MCID: ALL006
MIFTS: 60

Allergic Asthma malady

Immune diseases category

Summaries for Allergic Asthma

About this section
Sources:
8Disease Ontology, 32MalaCards
See all sources

Fully expand this MalaCard

Export this MalaCard
Disease Ontology:8 An asthma that is characterized by symptoms that are triggered by an allergic reaction caused by inhaled allergens such as dust mite allergen, pet dander, pollen and mold. allergic asthma is airway obstruction and inflammation that is partially reversible with medication. the disease has symptom coughing, has symptom wheezing, has symptom shortness of breath or has symptom rapid breathing, and has symptom chest tightness.

MalaCards: Allergic Asthma, also known as extrinsic asthma with status asthmaticus, is related to asthma and rhinitis, and has symptoms including chest tightness, shortness of breath or has_symptom rapid breathing and coughing. An important gene associated with Allergic Asthma is IL13 (interleukin 13), and among its related pathways are Akt Signaling and TGF-Beta Pathway. The compounds omalizumab and dexamethasone have been mentioned in the context of this disorder. Affiliated tissues include t cells, lung and testes, and related mouse phenotypes are immune system and respiratory system.

Aliases & Classifications for Allergic Asthma

About this section
Sources:
8Disease Ontology, 60UMLS, 44Novoseek, 56SNOMED-CT, 27ICD9CM
See all sources

Classifications:

Malacards categories (disease lists): (See all malacards categories)
Anatomical: Immune diseases


Aliases & Descriptions:

allergic asthma 8 60
extrinsic asthma with status asthmaticus 8
extrinsic asthma with acute exacerbation 8
asthma allergic 44


Related Diseases for Allergic Asthma

About this section
Sources:
17GeneCards, 18GeneDecks
See all sources

Diseases related to Allergic Asthma via text searches within MalaCards or GeneCards/GeneDecks gene sharing:

(show top 50)    (show all 96)
idRelated DiseaseScoreTop Affiliating Genes
1asthma32.1IL4, IGHE, RNASE3, IL13, IL5
2rhinitis31.1IGHE, RNASE3, IL13, IL5, IL4, MS4A2
3allergic rhinitis31.1IL4, IL5, IL13, RNASE3, IGHE
4eosinophilia30.8IGHE, RNASE2, IL13, RNASE3, IL4, CCL26
5dermatitis30.6IL4, MS4A2, IL5, CCL18, IGHE, IL13
6atopic dermatitis30.5IL5, IL13, RNASE3, IL17D, MS4A2, IL4
7urticaria30.5IGHE, RNASE3, FCER1A
8allergic bronchopulmonary aspergillosis30.5IL5, IL4, IGHE
9pulmonary eosinophilia30.4IL4, IGHE, IL5, IL13, RNASE3
10rheumatoid arthritis30.3RNASE3, HAVCR1, PPBP, IL13, IL4, CCL18
11intrinsic asthma30.3IL4, IL5, RNASE3, IGHE
12arthritis30.3IL13, CISH, IL4
13hepatitis30.3HAVCR1
14skin disease30.0IL4, IL5, IL13, RNASE3, IGHE, CCL18
15food allergy30.0IL4, RNASE3, IL13, IGHE, IL5
16keratoconjunctivitis30.0IL5, RNASE3, IL13
17eosinophilic gastroenteritis30.0IGHE, IL5
18pulmonary fibrosis30.0CCL18, IL13
19pneumonia30.0IL13, CCL18, IL5
20toxocariasis30.0IGHE, RNASE3
21contact dermatitis30.0IL5, IGHE
22allergic urticaria10.3
23obesity10.3
24hepatitis a10.2
25hepatitis c10.0
26interstitial emphysema10.0
27common variable immunodeficiency10.0
28chronic rhinitis10.0
29lichen planus10.0
30cough variant asthma10.0
31allergic contact dermatitis10.0
32aspergillosis10.0
33congestive heart failure10.0
34gastroenteritis10.0
35hypertension10.0
36influenza10.0
37ischemia10.0
38periodontitis10.0
39pulmonary emphysema10.0
40atopy10.0HAVCR1, IGHE, RNASE3, IL13, IL5, IL4
41allergic conjunctivitis10.0IGHE, RNASE3, IL13, IL4, IL5
42bronchiolitis10.0RNASE3, IL13, IL5, IGHE
43schistosomiasis10.0IL4, IGHE, IL5, IL13, PPBP, RNASE3
44psoriasis10.0IL17D, IL5, IL13, RNASE3, CCL18, IL4
45vernal keratoconjunctivitis10.0IL4, IL5, IL13, RNASE3, IGHE
46helminthiasis10.0IGHE, RNASE3, IL13, IL5
47eosinophilic pneumonia10.0IL5, RNASE3, IGHE, IL13
48kimura disease10.0IL5, RNASE3, IGHE
49eosinophilic esophagitis10.0CCL26, IL5, RNASE2
50leukemia10.0CISH, PPBP, RNASE3, IL4

Graphical network of the top 20 diseases related to Allergic Asthma:



Diseases related to allergic asthma

Clinical Features for Allergic Asthma

About this section
Sources:
8Disease Ontology
See all sources


Symptoms:

8
  • chest tightness
  • shortness of breath or has_symptom rapid breathing
  • coughing
  • wheezing

Drugs & Therapeutics for Allergic Asthma

About this section
Sources:
5CenterWatch, 41NIH Clinical Center, 6ClinicalTrials, 60UMLS, 40NDF-RT
See all sources

Approved drugs:

Search CenterWatch for Allergic Asthma

Drug clinical trials:

Search ClinicalTrials for Allergic Asthma

Search NIH Clinical Center for Allergic Asthma

Highlights from CenterWatch's Drugs in Clinical Trials Database for Allergic Asthma:

idCompanyCompoundMechanismPhase
1Rigel PharmaceuticalsR343An inhalation formulation of a small-molecule syk kinase inhibitorII

Genetic Tests for Allergic Asthma

About this section

Anatomical Context for Allergic Asthma

About this section
Sources:
32MalaCards
See all sources

MalaCards organs/tissues related to Allergic Asthma:

32
T cells, Lung, Testes, Skin, Smooth muscle, Monocytes, Bone, Breast, Myeloid, Heart, B cells, Bone marrow, Endothelial, Colon, Liver, Spleen, Nk cells

Animal Models for Allergic Asthma or affiliated genes

About this section
Sources:
36MGI
See all sources

MGI Mouse Phenotypes related to Allergic Asthma:

36
idDescriptionMGI Source AccessionScoreTop Affiliating Genes
1MP:000538710.8MS4A2, CCL25, HAVCR1, TFF2, TBX21, IGHE
2MP:000538810.7IL4, IL5, IL25, IL13, TBX21, HAVCR1
3MP:000539710.6CCL25, HAVCR1, TBX21, IGHE, IL13, IL25
4MP:000538110.4CCL25, TFF2, TBX21, IL13, IL25, IL5

Publications for Allergic Asthma

About this section
Sources:
50PubMed
See all sources

Articles related to Allergic Asthma:

(show top 50)    (show all 931)
idTitleAuthorsYear
1
A novel synthetic mycolic Acid inhibits bronchial hyperresponsiveness and allergic inflammation in a mouse model of asthma. (24404398)
2014
2
Oleanolic acid suppresses ovalbumin-induced airway inflammation and Th2-mediated allergic asthma by modulating the transcription factors T-bet, GATA-3, RORI^t and Foxp3 in asthmatic mice. (24374304)
2014
3
Does allergic rhinitis make a difference to the respiratory resistance and reactance of asthma? (23796144)
2013
4
Matrix metalloproteinase-9 increases in the sputum from allergic occupational asthma patients after specific inhalation challenge. (23018543)
2013
5
Role of plasmacytoid dendritic cell subsets in allergic asthma. (23662841)
2013
6
Population-based efficacy modeling of omalizumab in patients with severe allergic asthma inadequately controlled with standard therapy. (23413101)
2013
7
A hospital-based survey on the prevalence of bronchial asthma in patients with allergic rhinitis in southern China. (24274226)
2013
8
CD24(hi) CD27(+) B cells from allergic asthma patients have impaired regulatory activity in response to LPS. (24261983)
2013
9
Acupuncture in Patients Suffering from Allergic Asthma: Is It Worth Additional Costs? (24256028)
2013
10
Fish intake during pregnancy and the risk of child asthma and allergic rhinitis - longitudinal evidence from the Danish National Birth Cohort. (23473120)
2013
11
Occupational immediate-type allergic asthma due to potassium tetrachloroplatinate in production of cytotoxic drugs. (22826048)
2013
12
Low frequency of CD8+CD25+FOXP3(BRIGHT) T cells and FOXP3 mRNA expression in the peripheral blood of allergic asthma patients. (22824748)
2012
13
Association of Hepatitis A exposure and TIM-1 with childhood allergic asthma. (22857392)
2012
14
Lactobacillus gasseri suppresses Th17 pro-inflammatory response and attenuates allergen-induced airway inflammation in a mouse model of allergic asthma. (21996276)
2012
15
Tako-tsubo cardiomyopathy following an allergic asthma attack after cephalosporin administration. (22225762)
2012
16
Electroacupuncture Attenuates Ovalbumin-Induced Allergic Asthma via Modulating CD4(+)CD25(+) Regulatory T Cells. (22649477)
2012
17
Defining the molecular role of gp91phox in the immune manifestation of acute allergic asthma using a preclinical murine model. (22216879)
2012
18
Effects of ionized waterfall aerosol on pediatric allergic asthma. (22861198)
2012
19
Clinical features cannot distinguish allergic from non-allergic asthma in children. (22136286)
2012
20
Pooled genome-wide analysis to identify novel risk loci for pediatric allergic asthma. (21359210)
2011
21
Neutrophil defensins: their possible role in allergic asthma. (21370722)
2011
22
Profiling allergic asthma volatile metabolic patterns using a headspace-solid phase microextraction/gas chromatography based methodology. (21546028)
2011
23
Induction of tolerogenic lung CD4+ T cells by local treatment with a pSTAT-3 and pSTAT-5 inhibitor ameliorated experimental allergic asthma. (21135031)
2011
24
Evaluation of bronchial hyperreactivity with mannitol dry powder challenge test in a paediatric population with intermittent allergic asthma or allergic rhinitis. (22230412)
2011
25
Acinetobacter baumannii infection inhibits airway eosinophilia and lung pathology in a mouse model of allergic asthma. (21789200)
2011
26
Protective effects of Mentha haplocalyx ethanol extract (MH) in a mouse model of allergic asthma. (21108485)
2011
27
Pharmacology and immunological actions of a herbal medicine ASHMI on allergic asthma. (19998324)
2010
28
Anti-IgE therapy with omalizumab decreases endothelin-1 in exhaled breath condensate of patients with severe persistent allergic asthma. (20588001)
2010
29
Incrimination of Blomia tropicalis as a Potent Allergen in House Dust and Its Role in Allergic Asthma in Kolkata Metropolis, India. (23268430)
2010
30
CysLT1-R expression following allergen provocation in asthma and allergic rhinitis. (20462748)
2010
31
Aspergillus hypersensitivity and allergic bronchopulmonary aspergillosis in patients with bronchial asthma: systematic review and meta-analysis. (19723372)
2009
32
A comparison of two sets of microarray experiments to define allergic asthma expression pattern. (19842841)
2009
33
Herpes simplex type I infection and atopy association in Turkish children with asthma and allergic rhinitis. (20124606)
2009
34
Clinical studies of the DP1 antagonist laropiprant in asthma and allergic rhinitis. (19748656)
2009
35
Activation of c-Kit in dendritic cells regulates T helper cell differentiation and allergic asthma. (18454155)
2008
36
T cell-specific T-box transcription factor haplotype is associated with allergic asthma in children. (17949803)
2008
37
Allergic rhinitis and asthma connection: treatment implications. (19173782)
2008
38
The role of histone deacetylases in asthma and allergic diseases. (18234319)
2008
39
Plasminogen activator inhibitor-1 (PAI-1) and urokinase plasminogen activator (uPA) in sputum of allergic asthma patients. (18519237)
2008
40
Chemokine receptor expression on allergen-specific T cells in asthma and allergic bronchopulmonary aspergillosis. (17298426)
2007
41
Allergic conjunctivitis in children with asthma, rhinitis and eczema in a secondary outpatient clinic. (17014628)
2006
42
The research on the correlation between eotaxin-3 gene polymorphisms and allergic asthma]. (16604488)
2006
43
Azoles for allergic bronchopulmonary aspergillosis associated with asthma. (15266440)
2004
44
Omalizumab: a review of its use in the management of allergic asthma. (15219177)
2004
45
The relationship among markers of allergy, asthma, allergic rhinitis, and eczema in Costa Rica. (12000480)
2002
46
Azoles for allergic bronchopulmonary aspergillosis associated with asthma. (11687098)
2001
47
Interleukin-18 and allergic asthma. (11344858)
2000
48
Phenotypic analysis of alveolar macrophages and monocytes in allergic airway inflammation. I. Evidence for activation of alveolar macrophages, but not peripheral blood monocytes, in subjects with allergic rhinitis and asthma. (9117017)
1997
49
Allergic bronchopulmonary aspergillosis: an unusual complication of bronchial asthma. (8920604)
1995
50
Pharmacological characterization of SB 202235, a potent and selective 5-lipoxygenase inhibitor: effects in models of allergic asthma. (7791085)
1995

Genetic Variations for Allergic Asthma

About this section

Expression for genes affiliated with Allergic Asthma

About this section
Sources:
1BioGPS, 15Gene Expression Omnibus DataSets
See all sources
Expression patterns in normal tissues for genes affiliated with Allergic Asthma

Search GEO for disease gene expression data for Allergic Asthma.

Pathways for genes affiliated with Allergic Asthma

About this section
Sources:
51QIAGEN, 29KEGG, 12EMD Millipore, 37NCBI BioSystems Database, 52R&D Systems, 53Reactome
See all sources

Pathways related to Allergic Asthma according to GeneCards/GeneDecks:

(show all 19)
idSuper pathways (with members indented)ScoreTop Affiliating Genes
1
Hide members
10.7CCL26, CCL25, CCL18, PPBP, IL13, IL5
2
Hide members
10.7CCL26, CCL25, CCL18, PPBP, CISH, IL13
3
Hide members
10.7FCER1A, CCL26, CCL25, CCL18, PPBP, IL13
4
Hide members
10.7CCL26, CCL25, CCL18, PPBP, IL13, IL5
5
Hide members
10.7CCL26, CCL25, CCL18, PPBP, IL13, IL5
6
Hide members
10.7IGHE, IL13, IL5, IL4, FCER1A, MS4A2
7
Hide members
10.6CCL25, RNASE3, IL13, IL5, IL4
810.6TBX21, IL13, IL5, IL4
9
Hide members
10.6TBX21, IL13, IL5, IL4
1010.6IL4, IL5, IL13, CISH
1110.6CCL26, IGHE, IL5, IL4
1210.6IL13, IL5, IL4
1310.6IL4, IL5, IL13
1410.6IL4, IL5, IL13
15
Hide members
10.6CCL26, CCL25, CCL18, PPBP
16
Hide members
10.6IL4, IL5, TBX21
17
Hide members
10.6MS4A2, FCER1A, IGHE
18
Immune response NFAT in immune response
Hide members
10.6IGHE, FCER1A, MS4A2
1910.5FCER1A, IL4

Compounds for genes affiliated with Allergic Asthma

About this section
Sources:
44Novoseek, 11DrugBank, 49PharmGKB, 28IUPHAR, 24HMDB, 59Tocris Bioscience, 2BitterDB
See all sources

Compounds related to Allergic Asthma according to GeneCards/GeneDecks:

(show top 50)    (show all 80)
idCompoundScoreTop Affiliating Genes
1omalizumab44 1112.1IGHE, MS4A2, IL4, FCER1A, IL5, IL13
2dexamethasone44 49 28 1114.1CISH, PPBP, CCL18, IGHE, IL13, IL5
3allergens4411.1IGHE, RNASE3, IL13, IL5, IL4, MS4A2
4histamine44 28 2413.1IL4, IGHE, RNASE3, IL5, FCER1A, PPBP
5tarc4411.1CCL26, IL4, IL5, IL13, IGHE, CCL18
6praziquantel44 1112.1IL5, IL13, RNASE3, IGHE, IL4
7montelukast44 49 28 1114.1RNASE3, IL4, IL5, IL13, IGHE
8budesonide44 49 1113.1RNASE3, IGHE, IL13, IL5, IL4
9fluticasone propionate44 49 59 1114.1IL4, IL5, IL13, RNASE3, IGHE
10methacholine44 1112.1IGHE, IL13, IL5, IL4, RNASE3
11salmeterol44 49 28 1114.0IL5, IL13, RNASE3, IL4
12nedocromil sodium4411.0IL5, RNASE3, IGHE, IL4
13azelastine44 1112.0IL4, IL5, RNASE3, IGHE
14penicillin4411.0PPBP, IGHE, IL5, IL13
15vegf4411.0IL4, IL5, IL13, CCL18, RNASE3, IGHE
16rantes4411.0PPBP, RNASE3, IL4
17salbutamol44 49 28 11 2415.0IGHE, RNASE3, IL5, IL13
18pgd24411.0IGHE, IL5, RNASE3, IL13
19unicap4411.0IGHE, IL5, RNASE3
20aspirin44 49 28 2414.0IL4, IL13, RNASE3, TFF2, PPBP
21beclomethasone dipropionate4411.0RNASE3, IGHE, IL5
22capsaicin44 2812.0RNASE3, IL5, TFF2, IGHE
23toluene diisocyanate4411.0IL5, IGHE, RNASE3
24sodium cromoglycate4411.0IL5, RNASE3, IGHE
25desloratadine44 1111.9IGHE, IL13, IL4
26formoterol44 28 1112.9IL4, RNASE3, IL13
27ovomucoid4410.9IGHE
28cetirizine44 28 11 2413.9RNASE3, IL5, IGHE
29pranlukast44 28 1112.9RNASE3, IL5, IL4
30glatiramer acetate44 1111.9IL4, IL5, IL13
31ketotifen44 1111.9IL5, RNASE3, IGHE
32indomethacin44 59 28 1113.9TFF2, IGHE, IL13, IL5, IL4
33itraconazole44 1111.9IGHE, IL5, IL4
34amphotericin b4410.9IL13, IL4, IL5
35leukotriene b444 59 2412.9IL13, IL5, PPBP, RNASE3
36ltd44410.9IL13, RNASE3, IL5
37il-124410.9IL4, IL5, IL13
38prednisolone44 28 1112.9IGHE, RNASE3, IL5, IL13
39trimellitic anhydride4410.8IGHE, IL13
40ltc44410.8RNASE3, IL13, IL5
41hydrocortisone44 2 59 1113.7IGHE
42loteprednol44 1111.7IL4, IL5
43oxazolone4410.7IL13, IL4
44Adenosine-2'-5'-Diphosphate1110.7RNASE3, RNASE2
45tolnaftate4410.7IL4, IL5
46methyltetrahydrophthalic anhydride4410.6IL13, IGHE
47thyroxine44 2411.6IL13, IL4, IL5, IGHE
48fmlp4410.6IL13, IL5, PPBP, RNASE3
49mometasone44 1111.4IL4, IL5
50isoproterenol44 1111.2IL5

GO Terms for genes affiliated with Allergic Asthma

About this section
Sources:
16Gene Ontology
See all sources

Cellular components related to Allergic Asthma according to GeneCards/GeneDecks:

idNameGO IDScoreTop Affiliating Genes
1extracellular spaceGO:00561510.7SERPINB4, CCL26, CCL25, CCL18, PPBP, TFF2
2external side of plasma membraneGO:00989710.6MS4A2, FCER1A, IL4, IL13
3extracellular regionGO:00557610.4CCL25, GZMK, PPBP, IGHE, RNASE3, RNASE2

Biological processes related to Allergic Asthma according to GeneCards/GeneDecks:

(show all 9)
idNameGO IDScoreTop Affiliating Genes
1immune responseGO:00695510.9SERPINB4, CCL26, CCL25, CCL18, IGHE, IL13
2inflammatory responseGO:00695410.8CCL26, CCL25, CCL18, IL13, IL5, IL17D
3chemotaxisGO:00693510.8CCL26, CCL25, CCL18, RNASE2, IL4
4positive regulation of B cell proliferationGO:03089010.7IL4, IL5, IL13
5regulation of proton transportGO:01015510.6IL4, IL13
6positive regulation of isotype switching to IgG isotypesGO:04830410.5TBX21, IL4
7RNA catabolic processGO:00640110.5RNASE2, RNASE3
8negative regulation of macrophage activationGO:04303110.4TFF2, IL4
9positive regulation of mast cell degranulationGO:04330610.2MS4A2, FCER1A

Molecular functions related to Allergic Asthma according to GeneCards/GeneDecks:

idNameGO IDScoreTop Affiliating Genes
1chemokine activityGO:00800910.6PPBP, CCL18, CCL25, CCL26
2cytokine activityGO:00512510.6IL13, IL25, IL5, IL17D, IL4
3pancreatic ribonuclease activityGO:00452210.5RNASE2, RNASE3
4IgE bindingGO:01986310.4MS4A2, FCER1A
5ribonuclease activityGO:00454010.2RNASE2, RNASE3

Products for genes affiliated with Allergic Asthma

About this section
  • Antibodies
  • Proteins
  • Lysates
  • Antibodies

Sources for Allergic Asthma

About this section
3CDC
13ExPASy
14FMA
22GTR
23HGMD
24HMDB
25ICD10
26ICD10 via Orphanet
27ICD9CM
28IUPHAR
29KEGG
34MeSH
35MESH via Orphanet
36MGI
39NCIt
40NDF-RT
43NINDS
44Novoseek
46OMIM
47OMIM via Orphanet
50PubMed
51QIAGEN
57SNOMED-CT via Orphanet
60UMLS
61UMLS via Orphanet