MCID: ALL006
MIFTS: 54

Allergic Asthma malady

Respiratory diseases, Immune diseases categories

Summaries for Allergic Asthma

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Sources:
9Disease Ontology, 34MalaCards
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Disease Ontology:9 An asthma that is characterized by symptoms that are triggered by an allergic reaction caused by inhaled allergens such as dust mite allergen, pet dander, pollen and mold. allergic asthma is airway obstruction and inflammation that is partially reversible with medication. the disease has symptom coughing, has symptom wheezing, has symptom shortness of breath or has symptom rapid breathing, and has symptom chest tightness.

MalaCards: Allergic Asthma, also known as extrinsic asthma with status asthmaticus, is related to asthma and rhinitis, and has symptoms including chest tightness, shortness of breath or has_symptom rapid breathing and coughing. An important gene associated with Allergic Asthma is IL13 (interleukin 13), and among its related pathways are IL12 signaling mediated by STAT4 and PI-3K cascade. The compounds scca1 and trimellitic anhydride have been mentioned in the context of this disorder. Affiliated tissues include t cells, lung and smooth muscle, and related mouse phenotypes are immune system and hematopoietic system.

Aliases & Classifications for Allergic Asthma

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Sources:
9Disease Ontology, 63UMLS, 46Novoseek, 59SNOMED-CT, 28ICD9CM
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Classifications:

Malacards categories (disease lists): (See all malacards categories)
Anatomical: Respiratory diseases, Immune diseases


Aliases & Descriptions:

allergic asthma 9 63
extrinsic asthma with status asthmaticus 9
extrinsic asthma with acute exacerbation 9
asthma allergic 46


Related Diseases for Allergic Asthma

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Sources:
18GeneCards, 19GeneDecks
See all sources

Diseases related to Allergic Asthma via text searches within MalaCards or GeneCards/GeneDecks gene sharing:

(show top 50)    (show all 55)
idRelated DiseaseScoreTop Affiliating Genes
1asthma32.3IGHE, IL13
2rhinitis31.2IGHE, MS4A2, IL13
3allergic rhinitis31.0IL13, IGHE
4eosinophilia30.8IGHE, CCL24, CCL27, IL13
5urticaria30.6FCER1A, IGHE
6pulmonary eosinophilia30.6IL13, IGHE
7dermatitis30.5IGHE, MS4A2, CCL18, CCL27, IL13
8atopic dermatitis30.4IL13, CCL27, CCL18, MS4A2, IGHE
9food allergy30.2IGHE, IL13
10atopy30.2IL13, MS4A2, IGHE
11vernal keratoconjunctivitis30.2IL13, CCL24, IGHE
12allergic bronchopulmonary aspergillosis10.4
13blindness10.4
14obesity10.3
15hepatitis10.2
16helminthiasis10.1IGHE, IL13
17allergic conjunctivitis10.1IL13, IGHE
18conjunctivitis10.1MS4A2, IGHE
19eosinophilic pneumonia10.1IL13, IGHE
20filariasis10.1IGHE, IL13
21hepatitis c10.1
22lichen planus10.1
23intrinsic asthma10.1
24eosinophilic gastroenteritis10.1
25toxocariasis10.1
26hepatitis a10.1
27common variable immunodeficiency10.1
28cough variant asthma10.1
29arthritis10.1
30aspergillosis10.1
31congenital heart disease10.1
32congestive heart failure10.1
33contact dermatitis10.1
34gastroenteritis10.1
35hypertension10.1
36influenza10.1
37ischemia10.1
38keratoconjunctivitis10.1
39periodontitis10.1
40pneumonia10.1
41pulmonary fibrosis10.1
42rheumatoid arthritis10.1
43stachybotrys chartarum10.1
44wells syndrome10.1
45pulmonary function10.1
46endotheliitis10.1
47mastocytosis10.1IGHE, IL13
48bronchiolitis10.1IL13, IGHE
49respiratory failure10.1IL13, IGHE
50schistosomiasis10.1IL13, IGHE

Graphical network of the top 20 diseases related to Allergic Asthma:



Diseases related to allergic asthma

Symptoms for Allergic Asthma

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Sources:
9Disease Ontology
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Symptoms:

9
  • chest tightness
  • shortness of breath or has_symptom rapid breathing
  • coughing
  • wheezing

Drugs & Therapeutics for Allergic Asthma

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Sources:
6CenterWatch, 43NIH Clinical Center, 7ClinicalTrials, 63UMLS, 42NDF-RT
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Approved drugs:

Search CenterWatch for Allergic Asthma

Drug clinical trials:

Search ClinicalTrials for Allergic Asthma

Search NIH Clinical Center for Allergic Asthma

Highlights from CenterWatch's Drugs in Clinical Trials Database for Allergic Asthma:

idCompanyCompoundMechanismPhase
1Rigel PharmaceuticalsR343An inhalation formulation of a small-molecule syk kinase inhibitorII

Genetic Tests for Allergic Asthma

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Anatomical Context for Allergic Asthma

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Sources:
34MalaCards
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MalaCards organs/tissues related to Allergic Asthma:

34
T cells, Lung, Smooth muscle, Skin, Testes, Monocytes, Bone, Heart, Breast, Myeloid, B cells, Endothelial, Bone marrow, Spleen

Animal Models for Allergic Asthma or affiliated genes

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Sources:
38MGI
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MGI Mouse Phenotypes related to Allergic Asthma:

38
idDescriptionMGI Source AccessionScoreTop Affiliating Genes
1MP:00053877.5IGHE, FCER1A, MS4A2, CCL24, CCL25, IL25
2MP:00053977.2IGHE, FCER1A, MS4A2, CCL24, CCL25, IL25

Publications for Allergic Asthma

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Sources:
53PubMed
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Articles related to Allergic Asthma:

(show top 50)    (show all 641)
idTitleAuthorsYear
1
Effects of taraxasterol on ovalbumin-induced allergic asthma in mice. (23727181)
2013
2
Roles of histone hypoacetylation in LAT expression on T cells and Th2 polarization in allergic asthma. (23360572)
2013
3
Anaphylatoxins coordinate innate and adaptive immune responses in allergic asthma. (23694705)
2013
4
Bone marrow mononuclear cell therapy in experimental allergic asthma: intratracheal versus intravenous administration. (23164835)
2013
5
Experimental model of allergic asthma. (22836618)
2013
6
The eXpeRience registry: the 'real-world' effectiveness of omalizumab in allergic asthma. (23721684)
2013
7
Concomitant asthma medications in moderate-to-severe allergic asthma treated with omalizumab. (23083840)
2013
8
Anti-asthmatic Effects of Baicalin in a Mouse Model of Allergic Asthma. (23580257)
2013
9
Xiao-Qing-Long-Tang shows preventive effect of asthma in an allergic asthma mouse model through neurotrophin regulation. (24010817)
2013
10
Phenotypic characterization of ex vivo CD4+CD25highCD127low immune regulatory T cells in allergic asthma: pathogenesis relevance of their FoxP3, GITR, CTLA-4 and FAS expressions. (23241113)
2012
11
The single nucleotide polymorphism CRTh2 rs533116 is associated with allergic asthma and increased expression of CRTh2. (22947041)
2012
12
The effects of (A+)-Praeruptorin A on airway inflammation, remodeling and transforming growth factor-I^1/Smad signaling pathway in a murine model of allergic asthma. (22974581)
2012
13
Crude extracts of Caenorhabditis elegans suppress airway inflammation in a murine model of allergic asthma. (22558152)
2012
14
A study on indoor environment contaminants related to dust mite in dwellings of allergic asthma patients and of healthy subjects. (22426097)
2012
15
Association of allergic asthma emergency room visits with the main biological and chemical air pollutants. (22750174)
2012
16
Low frequency of CD8+CD25+FOXP3(BRIGHT) T cells and FOXP3 mRNA expression in the peripheral blood of allergic asthma patients. (22824748)
2012
17
Different effects of farrerol on an OVA-induced allergic asthma and LPS-induced acute lung injury. (22563373)
2012
18
Pooled genome-wide analysis to identify novel risk loci for pediatric allergic asthma. (21359210)
2011
19
Cigarette smoke exacerbates mouse allergic asthma through Smad proteins expressed in mast cells. (21496353)
2011
20
Naringenin chalcone suppresses allergic asthma by inhibiting the type-2 function of CD4 T cells. (20035147)
2010
21
Omalizumab reduces oral corticosteroid use in patients with severe allergic asthma: real-life data. (20599369)
2010
22
Pharmacology and immunological actions of a herbal medicine ASHMI on allergic asthma. (19998324)
2010
23
Th2 LCR is essential for regulation of Th2 cytokine genes and for pathogenesis of allergic asthma. (20483988)
2010
24
A complex role for complement in allergic asthma. (20402389)
2010
25
Obesity enhances eosinophilic inflammation in a murine model of allergic asthma. (20100278)
2010
26
In vivo disruption of TGF-beta signaling by Smad7 in airway epithelium alleviates allergic asthma but aggravates lung carcinogenesis in mouse. (20405019)
2010
27
Anti-IgE therapy with omalizumab decreases endothelin-1 in exhaled breath condensate of patients with severe persistent allergic asthma. (20588001)
2010
28
Low dose oral administration of cytokines for treatment of allergic asthma. (19464382)
2009
29
Simultaneous occurrence of chronic autoimmune urticaria and non-allergic asthma: a common mechanism? (19585861)
2009
30
Early activation of coagulation after allergen challenge in patients with allergic asthma. (19552679)
2009
31
Expression of survivin in lung eosinophils is associated with pathology in a mouse model of allergic asthma. (19395375)
2009
32
The relationship between the haplotype of T cells immunoglobulin mucin-3 gene and allergic asthma in the Han population from Hubei province of China]. (18785518)
2008
33
Analysis of -675 4 g/5 G SERPINE1 and C-159T CD14 polymorphisms in house dust mite-allergic asthma patients. (18714537)
2008
34
Sex-related splenocyte function in a murine model of allergic asthma. (18498415)
2008
35
Maternal tolerance achieved during pregnancy is transferred to the offspring via breast milk and persistently protects the offspring from allergic asthma. (18778271)
2008
36
Macrophage migration inhibitory factor is essential for allergic asthma but not for Th2 differentiation. (17373669)
2007
37
Study on relationship between polymorphism sites of TIM4 and allergic asthma in the population of Han nationality from Hubei province of China]. (17407086)
2007
38
Study on the association of single nucleotide polymorphisms and haplotypes of GPR154 gene with allergic asthma in Han nationality in Hubei Chinese population]. (17285544)
2007
39
Blocking IL-25 prevents airway hyperresponsiveness in allergic asthma. (17889290)
2007
40
Histamine 4 receptor activation induces recruitment of FoxP3+ T cells and inhibits allergic asthma in a murine model. (17548646)
2007
41
Modeling the airway epithelium in allergic asthma: interleukin-13- induced effects in differentiated murine tracheal epithelial cells. (16223336)
2005
42
Altered intracellular expression of the chemokines MIP-1alpha, MIP-1beta and IL-8 by peripheral blood CD4+ and CD8+ T cells in mild allergic asthma. (12653799)
2003
43
Anti-immunoglobulin E (omalizumab) therapy in allergic asthma. (11704612)
2001
44
Proinflammatory cytokines (IL-17, IL-6, IL-18 and IL-12) and Th cytokines (IFN-gamma, IL-4, IL-10 and IL-13) in patients with allergic asthma. (11529906)
2001
45
Effect of interleukin-16-blocking peptide on parameters of allergic asthma in a murine model. (10585533)
1999
46
Differential effects of endogenous and exogenous interferon-gamma on immunoglobulin E, cellular infiltration, and airway responsiveness in a murine model of allergic asthma. (9806748)
1998
47
Immunohistochemical characterization of the cellular infiltrate in airway mucosa of toluene diisocyanate (TDI)-induced asthma: comparison with allergic asthma. (9539314)
1998
48
Allergen-induced CD23 on CD4+ T lymphocytes and CD21 on B lymphocytes in patients with allergic asthma: evidence and regulation. (7910139)
1994
49
Anti-IgE autoantibodies in asthma: a diagnostic artefact or an explanation for non-allergic asthma? (8171227)
1994
50
Influence of allergen avoidance at high altitude on serum markers of eosinophil activation in children with allergic asthma. (10779296)
1993

Variations for Allergic Asthma

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Expression for genes affiliated with Allergic Asthma

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Sources:
2BioGPS, 16Gene Expression Omnibus DataSets
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Expression patterns in normal tissues for genes affiliated with Allergic Asthma

Search GEO for disease gene expression data for Allergic Asthma.

Pathways for genes affiliated with Allergic Asthma

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Sources:
51PathCards, 39NCBI BioSystems Database, 56Reactome, 61Thomson Reuters, 55R&D Systems, 31KEGG, 54QIAGEN
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Pathways related to Allergic Asthma according to GeneCards/GeneDecks:

(show all 13)
idSuper pathways (with members indented)ScoreTop Affiliating Genes
19.9TBX21, IL13
2
Show member pathways
9.5MS4A2, IGHE, FCER1A
3
Show member pathways
Immune response T cell receptor signaling pathway61
Immune response CD28 signaling61
Immune response ICOS pathway in T helper cell61
9.5IGHE, MS4A2, FCER1A
4
Show member pathways
Immune response BCR pathway61
Fc-epsilon receptor I signaling in mast cells39
9.3IGHE, MS4A2, IL13, FCER1A
5
Show member pathways
9.0FCER1A, MS4A2, CCL25, IL13
6
Show member pathways
8.0CCL24, CCL27, CCL25, CCL18
7
Show member pathways
8.0CCL27, CCL25, CCL24, CCL18
8
Show member pathways
8.0CCL18, CCL25, CCL27, CCL24
9
Show member pathways
7.7CCL24, CCL18, CCL25, CCL27, IL13
10
Show member pathways
7.7IL13, CCL25, CCL18, CCL24, CCL27
11
Show member pathways
7.7CCL24, CCL18, CCL25, CCL27, IL13
12
Show member pathways
7.4FCER1A, CCL24, CCL18, CCL25, IL13, CCL27
13
Show member pathways
7.1CCL18, CCL25, FCER1A, CCL24, IL13, IL25

Compounds for genes affiliated with Allergic Asthma

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Sources:
46Novoseek, 12DrugBank, 52PharmGKB, 30IUPHAR, 25HMDB, 62Tocris Bioscience
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Compounds related to Allergic Asthma according to GeneCards/GeneDecks:

(show all 27)
idCompoundScoreTop Affiliating Genes
1scca14610.2SERPINB4, IL13
2trimellitic anhydride4610.2IL13, IGHE
3methyltetrahydrophthalic anhydride4610.2IGHE, IL13
4ovomucoid4610.2IL13, IGHE
5desloratadine46 1211.2IGHE, IL13
6praziquantel46 1211.1IL13, IGHE
7penicillin4610.1IL13, IGHE
8montelukast46 52 30 1213.1IL13, IGHE
9mycophenolic acid46 52 1212.1IGHE, IL13
10budesonide46 52 1212.1IL13, IGHE
11salbutamol46 52 30 25 1214.1IGHE, IL13
12fluticasone propionate46 52 62 1213.0IGHE, IL13
13pgd24610.0IL13, IGHE
14methacholine46 52 1211.9IL13, IGHE
15omalizumab46 1210.7IL13, MS4A2, FCER1A, IGHE
16acetylcholine46 52 30 25 1213.5IGHE, IL13, CD160
17cyclosporin a46 30 6211.4CD160, IL13, IGHE
18capsaicin46 3010.4CD160, IGHE
19actinomycin d469.2IGHE, CCL24, IL13
20ccl446 3010.2IL13, CCL27, CCL18
21allergens469.1IGHE, MS4A2, CCL27, IL13
22histamine46 30 2511.0IGHE, FCER1A, CCL24, IL13, CD160
23dexamethasone46 52 30 1211.7IL13, CCL27, CCL18, IGHE
24ccl346 309.7CCL24, CCL18, CCL27, IL13
25alanine468.7IL13, CCL27, CCL18, IGHE
26tarc468.4IGHE, CCL24, CCL18, CCL27, IL13
27rantes468.1IL13, CCL27, CCL25, CCL18, CCL24

GO Terms for genes affiliated with Allergic Asthma

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Sources:
17Gene Ontology
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Cellular components related to Allergic Asthma according to GeneCards/GeneDecks:

idNameGO IDScoreTop Affiliating Genes
1external side of plasma membraneGO:0098979.7IL13, MS4A2, FCER1A
2extracellular regionGO:0055767.3GZMK, IGHE, SERPINB4, CCL25, CCL27, IL13
3extracellular spaceGO:0056157.0CCL27, SERPINB4, CCL24, CCL18, CCL25, IL13

Biological processes related to Allergic Asthma according to GeneCards/GeneDecks:

(show all 7)
idNameGO IDScoreTop Affiliating Genes
1positive regulation of mast cell degranulationGO:0433069.6MS4A2, FCER1A
2Fc-epsilon receptor signaling pathwayGO:0380959.5MS4A2, FCER1A, IGHE
3cell chemotaxisGO:0603268.5CCL27, CCL25, CCL18
4inflammatory responseGO:0069548.4MS4A2, CCL24, CCL18, CCL25, IL13
5cell-cell signalingGO:0072678.3CCL24, CCL18, CCL27, IL13
6chemotaxisGO:0069358.1CCL24, CCL18, CCL25, CCL27
7immune responseGO:0069557.2IL13, CCL27, CCL25, CCL18, CCL24, MS4A2

Molecular functions related to Allergic Asthma according to GeneCards/GeneDecks:

idNameGO IDScoreTop Affiliating Genes
1IgE bindingGO:0198639.9MS4A2, FCER1A
2chemokine activityGO:0080097.7CCL27, CCL25, CCL18, CCL24

Products for genes affiliated with Allergic Asthma

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  • Antibodies
  • Proteins
  • Lysates
  • Antibodies

Sources for Allergic Asthma

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4CDC
14ExPASy
15FMA
23GTR
24HGMD
25HMDB
26ICD10
27ICD10 via Orphanet
28ICD9CM
30IUPHAR
31KEGG
36MeSH
37MESH via Orphanet
38MGI
41NCIt
42NDF-RT
45NINDS
46Novoseek
48OMIM
49OMIM via Orphanet
53PubMed
54QIAGEN
60SNOMED-CT via Orphanet
63UMLS
64UMLS via Orphanet