MCID: ALL006
MIFTS: 55

Allergic Asthma malady

Respiratory diseases, Immune diseases categories
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Summaries for Allergic Asthma

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Disease Ontology:8 An asthma that is characterized by symptoms that are triggered by an allergic reaction caused by inhaled allergens such as dust mite allergen, pet dander, pollen and mold. allergic asthma is airway obstruction and inflammation that is partially reversible with medication. the disease has symptom coughing, has symptom wheezing, has symptom shortness of breath or has symptom rapid breathing, and has symptom chest tightness.

MalaCards based summary: Allergic Asthma, also known as extrinsic asthma with status asthmaticus, is related to asthma and rhinitis, and has symptoms including An important gene associated with Allergic Asthma is IL13 (interleukin 13), and among its related pathways are IL12 signaling mediated by STAT4 and PI-3K cascade. The compounds scca1 and trimellitic anhydride have been mentioned in the context of this disorder. Affiliated tissues include t cells, lung and neutrophil, and related mouse phenotypes are immune system and hematopoietic system.

Aliases & Classifications for Allergic Asthma

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Allergic Asthma, Aliases & Descriptions:

Name: Allergic Asthma 8 62
Extrinsic Asthma with Status Asthmaticus 8 62
 
Extrinsic Asthma with Acute Exacerbation 8
Asthma Allergic 44


Classifications:

Malacards categories (disease lists): (See all malacards categories)
Anatomical: Respiratory diseases, Immune diseases


Related Diseases for Allergic Asthma

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Diseases related to Allergic Asthma via text searches within MalaCards or GeneCards/GeneDecks gene sharing:

(show top 50)    (show all 57)
idRelated DiseaseScoreTop Affiliating Genes
1asthma32.7IGHE, IL13
2rhinitis31.5IGHE, MS4A2, IL13
3allergic rhinitis31.4IL13, IGHE
4pulmonary eosinophilia31.0IL13, IGHE
5urticaria30.8FCER1A, IGHE
6food allergy30.6IGHE, IL13
7eosinophilia30.6IGHE, CCL24, CCL27, IL13
8atopy30.4IL13, MS4A2, IGHE
9vernal keratoconjunctivitis30.3IL13, CCL24, IGHE
10dermatitis30.1IGHE, MS4A2, CCL18, CCL27, IL13
11atopic dermatitis30.1IL13, CCL27, CCL18, MS4A2, IGHE
12allergic bronchopulmonary aspergillosis10.4
13blindness10.4
14helminthiasis10.4IGHE, IL13
15allergic conjunctivitis10.4IL13, IGHE
16conjunctivitis10.4MS4A2, IGHE
17eosinophilic pneumonia10.3IL13, IGHE
18filariasis10.3IGHE, IL13
19obesity10.3
20mastocytosis10.3IGHE, IL13
21bronchiolitis10.3IL13, IGHE
22respiratory failure10.3IL13, IGHE
23schistosomiasis10.3IL13, IGHE
24arthritis10.2
25hepatitis10.2
26rheumatoid arthritis10.2
27bullous pemphigoid10.2IGHE, IL13
28chronic obstructive pulmonary disease10.1
29common variable immunodeficiency10.1
30congestive heart failure10.1
31hypertension10.1
32pulmonary fibrosis10.1
33sinusitis10.1
34lichen planus10.1
35hepatitis c10.1
36intrinsic asthma10.1
37toxocariasis10.1
38hepatitis a10.1
39cough variant asthma10.1
40eosinophilic gastroenteritis10.1
41aspergillosis10.1
42congenital heart disease10.1
43contact dermatitis10.1
44gastroenteritis10.1
45influenza10.1
46ischemia10.1
47keratoconjunctivitis10.1
48periodontitis10.1
49pneumonia10.1
50stachybotrys chartarum10.1

Graphical network of the top 20 diseases related to Allergic Asthma:



Diseases related to allergic asthma

Symptoms for Allergic Asthma

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Drugs & Therapeutics for Allergic Asthma

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Drug clinical trials:

Search ClinicalTrials for Allergic Asthma

Search NIH Clinical Center for Allergic Asthma

Genetic Tests for Allergic Asthma

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Anatomical Context for Allergic Asthma

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MalaCards organs/tissues related to Allergic Asthma:

32
T cells, Lung, Neutrophil, Smooth muscle, Skin, Testes, Bone, Monocytes, Heart, Breast, Myeloid, B cells, Bone marrow, Spleen, Endothelial

Animal Models for Allergic Asthma or affiliated genes

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MGI Mouse Phenotypes related to Allergic Asthma:

36
idDescriptionMGI Source AccessionScoreTop Affiliating Genes
1MP:00053877.5FCER1A, MS4A2, CCL24, CCL25, IL25, IL13
2MP:00053977.2TBX21, IGHE, FCER1A, MS4A2, CCL24, CCL25

Publications for Allergic Asthma

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Articles related to Allergic Asthma:

(show top 50)    (show all 660)
idTitleAuthorsYear
1
Expression and targeting of lymphocyte function-associated antigen 1 (LFA-1) on white blood cells for treatment of allergic asthma. (25341726)
2014
2
Reprint of: Perinatal and early childhood environmental factors influencing allergic asthma immunopathogenesis. (25308874)
2014
3
Effects of taraxasterol on ovalbumin-induced allergic asthma in mice. (23727181)
2013
4
Roles of histone hypoacetylation in LAT expression on T cells and Th2 polarization in allergic asthma. (23360572)
2013
5
Anaphylatoxins coordinate innate and adaptive immune responses in allergic asthma. (23694705)
2013
6
Bone marrow mononuclear cell therapy in experimental allergic asthma: intratracheal versus intravenous administration. (23164835)
2013
7
Experimental model of allergic asthma. (22836618)
2013
8
The eXpeRience registry: the 'real-world' effectiveness of omalizumab in allergic asthma. (23721684)
2013
9
Concomitant asthma medications in moderate-to-severe allergic asthma treated with omalizumab. (23083840)
2013
10
Anti-asthmatic Effects of Baicalin in a Mouse Model of Allergic Asthma. (23580257)
2013
11
Phenotypic characterization of ex vivo CD4+CD25highCD127low immune regulatory T cells in allergic asthma: pathogenesis relevance of their FoxP3, GITR, CTLA-4 and FAS expressions. (23241113)
2012
12
The single nucleotide polymorphism CRTh2 rs533116 is associated with allergic asthma and increased expression of CRTh2. (22947041)
2012
13
The effects of (A+)-Praeruptorin A on airway inflammation, remodeling and transforming growth factor-I^1/Smad signaling pathway in a murine model of allergic asthma. (22974581)
2012
14
Crude extracts of Caenorhabditis elegans suppress airway inflammation in a murine model of allergic asthma. (22558152)
2012
15
A study on indoor environment contaminants related to dust mite in dwellings of allergic asthma patients and of healthy subjects. (22426097)
2012
16
Association of allergic asthma emergency room visits with the main biological and chemical air pollutants. (22750174)
2012
17
Low frequency of CD8+CD25+FOXP3(BRIGHT) T cells and FOXP3 mRNA expression in the peripheral blood of allergic asthma patients. (22824748)
2012
18
Different effects of farrerol on an OVA-induced allergic asthma and LPS-induced acute lung injury. (22563373)
2012
19
Pooled genome-wide analysis to identify novel risk loci for pediatric allergic asthma. (21359210)
2011
20
Cigarette smoke exacerbates mouse allergic asthma through Smad proteins expressed in mast cells. (21496353)
2011
21
Naringenin chalcone suppresses allergic asthma by inhibiting the type-2 function of CD4 T cells. (20035147)
2010
22
Omalizumab reduces oral corticosteroid use in patients with severe allergic asthma: real-life data. (20599369)
2010
23
Pharmacology and immunological actions of a herbal medicine ASHMI on allergic asthma. (19998324)
2010
24
Th2 LCR is essential for regulation of Th2 cytokine genes and for pathogenesis of allergic asthma. (20483988)
2010
25
A complex role for complement in allergic asthma. (20402389)
2010
26
Obesity enhances eosinophilic inflammation in a murine model of allergic asthma. (20100278)
2010
27
In vivo disruption of TGF-beta signaling by Smad7 in airway epithelium alleviates allergic asthma but aggravates lung carcinogenesis in mouse. (20405019)
2010
28
Anti-IgE therapy with omalizumab decreases endothelin-1 in exhaled breath condensate of patients with severe persistent allergic asthma. (20588001)
2010
29
Low dose oral administration of cytokines for treatment of allergic asthma. (19464382)
2009
30
Simultaneous occurrence of chronic autoimmune urticaria and non-allergic asthma: a common mechanism? (19585861)
2009
31
Early activation of coagulation after allergen challenge in patients with allergic asthma. (19552679)
2009
32
Expression of survivin in lung eosinophils is associated with pathology in a mouse model of allergic asthma. (19395375)
2009
33
The relationship between the haplotype of T cells immunoglobulin mucin-3 gene and allergic asthma in the Han population from Hubei province of China]. (18785518)
2008
34
Analysis of -675 4 g/5 G SERPINE1 and C-159T CD14 polymorphisms in house dust mite-allergic asthma patients. (18714537)
2008
35
Sex-related splenocyte function in a murine model of allergic asthma. (18498415)
2008
36
Maternal tolerance achieved during pregnancy is transferred to the offspring via breast milk and persistently protects the offspring from allergic asthma. (18778271)
2008
37
Macrophage migration inhibitory factor is essential for allergic asthma but not for Th2 differentiation. (17373669)
2007
38
Study on relationship between polymorphism sites of TIM4 and allergic asthma in the population of Han nationality from Hubei province of China]. (17407086)
2007
39
Study on the association of single nucleotide polymorphisms and haplotypes of GPR154 gene with allergic asthma in Han nationality in Hubei Chinese population]. (17285544)
2007
40
Blocking IL-25 prevents airway hyperresponsiveness in allergic asthma. (17889290)
2007
41
Histamine 4 receptor activation induces recruitment of FoxP3+ T cells and inhibits allergic asthma in a murine model. (17548646)
2007
42
Modeling the airway epithelium in allergic asthma: interleukin-13- induced effects in differentiated murine tracheal epithelial cells. (16223336)
2005
43
Altered intracellular expression of the chemokines MIP-1alpha, MIP-1beta and IL-8 by peripheral blood CD4+ and CD8+ T cells in mild allergic asthma. (12653799)
2003
44
Anti-immunoglobulin E (omalizumab) therapy in allergic asthma. (11704612)
2001
45
Effect of interleukin-16-blocking peptide on parameters of allergic asthma in a murine model. (10585533)
1999
46
Differential effects of endogenous and exogenous interferon-gamma on immunoglobulin E, cellular infiltration, and airway responsiveness in a murine model of allergic asthma. (9806748)
1998
47
Immunohistochemical characterization of the cellular infiltrate in airway mucosa of toluene diisocyanate (TDI)-induced asthma: comparison with allergic asthma. (9539314)
1998
48
Allergen-induced CD23 on CD4+ T lymphocytes and CD21 on B lymphocytes in patients with allergic asthma: evidence and regulation. (7910139)
1994
49
Anti-IgE autoantibodies in asthma: a diagnostic artefact or an explanation for non-allergic asthma? (8171227)
1994
50
Influence of allergen avoidance at high altitude on serum markers of eosinophil activation in children with allergic asthma. (10779296)
1993

Variations for Allergic Asthma

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Expression for genes affiliated with Allergic Asthma

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Expression patterns in normal tissues for genes affiliated with Allergic Asthma

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Pathways for genes affiliated with Allergic Asthma

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Pathways related to Allergic Asthma according to GeneCards/GeneDecks:

(show all 13)
idSuper pathways (with members indented)ScoreTop Affiliating Genes
19.9TBX21, IL13
2
Show member pathways
9.5MS4A2, FCER1A, IGHE
3
Show member pathways
Immune response T cell receptor signaling pathway60
Immune response CD28 signaling60
Immune response ICOS pathway in T helper cell60
9.5MS4A2, FCER1A, IGHE
4
Show member pathways
Immune response BCR pathway60
Fc-epsilon receptor I signaling in mast cells37
9.3IGHE, FCER1A, MS4A2, IL13
5
Show member pathways
9.0IL13, CCL25, MS4A2, FCER1A
6
Show member pathways
8.0CCL27, CCL25, CCL18, CCL24
7
Show member pathways
8.0CCL24, CCL18, CCL25, CCL27
8
Show member pathways
8.0CCL24, CCL18, CCL25, CCL27
9
Show member pathways
7.7CCL24, CCL18, CCL25, CCL27, IL13
10
Show member pathways
7.7CCL24, CCL18, CCL25, CCL27, IL13
11
Show member pathways
7.7CCL24, CCL18, CCL25, CCL27, IL13
12
Show member pathways
7.4FCER1A, CCL24, CCL18, CCL25, CCL27, IL13
13
Show member pathways
7.1IL13, IL25, CCL27, CCL25, CCL18, CCL24

Compounds for genes affiliated with Allergic Asthma

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Compounds related to Allergic Asthma according to GeneCards/GeneDecks:

(show all 27)
idCompoundScoreTop Affiliating Genes
1scca14410.2SERPINB4, IL13
2trimellitic anhydride4410.2IL13, IGHE
3methyltetrahydrophthalic anhydride4410.2IGHE, IL13
4ovomucoid4410.2IL13, IGHE
5desloratadine44 1111.2IGHE, IL13
6praziquantel44 1111.1IL13, IGHE
7penicillin4410.1IL13, IGHE
8montelukast44 50 28 1113.1IL13, IGHE
9mycophenolic acid44 50 1112.1IGHE, IL13
10budesonide44 50 1112.1IL13, IGHE
11salbutamol44 50 28 24 1114.1IGHE, IL13
12fluticasone propionate44 50 61 1113.0IGHE, IL13
13pgd24410.0IL13, IGHE
14methacholine44 50 1111.9IL13, IGHE
15omalizumab44 1110.7IL13, MS4A2, FCER1A, IGHE
16acetylcholine44 50 28 24 1113.5IGHE, IL13, CD160
17cyclosporin a44 28 6111.4CD160, IL13, IGHE
18capsaicin44 2810.4CD160, IGHE
19actinomycin d449.2IGHE, CCL24, IL13
20ccl444 2810.2IL13, CCL27, CCL18
21allergens449.1IGHE, MS4A2, CCL27, IL13
22histamine44 28 2411.0IGHE, FCER1A, CCL24, IL13, CD160
23dexamethasone44 50 28 1111.7IL13, CCL27, CCL18, IGHE
24ccl344 289.7CCL24, CCL18, CCL27, IL13
25alanine448.7IL13, CCL27, CCL18, IGHE
26tarc448.4IGHE, CCL24, CCL18, CCL27, IL13
27rantes448.1IL13, CCL27, CCL25, CCL18, CCL24

GO Terms for genes affiliated with Allergic Asthma

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Cellular components related to Allergic Asthma according to GeneCards/GeneDecks:

idNameGO IDScoreTop Affiliating Genes
1external side of plasma membraneGO:0098979.7IL13, MS4A2, FCER1A
2extracellular regionGO:0055767.3IGHE, SERPINB4, CCL25, CCL27, IL13, GZMK
3extracellular spaceGO:0056157.0IL13, SERPINB4, CCL24, CCL18, CCL25, CCL27

Biological processes related to Allergic Asthma according to GeneCards/GeneDecks:

(show all 7)
idNameGO IDScoreTop Affiliating Genes
1positive regulation of mast cell degranulationGO:0433069.6MS4A2, FCER1A
2Fc-epsilon receptor signaling pathwayGO:0380959.5MS4A2, FCER1A, IGHE
3cell chemotaxisGO:0603268.5CCL27, CCL25, CCL18
4inflammatory responseGO:0069548.4MS4A2, CCL24, CCL18, CCL25, IL13
5cell-cell signalingGO:0072678.3CCL24, CCL18, CCL27, IL13
6chemotaxisGO:0069358.1CCL24, CCL18, CCL25, CCL27
7immune responseGO:0069557.2IL13, CCL27, CCL25, CCL18, CCL24, MS4A2

Molecular functions related to Allergic Asthma according to GeneCards/GeneDecks:

idNameGO IDScoreTop Affiliating Genes
1IgE bindingGO:0198639.9MS4A2, FCER1A
2chemokine activityGO:0080097.7CCL27, CCL25, CCL18, CCL24

Products for genes affiliated with Allergic Asthma

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Sources for Allergic Asthma

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3CDC
13ExPASy
14FMA
22GTR
23HGMD
24HMDB
25ICD10
26ICD10 via Orphanet
27ICD9CM
28IUPHAR
29KEGG
34MeSH
35MESH via Orphanet
36MGI
39NCIt
40NDF-RT
43NINDS
44Novoseek
46OMIM
47OMIM via Orphanet
51PubMed
52QIAGEN
58SNOMED-CT via Orphanet
62UMLS
63UMLS via Orphanet