Allergic Asthma malady

Disease Ontology: An asthma that is characterized by symptoms that are triggered by an allergic reaction caused by inhaled allergens such as dust mite allergen, pet dander, pollen and mold. allergic asthma is airway obstruction and inflammation that is partially reversible with medication. the disease has symptom coughing, has symptom wheezing, has symptom shortness of breath or has symptom rapid breathing, and has symptom chest tightness.⁶

MalaCards: Allergic Asthma, also known as extrinsic asthma with status asthmaticus (disorder), is related to asthma and atopy, and has symptoms including coughing, wheezing and shortness of breath or has_symptom rapid breathing. An important gene associated with Allergic Asthma is GZMK (granzyme K (granzyme 3; tryptase II)), and among its related pathways are Lymphocyte Signaling and Chemokine signaling pathway. The drugs metaproterenol and ephedrine sulfate and the compounds cyclophosphamide and budesonide have been mentioned in the context of this disorder. Affiliated tissues include spleen, heart and lung, and related mouse phenotypes are respiratory system and renal/urinary system.

Aliases & Descriptions:

allergic asthma 6 43 extrinsic asthma with status asthmaticus (disorder) 6 extrinsic asthma with status asthmaticus 6

extrinsic asthma with acute exacerbation 6 asthma allergic 32 asthma 43

Diseases related to allergic asthma by text searches and GeneDecks gene sharing:

(show top 50)    (show all 898)

id	Related Disease	Score	Top Affiliating Genes
1	asthma	40.0	SCGB1A1, IL13, CCL11, HNMT, TNF, PLA2G7
2	atopy	37.0	MS4A2, IL4R, PLA2G7
3	bronchitis	33.6	IL5, IL8, CCL11, IGHE, RNASE3, SLPI
4	cough variant asthma	33.3	IL10, IL4, IL5, IGHE, RNASE3
5	intrinsic asthma	32.3	IL3, IL4, IL5, CCL5, IGHE, RNASE3
6	allergic rhinitis	31.4	VCAM1, IL13, IL4, IL5, IGHE, RNASE3
7	status asthmaticus	30.4	IL5, IL8, CCL11, RNASE3, TGFB1, ADRB2
8	chronic eosinophilic pneumonia	30.1	IL5, CCL11, RNASE3
9	allergic bronchopulmonary aspergillosis	29.9	IL4, IL5, IGHE
10	bronchial asthma	29.8	PDE3B, SERPINB4, VCAM1, BDNF, SCGB1A1, MS4A2
11	congestive heart failure	29.7	PDE3B, UCN, PPBP, EDN1, AGTR1, ADRB2
12	arthritis	29.6	IL17A, IL1A, IL6, IL8, TNF
13	food allergy	29.5	FOXP3, IL13, IL4, IL5, CCL11, IGHE
14	churg-strauss syndrome	29.5	IL10, IL13, IL2, IL25, IL2RA, IL4
15	rheumatoid arthritis	29.2	MIF, IL10, IL2, HLA-DRB1, TRA@, TNF
16	eosinophilic pneumonia	29.2	CD69, IL13, IL3, IL5, CCL22, CCL11
17	obstructive lung disease	29.1	IGHE, CXCR3, ADRB2
18	sepsis	29.0	CD14, IL10, TNF
19	tuberculosis	29.0	CISH, CD209, IL10, IL4, IFNG, TNF
20	vernal keratoconjunctivitis	29.0	VCAM1, IL13, IL3, IL4, IL5, IL8
21	b-cell lymphomas	28.6	BCL2, CD14, CD80, ITGAL, GZMB, IL16
22	kimura disease	28.0	IL13, IL4, IL5, CCL11, IGHE, RNASE3
23	hypereosinophilic syndrome	28.0	CD69, IL13, IL2, IL2RA, IL3, IL5
24	glucocorticoid resistance	27.8	BCL2, CD28, MIF, IL10, IL1A, IL2
25	toxocariasis	27.5	CD40LG, IGHE, RNASE3
26	common cold	27.4	IL5, IL8, CCL11, RNASE3
27	pulmonary function	27.2	CD14, IL10, IL13, IL16, IL18, IL4
28	glioblastoma	27.2	CD80, FLT3LG, IL13, IL4R, ALOX5, NTRK1
29	bronchiectasis	27.2	CD14, CD4, IL10, IL6, IL8, IGHE
30	cortisol resistance	26.9	IL10, IL4, IL6, IGHE
31	gamma chain deficiency	26.9	IL13, IL18R1, IL2, IL2RA, IL2RB, IL4
32	mastocytosis	26.7	BCL2, CD69, IL13, IL2RA, IL3, IL5
33	interleukin receptor	26.5	IL10, IL4, IL4R, IL5, IL6, NGF
34	eczema	26.4	MS4A2, CD14, CD40LG, ITK, FOXP3, FCER1A
35	panniculitis	26.3	GZMB, IL2RA, IL2RB, IGHE, IFNG, F3
36	pulmonary emphysema	26.3	IL18, IL8, ANXA5, IFNG, NOS3, RNASE3
37	blindness	26.1	SERPINE1, CD40LG, ITGAL, IL10, IL18, IL1A
38	keratoconjunctivitis	25.9	VCAM1, CD86, CD4, CD80, IL13, IL1A
39	acute chest syndrome	25.9	VCAM1, IL8, HLA-DQB1, HLA-DRB1, NOS3, EDN1
40	chronic obstructive pulmonary disease	25.7	SCGB1A1, CD80, GZMB, IL13, IL16, IL17A
41	eosinophilia	25.6	PDE3B, VCAM1, LGALS9, CISH, MS4A2, CD69
42	hyper-ige syndrome	25.4	IL10, IL13, IL17A, IL4, IL4R, IL6
43	alpha 1-antitrypsin deficiency	25.3	SERPINE1, BMP6, CD14, IL10, IL8, IGHE
44	copd	25.1	SERPINE1, BMP6, BCL2, SCGB1A1, LBP, CD69
45	microscopic polyangiitis	25.1	IL10, IL2RA, HLA-DQB1, HLA-DRB1, TNF, CTLA4
46	atopic dermatitis	25.0	VCAM1, BDNF, MS4A2, CD69, CD86, CD14
47	aspergillosis	24.6	CD209, CD4, IL10, IL17A, IL1A, IL2RA
48	emphysema	24.6	SERPINE1, BMP6, SCGB1A1, IL13, IL18, IL5
49	t-cell leukemia	24.5	BCL2, CD209, CD28, CD4, ITGAL, FOXP3
50	urticaria	24.3	VCAM1, MS4A2, CD40LG, GZMB, FCER1A, IL10

Symptoms: coughing, wheezing, shortness of breath or has_symptom rapid breathing, chest tightness.⁶

Approved drugs:

Drug clinical trials:

Inferred drug relations via UMLS/NDF-RT:

^43 28 [re100] antiasthma/bronchodilators, [re101] anti-inflammatories,inhalation, [re102] bronchodilators,sympathomimetic,inhalation, [re103] bronchodilators,sympathomimetic,oral, [re104] bronchodilators,xanthine-derivative, [re105] bronchodilators,anticholinergic, [re108] antiasthma,antileukotrienes, [re109] antiasthma,other, albuterol, albuterol so4 pwdr [va product], albuterol sulfate, aminophylline, aminophylline dihydrate, aminophylline pwdr [va product], ephedra, ephedrine, ephedrine hydrochloride, ephedrine sulfate, ephedrine tannate, glycerol,iodinated, isoetharine, isoetharine hydrochloride, isoetharine mesylate, metaproterenol, metaproterenol sulfate, montelukast, montelukast sodium, oleandomycin (as troleandomycin), oxtriphylline, pirbuterol, pirbuterol acetate, pseudoephedrine, pseudoephedrine hydrochloride, pseudoephedrine sulfate, terbutaline, terbutaline sulfate, theophylline, theophylline calcium salicylate, theophylline sodium glycinate, theophylline,anhydrous

MalaCards organs/tissues related to allergic asthma:

²²

MGI Mouse Phenotypes related to allergic asthma:

²⁵ (show all 23)

id	Description	MGI Source Accession	Score	Top Affiliating Genes
1	respiratory system phenotype	MP:0005388	10.3	SCGB1A1, BDNF, CD14, ARRB2, IL25, MYH11
2	renal/urinary system phenotype	MP:0005367	9.6	MYH11, GATA3, SOCS1, AHR, AGTR1, NGFR
3	no phenotypic analysis	MP:0003012	9.4	AICDA, TRG@, NTRK1, AHR, TIMELESS, SYK
4	endocrine/exocrine gland phenotype	MP:0005379	9.3	DPP4, TLR2, NR6A1, CTLA4, IFNG, IL2RB
5	hematopoietic system phenotype	MP:0005397	8.7	CSF2, CCR4, IL5, IL4R, IL33, IL3
6	skeleton phenotype	MP:0005390	8.5	PLAU, SYK, STAT1, CSF2, C5AR1, GATA3
7	liver/biliary system phenotype	MP:0005370	8.2	NOS3, NGFR, AHR, TLR2, TLR4, SYK
8	integument phenotype	MP:0010771	7.8	NGFR, NGF, NTRK1, CTLA4, TRB@, AHR
9	reproductive system phenotype	MP:0005389	7.7	NR6A1, TLR4, TGFB1, STAT6, SOCS1, CSF2
10	normal phenotype	MP:0002873	7.6	TRG@, TRB@, TPT1, CTLA4, NTRK1, NGFR
11	digestive/alimentary phenotype	MP:0005381	7.0	MYH11, SOCS1, CX3CR1, STAT1, TGFB1, TLR2
12	adipose tissue phenotype	MP:0005375	6.6	NOS3, TLR2, TLR4, TGFB1, CSF2, ADRB2
13	behavior/neurological phenotype	MP:0005386	6.5	NGF, NOS3, NTRK1, HLA-DQB1, F3, NGFR
14	nervous system phenotype	MP:0003631	6.4	PLAU, NGF, EDN1, TLR2, TLR4, TGFB1
15	immune system phenotype	MP:0005387	6.3	CCL3, CCL25, IL6, IL33, IL2, ARRB2
16	vision/eye phenotype	MP:0005391	6.1	NOS3, NGF, NGFR, AHR, TLR4, TGFB1
17	muscle phenotype	MP:0005369	5.7	EDN1, AHR, TLR2, TGFB1, STAT1, CX3CR1
18	tumorigenesis	MP:0002006	5.4	AHR, PLAU, TBX21, TNF, TRB@, TLR2
19	growth/size phenotype	MP:0005378	5.3	AGTR1, NGFR, NGF, NOS3, PLAU, NTRK1
20	mortality/aging	MP:0010768	5.0	PLAU, NR6A1, NTRK1, CTLA4, PTPN22, TPT1
21	homeostasis/metabolism phenotype	MP:0005376	4.2	CXCR3, CX3CR1, CX3CL1, STAT1, STAT6, SYK
22	cardiovascular system phenotype	MP:0005385	3.9	TGFB1, TLR4, TLR2, AHR, AGTR1, EDN1
23	cellular phenotype	MP:0005384	2.3	TRB@, IL18, IL13, IL10, ARRB2, MIF

Articles related to allergic asthma:

(show top 50)    (show all 180)

id	Title	Authors	Year	Affiliating Genes
1	Association of childhood allergic asthma with markers flanking the IL33 gene in Italian families. (21802127)	Belpinati F.... Pignatti P.F.	2011	IL33
2	Increased expression of aryl hydrocarbon receptor and interleukin 22 in patients with allergic asthma. (22053597)	Zhu J.... Xiong S.	2011	AHR, IL22
3	Mite allergen decreases DC-SIGN expression and modula tes human dendritic cell differentiation and function in allergic asthma. (21471959)	Huang H.J.... Wang J.Y.	2011	CD209
4	Association between reduced copy-number at T-cell rec eptor gamma (TCRgamma) and childhood allergic asthma: A possible role for somat ic mosaicism. (20553737)	Walsh K.M.... DeWan A.T.	2010	TRB@, TRA@, TRG@
5	Pulmonary suppressor of cytokine signaling-1 induced by IL-13 regulates allergic asthma phenotype. (19299500)	Fukuyama S.... Inoue H.	2009	SOCS1, IL13, CISH
6	Association of ADAM33 gene polymorphisms with adult allergic asthma and rhinitis in a Chinese Han population. (18778489)	Su D.... Zhang J.	2008	ADAM33
7	The functional insufficiency of human CD4+CD25 high T-regulatory cells in allergic asthma is subjected to TNF-alpha modulation. (18053016)	Lin Y.L.... Wang J.Y.	2008	FOXP3
8	Association of PTPN22 single nucleotide polymorphism with rheumatoid arthritis but not with allergic asthma. (17579671)	Majorczyk E.... Kusnierczyk P.	2007	PTPN22
9	Association of the expression of IL-4 and IL-13 genes, IL-4 and IgE serum levels with allergic asthma. (17563406)	Tavakkol Afshari J.... Ghasemi G.	2007	IL4, IL13, IGHE
10	A recombinant humanized anti-IgE monoclonal antibody (omalizumab) in the therapy of moderate-to-severe allergic asthma. (19075985)	D'Amato G.... Liccardi G.	2007	IGHE
11	Macrophage migration inhibitory factor is essential for allergic asthma but not for Th2 differentiation. (17373669)	MagalhALes E.S.... Bozza M.T.	2007	MIF
12	Increased expression of plasma and CD4+ T lymphocyte costimulatory molecule CD26 in adult patients with allergic asthma. (17525828)	Lun S.W.... Lam C.W.	2007	DPP4
13	Active immunotherapy of allergic asthma with a recombinant human interleukin-5 protein as vaccine in a murine model. (17908461)	Tan G.H.... Lin Y.Y.	2007	IL5
14	Omalizumab decreased IgE-release and induced changes in cellular immunity in patients with allergic asthma. (16918520)	Hanf G.... Noga O.	2006	IGHE
15	The research on the correlation between eotaxin-3 gene polymorphisms and allergic asthma (16604488)	Gao G.M.... He Z.Q.	2006	CCL26
16	Allergic asthma and intrinsic inhibitors of cytokine signaling (16671324)	Inoue H.	2006	IL4, IL13, IL5
17	Gene expression analysis in a murine model of allergic asthma reveals overlapping disease and therapy dependent pathways in the lung. (16402082)	Follettie M.T.... Wills-Karp M.	2006	IL13
18	Inhibitory effects of fluvastatin on cytokine and chemokine production by peripheral blood mononuclear cells in patients with allergic asthma. (16630152)	Samson K.T.... Adachi M.	2006	CXCL10
19	Treating Moderate-to-Severe Allergic Asthma with a Recombinant Humanized Anti-IgE Monoclonal Antibody (Omalizumab). (17154668)	D'Amato G.... Canonica W.	2006	IGHE
20	The role of the FOXP3 transcription factor in the immune regulation of allergic asthma. (16091206)	Schmidt-Weber C.B.... Blaser K.	2005	FOXP3
21	TNF-alpha and IL-8 of the patients with allergic asthma. (16201269)	Liu G.... Li B.	2005	IL8
22	Arthropod-derived protein EV131 inhibits histamine ac tion and allergic asthma. (16387687)	Weston-Davies W.... Ryffel B.	2005	IL5
23	Increased expression of plasma and cell surface co-stimulatory molecules CTLA-4, CD28 and CD86 in adult patients with allergic asthma. (15958078)	Wong C.K.... Lam C.W.	2005	CD86, CTLA4
24	Modeling the airway epithelium in allergic asthma: interleukin-13- induced effects in differentiated murine tracheal epithelial cells. (16223336)	Lankford S.M.... Martin L.D.	2005	IL13
25	Spleen tyrosine kinase (Syk) as a novel target for allergic asthma and rhinitis. (16185147)	Ulanova M.... Befus A.D.	2005	SYK
26	Neurotrophins and neurotrophin receptors in allergic asthma. (14699973)	Nassenstein C.... Braun A.	2004	NGFR
27	The potential use of Chinese herbal medicines in trea ting allergic asthma. (15330010)	Li X.M.... Schofield B.	2004	GATA3
28	Cytotoxic T lymphocyte antigen 4 polymorphisms and allergic asthma. (14720255)	Van Oosterhout A.J.... Groot P.C.	2004	CTLA4
29	Allergic asthma and interleukins 2, 4, 5, 6 and 12 and gamma interferon levels (15314841)	Bastida Segura D.L.... Miranda Feria A.J.	2004	IFNG
30	Altered intracellular expression of the chemokines MIP-1alpha, MIP-1beta and IL-8 by peripheral blood CD4+ and CD8+ T cells in mild allergic asthma. (12653799)	Grob M.... Bisset L.R.	2003	IL8, IL4, CCL5
31	Inhibition of the IL-4/IL-13 receptor system prevents allergic sensitization without affecting established allergy in a mouse model for allergic asthma. (12789240)	Hahn C.... Grunewald S.M.	2003	IL4, IL5
32	Beta-arrestin-2 regulates the development of allergic asthma. (12925697)	Walker J.K.... Lefkowitz R.J.	2003	ARRB2
33	Correlation analysis of CD40L expression of peripheral T lymphocytes and serum level of IgE in children with allergic asthma (14759330)	Zhang X.Y.... Guo L.	2003	IGHE
34	HLA class II genotypic frequencies in atopic asthma: association of DRB1*01-DQB1*0501 genotype with Artemisia vulgaris allergic asthma. (12878360)	Torio A.... Alvarez-Lopez M.R.	2003	HLA-DQB1, HLA-DRB1
35	In allergic asthma experimental exposure to allergens is associated with depletion of blood eosinophils overexpressing LFA-1. (12359000)	Lantero S.... Rossi G.A.	2002	ITGAL
36	V75R576 IL-4 receptor alpha is associated with allergic asthma and enhanced IL-4 receptor function. (12133990)	Risma K.A.... Hershey G.K.	2002	IL4R
37	In vitro effect of fluticasone propionate on interleukin 8 production by monocytes obtained from patients affected by moderate-severe allergic asthma. (12207111)	Gangemi S.... Alba Merendino R.	2002	IL8
38	Up-regulation of interferon-gamma production by reduced glutathione, anthocyane and L-cysteine treatment in children with allergic asthma and recurrent respiratory diseases. (12687266)	Chernyshov V.P.... Zelinsky G.M.	2002	IL4, IFNG, IGHE
39	Proinflammatory cytokines (IL-17, IL-6, IL-18 and IL-12) and Th cytokines (IFN-gamma, IL-4, IL-10 and IL-13) in patients with allergic asthma. (11529906)	Wong C.K.... Lam C.W.	2001	IL18, IL4, IFNG
40	The NK-2 receptor antagonist SR 48968C does not improve adenosine hyperresponsiveness and airway obstruction in allergic asthma. (11251629)	Kraan J.... Postma D.S.	2001	TACR2, CD160
41	Identification of complement factor 5 as a susceptibility locus for experimental allergic asthma. (10973279)	Karp C.L.... Wills-Karp M.	2000	C5AR1
42	IL-10 induces a Th2 cell tolerance in allergic asthma. (10224456)	Adachi M.... Minoguchi K.	1999	IL10
43	Interleukin-13: central mediator of allergic asthma. (9856949)	Wills-Karp M.... Donaldson D.D.	1998	IL4, IL13, IL5
44	The role of IL-13 in IgE synthesis by allergic asthma patients. (9472672)	van der Pouw Kraan T.C.... Aarden L.A.	1998	IL4, IL13, IGHE
45	Differential effects of endogenous and exogenous interferon-gamma on immunoglobulin E, cellular infiltration, and airway responsiveness in a murine model of allergic asthma. (9806748)	Hofstra C.L.... Van Oosterhout A.J.	1998	IFNG
46	Anti-IgE autoantibodies in asthma: a diagnostic artefact or an explanation for non-allergic asthma? (8171227)	Stadler B.M.	1994	IGHE
47	Upregulation of formyl-peptide and interleukin-8-induced eosinophil chemotaxis in patients with allergic asthma. (8509580)	Warringa R.A.... Koenderman L.	1993	IL3
48	Antigen avoidance in a mountain environment: influence on basophil releasability in children with allergic asthma. (7693784)	Piacentini G.L.... Boner A.L.	1993	IGHE
49	Comparative studies on cyclic nucleotide phosphodiesterases and inhibitors in experimental models of hypertension, congestive heart failure, and allergic asthma. (1313266)	Silver P.J.... Pagani E.D.	1992	PDE3B
50	Autoantibodies to beta 2-adrenergic receptors with antiadrenergic activity from patients with allergic asthma. (1655856)	Wallukat G.... Wollenberger A.	1991	ADRB2

Genes related to allergic asthma according to GeneCards:

(show top 50)    (show all 131)

id	Symbol	Description	Score	GeneCards Section Context
1	GZMK	granzyme K (granzyme 3; tryptase II)	11.0	Publications
2	IL25	interleukin 25	11.0	Publications
3	RNASE2	ribonuclease, RNase A family, 2 (liver, eosinophil-derived neurotoxin)	11.0	Publications
4	IGHE	immunoglobulin heavy constant epsilon	11.0	Publications
5	FCER1A	Fc fragment of IgE, high affinity I, receptor for; alpha polypeptide	11.0	Publications
6	SERPINB4	serpin peptidase inhibitor, clade B (ovalbumin), member 4	11.0	Publications
7	TBX21	T-box 21	11.0	Publications
8	TRG@	T cell receptor gamma locus	11.0	Publications
9	HAVCR2	hepatitis A virus cellular receptor 2	11.0	Publications
10	TPT1	tumor protein, translationally-controlled 1	11.0	Publications
11	IL13	interleukin 13	11.0	Publications
12	MS4A2	membrane-spanning 4-domains, subfamily A, member 2	11.0	Publications
13	LGALS9	lectin, galactoside-binding, soluble, 9	11.0	Publications
14	CD160	CD160 molecule	11.0	Publications
15	CCL24	chemokine (C-C motif) ligand 24	11.0	Publications
16	IL22	interleukin 22	11.0	Publications
17	IL17D	interleukin 17D	11.0	Publications
18	CISH	cytokine inducible SH2-containing protein	11.0	Publications
19	NPSR1	neuropeptide S receptor 1	11.0	Publications
20	CCL26	chemokine (C-C motif) ligand 26	11.0	Publications
21	CCL25	chemokine (C-C motif) ligand 25	11.0	Publications
22	SERPINB3	serpin peptidase inhibitor, clade B (ovalbumin), member 3	11.0	Publications
23	ADAM33	ADAM metallopeptidase domain 33	11.0	Publications
24	TIMD4	T-cell immunoglobulin and mucin domain containing 4	11.0	Publications
25	UCN	urocortin	11.0	Publications
26	CCL18	chemokine (C-C motif) ligand 18 (pulmonary and activation-regulated)	11.0	Publications
27	XCL1	chemokine (C motif) ligand 1	11.0	Publications
28	FLT3LG	fms-related tyrosine kinase 3 ligand	11.0	Publications
29	FCAR	Fc fragment of IgA, receptor for	11.0	Publications
30	HNMT	histamine N-methyltransferase	11.0	Publications
31	HAVCR1	hepatitis A virus cellular receptor 1	11.0	Publications
32	TIMELESS	timeless homolog (Drosophila)	11.0	Publications
33	FOXP3	forkhead box P3	11.0	Publications
34	STAT6	signal transducer and activator of transcription 6, interleukin-4 induced	11.0	Publications
35	ICOS	inducible T-cell co-stimulator	11.0	Publications
36	ITK	IL2-inducible T-cell kinase	11.0	Publications
37	IL5	interleukin 5 (colony-stimulating factor, eosinophil)	11.0	Publications
38	IL33	interleukin 33	11.0	Publications
39	PITRM1	pitrilysin metallopeptidase 1	11.0	Publications
40	PPBP	pro-platelet basic protein (chemokine (C-X-C motif) ligand 7)	11.0	Publications
41	SCGB1A1	secretoglobin, family 1A, member 1 (uteroglobin)	11.0	Publications
42	GATA3	GATA binding protein 3	11.0	Publications
43	SPINT2	serine peptidase inhibitor, Kunitz type, 2	11.0	Publications
44	EPX	eosinophil peroxidase	11.0	Publications
45	AICDA	activation-induced cytidine deaminase	11.0	Publications
46	ABP1	amiloride binding protein 1 (amine oxidase (copper-containing))	11.0	Publications
47	CCL22	chemokine (C-C motif) ligand 22	11.0	Publications
48	CCR4	chemokine (C-C motif) receptor 4	11.0	Publications
49	ARRB2	arrestin, beta 2	11.0	Publications
50	CCR9	chemokine (C-C motif) receptor 9	11.0	Publications

Pathways related to allergic asthma according to GeneDecks:

(show top 50)    (show all 161)

id	Pathway	Score	Top Affiliating Genes
1	Lymphocyte Signaling3	10.1	CD4, ITK, FOXP3, IL2RA, IL2RB, CARD11
2	Chemokine signaling pathway20	10.1	XCL1, ITK, ARRB2, IL8, CCL4, CCL26
3	Jak-STAT signaling pathway20	9.7	CISH, IL10, IL13, IL2, IL22, IL2RA
4	Graft-versus-host disease20	9.7	CD28, CD86, CD80, IL1A, IL2, HLA-DPB1
5	RAR-Gamma-RXR-Alpha Degradation36	9.7	CD80, IL16, IL2, IL22, IL3, CCL4
6	Transendothelial Migration of Leukocytes36	9.5	VCAM1, XCL1, ITGAL, ITK, IL8, CCL4
7	IL-6 Pathway36	9.3	BMP6, CD80, IL10, IL16, IL18, IL22
8	IL-15 Signaling and its Primary Biological Effects in Different Immune Cell Types37	9.2	BCL2, GZMB, IL2, IL2RA, IL2RB, CCL4
9	Asthma20	8.8	MS4A2, CD40LG, FCER1A, IL10, IL13, IL3
10	Autoimmune thyroid disease20	8.7	CD28, CD86, CD40LG, CD80, GZMB, IL10
11	Toll-like receptor signaling pathway20	8.5	LBP, CD86, CD14, CD80, IL6, IL8
12	Regulation of eIF4 and p70S6K36	8.4	CD4, CD80, ITGAL, IL13, IL16, IL18
13	NFAT Signaling and Lymphocyte Interactions36	8.3	BMP6, BCL2, CD4, CD80, FCER1A, IL13
14	Th1 Differentiation37	8.3	CD28, CD86, CD4, CD80, IL10, IL18
15	Endothelin-1 Signaling Pathway36	8.1	BMP6, CD80, IL10, IL13, IL16, IL18
16	THC Differentiation Pathway36	8.1	CD28, CD86, IL10, IL18, IL18R1, IL2
17	Type I diabetes mellitus20	8.0	CD28, CD86, CD80, GZMB, IL1A, IL2
18	PGC1Alpha Pathway36	7.9	BMP6, BCL2, CD4, CD80, IL13, IL16
19	Immune response IL-22 signaling pathway10	7.9	BCL2, CD28, CD86, CD4, IL2, IL22
20	Allograft rejection20	7.8	CD28, CD86, CD40LG, CD80, GZMB, IL10
21	Immune response_IL-22 signaling pathway41	7.8	BCL2, CD28, CD86, CD4, IL2, IL22
22	Hematopoietic cell lineage20	7.8	CD14, CD4, FLT3LG, IL1A, IL2RA, IL3
23	Cytokine Network36	7.8	IL10, IL13, IL16, IL18, IL1A, IL2
24	T cell receptor signaling pathway20	7.7	CD28, CD4, CD40LG, ITK, IL10, IL2
25	Intestinal immune network for IgA production20	7.5	CD28, CD86, CD40LG, CD80, IL10, IL2
26	Akt Signaling36	7.3	PDE3B, CD28, CD4, CD80, ITGAL, IL10
27	ERK Signaling36	7.3	BMP6, CD80, ITGAL, IL10, IL13, IL16
28	SOCS Pathway36	7.1	BMP6, BCL2, CISH, CD4, CD80, IL10
29	Molecular Mechanisms of Cancer36	6.9	BMP6, BDNF, BCL2, CD4, CD80, ITGAL
30	Malaria20	6.9	VCAM1, CD40LG, ITGAL, IL10, IL18, IL6
31	JNK Pathway36	6.9	BMP6, BCL2, CD4, CD80, IL18R1, IL2
32	all-trans-Retinoic Acid Signaling in Brain36	6.8	BMP6, BCL2, CD80, IL10, IL13, IL16
33	Rho Family GTPases36	6.8	BMP6, BDNF, BCL2, CD80, ITGAL, IL10
34	PEDF Induced Signaling36	6.7	BMP6, BDNF, BCL2, CD80, IL10, IL13
35	MIF Mediated Glucocorticoid Regulation36	6.6	BMP6, BCL2, CD14, CD80, MIF, IL10
36	MIF Regulation of Innate Immune Cells36	6.6	BMP6, BCL2, CD14, CD80, MIF, IL10
37	Toxoplasmosis20	6.5	BCL2, CD40LG, IL10, IFNG, ALOX5, HSPA1B
38	Rheumatoid arthritis20	6.2	CD28, CD86, CD80, ITGAL, IL17A, IL18
39	Tuberculosis20	6.1	BCL2, LBP, CD209, CD14, IL10, IL18
40	Glucocorticoid Receptor Signaling36	6.1	BMP6, BCL2, CD4, CD80, IL10, IL13
41	Cytokine-cytokine receptor interaction20	5.9	XCL1, CD40LG, FLT3LG, IL10, IL13, IL17A
42	STAT3 Pathway36	5.9	BMP6, BCL2, CD28, CD4, CD80, IL10
43	TGF-Beta Pathway36	5.9	BMP6, BDNF, BCL2, CD4, CD80, IL10
44	PAK Pathway36	5.5	BMP6, BDNF, BCL2, CD80, IL10, IL13
45	MAPK Family Pathway36	5.4	BMP6, BDNF, BCL2, CD4, CD80, IL10
46	JAK-STAT Pathway36	5.3	BMP6, BDNF, BCL2, CD4, CD80, IL10
47	p38 Signaling36	4.7	BMP6, BDNF, BCL2, CD28, CD4, CD80
48	Tec Kinases Signaling36	4.5	BMP6, BDNF, BCL2, CD28, CD4, CD80
49	Chemokine Signaling36	INF	XCL1, ARRB2, IL8, CCL4, CCL26, CCL22
50	Antioxidant Action of Vitamin-C36	INF	BMP6, BDNF, BCL2, CD28, CD4, CD80

Compounds related to allergic asthma according to GeneDecks:

(show top 50)    (show all 405)

id	Compound	Score	Top Affiliating Genes
1	cyclophosphamide32 34 9 9	13.6	ITGAL, FLT3LG, TRB@, CXCL9
2	budesonide32 42 9 9	13.5	CCL11, IGHE, RNASE3, CSF2, EPX
3	sp 60012532 42	11.4	VCAM1, IL13, IL17A, TLR2
4	ionomycin32	10.4	CD69, IL3, IL5, CCL4, CCL11, CCL3
5	isoproterenol32 9 9	11.7	PDE3B, ITGAL, ARRB2, IL13, IL1A, IL3
6	rapamycin32 42	10.5	BDNF, CD86, CD80, FOXP3, GZMB, IL18R1
7	montelukast32 34 9 9	12.5	IL10, IL13, IL2RA, IL4, IL5, IL8
8	methylcellulose32	9.3	CD14, FLT3LG, IL1A, IL3, IL4, IL5
9	h2o232	9.1	BDNF, ITGAL, MIF, IL13, IL18, IL2RA
10	fluticasone propionate32 42 9 9	12.0	VCAM1, IL13, IL16, IL4, IL5, IL8
11	epinephrine32 9 18 9	11.9	BMP6, BDNF, CD69, IL1A, CCL22, CCL5
12	theophylline32 9 18 9	11.8	PDE3B, CD40LG, ITGAL, IL10, IL13, IL16
13	heparin32 9 18 9	11.7	SERPINE1, LBP, XCL1, CD69, CD4, ITGAL
14	cysteine32	8.6	SERPINB4, XCL1, CD14, CD4, CD40LG, GZMB
15	mip 1alpha32	8.3	IL10, IL13, IL3, IL4, IL6, IL8
16	aspartate32	8.3	BMP6, BDNF, SCGB1A1, LBP, CD14, CD40LG
17	adenylate32	8.2	PDE3B, SERPINE1, VCAM1, BDNF, UCN, CD40LG
18	ifn-alpha32	8.0	CISH, IL10, IL13, IL17A, IL18, IL2
19	tarc32	7.9	CD4, IL10, IL13, IL18, IL1A, IL4
20	thapsigargin32 42	8.9	SERPINE1, BDNF, BCL2, CISH, CD69, ITGAL
21	acetylcholine32 9 18 9	10.8	BMP6, BDNF, UCN, CD40LG, CD160, IL13
22	polymyxin b32	7.8	SERPINE1, VCAM1, LBP, CD14, IL10, IL1A
23	imiquimod32 42 9 9	10.6	BMP6, IL10, IL18, IL1A, IL5, IL6
24	poly(i-c)32	7.6	VCAM1, CD69, IL18, IL3, IL4, IL5
25	okt332	7.6	VCAM1, BMP6, CD40LG, IL10, IL18R1, IL2
26	norepinephrine32 9 18 9	10.5	VCAM1, BMP6, BDNF, UCN, CD14, CD40LG
27	ly29400232	7.5	CD69, GZMB, IL10, IL13, IL17A, IL18
28	matrigel32	7.4	SERPINE1, VCAM1, BMP6, BDNF, IL18, IL8
29	15-deoxy-delta-12,14-prostaglandin j232	7.2	SERPINE1, VCAM1, BMP6, IL10, IL4, IL6
30	hydrocortisone32 9 9	8.8	BMP6, CD14, MIF, IL10, IL13, IL1A
31	polysaccharide32	6.5	VCAM1, BMP6, LBP, CD209, CD69, CD14
32	creatinine32	6.2	BMP6, BDNF, SCGB1A1, LBP, CD69, CD14
33	cyclosporin a32 42	7.0	XCL1, CD28, CD69, CD86, CD14, CD80
34	tacrolimus32 34 9 9	9.0	SERPINE1, BMP6, XCL1, CD28, CD69, CD86
35	phosphatidylinositol32	5.9	PDE3B, VCAM1, BMP6, BDNF, BCL2, SCGB1A1
36	vegf32	5.8	SERPINE1, VCAM1, BDNF, BCL2, CD14, CD40LG
37	il 1032	5.4	BMP6, LBP, IL10, IL13, IL18, IL1A
38	lactate32	5.4	VCAM1, BMP6, BDNF, CD14, CD40LG, GZMB
39	alanine32	4.9	VCAM1, BMP6, SCGB1A1, LBP, CD14, CD4
40	indomethacin32 9 9	6.7	BMP6, BDNF, CD40LG, IL13, IL17A, IL18
41	tyrosine32	4.1	PDE3B, VCAM1, BMP6, BDNF, CISH, LBP
42	histamine32 18	5.0	PDE3B, VCAM1, BMP6, BDNF, UCN, CD86
43	actinomycin d32	3.7	SERPINE1, BDNF, BCL2, LBP, CD69, CD40LG
44	rantes32	3.7	VCAM1, BMP6, XCL1, CD209, CD14, CD4
45	mannose32	INF	CD209, CD69, CD86, CD14, CD4, CD80
46	dexamethasone32 42 34 9 9	INF	SERPINE1, VCAM1, BMP6, BCL2, CISH, UCN
47	cycloheximide32	INF	SERPINE1, BMP6, BDNF, BCL2, LBP, CD69
48	serine32	INF	PDE3B, SERPINB3, SERPINB4, SERPINE1, VCAM1, BMP6
49	pge232	INF	PDE3B, VCAM1, CD69, CD86, CD14, CD4
50	aspirin32 34 18	INF	SERPINE1, BMP6, CD40LG, ITGAL, IL13, IL18

Cellular components related to allergic asthma according to GeneDecks:

id	Name	GO ID	Score	Top Affiliating Genes
1	membrane raft	GO:045121	9.2	TLR4, TNF, CARD11, CD4, CD14, MS4A2
2	integral to plasma membrane	GO:005887	8.1	AGTR1, NGFR, NTRK1, CTLA4, TLR2, TLR4
3	external side of plasma membrane	GO:009897	7.6	IL2RB, IL4, ANXA5, CCR4, IFNG, ICOS
4	cell surface	GO:009986	7.5	NGFR, TLR2, TGFB1, DPP4, CX3CL1, PLAU
5	plasma membrane	GO:005886	5.6	ABP1, NGFR, NOS3, PLAU, NTRK1, CTLA4
6	extracellular space	GO:005615	4.4	SERPINE1, IL2, IL22, IL25, IL3, IL33
7	extracellular region	GO:005576	INF	FCAR, CCL5, IFNG, ICOS, SPINT2, PPBP

Biological processes related to allergic asthma according to GeneDecks:

(show top 50)    (show all 105)

id	Name	GO ID	Score	Top Affiliating Genes
1	cellular defense response	GO:006968	10.7	LBP, CXCL9, CD160, ITK, IL4, CCR9
2	positive regulation of natural killer cell chemotaxis	GO:2000503	10.5	CCL4, XCL1, CCL3, CCL5
3	leukocyte chemotaxis	GO:030595	10.5	CX3CL1, PF4, IL16, IL10
4	negative regulation of interferon-gamma production	GO:032689	10.3	SCGB1A1, GATA3, HLA-DRB1, IL33, FOXP3, XCL1
5	chemotaxis	GO:006935	10.2	PPBP, PLAU, RNASE2, CX3CR1, CXCL10, CXCL9
6	positive regulation of calcium-mediated signaling	GO:050850	10.2	CD4, ITGAL, FCER1A, CCL4, CCL3, SYK
7	neutrophil chemotaxis	GO:030593	10.0	CX3CL1, SYK, EDN1, IFNG, CCL3, IL8
8	cellular response to lipoteichoic acid	GO:071223	10.0	TLR2, CD14, TLR4, LBP
9	positive regulation of interleukin-10 production	GO:032733	10.0	XCL1, CD40LG, TLR4, IL4, HSPD1
10	leukocyte cell-cell adhesion	GO:007159	10.0	CD40LG, SYK, CCL5, VCAM1, CD209, ITGAL
11	positive regulation of MHC class II biosynthetic process	GO:045348	10.0	IFNG, IL10, CD40LG, IL4, TLR4
12	positive regulation of interleukin-2 biosynthetic process	GO:045086	10.0	IL1A, CD80, CD4, CD28, CD86
13	positive regulation of tumor necrosis factor production	GO:032760	9.9	TLR4, IFNG, CCL3, IL18, CD14, LBP
14	cellular response to tumor necrosis factor	GO:071356	9.9	IL18, CCL3, IL8, CCL5, EDN1, GATA3
15	positive regulation of isotype switching to IgG isotypes	GO:048304	9.9	IL4, IFNG, TBX21, IL2
16	regulation of sensory perception of pain	GO:051930	9.9	IL10, ADRB2, TLR4, CCL3, IL1A, EDN1
17	response to virus	GO:009615	9.9	IFNG, CCL5, CCL11, CCL4, CCL22, FOXP3
18	positive regulation of angiogenesis	GO:045766	9.9	CCL5, CCL11, IL1A, NTRK1, SERPINE1, CX3CR1
19	cellular response to lipopolysaccharide	GO:071222	9.8	LBP, CD14, IL10, IL8, SERPINE1, CX3CR1
20	B cell differentiation	GO:030183	9.8	NTRK1, AICDA, CD40LG, VCAM1, IL10, IL4
21	positive regulation of interleukin-8 production	GO:032757	9.8	IL18, SERPINE1, TLR4, TLR2, LBP
22	response to lipopolysaccharide	GO:032496	9.7	SOCS1, LBP, IL13, EDN1, TLR4, CXCL10
23	negative regulation of growth of symbiont in host	GO:044130	9.6	IL10, IFNG, TNF, TLR2, LBP
24	cell surface receptor signaling pathway	GO:007166	9.6	CD4, MIF, IFNG, CD14, ADRB2, CXCL10
25	positive regulation of cytokine secretion	GO:050715	9.6	IL1A, IL10, SYK, MIF, TLR2, CD14
26	T cell receptor signaling pathway	GO:050852	9.5	CD4, ITK, CARD11, HLA-DPB1, HLA-DQB1, GATA3
27	cell-cell signaling	GO:007267	9.5	IL13, IL17A, IL18, IL2, IL22, IL3
28	positive regulation of T cell proliferation	GO:042102	9.5	CCL5, IL6, IL4, ITGAL, CD28, IFNG
29	signal transduction	GO:007165	9.4	IL13, FLT3LG, ITK, ITGAL, CD4, XCL1
30	positive regulation of peptidyl-tyrosine phosphorylation	GO:050731	9.4	MIF, CD4, FCER1A, IL3, IL5, TLR4
31	defense response to Gram-negative bacterium	GO:050829	9.4	TLR4, CD4, SERPINE1, IL6, LBP
32	positive regulation of B cell proliferation	GO:030890	9.4	IL5, BCL2, CD40LG, MIF, IL13, IL2
33	T cell costimulation	GO:031295	9.4	CD4, CARD11, DPP4, CTLA4, HLA-DRB1, ICOS
34	positive regulation of smooth muscle cell proliferation	GO:048661	9.3	CX3CL1, IL13, STAT1, EDN1, TNF, CCL5
35	positive regulation of chemokine production	GO:032722	9.3	IL6, TLR4, TLR2, LBP, TNF, IL18
36	response to glucocorticoid stimulus	GO:051384	9.2	IL10, SERPINE1, CCL5, NGF, TNF, HNMT
37	interferon-gamma-mediated signaling pathway	GO:060333	9.1	VCAM1, SOCS1, STAT1, HLA-DRB1, HLA-DQB1, HLA-DPB1
38	positive regulation of immunoglobulin secretion	GO:051024	9.0	IL6, IL5, IL33, IL2
39	positive regulation of interferon-gamma production	GO:032729	9.0	HSPD1, CD40LG, IL18, IL2, TNF, TLR4
40	positive regulation of interleukin-6 production	GO:032755	9.0	TLR2, TLR4, IL6, HSPD1, LBP, UCN
41	humoral immune response	GO:006959	8.9	CD28, TNF, IFNG, GATA3, MS4A2, IL6
42	lipopolysaccharide-mediated signaling pathway	GO:031663	8.6	TGFB1, CCL3, LBP, IL18, CCL5, TNF
43	cytokine-mediated signaling pathway	GO:019221	8.5	IL2RB, IFNG, HLA-DQB1, IL6, IL5, IL1A
44	response to hypoxia	GO:001666	7.8	TLR4, EDN1, VCAM1, CX3CL1, DPP4, TGFB1
45	response to drug	GO:042493	7.8	BCL2, EDN1, ABP1, IL10, IL4, TGFB1
46	anti-apoptosis	GO:006916	7.7	ANXA5, IL2, F3, HSPA1B, NOS3, TPT1
47	immune response	GO:006955	7.2	IL1A, IL2, IL2RA, IL3, IL4, IL4R
48	inflammatory response	GO:006954	6.7	CCL18, CCL5, TNF, NGF, TLR2, TGFB1
49	positive regulation of transcription from RNA polymerase II promoter	GO:045944	6.7	TLR2, TLR4, TGFB1, STAT1, ADRB2, GATA3
50	positive regulation of inflammatory response	GO:050729	INF	TLR4, IL2, IL18, SERPINE1, CX3CL1, TLR2

Molecular functions related to allergic asthma according to GeneDecks:

(show all 13)

id	Name	GO ID	Score	Top Affiliating Genes
1	chemokine receptor activity	GO:004950	10.3	CXCR3, CX3CR1, CCR9, CCR4
2	lipoteichoic acid binding	GO:070891	10.3	LBP, CD14, TLR2
3	CCR5 chemokine receptor binding	GO:031730	10.3	CCL4, CCL3, CCL5
4	lipopolysaccharide binding	GO:001530	10.2	TLR4, HSPD1, CD14, LBP
5	cell surface binding	GO:043498	10.2	HSPD1, F3, MIF, LBP
6	chemokine activity	GO:008009	10.2	CXCL9, CCL22, CCL26, CCL4, IL8, XCL1
7	CCR1 chemokine receptor binding	GO:031726	10.1	CCL5, CCL3, CCL4
8	coreceptor activity	GO:015026	9.6	CD28, CD86, CD4, CD80
9	protease binding	GO:002020	9.1	DPP4, TNF, HSPA1B, F3, CD28, BCL2
10	protein homodimerization activity	GO:042803	8.3	ABP1, TIMELESS, TGFB1, DPP4, STAT1, NR6A1
11	growth factor activity	GO:008083	7.5	IL6, PPBP, NGF, TGFB1, CSF2, IL5
12	cytokine activity	GO:005125	7.0	CSF2, CXCL9, EDN1, TNF, IFNG, CCL4
13	protein binding	GO:005515	4.7	NOS3, NGFR, AGTR1, AHR, TLR2, PLAU