22histamine43 28 2411.0IGHE, FCER1A, CCL24, IL13, CD160
23dexamethasone43 49 28 1211.7IL13, CCL27, CCL18, IGHE
24ccl343 289.7CCL24, CCL18, CCL27, IL13
25alanine438.7IL13, CCL27, CCL18, IGHE
26tarc438.4IGHE, CCL24, CCL18, CCL27, IL13
27rantes438.1IL13, CCL27, CCL25, CCL18, CCL24

GO Terms for genes affiliated with Allergic Asthma

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Cellular components related to Allergic Asthma according to GeneCards Suite gene sharing:

idNameGO IDScoreTop Affiliating Genes
1external side of plasma membraneGO:00098979.7IL13, MS4A2, FCER1A
2extracellular regionGO:00055767.3GZMK, IGHE, SERPINB4, CCL25, CCL27, IL13
3extracellular spaceGO:00056157.0CCL27, SERPINB4, CCL24, CCL18, CCL25, IL13

Biological processes related to Allergic Asthma according to GeneCards Suite gene sharing:

(show all 7)
idNameGO IDScoreTop Affiliating Genes
1positive regulation of mast cell degranulationGO:00433069.6MS4A2, FCER1A
2Fc-epsilon receptor signaling pathwayGO:00380959.5MS4A2, FCER1A, IGHE
3cell chemotaxisGO:00603268.5CCL27, CCL25, CCL18
4inflammatory responseGO:00069548.4MS4A2, CCL24, CCL18, CCL25, IL13
5cell-cell signalingGO:00072678.3CCL24, CCL18, CCL27, IL13
6chemotaxisGO:00069358.1CCL24, CCL18, CCL25, CCL27
7immune responseGO:00069557.2IL13, CCL27, CCL25, CCL18, CCL24, MS4A2

Molecular functions related to Allergic Asthma according to GeneCards Suite gene sharing:

idNameGO IDScoreTop Affiliating Genes
1IgE bindingGO:00198639.9MS4A2, FCER1A
2chemokine activityGO:00080097.7CCL27, CCL25, CCL18, CCL24

Products for genes affiliated with Allergic Asthma

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Sources for Allergic Asthma

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3CDC
13ExPASy
14FMA
22GTR
23HGMD
24HMDB
25ICD10
26ICD10 via Orphanet
27ICD9CM
28IUPHAR
29KEGG
33MeSH
34MESH via Orphanet
35MGI
38NCIt
39NDF-RT
42NINDS
43Novoseek
45OMIM
46OMIM via Orphanet
50PubMed
51QIAGEN
56SNOMED-CT via Orphanet
60UMLS
61UMLS via Orphanet